Affinage

SIRT7

NAD-dependent protein deacetylase sirtuin-7 · UniProt Q9NRC8

Length
400 aa
Mass
44.9 kDa
Annotated
2026-06-10
100 papers in source corpus 46 papers cited in narrative 46 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SIRT7 is a nucleolus-enriched, NAD+-dependent protein deacylase that integrates metabolic, genotoxic, and developmental signals at chromatin to control transcription, ribosome biogenesis, and genome stability (PMID:16618798, PMID:22722849, PMID:27997115). Its catalytic efficiency is strongly stimulated by nucleic acids—rRNA even more potently than DNA—and it removes not only acetyl but also long-chain fatty-acyl groups from lysines, with subsequent work extending its repertoire to decrotonylation and desuccinylation (PMID:26907567, PMID:27997115, PMID:34604215, PMID:39002692). In the nucleolus SIRT7 associates with active rDNA and RNA Pol I to drive rRNA transcription, deacetylates the U3 snoRNP component U3-55k to license pre-rRNA processing, and deacetylates fibrillarin to sustain H2AQ104 methylation and Pol I output, while also stabilizing rDNA heterochromatin through recruitment of DNMT1, SIRT1, and SNF2H (PMID:16618798, PMID:26867678, PMID:30540930, PMID:28842251, PMID:29728458). As an H3K18Ac deacetylase it is targeted to specific promoters by transcription factors including ELK4 and Myc to repress tumor-suppressive and ribosomal-protein genes, and it silences LINE-1 retrotransposons and maintains peripheral heterochromatin via interaction with Lamin A/C and HP1, restraining cGAS-STING innate immune activation (PMID:22722849, PMID:24210820, PMID:31226208, PMID:32504224). SIRT7 enforces genome integrity by deacetylating H3K18Ac at double-strand breaks to promote 53BP1 recruitment and NHEJ, deacetylating the DDX21 helicase to resolve R-loops, and deacetylating ATM to permit its WIP1-mediated deactivation during recovery from DNA damage (PMID:27225932, PMID:28790157, PMID:30944854). Beyond chromatin, SIRT7 deacetylation governs the stability or activity of numerous substrates—stabilizing p53 indirectly through NPM, promoting SMAD4 and MST1 degradation to modulate TGF-β/EMT and Hippo/YAP signaling, controlling Akt activity via FKBP51, activating Pol II elongation by deacetylating CDK9, and regulating mitochondrial gene expression through GABPβ1—thereby linking it to apoptosis, metastasis, and metabolic homeostasis (PMID:18239138, PMID:33495326, PMID:28827661, PMID:38288904, PMID:28147277, PMID:28426094, PMID:25200183). SIRT7 also restrains a second sirtuin by limiting SIRT1 autodeacetylation, and its own function is tuned by PRMT6-mediated R388 methylation, USP7-mediated K63 deubiquitination, OGT-mediated S136 O-GlcNAcylation, ATR phosphorylation, and HDAC8/SMAD3-4-dependent transcriptional repression, as well as cytoplasmic sequestration by Dicer (PMID:28923965, PMID:30420520, PMID:28655758, PMID:35422493, PMID:33495326, PMID:31970414, PMID:26704979).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2006 High

    Established SIRT7's foundational role by placing it in the nucleolus as a positive regulator of RNA Pol I transcription, answering where it acts and what process it controls.

    Evidence Co-IP with Pol I, ChIP at rDNA, knockdown/overexpression transcription assays

    PMID:16618798

    Open questions at the time
    • Did not define the catalytic substrate driving Pol I regulation
    • Mechanism of nucleolar targeting unresolved
  2. 2008 High

    Identified the first SIRT7 deacetylation substrate, p53, and linked SIRT7 to suppression of apoptosis, showing it acts beyond rDNA transcription.

    Evidence In vitro deacetylation assay and Sirt7 knockout mouse with cardiac p53 hyperacetylation

    PMID:18239138

    Open questions at the time
    • Direct versus indirect deacetylation of p53 not fully separated from later NPM-mediated mechanism
    • Specific p53 lysines not mapped
  3. 2012 High

    Defined SIRT7 as a selective H3K18Ac deacetylase recruited by ELK4 to repress tumor-suppressor promoters, establishing its chromatin-modifying activity and oncogenic role.

    Evidence Genome-wide ChIP-seq, in vitro deacetylation, knockdown, xenograft

    PMID:22722849

    Open questions at the time
    • Generality of H3K18Ac specificity across loci not exhaustive
    • Catalytic activation requirement not yet known
  4. 2013 High

    Mapped the sequence determinants of SIRT7 nuclear/nucleolar localization and revealed a cytoplasmic pool, addressing how its spatial distribution is controlled and linking nucleolar loss to senescence.

    Evidence Deletion/mutagenesis constructs, fractionation, immunocytochemistry; plus Myc-directed H3K18Ac deacetylation at ribosomal protein genes in a KO mouse

    PMID:23680022 PMID:24210820

    Open questions at the time
    • Trigger for cytoplasmic redistribution not defined here
    • Functional role of cytoplasmic pool unclear
  5. 2014 High

    Extended SIRT7 substrates to GABPβ1 and showed it controls an E3 ligase (DCAF1/DDB1/CUL4B) to stabilize TR4, connecting it to mitochondrial gene expression and hepatic lipid metabolism.

    Evidence In vitro deacetylation, co-IP, ubiquitination assays, whole-body and liver-specific KO mice

    PMID:24703702 PMID:25200183

    Open questions at the time
    • Whether ligase inhibition is deacetylation-dependent not fully resolved in the GABPβ1/TR4 arms
    • Tissue specificity of substrate selection unclear
  6. 2016 High

    Defined the biochemical basis of SIRT7 catalysis, showing RNA (especially rRNA) and DNA activate its deacylase activity and that it is an efficient defatty-acylase, answering how a weak deacetylase achieves activity in vivo.

