Affinage

SLIT1

Slit homolog 1 protein · UniProt O75093

Round 2 corrected
Length
1534 aa
Mass
167.9 kDa
Annotated
2026-04-28
130 papers in source corpus 33 papers cited in narrative 33 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLIT1 is a secreted glycoprotein containing leucine-rich repeat and EGF-like domains that functions as a repulsive axon guidance cue through Robo receptors, with roles extending beyond neural wiring to cell migration, myelination, ovarian physiology, and stress-related neuroplasticity. During development, SLIT1 cooperates with SLIT2 to channel retinal ganglion cell axons at the optic chiasm, organize the lateral olfactory tract, and repel dorsally projecting cranial motor axons, while independently directing olfactory sensory neuron zonal targeting via Robo2 and mediating neural crest–placode interactions during trigeminal gangliogenesis through post-translational modulation of N-cadherin surface levels (PMID:11804570, PMID:12097499, PMID:17715346, PMID:18278043, PMID:19934013). Beyond axon guidance, SLIT1 promotes oligodendrocyte differentiation under hypoxia through a Robo2–srGAP1–RhoA signaling axis, inhibits ovarian follicle development by antagonizing gonadotropin-stimulated AKT/FOXO1 signaling in granulosa cells, and modulates stress-induced dendritic remodeling and neuronal excitability in the female ventromedial prefrontal cortex (PMID:40117292, PMID:38943353, PMID:33896623). SLIT1 transcription is positively regulated by Fgfr1 signaling through Etv1 and negatively regulated by Irx4, Lhx2, and SUV39H2-mediated H3K9 trimethylation, and its promoter is subject to CpG hypermethylation-driven silencing in tumors (PMID:29705951, PMID:29458143, PMID:12571096).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1998 Medium

    Cloning of mammalian SLIT1 established it as a brain-specific secreted protein with conserved LRR and EGF-like domains, providing the molecular foundation for investigating vertebrate axon guidance.

    Evidence cDNA cloning, Northern blot, and in situ hybridization in rat and human tissues

    PMID:10349621 PMID:9813312

    Open questions at the time
    • No functional assay performed
    • Receptor identity unknown
    • No loss-of-function data
  2. 2002 High

    Double-knockout studies revealed that SLIT1 and SLIT2 cooperatively establish repulsive corridors for retinal axons at the optic chiasm and for olfactory bulb axons in the lateral olfactory tract, demonstrating genetic redundancy and defining the first in vivo guidance functions.

    Evidence Slit1−/−, Slit2−/−, and double-mutant mice with anterograde axon tracing and explant co-culture repulsion assays

    PMID:11804570 PMID:12097499

    Open questions at the time
    • Relative contribution of each Slit ligand to individual guidance decisions unclear
    • Downstream signaling mediators not identified
    • Whether Robo1 vs Robo2 mediates these specific responses not resolved
  3. 2005 High

    SLIT1 was shown to selectively repel dorsally projecting cranial motor axons but not ventrally projecting ones, establishing subtype specificity of Slit-Robo guidance in the hindbrain.

    Evidence Slit/Robo-deficient mouse analysis, ectopic Slit1 expression in chick, dominant-negative Robo expression in motoneurons

    PMID:16162649

    Open questions at the time
    • Molecular basis for selectivity between dorsal and ventral motor neuron subtypes unresolved
    • Identity of Robo subtype(s) mediating this selectivity not determined
  4. 2007 High

    Slit1 knockout mice revealed a specific role for SLIT1 in dorsoventral zonal targeting of olfactory sensory neuron axons, distinguishing its function from the redundant Slit1/Slit2 roles seen in other systems.

    Evidence Slit-1−/− and Robo-2−/− mice with axon tracing and expression gradient analysis in the olfactory bulb

    PMID:17715346

    Open questions at the time
    • Contribution of Slit3 to ventral repulsion not genetically dissected
    • How Robo2 gradient is established in OSNs unknown
  5. 2008 High

    Discovery that neural crest-derived SLIT1 signals through placodal Robo2 to assemble the trigeminal ganglion established a non-canonical role for Slit-Robo in cell–cell adhesive interactions during gangliogenesis.

    Evidence RNAi knockdown of Slit1/Robo2, function-blocking antibodies, neural crest ablation in chick embryos

    PMID:18278043

    Open questions at the time
    • Intracellular signaling cascade in placodal cells not fully elucidated
  6. 2009 High

    Epistasis experiments showed SLIT1-Robo2 signaling modulates N-cadherin surface levels post-translationally in placode cells, providing the first mechanistic link between Slit-Robo and adhesion molecule trafficking.

    Evidence RNAi, dominant-negative Robo, N-cadherin co-expression rescue, in ovo perturbation with epistasis analysis

    PMID:19934013

    Open questions at the time
    • Trafficking mechanism (endocytosis vs exocytosis of N-cadherin) not defined
    • Whether this mechanism operates in other Slit-Robo contexts unknown
  7. 2011 High

    Identification of the adaptor Nck2 as a Robo-binding partner specifically required for Slit1-induced cortical neurite morphology changes linked the receptor to cytoskeletal remodeling, and parallel work showed Slit1-Robo2-RhoA drives pioneer myoblast migration.

    Evidence Co-immunoprecipitation of Nck2-Robo, Nck2 RNAi in Robo1/2 KO cortical neurons; in ovo somite manipulations with RhoA pathway analysis for myoblast migration

    PMID:21600986 PMID:21653616

    Open questions at the time
    • Whether Nck2 and RhoA operate in the same or parallel downstream branches unresolved
    • Structural basis of Nck2-Robo interaction not determined
  8. 2015 High

    Subthreshold concentrations of Slit1 were found to potentiate Netrin-1 chemotactic responses rather than simply repelling axons, revealing an unexpected combinatorial guidance code.

