Affinage

SEC24C

Protein transport protein Sec24C · UniProt P53992

Length
1094 aa
Mass
118.3 kDa
Annotated
2026-06-10
25 papers in source corpus 20 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SEC24C is a cargo-selective adaptor subunit of the COPII vesicle coat that packages specific transmembrane cargo into vesicles at ER exit sites; it co-elutes and directly binds the SEC23 component of the inner coat (PMID:10214955). Through distinct cargo-binding pockets, SEC24C reads short ER-export motifs on client proteins: an RI motif whose +2 residue dictates SEC24C-versus-SEC24D selectivity in SLC6 neurotransmitter transporters such as SERT and the amino acid transporter SLC6A14/ATB0,+ (PMID:21454670, PMID:23288844, PMID:30445147), a triple-arginine (3R) motif in the α2B-adrenergic receptor (PMID:22404651), a ΦXΦXΦ motif engaged by the SEC24C IxM pocket (PMID:23658022), and a C-terminal YV motif in claudin-1 (PMID:28679754). The same IxM cargo-binding site captures the open-conformation Q-SNARE syntaxin5 together with GS27 and Bet1, coupling SNARE assembly to ER export (PMID:27413010). Beyond conventional anterograde transport, SEC24C is required for prechylomicron transport vesicle docking with the Golgi (PMID:19965600) and, acting with the p24 proteins TMP21 and TMED9, routes misfolded alpha-1-antitrypsin Z from the ER to lysosomes via ERLAD (PMID:38294851). Its activity is developmentally and physiologically essential: Sec24c-null mice die at E7.5, an early requirement attributable to expression timing rather than unique cargo specificity since SEC24D knock-in rescues both embryonic and neuronal phenotypes (PMID:24876386, PMID:34702932), yet postmitotic cortical neurons depend on SEC24C-mediated ER export for survival and for axonal targeting of cargoes such as SERT (PMID:24790205, PMID:29939162). SEC24C is regulated by cell-cycle-coupled O-GlcNAcylation and phosphorylation that govern its dispersal from ER exit sites during mitosis (PMID:40617351), and its FG-motif is bound at atomic resolution by the HIV-1 capsid lattice to support cytoplasmic core trafficking and infectivity (PMID:33649557).

Mechanistic history

Synthesis pass · year-by-year structured walk · 20 steps
  1. 1999 Medium

    Established SEC24C as a mammalian COPII inner-coat component by showing it partners with the SEC23 subunit and functions in ER export.

    Evidence Gel filtration co-elution and in vitro binding with Sec23p plus an overexpression ER-export defect assay

    PMID:10214955

    Open questions at the time
    • No cargo specificity defined
    • No structural basis of SEC23 binding
    • Endogenous function inferred only from overexpression
  2. 2009 High

    Extended SEC24C function beyond canonical vesicle formation to docking of a specialized lipid-cargo carrier with the Golgi.

    Evidence Immunodepletion of cytosolic SEC24C with recombinant protein rescue in a PCTV-Golgi docking assay

    PMID:19965600

    Open questions at the time
    • Molecular partner mediating docking not identified
    • Relationship to canonical COPII coating unclear
  3. 2011 High

    Demonstrated isoform-exclusive cargo selection by showing SERT requires SEC24C specifically, defining SEC24C as a dedicated ER-export adaptor for select cargoes.

    Evidence MS pulldown from brain lysates, isoform-selective siRNA, dominant-negative SEC24C, and cargo motif (RI) mutagenesis with surface biotinylation

    PMID:21454670

    Open questions at the time
    • Structural basis of motif recognition not resolved
    • Generality across cargo families not yet tested
  4. 2012 Medium

    Identified a distinct 3R recognition mode, showing SEC24C/D recognize multiple motif classes on diverse cargo including a GPCR.

    Evidence Co-IP, mutagenesis, and CD8 chimera transfer with surface expression for α2B-adrenergic receptor

    PMID:22404651

    Open questions at the time
    • SEC24C versus SEC24D contributions not separated
    • Direct binding pocket not mapped
  5. 2013 High

    Resolved how a single residue dictates SEC24C-versus-SEC24D isoform choice, giving a residue-level code for paralog selectivity.