    Evidence In vitro deacylase/defatty-acylase assays with DNA and RNA, RIP-seq, mutagenesis, metabolic labeling

    PMID:26907567 PMID:27997115

    Open questions at the time
    • Physiological balance between deacetylase and defatty-acylase functions unresolved
    • Structural mechanism of nucleic-acid activation not determined
  7. 2016 High

    Connected SIRT7 deacetylation to pre-rRNA processing (U3-55k) and to DNA double-strand break repair (PARP1-dependent recruitment, 53BP1, NHEJ), establishing dual nucleolar and genome-protective functions.

    Evidence In vitro deacetylation, RIP, rRNA processing assays, ChIP at DSBs, NHEJ assay, progeroid KO mouse

    PMID:26867678 PMID:27225932

    Open questions at the time
    • How SIRT7 partitions between rRNA processing and DSB repair not defined
    • Choice between NHEJ and HR pathways unaddressed
  8. 2017 High

    Greatly expanded the SIRT7 substrate network—DDX21 (R-loop resolution), SMAD4 (TGF-β/EMT), CDK9 (Pol II elongation), FKBP51 (Akt), FBL, and a SIRT1-restricting role—revealing SIRT7 as a multi-pathway signaling deacetylase.

    Evidence In vitro deacetylation, helicase assays, ubiquitination assays, mutagenesis, ChIP, KO mice and epistasis

    PMID:28147277 PMID:28426094 PMID:28790157 PMID:28827661 PMID:28923965

    Open questions at the time
    • Combinatorial logic governing substrate choice unknown
    • Relative in vivo contribution of each substrate unquantified
  9. 2017 High

    Established multiple layers of SIRT7 regulation and target circuits—USP7 K63-deubiquitination represses activity, HDAC8/SMAD3-4 repress SIRT7 transcription, and SIRT7 maintains rDNA heterochromatin via DNMT1/SIRT1—showing SIRT7 sits in feedback loops.

    Evidence In vitro deubiquitination/deacetylation, ChIP, reporter assays, bisulfite sequencing, KO cells/mice

    PMID:28655758 PMID:28842251 PMID:31970414

    Open questions at the time
    • How K63 deubiquitination mechanistically represses catalysis unknown
    • Interplay between the repressive and activating inputs not integrated
  10. 2018 High

    Identified PRMT6-mediated R388 methylation as a glucose- and AMPK-responsive switch on SIRT7 activity and connected SIRT7 to FBL/H2AQ104me-dependent Pol I control and rDNA-stability-dependent senescence, coupling metabolism to ribosome biogenesis.

    Evidence In vitro methylation/deacetylation assays, mutagenesis, AMPK activation, ChIP, rDNA copy and senescence assays

    PMID:29728458 PMID:30420520 PMID:30540930

    Open questions at the time
    • Whether other PTMs cooperate with R388 methylation unresolved
    • SNF2H recruitment mechanism (29728458, Medium) not biochemically reconstituted
  11. 2019 High

    Defined SIRT7's role in ATM deactivation, LINE-1 silencing via Lamin A/C, CRY1-dependent circadian control, and meiotic chromosome synapsis, broadening its functions into DNA-damage recovery, retrotransposon control, the clock, and reproduction.

    Evidence In vitro deacetylation, chromatin fractionation, ChIP-seq, retrotransposition and ubiquitination assays, KO mouse circadian and meiotic phenotypes

    PMID:30944854 PMID:31226208 PMID:31256246 PMID:32694864

    Open questions at the time
    • Substrate(s) underlying meiotic phenotype beyond H3K18Ac unidentified
    • How a single enzyme coordinates these disparate programs unclear
  12. 2020 High

    Revealed a novel auto-mono-ADP-ribosyltransferase activity with a distinct active site, plus heterochromatin/cGAS-STING control and stress-driven relocalization (DDB1/CRL4, NPM-p53), showing SIRT7 possesses a second catalytic function and senses genotoxic/nutrient stress through subnuclear redistribution.

    Evidence MS identification of ADP-ribosylation, active-site mutagenesis, co-IP, ATR phosphorylation assay, KO mice with calorie restriction or UV

    PMID:28886238 PMID:32404984 PMID:32504224 PMID:32832656 PMID:33495326

    Open questions at the time
    • Physiological substrates of the mADPRT activity beyond auto-modification unknown
    • Coordination of relocalization signals across stresses not unified
  13. 2022 High

    Identified additional post-translational control (OGT S136 O-GlcNAcylation blocking REGγ-mediated degradation) and metabolic substrates (IGF2BP2/Ucp1, PPARγ2), connecting SIRT7 stability and activity to nutrient signaling and adipose/thermogenic physiology.

    Evidence MS modification mapping, site mutants, co-IP, translation assays, tissue-specific KO mice, xenograft

    PMID:33955199 PMID:35422493 PMID:36509749

    Open questions at the time
    • Crosstalk between O-GlcNAcylation, methylation, and ubiquitination not resolved
    • Tissue-specific determinants of substrate choice unknown
  14. 2024 Medium

    Extended SIRT7's acyl-removing repertoire (decrotonylation of PHF5A, desuccinylation of KIF23 and histone H3K122) and added KLF4, MST1/Hippo-YAP, DDX3X, and FAM134B/ER-phagy substrates, showing SIRT7 acts on multiple acyl marks across diverse disease contexts.

