Affinage

SBF2

Myotubularin-related protein 13 · UniProt Q86WG5

Length
1849 aa
Mass
208.5 kDa
Annotated
2026-06-10
61 papers in source corpus 14 papers cited in narrative 14 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SBF2 (MTMR13) is a large pseudophosphatase of the myotubularin family that coordinates phosphoinositide turnover with RAB-mediated endosomal trafficking (PMID:12687498, PMID:12554688, PMID:22648168). It physically associates with the active PI(3)P/PI(3,5)P2 phosphatase MTMR2 through coiled-coil sequences, forming a tetrameric complex that strongly enhances MTMR2 catalytic activity, and it stabilizes MTMR2 protein in vivo, where loss of MTMR13 reduces MTMR2 levels by roughly half (PMID:15998640, PMID:17855448, PMID:18349142). Through its DENN domain SBF2 acts as a guanine nucleotide exchange factor that activates RAB21, dynamically engaging class II PI 3-kinase and stably recruiting MTMR2 at PI(3)P-positive endosomes to couple lipid turnover with RAB21 activation (PMID:22648168). This activity is induced by starvation and drives RAB21-dependent endolysosomal trafficking of the SNARE VAMP8, required for autophagosome-lysosome fusion and starvation-induced autophagy (PMID:25648148), and it regulates EGFR sorting and downstream AKT signaling together with MTMR2 (PMID:19912440). In peripheral nerve, SBF2/MTMR2 function sustains Schwann cell myelination; loss-of-function mutations in SBF2 cause CMT4B2 demyelinating peripheral neuropathy with myelin outfoldings, a phenotype reproduced in Mtmr13-deficient mice and Schwann cell explants and partially rescued by MTMR2 overexpression (PMID:12687498, PMID:12554688, PMID:17855448, PMID:30419760).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2003 High

    Established SBF2/MTMR13 as a disease gene by linking loss-of-function mutations to CMT4B2, framing the protein as a myotubularin-family pseudophosphatase critical for myelin integrity.

    Evidence Homozygosity mapping and nonsense/exon-deletion mutation identification in consanguineous CMT4B2 families

    PMID:12554688 PMID:12687498

    Open questions at the time
    • Did not define the biochemical function of the pseudophosphatase domain
    • No molecular partner or pathway identified at this stage
  2. 2005 High

    Identified the physical basis of SBF2 function by showing endogenous association with the active phosphatase MTMR2 and membrane targeting via the pseudophosphatase domain.

    Evidence Endogenous Co-IP, subcellular fractionation, and domain-mapping fluorescence microscopy in HEK293 cells

    PMID:15998640

    Open questions at the time
    • Did not establish a functional consequence of the interaction for MTMR2 activity
    • Membrane identity not resolved
  3. 2007 High

    Showed the interaction is functionally consequential, with MTMR13 forming a tetrameric complex that enhances MTMR2 phosphatase activity, and reproduced CMT4B2 pathology in knockout mice.

    Evidence Mtmr13-deficient mice with nerve morphology and electrophysiology plus biochemical complex/activity assays

    PMID:17855448

    Open questions at the time
    • Did not address how enhanced phosphatase activity affects specific trafficking events
    • Stoichiometry of the complex in vivo not defined
  4. 2008 High

    Defined a stabilization mechanism by demonstrating that MTMR13 maintains MTMR2 protein levels in nerve, linking pseudophosphatase loss to reduced active phosphatase.

    Evidence Mtmr13-/- mice with nerve conduction velocity, electron microscopy, and western blotting of Mtmr2

    PMID:18349142

    Open questions at the time
    • Mechanism of stabilization (degradation pathway) not identified
    • Phosphoinositide substrate changes in vivo not measured
  5. 2011 Medium

    Connected the MTMR2/MTMR13 module to receptor trafficking by showing it regulates EGFR degradation and AKT signaling.

    Evidence Overexpression and mouse mutant analysis with EGFR and phospho-AKT western blotting

    PMID:19912440

    Open questions at the time
    • MTMR13-specific contribution mechanistically limited
    • Did not link EGFR sorting defect to myelin phenotype
  6. 2012 High

    Revealed the second enzymatic arm of SBF2 by demonstrating DENN-domain GEF activity toward RAB21, coupling PI(3)P turnover with RAB21 activation at endosomes.