    Evidence Isoform siRNA, dominant-negative constructs, and +2-position mutagenesis across SLC6 transporters with surface biotinylation

    PMID:23288844

    Open questions at the time
    • Structural explanation of +2 selectivity absent
    • In vivo consequences of switching not addressed
  6. 2013 High

    Mapped a SEC24C cargo-binding site (IxM) and a new ΦXΦXΦ motif, localizing motif recognition to a defined region of the adaptor.

    Evidence Peptide pulldown with Sec23A-Sec24C complex and SEC24C IxM-site (LIL→AAA) mutagenesis with chimeric cargo

    PMID:23658022

    Open questions at the time
    • No co-crystal of motif in the IxM pocket
    • Affinities and competition among motifs unquantified
  7. 2014 High

    Showed SEC24C-dependent ER export sets neuronal cargo polarity, linking adaptor selectivity to axonal targeting.

    Evidence Dominant-negative SEC24C/D and RI-motif mutagenesis with imaging of SERT distribution in primary dorsal raphe neurons

    PMID:24790205

    Open questions at the time
    • Mechanism connecting ER export to polarized sorting unresolved
    • Endogenous loss-of-function not tested here
  8. 2014 High

    Defined the organismal requirement for SEC24C, revealing essential embryonic function with tissue-restricted paralog compensation.

    Evidence Conventional and conditional Sec24c knockout mice with developmental phenotyping

    PMID:24876386

    Open questions at the time
    • Cargoes responsible for E7.5 lethality unknown
    • Basis of tissue-specific compensation not defined
  9. 2016 High

    Connected SEC24C to fusion-machinery export by showing it packages the assembled Q-SNARE complex via its IxM site.

    Evidence Co-IP, IxM-site mutagenesis, and immunoisolation of COPII vesicles with confocal co-localization

    PMID:27413010

    Open questions at the time
    • Conformational selectivity for open syntaxin5 not structurally explained
    • Coordination with R-SNARE-recruiting isoforms unclear
  10. 2017 Medium

    Showed a YV motif recruits SEC24C for claudin-1 surface delivery, with consequences for viral entry.

    Evidence Co-IP, YV-motif mutagenesis, surface expression, and HCV entry assay

    PMID:28679754

    Open questions at the time
    • Direct binding versus indirect association not distinguished
    • Single-lab functional readout
  11. 2018 High

    Established that postmitotic neurons uniquely depend on SEC24C, and that the dependency reflects shared adaptor activity rescuable by SEC24D.

    Evidence Conditional Sec24c KO mice, SEC24D knock-in rescue, iPSC-derived neuron knockdown, UPR and apoptosis assays

    PMID:29939162

    Open questions at the time
    • Neuron-essential cargoes not identified
    • Trigger of UPR upon SEC24C loss undefined
  12. 2021 High

    Provided atomic-resolution insight into a non-canonical role, showing HIV-1 capsid hijacks the SEC24C FG-motif for cytoplasmic core trafficking.

    Evidence 2.3-Å crystal structure, binding assays, SEC24C deletion/complementation, siRNA, and live-cell imaging of HIV-1 cores

    PMID:33649557

    Open questions at the time
    • How capsid binding intersects with normal COPII function unclear
    • Physiological ligand of the FG-motif unknown
  13. 2021 High

    Demonstrated paralog interchangeability in vivo, attributing the embryonic SEC24C requirement to expression timing rather than unique cargo specificity.

    Evidence C-terminal SEC24C→SEC24D knock-in mice with embryonic lethality rescue analysis

    PMID:34702932

    Open questions at the time
    • Cargo-specific differences in adult tissues not excluded
    • Mechanism of stage-specific expression not addressed
  14. 2021 Low

    Raised AKT-dependent phosphorylation as a regulatory input controlling SEC24C-mediated transporter export.

    Evidence 2D electrophoresis and phospho-PLA after AKT inhibition with SLC6A14 surface biotinylation

    PMID:34359969

    Open questions at the time
    • No direct kinase assay or phosphosite mutagenesis
    • Correlative link to transporter surface levels
  15. 2024 High

    Placed SEC24C in ERLAD-mediated quality control, routing misfolded ATZ to lysosomes via a p24-adaptor complex.

    Evidence Co-IP, live-cell imaging, siRNA depletion, chemical inhibitors, and p24 overexpression

    PMID:38294851

    Open questions at the time
    • Whether SEC24C acts through canonical COPII vesicles in ERLAD unclear
    • Selectivity for misfolded cargo undefined
  16. 2024 Low

    Proposed an ER-stress signaling role via PERK interaction and stress-induced relocalization promoting apoptosis.