    Evidence MS, site-specific mutants, ubiquitination/deacylation assays, ChIP, tissue-specific KO and xenograft models

    PMID:34604215 PMID:37043189 PMID:38198357 PMID:38277756 PMID:38288904 PMID:38360598 PMID:39002692

    Open questions at the time
    • Several desuccinylation/decrotonylation activities (Medium) lack in vitro reconstitution
    • Whether non-acetyl acyl removals are physiologically dominant unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SIRT7's single catalytic core is directed among its many substrates and two enzymatic activities, and how the converging metabolic, genotoxic, and developmental inputs are integrated into substrate-specific outcomes, remains unresolved.
  • No unifying model for substrate selectivity
  • Relative in vivo weighting of deacetylase versus defatty-acylase versus mADPRT activities undetermined
  • Structural basis of nucleic-acid-activated catalysis not solved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 18 GO:0098772 molecular function regulator activity 3 GO:0003723 RNA binding 2 GO:0003677 DNA binding 1 GO:0016740 transferase activity 1 GO:0140097 catalytic activity, acting on DNA 1
Localization
GO:0005730 nucleolus 4 GO:0005634 nucleus 3 GO:0000228 nuclear chromosome 2 GO:0005654 nucleoplasm 2 GO:0005829 cytosol 2
Pathway
R-HSA-1430728 Metabolism 4 R-HSA-4839726 Chromatin organization 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-162582 Signal Transduction 3 R-HSA-73894 DNA Repair 3 R-HSA-8953854 Metabolism of RNA 2 R-HSA-168256 Immune System 1 R-HSA-9909396 Circadian clock 1
Partners
ATMCDK9DDX21ELK4LAMIN A/CMYCSIRT1SMAD4

