Affinage

ROMO1

Reactive oxygen species modulator 1 · UniProt P60602

Length
79 aa
Mass
8.2 kDa
Annotated
2026-06-10
50 papers in source corpus 24 papers cited in narrative 26 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ROMO1 is a nuclear-encoded inner mitochondrial membrane protein that couples mitochondrial reactive oxygen species (ROS) output to cell proliferation, apoptosis, senescence, and mitochondrial architecture (PMID:16842742, PMID:18836179, PMID:24473195). It forms a nonselective cation channel through an amphipathic helical transmembrane domain, structurally resembling class II viroporins and inhibited by Fe2+ ions (PMID:29545371). ROMO1 generates ROS through electron transport chain complex III and is required for ROS-dependent cellular outcomes including normal proliferation via the ERK pathway, G1-to-S transition, replicative senescence, and oxidative-stress-induced apoptosis (PMID:23867822, PMID:18313394, PMID:19513905, PMID:18836179). As an essential regulator of mitochondrial dynamics, ROMO1 supports OPA1 oligomerization to maintain cristae junction integrity and mitochondrial fusion, with its loss causing mitochondrial fragmentation, cristae collapse, and impaired respiration (PMID:24473195). ROMO1 is a constituent of the human TIM23 presequence translocase specifically required for import of the inner-membrane protease YME1L, whose loss in ROMO1-null cells causes aberrant OPA1 processing (PMID:30598479). Beyond intrinsic mitochondrial functions, ROMO1 serves as a molecular bridge transmitting extramitochondrial signals to mitochondrial ROS: TNF-alpha via TNF complex II (PMID:20203691), MYC in a ROS-dependent negative-feedback loop (PMID:21558421), and TRAF2 deficiency or PKLR/MYCN inputs that drive senescence and neuroendocrine differentiation (PMID:38043870, PMID:36963289), with downstream effects on NF-κB activation and tumor cell invasion (PMID:25044121, PMID:25673177). In vivo, ROMO1 is essential for embryonic development, supports pancreatic beta-cell spare respiratory capacity through complex II/succinate dehydrogenase, protects the mitochondrial cysteinome to sustain energy metabolism and limit the permeability transition, and maintains motor neuron integrity (PMID:41995846, PMID:40461459).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2006 Medium

    Establishing that an uncharacterized mitochondrial protein could actively raise cellular ROS defined ROMO1 as a candidate ROS modulator rather than a passive bystander.

    Evidence Subcellular fractionation plus overexpression with ROS measurement

    PMID:16842742

    Open questions at the time
    • No molecular mechanism for ROS generation identified
    • Source within mitochondria not localized
  2. 2008 Medium

    Linking ROMO1-derived ROS to proliferation and senescence showed the protein's ROS output is a physiological signal, not merely a damaging byproduct.

    Evidence siRNA knockdown and overexpression with ERK-pathway and senescence/DNA-damage readouts, H2O2 rescue

    PMID:18313394 PMID:18836179

    Open questions at the time
    • Mechanism connecting ROMO1 to ERK not resolved
    • ROS-generating machinery not yet pinpointed
  3. 2009 Medium

    Demonstrating ROMO1-ROS requirement for G1-to-S transition placed the protein within cell-cycle control via p27(Kip1).

    Evidence siRNA knockdown, flow cytometry, p27 western blot, ROS measurement in fibroblasts

    PMID:19513905

    Open questions at the time
    • Direct molecular link from ROS to p27 regulation not defined
  4. 2010 Medium

    Identifying TNF complex II binding to the ROMO1 C-terminus established ROMO1 as a bridge translating extramitochondrial death signals into mitochondrial ROS and apoptosis.

    Evidence Co-IP, domain mapping, siRNA knockdown with ROS and apoptosis readouts; serum-deprivation ROS/apoptosis assays

    PMID:19904609 PMID:20203691

    Open questions at the time
    • BCL-XL recruitment mechanism partially defined
    • Channel basis of ROS production unknown at this stage
  5. 2011 Medium

    Placing ROMO1 in a MYC negative-feedback loop and downstream of BCL-XL refined how proliferative and survival signals are tuned by its ROS output.