    Evidence Co-IP, subcellular fractionation, and overexpression with drug-induced apoptosis in hepatocellular carcinoma cells

    PMID:39085101

    Open questions at the time
    • Single Co-IP without reciprocal validation
    • Nuclear localization claim conflicts with canonical ERES function and needs orthogonal confirmation
  17. 2025 Medium

    Revealed cell-cycle-coupled PTM control, with O-GlcNAcylation and phosphorylation timing SEC24C dispersal from ER exit sites during mitosis.

    Evidence Phosphoproteomics, O-GlcNAc analysis, cell-cycle synchronization, phosphosite mutagenesis, and live-cell imaging

    PMID:40617351

    Open questions at the time
    • Enzymes adding/removing the modifications not all defined
    • Functional impact on cargo export during mitosis not directly measured
  18. 2025 Low

    Linked SEC24C to a small-molecule-modulated innate-immunity step by weakening STING-SEC24C interaction to block ER-to-Golgi STING transport.

    Evidence Co-IP of STING and SEC24C with/without Tanshinone IIA and STING localization plus signaling readouts

    PMID:40252465

    Open questions at the time
    • No mutagenesis of the STING-SEC24C interface
    • Direct versus indirect interaction not resolved
  19. 2025 Low

    Implicated SEC24C as an effector in Kremen1-induced autophagic cell death through proximity to autophagy machinery.

    Evidence Biotin proximity labeling, autophagy effector silencing, pharmacological autophagy inhibition, and PLA

    PMID:41807954

    Open questions at the time
    • Correlative proximity without biochemical reconstitution
    • Direct SEC24C role versus bystander effect unresolved
  20. 2025 Medium

    Connected nutrient-sensing kinases to COPII reorganization, with AMPK/ULK1 driving SEC24C-dependent export of cargoes such as E-cadherin under glucose starvation.

    Evidence SEC24C KO cells, quantitative cell-surface proteomics, ULK1 kinase assay, and AMPK/ULK1 inhibition (preprint)

    Open questions at the time
    • Preprint not yet peer-reviewed
    • Direct SEC24C phosphorylation versus SEC31A-mediated effect not separated

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SEC24C integrates its many recognized motifs, PTMs, and stress signals into a unified set of structural and regulatory rules for cargo capture remains open.
  • No co-structure of a physiological cargo motif in the IxM/RI pockets
  • PTM regulation of cargo selectivity not directly demonstrated
  • Cargo basis of neuron- and embryo-essential functions unidentified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0038024 cargo receptor activity 6 GO:0060090 molecular adaptor activity 4
Localization
GO:0005783 endoplasmic reticulum 4 GO:0005829 cytosol 2 GO:0031410 cytoplasmic vesicle 2
Pathway
R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-9609507 Protein localization 3 R-HSA-392499 Metabolism of proteins 1
Partners
BET1EIF2AK3GS27SEC23ASLC6A4STX5TMED9TMP21
Complex memberships
COPII coatSec23-Sec24 inner coat

