Affinage

SEMA3E

Semaphorin-3E · UniProt O15041

Length
775 aa
Mass
89.2 kDa
Annotated
2026-06-10
35 papers in source corpus 19 papers cited in narrative 19 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SEMA3E is a secreted class 3 semaphorin guidance cue that signals through its high-affinity receptor PlexinD1 to control cell positioning, axon guidance, and vascular patterning across neural, immune, vascular, and skeletal tissues (PMID:19421194, PMID:21505259). In neurons, full-length Sema3E acts as a repellent through PlexinD1 to establish circuit specificity—dictating monosynaptic sensory-motor connectivity, laminar positioning of callosal neurons, and striatonigral projection routing—while co-expression of Neuropilin-1 with PlexinD1 gates this signaling, converting repulsion to attraction (PMID:18054858, PMID:19421194, PMID:31454665). The repulsive growth-cone collapse response is reinforced by an autoregulatory feedback loop in which Sema3E-PlexinD1 induces Mtss1 to aid PlexinD1 trafficking to the growth cone (PMID:38526535). SEMA3E also promotes maturing GnRH neuron survival via PLXND1-dependent PI3K signaling, and a Kallmann syndrome-associated point mutation, as well as a loss-of-function variant impairing secretion and neuronal binding, abrogates SEMA3E function in brain development (PMID:25985275, PMID:35628442). In the vasculature, Sema3E-PlexinD1 inhibits angiogenesis by activating RhoJ to suppress VEGF-induced endothelial filopodia—via release of the RhoGEF Tuba from PlexinD1—and by suppressing DLL4 through inhibition of Rac1/JNK signaling (PMID:21505259, PMID:30653356). In immune cells, Sema3E engages PlexinD1's intrinsic GAP activity to inhibit Rap1 activation, dampening LFA-1/integrin adhesion and immunological synapse formation to direct thymocyte positioning in the thymic medulla (PMID:24344262, PMID:26921307). A distinct pro-invasive output arises from furin-dependent cleavage of full-length Sema3E to a p61 isoform, which drives migration, invasion, and metastasis through PlexinD1-associated ErbB2 transactivation and a PI3K/ERK/Snail1 EMT program (PMID:16024618, PMID:20664171, PMID:21559368).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 2005 High

    Established that proteolytic processing functionally splits SEMA3E into opposing activities, explaining how a single repellent cue can also drive invasion.

    Evidence Furin-cleavage-deficient and truncated constructs with migration, invasion, ERK, and in vivo metastasis readouts in endothelial and pheochromocytoma cells

    PMID:16024618

    Open questions at the time
    • Receptor used by p61 not resolved in this study
    • Structural basis of the cleavage-dependent activity switch unknown
  2. 2007 High

    Defined PlexinD1 as the signaling receptor and showed Neuropilin-1 gates the sign of the response, converting repulsion to attraction.

    Evidence Sema3E-null mice, cell-type-specific expression profiling, and receptor domain-swap axon guidance assays in forebrain

    PMID:18054858

    Open questions at the time
    • Molecular mechanism by which Neuropilin-1 ectodomain switches signaling output not defined
    • Downstream effectors distinguishing attraction vs repulsion not identified
  3. 2009 High

    Demonstrated that Sema3E-PlexinD1 repulsion wires specific neural circuits, giving the cue a defined developmental purpose.

    Evidence Bidirectional conditional KO and ectopic expression in mice with retrograde tracing and electrophysiology of monosynaptic sensory-motor connections

    PMID:19421194

    Open questions at the time
    • Intracellular signaling effectors in sensory neurons not dissected
  4. 2010 High

    Identified the pro-invasive signaling mechanism as PlexinD1-associated ErbB2 transactivation in cancer cells.

    Evidence Reciprocal RNAi/overexpression in human carcinoma cells, transendothelial migration/invasion assays, mouse metastasis models, ErbB2 transactivation assay

    PMID:20664171

    Open questions at the time
    • Direct biochemical coupling of PlexinD1 to ErbB2 not structurally resolved
  5. 2011 High

    Resolved how Sema3E-PlexinD1 inhibits angiogenesis, linking the receptor to RhoJ-mediated suppression of VEGF-induced filopodia.

    Evidence Mouse retinal vascular development and oxygen-induced retinopathy models with RhoJ analysis and intravitreal Sema3E protein rescue

    PMID:21505259

    Open questions at the time
    • Link between PlexinD1 and RhoJ activation not biochemically defined at this stage
  6. 2011 Medium

    Connected Sema3E-PlexinD1 to an EMT program via PI3K/ERK-driven nuclear Snail1.

