Affinage

SLC27A4

Long-chain fatty acid transport protein 4 · UniProt Q6P1M0

Length
643 aa
Mass
72.1 kDa
Annotated
2026-06-10
49 papers in source corpus 23 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC27A4 (FATP4) is an endoplasmic reticulum-localized very long-chain acyl-CoA synthetase that governs cellular fatty acid handling by esterifying fatty acids to acyl-CoAs, thereby driving fatty acid uptake indirectly through metabolic trapping rather than direct plasma-membrane translocation (PMID:11404000, PMID:17062637). Its enzyme is biased toward very long-chain substrates (e.g. C24:0) over long-chain fatty acids, is insensitive to triacsin C, and is feedback-inhibited by acyl-CoA (PMID:11404000, PMID:15653672). ER residence with activity-dependent uptake enhancement has been confirmed across muscle, hepatoma, and adipocyte cell models (PMID:17062637, PMID:21750264, PMID:22022213, PMID:23024797). In skin, FATP4 acyl-CoA synthetase activity in suprabasal keratinocytes is essential for epidermal permeability barrier formation: it activates ω-hydroxy fatty acids for acylceramide synthesis, and its loss abolishes acylceramides and causes hyperproliferative hyperkeratosis with a defective barrier, downstream of which EGFR-STAT3 signaling is aberrantly activated (PMID:12821645, PMID:16354193, PMID:17401141, PMID:31974308, PMID:20513444). Beyond skin, FATP4 channels fatty acids into distinct lipid pools in a tissue-specific manner—partitioning toward complex/polar lipids in adipocytes, macrophages, and enterocytes—so that its loss shifts metabolism toward neutral lipids (triacylglycerides) and alters inflammatory output and plasma lipid levels (PMID:21808061, PMID:33900381, PMID:38915276). It interacts with PLIN5 at lipid droplet-mitochondria contact sites to supply acyl-CoAs for β-oxidation (PMID:37290445), negatively regulates RPE65 isomerase activity in the visual cycle by substrate competition and C24:0-CoA production (PMID:23407971), and in liver drives phosphatidylcholine accumulation that activates PXR in a feedforward loop promoting steatosis (PMID:39489412). In cancer contexts it has been linked to MUFA-dependent ferroptosis resistance and to ATG4B-mediated autophagy (PMID:36924851, PMID:26662804).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2001 High

    Established that FATP4 is an enzyme—a very long-chain acyl-CoA synthetase—rather than a passive transporter, defining its core biochemical activity.

    Evidence Transfection of FATP4 cDNA into COS1 cells with acyl-CoA synthetase activity assays on membrane extracts

    PMID:11404000

    Open questions at the time
    • Did not define subcellular site of activity
    • Did not establish physiological substrate preference in vivo
  2. 2003 High

    Demonstrated an essential in vivo function in epidermal barrier formation, linking FATP4 loss to defective ceramide fatty acid composition.

    Evidence Targeted Fatp4 knockout mice with histology and epidermal ceramide lipid analysis

    PMID:12821645

    Open questions at the time
    • Could not distinguish keratinocyte-intrinsic from systemic effects
    • Molecular target lipid in ceramide synthesis not yet defined
  3. 2005 High

    Resolved substrate specificity and confirmed enzymatic identity using purified protein plus knockout tissue, showing preferential activation of very long-chain fatty acids in vivo.

    Evidence Affinity-purified FLAG-FATP4 kinetics and acyl-CoA synthetase assays in knockout skin/intestine extracts

    PMID:15653672

    Open questions at the time
    • Did not address localization
    • Mechanism of feedback inhibition not structurally defined
  4. 2006 High

    Established that FATP4 enhances fatty acid uptake indirectly via ER-based metabolic trapping (esterification), settling the transporter-versus-enzyme question of how uptake is driven.

