Affinage

SLIT1

Slit homolog 1 protein · UniProt O75093

Length
1534 aa
Mass
167.9 kDa
Annotated
2026-06-10
37 papers in source corpus 22 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLIT1 is a secreted axon guidance cue that, cooperating with SLIT2, provides repulsive activity to steer developing axons and define key landmarks of the nervous system, including the corridor that positions the optic chiasm and the chemorepellent septal signal that organizes the lateral olfactory tract (PMID:11804570, PMID:12097499). Its guidance functions are mediated principally through Robo2: Slit1-Robo2 signaling enforces dorsoventral zonal segregation of olfactory sensory neuron axons (PMID:17715346), and at subthreshold concentrations Slit1 instead potentiates Netrin-1 chemotactic responses, switching axonal behavior in a context-dependent manner (PMID:25888985). Beyond repulsion, Slit1 acts as a growth-promoting and morphogenic factor, stimulating cortical dendrite branching and axon elongation via endogenous Robo1/Robo2 and the SH2/SH3 adaptor Nck2, and promoting neurite outgrowth in DRG neurons through Robo2 (PMID:21600986, PMID:20172023). SLIT1-Robo2 signaling extends to non-neuronal morphogenesis: it drives directional pioneer myoblast migration through RhoA-dependent cytoskeletal remodeling (PMID:21653616), and controls neural crest-placode interactions during trigeminal gangliogenesis by post-translationally regulating N-cadherin surface levels (PMID:18278043, PMID:19934013). In the adult and pathological CNS, neuron-derived secreted Slit1 directs oligodendrocyte precursor differentiation and myelination through a Robo2-srGAP1-RhoA axis and restrains neural precursor migration to demyelinating lesions (PMID:32670024, PMID:40117292). SLIT1 also functions outside the nervous system as an autocrine/paracrine antagonist of gonadotropin-induced PI3K/AKT/FOXO1 signaling in ovarian granulosa cells, where it promotes apoptosis and limits follicle survival (PMID:38943353, PMID:40996529). SLIT1 expression is itself tightly controlled, induced transcriptionally by FGFR1 signaling (PMID:29705951), modulated by the homeobox factor Irx4 (PMID:12571096), and epigenetically repressed by SUV39H2-catalyzed H3K9 trimethylation of its promoter (PMID:29458143).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2002 High

    Established that SLIT1 is a functionally redundant axon repellent acting with SLIT2 to pattern major CNS axon tracts, explaining why single mutants are near-normal.

    Evidence Reciprocal genetic epistasis with Slit1/Slit2 single and double knockout mice plus anterograde tracing of retinal and olfactory axons

    PMID:11804570 PMID:12097499

    Open questions at the time
    • Does not identify the receptor mediating these repulsive effects
    • Cannot separate cell-autonomous from tissue-level contributions of Slit1 alone
  2. 2003 Medium

    Defined upstream transcriptional control of Slit1 by the homeobox factor Irx4 and revealed a context where Slit1 acts as a positive intraretinal guidance cue rather than a simple repellent.

    Evidence In ovo Irx4 overexpression and dominant-negative assays with in situ hybridization in chick retina

    PMID:12571096

    Open questions at the time
    • Direct versus indirect transcriptional regulation not resolved
    • Receptor mediating the positive guidance effect not identified
  3. 2003 High

    Delimited the scope of SLIT1 function by showing it is dispensable for tangential interneuron migration but required for midline-proximal neuronal positioning.

    Evidence In vitro migration assays and in vivo positioning analysis in Slit1/Slit2 double knockout mice

    PMID:12642493

    Open questions at the time
    • Mechanism of cholinergic neuron mispositioning not defined
    • Receptor and downstream effectors not addressed
  4. 2007 High

    Identified Robo2 as the receptor through which Slit1 directs olfactory axon zonal segregation, linking ligand-receptor expression gradients to topographic targeting.