    Evidence Drosophila macrophage genetics, epistasis, live imaging, PI(3)P reporters, and Rab21 GEF assay

    PMID:22648168

    Open questions at the time
    • GEF activity demonstrated in Drosophila ortholog; human RAB21 GEF assay not shown here
    • Structural basis of nucleotide exchange unresolved
  7. 2015 High

    Placed SBF2 GEF activity in autophagy by showing starvation-induced RAB21 activation drives VAMP8 endolysosomal trafficking required for autophagosome-lysosome fusion.

    Evidence RNAi in Drosophila and mammalian cells, GEF assays, MTMR13-VAMP8 Co-IP, VAMP8 trafficking imaging, autophagy flux

    PMID:25648148

    Open questions at the time
    • Direct vs indirect nature of the MTMR13-VAMP8 interaction not resolved
    • Relevance to Schwann cell pathology not tested
  8. 2018 Medium

    Tested causality of phosphatase loss for myelin pathology, showing MTMR2 overexpression partially rescues outfoldings while excluding VPS34 and PI3K-C2β as the relevant kinases in this context.

    Evidence Mtmr13-/- Schwann cell-DRG explants with MTMR2 overexpression and Mtmr13/Vps34 and Mtmr13/PI3K-C2β double knockouts

    PMID:30419760

    Open questions at the time
    • Only partial rescue indicates additional MTMR13 functions beyond MTMR2 stabilization
    • PI(3)P-generating kinase responsible for the phenotype not identified
  9. 2022 Medium

    Distinguished MTMR13 from the paralog MTMR5 within MTMR2 complexes, establishing partial redundancy and non-overlapping PNS roles.

    Evidence Mtmr5/Mtmr13 double knockout mice, western blotting, and nerve electron microscopy

    PMID:34718573

    Open questions at the time
    • Molecular basis of redundancy during embryogenesis not defined
    • Whether MTMR5 and MTMR13 form mutually exclusive complexes not directly shown
  10. 2022 Medium

    Extended SBF2 relevance to neuronal injury by showing it modulates taxane-induced damage in sensory neurons.

    Evidence SBF2 knockdown in iPSC-derived sensory neurons with viability, neurite outgrowth, and sodium current recordings

    PMID:34986146

    Open questions at the time
    • Molecular pathway linking SBF2 to sodium current and viability not defined
    • Connection to the MTMR2/RAB21 axis not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SBF2's dual roles as MTMR2-stabilizing pseudophosphatase and RAB21 GEF are integrated at endosomal membranes to control myelination, and the structural basis of these activities, remains unresolved.
  • No structural model of the SBF2-MTMR2 complex or DENN-RAB21 interface
  • Direct human RAB21 GEF kinetics not reported
  • Causal link between autophagy/VAMP8 trafficking defects and Schwann cell pathology untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005768 endosome 2 GO:0005829 cytosol 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 2 R-HSA-162582 Signal Transduction 1 R-HSA-9612973 Autophagy 1
Partners
MTMR2RAB21VAMP8
Complex memberships
MTMR2-MTMR13 tetrameric complex