Evidence

Reading pass · 46 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 SIRT7 localizes to the nucleolus, associates with active rRNA genes (rDNA), interacts with RNA Polymerase I and histones, and positively regulates Pol I-mediated transcription; knockdown reduces Pol I association with rDNA and decreases rRNA transcription, while overexpression increases it. Co-immunoprecipitation, chromatin immunoprecipitation, siRNA knockdown, overexpression with transcription assays Genes & development High 16618798
2008 SIRT7 interacts with p53 and deacetylates p53 in vitro; Sirt7 knockout mice show hyperacetylation of p53 in vivo and increased cardiomyocyte apoptosis, indicating SIRT7 suppresses p53-dependent apoptosis in the heart. Co-immunoprecipitation, in vitro deacetylation assay, Sirt7 knockout mouse model, immunoblot for acetylated p53 Circulation research High 18239138
2012 SIRT7 is an NAD+-dependent H3K18Ac deacetylase that binds promoters of tumor-suppressive genes through interaction with the ETS transcription factor ELK4, deacetylates H3K18Ac to repress transcription, and is necessary for maintaining cancer cell transformation and global H3K18Ac hypoacetylation. Genome-wide ChIP-seq, in vitro deacetylation assay, siRNA knockdown, xenograft mouse model, co-immunoprecipitation with ELK4 Nature High 22722849
2013 SIRT7 nuclear/nucleolar localization is governed by two distinct N-terminal (aa 61-76) and C-terminal (aa 392-400) sequence elements; a cytoplasmic pool of SIRT7 also exists, and loss of nucleolar SIRT7 associates with replicative senescence. Deletion constructs, site-directed mutagenesis, immunocytochemistry, subcellular fractionation, RNAi, peptide competition assay The FEBS journal High 23680022
2013 SIRT7 functions at chromatin as an NAD+-dependent H3K18Ac deacetylase that interacts with the transcription factor Myc at ribosomal protein gene promoters to silence expression and relieve ER stress; SIRT7-deficient mice develop chronic hepatosteatosis. ChIP, co-immunoprecipitation with Myc, siRNA knockdown, Sirt7 knockout mouse model, pharmacologic ER stress suppression rescue Cell reports High 24210820
2014 SIRT7 deacetylates GABPβ1 at specific lysine residues in its dimerization domains, facilitating GABPβ1/GABPα complex formation and transcriptional activation of nuclear-encoded mitochondrial genes; Sirt7 deficiency in mice causes multisystemic mitochondrial dysfunction. In vitro deacetylation assay, co-immunoprecipitation, Sirt7 knockout mouse model with mitochondrial functional measurements, rescue with SIRT7 overexpression in patient fibroblasts Cell metabolism High 25200183
2014 SIRT7 binds the DCAF1/DDB1/CUL4B E3 ubiquitin ligase complex and inhibits it from ubiquitinating and degrading the nuclear receptor TR4, thereby upregulating TR4 target genes that promote fatty acid uptake and triglyceride synthesis in liver. Co-immunoprecipitation, ubiquitination assay, Sirt7 knockout mouse on high-fat diet, liver-specific Sirt7 knockout Cell metabolism High 24703702
2015 SIRT7 directly interacts with SIRT1, representing the first demonstration of direct interaction and functional interplay between two mammalian sirtuins; SIRT7 inactivation suppresses metastasis in vivo in both epithelial and mesenchymal cancer models. Co-immunoprecipitation, in vivo metastasis assay, siRNA knockdown Scientific reports Medium 25923013
2016 SIRT7 is recruited to DNA double-strand break (DSB) sites in a PARP1-dependent manner, where it deacetylates H3K18Ac to promote 53BP1 recruitment and efficient non-homologous end joining (NHEJ) repair; SIRT7-deficient mice show increased replication stress and a progeroid phenotype. Chromatin immunoprecipitation at DSBs, PARP1 dependency experiments, NHEJ repair assay, SIRT7 knockout mouse model, 53BP1 focal accumulation assay The EMBO journal High 27225932
2016 SIRT7 deacetylates U3-55k, a core component of the U3 snoRNP complex; deacetylation enhances U3-55k binding to U3 snoRNA, which is required for pre-rRNA cleavage steps generating 18S rRNA. Under stress, SIRT7 is released from nucleoli, causing hyperacetylation of U3-55k and attenuation of pre-rRNA processing. In vitro deacetylation assay, RNA immunoprecipitation, siRNA knockdown, rRNA processing assays, nucleolar fractionation under stress Nature communications High 26867678
2016 DNA activates SIRT7 deacetylase activity in vitro, allowing it to deacetylate H3K18 in the chromatin context; both N- and C-termini are important for this DNA-activated activity, and the mechanism differs from that of SIRT6. In vitro deacetylation assay with DNA, truncation and mutagenesis, chromatin deacetylation assay ACS chemical biology High 26907567
2016 RNA (especially rRNA) activates SIRT7 catalytic efficiency even more potently than DNA, and SIRT7 can remove long-chain fatty acyl groups from lysines (defatty-acylase activity) more efficiently than acetyl groups; truncation/mutagenesis identified N- and C-terminal residues involved in RNA binding and activity. RIP-seq identified rRNA as the predominant RNA binding partner. In vitro deacetylase/defatty-acylase assay, RNA immunoprecipitation-sequencing, truncation/mutagenesis, metabolic labeling with alkyne-tagged fatty acid analog ACS chemical biology High 27997115