    Evidence Microfluidic gradient device with quantitative axon turning assays on rostral thalamic and hippocampal neurons

    PMID:25888985

    Open questions at the time
    • Molecular mechanism of Slit-Netrin crosstalk at the receptor level not identified
    • Whether this combinatorial activity operates in vivo not tested
  9. 2018 Medium

    SLIT1 transcription was shown to be under dual epigenetic and signaling control: Fgfr1-Etv1 activates the slit1 promoter in the forebrain, while SUV39H2-mediated H3K9me3 silences SLIT1 in colorectal cancer, identifying upstream regulatory nodes.

    Evidence Promoter-reporter assays in Xenopus and cell lines for Fgfr1/Etv1; ChIP for SUV39H2 binding and H3K9me3 at SLIT1 promoter with siRNA rescue in cancer cells

    PMID:29458143 PMID:29705951

    Open questions at the time
    • Whether Fgfr1-Etv1 regulation is conserved in mammals not confirmed
    • Identity of chromatin readers downstream of H3K9me3 at SLIT1 locus unknown
    • Fgfr1 study in Xenopus only
  10. 2021 High

    Targeted Slit1 knockdown in female mouse vmPFC combined with stress produced depression-related behaviors, reduced dendritic arborization, and decreased neuronal excitability, establishing SLIT1 as a sex-specific modulator of stress vulnerability in the adult brain.

    Evidence Viral-mediated vmPFC Slit1 knockdown, chronic variable stress, behavioral testing, electrophysiology, dendritic morphology, RNA-seq

    PMID:33896623

    Open questions at the time
    • Downstream receptor and signaling pathway in vmPFC neurons not identified
    • Whether SLIT1 acts cell-autonomously or through paracrine signaling in vmPFC not resolved
    • Basis of sex specificity unknown
  11. 2024 High

    SLIT1 was identified as an inhibitor of ovarian follicle development that antagonizes gonadotropin-stimulated AKT phosphorylation in granulosa cells, extending SLIT1 function to reproductive physiology.

    Evidence Slit1 knockout mice with increased ovulation and fertility, recombinant SLIT1 treatment of granulosa cells with AKT phosphorylation and apoptosis assays

    PMID:38943353

    Open questions at the time
    • Identity of the SLIT1 receptor on granulosa cells not established (ROBO1 knockout did not abolish signaling)
    • Mechanism of AKT antagonism not defined
  12. 2025 High

    Neuron-derived SLIT1 was shown to promote oligodendrocyte differentiation under hypoxia via a Robo2–srGAP1–RhoA pathway, with pharmacological RhoA inhibition rescuing myelination deficits, and a human population genetics link to high-altitude adaptation was identified.

    Evidence Conditional neuron-specific Slit1 knockout in chronic hypoxia model, RhoA inhibitor rescue, behavioral testing, Tibetan population variant analysis

    PMID:40117292

    Open questions at the time
    • How hypoxia regulates neuronal SLIT1 secretion not defined
    • Whether srGAP1 is the sole RhoGAP mediating this response not tested
  13. 2025 High

    RNA-seq and receptor-knockout analysis in granulosa cells demonstrated that SLIT1 and SLIT2 share redundant antagonism of FSH-AKT/FOXO1 signaling and that ROBO1 is not the sole mediating receptor, narrowing the receptor identity question.

    Evidence RNA-seq of SLIT1-treated granulosa cells, recombinant SLIT1/2/3 comparative treatment, Robo1 knockout granulosa cells, AKT/FOXO1 phosphorylation assays

    PMID:40996529

    Open questions at the time
    • Identity of the non-ROBO1 receptor for SLIT1 in granulosa cells remains unknown
    • In vivo genetic validation of SLIT2 redundancy in fertility not yet performed

Open questions

Synthesis pass · forward-looking unresolved questions
  • The identity of the SLIT1 receptor in non-neuronal tissues (granulosa cells, fibroblasts), the structural basis of concentration-dependent switching between repulsion and Netrin-1 potentiation, and the mechanism underlying sex-specific SLIT1 effects in the adult prefrontal cortex remain unresolved.
  • No structural model of SLIT1-Robo2 complex available
  • Concentration-dependent signaling switch mechanism not defined at molecular level
  • Sex-specific chromatin or hormonal regulation of SLIT1 in brain not characterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 9 GO:0098772 molecular function regulator activity 3
Localization
GO:0005576 extracellular region 8
Pathway
R-HSA-112316 Neuronal System 9 R-HSA-1266738 Developmental Biology 8 R-HSA-162582 Signal Transduction 5 R-HSA-1474165 Reproduction 2 R-HSA-5357801 Programmed Cell Death 2
Partners
NCK2ROBO1ROBO2SLIT2SRGAP1