    Evidence Overexpression, knockdown, ubiquitylation assays, epistasis with BCL-XL

    PMID:21399876 PMID:21558421

    Open questions at the time
    • BCL-XL finding is single-approach overexpression
    • Directness of ROS effect on SKP2/MYC ubiquitylation not biochemically isolated
  6. 2013 Medium

    Assigning ROMO1-dependent ROS to complex III gave a specific source within the electron transport chain for its oxidative output.

    Evidence siRNA knockdown with complex III identification, ROS and cell death assays in lung epithelial cells

    PMID:23867822

    Open questions at the time
    • Whether ROMO1 acts on complex III directly or indirectly not resolved
  7. 2014 High

    Identifying ROMO1 as essential for OPA1 oligomerization and cristae integrity reframed it as a core regulator of mitochondrial dynamics, and linking it to NF-κB extended its signaling reach.

    Evidence Genome-wide RNAi screen, native PAGE for OPA1 oligomers, EM of cristae, respiration assays; NF-κB reporter and IκBα phosphorylation assays

    PMID:24473195 PMID:25044121

    Open questions at the time
    • Molecular mechanism by which ROMO1 promotes OPA1 oligomerization not defined
    • Link between ROMO1 ROS and constitutive IκBα phosphorylation indirect
  8. 2018 High

    Reconstituting channel activity and defining ROMO1 as a TIM23 translocase constituent required for YME1L import provided two distinct biochemical activities and connected ROMO1 to OPA1 processing.

    Evidence Electrophysiology, TMD mutagenesis, structural modeling, Fe2+ inhibition; mass spectrometry of TIM23 complex, KO cells, import and OPA1-processing assays

    PMID:29545371 PMID:30598479

    Open questions at the time
    • Relationship between channel activity and translocase function unresolved
    • How ROMO1 selects YME1L over other substrates not defined
  9. 2020 Medium

    Extending ROMO1 to immune and cancer contexts (macrophage polarization, BAX/Parkin-dependent TRAIL sensitization, NET formation) showed its ROS output shapes diverse cell-fate programs.

    Evidence Overexpression and knockdown with mTORC1, BAX-Parkin Co-IP, NET and apoptosis assays; xenograft/in vivo models

    PMID:30850160 PMID:31945745 PMID:32825500

    Open questions at the time
    • mTORC1 polarization finding is low-confidence with limited mechanism
    • Directness of ROMO1 effects on each effector not isolated
  10. 2023 Medium

    Defining TRAF2- and PKLR/MYCN-driven ROMO1 induction connected upstream transcriptional inputs to ROMO1-dependent senescence and neuroendocrine differentiation.

    Evidence TRAF2 KO with NAD+/SIRT3/SOD2 pathway analysis; nuclear fractionation and Co-IP for PKLR-MYCN/MAX with NE differentiation markers

    PMID:36963289 PMID:38043870

    Open questions at the time
    • Whether ROMO1 induction is the sole driver of these phenotypes not established
  11. 2025 High

    Showing ROMO1 protects the mitochondrial cysteinome reframed it as a guardian of proteinaceous thiols supporting energy metabolism, Ca2+ uniport, and resistance to permeability transition, with anti-aging effects in vivo.

    Evidence Redox proteomics, overexpression in cells and aged mice, respiration, Ca2+ uniport and mPTP assays

    PMID:40461459

    Open questions at the time
    • Mechanism by which ROMO1 channel/redox activity drives cysteinome reduction not defined
  12. 2026 High

    In vivo knockout studies established ROMO1 as essential for embryogenesis, beta-cell respiratory capacity at complex II/SDH, and tissue contexts including airway mucus and radiation injury, demonstrating organismal-level requirement.