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 SEC24C (KIAA0079) is a mammalian homologue of yeast Sec24p: it co-elutes with mammalian Sec23p on gel filtration, its C-terminal region binds the N-terminal region of Sec23p in vitro, and overexpression causes a defect in protein export from the ER. Gel filtration co-elution, in vitro binding assay, overexpression ER-export assay FEBS letters Medium 10214955
2009 SEC24C is required for docking of the prechylomicron transport vesicle (PCTV) with the Golgi; immunodepletion of SEC24C from cytosol nearly completely abolished PCTV-Golgi docking activity, which was restored by adding back recombinant SEC24C. Immunodepletion of cytosolic SEC24C, reconstitution with recombinant SEC24C, PCTV-Golgi docking assay Journal of lipid research High 19965600
2011 SERT exclusively requires SEC24C (not SEC24A, B, or D) for ER export: mass spectrometry showed SERT C-terminal peptide recruits SEC24C-containing COPII complexes from brain lysates; siRNA depletion of SEC24C (but not other isoforms) trapped SERT in the ER; a dominant-negative SEC24C-D796V/D797N reduced SERT surface levels; and a SERT-607RI608-AA mutant lacking the SEC24C-binding motif was insensitive to SEC24C knockdown. Mass spectrometry pulldown from brain lysates, isoform-selective siRNA knockdown, dominant-negative SEC24C overexpression, surface biotinylation The Journal of biological chemistry High 21454670
2012 The triple Arg (3R) motif in the third intracellular loop of α2B-adrenergic receptor mediates direct interaction with Sec24C/D and is required for ER export; mutation or deletion of the 3R motif reduced co-immunoprecipitation with Sec24C/D and impaired cell surface transport. Co-immunoprecipitation, mutagenesis, surface expression assay, CD8 chimera transfer assay Traffic (Copenhagen, Denmark) Medium 22404651
2013 A single residue at position +2 downstream of the ER export motif (RI) in SERT determines SEC24C vs. SEC24D isoform specificity: hydrophilic residues (Lys, Asn, Gln) recruit SEC24C, whereas hydrophobic residues (Tyr, Val) recruit SEC24D. Substituting Lys610 with Tyr switched SERT from SEC24C- to SEC24D-dependence. siRNA depletion of individual SEC24 isoforms, dominant-negative SEC24C/D overexpression, mutagenesis of SERT and other SLC6 transporters, surface biotinylation The Journal of biological chemistry High 23288844
2013 A novel ER export signal motif ΦXΦXΦ (hydrophobic-X-hydrophobic-X-hydrophobic) in the N-terminus of bovine AE1 anion exchanger selectively interacts with SEC24C (via the Sec23A-Sec24C complex); mutation of the SEC24C IxM cargo-binding site (895LIL897→AAA) caused ER retention of ΦXΦXΦ-containing chimeric proteins. Synthetic peptide pulldown with Sec23A-Sec24C complex, chimeric protein mutagenesis, cell surface expression assay, N-glycan processing analysis, co-transfection with SEC24C-AAA dominant negative The Journal of biological chemistry High 23658022
2014 SEC24C-dependent ER export determines axonal targeting of SERT in dorsal raphe neurons: disruption of the SEC24C-binding motif (RI→AA) or overexpression of dominant-negative SEC24C-D796V/D797N redirected SERT from axons to the somatodendritic compartment, while VMAT2 axonal targeting was unaffected by either dominant-negative SEC24C or SEC24D. Dominant-negative SEC24C/D overexpression in cultured neurons, fluorescence imaging of endogenous and heterologous SERT distribution, mutagenesis The Journal of neuroscience High 24790205
2014 SEC24C is essential for early mammalian embryonic development; homozygous Sec24c null mice die at ~E7.5, whereas tissue-specific deletion in hepatocytes, pancreatic cells, smooth muscle cells, and intestinal epithelial cells produces no phenotype, indicating functional compensation by other SEC24 paralogs in those tissues. Conventional and conditional knockout mice, embryonic phenotype analysis The Journal of biological chemistry High 24876386
2016 SEC24C directly interacts with Syntaxin5 in its 'open' conformation and is required for ER export of the preassembled Q-SNARE complex (Syntaxin5, GS27, Bet1); mutation of the IxM cargo-binding site in SEC24C drastically reduced incorporation of all three Q-SNAREs into COPII vesicles, while R-SNARE Sec22b is recruited by other isoforms. Co-immunoprecipitation, dominant-negative/mutation of IxM site in SEC24C, immunoisolation of COPII vesicles, confocal co-localization Molecular biology of the cell High 27413010
2017 Claudin-1 interacts with SEC24C through its C-terminal YV motif for ER export and cell surface delivery; this interaction is required for HCV entry, as blocking COPII transport reduces claudin-1 surface levels. Co-immunoprecipitation, mutagenesis of YV motif, surface expression assay, HCV entry assay Journal of virology Medium 28679754
2018 SEC24C is essential for postmitotic neuron survival: conditional KO of Sec24c in neural progenitors caused perinatal mortality, microcephaly, unfolded protein response activation, and apoptosis of cortical neurons; this neuronal cell death was rescued by knock-in expression of SEC24D in place of SEC24C. Conditional Sec24c KO mice, SEC24D knock-in rescue, iPSC-derived neuron KD, UPR marker analysis, TUNEL apoptosis assay The Journal of clinical investigation High 29939162