Evidence

Reading pass · 33 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 Mammalian SLIT1 (and SLIT2, SLIT3) were cloned as vertebrate homologs of Drosophila slit, encoding secreted proteins with leucine-rich repeat (LRR) and EGF-like domains. Northern blot analysis showed SLIT1 mRNA is exclusively expressed in the brain, and in situ hybridization confirmed rat Slit1 is specifically expressed in neurons of fetal and adult forebrains, suggesting a conserved role in nervous system formation. cDNA cloning, Northern blot, in situ hybridization Brain research. Molecular brain research Medium 9813312
1998 SLIT1 and SLIT2 were identified as large secreted proteins with multiple EGF-like motifs and LRR domains. Both genes are expressed during CNS development in the floor plate, roof plate, and developing motor neurons, paralleling Drosophila slit midline glial expression and implying conserved function in vertebrate midline axon guidance. cDNA cloning, in situ hybridization, protein domain analysis Mechanisms of development Medium 10349621
2002 Slit1 and Slit2 cooperate in vivo to repel retinal ganglion cell (RGC) axons and define the site of optic chiasm formation. Mice deficient in both Slit1 and Slit2 (but not single mutants) develop an ectopic anterior chiasm, with retinal axons projecting into the contralateral optic nerve and extending dorsally and laterally, demonstrating that Slit proteins establish a repulsive corridor channeling axons to the correct chiasm position. Genetic knockout (Slit1-/-, Slit2-/-, double mutant mice), anterograde axon tracing Neuron High 11804570
2002 Slit1 and Slit2 together act as the septal chemorepellent controlling lateral olfactory tract (LOT) development. Explant co-culture with septum from Slit1/Slit2 double-deficient mice progressively abolished septal repulsive activity for olfactory bulb axons in a gene dose-dependent manner. In vivo anterograde tracing showed LOT is completely disorganized only in double-deficient embryos, with axons reaching the midline and entering the septum. Genetic knockout, in vitro explant co-culture repulsion assay, anterograde axon tracing in vivo The Journal of neuroscience High 12097499
2002 Slit1 and Slit2 are expressed in the rat CNS with highly dynamic, largely complementary patterns relative to their Robo receptors from embryonic to adult stages. Postnatally, slit and robo expression is up-regulated in most brain regions, suggesting roles beyond axon pathfinding and in adult brain function. In situ hybridization (spatiotemporal expression mapping) The Journal of comparative neurology Low 11754167
2002 Genomic structure analysis showed SLIT1 is encoded by 37 exons covering at least 183 kb of human genomic DNA. EST database analysis revealed no additional Slit family members in mouse or human. Alternative splicing potential was identified through modular exon-intron organization, and mammalian SLIT1 promoters contain conserved double TCF/LEF and bHLH-binding sites, identifying SLIT1 as an evolutionarily conserved target of the WNT/β-catenin signaling pathway. Long-distance PCR, in silico genomic mapping, EST database analysis, comparative genomics The International journal of developmental biology Low 12141424
2003 Slit1 and Slit2 are not required for tangential migration of cortical interneurons from the basal telencephalon to the cortex, but are required for proper positioning of cholinergic neurons of the basal magnocellular complex. In vitro experiments with Slit1/Slit2 double-deficient mice showed the basal telencephalon repulsive activity for tangentially migrating cells is maintained, indicating other factors account for this repulsion, while Slit1/Slit2 regulate cell positioning near the midline. Genetic knockout (Slit1-/-, Slit2-/-, triple Slit1/Slit2/netrin1 mutants), in vitro repulsion assay, in vivo cell migration analysis Development (Cambridge, England) High 12642493
2003 The homeobox transcription factor Irx4 is a crucial regulator of Slit1 expression in the chicken retina. Overexpression of Irx4 specifically downregulated Slit1 expression, while inhibition of Irx4 by a dominant-negative mutant induced Slit1 expression. Functional assays showed that Slit1 acts positively to guide retinal axons inside the optic fiber layer, providing intermediate targets during their growth within the retina. Gain-of-function overexpression, dominant-negative inhibition, in vivo retinal axon guidance assays Development (Cambridge, England) Medium 12571096
2003 Two divergent zebrafish slit1 orthologs, slit1a and slit1b, were cloned. Both predicted proteins contain conserved LRR and EGF motifs. slit1a is broadly expressed in the CNS, somites, and fin buds; slit1b is restricted to the olfactory system and retina. Both are expressed at the midline, suggesting conserved axon guidance roles, while divergent expression patterns imply distinct functions. cDNA cloning, in situ hybridization (zebrafish embryos) Developmental dynamics Low 14579375
2004 A novel alternative splice product of Slit1, designated Slit1alpha, was identified with highest expression in rat hippocampus and cerebral cortex. Slit1alpha arises through alternative splicing at the C-terminus causing a defect in the cysteine knot domain. In vitro assays demonstrated that Slit1alpha acts as a chemorepellent for olfactory bulb axon guidance, indicating it is a biologically active isoform specific to the vertebrate nervous system. RT-PCR, in situ hybridization, in vitro olfactory bulb chemorepulsion assay Journal of biochemistry Medium 15632296
2004 SLIT1 promoter CpG islands are hypermethylated in glioma tumor cell lines (5 out of 6; 83%), with much lower frequency in primary glioma tumors (2 out of 20; 10%), demonstrating that epigenetic silencing via promoter hypermethylation contributes to SLIT1 transcriptional downregulation in brain tumors. Bisulfite sequencing, methylation analysis, RT-PCR, 5-aza-2'-deoxycytidine re-expression assay British journal of cancer Medium 15534609
2005 Slit1 and Slit2 proteins are selective inhibitors and repellents for dorsally projecting cranial motor axons in the hindbrain, but not for ventrally projecting motor axons. Analysis of Slit/Robo-deficient mice showed cranial motor axons aberrantly enter the midline; ectopic Slit1 expression in chick caused specific motor axon projection errors; and dominant-negative Robo expression in chick motoneurons caused axons to enter the midline or fail to exit the hindbrain. In vitro explant repulsion assay, genetic knockout analysis, ectopic overexpression in chick, dominant-negative Robo in vivo Development (Cambridge, England) High 16162649