    Evidence Whole-body and conditional KO mice, human islet KO, Seahorse respirometry, glucose-stimulated insulin secretion; airway epithelial knockdown with STAT6/MUC5AC readouts; skin-specific KO with wound-healing scoring

    PMID:41673839 PMID:41995846 PMID:42021879

    Open questions at the time
    • How ROMO1 loss specifically reduces complex II/SDH activity not mechanistically resolved
    • Tissue-specific divergent outcomes not unified mechanistically

Open questions

Synthesis pass · forward-looking unresolved questions
  • How ROMO1's channel activity, redox-sensing/cysteinome protection, and TIM23 translocase roles are mechanistically integrated into a single molecular function remains unresolved.
  • No structure of ROMO1 within the assembled TIM23 complex
  • Causal hierarchy among channel, ROS-generation, and OPA1/cristae roles not established
  • Substrate-selection rules for the translocase function undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140299 molecular sensor activity 2 GO:0005215 transporter activity 1 GO:0140096 catalytic activity, acting on a protein 1
Localization
GO:0005739 mitochondrion 3
Pathway
R-HSA-5357801 Programmed Cell Death 4 R-HSA-1640170 Cell Cycle 2 R-HSA-1852241 Organelle biogenesis and maintenance 2 R-HSA-8953897 Cellular responses to stimuli 2 R-HSA-392499 Metabolism of proteins 1
Partners
BCL-XLMYCOPA1TIM17TRAF2YME1L
Complex memberships
TIM23 presequence translocase