    Evidence RNAi knockdown of Sema3E/Plexin-D1/Snail1 with EMT marker blotting, Snail1 fractionation, and PI3K/ERK inhibitor experiments in ovarian cancer cells

    PMID:21559368

    Open questions at the time
    • Single lab
    • Relationship to furin-cleaved p61 isoform not addressed
  7. 2013 High

    Showed Sema3E/PlexinD1 controls integrin adhesion at the single-molecule level, regulating thymocyte movement.

    Evidence Single-molecule force spectroscopy of β1 integrin catch bonds, super-resolution imaging of nanoclusters, and PlexinD1 knockdown on thymocytes

    PMID:24344262

    Open questions at the time
    • Signaling intermediary between PlexinD1 and integrin bond lifetime not identified here
  8. 2015 High

    Established a pro-survival role via PLXND1/PI3K and linked SEMA3E to a human reproductive disorder through a function-abrogating mutation.

    Evidence Recombinant WT/mutant SEMA3E protein on GnRH neurons, PI3K inhibition, Sema3E/Plxnd1 KO mice, and exome sequencing of a Kallmann syndrome variant

    PMID:25985275

    Open questions at the time
    • How the same ligand-receptor pair triggers survival versus repulsion in different neurons not resolved
  9. 2016 High

    Defined the immune signaling mechanism as PlexinD1 GAP-mediated inhibition of Rap1, controlling adhesion and synapse formation.

    Evidence Rap1 activation assays, T-cell-specific Plexin D1 conditional KO, lipid bilayer immunological synapse assays, and two-photon imaging of thymic explants

    PMID:26921307

    Open questions at the time
    • Direct GAP substrate specificity within the Rap1 cascade not fully mapped
  10. 2019 High

    Resolved dual endothelial mechanisms of anti-angiogenic signaling—Rac1/JNK/DLL4 suppression and Tuba-release/RhoJ actin remodeling.

    Evidence Stroke model with PlexinD1-shRNA, brain microvascular endothelial cell assays, JNK/RhoJ readouts, and Tuba-PlexinD1 co-immunoprecipitation

    PMID:30653356

    Open questions at the time
    • Single co-IP for the Tuba-PlexinD1 interaction without reciprocal structural validation
  11. 2019 Medium

    Extended the guidance role to cranial neural crest migration and placed sema3E downstream of chd7.

    Evidence Morpholino knockdown and overexpression rescue in chd7 mutant zebrafish with time-lapse imaging of neural crest cells

    PMID:31464029

    Open questions at the time
    • Morpholino approach has off-target limitations
    • Receptor in neural crest not confirmed
  12. 2019 Medium

    Showed Sema3E/PlexinD1 controls laminar positioning of callosal projection neurons.

    Evidence Retrograde tracing and laminar quantification in Plxnd1 and Sema3e mutant mouse cortex

    PMID:31454665

    Open questions at the time
    • Single lab
    • Mechanism of positioning control not dissected
  13. 2021 Medium

    Established that post-stroke vascular remodeling depends on Sema3E-PlexinD1 restraining VEGF signaling to maintain BBB integrity.

    Evidence Plxnd1 conditional KO mice in brain infarction model with tracer extravasation, junctional protein imaging, and VEGF inhibitor rescue

    PMID:33978913

    Open questions at the time
    • Single lab
    • Direct molecular crosstalk between PlexinD1 and VEGF receptor not defined
  14. 2022 Medium

    Defined secretion and neuronal binding as functional requirements via a loss-of-function disease variant.

    Evidence In vitro secretion and embryonic neuronal/tissue binding assays of mutant vs WT SEMA3E with exome sequencing

    PMID:35628442

    Open questions at the time
    • In vitro readouts only
    • In vivo developmental consequence of the variant not tested
  15. 2024 High

    Revealed an autoregulatory feedback loop in which repulsive signaling induces Mtss1 to aid PlexinD1 trafficking and growth-cone collapse.

    Evidence Neurite outgrowth/collapse assays, Mtss1/Plxnd1/Sema3e KO mice with phenotypic convergence, and live-imaging trafficking assays in striatonigral neurons

    PMID:38526535

    Open questions at the time
    • Molecular basis of Mtss1-mediated PlexinD1 trafficking not fully defined
  16. 2025 Medium

    Placed Sema3e transcription under SETD2/H3K36me3 epigenetic control and SEMA3E upstream of AKT1 in odontoblast differentiation.