2006 Slit1 and its receptor Robo2 are dynamically upregulated in adult rat dorsal root ganglion (DRG) after peripheral nerve injury (sciatic transection) but not after central axon injury (dorsal rhizotomy). Slit1 protein is expressed in satellite cells surrounding primary sensory neurons and accumulates in traumatic neuroma after axotomy, suggesting a role in peripheral nerve regeneration that is injury type-specific. In situ hybridization, immunohistochemistry, western blot, DRG axotomy model Neuroscience research Medium 16979769
2007 Slit1 is required for zonal segregation of olfactory sensory neuron (OSN) axons along the dorsoventral axis of the olfactory bulb. In slit-1-/- mice, a subset of OSN axons that normally project to the dorsal olfactory bulb mistarget and form glomeruli in the ventral region. Robo-2 is expressed in OSNs in a high dorsomedial to low ventrolateral gradient, and Slit-1 and Slit-3 are expressed in the ventral olfactory bulb, defining a repulsive mechanism for dorsoventral OSN targeting. Genetic knockout (slit-1-/-, robo-2-/-), axon tracing, in situ hybridization The Journal of neuroscience High 17715346
2008 Robo2-Slit1 signaling mediates reciprocal cell-cell interactions between neural crest cells (which express Slit1) and placode cells (which express Robo2) required for trigeminal ganglion assembly in chick. Blocking Robo2 function or depleting either Robo2 or Slit1 by RNAi disrupted ganglion formation, mimicking neural crest ablation, establishing a novel role for Slit1 as a neural crest-derived ligand in cranial gangliogenesis. RNAi knockdown (Robo2 and Slit1), function-blocking antibodies, neural crest ablation, in ovo perturbation Nature neuroscience High 18278043
2009 N-cadherin acts in concert with Slit1-Robo2 signaling to mediate placodal cell adhesion during trigeminal gangliogenesis. Slit1-Robo2 signaling modulates N-cadherin protein levels on the placodal cell surface post-translationally (without changing total mRNA or protein). Co-expression of N-cadherin with dominant-negative Robo rescued the Robo2 loss-of-function phenotype, while N-cadherin loss reversed aberrant aggregation induced by increased Slit-Robo signaling. RNAi knockdown, dominant-negative receptor, overexpression, in ovo perturbation, epistasis analysis Development (Cambridge, England) High 19934013
2010 Recombinant soluble Slit1 protein promotes neurite outgrowth and elongation in adult rat dorsal root ganglion (DRG) neurons in vitro via binding to the Robo2 receptor. A recombinant human Robo2/Fc chimera competed with endogenous Robo2, inhibiting neurite outgrowth, and pre-treatment with Robo2/Fc chimera blocked Slit1-induced neurite growth, establishing Slit1-Robo2 as a signaling axis that promotes peripheral nerve regeneration. In vitro neurite outgrowth assay, recombinant protein treatment, competitive receptor blocking with Robo2/Fc chimera Journal of chemical neuroanatomy Medium 20172023
2010 SLIT1 mRNA is enriched in the prefrontal cortex of Old World monkeys compared to primary sensory areas. This area-specific enrichment emerges postnatally: SLIT1 is broadly expressed perinatally, then progressively downregulated in early sensory areas around postnatal day 60, followed by association areas, resulting in relative enrichment in prefrontal cortex. Robo1 and Robo2 are more uniformly distributed, suggesting SLIT1 has a specific postnatal role in prefrontal connectivity. Restriction landmark cDNA scanning, in situ hybridization (developmental time series in Old World monkeys) Cerebral cortex Low 20123755
2011 Sclerotome-derived Slit1 drives directional migration and fiber differentiation of Robo2-expressing pioneer myoblasts in avian embryos. Loss of Robo2 or sclerotome-derived Slit1 function perturbed directional cell migration and myofiber formation without affecting myoblast specification, and these effects were mediated through RhoA. Pioneer myoblasts express Robo2 downstream of MyoD and Myf5, and Slit1 is expressed in dermomyotome and caudal sclerotome. In ovo somite inversion, loss-of-function perturbations, expression analysis, RhoA pathway analysis Development (Cambridge, England) Medium 21653616
2011 The SH2/SH3 adaptor protein Nck2 (but not Nck1) binds to Robo receptors via an atypical SH3-mediated mechanism and is specifically required for Slit1-induced changes in cortical neuron morphology in vitro. Slit1 stimulates cortical dendrite branching and promotes axon elongation; neurons from Robo1/Robo2-deficient mice do not show Slit1-induced neurite growth, establishing Robo as the mediator. Nck2 knockdown selectively abrogates Slit1-driven morphological changes, linking Robo to cytoskeletal rearrangement. Co-immunoprecipitation (SH3-mediated Nck-Robo binding), RNAi knockdown of Nck1/Nck2, Robo1/2 knockout neurons, in vitro morphology assays Molecular and cellular neurosciences High 21600986
2013 Steerable-filter quantitative analysis of optic chiasm axons in Slit1-/-, Slit2-/-, and double mutant mice revealed that Slit2 alone can act to control aspects of retinal axon routing across the ventral diencephalon midline. Slit1 single mutants showed very few axon defects, while Slit2 single mutants showed previously unreported misorientation and anterior shift of chiasm axons, confirming cooperative but distinct roles for the two proteins. Steerable-filter image analysis of labeled axon populations, genetic knockout (single and double mutants) BMC neuroscience Medium 23320558
2015 At subrepellent (subthreshold) doses, Slit1 acts as a potent promoter of Netrin-1 chemotactic responses rather than as a repellent. On rostral thalamic axons, only a subthreshold concentration of Slit1 enabled an attractive response to a Netrin-1 gradient; on hippocampal neurons, subthreshold Slit1 triggered either attractive or repulsive responses to Netrin-1 depending on substrate. This combinatorial activity was demonstrated using a microfluidic gradient device with both dissociated neurons and explant cultures. Microfluidic gradient device, dissociated neuron cultures and explant cultures, quantitative axon turning assays Neural development High 25888985
2018 Fibroblast growth factor receptor 1 (Fgfr1) signaling transcriptionally regulates slit1 expression in a cell-autonomous manner. A 2.3 kb Fgfr1-responsive slit1 promoter sequence was identified that recapitulates endogenous spatiotemporal expression in the neural tube and eye of Xenopus embryos. Signaling through Fgfr1 (but not other Fgfr subtypes, even when co-expressed) specifically controls slit1 forebrain expression both in vitro and in vivo. Reporter gene assay (promoter-GFP in Xenopus), in vitro promoter activity in A6 cells, Fgfr subtype-specific manipulation, in vivo Xenopus forebrain expression analysis Cellular and molecular life sciences Medium 29705951