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 SBF2 (MTMR13) was identified as a pseudophosphatase member of the myotubularin family; disease-causing nonsense mutations in MTMR13 were found in two consanguineous families with CMT4B2, establishing it as the causative gene for this demyelinating neuropathy with myelin outfoldings. Homozygosity mapping, mutation identification (nonsense mutations), genetic linkage to chromosome 11p15 American journal of human genetics High 12554688 12687498
2003 SBF2 encodes a large novel protein belonging to the pseudo-phosphatase branch of myotubularins; an in-frame deletion of SBF2 exons 11 and 12 disrupts an N-terminal domain conserved across species, establishing loss-of-function as the disease mechanism in CMT4B2. Homozygosity mapping, molecular analysis of SBF2 gene (exon deletion identified), expression analysis in peripheral nervous system tissues Human molecular genetics High 12554688
2005 Endogenous MTMR2 and MTMR13/SBF2 physically associate in human embryonic kidney 293 cells; this interaction is mediated by coiled-coil sequences present in each protein. MTMR13 is a predominantly membrane-associated protein, and its membrane association is mediated by the segment containing the pseudophosphatase domain. MTMR2 and MTMR13 co-fractionate in both a light membrane fraction and a cytosolic fraction. Co-immunoprecipitation of endogenous proteins, subcellular fractionation, fluorescence microscopy, deletion/domain mapping The Journal of biological chemistry High 15998640
2007 MTMR13/SBF2 forms a tetrameric complex with MTMR2, and this interaction strongly increases the enzymatic phosphatase activity of MTMR2 (which dephosphorylates PtdIns 3-phosphate and PtdIns 3,5-bisphosphate). Mtmr13/Sbf2-deficient mice develop myelin outfoldings and infoldings with decreased motor performance, reproducing CMT4B2 pathological hallmarks. Generation of Mtmr13/Sbf2-deficient mice, nerve morphology, electrophysiology, biochemical characterization of protein complex and enzymatic activity Human molecular genetics High 17855448
2008 Loss of Mtmr13 in mice leads to a peripheral neuropathy with myelin outfoldings and infoldings predominantly at the paranode, reduced nerve conduction velocity, and axon loss. Mtmr2 protein levels are decreased by approximately 50% in Mtmr13-deficient sciatic nerves, indicating that Mtmr13 stabilizes Mtmr2. Knockout mouse model (Mtmr13-/- mice), nerve conduction velocity measurements, electron microscopy, western blotting for Mtmr2 levels Proceedings of the National Academy of Sciences of the United States of America High 18349142
2011 Overexpression of Mtmr2 prevents degradation of the epidermal growth factor receptor (EGFR) and leads to sustained Akt activation. Mtmr13/Sbf2 counteracts the blockage of EGFR degradation (without affecting prolonged Akt activation), indicating that MTMR2 and MTMR13/SBF2 regulate EGFR sorting and downstream AKT signaling. Overexpression in cell lines, western blotting for EGFR and phospho-AKT, signaling pathway analysis in Mtmr2 and Mtmr13/Sbf2 mouse mutants Journal of cellular and molecular medicine Medium 19912440
2012 Drosophila Sbf (ortholog of MTMR13) functions as a guanine nucleotide exchange factor (GEF) that activates Rab21 GTPase. Sbf coordinates PI(3)P turnover (by dynamically interacting with class II PI 3-kinase and stably recruiting Mtm/MTMR2) and Rab21 activation at PI(3)P endosomes. Together, Sbf, Mtm, and Rab21 control macrophage protrusion formation through an endosomal trafficking pathway. Genetic knockdown in Drosophila macrophages, epistasis analysis, live imaging, PI(3)P reporter assays, GEF activity assay for Rab21 Molecular biology of the cell High 22648168