2017 SIRT7 deacetylates DDX21 (a DEAD-box helicase); deacetylation by SIRT7 augments DDX21 helicase activity to unwind R-loops, while acetylation by CBP inhibits DDX21. Knockdown of SIRT7 phenocopies DDX21 depletion, causing R-loop accumulation and DNA double-strand breaks. In vitro helicase/deacetylation assay, siRNA knockdown, R-loop detection (S9.6 antibody), DNA damage assay, co-immunoprecipitation Genes & development High 28790157
2017 SIRT7 deacetylates SMAD4, promoting its degradation via β-TrCP1-mediated ubiquitination; SIRT7 deficiency stabilizes SMAD4, activates TGF-β signaling, and enhances epithelial-to-mesenchymal transition and breast cancer metastasis. Co-immunoprecipitation, in vitro deacetylation assay, ubiquitination assay, siRNA/shRNA knockdown, in vivo metastasis mouse model Nature communications High 28827661
2017 SIRT7 deacetylates CDK9 (a subunit of P-TEFb) at lysine 48, counteracting GCN5-directed acetylation; deacetylation promotes P-TEFb release from the inactive 7SK snRNP complex and activates CDK9-mediated CTD phosphorylation and Pol II transcription elongation. Proteomic co-IP, in vitro deacetylation assay, ChIP, Pol II CTD phosphorylation assay, siRNA knockdown Nucleic acids research High 28426094
2017 SIRT7 deacetylates FKBP51 at K28 and K155, which enhances the interaction of FKBP51 with Akt and PHLPP, leading to Akt dephosphorylation; mutation of both lysines to arginine abolishes SIRT7-mediated Akt dephosphorylation. Co-immunoprecipitation, in vitro deacetylation assay, site-directed mutagenesis (K28R/K155R), phospho-Akt immunoblot, siRNA knockdown Cell reports High 28147277
2017 Sirt7 restricts Sirt1 activity by preventing Sirt1 autodeacetylation; increased Sirt1 activity in Sirt7-/- mice blocks PPARγ and adipocyte differentiation, and reducing Sirt1 activity restores adipogenesis in Sirt7-/- cells. In vitro deacetylation assay, Sirt7 knockout mouse model, Sirt1 activity assays, adipocyte differentiation rescue experiments, genetic epistasis Proceedings of the National Academy of Sciences of the United States of America High 28923965
2017 USP7 interacts with SIRT7 and removes K63-linked polyubiquitin chains from SIRT7; while deubiquitination does not affect SIRT7 stability, it represses SIRT7 enzymatic activity. SIRT7 targets the G6PC gluconeogenic gene promoter through ELK4. Co-immunoprecipitation, in vitro deubiquitination assay, ubiquitination linkage analysis, in vitro deacetylation assay, ChIP The Journal of biological chemistry High 28655758
2017 Sirt7 stabilizes rDNA heterochromatin by recruiting DNA methyltransferase 1 (DNMT1) and Sirt1 to rDNA loci; Sirt7 loss leads to nucleolar fragmentation, rDNA hypomethylation, and histone hyperacetylation at rDNA. Co-immunoprecipitation, ChIP, bisulfite sequencing (rDNA methylation), Sirt7 knockout cells/mice Biochemical and biophysical research communications Medium 28842251
2017 SIRT7 deacetylates DDB1, reducing DDB1 binding to CUL4 and suppressing CRL4 E3 ubiquitin ligase activity; upon nucleolar stress (actinomycin D or 5-FU), SIRT7 redistributes from nucleolus to nucleoplasm to promote DDB1 deacetylation, leading to accumulation of CRL4 substrates including LATS1 and p73. In vitro deacetylation assay, co-immunoprecipitation, siRNA knockdown, actinomycin D/5-FU nucleolar stress treatment, immunoblot for CRL4 substrates The FEBS journal High 28886238
2018 SIRT7 deacetylates fibrillarin (FBL); hyperacetylation of FBL impairs its interaction with histone H2A and chromatin, compromising H2AQ104 methylation (H2AQ104me) and rDNA transcription. SIRT7-dependent deacetylation of FBL ensures H2AQ104me and high rRNA synthesis during interphase; at mitotic onset, hyperacetylation of FBL accompanies loss of H2AQ104me and Pol I repression. In vitro deacetylation assay (CBP acetylates, SIRT7 deacetylates FBL), acetylation-deficient/mimicking FBL mutants, H2AQ104me immunoblot, co-immunoprecipitation, ChIP Cell reports High 30540930
2018 PRMT6 directly methylates SIRT7 at arginine 388 (R388) in vitro and in vivo, inhibiting its H3K18 deacetylase activity without altering subcellular localization. AMPK disrupts PRMT6-SIRT7 association, causing R388 hypomethylation. High glucose enhances R388 methylation, coupling glucose availability to mitochondria biogenesis via SIRT7. In vitro methylation assay, co-immunoprecipitation, SIRT7 deacetylase activity assay with R388 mutant, AMPK activation experiments, immunoblot in mouse liver EMBO reports High 30420520
2018 SIRT7 interacts with and deacetylates PPARγ2 at K382; acetylation-mimicking K382Q mutation impairs lipogenesis gene expression (Srebp1c, Acaca, Fasn, Scd1) and reduces PPARγ2 transcriptional activity in adipocytes. Co-immunoprecipitation, in vitro deacetylation assay, site-directed mutagenesis (K382Q and K382R), global gene expression analysis, transcriptional activity assay Journal of diabetes investigation High 33955199