    Evidence Immunofluorescence localization, single-cell uptake assays, and ACS-activity mutant analysis

    PMID:17062637

    Open questions at the time
    • Did not rule out tissue-specific plasma-membrane pools
    • Quantitative contribution to whole-body FA flux unaddressed
  5. 2005 High

    Showed keratinocyte-intrinsic FATP4 deficiency suffices for the skin phenotype and that its ACS catalytic activity is required, linking enzyme function directly to barrier development.

    Evidence Keratinocyte-specific conditional knockout and transgenic rescue with wild-type versus ACS-domain mutant FATP4

    PMID:16354193 PMID:17401141

    Open questions at the time
    • Specific lipid substrate in keratinocytes not yet identified
    • Downstream signaling consequences not defined
  6. 2010 Medium

    Placed FATP4 activity upstream of EGFR-STAT3 signaling, connecting a metabolic lipid defect to a proliferative signaling cascade in skin.

    Evidence Expression profiling in mutant skin plus pharmacological EGFR/STAT3 inhibition with phenotypic rescue

    PMID:20513444

    Open questions at the time
    • Causal lipid linking FATP4 loss to EGF ligand induction unidentified
    • Pharmacological inhibitors lack genetic confirmation
  7. 2011 Medium

    Generalized ER localization and metabolic-trapping uptake mechanism across muscle, hepatoma, and adipocyte cells, and linked insulin to acute regulation of FATP4 enzymatic activity.

    Evidence Stable overexpression, fractionation/confocal localization, ACS and FA-uptake assays with insulin/wortmannin treatment

    PMID:21750264 PMID:22022213 PMID:23024797

    Open questions at the time
    • Molecular mechanism of insulin-induced activity increase not defined
    • Phosphorylation or modification of FATP4 not directly demonstrated
  8. 2011 High

    Demonstrated FATP4 is dispensable for adipocyte fatty acid uptake but shapes complex lipid metabolism, refining the view that its role is biosynthetic partitioning rather than bulk uptake.

    Evidence Adipocyte-specific knockout with radiolabeled uptake assays and lipidomics under high-fat diet

    PMID:21808061

    Open questions at the time
    • Redundant transporters compensating for uptake unidentified
    • Mechanism linking loss to adipose hypertrophy unclear
  9. 2013 High

    Identified FATP4 as a negative regulator of the RPE65 visual cycle isomerase, expanding its role beyond bulk lipid metabolism to enzyme-level regulation via substrate competition and product (C24:0-CoA) inhibition.

    Evidence Expression cloning, FATP4-deficient RPE isomerase and retinoid analyses, and electrophysiology

    PMID:23407971

    Open questions at the time
    • Physical interaction with RPE65 not established
    • Relative weight of competition versus C24:0-CoA inhibition unquantified
  10. 2012 Medium

    Provided in situ evidence that FATP4 functions in proximity to NIPAL4/ichthyin in epidermis, implicating a coordinated lipid-processing module in barrier formation.

    Evidence Proximity ligation assay in human skin and organotypic epidermis with siRNA silencing

    PMID:23290633

    Open questions at the time
    • PLA proximity does not prove direct binding
    • Functional consequence of the interaction not biochemically defined
  11. 2020 High

    Pinpointed the biochemical substrate explaining the skin phenotype: FATP4 activates ω-hydroxy fatty acids for acylceramide synthesis essential for the permeability barrier.

    Evidence In vitro ACS assay with ω-hydroxy fatty acid substrate, knockout mouse lipidomics, and human keratinocyte knockdown

    PMID:31974308

    Open questions at the time
    • Mechanism coupling FATP4 to ELOVL1 expression unclear
    • Structural basis of ω-hydroxy substrate recognition unknown
  12. 2021 Medium

    Showed FATP4 controls macrophage lipid partitioning and inflammatory output, linking its ACS activity to ceramide production and IRE1α-dependent cytokine release.

    Evidence THP-1 knockdown and macrophage-specific knockout BMDMs with lipidomics, cytokine, and UPR analyses

    PMID:33900381

    Open questions at the time
    • Mechanism connecting FATP4 lipids to selective IRE1α activation undefined
    • Single lab without independent replication
  13. 2023 High

    Defined a direct PLIN5-FATP4 interaction tethering lipid droplets to mitochondria to channel fatty acids into β-oxidation, establishing a contact-site role in fuel delivery.