    Evidence Conditional Setd2 KO mice, H3K36me3 CUT&Tag, RNA-seq, and AKT1 activator (SC79) rescue

    PMID:40554768

    Open questions at the time
    • Receptor mediating SEMA3E-AKT1 coupling in odontoblasts not identified
    • Single lab
  17. 2026 Medium

    Extended SEMA3E function to metabolic tissue, driving beige adipocyte thermogenesis via Wnt/β-catenin.

    Evidence AAV knockdown in white adipose tissue in vivo, in vitro loss/gain-of-function, RNA-seq, mitochondrial respiration, and IWR-1 β-catenin inhibitor rescue

    PMID:41627586

    Open questions at the time
    • Receptor mediating adipocyte effect not defined
    • Single lab, novel context
  18. 2026 Medium

    Defined a PLEXIND1-SEMA3E/F axis in fetoplacental vascularization downstream of retinoic acid signaling.

    Evidence Raldh2-/- mouse embryos, single-cell RNA-seq, and all-trans-RA dietary rescue with vascular assays

    PMID:41884003

    Open questions at the time
    • SEMA3E vs SEMA3F contributions not disentangled
    • Single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single Sema3E-PlexinD1 axis selects among opposing outputs (repulsion vs attraction vs survival vs invasion) across cell types remains unresolved at the level of shared molecular switches.
  • No unifying structural model linking receptor context (Neuropilin-1, furin cleavage, GAP activity) to output selection
  • Cross-tissue comparison of effector usage lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 4 GO:0098772 molecular function regulator activity 2
Localization
GO:0005576 extracellular region 2
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-162582 Signal Transduction 3 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 2
Partners
ERBB2MTSS1NRP1PLXND1TUBA