2019 SIRT7 interacts with and deacetylates ATM in vitro and in vivo; SIRT7-mediated ATM deacetylation is prerequisite for ATM dephosphorylation by phosphatase WIP1. SIRT7 is mobilized onto chromatin during late stages of DNA damage response to deactivate ATM; SIRT7 depletion or acetylation-mimic ATM mutation causes persistent ATM phosphorylation and impaired DNA repair. Co-immunoprecipitation, in vitro deacetylation assay, chromatin fractionation, phospho-ATM immunoblot, acetylation-mimicking ATM mutation, DNA repair assays Science advances High 30944854
2019 SIRT7 mediates H3K18 deacetylation-dependent epigenetic repression of LINE-1 (L1) retrotransposons genome-wide; SIRT7 interacts with Lamin A/C to promote L1 association with the nuclear lamina. SIRT7 depletion causes increased L1 expression and retrotransposition. ChIP-seq, siRNA knockdown, L1 retrotransposition assay, co-immunoprecipitation with Lamin A/C, SIRT7 KO mouse and human cells Nucleic acids research High 31226208
2019 SIRT7 deacetylates CRY1 and promotes its FBXL3-mediated degradation, thereby regulating the hepatic circadian clock. Body temperature oscillations drive HSP70 expression, which promotes SIRT7 ubiquitination and degradation, establishing a BT-HSP70-SIRT7-CRY1 axis coupling the hepatic clock to the central pacemaker. Co-immunoprecipitation, in vitro deacetylation assay, Sirt7 knockout mouse model with circadian phase analysis, ubiquitination assay, CRY1 stability assay Nature metabolism High 32694864
2019 SIRT7 forms a complex with MEF2D that attenuates MEF2D acetylation and reduces MEF2D-driven PD-L1 expression in hepatocellular carcinoma; IFNG-induced p300 acetylates MEF2D and disrupts the MEF2D-SIRT7 interaction, enabling PD-L1 transcription. Co-immunoprecipitation, pulldown assay, ChIP, dual luciferase reporter, SIRT7 knockout in cell lines and orthotopic mouse model Gastroenterology High 31678303
2020 SIRT7 forms a complex with nuclear lamina proteins and heterochromatin proteins to maintain repressive heterochromatin at the nuclear periphery; SIRT7 deficiency leads to loss of heterochromatin, de-repression of LINE1, and activation of innate immune signaling via the cGAS-STING pathway in human mesenchymal stem cells. Co-immunoprecipitation with Lamin and HP1 proteins, ChIP, LINE1 expression assay, cGAS-STING pathway activation assay, SIRT7 KD/KO in hMSCs Protein & cell High 32504224
2020 SirT7 exhibits auto-mono-ADP-ribosyltransferase (mADPRT) activity at a previously undefined active site distinct from its deacetylase active site; ADP-ribosyl-SirT7 is recognized by the ADP-ribose reader mH2A1.1 under glucose starvation, inducing SirT7 relocalization to intergenic regions and regulating gene expression involved in second-messenger signaling and autophagy. Mass spectrometry identification of ADP-ribosylation, site-directed mutagenesis of mADPRT active site, chromatin distribution assay, SirT7 KO mouse with calorie restriction Science advances High 32832656
2020 SIRT7 directly interacts with and deacetylates PCAF at K720; PCAF deacetylation augments its binding to MDM2 (the p53 E3 ligase), leading to MDM2 degradation, p21 upregulation, and cell-cycle arrest under glucose deprivation conditions. Co-immunoprecipitation, in vitro deacetylation assay, MDM2 ubiquitination/degradation assay, p21/p53 immunoblot under glucose deprivation, SIRT7 depletion Oncogene High 32404984
2020 SIRT7 deacetylates NPM (nucleophosmin); ATR-mediated phosphorylation of SIRT7 upon UV irradiation increases its catalytic activity. Deacetylated NPM relocates to the nucleoplasm and binds MDM2, preventing p53 ubiquitination and degradation, thus stabilizing p53 during genotoxic stress. In vitro deacetylation assay, ATR phosphorylation assay, NPM relocalization assay, co-immunoprecipitation with MDM2, p53 stability assay in vitro and in vivo (KO mouse UV response) Proceedings of the National Academy of Sciences of the United States of America High 33495326
2020 Progerin (HGPS mutant Lamin A) interacts with and destabilizes SIRT7; ectopic SIRT7 expression alleviates progerin-induced inflammatory response in vascular endothelial cells. Co-immunoprecipitation of progerin-SIRT7, endothelial cell overexpression, inflammatory marker assay, Tie2-Cre Lmna progerin knock-in mouse model Science advances Medium 32128409
2021 SIRT7 decrotonylates PHF5A at K25; this PHF5A decrotonylation contributes to decreased CDK2 expression via retained intron-induced abnormal alternative splicing, thereby accelerating fibroblast senescence. Mass spectrometry identification of crotonylation sites, SIRT7 knockdown/overexpression, immunoblot for Kcr, co-IP, CDK2 splicing analysis Frontiers in cell and developmental biology Medium 34604215
2022 SIRT7 deacetylates insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), enhancing its inhibitory action on Ucp1 mRNA translation, thereby suppressing UCP1 protein levels and brown adipose tissue thermogenesis; Sirt7 knockout mice have higher body temperature and energy expenditure. Sirt7 whole-body and BAT-specific knockout mice, UCP1 protein immunoblot, in vitro deacetylation assay, Ucp1 mRNA translation assay Nature communications High 36509749