    Evidence robo-2 and slit-1 single knockout mice with axon targeting and gradient expression analysis

    PMID:17715346

    Open questions at the time
    • Downstream signaling effectors in OSNs not defined
    • Quantitative ligand-receptor gradient relationship not modeled
  5. 2008 High

    Extended SLIT1-Robo2 signaling beyond axon guidance to cell-cell recognition, showing it mediates neural crest-placode interactions essential for trigeminal ganglion assembly.

    Evidence Reciprocal RNAi knockdown of Slit1 and Robo2, Robo2 function-blocking, and neural crest ablation in chick embryos

    PMID:18278043

    Open questions at the time
    • Intracellular effectors of the adhesive response not defined at this stage
    • Whether SLIT2 contributes redundantly not tested
  6. 2009 Medium

    Revealed the molecular output of Slit1-Robo2 in gangliogenesis as post-translational control of N-cadherin surface levels, defining a cell-adhesion mechanism distinct from transcriptional regulation.

    Evidence In vivo RNAi, dominant-negative Robo, N-cadherin rescue and surface quantification in chick embryos

    PMID:19934013

    Open questions at the time
    • Biochemical link between Robo2 and N-cadherin trafficking not resolved
    • Single-lab evidence without reciprocal biochemical validation
  7. 2010 Medium

    Demonstrated that recombinant SLIT1 can act as a direct growth-promoting cue via Robo2, contrasting with its classical repellent role.

    Evidence Recombinant Slit1 and Robo2/Fc decoy treatment of adult DRG neuron cultures with neurite measurements

    PMID:20172023

    Open questions at the time
    • Intracellular signaling not characterized
    • In vivo relevance not established
  8. 2011 Medium

    Identified RhoA-dependent cytoskeletal remodeling and the adaptor Nck2 as downstream effectors of Slit1-Robo signaling controlling cell migration and neuronal morphology.

    Evidence Somite inversion and loss-of-function in chick myoblasts with RhoA analysis; Robo1/Robo2 knockout neurons with Nck1/Nck2 binding and requirement assays

    PMID:21600986 PMID:21653616

    Open questions at the time
    • How Robo selects Nck2 over Nck1 not fully resolved
    • Direct connection between Nck2 and RhoA activation not established
  9. 2015 Medium

    Showed that SLIT1 dose tunes axon responsiveness, with subthreshold levels potentiating Netrin-1 responses, establishing concentration-dependent crosstalk between guidance systems.

    Evidence Microfluidic gradient turning assays of thalamic and hippocampal neurons with varying Slit1 and Netrin-1 concentrations

    PMID:25888985

    Open questions at the time
    • Receptor-level basis for the Slit1-Netrin1 interaction not defined
    • In vivo significance of subthreshold potentiation not demonstrated
  10. 2018 Medium

    Defined two layers of SLIT1 expression control — FGFR1-driven transcription and SUV39H2-mediated epigenetic repression — explaining how SLIT1 levels are set in development and disease.

    Evidence Slit1 promoter reporter and Fgfr subtype modulation in Xenopus; ChIP and H3K9me3 analysis with SUV39H2 knockdown/overexpression rescue in colorectal cancer cells

    PMID:29458143 PMID:29705951

    Open questions at the time
    • FGFR1-to-promoter transcription factor link not identified
    • Functional consequence of SLIT1 silencing in cancer not mechanistically tied to Robo signaling
  11. 2020 Medium

    Established a cell-autonomous role for Slit1 in restraining adult neural precursor migration during demyelination, expanding its function to adult CNS repair.

    Evidence Time-lapse imaging of purified Slit1-deficient NPCs and in vivo lesion recruitment in Slit1 knockout mice

    PMID:32670024

    Open questions at the time
    • Receptor and intracellular pathway in NPCs not defined
    • Single-lab evidence
  12. 2024 Medium

    Identified SLIT1 as an antagonist of gonadotropin-induced PI3K/AKT signaling in granulosa cells, defining a reproductive function outside the nervous system.

