Affinage

SLC25A37

Mitoferrin-1 · UniProt Q9NYZ2

Length
338 aa
Mass
37.3 kDa
Annotated
2026-04-28
87 papers in source corpus 23 papers cited in narrative 24 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLC25A37 (mitoferrin-1/Mfrn1) is a mitochondrial inner membrane iron transporter that imports free Fe(II) into the mitochondrial matrix to support heme biosynthesis, iron–sulfur cluster assembly, and oxidative phosphorylation. It transports Fe(II) with micromolar affinity and forms an oligomeric complex with Abcb10 and ferrochelatase that couples iron import directly to heme synthesis; Abcb10 stabilizes Mfrn1 protein via its N-terminal domain (PMID:29305420, PMID:19805291, PMID:20427704). Transcription is driven by GATA-1 through a hierarchically organized super-enhancer in erythroid cells, and protein turnover is regulated by PINK1–PARK2-mediated mitophagy (PMID:21248200, PMID:26766440, PMID:30100261). Loss of Mfrn1 causes embryonic lethality and severe anemia in mice, erythroid G2/M cell cycle arrest in zebrafish, and protoporphyria with liver cirrhosis in hepatocyte-specific knockouts, while excessive Mfrn1 activity promotes mitochondrial iron overload and ferroptosis in multiple tissues (PMID:21310927, PMID:40601908, PMID:37741044).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2001 Low

    Initial cloning established SLC25A37 as a member of the mitochondrial carrier family with six transmembrane domains and three energy-transfer signature motifs, but its transported substrate was unknown.

    Evidence cDNA cloning, Northern blot, and sequence homology to yeast MRS3/MRS4 in mouse tissues

    PMID:11845285

    Open questions at the time
    • No transport substrate identified
    • No functional assay performed
    • Expression data limited to Northern blot
  2. 2006 High

    Positional cloning of the zebrafish frascati mutant identified SLC25A37 as the principal mitochondrial iron importer required for heme biosynthesis, resolving the long-standing question of how iron enters mitochondria for erythropoiesis.

    Evidence Positional cloning, 55Fe incorporation in Mfrn1-null murine erythroblasts, cross-species complementation in zebrafish and yeast

    PMID:16511496

    Open questions at the time
    • Transport mechanism and substrate specificity not biochemically defined
    • Interacting partners unknown
    • Role in non-erythroid cells not established
  3. 2009 High

    Discovery that Abcb10 physically binds and stabilizes Mfrn1 revealed a post-translational regulatory mechanism controlling the abundance of the iron importer in erythroid mitochondria.

    Evidence Affinity purification/MS, reciprocal co-IP, protein half-life measurement, domain mapping in MEL and COS7 cells

    PMID:19805291

    Open questions at the time
    • Whether Abcb10 ATPase activity is required for stabilization unknown
    • Role of ferrochelatase in the complex not yet tested
  4. 2010 High

    Identification of ferrochelatase as a third subunit of the Mfrn1–Abcb10 complex demonstrated that iron import is physically coupled to the terminal step of heme synthesis, explaining how mitochondria coordinate iron delivery with porphyrin metallation.

    Evidence FLAG affinity purification/MS and reciprocal co-IP with endogenous proteins in MEL and HEK293 cells

    PMID:20427704

    Open questions at the time
    • Stoichiometry and structural architecture of the ternary complex undefined
    • Whether iron–sulfur cluster biogenesis uses the same complex unknown
  5. 2011 High

    Conditional knockout studies in mice established that Mfrn1 is essential for organismal viability, adult erythropoiesis, and hepatic heme synthesis, and that its loss in hepatocytes under porphyrin stress causes protoporphyria and cirrhosis.

    Evidence Total and tissue-specific Cre-mediated Mfrn1 knockout mice with biochemical and histological phenotyping

    PMID:21310927

    Open questions at the time
    • Relative contribution of Mfrn1 vs. Mfrn2 in non-erythroid tissues not resolved
    • Human disease association not established
  6. 2011 High

    ChIP and in vivo reporter assays showed that GATA-1 directly activates Mfrn1 transcription through at least two essential GATA-binding elements within cis-regulatory modules, and that a GATA-2 to GATA-1 switch governs Mfrn1 induction during erythroid maturation.

    Evidence Genome-wide ChIP, zebrafish transgenesis with CRM reporters, morpholino knockdown, GATA-element mutagenesis

    PMID:21248200

    Open questions at the time
    • Epigenetic regulation beyond GATA occupancy not addressed
    • Super-enhancer architecture not yet mapped
  7. 2014 High

    Genetic epistasis between Mfrn1 and IRP1 revealed a safety mechanism: when Mfrn1 is reduced, IRP1 represses ALAS2 translation via its 5′-IRE to prevent toxic protoporphyrin accumulation, placing Mfrn1 in a coordinated iron–heme homeostatic circuit.