Evidence

Reading pass · 26 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 ROMO1 (Reactive oxygen species modulator 1) is a novel protein localized in the mitochondria that increases cellular ROS levels when overexpressed. Subcellular fractionation/localization; overexpression with ROS measurement Biochemical and biophysical research communications Medium 16842742
2010 In response to TNF-alpha, TNF complex II (comprising RIP1, TRADD, TRAF2, FADD, and pro-caspase-8) binds to the C-terminus of mitochondrial ROMO1. ROMO1 then recruits BCL-XL to reduce mitochondrial membrane potential, resulting in ROS production and apoptotic cell death, establishing ROMO1 as a molecular bridge between TNF-alpha signaling and mitochondrial ROS production. Co-immunoprecipitation, binding domain mapping, siRNA knockdown with apoptosis and ROS readouts Cell death and differentiation Medium 20203691
2010 ROMO1 knockdown by siRNA blocks mitochondrial ROS production caused by serum deprivation (originating in the mitochondrial electron transport chain) and inhibits serum deprivation-induced apoptosis. siRNA knockdown, mitochondrial ROS measurement, apoptosis assay Apoptosis Medium 19904609
2008 ROMO1-derived ROS are required for normal cell proliferation; ROMO1 knockdown reduces ROS and inhibits cell growth via the ERK pathway, which can be rescued by exogenous hydrogen peroxide. siRNA knockdown, ERK pathway inhibition, exogenous H2O2 rescue experiment Biochemical and biophysical research communications Medium 18313394
2008 Enforced ROMO1 expression triggers premature senescence and DNA damage via ROS production originating in the mitochondrial electron transport chain; endogenous ROMO1 expression increases with replicative age in IMR-90 fibroblasts and ROMO1 knockdown inhibits replicative senescence progression. Overexpression, siRNA knockdown, ROS measurement, senescence assays (SA-β-gal), DNA damage markers The Journal of biological chemistry Medium 18836179
2009 Endogenous ROMO1-derived mitochondrial ROS are required for G1-to-S cell cycle transition in normal WI-38 fibroblasts; ROMO1 knockdown reduces ROS and causes G1 arrest associated with increased p27(Kip1) levels. siRNA knockdown, flow cytometry cell cycle analysis, p27(Kip1) western blot, ROS measurement Free radical research Medium 19513905
2011 Upregulated MYC induces ROMO1 expression; in a negative-feedback loop, ROMO1-derived ROS stimulate SKP2-mediated ubiquitylation and proteasomal degradation of MYC in normal lung fibroblasts. Additionally, pre-existing ROMO1-derived ROS are required for MYC induction and quiescent cell cycle re-entry. Overexpression, siRNA knockdown, ubiquitylation assay, western blot for Myc/Skp2, cell cycle analysis Journal of cell science Medium 21558421
2011 BCL-XL expression blocks serum deprivation-induced and ROMO1-triggered ROS generation and apoptotic cell death, indicating BCL-XL acts downstream of or in parallel to ROMO1 to suppress oxidative stress. BCL-XL overexpression, ROS measurement, apoptosis assay, epistasis with ROMO1 Oncology reports Low 21399876
2013 ROMO1 mediates mitochondrial ROS production through complex III of the mitochondrial electron transport chain and is required for apoptosis induced by oxidative stress (H2O2) in lung epithelial cells; ROMO1 knockdown suppresses cellular ROS and H2O2-induced cell death. siRNA knockdown, complex III identification, ROS measurement, cell death assay Biochemical and biophysical research communications Medium 23867822
2014 ROMO1 is required for mitochondrial fusion and normal cristae morphology; oxidative stress promotes formation of high-molecular-weight ROMO1 complexes; ROMO1 is essential for oligomerization of the inner membrane GTPase OPA1, which maintains cristae junction integrity. ROMO1 knockdown causes mitochondrial fragmentation, loss of cristae, impaired mitochondrial respiration, and increased sensitivity to cell death stimuli. Genome-wide RNAi screen, ROMO1 KD, native PAGE for OPA1 oligomers, electron microscopy of cristae, mitochondrial respiration assay, redox stress treatment Science signaling High 24473195