2022 O-GlcNAcylation of SIRT7 at serine 136 (S136) by OGT stabilizes SIRT7 protein by blocking its interaction with the proteasome activator REGγ, preventing SIRT7 degradation; SIRT7 O-GlcNAcylation is required for its H3K18 deacetylase activity and oncogenic function in pancreatic cancer. Mass spectrometry (OGT interaction and S136 modification), co-immunoprecipitation, S136A mutant, H3K18ac immunoblot, in vivo xenograft Cell death and differentiation High 35422493
2023 SIRT7 deacetylates FAM134B (an ER-phagy receptor), counteracting CBP-mediated acetylation that promotes ER-phagy; SIRT7-mediated deacetylation tempers FAM134B activity to avoid excessive ER degradation, maintaining ER homeostasis. Co-immunoprecipitation, in vitro deacetylation assay, ER-phagy assay, CBP/SIRT7 gain- and loss-of-function The Journal of cell biology High 37043189
2024 SIRT7 suppresses MST1 (a Hippo pathway kinase) by two mechanisms: (1) binding to the MST1 promoter and inducing H3K18 deacetylation to repress transcription, and (2) directly binding and deacetylating MST1 protein, which primes acetylation-dependent MST1 ubiquitination and degradation; this promotes YAP nuclear localization and activation in hepatocellular carcinoma. ChIP, luciferase reporter assay, co-immunoprecipitation, mass spectrometry (deacetylation), ubiquitination assay, xenograft mouse model Cancer science High 38288904
2024 SIRT7 deacetylates KLF4 (Krüppel-like factor 4) at K228, inhibiting its ubiquitination-proteasome degradation; the SIRT7/KLF4 axis maintains pulmonary arterial endothelial cell homeostasis; endothelium-specific SIRT7 depletion exacerbates pulmonary hypertension. Co-immunoprecipitation, deacetylation assay, ubiquitination assay, endothelium-specific Sirt7 KO mouse in SuHx PH model, AAV-mediated SIRT7 overexpression rescue Cardiovascular research High 38198357
2024 SIRT7 interacts with DDX3X and deacetylates it; SIRT7-mediated DDX3X deacetylation promotes DDX3X protein stability. SIRT7 inhibition leads to DDX3X depletion, disruption of NLRP3 inflammasome assembly, and suppression of ERK1/2 signaling, re-sensitizing cells to sorafenib. Mass spectrometry (DDX3X as SIRT7 target), co-immunoprecipitation, DDX3X deacetylation assay, NLRP3 inflammasome assay, in vivo xenograft with SIRT7 inhibitors Drug resistance updates Medium 38277756
2024 SIRT7 directly interacts with KIF23 and catalyzes its desuccinylation at K537, which enhances KIF23 protein stability and promotes anaplastic thyroid cancer cell proliferation and migration. Co-immunoprecipitation, succinylation immunoblot with K537 mutant, SIRT7 overexpression/knockdown, cell viability and migration assay BMC cancer Medium 38360598
2024 SIRT7 directly interacts with the GLUT3 enhancer region and desuccinylates H3K122 at that locus, repressing GLUT3 expression; SIRT7 knockdown upregulates GLUT3 and sensitizes pancreatic cancer cells to gemcitabine. ChIP, co-IP, H3K122 succinylation immunoblot, ATAC-seq/RNA-seq cross-analysis, SIRT7 KD with gemcitabine sensitivity assay, xenograft mouse model Cancer letters Medium 39002692
2017 HDAC8 forms a complex with SMAD3/4 and occupies the SIRT7 promoter, where it deacetylates H4 to transcriptionally suppress SIRT7 expression; this establishes a TGF-β/HDAC8/SMAD3-4/SIRT7 regulatory feedback loop. Co-immunoprecipitation, ChIP, siRNA knockdown of HDAC8/SMAD3/4, luciferase reporter assay, H4 acetylation immunoblot at SIRT7 promoter Nucleic acids research High 31970414
2015 Dicer interacts with SIRT7 and sequesters a proportion of SIRT7 in the cytoplasm; Dicer knockdown increases chromatin-associated SIRT7 and decreases H3K18Ac, while Dicer overexpression reduces chromatin-associated SIRT7 and increases H3K18Ac levels. DNA damaging agents promote Dicer expression to trap SIRT7 in the cytoplasm. Co-immunoprecipitation, subcellular fractionation, siRNA/overexpression of Dicer, H3K18Ac immunoblot, DNA damage treatment Nucleic acids research Medium 26704979
2019 SIRT7 promotes chromosome synapsis in female meiosis; Sirt7 KO oocytes show increased unsynapsed chromosomes with elevated H3K18Ac at asynaptic regions, fewer MLH1 crossover foci, and increased aneuploidy in metaphase II eggs. Sirt7 KO mouse model, immunofluorescence (H3K18Ac, γH2AX, SYCP3, MLH1), aneuploidy assessment, oocyte counting Chromosoma High 31256246
2018 SIRT7 is required for spindle organization, cortical actin cap formation, and redox homeostasis during mouse oocyte meiotic maturation; SIRT7 depletion elevates ROS and causes chromosome misalignment and aneuploidy. SIRT7 protein is decreased in oocytes from obese mice, and exogenous SIRT7 rescues obesity-associated meiotic defects. Specific knockdown in mouse oocytes (morpholino/siRNA), immunofluorescence for spindle/chromosomes/actin, ROS measurement, obesity mouse model rescue experiment FASEB journal High 29879377
2018 SIRT7 protects against rDNA instability-induced senescence in human primary cells by promoting association of the chromatin remodeler SNF2H with rDNA sequences; SIRT7-deficient cells show rDNA copy loss and acute senescence. ChIP for SNF2H at rDNA, rDNA copy number assay, SIRT7 depletion in primary human cells, senescence assays The Journal of biological chemistry Medium 29728458