2015 Starvation induces Sbf/MTMR13 GEF activity and RAB21 activation. MTMR13 is required for RAB21 activation, VAMP8 interaction, and VAMP8 endolysosomal trafficking; depletion of Sbf/MTMR13 or Rab21 blocks endolysosomal trafficking of VAMP8 (a SNARE required for autophagosome-lysosome fusion), thereby blocking starvation-induced autophagy. RNAi knockdown in Drosophila and mammalian cells, GEF activity assays, co-immunoprecipitation (MTMR13-VAMP8 interaction), fluorescence microscopy of VAMP8 trafficking, autophagy flux assays EMBO reports High 25648148
2013 A missense mutation (c.659C>G, p.Thr220Arg) in the DENN domain of SBF2 was identified in patients with severe thrombocytopenia, suggesting the DENN domain mediates putative association with Rab GTPases important for vesicle transport and membrane trafficking. Whole-exome sequencing, Sanger sequencing validation, family segregation analysis Journal of thrombosis and thrombolysis Low 23334996
2018 In an in vitro SC-DRG explant model of CMT4B2, Mtmr13-/- Schwann cells develop myelin outfoldings, and Mtmr13 deficiency reduces Mtmr2 levels, further supporting Mtmr13's role in stabilizing Mtmr2. Overexpression of MTMR2 in Mtmr13-/- SC-DRGs moderately reduced myelin outfoldings, indicating that reduced PI 3-phosphatase activity contributes to the phenotype. Loss of vacuolar protein sorting 34 (Vps34) or PI3K-C2β in Mtmr13-/- mice had no impact on myelin outfoldings. Schwann cell-DRG explant culture from Mtmr13-/- mice, MTMR2 overexpression, double knockout mice (Mtmr13-/- x Vps34-/- and Mtmr13-/- x PI3K-C2β-/-), electron microscopy ASN neuro Medium 30419760
2022 Mtmr2 is required to maintain wild-type levels of both Mtmr5 and Mtmr13 in mouse peripheral nerves, suggesting these factors function in discrete protein complexes with Mtmr2. Genetic elimination of both Mtmr5 and Mtmr13 in mice leads to perinatal lethality, indicating partial functional redundancy during embryogenesis. Loss of Mtmr5 causes axon radial sorting defects without CMT4B2-like myelin outfoldings, distinguishing the roles of Mtmr5 and Mtmr13 in the PNS. Double knockout mice (Mtmr5-/- x Mtmr13-/-), western blotting for protein levels, nerve morphology by electron microscopy, quantification of myelinated axons Human molecular genetics Medium 34718573
2006 Overexpressed epitope-tagged Sbf2 shows cytoplasmic distribution in cells. Sbf2 mRNA is broadly expressed across tissues including peripheral nervous system, and the murine Sbf2 protein shares high amino acid identity with human SBF2. Overexpression of epitope-tagged protein with fluorescence microscopy, in situ hybridization, Northern blot, RT-PCR Gene expression patterns : GEP Low 16750429
2015 siRNA-mediated silencing of SBF2 in pancreatic cancer PANC-1 cells inhibited proliferation and promoted apoptosis, accompanied by decreased phospho-SMAD-2 and phospho-SMAD-3 and increased SMAD-7, suggesting SBF2 modulates TGF-β/SMAD signaling. siRNA knockdown, MTT proliferation assay, flow cytometry apoptosis assay, western blotting for TGF-β/SMAD pathway components Technology in cancer research & treatment Low 25882882
2022 SBF2 knockdown in iPSC-derived sensory neurons exacerbated paclitaxel-induced changes to cell viability and neurite outgrowth while attenuating paclitaxel-induced sodium current inhibition, providing functional evidence that SBF2 modulates taxane-induced neuronal damage. Ex vivo model: SBF2 knockdown in iPSC-derived sensory neurons, cell viability assays, neurite outgrowth measurement, electrophysiology (sodium current recording), gene expression analysis PLoS genetics Medium 34986146