2014 ROMO1 expression is required to maintain constitutive NF-κB nuclear DNA-binding activity and transcriptional activity via constitutive IκBα phosphorylation in hepatocellular carcinoma cells; ROMO1 overexpression promotes p65 nuclear translocation. siRNA knockdown, overexpression, NF-κB reporter assay, IκBα phosphorylation western blot, p65 nuclear translocation assay Biochemical and biophysical research communications Medium 25044121
2015 ROMO1-induced increase in invasive activity is blocked by an IKK inhibitor, demonstrating that ROMO1-driven tumor cell invasion is mediated through the NF-κB signaling pathway. siRNA knockdown, IKK inhibitor treatment, invasion assay International journal of oncology Medium 25673177
2018 ROMO1 is a constituent of the human TIM23 presequence translocase complex with an exceptionally short half-life. ROMO1 is not required for general presequence import but is specifically required for import of the inner membrane protease YME1L; in ROMO1 knockout cells, YME1L is lost from the inner membrane, leading to aberrant OPA1 processing and altered inner membrane structure. ROMO1 also participates in the dynamics of TIM21 during respiratory chain biogenesis. Mass spectrometry identification of TIM23 complex constituents, ROMO1 KO cell line analysis, import assays, OPA1 processing western blot, TIM21 dynamics analysis The Journal of cell biology High 30598479
2018 ROMO1 forms a nonselective cation channel with its amphipathic helical transmembrane domain necessary for pore-forming activity; structurally resembles class II viroporins; channel activity is specifically inhibited by Fe2+ ions. A hexameric structural model was constructed by experimental data-guided structural bioinformatics. Electrophysiology (channel recording), transmembrane domain mutagenesis, structural bioinformatics/modeling, Fe2+ inhibition assay The Journal of cell biology High 29545371
2019 SRA receptor stimulation activates ERK phosphorylation, which upregulates and activates ROMO1 to enhance mitochondrial ROS production and promote NETs formation in neutrophils; inhibition of ROMO1 dampens SRA-stimulated NET release. Pharmacological inhibition, siRNA knockdown, ERK inhibition, ROS measurement, NET assay Biochemical and biophysical research communications Medium 30850160
2020 ROMO1 overexpression in bone marrow cells results in M2 polarization of bone marrow-derived macrophages through the mTORC1 signaling pathway. Overexpression in bone marrow cells, glioblastoma mouse model, macrophage polarization assay, mTORC1 pathway analysis Aging Low 31945745
2020 ROMO1 inhibition elevates BAX protein levels by downregulating the ubiquitin-proteasome system and downregulates the interaction between BAX and Parkin, thereby sensitizing colorectal cancer cells to TRAIL-mediated mitochondrial apoptosis. siRNA knockdown, western blot for BAX and ubiquitin-proteasome components, Co-IP for BAX-Parkin interaction, TRAIL apoptosis assay, xenograft model Cancers Medium 32825500
2021 ROMO1 knockdown in porcine preimplantation embryos disrupts OPA1 isoform balance, leading to cytochrome c release, reduced ATP, mitochondrial fragmentation, decreased mitochondrial membrane potential, increased ROS production, and induction of apoptosis; ROMO1 overexpression rescues these defects. siRNA knockdown, overexpression rescue, OPA1 western blot, cytochrome c release assay, ATP measurement, mitochondrial morphology imaging Cell division Medium 34915903
2023 TRAF2 deficiency increases ROMO1 expression, which activates the NAD+/SIRT3/SOD2 pathway to promote ROS production, cause mitochondrial dysfunction, and trigger DNA damage response leading to hepatocellular carcinoma senescence. TRAF2 knockdown/KO, ROMO1 western blot, NAD+/SIRT3/SOD2 pathway analysis, mitochondrial function assays, DNA damage markers Free radical biology & medicine Medium 38043870