2018 SUV39H2, a histone H3 lysine 9 methyltransferase, directly binds the SLIT1 promoter and suppresses SLIT1 transcription by catalyzing H3K9 tri-methylation. SUV39H2 knockdown relieved SLIT1 repression, and rescue assays showed SLIT1 antagonizes SUV39H2-driven colorectal cancer proliferation and metastasis, establishing SLIT1 as a direct epigenetic target of SUV39H2. ChIP (SUV39H2 binding to SLIT1 promoter), H3K9me3 ChIP, siRNA knockdown, rescue overexpression, in vitro and in vivo cancer assays Cancer letters High 29458143
2019 ATP-P2X7 receptor signaling in satellite glial cells (SGCs) regulates Slit1 expression in dorsal root ganglia after peripheral nerve injury. After sciatic nerve crush, Slit1 expression increases first in neurons then with a time lag in surrounding SGCs, induced by contact with adjacent neuronal somas. Inhibition of P2X7 receptor with BBG reduced Slit1 expression in SGCs and increased VNUT (vesicular nucleotide transporter) in neurons, identifying the ATP-P2X7R pathway as a signal transduction mechanism from injured neurons to SGCs that drives Slit1 upregulation. Immunohistochemistry, western blot, fluorescent gold retrograde tracing, double immunofluorescence, P2X7R inhibitor injection in vivo Frontiers in cellular neuroscience Medium 31607866
2020 Slit1 protein regulates the mobilization of SVZ-derived neural precursor cells (NPCs) after CNS demyelination. In Slit1-/- mice, the number of SVZ-NPCs recruited to demyelinating corpus callosum lesions is increased, leading to higher numbers of Olig2+ cells within the lesion. Time-lapse video-microscopy showed Slit1-deficient NPCs migrate faster and make more frequent directional changes than controls, supporting a cell-autonomous mechanism. Slits and Robos are also transcriptionally regulated in the SVZ in response to demyelination. Slit1 knockout mice, lysolecithin-induced demyelination model, SVZ microdissection, RT-PCR, time-lapse video-microscopy of immunopurified NPCs, immunohistochemistry Frontiers in cellular neuroscience High 32670024
2020 Lhx2 functions as an indirect repressor of slit1 expression in the Xenopus forebrain: Lhx2 overexpression downregulates slit1 mRNA and decreases slit1 promoter activity in vitro; the constitutive repressor fusion Lhx2-En increases slit1 induction. Conversely, Etv1 gain-of-function transactivates slit1 both in vitro and in the forebrain. Together, Lhx2/9 and Etv1 act as complementary downstream effectors of Fgf signaling to establish proper slit1 expression boundaries. Promoter-reporter assay, gain-of-function overexpression, constitutive activator/repressor fusion constructs, in vivo Xenopus forebrain expression analysis Neuroscience Medium 32200077
2021 SLIT1 is downregulated specifically in the ventromedial prefrontal cortex (vmPFC) of women (but not men) with depression. Knockdown of Slit1 in vmPFC of female mice combined with stress induced sex-specific increases in anxiety- and depression-related behaviors, decreased dendritic arborization of pyramidal neurons, and decreased neuronal excitability—effects not observed in males. RNA sequencing after Slit1 knockdown revealed an augmented transcriptional stress signature in females. Viral-mediated Slit1 knockdown in vmPFC, chronic variable stress, behavioral testing, electrophysiology, dendritic morphology analysis, RNA sequencing Biological psychiatry High 33896623
2022 miR-640 targets SLIT1 and the miR-640-SLIT1 axis regulates radiosensitivity of glioma cells through the Wnt/β-catenin signaling pathway. SLIT1 knockdown reduced radioresistance, migration, and invasion while increasing apoptosis. Loss of miR-640 activity upregulated SLIT1, Wnt, and β-catenin protein expression and inhibited p-GSK-3β, suggesting SLIT1 activates Wnt/β-catenin signaling to promote glioma radioresistance. siRNA knockdown, miRNA inhibitor transfection, western blot, CCK-8 proliferation assay, wound healing, transwell invasion, caspase-3 assay British journal of biomedical science Medium 35996510
2024 Slit1 inhibits ovarian follicle development and female fertility in mice via an autocrine/paracrine mechanism. Slit1-null female mice produce larger litters due to increased ovulation rates and greater numbers of healthy antral follicles. Exogenous SLIT1 induces granulosa cell apoptosis and inhibits gonadotropin-stimulated AKT phosphorylation. SLIT1 pretreatment of cultured granulosa cells inhibited both FSH- and LH-induced AKT phosphorylation, identifying SLIT1 as a novel antagonist of gonadotropin-AKT signaling in the ovary. Slit1 knockout mice, granulosa cell culture, exogenous recombinant SLIT1 treatment, AKT phosphorylation assays, apoptosis assays, follicle counting, ovulation rate measurement Biology of reproduction High 38943353
2024 Slit1 promotes hypertrophic scar (HTS) formation through TGF-β signaling. Recombinant Slit1 treatment of normal human fibroblasts promoted cell proliferation, differentiation (increased α-SMA, collagen I/III, fibronectin), migration (with increased N-cadherin and vimentin, decreased E-cadherin), and activated both SMAD pathway proteins (SMAD2, SMAD3, SMAD1/5/8) and non-SMAD pathway proteins (TAK1, JNK1, ERK1/2, p38). Recombinant human Slit1 protein treatment, western blot, RT-qPCR, cell viability assay, scratch migration assay, phospho-protein analysis Medicina (Kaunas, Lithuania) Medium 39768930
2025 Neuronal Slit1 secreted from hypoxic neurons directly targets oligodendrocyte precursor cells (OPCs) via Robo2-srGAP1-RhoA signaling to promote oligodendrocyte differentiation and myelination. Conditional ablation of Slit1 in neurons exacerbated hypoxia-induced hypomyelination and motor/cognitive deficits. Pharmacological RhoA inhibition restored myelination in adolescent mice. A natural variant with higher Slit1 expression was identified in Tibetan populations adapted to low oxygen, validating the pathway's physiological importance. Conditional neuron-specific Slit1 knockout, chronic hypoxia mouse model, pharmacological RhoA inhibition, behavioral testing, pathway analysis (Robo2-srGAP1-RhoA), natural selection/population genetics analysis Cell reports High 40117292
2025 SLIT1 and SLIT2 share redundant functions and mechanisms of action in ovarian granulosa cells. RNA-seq showed SLIT1 upregulated 612 and downregulated 601 genes in granulosa cells. SLIT1 antagonizes FSH- (but not LH-) induced FOXO1 phosphorylation; SLIT2 (but not SLIT3) similarly antagonizes FSH-stimulated AKT and FOXO1 signaling. Both SLIT1 and SLIT2 induce granulosa cell apoptosis. Loss of ROBO1 did not inhibit SLIT1 or SLIT2 AKT/FOXO1 antagonism, indicating ROBO1 is not the sole receptor. RNA-seq, exogenous recombinant SLIT1/2/3 treatment, AKT and FOXO1 phosphorylation assays, Robo1 knockout granulosa cells, apoptosis assays Reproduction (Cambridge, England) High 40996529