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circulation research 523 18239138
2012 SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 502 22722849
2006 Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes & development 479 16618798
2013 SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell reports 237 24210820
2014 A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function. Cell metabolism 222 25200183
2016 SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair. The EMBO journal 220 27225932
2017 SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability. Genes & development 198 28790157
2017 SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis. Nature communications 181 28827661
2014 SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway. Cell metabolism 176 24703702
2020 SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein & cell 128 32504224
2016 SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing. Nature communications 114 26867678
2019 SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair. Science advances 105 30944854
2013 Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal. The FEBS journal 105 23680022
2015 SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors. Scientific reports 99 25923013
2015 Sirt7 promotes gastric cancer growth and inhibits apoptosis by epigenetically inhibiting miR-34a. Scientific reports 97 25860861
2019 Disruption of SIRT7 Increases the Efficacy of Checkpoint Inhibitor via MEF2D Regulation of Programmed Cell Death 1 Ligand 1 in Hepatocellular Carcinoma Cells. Gastroenterology 96 31678303
2017 The seven faces of SIRT7. Transcription 95 28067587
2020 Vascular endothelium-targeted Sirt7 gene therapy rejuvenates blood vessels and extends life span in a Hutchinson-Gilford progeria model. Science advances 89 32128409
2016 SIRT7 Is an RNA-Activated Protein Lysine Deacylase. ACS chemical biology 89 27997115
2017 Regulation of Serine-Threonine Kinase Akt Activation by NAD+-Dependent Deacetylase SIRT7. Cell reports 81 28147277
2017 Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1. Proceedings of the National Academy of Sciences of the United States of America 81 28923965
2020 HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration. Nucleic acids research 78 31970414
2014 Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging. Proteomics 76 24782448
2018 Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis. EMBO reports 75 30420520
2019 SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway. Journal of experimental & clinical cancer research : CR 74 31196136
2022 SIRT7 in the aging process. Cellular and molecular life sciences : CMLS 73 35585284
2022 O-GlcNAcylation and stablization of SIRT7 promote pancreatic cancer progression by blocking the SIRT7-REGγ interaction. Cell death and differentiation 72 35422493
2018 SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A Methylation and rRNA Synthesis during the Cell Cycle. Cell reports 72 30540930
2017 Sirtuins and DNA damage repair: SIRT7 comes to play. Nucleus (Austin, Tex.) 71 28406750
2018 Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7. Frontiers in endocrinology 67 30510540
2017 Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer. Theranostics 62 28435470
2020 SIRT7 depletion inhibits cell proliferation and androgen-induced autophagy by suppressing the AR signaling in prostate cancer. Journal of experimental & clinical cancer research : CR 61 32019578
2015 Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents. Nucleic acids research 61 26704979
2019 SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina. Nucleic acids research 60 31226208
2018 The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability. The Journal of biological chemistry 60 29728458
2016 SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context. ACS chemical biology 60 26907567
2018 SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation. Journal of experimental & clinical cancer research : CR 59 30001742
2017 Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis. The Journal of biological chemistry 58 28655758
2016 SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status. International journal of obesity (2005) 57 27480132
2018 SIRT7 Regulates the Vascular Smooth Muscle Cells Proliferation and Migration via Wnt/β-Catenin Signaling Pathway. BioMed research international 55 30627559
2021 SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress. Proceedings of the National Academy of Sciences of the United States of America 52 33495326
2020 SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1. Science advances 52 32832656
2015 SIRT7 Exhibits Oncogenic Potential in Human Ovarian Cancer Cells. Asian Pacific journal of cancer prevention : APJCP 52 25921180
2017 SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription. Nucleic acids research 51 28426094
2021 SIRT7: a sentinel of genome stability. Open biology 49 34129782
2018 SIRT7 promotes thyroid tumorigenesis through phosphorylation and activation of Akt and p70S6K1 via DBC1/SIRT1 axis. Oncogene 49 30093629
2014 Molecular pathways: emerging roles of mammalian Sirtuin SIRT7 in cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 49 24536059
2023 SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation. Signal transduction and targeted therapy 48 36918544
2018 Identification of a novel SIRT7 inhibitor as anticancer drug candidate. Biochemical and biophysical research communications 45 30503501
2015 Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 43 25794641
2020 SIRT7-mediated modulation of glutaminase 1 regulates TGF-β-induced pulmonary fibrosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 40 32519817
2021 SIRT7-Induced PHF5A Decrotonylation Regulates Aging Progress Through Alternative Splicing-Mediated Downregulation of CDK2. Frontiers in cell and developmental biology 39 34604215
2020 SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem-cell disorders. Leukemia 39 32214204
2020 SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle. Oncogene 35 32404984
2019 SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-κB Signaling Pathway. Oxidative medicine and cellular longevity 35 31285783
2019 SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis. Nature metabolism 34 32694864
2018 SIRT7 depletion inhibits cell proliferation, migration, and increases drug sensitivity by activating p38MAPK in breast cancer cells. Journal of cellular physiology 30 29231244
2024 SIRT7 promotes Hippo/YAP activation and cancer cell proliferation in hepatocellular carcinoma via suppressing MST1. Cancer science 29 38288904
2023 MiR-21-5p promotes sorafenib resistance and hepatocellular carcinoma progression by regulating SIRT7 ubiquitination through USP24. Life sciences 29 37187452
2022 SIRT1-SIRT7 in Diabetic Kidney Disease: Biological Functions and Molecular Mechanisms. Frontiers in endocrinology 29 35634495
2022 SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice. Nature communications 29 36509749
2020 SIRT7 deficiency suppresses inflammation, induces EndoMT, and increases vascular permeability in primary pulmonary endothelial cells. Scientific reports 29 32719338
2020 Sirt7 protects chondrocytes degeneration in osteoarthritis via autophagy activation. European review for medical and pharmacological sciences 29 33015765
2024 SIRT7: a novel molecular target for personalized cancer treatment? Oncogene 28 38383727
2020 lncRNA‑SNHG7‑003 inhibits the proliferation, migration and invasion of vascular smooth muscle cells by targeting the miR‑1306‑5p/SIRT7 signaling pathway. International journal of molecular medicine 28 33416100
2018 SIRT7 functions in redox homeostasis and cytoskeletal organization during oocyte maturation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28 29879377
2016 SIRT7, H3K18ac, and ELK4 Immunohistochemical Expression in Hepatocellular Carcinoma. Journal of pathology and translational medicine 28 27498548
2014 The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma. Anticancer research 28 25503141
2022 Discovery of SIRT7 Inhibitor as New Therapeutic Options Against Liver Cancer. Frontiers in cell and developmental biology 27 35174171
2013 SIRT7 an emerging sirtuin: deciphering newer roles. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 26 24304566
2019 SIRT7 promotes chromosome synapsis during prophase I of female meiosis. Chromosoma 25 31256246
2017 Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation. PloS one 25 28582407
2017 Sirt7 stabilizes rDNA heterochromatin through recruitment of DNMT1 and Sirt1. Biochemical and biophysical research communications 25 28842251
2022 Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation. Translational research : the journal of laboratory and clinical medicine 24 35470010
2023 A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy. The Journal of cell biology 23 37043189
2022 Downregulation of LINC00886 facilitates epithelial-mesenchymal transition through SIRT7/ELF3/miR-144 pathway in esophageal squamous cell carcinoma. Clinical & experimental metastasis 23 35616822
2020 MiR-770 promotes oral squamous cell carcinoma migration and invasion by regulating the Sirt7/Smad4 pathway. IUBMB life 23 33326690
2018 Silencing forkhead box M1 promotes apoptosis and autophagy through SIRT7/mTOR/IGF2 pathway in gastric cancer cells. Journal of cellular biochemistry 23 29953672
2017 Transcriptional Regulation of Metabolism by SIRT1 and SIRT7. International review of cell and molecular biology 23 29305011
2024 Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 22 38277756
2023 Resveratrol rescues cutaneous radiation-induced DNA damage via a novel AMPK/SIRT7/HMGB1 regulatory axis. Cell death & disease 22 36587031
2022 H2O2 down-regulates SIRT7's protective role of endothelial premature dysfunction via microRNA-335-5p. Bioscience reports 22 34981113
2015 Novel protein-protein interactions of TPPII, p53, and SIRT7. Molecular and cellular biochemistry 22 26169984
2024 Endothelium-specific SIRT7 targeting ameliorates pulmonary hypertension through Krüpple-like factor 4 deacetylation. Cardiovascular research 21 38198357
2024 SIRT7 promotes the proliferation and migration of anaplastic thyroid cancer cells by regulating the desuccinylation of KIF23. BMC cancer 21 38360598
2022 Trilobatin promotes angiogenesis after cerebral ischemia-reperfusion injury via SIRT7/VEGFA signaling pathway in rats. Phytotherapy research : PTR 21 35537702
2022 NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7. Free radical biology & medicine 21 36252808
2021 SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARγ2. Journal of diabetes investigation 21 33955199
2017 Suppression of microRNA-142-5p attenuates hypoxia-induced apoptosis through targeting SIRT7. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 21 28772218
2024 Zn2+ improves sepsis-induced acute kidney injury by upregulating SIRT7-mediated Parkin acetylation. American journal of physiology. Renal physiology 20 38779758
2023 USP39 interacts with SIRT7 to promote cervical squamous cell carcinoma by modulating autophagy and oxidative stress via FOXM1. Journal of translational medicine 20 37957720
2021 SIRT7 interacts with TEK (TIE2) to promote adriamycin induced metastasis in breast cancer. Cellular oncology (Dordrecht, Netherlands) 20 34797559
2015 C/EBPα negatively regulates SIRT7 expression via recruiting HDAC3 to the upstream-promoter of hepatocellular carcinoma cells. Biochimica et biophysica acta 20 26704017
2018 SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development. Biochemical and biophysical research communications 19 29402405
2017 SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. The FEBS journal 19 28886238
2023 Oncogenic SIRT7 inhibits GATA4 transcriptional activity and activates the Wnt signaling pathway in ovarian cancer. Gynecologic oncology 18 36804620
2017 Quantitative proteome-based systematic identification of SIRT7 substrates. Proteomics 18 28556401
2022 USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells. Breast cancer research and treatment 17 36040642
2024 SIRT7 knockdown promotes gemcitabine sensitivity of pancreatic cancer cell via upregulation of GLUT3 expression. Cancer letters 16 39002692
2022 CYP2E1-dependent upregulation of SIRT7 is response to alcohol mediated metastasis in hepatocellular carcinoma. Cancer gene therapy 16 35902730

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