2023 PKLR undergoes nuclear translocation under androgen-deprivation conditions and binds to the MYCN/MAX complex to upregulate ROMO1 expression; elevated ROMO1 alters mitochondrial function and promotes neuroendocrine differentiation of prostate cancer cells. Nuclear fractionation, Co-IP for PKLR-MYCN/MAX complex, ROMO1 western blot, mitochondrial function assays, NE differentiation markers Redox biology Medium 36963289
2025 ROMO1 overexpression causes a reductive shift in the mitochondrial cysteinome, protecting mitochondrial proteinaceous thiols from oxidation; this promotes energy metabolism and Ca2+ uniport while inhibiting mitochondrial permeability transition. ROMO1 overexpression reverses cysteinome oxidations in aged mice and slows functional decline. Redox proteomics of mitochondrial cysteinome, ROMO1 overexpression in cells and aged mice, mitochondrial respiration assay, Ca2+ uniport measurement, mPTP assay Nature communications High 40461459
2026 ROMO1 is essential for embryonic development (Romo1-null mice die before embryonic day 8.5); conditional ROMO1 knockout in pancreatic beta cells impairs glucose-stimulated insulin secretion and reduces spare respiratory capacity by specifically decreasing complex II/succinate dehydrogenase activity; human islets lacking ROMO1 also show reduced spare respiratory capacity. Whole-body and conditional (beta cell) Romo1 knockout mice, glucose tolerance test, insulin secretion assay, mitochondrial respiratory analysis (Seahorse), isolated human islets with ROMO1 KO Diabetologia High 41995846
2026 ROMO1 silencing in airway epithelial cells suppresses cigarette smoke extract-induced mitochondrial ROS production, STAT6 phosphorylation, and MUC5AC (mucin) expression, placing ROMO1 upstream of a mitochondrial ROS-STAT6 pathway that drives airway mucus hypersecretion. siRNA knockdown, mitochondrial ROS measurement, STAT6 phosphorylation western blot, MUC5AC expression assay, mitochondrial targeted antioxidant and STAT6 inhibitor epistasis Respiratory research Medium 41673839
2025 Selective depletion of ROMO1 in cholinergic neurons in mice causes adult-onset progressive locomotor deficits resembling ALS, with age-dependent motor neuron loss, axon degeneration, disrupted cholinergic transmission, neuromuscular junction denervation, and muscle atrophy; early mitochondrial cristae deformation precedes onset of ALS-like symptoms. Conditional KO in cholinergic neurons, behavioral locomotor assays, motor neuron counting, axon morphology, neuromuscular junction staining, electron microscopy of cristae bioRxivpreprint Medium
2024 Structural modelling predicts ROMO1 forms a channel within the TIM23 core complex together with TIM17, providing an alternative import channel for PINK1 translocation into the matrix; ROMO1/TIM17 and PARL/TIM17 interactions are mutually exclusive, with PINK1 TMD structural plasticity (α-helix vs α/β-hybrid) determining whether it is translocated through the ROMO1/TIM17 channel or cleaved by PARL. Structural modelling, PINK1 import analysis in intact cells, transmembrane domain structural prediction bioRxivpreprint Low
2026 ROMO1 is the most significantly downregulated mitochondrial protein at 24 hours post-high-dose irradiation in keratinocytes; ROMO1 overexpression increases mtROS and mitochondrial membrane potential but suppresses cell viability after radiation; skin-specific Romo1 knockout mice show accelerated wound healing and enhanced tissue regeneration after radiation injury. Mitochondrial proteomics, ROMO1 overexpression, Romo1 skin-specific KO mice, ROS and membrane potential measurement, wound healing and skin injury scoring Journal of Sichuan University. Medical science edition Medium 42021879