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 Sema3E acts as a repellent on neurons expressing PlexinD1 alone, but the extracellular domain of Neuropilin-1 (co-expressed with PlexinD1) is sufficient to convert Sema3E/PlexinD1 repulsive signaling to attraction, defining a 'gating' function of neuropilins in semaphorin-plexin signaling during forebrain axon tract development. In vivo genetic analysis of Sema3E null mutant mice; neuron-specific expression profiling; axonal projection assays distinguishing PlexinD1-only vs PlexinD1+Neuropilin-1 neurons; behavioral testing Neuron High 18054858
2005 Full-length Sema3E is proteolytically processed by furin-dependent cleavage to generate a p61-Sema3E isoform; this truncated form is required and sufficient for pro-metastatic, pro-migratory, invasive-growth, and ERK1/2-activating activities in endothelial and pheochromocytoma cells, whereas full-length Sema3E acts as a repelling cue. In vitro migration and invasion assays; processing-deficient and truncated Sema3E constructs; ERK1/2 phosphorylation assays; in vivo lung metastasis model in mice; furin inhibitor experiments Cancer research High 16024618
2009 Sema3E expressed by specific motor neuron pools signals through its high-affinity receptor Plexin D1 on proprioceptive sensory neurons as a repellent cue to establish monosynaptic sensory-motor circuit specificity; altering Sema3E-Plxnd1 expression in either sensory or motor neurons causes functional and anatomical rewiring of monosynaptic connections. Molecular genetic manipulation in mice (conditional KO and ectopic expression of Sema3e and Plxnd1); retrograde tracing; electrophysiological recording of monosynaptic connections Nature High 19421194
2010 Sema3E signals through Plexin D1 in cancer cells to promote invasion and metastasis via transactivation of the Plexin D1-associated ErbB2/Neu oncogenic kinase; knockdown of either Sema3E or Plexin D1 impairs metastatic potential, while overexpression increases invasiveness, transendothelial migration, and metastatic spreading in mice. RNAi knockdown and overexpression in human metastatic carcinoma cells; transendothelial migration and invasion assays; mouse metastasis models; ErbB2 transactivation assay The Journal of clinical investigation High 20664171
2011 Sema3E binding to PlexinD1 in endothelial cells activates the small GTPase RhoJ, which counteracts VEGF-induced filopodia projections and defines retinal vascular pathfinding; intravitreal Sema3E protein selectively suppresses extraretinal vascular outgrowth in ischemic retinopathy. Mouse retinal vascular development assays; PlexinD1 and RhoJ expression analysis; VEGF signaling inhibition experiments; oxygen-induced retinopathy (OIR) model; intravitreal Sema3E protein administration The Journal of clinical investigation High 21505259
2011 Sema3E signals through Plexin-D1 to activate PI3K and ERK/MAPK, leading to nuclear localization of Snail1 and epithelial-to-mesenchymal transition (EMT) in ovarian endometrioid cancer cells; RNAi knockdown of Sema3E, Plexin-D1, or Snail1 reverses EMT and reduces cell motility. RNAi knockdown in cancer cells; Western blotting for EMT markers; nuclear/cytoplasmic fractionation for Snail1; PI3K and ERK inhibitor experiments; wound-healing and invasion assays PloS one Medium 21559368
2013 PlexinD1 controls nanometer-scale β1 integrin adhesion domain clustering in cis on developing thymocytes, while Sema3E ligation in trans shortens individual β1 integrin catch bond lifetimes under force; decreased PlexinD1 expression during developmental progression and thymic medulla Sema3E gradient together enhance thymocyte movement toward the medulla. Single-molecule force spectroscopy (catch bond measurements); super-resolution imaging of integrin nanoclusters; plexinD1 knockdown on thymocytes; flow chamber adhesion assays Proceedings of the National Academy of Sciences of the United States of America High 24344262
2015 Recombinant wild-type SEMA3E protects maturing GnRH neurons from apoptosis by triggering PLXND1-dependent activation of PI3K-mediated survival signaling; a Kallmann syndrome-associated point mutation in SEMA3E abrogates this neuroprotective activity; loss of either SEMA3E or PLXND1 in mice increases GnRH neuron apoptosis and reduces median eminence innervation. Exome sequencing; recombinant wild-type and mutant SEMA3E protein treatment of GnRH neurons; PI3K inhibitor experiments; Sema3E and Plxnd1 knockout mouse models; immunofluorescence counting of GnRH neuron apoptosis; median eminence innervation analysis The Journal of clinical investigation High 25985275
2016 Sema3E directly inhibits Rap1 activation and LFA-1-dependent adhesion in thymocytes through the GTPase-activating protein (GAP) activity of Plexin D1; this suppresses immunological synapse (IS) formation and Ag-scanning migration of thymocytes, promoting their positioning in the thymic medulla. Rap1 activation assays in thymocytes with sema3e treatment; T cell lineage-specific Plexin D1 conditional KO; supported lipid bilayer IS formation assay; two-photon live imaging of thymic explants/slices Journal of immunology High 26921307