    Evidence Slit1-null mouse fertility and follicle analysis plus recombinant SLIT1 treatment of granulosa cells with phospho-AKT and apoptosis readouts

    PMID:38943353

    Open questions at the time
    • Receptor mediating granulosa cell effects not identified in this study
    • Direct versus indirect AKT inhibition not resolved
  13. 2025 Medium

    Resolved the oligodendroglial signaling axis (Robo2-srGAP1-RhoA) for neuron-derived Slit1 in myelination and showed Robo1 is not the sole granulosa receptor, refining receptor usage across tissues.

    Evidence Conditional neuronal Slit1 knockout with RhoA pharmacological rescue in hypoxia; RNA-seq and FOXO1/AKT assays in Robo1-null granulosa cells

    PMID:40117292 PMID:40996529

    Open questions at the time
    • Granulosa cell SLIT1 receptor remains unidentified
    • Whether srGAP1-RhoA operates in non-oligodendroglial contexts not tested
  14. 2026 Medium

    Defined a sex-specific role for Slit1 in adult forebrain neuroplasticity, linking it to dentate gyrus neurogenesis, synaptic protein levels, and the Srgap2 effector in females.

    Evidence Viral Slit1 knockdown in rat dentate gyrus and mouse vmPFC with electrophysiology, morphology, and transcriptomic readouts

    PMID:33896623 PMID:42105438

    Open questions at the time
    • Molecular basis of sex specificity not established
    • Receptor mediating adult plasticity effects not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • The receptor and effector logic that allows SLIT1 to switch between repulsion, growth promotion, adhesion control, and AKT antagonism across tissues remains unresolved.
  • No unifying structural or biochemical model of context-dependent SLIT1 output
  • Granulosa cell receptor unidentified
  • Mechanism by which the same ligand produces opposite cellular responses not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 4 GO:0098631 cell adhesion mediator activity 2
Localization
GO:0005576 extracellular region 3
Pathway
R-HSA-1266738 Developmental Biology 5 R-HSA-112316 Neuronal System 4 R-HSA-162582 Signal Transduction 4
Partners
NCK2ROBO1ROBO2SRGAP1