Source papers

Stage 0 corpus · 50 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 TNF-alpha-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X(L). Cell death and differentiation 301 20203691
2006 A novel protein, Romo1, induces ROS production in the mitochondria. Biochemical and biophysical research communications 113 16842742
2014 ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics. Science signaling 104 24473195
2010 Serum deprivation-induced reactive oxygen species production is mediated by Romo1. Apoptosis : an international journal on programmed cell death 102 19904609
2012 Overexpression of Romo1 promotes production of reactive oxygen species and invasiveness of hepatic tumor cells. Gastroenterology 70 22749933
2008 A critical role for Romo1-derived ROS in cell proliferation. Biochemical and biophysical research communications 70 18313394
2008 Replicative senescence induced by Romo1-derived reactive oxygen species. The Journal of biological chemistry 60 18836179
2018 ROMO1 is a constituent of the human presequence translocase required for YME1L protease import. The Journal of cell biology 52 30598479
2013 Romo1 expression contributes to oxidative stress-induced death of lung epithelial cells. Biochemical and biophysical research communications 46 23867822
2009 Mitochondrial reactive oxygen species originating from Romo1 exert an important role in normal cell cycle progression by regulating p27(Kip1) expression. Free radical research 42 19513905
2018 Romo1 is a mitochondrial nonselective cation channel with viroporin-like characteristics. The Journal of cell biology 33 29545371
2023 Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production. Journal of nanobiotechnology 28 37386404
2015 Romo1 and the NF-κB pathway are involved in oxidative stress-induced tumor cell invasion. International journal of oncology 25 25673177
2019 Reactive Oxygen Species Modulator 1 (ROMO1), a New Potential Target for Cancer Diagnosis and Treatment. Chonnam medical journal 23 31598470
2014 Serum reactive oxygen species modulator 1 (Romo1) as a potential diagnostic biomarker for non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands) 23 24951318
2011 Romo1 is a negative-feedback regulator of Myc. Journal of cell science 23 21558421
2019 Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis. Journal of cellular physiology 21 31608995
2014 Romo1 is associated with ROS production and cellular growth in human gliomas. Journal of neuro-oncology 21 25193023
2013 Disturbance of DKK1 level is partly involved in survival of lung cancer cells via regulation of ROMO1 and γ-radiation sensitivity. Biochemical and biophysical research communications 21 24269823
2020 Romo1 is involved in the immune response of glioblastoma by regulating the function of macrophages. Aging 20 31945745
2023 Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer. Redox biology 19 36963289
2015 ROMO1 regulates RedOx states and serves as an inducer of NF-κB-driven EMT factors in Fanconi anemia. Cancer letters 19 25687884
2015 The rs6060566 of the reactive oxygen species modulator 1 (Romo-1) gene affects Romo-1 expression and the development of diabetic retinopathy in Caucasians with type 2 diabetes. Acta ophthalmologica 18 25824963
2019 Increased Serum Romo1 Was Correlated with Lung Function, Inflammation, and Oxidative Stress in Chronic Obstructive Pulmonary Disease. Inflammation 17 31049771
2020 TUG1 long non-coding RNA enlists the USF1 transcription factor to overexpress ROMO1 leading to hepatocellular carcinoma growth and metastasis. MedComm 14 34766130
2011 Bcl-XL prevents serum deprivation-induced oxidative stress mediated by Romo1. Oncology reports 14 21399876
2023 TRAF2 inhibits senescence in hepatocellular carcinoma cells via regulating the ROMO1/ NAD+/SIRT3/SOD2 axis. Free radical biology & medicine 13 38043870
2021 ROMO1 is required for mitochondrial metabolism during preimplantation embryo development in pigs. Cell division 13 34915903
2019 Stimulation of the class-A scavenger receptor induces neutrophil extracellular traps (NETs) by ERK dependent NOX2 and ROMO1 activation. Biochemical and biophysical research communications 12 30850160
2014 Constitutive NF-κB activation and tumor-growth promotion by Romo1-mediated reactive oxygen species production. Biochemical and biophysical research communications 11 25044121
2023 Biomimetic cryogel promotes the repair of osteoporotic bone defects through altering the ROS niche via down-regulating the ROMO1. International journal of biological macromolecules 10 38042316
2018 Serum Romo1 is significantly associated with disease severity in patients with obstructive sleep apnea syndrome. Sleep & breathing = Schlaf & Atmung 10 29302924
2020 Romo1 Inhibition Induces TRAIL-Mediated Apoptosis in Colorectal Cancer. Cancers 9 32825500
2017 Reactive oxygen species modulator 1 (Romo1) as a novel diagnostic marker for lung cancer-related malignant effusion. Medicine 8 28121949
2014 Association of Romo1 gene genetic polymorphisms with risk of gastric cancer in northwestern Chinese population. Pathology oncology research : POR 8 25374412
2025 ROMO1 overexpression protects the mitochondrial cysteinome from oxidations in aging. Nature communications 7 40461459
2022 The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review. Chonnam medical journal 7 36245774
2025 HPV Oncoproteins and Mitochondrial Reprogramming: The Central Role of ROMO1 in Oxidative Stress and Metabolic Shifts. Cells 4 41148844
2020 The C allele of the reactive oxygen species modulator 1 (ROMO1) polymorphism rs6060566 is a biomarker predicting coronary artery stenosis in Slovenian subjects with type 2 diabetes mellitus. BMC medical genomics 4 33302957
2023 The effects of ROMO1 on cervical cancer progression. Pathology, research and practice 3 37285738
2025 ROMO1: A Distinct Mitochondrial Protein with Dual Roles in Dynamics and Function. Antioxidants (Basel, Switzerland) 2 40427422
2021 A Novel Peptide Derived from the Transmembrane Domain of Romo1 Is a Promising Candidate for Sepsis Treatment and Multidrug-Resistant Bacteria. International journal of molecular sciences 2 34361008
2025 ROMO1 as a Diagnostic Biomarker in Cervical Neoplasia: Evidence from Normal, Pre-Invasive, and Invasive Lesions. Diagnostics (Basel, Switzerland) 1 41515519
1990 Electron microscopic study of receptor mediated endocytosis of a monoclonal antibody (RoMo-1) against the surface marker CD 14 of human monocytes. Acta histochemica. Supplementband 1 1706877
2026 ROMO1 is involved in airway mucus hypersecretion in COPD through the mitochondrial ROS-STAT6 pathway. Respiratory research 0 41673839
2026 ROMO1 and mitochondrial complex II/SDH are required for spare respiratory capacity and glucose homeostasis in mice. Diabetologia 0 41995846
2026 [ROMO1 Promotes the Repair of Radiation-induced Skin Injury by Regulating Mitochondrial Function and Keratinocyte Proliferation]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 0 42021879
2026 Hypermethylation of ZNF154 promotes malignant potential of ovarian cancer cells by diminishing ZNF154/KAP1-mediated ROMO1 repression. Cell death & disease 0 42069755
2025 A machine learning-driven transcriptomic study reveals the key role of Romo1 in reversing central sensitization through stellate ganglion block in migraine: An interventional study based on a recurrent migraine rat model. Headache 0 40747904
2021 High Expression of ROMO1 Aggravates the Malignancy of Hepatoblastoma. Journal of oncology 0 34512752

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