    Evidence Mfrn1/Irp1 double-mutant mice, protoporphyrin measurements, IRE mutagenesis, ectopic ALAS2 expression

    PMID:24509859

    Open questions at the time
    • Whether IRP2 provides parallel regulation not tested
    • Mechanism applies to erythroid cells; generalizability unknown
  8. 2016 Medium

    CRISPR/Cas9 editing of the SLC25A37 super-enhancer revealed a functional hierarchy among constituent enhancers, including elements with opposing transcriptional activities, refining the model of how erythroid transcription of the iron importer is fine-tuned.

    Evidence CRISPR/Cas9 in situ enhancer deletion, chromatin profiling, GATA occupancy ChIP

    PMID:26766440

    Open questions at the time
    • Mechanism of opposing enhancer activities not defined
    • Whether super-enhancer architecture is conserved across species not shown
  9. 2018 High

    Biochemical reconstitution demonstrated that Mfrn1 transports free Fe(II) with micromolar affinity and can also transport other divalent transition metals (Mn, Co, Cu, Zn), while mutagenesis identified critical metal-coordinating residues — resolving the substrate specificity and transport mechanism.

    Evidence Recombinant protein reconstituted into liposomes, ITC binding, iron transport assays, extensive site-directed mutagenesis

    PMID:29305420

    Open questions at the time
    • No high-resolution structure available
    • Transport stoichiometry and counter-ion not defined
    • Whether physiological selectivity differs from in vitro selectivity unknown
  10. 2018 High

    Demonstration that PINK1–PARK2-mediated mitophagy degrades SLC25A37 established a post-translational turnover mechanism and linked mitochondrial iron homeostasis to Parkinson's disease genes and pancreatic tumorigenesis via HIF1A and AIM2 inflammasome activation.

    Evidence Pink1/Park2 knockout mice with Kras mutation, western blot, genetic rescue, iron chelation, Hif1a/Aim2 depletion

    PMID:30100261

    Open questions at the time
    • Whether PINK1–PARK2 directly ubiquitylates SLC25A37 or acts indirectly through mitophagy not resolved
    • Relevance to neuronal iron metabolism not tested
  11. 2015 Medium

    Double depletion of Mfrn1 and Mfrn2 in preadipocytes showed that mitoferrin-mediated iron import is required for iron–sulfur protein biogenesis, mitochondrial respiration, and adipogenic differentiation, extending the functional scope beyond erythropoiesis.

    Evidence RNAi double knockdown in 3T3-L1 cells, mitochondrial iron measurement, Seahorse respirometry, adipogenesis and insulin signaling assays

    PMID:26118715

    Open questions at the time
    • Mfrn1-specific vs. Mfrn2-specific contributions not separated
    • Rescue experiment not performed
  12. 2020 High

    Hepatocyte-specific double knockout of Mfrn1 and Mfrn2 proved that mitoferrin-dependent iron import is essential for liver regeneration and general cell proliferation, with overexpression of either paralog rescuing the defect.

    Evidence Conditional double KO mice, mitochondrial iron quantification, OXPHOS protein measurement, proliferation assay with overexpression rescue

    PMID:32518166

    Open questions at the time
    • Whether Mfrn1 alone is sufficient for proliferation in all tissues not resolved
    • Downstream iron-requiring processes that limit proliferation not identified
  13. 2022 High

    Combinatorial CRISPR screening uncovered a synthetic lethal interaction between SLC25A37 and the glutathione transporter SLC25A39, showing that mitochondrial iron and glutathione import jointly sustain OXPHOS — a genetic buffering relationship linking redox and iron homeostasis.

    Evidence Dual CRISPR knockout screen across metabolic states, mitochondrial metabolite profiling, organelle transport assays

    PMID:35513392

    Open questions at the time
    • Mechanism by which glutathione compensates for iron deficiency not defined
    • Whether interaction is context-dependent (e.g., erythroid vs. non-erythroid) unknown
  14. 2023 Medium

    Studies in hepatocytes and neurons revealed that Mfrn1 abundance directly tunes ferroptosis susceptibility and mitochondrial bioenergetics: overexpression promotes ferroptosis via mitochondrial iron overload, while CREB-driven induction in neurons boosts bioenergetics after synaptic activity.