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 1451 20881960
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2014 Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature 445 25231870
2002 Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Neuron 351 11804570
2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome research 285 12975309
2002 Spatiotemporal expression patterns of slit and robo genes in the rat brain. The Journal of comparative neurology 212 11754167
2009 Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Gut 157 19240061
1998 Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. Brain research. Molecular brain research 152 9813312
1998 Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening. Genomics 148 9693030
2009 Repulsive axon guidance molecule Slit3 is a novel angiogenic factor. Blood 132 19741192
1998 Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis. Mechanisms of development 131 10349621
2018 Osteoclast-secreted SLIT3 coordinates bone resorption and formation. The Journal of clinical investigation 127 29504949
2004 Epigenetic inactivation of SLIT3 and SLIT1 genes in human cancers. British journal of cancer 122 15534609
2003 Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction. Development (Cambridge, England) 119 12642493
2008 SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium. Cancer research 110 18829537
2010 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Molecular medicine (Cambridge, Mass.) 108 20379614
2018 Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Molecular & cellular proteomics : MCP 101 30021884
2003 Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice. Mechanisms of development 100 14550534
2004 Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding. Molecular and cellular neurosciences 96 15207848
2021 Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue. Nature metabolism 94 34782792
2007 Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience 93 17715346
2016 FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. PLoS biology 82 26752685
2013 Down-regulation of miR-218-2 and its host gene SLIT3 cooperate to promote invasion and progression of thyroid cancer. The Journal of clinical endocrinology and metabolism 79 23720784
2014 Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Human molecular genetics 77 25429064
2005 Expression of netrin-1, slit-1 and slit-3 but not of slit-2 after cerebellar and spinal cord lesions. The European journal of neuroscience 73 16262652
2009 N-cadherin acts in concert with Slit1-Robo2 signaling in regulating aggregation of placode-derived cranial sensory neurons. Development (Cambridge, England) 72 19934013
2008 Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion. Nature neuroscience 72 18278043
2001 Expression of slit-2 and slit-3 during chick development. Developmental dynamics : an official publication of the American Association of Anatomists 71 11668607
2006 Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits. Stem cells (Dayton, Ohio) 68 16840550
2021 Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Acta pharmaceutica Sinica. B 66 35256949
2005 Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain. Development (Cambridge, England) 64 16162649
2019 Retracted: Macrophage-Derived Slit3 Controls Cell Migration and Axon Pathfinding in the Peripheral Nerve Bridge. Cell reports 63 30726731
2014 Estrogen receptor (ER) agonists differentially regulate neuroangiogenesis in peritoneal endometriosis via the repellent factor SLIT3. Endocrinology 63 25051436
2002 Slit1 and slit2 proteins control the development of the lateral olfactory tract. The Journal of neuroscience : the official journal of the Society for Neuroscience 58 12097499
2022 Angelica sinensis polysaccharide improves rheumatoid arthritis by modifying the expression of intestinal Cldn5, Slit3 and Rgs18 through gut microbiota. International journal of biological macromolecules 57 35318077
2010 Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer, a case-control study in Chinese women. Gynecologic oncology 55 20163849
2013 SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo. Journal of molecular and cellular cardiology 53 24090675
2008 Novel regulated expression of the SLIT/ROBO pathway in the ovary: possible role during luteolysis in women. Endocrinology 50 18566128
2003 Irx4-mediated regulation of Slit1 expression contributes to the definition of early axonal paths inside the retina. Development (Cambridge, England) 49 12571096
2010 Duplication of the SLIT3 locus on 5q35.1 predisposes to major depressive disorder. PloS one 47 21152026
2022 NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. Nature immunology 46 36138187
2018 SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter. Cancer letters 46 29458143
2010 The chemorepellent Slit3 promotes monocyte migration. Journal of immunology (Baltimore, Md. : 1950) 43 21078908
2011 Expression and roles of Slit/Robo in human ovarian cancer. Histochemistry and cell biology 42 21465248
2003 Two divergent slit1 genes in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists 42 14579375
2001 Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons. Development (Cambridge, England) 40 11748139
2015 Effects of Slit3 silencing on the invasive ability of lung carcinoma A549 cells. Oncology reports 35 26045181
2020 Osteoclasts are not a source of SLIT3. Bone research 33 32133214
2004 Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population. Genome research 33 15231749
2011 Slit3 inhibits activator protein 1-mediated migration of malignant melanoma cells. International journal of molecular medicine 30 21743955
2015 Function of Slit/Robo signaling in breast cancer. Frontiers of medicine 29 26542734