2018 Amino acid transporter SLC6A14 (ATB0,+) exclusively co-precipitates with SEC24C (not with SEC24A, B, or D) for ER export; a dominant-negative SEC24C mutant reduced ATB0,+ plasma membrane expression and increased its proteolytic degradation; a Lys at position +2 of the RI export motif is required for SEC24C binding. Co-immunoprecipitation, proximity ligation assay, dominant-negative SEC24C, surface biotinylation, immunofluorescence co-localization Biochimica et biophysica acta. Molecular cell research Medium 30445147
2021 SEC24C is an HIV-1 host dependency factor: it directly and specifically interacts with hexameric HIV-1 capsid lattices via an FG-motif (residues 228-242); a 2.3-Å crystal structure showed the FG-motif binds a pocket comprising two adjoining capsid subunits; deletion of SEC24C reduced core stability, reverse transcription, nuclear import, and infectivity; live-cell microscopy showed SEC24C co-trafficked with HIV-1 cores in the cytoplasm during ingress. Crystal structure at 2.3-Å resolution, biochemical binding assays, Sec24C gene deletion and complementation in Jurkat cells, siRNA knockdown in HeLa cells, live-cell microscopy, reverse transcription and nuclear import assays Nature microbiology High 33649557
2021 AKT kinase phosphorylates SEC24C, and AKT inhibition decreases SEC24C phosphoserine levels (detected by proximity ligation assay and 2D electrophoresis), which correlates with transient increase of SLC6A14 transporter at the plasma membrane, suggesting AKT-mediated phosphorylation of SEC24C regulates ER export of SLC6A14. 2D electrophoresis, proximity ligation assay with phospho-specific antibodies, AKT inhibitor (MK-2206) treatment, surface biotinylation Cells Low 34359969
2021 Murine SEC24D can functionally substitute for SEC24C during embryonic development: Sec24cc-d/c-d knock-in mice (C-terminal 90% of SEC24C replaced by SEC24D sequence) survive to term whereas Sec24c null mice die at E7.5, indicating the early embryonic requirement for SEC24C reflects tissue/stage-specific expression rather than unique cargo specificity. Dual recombinase-mediated cassette exchange knock-in mice, embryonic lethality rescue analysis, pathological evaluation Scientific reports High 34702932
2024 SEC24C and p24-family members TMP21 and TMED9 facilitate clearance of misfolded alpha-1-antitrypsin Z (ATZ) from the ER to lysosomes via ERLAD: ATZ co-immunoprecipitates with TMP21, TMED9, SEC24C, FAM134B, and calnexin; live-cell imaging showed ATZ and p24-family members co-trafficking to lysosomes; depletion of SEC24C inhibited lysosomal trafficking of ATZ and increased intracellular ATZ levels; p24-family members co-immunoprecipitate with both ATZ and SEC24C, placing SEC24C at ER-exit sites for ERLAD. Co-immunoprecipitation, live-cell imaging, chemical inhibitors of ER exit/autophagy, siRNA depletion, overexpression of p24 proteins Molecular biology of the cell High 38294851
2024 SEC24C interacts with PERK (EIF2AK3) and activates downstream UPR-related apoptosis; under normal conditions SEC24C is nuclear-localized but translocates to the ER upon ER stress, and SEC24C overexpression augments bortezomib-induced apoptosis in hepatocellular carcinoma cells. Co-immunoprecipitation, subcellular fractionation/localization, overexpression + drug treatment apoptosis assay Bioscience trends Low 39085101
2025 SEC24C is dynamically regulated by O-GlcNAcylation (present in interphase) and phosphorylation (enriched in specific cell cycle phases); O-GlcNAc is rapidly removed upon mitotic entry and its removal influences the timing of SEC24C dispersal from juxtanuclear ER exit sites to a diffuse cytosolic pool; novel phosphosites were identified that regulate SEC24C stability and localization during mitosis. Mass spectrometry phosphoproteomics, O-GlcNAc modification analysis, cell cycle synchronization, live-cell imaging of SEC24C localization, mutagenesis of phosphosites The Journal of biological chemistry Medium 40617351
2025 Tanshinone IIA inhibits STING transport from the ER to the Golgi by weakening the interaction between STING and SEC24C, thereby preventing cGAS-STING pathway activation. Co-immunoprecipitation of STING and SEC24C with/without Tanshinone IIA, STING localization assay, downstream signaling readouts International immunopharmacology Low 40252465
2025 Kremen1 (dependence receptor) induces autophagic cell death requiring SEC24C: biotin proximity labeling identified SEC24C as a critical effector; Kremen1 is in proximity with SEC24C and ATG9A after vesicular trafficking, and SEC24C is brought into proximity with ATG8, ERGIC, and ATG9A, increasing autophagosome formation leading to cell death. Biotin proximity labeling (BioID/TurboID), genetic silencing of autophagy effectors, pharmacological inhibition of autophagy, proximity ligation assay Cell communication and signaling Low 41807954
2025 Acute glucose starvation impairs ER-to-Golgi export of specific cargoes (e.g., E-cadherin) in a SEC24C-dependent manner; AMPK and ULK1 signaling (independent of autophagy) orchestrate this process, with ULK1-mediated phosphorylation of SEC31A driving SEC24C-dependent COPII reorganization. SEC24C knockout cells, quantitative cell surface proteomics, nutrient deprivation experiments, ULK1 kinase assay, AMPK/ULK1 inhibitor experiments bioRxivpreprint Medium