    Evidence Mfrn1 KD/OE in HepG2, ferroptosis assays, mitochondrial Fe2+ measurement; neuronal activity induction, Mfrn1 KD, iron chelation, CREB ChIP

    PMID:36674431 PMID:37741044

    Open questions at the time
    • Whether CREB-mediated induction occurs in non-neuronal contexts untested
    • Sex-dimorphic regulation mechanism not fully elucidated
  15. 2024 High

    DACH1 was shown to promote p53 phosphorylation at Ser392 and p53 translocation to mitochondria where p53 binds SLC25A37 to enhance iron uptake, establishing a direct protein–protein interaction between p53 and the transporter that drives ferroptosis in hepatic stellate cells.

    Evidence Co-IP, GST pulldown, p53 Ser392 mutagenesis, subcellular fractionation, mitochondrial iron measurement, mouse hepatic fibrosis model

    PMID:38437058

    Open questions at the time
    • Structural basis for p53–SLC25A37 interaction unknown
    • Whether p53 directly modulates transport activity or merely stabilizes the protein not distinguished
  16. 2024 Medium

    Comparison of Mfrn1 and SFXN3 knockouts in non-erythroid fibroblasts confirmed Mfrn1 as the dominant mitochondrial iron importer even outside the erythroid lineage.

    Evidence MFRN1 vs. SFXN3 KO in mouse embryonic fibroblasts, mitochondrial catalytic Fe(II) and heme synthesis measurement

    PMID:38599240

    Open questions at the time
    • Whether SFXN3 contributes under specific metabolic conditions not excluded
    • Role in primary human non-erythroid cells not verified
  17. 2025 High

    Mfrn1 deficiency causes erythroid-specific G2/M cell cycle arrest in zebrafish, rescuable by iron supplementation, revealing that mitochondrial iron import is required for a cell cycle checkpoint during terminal erythroid differentiation.

    Evidence Zebrafish mfrn1 mutants, iron rescue, scRNA-seq, FACS with erythroid reporters, cell cycle analysis

    PMID:40601908

    Open questions at the time
    • Identity of the iron-dependent G2/M target not determined
    • Whether this checkpoint operates in mammalian erythropoiesis not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • A high-resolution structure of Mfrn1 — alone and in complex with Abcb10 and ferrochelatase — is needed to explain transport mechanism, substrate selectivity, and how p53 binding enhances iron uptake; the molecular identity of the iron-dependent G2/M checkpoint target in erythroid cells remains unknown.
  • No structural model of Mfrn1 or the ternary complex exists
  • Iron-dependent cell cycle checkpoint target unidentified
  • Whether PINK1–PARK2 directly ubiquitylates SLC25A37 or acts via bulk mitophagy is unresolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 2
Localization
GO:0005739 mitochondrion 4
Pathway
R-HSA-1430728 Metabolism 4 R-HSA-5357801 Programmed Cell Death 3 R-HSA-1640170 Cell Cycle 2 R-HSA-9612973 Autophagy 1
Partners
ABCB10FECHIRP1SLC25A39TP53
Complex memberships
Mfrn1–Abcb10–ferrochelatase complex