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 Slit1 and Slit2 cooperate to repel retinal ganglion cell axons in vivo, establishing a corridor that defines the site of optic chiasm formation. Double knockout mice (Slit1/Slit2) develop an ectopic anterior chiasm and axons project aberrantly, whereas single knockouts show few defects, demonstrating genetic redundancy and cooperative repulsion. Genetic epistasis using Slit1 and Slit2 single and double knockout mice with anterograde axon tracing Neuron High 11804570
2002 Slit1 and Slit2 together constitute the chemorepellent activity of the septum that guides olfactory bulb axons to form the lateral olfactory tract (LOT). Septum from Slit1/Slit2 double-deficient mice progressively loses repulsive activity in a gene-dose-dependent manner, and LOT is completely disorganized in double mutants with axons entering the septum. Co-culture of olfactory bulb explants with septum from Slit1/Slit2-deficient mice; anterograde tracing of LOT in single and double knockout mice The Journal of neuroscience High 12097499
2003 Slit1 and Slit2 are not required for tangential migration of cortical interneurons from the basal telencephalon to the cortex; the repulsive activity in the basal telencephalon is maintained in Slit1/Slit2 double-deficient mice. However, loss of Slit1 and Slit2 disrupts positioning of cholinergic neurons in the basal magnocellular complex, indicating a role in cell positioning close to the midline. In vitro migration assays with basal telencephalon tissue from Slit1/Slit2 double-knockout mice; in vivo analysis of neuronal positioning in single and double knockouts Development (Cambridge, England) High 12642493
2003 Irx4 transcriptionally regulates Slit1 expression in the chicken retina: Irx4 overexpression specifically downregulates Slit1 expression, while dominant-negative Irx4 induces Slit1 expression. Slit1 acts positively to guide retinal axons within the optic fiber layer. In ovo overexpression and dominant-negative assays in chick retina; in situ hybridization; in vivo axon behavior assays Development (Cambridge, England) Medium 12571096
2007 Slit-1 signaling through its receptor Robo-2 is required for dorsoventral zonal segregation of olfactory sensory neuron (OSN) axons in the olfactory bulb. In slit-1(-/-) mice, a subset of OSN axons that normally project to the dorsal OB mistarget to the ventral region. Robo-2 is expressed in OSNs in a high dorsomedial to low ventrolateral gradient, and Slit-1 is expressed in the ventral OB. Knockout mouse analysis (robo-2(-/-) and slit-1(-/-)); axon targeting assays; expression analysis by in situ hybridization The Journal of neuroscience High 17715346
2008 Slit1, expressed on cranial neural crest cells, signals through Robo2 on ectodermal placode cells to mediate neural crest-placode cell interactions required for proper trigeminal ganglion assembly. RNAi depletion of Slit1 or Robo2, or blocking Robo2 function, disrupts ganglion formation mimicking neural crest ablation. RNA interference knockdown of Slit1 and Robo2 in chick embryos; Robo2 function-blocking experiments; neural crest ablation; in situ hybridization for expression Nature neuroscience High 18278043
2009 Slit1-Robo2 signaling modulates N-cadherin protein expression on the placodal cell surface (post-translational regulation) to control placodal cell adhesion during trigeminal gangliogenesis. Blocking or augmenting Slit-Robo signaling alters N-cadherin surface levels without changing total N-cadherin mRNA or protein, and N-cadherin co-expression reverses Robo2 loss-of-function phenotypes. In vivo RNAi knockdown; dominant-negative Robo expression; N-cadherin overexpression rescue; surface N-cadherin quantification; mRNA analysis in chick embryos Development (Cambridge, England) Medium 19934013
2011 Sclerotome-derived Slit1 signals through Robo2 expressed on pioneer myoblasts downstream of MyoD and Myf5 to drive directional migration and differentiation of pioneer myoblasts, acting via RhoA to regulate cytoskeletal assembly. Loss of Robo2 or sclerotome Slit1 function perturbs directional migration and fiber formation without affecting myoblast specification. Somite inversion experiments in avian embryos; loss-of-function perturbation of Robo2 and Slit1 in chick; RhoA pathway analysis; expression analysis by in situ hybridization Development (Cambridge, England) Medium 21653616