    Evidence Reciprocal Co-IP, C-terminal domain mapping, contact-site imaging, and β-oxidation assays in myoblasts

    PMID:37290445

    Open questions at the time
    • Mitochondrial pool of FATP4 versus ER pool not fully resolved
    • Regulation of the interaction beyond starvation/phosphorylation unclear
  14. 2024 High

    Established hepatic and intestinal FATP4 as drivers of systemic lipid pathology—via a phosphatidylcholine-PXR feedforward loop in liver and polar/neutral lipid balance in the ileum controlling plasma lipids.

    Evidence Hepatocyte- and enterocyte-specific knockouts plus AAV overexpression with lipidomics, RNA-seq, and PXR genetic epistasis

    PMID:38915276 PMID:39489412

    Open questions at the time
    • Mechanism of PC-mediated PXR activation not structurally defined
    • Translation of mouse intestinal findings to human lipid disorders unaddressed
  15. 2023 Medium

    Linked FATP4 to cancer cell survival through MUFA-driven membrane composition conferring ferroptosis resistance and through ATG4B-stabilized autophagy.

    Evidence Lipidomics with overexpression/knockdown and ferroptosis assays in HCC; TAP/MS and reciprocal pulldown with ATG4B in lung cancer cells

    PMID:26662804 PMID:36924851

    Open questions at the time
    • ATG4B interaction tested only in cancer cell lines without in vivo validation
    • Whether autophagy role depends on ACS activity unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How FATP4's single acyl-CoA synthetase activity is differentially routed to distinct lipid fates (acylceramides, complex phospholipids, β-oxidation, PXR-activating PC) across tissues, and the structural basis of its substrate selectivity and protein partnerships, remain unresolved.
  • No crystal/cryo-EM structure to explain VLCFA selectivity
  • Mechanism selecting biosynthetic versus catabolic acyl-CoA channeling unknown
  • Direct partners beyond PLIN5/ATG4B largely uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016874 ligase activity 4 GO:0005215 transporter activity 3 GO:0016740 transferase activity 3
Localization
GO:0005783 endoplasmic reticulum 4 GO:0005739 mitochondrion 1 GO:0005811 lipid droplet 1
Pathway
R-HSA-1430728 Metabolism 5 R-HSA-1266738 Developmental Biology 4 R-HSA-9612973 Autophagy 1 R-HSA-9709957 Sensory Perception 1
Partners
ATG4BNIPAL4PLIN5RPE65