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 SLC25A37 (mitoferrin/Mfrn1) functions as the principal mitochondrial iron importer essential for heme biosynthesis in vertebrate erythroblasts; loss-of-function in zebrafish (frascati mutant) causes hypochromic anemia and erythroid maturation arrest with severely impaired 55Fe incorporation into heme, and murine Mfrn1 rescues the zebrafish defect while zebrafish mfrn1 complements yeast mrs3/mrs4 mutants. Positional cloning, 55Fe incorporation assay in Mfrn1-null murine erythroblasts derived from embryonic stem cells, cross-species complementation (zebrafish rescue and yeast complementation) Nature High 16511496
2009 Mfrn1 (SLC25A37) physically interacts with Abcb10 (a mitochondrial inner membrane ABC transporter) at its N-terminal domain; Abcb10 stabilizes Mfrn1 protein and enhances Mfrn1-dependent mitochondrial iron importation in erythroid cells. In vivo epitope-tagging affinity purification and mass spectrometry, co-immunoprecipitation, protein half-life measurement, cotransfection in COS7 and MEL cells, domain mapping Proceedings of the National Academy of Sciences of the United States of America High 19805291
2010 Ferrochelatase (Fech), the terminal heme synthesis enzyme, physically interacts with Mfrn1 and Abcb10 to form an oligomeric complex in erythroid mitochondria, coupling mitochondrial iron importation to heme biosynthesis. Affinity purification and mass spectrometry from stable FLAG-tagged MEL cell clones, co-immunoprecipitation/Western blot with endogenous proteins in MEL cells and heterologous HEK293 cells Blood High 20427704
2011 Total deletion of Mfrn1 in mouse embryos causes embryonic lethality; selective deletion in adult hematopoietic tissues causes severe anemia due to erythroblast formation deficit; deletion in hepatocytes under conditions of increased porphyrin synthesis leads to protoporphyria, cholestasis, and bridging cirrhosis due to inability to convert protoporphyrin IX to heme. Conditional and total Mfrn1 knockout mouse models, hematopoietic tissue-specific and hepatocyte-specific Cre-mediated deletion, biochemical and histological phenotyping Blood High 21310927
2011 GATA-1 directly regulates Mfrn1 (SLC25A37) transcription during erythroid maturation through cis-regulatory modules (CRMs) containing GATA-binding elements; mutagenesis of individual GATA-1 binding elements showed at least two of three are required for GATA-mediated Mfrn1 transcription. ChIP assays demonstrate switching from GATA-2 to GATA-1 at these elements during erythroid maturation. Genome-wide ChIP for GATA-1, zebrafish transgenesis with CRM-reporter constructs, morpholino knockdown, GATA-binding element mutagenesis, ChIP assays in differentiating cells Molecular and cellular biology High 21248200
2014 Iron regulatory protein-1 (IRP1) protects against protoporphyrin accumulation in Mfrn1-deficient erythroid cells by binding the 5'-IRE of alas2 mRNA to inhibit its translation; Mfrn1/Irp1 double-mutant erythroid cells show significantly increased protoporphyrin levels, and ectopic alas2 with a mutant IRE phenocopies IRP1 deficiency. Gene trap mouse model (Mfrn1+/gt;Irp1-/-), protoporphyrin measurements, IRE mutagenesis, ectopic alas2 expression, epistasis analysis The Journal of biological chemistry High 24509859
2014 SF3B1 mutations in myelodysplastic syndrome with ring sideroblasts lead to higher expression of a specific retained-intron isoform of SLC25A37, contributing to mitochondrial iron overload without changing iron valence (Fe2+ retained in both mutant and wild-type). RNA sequencing, RT-PCR, transmission electron microscopy/spectroscopy, flow cytometry for iron measurement in patient samples Leukemia Medium 24854990
2018 Mfrn1 (SLC25A37) transports Fe(II) with micromolar affinity and can also transport Mn(II), Co(II), Cu, and Zn but discriminates against Ni and alkali divalent ions; it transports free iron rather than chelated iron complexes. Multiple residues with side chains capable of coordinating first-row transition metals are critical for metal binding and/or transport activity. Recombinant protein purification under non-denaturing conditions, isothermal titration calorimetry, in vitro reconstitution into defined liposomes, iron transport assay, extensive site-directed mutagenesis The Journal of biological chemistry High 29305420