2011 Slit1 stimulates cortical dendrite branching and axon elongation through endogenous Robo1/Robo2 receptors. The SH2/SH3 adaptor protein Nck2 (but not Nck1) is specifically required downstream of Robo activation for Slit1-induced changes in cortical neuron morphology; Nck1 and Nck2 both bind Robo via an atypical SH3-mediated mechanism. In vitro neurite growth assays with Slit1; Robo1/Robo2 double-knockout neurons; Nck1 and Nck2 binding assays; Nck2 requirement tested in cortical neuron cultures Molecular and cellular neurosciences Medium 21600986
2010 Recombinant Slit1 protein promotes neurite outgrowth and elongation in adult dorsal root ganglion neurons via binding to the Robo2 receptor. A soluble Robo2/Fc chimera that competes for Slit1 binding inhibits neurite outgrowth, indicating Slit1-Robo2 signaling mediates the growth-promoting effect. In vitro DRG neuron cultures treated with recombinant Slit1 protein or Robo2/Fc chimera; neurite length measurements Journal of chemical neuroanatomy Medium 20172023
2015 Subthreshold (subrepellent) concentrations of Slit1 potentiate Netrin-1 chemotactic responses in rostral thalamic axons and hippocampal neurons; at subthreshold levels Slit1 promotes Netrin-1 attraction or repulsion depending on substrate context, while at threshold levels Slit1 alone is repulsive. Microfluidic gradient device with dissociated neurons and explant cultures; quantitative axon turning assays with varying Slit1 and Netrin-1 concentrations Neural development Medium 25888985
2018 SUV39H2 directly binds to the SLIT1 promoter and suppresses SLIT1 transcription by catalyzing histone H3 lysine 9 (H3K9) tri-methylation, thereby repressing SLIT1 expression in colorectal cancer cells. ChIP assay showing SUV39H2 binding to SLIT1 promoter; H3K9me3 ChIP; SUV39H2 knockdown and overexpression with SLIT1 expression rescue assays in colorectal cancer cells Cancer letters Medium 29458143
2018 Fibroblast growth factor receptor 1 (Fgfr1) signaling is the main transcriptional regulator of slit1 expression. An Fgf-responsive 2.3 kb slit1 promoter sequence recapitulates endogenous spatiotemporal expression in the neural tube and eye of Xenopus embryos, and signaling specifically through Fgfr1 (but not other Fgfr subtypes) controls slit1 forebrain expression in a cell-autonomous manner. Reporter assay with 2.3 kb slit1 promoter in Xenopus embryos; in vitro promoter activity assays in A6 cells; selective Fgfr subtype modulation Cellular and molecular life sciences Medium 29705951
2020 Slit1 regulates adult SVZ-derived neural precursor (NPC) migration in demyelinating conditions in a cell-autonomous manner. Slit1-deficient NPCs migrate faster and make more frequent directional changes than control NPCs (shown by time-lapse video-microscopy), and more SVZ-NPCs are recruited to demyelinating lesions in Slit1(-/-) mice, resulting in higher Olig2+ cell numbers within the lesion. Time-lapse video-microscopy of immuno-purified Slit1-deficient NPCs; in vivo comparison of Slit1(-/-) vs Slit1(+/-) mice with corpus callosum demyelination; cell counting in lesions Frontiers in cellular neuroscience Medium 32670024
2021 Knockdown of Slit1 in the vmPFC of female (but not male) mice, combined with stress, decreases dendritic arborization and excitability of pyramidal neurons and augments the transcriptional stress signature, establishing a sex-specific cell-autonomous role for Slit1 in regulating neurophysiology and stress responses. Viral Slit1 knockdown in vmPFC of male and female mice; dendritic morphology analysis; electrophysiology; RNA sequencing of vmPFC Biological psychiatry Medium 33896623
2024 Exogenous SLIT1 induces apoptosis in granulosa cells and inhibits AKT phosphorylation stimulated by both FSH and LH, establishing SLIT1 as an autocrine/paracrine antagonist of gonadotropin-induced PI3K/AKT signaling in ovarian follicle development. Slit1-null female mice produce larger litters due to increased ovulation from greater healthy antral follicle numbers. Slit1-null mouse model (in vivo fertility assays, follicle counting, phospho-AKT western blot); exogenous recombinant SLIT1 treatment of cultured granulosa cells (apoptosis assay, cell proliferation assay, western blot for AKT signaling) Biology of reproduction Medium 38943353