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 FATP4 encodes a very long chain acyl-CoA synthetase with substrate specificity biased towards very long chain fatty acids; transfection of FATP4 cDNA into COS1 cells produced a 2-fold increase in palmitoyl-CoA synthetase (C16:0) activity and a 5-fold increase in lignoceroyl-CoA synthetase (C24:0) activity from membrane extracts. Transfection of FATP4 cDNA into COS1 cells with enzymatic activity assays on membrane extracts Gene High 11404000
2003 Fatp4 knockout mice display neonatally lethal restrictive dermopathy with hyperproliferative hyperkeratosis, disturbed epidermal barrier, and a disturbed fatty acid composition of epidermal ceramides (specifically decreased C26:0 and C26:0-OH fatty acid substitutes), establishing an essential function of Fatp4 in epidermal barrier formation. Targeted gene disruption (knockout mouse), histology, lipid analysis of epidermal ceramides The Journal of cell biology High 12821645
2005 Purified FATP4 is an acyl-CoA synthetase with kinetic activity for both long chain (C16:0) and very long chain (C24:0) fatty acids; it is insensitive to triacsin C inhibition but sensitive to feedback inhibition by acyl-CoA. Extracts from skin and intestine of FATP4 null mice showed reduced esterification specifically for C24:0 but not C16:0 or C18:1, suggesting FATP4 preferentially activates very long chain fatty acids in vivo. Affinity purification of FLAG-tagged FATP4, kinetic enzymatic assays, acyl-CoA synthetase activity in tissue extracts from knockout mice The Journal of biological chemistry High 15653672
2005 Epidermal keratinocyte-specific inactivation of Fatp4 reproduces the hyperproliferative hyperkeratosis and disturbed epidermal barrier seen in global Fatp4 knockouts, establishing that intrinsic Fatp4 deficiency in keratinocytes (not secondary loss in other organs) is responsible for the epidermal structural abnormalities. Conditional keratinocyte-specific Fatp4 knockout (Cre-lox), histology, epidermal barrier assays The Journal of investigative dermatology High 16354193
2006 FATP4 localizes to the endoplasmic reticulum (not the plasma membrane), and its enhancement of cellular fatty acid uptake is dependent on its acyl-CoA synthetase enzymatic activity; ER-localized FATP4 drives fatty acid uptake indirectly by esterification (metabolic trapping) rather than by direct translocation at the plasma membrane. Immunofluorescence localization, quantitative fatty acid uptake assays at single-cell level, enzymatic activity mutant analysis, expression of mitochondrial acyl-CoA synthetase as control Journal of cell science High 17062637
2007 Keratinocyte-specific expression of FATP4 rescues the neonatally lethal skin phenotype of Fatp4-/- mice, while expression of an FATP4 variant with mutations in the acyl-CoA synthetase domain fails to rescue, establishing that the acyl-CoA synthetase activity of FATP4 in suprabasal keratinocytes is necessary for normal skin development and cornified envelope formation. Transgenic rescue experiments (wild-type and ACS-domain mutant FATP4), tetraploid aggregation, phenotypic analysis of skin barrier The Journal of biological chemistry High 17401141
2009 Independent overexpression of FATP4 in rat skeletal muscle increases fatty acid transport; FATP4 is 1.7-fold more effective than FABPpm and FATP1 at enhancing fatty acid transport. All transporters increased long chain fatty acid oxidation, but FABPpm and FAT/CD36 had 3-fold greater effects on oxidation than FATP1 and FATP4. FATP4 overexpression did not alter rates of fatty acid esterification into triacylglycerols. In vivo electroporation-mediated overexpression in rat skeletal muscle, fatty acid transport assays, oxidation and esterification measurements The Journal of biological chemistry Medium 19380575
2010 FATP4-deficient epidermis exhibits increased expression of EGF family members (Ereg, Areg, Epgn) associated with elevated EGFR activation and downstream STAT3 signaling in suprabasal cells; pharmacological inhibition of EGFR or STAT3 attenuated STAT3 activation and partially suppressed skin thickening and barrier abnormalities, placing FATP4 activity upstream of EGFR-STAT3 signaling in skin development. Gene expression profiling in Fatp4 mutant skin, EGFR/STAT3 activation assays, pharmacological inhibition (Tyrphostin AG1478, curcumin) with phenotypic readout Developmental biology Medium 20513444