2018 PINK1-PARK2 pathway-mediated autophagic degradation of SLC25A37 (and SLC25A28) suppresses mitochondrial iron accumulation; depletion of Pink1 and Park2 leads to increased SLC25A37 levels, mitochondrial iron accumulation, HIF1A-dependent Warburg effect, and AIM2-dependent inflammasome activation promoting pancreatic tumorigenesis. Spontaneous pancreatic cancer mouse models (Pink1/Park2 knockout with mutant Kras), western blot, genetic rescue, pharmacological iron chelation, genetic depletion of Hif1a and Aim2 Developmental cell High 30100261
2016 SLC25A37 expression in erythroid cells is controlled by a super-enhancer; CRISPR/Cas9-mediated genomic editing of constituent enhancers within this super-enhancer revealed functional hierarchy among elements including some with opposing activities that cooperate to coordinate transcription. CRISPR/Cas9 in situ enhancer editing, chromatin profiling, GATA transcription factor occupancy ChIP Developmental cell Medium 26766440
2020 Both Mfrn1 (SLC25A37) and Mfrn2 are required for liver regeneration and cell proliferation; double knockout of Mfrn1 and Mfrn2 in hepatocytes resulted in 40% reduction in mitochondrial iron and reduced OXPHOS proteins; bone marrow-derived macrophages or skin fibroblasts lacking both mitoferrins cannot proliferate, and overexpression of Mfrn1-GFP or Mfrn2-GFP rescues this defect. Hepatocyte-specific and hematopoietic-specific conditional knockout mice, mitochondrial iron measurement, OXPHOS protein quantification, proliferation assay, overexpression rescue in primary cells The Journal of biological chemistry High 32518166
2022 SLC25A37 (A37) and SLC25A39 have a genetic buffering (synthetic lethal) interaction; A37-mediated mitochondrial iron uptake and A39-mediated mitochondrial glutathione import jointly support mitochondrial OXPHOS, as revealed by combinatorial CRISPR screening. Pooled dual CRISPR knockout screening across four metabolic states, mitochondrial metabolite profiling, organelle transport assays, structure-guided mutagenesis of SLC25A39 Nature communications High 35513392
2021 ENO1 suppresses Mfrn1 expression by recruiting CNOT6 to accelerate IRP1 mRNA decay, thereby reducing mitochondrial iron import; knockdown of IRP1 reduces Mfrn1 expression and suppresses mitochondrial iron-induced ferroptosis in HCC cells, placing Mfrn1 downstream of the ENO1-IRP1 axis. RNA-binding protein assay (ENO1 as RBP), mRNA stability assay, IRP1 knockdown, Mfrn1 expression measurement, in vitro and in vivo ferroptosis assays Nature cancer High 35121990
2023 Synaptic activity transcriptionally induces Mfrn1 expression via CREB, leading to enhanced mitochondrial iron uptake that boosts mitochondrial bioenergetics beyond the duration of synaptic activity; iron chelation or Mfrn1 knockdown blocks this activity-mediated bioenergetics increase in neurons. Neuronal activity induction assay, Mfrn1 knockdown (RNAi), iron chelation, mitochondrial bioenergetics measurement, CREB reporter and ChIP International journal of molecular sciences Medium 36674431
2023 Mfrn1 (SLC25A37) knockdown decreases ferroptosis and mitochondrial iron accumulation in hepatocytes, while Mfrn1 overexpression exacerbates ferroptosis; lower Mfrn1 expression in female hepatocytes (compared to male) accounts in part for sexual dimorphism in ferroptosis susceptibility. Mfrn1 knockdown in HepG2 cells, ferroptosis induction assays, mitochondrial Fe2+ measurement, sex hormone manipulation (ovariectomy) Redox biology Medium 37741044
2024 DACH1 promotes p53 phosphorylation at serine 392 and mitochondrial translocation of p53, which then binds SLC25A37 to enhance its iron uptake capacity, causing mitochondrial iron overload and ferroptosis; mutation of p53 Ser392 prevents DACH1-p53 interaction and SLC25A37-mediated ferroptosis. Knockdown of SLC25A37 impairs p53-mediated mitochondrial iron overload and ferroptosis in hepatic stellate cells. CRISPR-Cas9 DACH1 knockout, immunoprecipitation, GST pulldown, p53 Ser392 mutagenesis, subcellular fractionation, mitochondrial iron measurement, mouse hepatic fibrosis model with HSC-specific knockdowns Hepatology communications High 38437058