2012 Control of human hematopoietic stem/progenitor cell migration by the extracellular matrix protein Slit3. Laboratory investigation; a journal of technical methods and pathology 29 22614124
2013 Experimental validation of 5 in-silico predicted glioma biomarkers. Neuro-oncology 28 24158112
2020 Dynamic expression of Slit1-3 and Robo1-2 in the mouse peripheral nervous system after injury. Neural regeneration research 27 31719262
2007 Slit3 regulates cell motility through Rac/Cdc42 activation in lipopolysaccharide-stimulated macrophages. FEBS letters 27 17306799
2001 Slit1 is specifically expressed in the primary and secondary enamel knots during molar tooth cusp formation. Mechanisms of development 27 11520671
2006 Dynamic changes in Robo2 and Slit1 expression in adult rat dorsal root ganglion and sciatic nerve after peripheral and central axonal injury. Neuroscience research 26 16979769
2005 Comparative genomics on SLIT1, SLIT2, and SLIT3 orthologs. Oncology reports 26 16211308
2021 Anti-Tumor Effect of Celastrol on Hepatocellular Carcinoma by the circ_SLIT3/miR-223-3p/CXCR4 Axis. Cancer management and research 25 33574707
2021 SLIT3 promotes myogenic differentiation as a novel therapeutic factor against muscle loss. Journal of cachexia, sarcopenia and muscle 25 34423586
2010 Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis. Arthritis research & therapy 25 20298552
2020 Rac1 Inhibition Via Srgap2 Restrains Inflammatory Osteoclastogenesis and Limits the Clastokine, SLIT3. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 24 31880824
2016 Specific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes. International journal of oncology 24 27082735
2021 Sex-Specific Role for SLIT1 in Regulating Stress Susceptibility. Biological psychiatry 23 33896623
2020 SLIT3 deficiency attenuates pressure overload-induced cardiac fibrosis and remodeling. JCI insight 22 32644051
2023 Human umbilical cord mesenchymal stem cells inhibit liver fibrosis via the microRNA-148a-5p/SLIT3 axis. International immunopharmacology 21 37918086
2001 Dual trafficking of Slit3 to mitochondria and cell surface demonstrates novel localization for Slit protein. American journal of physiology. Cell physiology 20 11443047
2011 Sclerotome-derived Slit1 drives directional migration and differentiation of Robo2-expressing pioneer myoblasts. Development (Cambridge, England) 19 21653616
2020 Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour. eLife 18 32209227
2018 High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increased insulin resistance and interacted with coffee and caffeine consumption in middle-aged adults. Nutrition, metabolism, and cardiovascular diseases : NMCD 18 30454882
2015 Subrepellent doses of Slit1 promote Netrin-1 chemotactic responses in subsets of axons. Neural development 18 25888985
2022 Protective effect of Du-Zhong-Wan against osteoporotic fracture by targeting the osteoblastogenesis and angiogenesis couple factor SLIT3. Journal of ethnopharmacology 17 35649495
2018 Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway. BMC cancer 17 29859044
2023 Targeting soluble epoxide hydrolase promotes osteogenic-angiogenic coupling via activating SLIT3/HIF-1α signalling pathway. Cell proliferation 16 36636821
2018 Implication of SLIT3-ROBO1/ROBO2 in granulosa cell proliferation, differentiation and follicle selection in the prehierarchical follicles of hen ovary. Cell biology international 16 30288875
2013 SLIT3 is increased in supracervical human foetal membranes and in labouring myometrium and regulates pro-inflammatory mediators. American journal of reproductive immunology (New York, N.Y. : 1989) 16 24286238
2008 Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. PloS one 16 18628988
2010 Slit1 promotes regenerative neurite outgrowth of adult dorsal root ganglion neurons in vitro via binding to the Robo receptor. Journal of chemical neuroanatomy 15 20172023
2013 Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3. PloS one 14 23536828
2012 The C-terminal fragment of axon guidance molecule Slit3 binds heparin and neutralizes heparin's anticoagulant activity. Glycobiology 14 22641771
2011 The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology. Molecular and cellular neurosciences 14 21600986
2023 An angiogenic approach to osteoanabolic therapy targeting the SHN3-SLIT3 pathway. Bone 12 37030497
2020 Tissue-specific angiogenic and invasive properties of human neonatal thymus and bone MSCs: Role of SLIT3-ROBO1. Stem cells translational medicine 12 32470195
2009 Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry. BMC medical genetics 12 19228371
2002 Conserved modularity and potential for alternate splicing in mouse and human Slit genes. The International journal of developmental biology 11 12141424
2024 Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy. Circulation research 10 38414132
2024 Sarsasapogenin stimulates angiogenesis and osteogenesis coupling to treat estrogen deficiency-induced osteoporosis by activating the GPX4/SLIT3/ROBO1 axis. Phytomedicine : international journal of phytotherapy and phytopharmacology 10 39637471
2022 Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis. Scientific reports 10 35288626
2020 Morphogenesis of the Islets of Langerhans Is Guided by Extraendocrine Slit2 and Slit3 Signals. Molecular and cellular biology 10 33318057
2018 Osteoclast-derived SLIT3 is a coupling factor linking bone resorption to bone formation. BMB reports 10 29764562
2012 Repulsive axon guidance cues ephrin-A2 and slit3 stop protrusion of the growth cone leading margin concurrently with inhibition of ADF/cofilin and ERM proteins. Cytoskeleton (Hoboken, N.J.) 10 22328420