2011 FATP4 localizes to the endoplasmic reticulum (not plasma membrane) in C2C12 muscle cells; stable FATP4 overexpression doubles acyl-CoA synthetase activity and cellular oleate uptake. Insulin treatment increases acyl-CoA synthetase activity within minutes in a wortmannin-sensitive manner, and affinity-purified FATP4 from insulin-treated cells shows enhanced enzyme activity, suggesting insulin regulation of FATP4 enzymatic activity as a mechanism for insulin-stimulated fatty acid uptake. Stable overexpression, acyl-CoA synthetase activity assays, subcellular fractionation and immunofluorescence, insulin treatment with wortmannin inhibition, affinity purification of FATP4 from insulin-treated cells American journal of physiology. Endocrinology and metabolism Medium 21750264
2011 FATP2 and FATP4 localize to the ER in HuH7 and HepG2 hepatoma cells; overexpression of FATP4 increases acyl-CoA synthetase activity and enhances uptake of [3H]-oleic acid and fluorescent Bodipy-C12 fatty acid, consistent with ER-based metabolic trapping as the mechanism for FA uptake enhancement. Immunofluorescence localization, overexpression, acyl-CoA synthetase activity assays, radiolabeled and fluorescent fatty acid uptake assays, quantitative FACS International journal of medical sciences Medium 22022213
2011 Adipocyte-specific Fatp4 knockout mice show no change in fatty acid uptake into adipose tissue under standard conditions, establishing that FATP4 is not required for fatty acid uptake in adipocytes. Under high-fat diet, Fatp4-deficient adipocytes show altered metabolism of complex lipids (decreased phospholipids, sphingomyelin, and cholesteryl esters) with adipose hypertrophy. Adipocyte-specific Cre-lox knockout, radiolabeled fatty acid uptake assays, lipidomics, histology, metabolic phenotyping The Journal of biological chemistry High 21808061
2012 FATP1 and ACSVL4/FATP4 both localize to the ER (not plasma membrane) in 3T3-L1 adipocytes as confirmed by confocal microscopy and subcellular fractionation; stable overexpression increases acyl-CoA synthetase activity and fatty acid uptake. Insulin increases fatty acid uptake without changing the ER localization of FATP1 or FATP4. Retroviral stable overexpression, confocal microscopy, subcellular fractionation, acyl-CoA synthetase activity assays, fatty acid uptake assays, insulin treatment PloS one Medium 23024797
2013 FATP4 was identified as a negative regulator of RPE65 isomerase activity; FATP4 inhibits synthesis of 11-cis-retinol (11cROL) in the visual cycle through two mechanisms: (1) competition with RPE65 for substrate, and (2) production of lignoceroyl (C24:0)-CoA which inhibits 11cROL synthesis. FATP4-deficient RPE shows significantly higher RPE65 isomerase activity, faster 11-cis-retinaldehyde regeneration, and faster rod light sensitivity recovery, but increased accumulation of cytotoxic all-trans retinaldehyde and hypersusceptibility to light-induced photoreceptor degeneration. Expression screening of bovine RPE cDNA library, FATP4-deficient mice, isomerase activity assays, retinoid analysis, electrophysiology The Journal of neuroscience High 23407971
2012 FATP4 and ichthyin (NIPAL4 product) show close proximity interaction in the upper stratum granulosum of normal epidermis by proximity ligation assay. In IPS skin lacking FATP4, ichthyin expression is reduced; conversely, NIPAL4-mutant skin shows increased FATP4 staining, suggesting mutual interdependence in epidermal lipid processing. Immunofluorescence, proximity ligation assay (PLA) in human skin biopsies and organotypic epidermis with siRNA silencing Journal of dermatological science Medium 23290633
2015 SLC27A4 directly interacts with ATG4B (a cysteine protease required for autophagy) in lung cancer cell lines, as shown by co-immunoprecipitation and GST-pull down assays; SLC27A4 stabilizes ATG4B protein and maintains its intracellular concentration, promoting rapid ATG4B-mediated autophagy in response to chemotherapy stress. Tandem affinity purification/mass spectrometry (TAP/MS), co-immunoprecipitation, GST-pulldown, siRNA knockdown with autophagy and drug sensitivity readouts Tumour biology Medium 26662804
2019 ETEC K88 challenge reduces FATP4 protein expression in intestinal epithelial cells via phosphorylation of ERK1/2 and PPARγ (ERK1/2-PPARγ pathway), impairing FATP4-dependent long-chain fatty acid (LCFA) uptake; gene knockdown and overexpression confirmed FATP4 as the responsible transporter for LCFA (C16:0) but not medium-chain fatty acid (C12:0) uptake in IPEC-J2 cells. In vivo piglet model, polarized IPEC-J2 cell model, FATP4 knockdown and overexpression, ERK1/2 inhibitor (U0126) and PPARγ antagonist (T0070907), BODIPY-labeled fatty acid uptake assays Frontiers in physiology Medium 31281267