2023 Mfrn1 overexpression in glioma cells increases mitochondrial iron levels, enhances cell proliferation and anchorage-independent growth, decreases mouse survival in orthotopic glioma, and upregulates glutathione, protecting glioma cells from 4-hydroxynonenal-induced protein damage. Mfrn1 overexpression in glioma cell lines, mitochondrial iron measurement, proliferation and anchorage-independent growth assays, orthotopic mouse model, glutathione measurement Antioxidants (Basel, Switzerland) Medium 36829908
2025 Mitochondrial iron transport via Mfrn1 is essential for erythroid cell cycle progression; mfrn1-deficient zebrafish embryos show erythroid cell cycle arrest at G2/M with enlarged nuclei suggesting a mitotic defect; iron supplementation rescues the cell cycle defect, and the proliferative defect is specific to terminally differentiating erythroid cells. Zebrafish mfrn1 mutants, iron supplementation rescue, single-cell RNA sequencing, FACS with erythroid reporter lines (cd41, gata1), cell cycle analysis Blood advances High 40601908
2015 Depletion of Mfrn1 and Mfrn2 in 3T3-L1 preadipocytes impairs biosynthesis of iron-sulfur proteins due to reduced mitochondrial iron content, decreases mitochondrial oxygen consumption rate and ATP levels, reduces expression of adipogenic genes, impairs lipid production during adipogenic differentiation, and decreases insulin-induced glucose uptake and Akt phosphorylation. Double knockdown of Mfrn1 and Mfrn2 by RNAi in 3T3-L1 cells, mitochondrial iron measurement, oxygen consumption rate (Seahorse), ATP assay, adipogenesis assay, insulin signaling assay Free radical research Medium 26118715
2020 Knockdown of SLC25A37 in osteosarcoma cells decreases ROS production, implicating Mfrn1-mediated mitochondrial iron import in iron-induced ROS generation that promotes the Warburg effect and carcinogenesis. shRNA stable knockdown of SLC25A37, ROS measurement (DCFH-DA), Seahorse respirometry, cell proliferation and carcinogenesis assays Cancer cell international Low 32831652
2025 SLC25A37 (Mfrn1) is required for neutrophil oxidative phosphorylation, NET formation, and type I IFN production downstream of TLR9; CRISPR targeting of SLC25A37 in a neutrophil differentiation platform disrupted this metabolic-immune circuit. Targeted CRISPR-Cas9 screen in CD34+-derived neutrophils, NET formation assay, IFN production measurement, TLR9 stimulation, OXPHOS measurement bioRxivpreprint Low
2024 MFRN1 knockout in mouse embryonic fibroblasts causes more intense mitochondrial Fe(II) deficiency than SFXN3 knockout, confirming Mfrn1 as the dominant mitochondrial iron importer in non-erythroid cells; Mfrn1 KO also results in insufficient mitochondrial heme synthesis under iron overload. MFRN1 knockout in mouse embryonic fibroblasts, mitochondrial catalytic Fe(II) measurement, heme synthesis assay, comparison with SFXN3 KO Free radical research Medium 38599240
2025 Mfrn1 knockdown in MCAO/R rat model suppresses ferroptosis, reduces mitochondrial iron accumulation and mitochondrial damage, and reduces AIS-related injury; overexpression of Mfrn1 exacerbates all these effects, establishing Mfrn1 as a promoter of mitochondrial iron overload and ferroptotic damage in acute ischemic stroke. RNAi knockdown and AAV9-mediated overexpression in vitro (OGD/R) and in vivo (MCAO/R rat), mitochondrial iron measurement, ferroptosis markers, RNA sequencing International immunopharmacology Medium 40199135
2001 The murine SLC25A37 (Mscp) gene encodes a protein with six transmembrane domains and three mitochondrial energy-transfer protein signature motifs characteristic of the mitochondrial carrier family, sharing 50% identity with C. elegans T26089 and ~40% with yeast MRS3/MRS4; its mRNA is highly expressed in spleen and rapidly decreases at 4-5 weeks of age during splenic lymphocyte maturation. cDNA cloning, Northern blot analysis, sequence homology analysis, cDNA microarray Mammalian genome : official journal of the International Mammalian Genome Society Low 11845285