2019 Sema3E/PlexinD1 signaling inhibits postischemic angiogenesis by: (1) suppressing DLL4 expression via inhibiting Rac1-induced JNK phosphorylation in brain microvascular endothelial cells; and (2) promoting F-actin disassembly and focal adhesion reduction by activating RhoJ through release of RhoGEF Tuba from direct binding to PlexinD1, causing endothelial filopodia retraction. In vivo stroke model (transient middle cerebral artery occlusion) with PlexinD1-shRNA; micro-optical sectioning tomography; cultured brain microvascular endothelial cells; JNK phosphorylation assays; RhoJ activation; co-immunoprecipitation of Tuba-PlexinD1; F-actin/focal adhesion imaging FASEB journal High 30653356
2021 Sema3E-Plexin-D1 signaling promotes post-stroke vascular remodeling and functional recovery by downregulating VEGF signaling; Plxnd1 knockout causes aberrantly increased VEGF signaling, abnormal vascular morphogenesis, and blood-brain barrier (BBB) impairment (junctional protein mislocalization), which are restored by VEGF signaling inhibition. Plxnd1 conditional KO mice; transient brain infarction model; neurological deficit scoring; infarct volume measurement; intravascular tracer extravasation; junctional protein immunofluorescence; VEGF pathway inhibitor rescue experiment Translational stroke research Medium 33978913
2024 Repulsive Sema3E-Plexin-D1 signaling induces expression of Mtss1 (metastasis suppressor 1) in striatonigral neurons as an autoregulatory feedback; Mtss1 localizes to the axonal side of neurites, promotes neurite outgrowth, and aids Plexin-D1 trafficking to the growth cone where it mediates collapse in response to Sema3E; Mtss1 KO mice exhibit fewer striatonigral projections and irregular axonal routes, phenocopying Plxnd1 and Sema3e KO mice. In vitro neurite outgrowth and growth cone collapse assays; Mtss1 KO mice; Plxnd1 and Sema3e KO mice; subcellular localization of Mtss1 by live imaging; Plexin-D1 trafficking assay; genetic epistasis (Mtss1 KO phenotype compared to Plxnd1/Sema3e KO) eLife High 38526535
2019 Knockdown of sema3E in zebrafish causes severe craniofacial malformations and impairs cranial neural crest cell migration (cells are misrouted/scattered in the hindbrain region); overexpression of sema3E rescues scattered cranial neural crest cells in chd7 homozygous mutants, placing sema3E downstream of chd7 in neural crest migration. Morpholino knockdown of sema3E in zebrafish; time-lapse imaging of sox10:EGFP neural crest cells; sema3E overexpression rescue in chd7 mutants; immunostaining of postmigratory neural crest cells International journal of experimental pathology Medium 31464029
2019 PlexinD1 and Sema3E signaling controls the laminar positioning of heterotopically projecting callosal neurons; Plxnd1 and Sema3e mutant mice exhibit ectopic neurons aberrantly located in layers 2/3 instead of their normal layer 5A position. Retrograde tracing of callosal projection neurons; immunofluorescence for PlexinD1 expression; Plxnd1 and Sema3e mutant mouse cortex analysis; laminar distribution quantification Molecular and cellular neurosciences Medium 31454665
2012 Recombinant Sema3e inhibits osteoblast migration (wound-healing assay) and decreases osteoclast formation by 81% in mouse bone marrow macrophage cultures, with concomitant downregulation of osteoclast differentiation markers (Itgb3, Acp5, Cd51, Nfatc1, CalcR, Ctsk); Sema3e receptor PlexinD1 is expressed on osteoblasts, macrophages, and osteoclasts. Recombinant Sema3e protein treatment; wound-healing migration assay; TRAP-positive osteoclast counting; qPCR for osteoclast markers; PlexinD1 expression analysis Calcified tissue international Medium 22227882
2022 A novel loss-of-function SEMA3E variant impairs protein secretion and hampers binding to embryonic mouse neuronal cells and tissues, establishing that secretion and neuronal cell binding are required for SEMA3E function in brain development. In vitro secretion assay of mutant vs wild-type SEMA3E; binding assay to embryonic mouse neuronal cells and brain tissue sections; exome sequencing International journal of molecular sciences Medium 35628442
2025 SETD2-mediated H3K36me3 at the Sema3e locus is required for Sema3e transcription in odontoblasts; SEMA3E (together with COL11A2) acts upstream of AKT1 signaling to promote odontoblastic differentiation, and AKT1 activator SC79 partially rescues impaired odontoblast differentiation caused by Setd2 deficiency. Conditional Setd2 knockout mouse models; spike-in CUT&Tag sequencing for H3K36me3 occupancy; RNA-seq; in vitro knockdown; AKT1 activator (SC79) rescue experiments Development Medium 40554768
2026 SEMA3E promotes beige adipocyte differentiation and thermogenesis via the Wnt/β-catenin pathway; SEMA3E knockdown delays β-catenin degradation and suppresses thermogenic gene expression, while inhibiting the Wnt/β-catenin pathway with IWR-1 rescues the suppressed differentiation caused by SEMA3E knockdown; SEMA3E knockdown also reduces mitochondrial respiration by downregulating respiratory chain component expression. AAV-mediated SEMA3E knockdown in inguinal white adipose tissue in vivo; loss- and gain-of-function in vitro; RNA-seq; mitochondrial oxygen consumption rate measurement; IWR-1 (β-catenin inhibitor) rescue; cold exposure and β-agonist models Apoptosis Medium 41627586
2026 A PLEXIND1-SEMA3E/F signaling axis between fetal endothelial cells and chorionic trophoblast precursors is required for fetoplacental vascularization; this axis is impaired in retinoic acid (RA)-deficient embryos and rescued by all-trans-RA administration, placing SEMA3E/PLEXIND1 downstream of RA signaling in placental vascular development. Raldh2-/- mouse embryos; single-cell RNA sequencing; ATRA rescue via maternal diet; functional vascular assays iScience Medium 41884003