2025 Secreted Slit1 from hypoxic neurons directly targets oligodendrocyte precursors through Robo2-srGAP1-RhoA signaling to promote oligodendrocyte differentiation and myelination. Conditional neuronal ablation of Slit1 exacerbates hypoxia-induced hypomyelination; pharmacological inhibition of RhoA restores myelination. Conditional neuron-specific Slit1 knockout mice under hypoxic conditions; pharmacological RhoA inhibition; signaling pathway analysis (Robo2-srGAP1-RhoA); behavioral readouts Cell reports Medium 40117292
2025 SLIT1 antagonizes FSH-induced FOXO1 phosphorylation (but not LH-induced FOXO1 phosphorylation) in granulosa cells, and loss of Robo1 does not inhibit SLIT1's ability to antagonize AKT/FOXO1 signaling, indicating Robo1 is not the sole receptor mediating SLIT1 signaling in granulosa cells. SLIT1 and SLIT2 share common transcriptional targets and mechanisms, while SLIT3 does not replicate these effects. RNA-seq of granulosa cells treated with SLIT1; western blot for FSH/LH-induced FOXO1/AKT phosphorylation; Robo1-null granulosa cells treated with SLIT1/SLIT2; apoptosis assays Reproduction (Cambridge, England) Medium 40996529
2004 A Slit1 alternative splice variant, Slit1alpha, arises through alternative splicing at the C-terminus causing a defect in the cysteine knot domain. Slit1alpha is expressed in hippocampus and cerebral cortex of rat brain and functions as a chemorepellent in olfactory bulb axon guidance in vitro. Molecular cloning; in situ hybridization; in vitro olfactory bulb axon repulsion assay Journal of biochemistry Low 15632296
2019 The ATP-P2X7 receptor signaling pathway in dorsal root ganglion satellite glial cells (SGCs) mediates upregulation of Slit1 expression following peripheral nerve injury. Injured neurons release ATP via increased vesicular nucleotide transporter (VNUT), and P2X7R inhibition (BBG) downregulates Slit1 in SGCs and upregulates VNUT in DRG neurons, indicating a neuron-to-SGC signal transduction mechanism. P2X7R pharmacological inhibition (BBG injection); VNUT expression analysis; double immunofluorescence; western blot; retrograde tracing in rat nerve injury model Frontiers in cellular neuroscience Low 31607866
2024 Exogenous recombinant Slit1 protein promotes fibroblast proliferation, differentiation, and migration, upregulates ECM components (α-SMA, collagen I and III, fibronectin), and activates both SMAD (SMAD2/3, SMAD1/5/8) and non-SMAD (TAK1, JNK1, ERK1/2, p38) TGF-β pathway proteins in human normal fibroblasts. Recombinant Slit1 treatment of cultured human fibroblasts; western blot for signaling pathway activation; cell proliferation, migration, and differentiation assays Medicina (Kaunas, Lithuania) Low 39768930
2025 Slit1 is identified as a downstream transcriptional target of MET signaling in embryonic limb myogenic progenitors. Conditional Met knockout in the Pax3/somitic lineage reduces Slit1 expression in limb buds, and pharmacological MET inhibition in vitro confirms Slit1 as a MET-responsive gene. Slit1 knockdown in myoblasts leads to precocious myogenic differentiation, suggesting Slit1 represses premature myogenic commitment downstream of MET. Conditional Met knockout mice (cMet KO); pharmacological MET inhibition (SU11274) in vitro; Slit1 knockdown in myoblasts; gene expression analysis bioRxivpreprint Low
2026 Viral knockdown of Slit1 in the hippocampal dentate gyrus of female (but not male) rats reduces neural stem cell and immature neuron markers (Sox2, DCX), decreases postsynaptic proteins (Homer1, PSD95, GluA1) without affecting Synaptophysin, diminishes sEPSC amplitude, and downregulates the downstream effector Srgap2 specifically in females, linking Slit1 to female-specific DG neuroplasticity. Viral Slit1 knockdown in rat dentate gyrus; immunofluorescence for neural markers; western blot; whole-cell patch-clamp electrophysiology; gene expression analysis Neurotherapeutics Medium 42105438