Source papers

Stage 0 corpus · 87 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 Mitoferrin is essential for erythroid iron assimilation. Nature 503 16511496
2018 PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism. Developmental cell 221 30100261
2016 Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. Developmental cell 192 26766440
2009 Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proceedings of the National Academy of Sciences of the United States of America 169 19805291
2021 ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1. Nature cancer 167 35121990
2022 Pan-cancer genetic analysis of cuproptosis and copper metabolism-related gene set. Frontiers in oncology 153 36276096
2004 Human high molecular weight-melanoma-associated antigen (HMW-MAA): a melanoma cell surface chondroitin sulfate proteoglycan (MSCP) with biological and clinical significance. Critical reviews in immunology 151 15588226
2010 Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis. Blood 128 20427704
2022 P-Doped NiTe2 with Te-Vacancies in Lithium-Sulfur Batteries Prevents Shuttling and Promotes Polysulfide Conversion. Advanced materials (Deerfield Beach, Fla.) 111 35019192
2008 Effects of cyclic mechanical stretching on the mRNA expression of tendon/ligament-related and osteoblast-specific genes in human mesenchymal stem cells. Connective tissue research 94 18293173
2021 Liraglutide Alleviates Cognitive Deficit in db/db Mice: Involvement in Oxidative Stress, Iron Overload, and Ferroptosis. Neurochemical research 88 34480710
2011 Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria. Blood 88 21310927
2022 Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS. Nature communications 83 35513392
2021 Polysaccharides From the Roots of Millettia Speciosa Champ Modulate Gut Health and Ameliorate Cyclophosphamide-Induced Intestinal Injury and Immunosuppression. Frontiers in immunology 56 34745141
2020 The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice. The Journal of biological chemistry 54 32518166
2014 Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron. Leukemia 54 24854990
2020 Mitochondrion-mediated iron accumulation promotes carcinogenesis and Warburg effect through reactive oxygen species in osteosarcoma. Cancer cell international 48 32831652
2018 Mitochondrial quality control mediated by PINK1 and PRKN: links to iron metabolism and tumor immunity. Autophagy 46 30252570
2021 RNA m6A Demethylase ALKBH5 Protects Against Pancreatic Ductal Adenocarcinoma via Targeting Regulators of Iron Metabolism. Frontiers in cell and developmental biology 44 34733841
2014 The impact of microRNA expression on cellular proliferation. Human genetics 43 24609542
2011 Abnormal mitoferrin-1 expression in patients with erythropoietic protoporphyria. Experimental hematology 43 21627978
2009 Overexpression of Drosophila mitoferrin in l(2)mbn cells results in dysregulation of Fer1HCH expression. The Biochemical journal 41 19453295
2018 In vitro reconstitution, functional dissection, and mutational analysis of metal ion transport by mitoferrin-1. The Journal of biological chemistry 40 29305420
2014 Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria. The Journal of biological chemistry 36 24509859
2018 Antioxidant and anti-inflammatory capacities of collagen peptides from milkfish (Chanos chanos) scales. Journal of food science and technology 35 29892131
2009 Continuous occurrence of both insufficient neovascularization and elevated vascular permeability in rabbit proximal femur during inadequate repair of steroid-associated osteonecrotic lesions. Arthritis and rheumatism 35 19790047
2011 Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis. Molecular and cellular biology 32 21248200
2020 MiR-7 mediates mitochondrial impairment to trigger apoptosis and necroptosis in Rhabdomyosarcoma. Biochimica et biophysica acta. Molecular cell research 31 32810522
2023 Identification and Analysis of Neutrophil Extracellular Trap-Related Genes in Osteoarthritis by Bioinformatics and Experimental Verification. Journal of inflammation research 27 37671131
2016 Single-cell isolation by a modular single-cell pipette for RNA-sequencing. Lab on a chip 27 27841430
2014 Differential expression of genes related to mitochondrial biogenesis and bioenergetics in fatigued prostate cancer men receiving external beam radiation therapy. Journal of pain and symptom management 27 24786901
2023 Differences in hepatocellular iron metabolism underlie sexual dimorphism in hepatocyte ferroptosis. Redox biology 24 37741044
2016 Identification of SLC25A37 as a major depressive disorder risk gene. Journal of psychiatric research 23 27643475
2024 Characterizing mitochondrial features in osteoarthritis through integrative multi-omics and machine learning analysis. Frontiers in immunology 22 39026663
2015 Deregulation of genes related to iron and mitochondrial metabolism in refractory anemia with ring sideroblasts. PloS one 21 25955609
2022 Extracellular Vesicles Derived from Primed Mesenchymal Stromal Cells Loaded on Biphasic Calcium Phosphate Biomaterial Exhibit Enhanced Macrophage Polarization. Cells 19 35159282
2020 Sea Cucumber Peptides Improved the Mitochondrial Capacity of Mice: A Potential Mechanism to Enhance Gluconeogenesis and Fat Catabolism during Exercise for Improved Antifatigue Property. Oxidative medicine and cellular longevity 19 32685094
2021 TRPM8 channel inhibitor-encapsulated hydrogel as a tunable surface for bone tissue engineering. Scientific reports 18 33580126
2020 Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence. Cells 18 33023155
2024 PINK1-deficiency facilitates mitochondrial iron accumulation and colon tumorigenesis. Autophagy 17 39512202
2023 FoxO1 regulates adipose transdifferentiation and iron influx by mediating Tgfβ1 signaling pathway. Redox biology 17 37156218
2021 IL-1β primed mesenchymal stromal cells moderate hemorrhagic shock-induced organ injuries. Stem cell research & therapy 17 34353366
2015 Depletion of mitoferrins leads to mitochondrial dysfunction and impairment of adipogenic differentiation in 3T3-L1 preadipocytes. Free radical research 17 26118715
2018 Anti-cholinergics mecamylamine and scopolamine alleviate motion sickness-induced gastrointestinal symptoms through both peripheral and central actions. Neuropharmacology 14 30543811