2020 FATP4 exhibits acyl-CoA synthetase activity toward ω-hydroxy fatty acids, intermediates in the acylceramide synthetic pathway; Fatp4 knockout mice show severely reduced total acylceramide levels (~10% of wild type), decreased and shortened saturated non-acylated ceramides, and reduced ELOVL1 elongase expression, establishing FATP4 as the acyl-CoA synthetase responsible for acylceramide synthesis required for epidermal permeability barrier formation. In vitro ACS activity assay with ω-hydroxy fatty acid substrate, Fatp4 KO mice lipidomics, siRNA knockdown in human keratinocytes, ELOVL1 expression analysis Proceedings of the National Academy of Sciences of the United States of America High 31974308
2021 FATP4 inactivation in macrophages (THP-1 knockdown and bone marrow-derived macrophages from Fatp4M-/- mice) causes a metabolic shift towards triacylglycerides, decreases ceramide levels, and attenuates M1 activation- or ER stress-induced pro-inflammatory cytokine release (IL-8, TNF-α, IL-12). FATP4 deficiency specifically attenuates tunicamycin-induced activation of IRE1α but not other unfolded protein response pathways. siRNA knockdown in THP-1-derived macrophages, macrophage-specific Fatp4-KO mice (BMDMs), lipidomics, cytokine measurements, UPR pathway analysis The Biochemical journal Medium 33900381
2023 PLIN5 interacts with FATP4 at lipid droplet-mitochondria contact sites; the C-terminal domains of PLIN5 and FATP4 constitute a minimal protein interaction sufficient to induce organelle contacts. Phosphorylation of PLIN5 upon starvation promotes LD-to-mitochondria fatty acid trafficking and β-oxidation, requiring an intact PLIN5 mitochondrial tethering domain and functional FATP4 on mitochondria for conversion of fatty acids to acyl-CoAs. Co-immunoprecipitation, domain mapping (C-terminal interaction), organelle contact site imaging, starvation/phosphorylation experiments in human and murine myoblasts, β-oxidation assays Developmental cell High 37290445
2023 SLC27A4 overexpression promotes selective uptake of mono-unsaturated fatty acids (MUFAs) in HCC cells, leading to elevated MUFA-containing phosphatidylcholine and phosphatidylethanolamine, which confers resistance to lipid peroxidation and ferroptosis; SLC27A4 silencing sensitizes HCC cells to sorafenib both in vitro and in vivo. Lipidomic analysis, SLC27A4 overexpression and siRNA knockdown, ferroptosis assays, xenograft mouse model Free radical biology & medicine Medium 36924851
2024 Hepatocyte-specific SLC27A4 deletion ameliorates NAFLD in mice; SLC27A4 overexpression increases hepatic phosphatidylcholine (PC) accumulation, which activates pregnane X receptor (PXR) signaling and further induces SLC27A4 expression forming a feedforward loop. PXR overexpression reverses the protective effect of Slc27a4 deletion, while PXR deficiency reduces the effect of Slc27a4 overexpression on NAFLD. AAV-mediated liver overexpression, hepatocyte-specific Cre-lox KO, lipidomics, RNA-seq, PXR genetic epistasis (overexpression and KO crosses), biochemical and histological analysis Metabolism: clinical and experimental High 39489412
2024 Enterocyte-specific Fatp4 knockout mice show a metabolic shift from very long-chain to long-chain fatty acids and from polar lipids (ceramides, sphingomyelin, phosphatidylcholine) to neutral lipids predominantly in the ileum, resulting in elevated plasma triglycerides, chylomicrons, and lipoproteins after fat loading or high-fat feeding, establishing FATP4's role in controlling intestinal lipid processing and blood lipid levels. Villin-Cre enterocyte-specific Fatp4 KO mice, lipidomics of intestinal segments, plasma lipid and lipoprotein measurements after oral fat loading and chronic HFHC feeding American journal of physiology. Gastrointestinal and liver physiology Medium 38915276
2025 sEV-NAMPT activates NF-κB through TLR4, leading to elevated SLC27A4 expression; SLC27A4 then increases intracellular triacylglycerol (TG) and dihydroxyacetone phosphate (DHAP) levels, linking lipid metabolism to glycolysis by facilitating conversion of glycerol-3-phosphate to DHAP via lipolysis of TG. Mass spectrometry protein analysis of HCC-derived sEV, NF-κB signaling assays, lipidomic and metabolomic analysis, SLC27A4 knockdown/overexpression, hepatic lipase activity assays Journal of extracellular vesicles Medium 40237223