Source papers

Stage 0 corpus · 61 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Mutations in MTMR13, a new pseudophosphatase homologue of MTMR2 and Sbf1, in two families with an autosomal recessive demyelinating form of Charcot-Marie-Tooth disease associated with early-onset glaucoma. American journal of human genetics 232 12687498
2019 Exosomal transfer of long non-coding RNA SBF2-AS1 enhances chemoresistance to temozolomide in glioblastoma. Journal of experimental & clinical cancer research : CR 224 30992025
2003 Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15. Human molecular genetics 205 12554688
2020 Down-regulated lncRNA SBF2-AS1 in M2 macrophage-derived exosomes elevates miR-122-5p to restrict XIAP, thereby limiting pancreatic cancer development. Journal of cellular and molecular medicine 112 32301277
2005 The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease. The Journal of biological chemistry 95 15998640
2015 Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion. EMBO reports 76 25648148
2016 High expression of long non-coding RNA SBF2-AS1 promotes proliferation in non-small cell lung cancer. Journal of experimental & clinical cancer research : CR 73 27154193
2019 LncRNA SBF2-AS1 promotes the progression of cervical cancer by regulating miR-361-5p/FOXM1 axis. Artificial cells, nanomedicine, and biotechnology 62 30856345
2012 Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. Molecular biology of the cell 61 22648168
2017 Transcription Factor NFAT5 Promotes Glioblastoma Cell-driven Angiogenesis via SBF2-AS1/miR-338-3p-Mediated EGFL7 Expression Change. Frontiers in molecular neuroscience 60 28983240
2008 Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice. Proceedings of the National Academy of Sciences of the United States of America 60 18349142
2019 Long Noncoding RNA SBF2-AS1 Is Critical for Tumorigenesis of Early-Stage Lung Adenocarcinoma. Molecular therapy. Nucleic acids 57 31071530
2020 LncRNA SBF2-AS1 affects the radiosensitivity of non-small cell lung cancer via modulating microRNA-302a/MBNL3 axis. Cell cycle (Georgetown, Tex.) 55 31928130
2019 Long noncoding RNA SBF2-AS1 act as a ceRNA to modulate cell proliferation via binding with miR-188-5p in acute myeloid leukemia. Artificial cells, nanomedicine, and biotechnology 52 31062614
2019 Long non-coding SBF2-AS1 acting as a competing endogenous RNA to sponge microRNA-142-3p to participate in gemcitabine resistance in pancreatic cancer via upregulating TWF1. Aging 48 31619579
2007 Mtmr13/Sbf2-deficient mice: an animal model for CMT4B2. Human molecular genetics 48 17855448
2018 Long non-coding RNA SBF2-AS1 promotes hepatocellular carcinoma progression through regulation of miR-140-5p-TGFBR1 pathway. Biochemical and biophysical research communications 44 30115383
2019 Long noncoding RNA SBF2-AS1 promotes colorectal cancer proliferation and invasion by inhibiting miR-619-5p activity and facilitating HDAC3 expression. Journal of cellular physiology 42 30912164
2020 Down-regulated lncRNA SBF2-AS1 inhibits tumorigenesis and progression of breast cancer by sponging microRNA-143 and repressing RRS1. Journal of experimental & clinical cancer research : CR 38 31952549
2016 Charcot-Marie-Tooth gene, SBF2, associated with taxane-induced peripheral neuropathy in African Americans. Oncotarget 36 27732968
2004 SET binding factor 2 (SBF2) mutation causes CMT4B with juvenile onset glaucoma. Neurology 34 15304601
2018 Upregulated long non-coding RNA SBF2-AS1 promotes proliferation in esophageal squamous cell carcinoma. Oncology letters 29 29552140
2011 The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signalling. Journal of cellular and molecular medicine 28 19912440
2008 Genome-wide association study identifies two novel loci containing FLNB and SBF2 genes underlying stature variation. Human molecular genetics 24 19039035
2020 Downregulation of SBF2-AS1 functions as a tumor suppressor in clear cell renal cell carcinoma by inhibiting miR-338-3p-targeted ETS1. Cancer gene therapy 22 32719443
2019 SBF2-AS1: An oncogenic lncRNA in small-cell lung cancer. Journal of cellular biochemistry 19 31050364
2023 YBX1/lncRNA SBF2-AS1 interaction regulates proliferation and tamoxifen sensitivity via PI3K/AKT/MTOR signaling in breast cancer cells. Molecular biology reports 18 36754932
2021 Emerging roles of a pivotal lncRNA SBF2-AS1 in cancers. Cancer cell international 16 34372871
2020 E2F1-Induced Overexpression of Long Noncoding RNA SBF2-AS1 Promotes Non-Small-Cell Lung Cancer Metastasis Through Regulating miR-362-3p/GRB2 Axis. DNA and cell biology 16 32364763
2020 Long noncoding RNA SBF2-AS1 contributes to the growth and metastatic phenotypes of NSCLC via regulating miR-338-3p/ADAM17 axis. Aging 16 32976115
2019 Silencing of long noncoding RNA SBF2-AS1 inhibits proliferation, migration and invasion and contributes to apoptosis in osteosarcoma cells by upregulating microRNA-30a to suppress FOXA1 expression. Cell cycle (Georgetown, Tex.) 15 31432728