Source papers

Stage 0 corpus · 35 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development. Neuron 196 18054858
2011 Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice. The Journal of clinical investigation 182 21505259
2010 Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice. The Journal of clinical investigation 154 20664171
2009 Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition. Nature 150 19421194
1998 Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines. Cancer research 133 9515811
2005 Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis. Cancer research 91 16024618
2015 Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome. The Journal of clinical investigation 83 25985275
2012 The role and mechanism-of-action of Sema3E and Plexin-D1 in vascular and neural development. Seminars in cell & developmental biology 80 23270617
2013 Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis. Proceedings of the National Academy of Sciences of the United States of America 65 24344262
2011 Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer. PloS one 56 21559368
2012 A class III semaphorin (Sema3e) inhibits mouse osteoblast migration and decreases osteoclast formation in vitro. Calcified tissue international 37 22227882
2016 Use of NRP1, a novel biomarker, along with VEGF-C, VEGFR-3, CCR7 and SEMA3E, to predict lymph node metastasis in squamous cell carcinoma of the tongue. Oncology reports 36 27666723
2018 Sema3E/PlexinD1 inhibition is a therapeutic strategy for improving cerebral perfusion and restoring functional loss after stroke in aged rats. Neurobiology of aging 33 30007159
2021 Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice. Translational stroke research 25 33978913
2013 Resolution of defective dorsal aortae patterning in Sema3E-deficient mice occurs via angiogenic remodeling. Developmental dynamics : an official publication of the American Association of Anatomists 23 23444297
2016 Sema3e/Plexin D1 Modulates Immunological Synapse and Migration of Thymocytes by Rap1 Inhibition. Journal of immunology (Baltimore, Md. : 1950) 20 26921307
2022 UHRF1 overexpression promotes osteosarcoma metastasis through altered exosome production and AMPK/SEMA3E suppression. Oncogenesis 19 36068209
2021 Mesenchymal Stromal Cells Promote Retinal Vascular Repair by Modulating Sema3E and IL-17A in a Model of Ischemic Retinopathy. Frontiers in cell and developmental biology 19 33553187
2019 Sema3E/PlexinD1 signaling inhibits postischemic angiogenesis by regulating endothelial DLL4 and filopodia formation in a rat model of ischemic stroke. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18 30653356
2022 PLXND1/SEMA3E Promotes Epithelial-Mesenchymal Transition Partly via the PI3K/AKT-Signaling Pathway and Induces Heterogenity in Colorectal Cancer. Annals of surgical oncology 16 35917012
2019 Sema3E is required for migration of cranial neural crest cells in zebrafish: Implications for the pathogenesis of CHARGE syndrome. International journal of experimental pathology 13 31464029
2022 A Novel Loss-of-Function SEMA3E Mutation in a Patient with Severe Intellectual Disability and Cognitive Regression. International journal of molecular sciences 10 35628442
2019 PlexinD1 and Sema3E determine laminar positioning of heterotopically projecting callosal neurons. Molecular and cellular neurosciences 10 31454665
2017 Association of Increased Serum Sema3E with TRIB3 Q84R Polymorphism and Carotid Atherosclerosis in Metabolic Syndrome. Annals of clinical and laboratory science 10 28249916
2013 To die or not to die: Sema3E rules the game. Cancer cell 9 24229706
2016 A SEMA3E mutant resistant to cleavage by furins (UNCL-SEMA3E) inhibits choroidal neovascularization. Experimental eye research 8 27725196
2024 Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1. eLife 5 38526535
2019 Identification of a novel heterozygous missense mutation of SEMA3E (c.1327G>A; p. Ala443Thr) in a labor induced fetus with CHARGE syndrome. Molecular genetics & genomic medicine 5 31691538
2007 Transferrin reverses the anti-invasive activity of human prostate cancer cells that overexpress sema3E. International journal of oncology 5 17912456
2025 Cardioprotective role of phoenixin-14 in isoproterenol-induced myocardial injury: Involvement of AMPK, JAK2/STAT3, and Sema3E pathways. Life sciences 3 40816502
2025 H3K36me3 modification by SETD2 is essential for Col11a2 and Sema3e transcription to maintain dentinogenesis in mice. Development (Cambridge, England) 2 40554768
2012 A case study on Sema3E-Fc aggregation and assay-dependent differences in quantitation. Bioanalysis 1 22452261
2026 SEMA3E promotes beige adipocyte differentiation and thermogenesis via β-catenin signaling in mice. Apoptosis : an international journal on programmed cell death 0 41627586
2026 Retinoic acid regulates fetoplacental vascularization via notch signaling and a SEMA3E/F-PLEXIND1 axis. iScience 0 41884003
2025 Bilateral Testicular Regression Syndrome and Optic Nerve Atrophy: Clinical Aspects of a Child with a <italic>SEMA3E</italic> Loss-of-Function Variant. Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 0 41243476

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