2010 Prefrontal-enriched SLIT1 expression in Old World monkey cortex established during the postnatal development. Cerebral cortex (New York, N.Y. : 1991) 10 20123755
2024 The Role of SLIT3-ROBO4 Signaling in Endoplasmic Reticulum Stress-Induced Delayed Corneal Epithelial and Nerve Regeneration. Investigative ophthalmology & visual science 9 38700874
2018 Sex-Dependent Motor Deficit and Increased Anxiety-Like States in Mice Lacking Autism-Associated Gene Slit3. Frontiers in behavioral neuroscience 9 30483073
2015 Heparan sulfate modulates Slit3-induced endothelial cell migration. Methods in molecular biology (Clifton, N.J.) 9 25325980
2014 A subset of chicken statoacoustic ganglion neurites are repelled by Slit1 and Slit2. Hearing research 9 24456709
2004 Expression and function of Slit1alpha, a novel alternative splicing product for slit1. Journal of biochemistry 9 15632296
2023 SLIT3-mediated fibroblast signaling: a promising target for antifibrotic therapies. American journal of physiology. Heart and circulatory physiology 8 37830982
2020 Slit1 Protein Regulates SVZ-Derived Precursor Mobilization in the Adult Demyelinated CNS. Frontiers in cellular neuroscience 8 32670024
2018 Fibroblast growth factor receptor 1 signaling transcriptionally regulates the axon guidance cue slit1. Cellular and molecular life sciences : CMLS 8 29705951
2012 Fragments of SLIT3 inhibit cellular migration. International journal of molecular medicine 8 22922792
2022 LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer by Regulating miR-587/SLIT3 Axis. Critical reviews in eukaryotic gene expression 7 36017912
2020 Lhx2/9 and Etv1 Transcription Factors have Complementary roles in Regulating the Expression of Guidance Genes slit1 and sema3a. Neuroscience 7 32200077
2019 The ATP-P2X7 Signaling Pathway Participates in the Regulation of Slit1 Expression in Satellite Glial Cells. Frontiers in cellular neuroscience 7 31607866
2023 Expression and Predictive Significance of FHL1 and SLIT3 in Surgically Resected Lung Adenocarcinoma. Combinatorial chemistry & high throughput screening 6 36752296
2022 Micro RNA-640 Targeting SLIT1 Enhances Glioma Radiosensitivity by Restraining the Activation of Wnt/β-Catenin Signaling Pathway. British journal of biomedical science 6 35996510
2020 Wnt Signaling Regulates Ipsilateral Pathfinding in the Zebrafish Forebrain through slit3. Neuroscience 6 32949671
2019 Gingival crevicular fluid levels of SLIT3 are increased in periodontal disease. Oral diseases 6 31696592
2025 A neuronal Slit1-dependent program rescues oligodendrocyte differentiation and myelination under chronic hypoxic conditions. Cell reports 5 40117292
2023 Concomitant induction of SLIT3 and microRNA-218-2 in macrophages by toll-like receptor 4 activation limits osteoclast commitment. Cell communication and signaling : CCS 5 37596575
2020 Single-nucleotide polymorphism rs10036727 in the SLIT3 gene is associated with osteoporosis at the femoral neck in older Mexican postmenopausal women. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 5 32762475
2024 SLIT3 promotes cardiac fibrosis and differentiation of cardiac fibroblasts by RhoA/ROCK1 signaling pathway. Iranian journal of basic medical sciences 4 38800023
2024 Inhibition of Slit3/Robo1 signaling alleviates osteoarthritis in mice by reducing abnormal H-type vessel formation in subchondral bone. Immunopharmacology and immunotoxicology 4 39510846
2023 Association of SLIT3 and ZNF280B Gene Polymorphisms with Wool Fiber Diameter. Animals : an open access journal from MDPI 4 38003169
2022 Zebrafish Slit2 and Slit3 Act Together to Regulate Retinal Axon Crossing at the Midline. Journal of developmental biology 4 36278546
2021 Isolated congenital diaphragm hernia associated with homozygous SLIT3 gene variant in dizygous twins. European journal of medical genetics 4 33933663
2013 Steerable-filter based quantification of axonal populations at the developing optic chiasm reveal significant defects in Slit2(-/-) as well as Slit1(-/-)Slit2(-/-) embryos. BMC neuroscience 4 23320558
2024 Slit1 inhibits ovarian follicle development and female fertility in mice†. Biology of reproduction 2 38943353
2021 Controlled Delivery of Slit3 Proteins from Alginate Microbeads Inhibits In Vitro Angiogenesis. The Journal of surgical research 2 33794389
2018 Slit3 regulates migration of endothelial progenitor cells by activation of the RhoA/Rho kinase pathway. International journal of clinical and experimental pathology 2 31949717
2016 [Expression of Slit3/Robo signal pathway in mouse aortic smooth muscle cell and its impact on proliferation and migration]. Zhonghua xin xue guan bing za zhi 2 27346270
2014 Changes in expression of Slit1 and its receptor Robo2 in trigeminal ganglion and inferior alveolar nerve following inferior alveolar nerve axotomy in adult rats: a pilot study. International journal of oral and maxillofacial surgery 2 25457824
2025 Redundant functions and mechanisms of action of Slit1 and Slit2 in ovarian granulosa cells. Reproduction (Cambridge, England) 1 40996529
2024 Slit3 by PTH-Induced Osteoblast Secretion Repels Sensory Innervation in Spine Porous Endplates to Relieve Low Back Pain. Research square 1 39257984
2024 SLIT3 deficiency promotes non-small cell lung cancer progression by modulating UBE2C/WNT signaling. Open life sciences 1 39479352
2024 Slit1 Promotes Hypertrophic Scar Formation Through the TGF-β Signaling Pathway. Medicina (Kaunas, Lithuania) 1 39768930
2025 Slit3 Fragments Orchestrate Neurovascular Expansion and Thermogenesis in Brown Adipose Tissue. bioRxiv : the preprint server for biology 0 39386533
2025 Osteoclast-Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 0 41255240