2021 Downregulation of lncRNA SBF2-AS1 inhibits hepatocellular carcinoma proliferation and migration by regulating the miR-361-5p/TGF-β1 signaling pathway. Aging 13 34341185
2013 Identification of a novel SBF2 missense mutation associated with a rare case of thrombocytopenia using whole-exome sequencing. Journal of thrombosis and thrombolysis 12 23334996
2022 LncRNA SBF2-AS1: A Budding Star in Various Cancers. Current pharmaceutical design 11 35440300
2021 The molecular mechanisms of the long noncoding RNA SBF2-AS1 in regulating the proliferation of oesophageal squamous cell carcinoma. Scientific reports 11 33436941
2021 LncRNA SBF2-AS1 Promotes Diffuse Large B-Cell Lymphoma Growth by Regulating FGFR2 via Sponging miR-494-3p. Cancer management and research 11 33519236
2021 Low expression of lncRNA SBF2-AS1 regulates the miR-302b-3p/TGFBR2 axis, promoting metastasis in laryngeal cancer. Molecular carcinogenesis 11 34644425
2022 Distinct roles for the Charcot-Marie-Tooth disease-causing endosomal regulators Mtmr5 and Mtmr13 in axon radial sorting and Schwann cell myelination. Human molecular genetics 10 34718573
2022 The impact of SBF2 on taxane-induced peripheral neuropathy. PLoS genetics 9 34986146
2019 The Long Non-Coding RNA SBF2-AS1 Exerts Oncogenic Functions In Gastric Cancer By Targeting The miR-302b-3p/E2F Transcription Factor 3 Axis. OncoTargets and therapy 9 31802900
2021 Silencing of SBF2-AS1 inhibits cell growth and invasion by sponging microRNA-338-3p in serous ovarian carcinoma. The Kaohsiung journal of medical sciences 8 34850542
2018 Novel SBF2 mutations and clinical spectrum of Charcot-Marie-Tooth neuropathy type 4B2. Clinical genetics 8 30028002
2022 Long Noncoding RNA SBF2-AS1 Promotes Abdominal Aortic Aneurysm Formation through the miRNA-520f-3p/SMARCD1 Axis. Disease markers 6 35968497
2018 An In Vitro Model of Charcot-Marie-Tooth Disease Type 4B2 Provides Insight Into the Roles of MTMR13 and MTMR2 in Schwann Cell Myelination. ASN neuro 6 30419760
2014 Identification of a novel SBF2 frameshift mutation in charcot-marie-tooth disease type 4B2 using whole-exome sequencing. Genomics, proteomics & bioinformatics 6 25462154
2020 Correction to: Down-regulated lncRNA SBF2-AS1 inhibits tumorigenesis and progression of breast cancer by sponging microRNA-143 and repressing RRS1. Journal of experimental & clinical cancer research : CR 5 32264934
2020 LncRNA SBF2-AS1 inhibits apoptosis and promotes proliferation in lung cancer cell via regulating FOXM1. Journal of B.U.ON. : official journal of the Balkan Union of Oncology 5 33099911
2019 Charcot-Marie-Tooth type 4B2 demyelinating neuropathy in miniature Schnauzer dogs caused by a novel splicing SBF2 (MTMR13) genetic variant: a new spontaneous clinical model. PeerJ 5 31772832
2014 Charcot-Marie-Tooth 4B2 caused by a novel mutation in the MTMR13/SBF2 gene in two related Portuguese families. Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 4 25873783
2023 Knocking down of lncRNA SBF2-AS1 inhibits proliferation, invasion and induces apoptosis of colorectal cancer through regulating PTEN. Cellular and molecular biology (Noisy-le-Grand, France) 3 38279439
2022 LncRNA SBF2-AS1 Facilitates Nonsmall Cell Lung Cancer Progression by Targeting miR-520a-3p. Journal of healthcare engineering 3 35444785
2006 Cloning, expression and characterization of the murine orthologue of SBF2, the gene mutated in Charcot-Marie-Tooth disease type 4B2. Gene expression patterns : GEP 3 16750429
2024 Oncogenic role of lncRNA SBF2-AS1 in bladder cancer. Gene 2 39486664
2022 Knockdown of LncRNA SBF2-AS1 Inhibited Gastric Cancer Tumorigenesis via the Wnt/LRP5 Signaling Pathway. Acta medica Okayama 2 36549764
2015 siRNA-Mediated SBF2 Silencing May Inhibit Pancreatic Cancer Cells via Attenuation of the TGF-β Signaling Pathway. Technology in cancer research & treatment 2 25882882
2020 The Long Non-Coding RNA SBF2-AS1 Exerts Oncogenic Functions in Gastric Cancer by Targeting the miR-302b-3p/E2F Transcription Factor 3 Axis [Retraction]. OncoTargets and therapy 1 32280237
2026 LncRNA SBF2-AS1 Regulates Pyroptosis to Promote Chlamydia trachomatis Growth Through miR-196b-5p/RIPK2 Axis. Microorganisms 0 41753745
2024 Knockdown of long non-coding RNA SBF2-AS1 inhibits calcium oxalate-induced HK-2 cell injury by regulating the miR-302e/NLRP3 pathway. Urolithiasis 0 39105900
2023 SBF2-AS1 and TreRNA: novel lncRNA players in triple-negative breast cancer pathogenesis. Molecular biology reports 0 37286777
2023 Retracted: Long Noncoding RNA SBF2-AS1 Promotes Abdominal Aortic Aneurysm Formation through the miRNA-520f-3p/SMARCD1 Axis. Disease markers 0 37538086
2023 Retracted: LncRNA SBF2-AS1 Facilitates Nonsmall Cell Lung Cancer Progression by Targeting miR-520a-3p. Journal of healthcare engineering 0 37593490

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