Source papers

Stage 0 corpus · 49 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. Journal of cell science 183 17062637
2003 Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. The Journal of cell biology 154 12821645
2009 Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on fatty acid esterification and oxidation in rat skeletal muscle. The Journal of biological chemistry 146 19380575
2001 Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase. Gene 119 11404000
2005 Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice. The Journal of biological chemistry 114 15653672
2023 PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport. Developmental cell 112 37290445
2011 Overexpression of CD36 and acyl-CoA synthetases FATP2, FATP4 and ACSL1 increases fatty acid uptake in human hepatoma cells. International journal of medical sciences 103 22022213
2012 Overexpressed FATP1, ACSVL4/FATP4 and ACSL1 increase the cellular fatty acid uptake of 3T3-L1 adipocytes but are localized on intracellular membranes. PloS one 71 23024797
2020 Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid ω-O-acylceramide. Proceedings of the National Academy of Sciences of the United States of America 56 31974308
2007 Keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in Slc27a4/Fatp4 mutant mice. The Journal of biological chemistry 47 17401141
2011 Adipocyte-specific inactivation of Acyl-CoA synthetase fatty acid transport protein 4 (Fatp4) in mice causes adipose hypertrophy and alterations in metabolism of complex lipids under high fat diet. The Journal of biological chemistry 44 21808061
2018 Solute Carrier Family 27 Member 4 (SLC27A4) Enhances Cell Growth, Migration, and Invasion in Breast Cancer Cells. International journal of molecular sciences 40 30388870
2006 Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4. Bioorganic & medicinal chemistry letters 39 16644217
2023 SLC27A4-mediated selective uptake of mono-unsaturated fatty acids promotes ferroptosis defense in hepatocellular carcinoma. Free radical biology & medicine 38 36924851
2006 Expression pattern of fatty acid transport protein-1 (FATP-1), FATP-4 and heart-fatty acid binding protein (H-FABP) genes in human term placenta. Early human development 36 16574350
2013 Fatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase. The Journal of neuroscience : the official journal of the Society for Neuroscience 34 23407971
2015 SLC27A4 regulate ATG4B activity and control reactions to chemotherapeutics-induced autophagy in human lung cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 33 26662804
2005 Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency. The Journal of investigative dermatology 33 16354193
2011 FATP4 missense and nonsense mutations cause similar features in Ichthyosis Prematurity Syndrome. BMC research notes 32 21450060
2011 FATP4 contributes as an enzyme to the basal and insulin-mediated fatty acid uptake of C₂C₁₂ muscle cells. American journal of physiology. Endocrinology and metabolism 30 21750264
2020 LncRNA HOXD-AS1 promotes the metastasis of human hepatocellular carcinoma via modulating miR-326/SLC27A4. Cancer cell international 23 32425696
2015 A Novel SLC27A4 Splice Acceptor Site Mutation in Great Danes with Ichthyosis. PloS one 22 26506231
2022 Stearic Acid Activates the PI3K-mTOR-4EBP1/S6K and mTOR-SREBP-1 Signaling Axes through FATP4-CDK1 To Promote Milk Synthesis in Primary Bovine Mammary Epithelial Cells. Journal of agricultural and food chemistry 21 35333520
2015 Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism. Scientific reports 19 26548558
2012 Interactions between FATP4 and ichthyin in epidermal lipid processing may provide clues to the pathogenesis of autosomal recessive congenital ichthyosis. Journal of dermatological science 17 23290633
2019 Antimicrobial peptide KR-32 alleviates Escherichia coli K88-induced fatty acid malabsorption by improving expression of fatty acid transporter protein 4 (FATP4)1. Journal of animal science 16 30958881