Source papers

Stage 0 corpus · 25 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C. The Journal of biological chemistry 69 21454670
2021 Sec24C is an HIV-1 host dependency factor crucial for virus replication. Nature microbiology 66 33649557
2012 A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export. Traffic (Copenhagen, Denmark) 54 22404651
2013 Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C. The Journal of biological chemistry 46 23288844
2017 OLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages. Clinical proteomics 45 28344541
2018 The COPII cargo adapter SEC24C is essential for neuronal homeostasis. The Journal of clinical investigation 37 29939162
2014 Mammalian COPII coat component SEC24C is required for embryonic development in mice. The Journal of biological chemistry 34 24876386
2016 Sec24C/D-isoform-specific sorting of the preassembled ER-Golgi Q-SNARE complex. Molecular biology of the cell 31 27413010
2009 Sec24C is required for docking the prechylomicron transport vesicle with the Golgi. Journal of lipid research 28 19965600
2014 Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum. The Journal of neuroscience : the official journal of the Society for Neuroscience 27 24790205
2022 Sec24C mediates a Golgi-independent trafficking pathway that is required for tonoplast localisation of ABCC1 and ABCC2. The New phytologist 23 35510797
2013 A new class of endoplasmic reticulum export signal PhiXPhiXPhi for transmembrane proteins and its selective interaction with Sec24C. The Journal of biological chemistry 20 23658022
2017 Sec24C-Dependent Transport of Claudin-1 Regulates Hepatitis C Virus Entry. Journal of virology 19 28679754
2018 Trafficking of the amino acid transporter B0,+ (SLC6A14) to the plasma membrane involves an exclusive interaction with SEC24C for its exit from the endoplasmic reticulum. Biochimica et biophysica acta. Molecular cell research 17 30445147
2021 Murine SEC24D can substitute functionally for SEC24C during embryonic development. Scientific reports 10 34702932
1999 Hypothetical protein KIAA0079 is a mammalian homologue of yeast Sec24p. FEBS letters 10 10214955
2024 The p24-family and COPII subunit SEC24C facilitate the clearance of alpha1-antitrypsin Z from the endoplasmic reticulum to lysosomes. Molecular biology of the cell 8 38294851
2021 Ebola virus protein VP40 binding to Sec24c for transport to the plasma membrane. Proteins 8 34431571
2021 Trafficking to the Cell Surface of Amino Acid Transporter SLC6A14 Upregulated in Cancer Is Controlled by Phosphorylation of SEC24C Protein by AKT Kinase. Cells 6 34359969
2025 SEC24C deficiency causes trafficking and glycosylation abnormalities in an epileptic encephalopathy with cataracts and dyserythropoeisis. JCI insight 4 40131364
2024 SEC24C suppresses the propagation and chemoresistance of hepatocellular carcinoma by promoting unfolded protein response-related apoptosis. Bioscience trends 3 39085101
2025 Tanshinone IIA alleviates myocarditis in Trex1-D18N lupus-like mice by inhibiting the interaction between STING and SEC24C. International immunopharmacology 2 40252465
2025 Dynamic regulation of Sec24C by phosphorylation and O-GlcNAcylation during cell cycle progression. The Journal of biological chemistry 2 40617351
2024 Sec24C Participates in Cuticular Wax Transport by Facilitating Plasma Membrane Localization of ABCG5. Plant, cell & environment 2 39676447
2026 Kremen1 dependence receptor induces SEC24C and ATG9A-dependent cell death. Cell communication and signaling : CCS 0 41807954

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