2019 50-Hz magnetic field impairs the expression of iron-related genes in the in vitro SOD1G93A model of amyotrophic lateral sclerosis. International journal of radiation biology 13 30513241
2019 Generation and Molecular Characterization of Human Ring Sideroblasts: a Key Role of Ferrous Iron in Terminal Erythroid Differentiation and Ring Sideroblast Formation. Molecular and cellular biology 13 30670569
2024 Integrated multi-omics and artificial intelligence to explore new neutrophils clusters and potential biomarkers in sepsis with experimental validation. Frontiers in immunology 11 38868781
2023 Mitoferrin-1 Promotes Proliferation and Abrogates Protein Oxidation via the Glutathione Pathway in Glioblastoma. Antioxidants (Basel, Switzerland) 10 36829908
2021 Analysis of genetic and clinical factors associated with buprenorphine response. Drug and alcohol dependence 10 34488071
2024 The cell fate regulator DACH1 modulates ferroptosis through affecting P53/SLC25A37 signaling in fibrotic disease. Hepatology communications 9 38437058
2018 RNA expression profiling in sulfamethoxazole-treated patients with a range of in vitro lymphocyte cytotoxicity phenotypes. Pharmacology research & perspectives 8 29511567
2024 Microglia and Immune cells interactions in multiple sclerosis cognitive impairment: a postmortem study. Journal of neuroinflammation 7 39741293
2023 Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics. International journal of molecular sciences 7 36674431
2022 A role for ceruloplasmin in the control of human glioblastoma cell responses to radiation. BMC cancer 7 35918659
2019 The role of hepcidin, GDF15, and mitoferrin-1 in iron metabolism of polycythemia vera and essential thrombocytosis patients. Turkish journal of medical sciences 7 30761871
2009 Cutaneous mycobacterial spindle cell pseudotumour. BMJ case reports 7 21686408
2018 Strong correlation of ferrochelatase enzymatic activity with Mitoferrin-1 mRNA in lymphoblasts of patients with protoporphyria. Molecular genetics and metabolism 6 30391163
2024 Mitoferrin2 is a synthetic lethal target for chromosome 8p deleted cancers. Genome medicine 5 38886830
2023 Mycobacterial Spindle Cell Pseudotumor of the Nasal Cavity. Head and neck pathology 5 37027086
2024 Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria. Free radical research 4 38599240
2001 Rapid decrease of RNA level of a novel mouse mitochondria solute carrier protein (Mscp) gene at 4-5 weeks of age. Mammalian genome : official journal of the International Mammalian Genome Society 4 11845285
2025 Exploring the role of Mitoferrin-1 in Ferroptosis and mitochondrial damage in acute ischemic stroke. International immunopharmacology 3 40199135
2025 Shared molecular biomarkers and therapeutic targets in rheumatoid arthritis and osteoarthritis: Focus on EIF3B, KHSRP, NCL, PDCD1LG2, and SLC25A37. Cytokine 3 40592131
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2023 Congenital asplenia impairs heme-iron recycling during erythropoiesis in zebrafish. Developmental and comparative immunology 3 38040044
2025 The Physicochemical Properties and Anti-Fatigue Efficacy of a Polysaccharide-Rich Fraction Derived From Millettia speciosa Champ. Chemistry & biodiversity 2 40744024
2025 Proteolysis-triggered RNA Interference for Mitochondrial Iron Dyshomeostasis to Activate Antitumor Immunity in Hepatic Carcinoma. Advanced materials (Deerfield Beach, Fla.) 2 40757917
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2024 IL-1β primed mesenchymal stromal cells moderate hemorrhagic shock-induced vascular permeability. Journal of translational medicine 2 39719575
2023 Differences in Hepatocellular Iron Metabolism Underlie Sexual Dimorphism in Hepatocyte Ferroptosis. bioRxiv : the preprint server for biology 2 37425728
2017 Visualizing nuclear-localized RNA using transient expression system in plants. Genes to cells : devoted to molecular & cellular mechanisms 2 29271544
2025 RNA-Based Biomarkers of Iron Metabolism in Dried Blood Spots for Detecting Recombinant Human Erythropoietin in Doping Control. Drug testing and analysis 1 39976085
2025 Mycobacterial Spindle Cell Pseudotumor Presenting as a Pancreatic Head Mass: A Case Report. Pathogens (Basel, Switzerland) 1 41011789
2016 Population structure and diversity of citrus tristeza virus (CTV) isolates in Hunan province, China. Archives of virology 1 27771790
2026 Short-term black carbon exposure impairs mental health and DNA methylation signatures of mitochondrial carrier genes. Journal of hazardous materials 0 41518805
2026 Identification of key mitochondria-related genes in necrotizing enterocolitis using single-cell hdWGCNA and experimental verification. Pediatric research 0 41554862
2026 SLC25A37 as a novel therapeutic target for benign prostatic hyperplasia: integrative analyses of single-cell RNA sequencing and genome-wide association studies. Open medicine (Warsaw, Poland) 0 41726128
2026 Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer. Cancer biology & medicine 0 41821182
2026 Identification and validation of NETs-associated biomarkers in osteoporosis with diabetes. Scientific reports 0 41851246
2025 Mitochondrial iron transport via MFRN1 is required for erythroid cell cycle progression. Blood advances 0 40601908
2025 Polysaccharide Supplements from Millettia speciosa Champ. ex Benth Enhance Growth and Meat Quality in Wenchang Chickens. Biology 0 40723316
2025 Comparative structure-activity analysis of Millettia speciosa Champ polysaccharides and oligosaccharides in anti-inflammatory effects. International journal of biological macromolecules 0 41015357
2025 Vitamin C supplementation to pregnant smokers alters asthma- and allergy-associated CpGs in child buccal DNA at 5 years of age. Clinical epigenetics 0 41044653
2025 Identification of potential causal-genes-relevant blood pressure: a mitochondria-related genome-wide Mendelian randomization study. Journal of human hypertension 0 41238714
2025 SLC25A mitochondrial carriers as biomarkers and therapeutic targets of spaceflight-induced dysfunction: the ADP/ATP carrier (AAC3) as a structural case study. Journal of translational medicine 0 41469700
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