Source papers

Stage 0 corpus · 37 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Neuron 351 11804570
2004 Epigenetic inactivation of SLIT3 and SLIT1 genes in human cancers. British journal of cancer 122 15534609
2003 Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction. Development (Cambridge, England) 119 12642493
2007 Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience 95 17715346
2009 N-cadherin acts in concert with Slit1-Robo2 signaling in regulating aggregation of placode-derived cranial sensory neurons. Development (Cambridge, England) 73 19934013
2005 Expression of netrin-1, slit-1 and slit-3 but not of slit-2 after cerebellar and spinal cord lesions. The European journal of neuroscience 73 16262652
2008 Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion. Nature neuroscience 72 18278043
2002 Slit1 and slit2 proteins control the development of the lateral olfactory tract. The Journal of neuroscience : the official journal of the Society for Neuroscience 58 12097499
2003 Irx4-mediated regulation of Slit1 expression contributes to the definition of early axonal paths inside the retina. Development (Cambridge, England) 49 12571096
2018 SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter. Cancer letters 46 29458143
2003 Two divergent slit1 genes in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists 43 14579375
2020 Dynamic expression of Slit1-3 and Robo1-2 in the mouse peripheral nervous system after injury. Neural regeneration research 27 31719262
2006 Dynamic changes in Robo2 and Slit1 expression in adult rat dorsal root ganglion and sciatic nerve after peripheral and central axonal injury. Neuroscience research 27 16979769
2001 Slit1 is specifically expressed in the primary and secondary enamel knots during molar tooth cusp formation. Mechanisms of development 27 11520671
2005 Comparative genomics on SLIT1, SLIT2, and SLIT3 orthologs. Oncology reports 26 16211308
2021 Sex-Specific Role for SLIT1 in Regulating Stress Susceptibility. Biological psychiatry 25 33896623
2016 Specific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes. International journal of oncology 24 27082735
2011 Sclerotome-derived Slit1 drives directional migration and differentiation of Robo2-expressing pioneer myoblasts. Development (Cambridge, England) 19 21653616
2015 Subrepellent doses of Slit1 promote Netrin-1 chemotactic responses in subsets of axons. Neural development 18 25888985
2011 The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology. Molecular and cellular neurosciences 15 21600986
2010 Slit1 promotes regenerative neurite outgrowth of adult dorsal root ganglion neurons in vitro via binding to the Robo receptor. Journal of chemical neuroanatomy 15 20172023
2010 Prefrontal-enriched SLIT1 expression in Old World monkey cortex established during the postnatal development. Cerebral cortex (New York, N.Y. : 1991) 10 20123755
2014 A subset of chicken statoacoustic ganglion neurites are repelled by Slit1 and Slit2. Hearing research 9 24456709
2004 Expression and function of Slit1alpha, a novel alternative splicing product for slit1. Journal of biochemistry 9 15632296
2020 Slit1 Protein Regulates SVZ-Derived Precursor Mobilization in the Adult Demyelinated CNS. Frontiers in cellular neuroscience 8 32670024
2018 Fibroblast growth factor receptor 1 signaling transcriptionally regulates the axon guidance cue slit1. Cellular and molecular life sciences : CMLS 8 29705951
2020 Lhx2/9 and Etv1 Transcription Factors have Complementary roles in Regulating the Expression of Guidance Genes slit1 and sema3a. Neuroscience 7 32200077
2019 The ATP-P2X7 Signaling Pathway Participates in the Regulation of Slit1 Expression in Satellite Glial Cells. Frontiers in cellular neuroscience 7 31607866
2022 Micro RNA-640 Targeting SLIT1 Enhances Glioma Radiosensitivity by Restraining the Activation of Wnt/β-Catenin Signaling Pathway. British journal of biomedical science 6 35996510
2025 A neuronal Slit1-dependent program rescues oligodendrocyte differentiation and myelination under chronic hypoxic conditions. Cell reports 5 40117292
2013 Steerable-filter based quantification of axonal populations at the developing optic chiasm reveal significant defects in Slit2(-/-) as well as Slit1(-/-)Slit2(-/-) embryos. BMC neuroscience 4 23320558
2024 Slit1 inhibits ovarian follicle development and female fertility in mice†. Biology of reproduction 2 38943353
2024 Slit1 Promotes Hypertrophic Scar Formation Through the TGF-β Signaling Pathway. Medicina (Kaunas, Lithuania) 2 39768930
2014 Changes in expression of Slit1 and its receptor Robo2 in trigeminal ganglion and inferior alveolar nerve following inferior alveolar nerve axotomy in adult rats: a pilot study. International journal of oral and maxillofacial surgery 2 25457824
2025 Redundant functions and mechanisms of action of Slit1 and Slit2 in ovarian granulosa cells. Reproduction (Cambridge, England) 1 40996529
2026 A female-specific role for Slit1 in prenatal stress-induced depression vulnerability. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 0 42105438
2026 Identification and validation of serum SLIT1 as a biomarker for predicting anti-PD-1/PD-L1 resistance in non-small cell lung cancer. Biological procedures online 0 42135620

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