2010 Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling. Developmental biology 16 20513444
2008 Genetic polymorphisms and preliminary association analysis with production traits of the porcine SLC27A4 gene. Molecular biology reports 15 18696256
2023 ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans. Nature communications 14 38001113
2022 Vitamin D and Swimming Exercise Prevent Obesity in Rats under a High-Fat Diet via Targeting FATP4 and TLR4 in the Liver and Adipose Tissue. International journal of environmental research and public health 12 36360622
2012 A spontaneous Fatp4/Scl27a4 splice site mutation in a new murine model for congenital ichthyosis. PloS one 12 23226340
2019 Enterotoxigenic Escherichia coli Interferes FATP4-Dependent Long-Chain Fatty Acid Uptake of Intestinal Epithelial Enterocytes via Phosphorylation of ERK1/2-PPARγ Pathway. Frontiers in physiology 11 31281267
2024 Hepatocyte-specific SLC27A4 deletion ameliorates nonalcoholic fatty liver disease in mice via suppression of phosphatidylcholine-mediated PXR activation. Metabolism: clinical and experimental 10 39489412
2015 Ichthyosis prematurity syndrome caused by a novel missense mutation in FATP4 gene-a case report from India. Clinical case reports 10 26783444
2023 Reduced Expression of Very-Long-Chain Acyl-CoA Synthetases SLC27A4 and SLC27A6 in the Glioblastoma Tumor Compared to the Peritumoral Area. Brain sciences 9 37239243
2020 Methionine- and Choline-Deficient Diet Enhances Adipose Lipolysis and Leptin Release in aP2-Cre Fatp4-Knockout Mice. Molecular nutrition & food research 8 32991778
2020 Ichthyosis prematurity syndrome in two Omani siblings, caused by homozygous c.1A > G mutation in the FATP4 gene. International journal of dermatology 8 33319372
2018 Sex-specific Alterations in Serology and the Expression of Liver FATP4 Protein in Offspring Exposed to High-Fat Diet during Pregnancy and/or Lactation. Lipids 8 29701266
2015 Identification of novel FATP4 mutations in a Japanese patient with ichthyosis prematurity syndrome. Human genome variation 7 27081519
2021 FATP4 inactivation in cultured macrophages attenuates M1- and ER stress-induced cytokine release via a metabolic shift towards triacylglycerides. The Biochemical journal 6 33900381
2024 DHA Improves neurodevelopmental abnormalities in offspring of gestational diabetes mellitus patients via the PPAR-γ/FATP4 pathway. Biochemical pharmacology 5 39716642
2005 [The expression and the significance of L-FABP and FATP4 in the development of nonalcoholic fatty liver disease in rats]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 5 16248953
2025 Small Extracellular Vesicle-Derived Nicotinamide Phosphoribosyltransferase (NAMPT) Induces Acyl-Coenzyme A Synthetase SLC27A4-Mediated Glycolysis to Promote Hepatocellular Carcinoma. Journal of extracellular vesicles 4 40237223
2023 FATP4 deletion in liver cells induces elevation of extracellular lipids via metabolic channeling towards triglycerides and lipolysis. Biochemical and biophysical research communications 4 37931418
2012 Ontogenic expression pattern and genetic polymorphisms of the fatty acid transport protein 4 (FATP4) gene in Chinese chicken populations. International journal of molecular sciences 4 22837665
2024 Enterocyte-specific FATP4 deficiency elevates blood lipids via a shift from polar to neutral lipids in distal intestine. American journal of physiology. Gastrointestinal and liver physiology 1 38915276
2026 Decreased fatty acid transporter FATP4 is a potential contributor to impaired fat utilization in aging mice. Biogerontology 0 41642371
2026 FATP4 Switches Cellular Lipid Utilization via the PI3K-AKT Pathway in Goat Preadipocytes. Animals : an open access journal from MDPI 0 42071899
2025 Ichthyosis Prematurity Syndrome Caused by a Novel Homozygous SLC27A4 Mutation in Two Emirati Siblings. Cureus 0 41409931

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