Affinage

RNF13

E3 ubiquitin-protein ligase RNF13 · UniProt O43567

Length
381 aa
Mass
42.8 kDa
Annotated
2026-06-10
33 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RNF13 is an endolysosomal membrane-anchored RING-type E3 ubiquitin ligase whose catalytic activity and correct subcellular targeting jointly govern its roles in ER stress signaling, lysosomal biology, and synaptic function (PMID:18794910, PMID:24387786). Through its RING domain it functions as a bona fide E3 ligase, with intact catalytic activity required for its cellular effects (PMID:18794910, PMID:24387786). RNF13 acts as a key effector of ER stress-induced apoptosis: it co-immunoprecipitates with and stabilizes IRE1α, activating the IRE1α–TRAF2–(ASK1)–JNK axis and XBP1 splicing, with both the RING and transmembrane domains required (PMID:23378536, PMID:24303962). At endolysosomes, RNF13 directs membrane and trafficking outcomes through substrate ubiquitination: it mediates K48-linked ubiquitination of LAMP-1 at K128 to drive its proteasomal degradation, suppressing lysosome maturation and sustaining endosomal TLR-mediated inflammation (PMID:39031743), and it controls lysosomal positioning by a pH- and Ca2+-dependent mechanism in which His332 deprotonation enables binding to Ca2+-bound ALG-2 and ubiquitin-dependent degradation of ARL8B, opposing anterograde lysosomal transport (PMID:40714633, PMID:42206902). RNF13 is targeted to endolysosomes via a dileucine/AP-3 sorting motif, with a secondary glutamine/AP-1 motif providing an alternative Golgi-to-endosome route (PMID:34831286, PMID:39206621), and its PA domain is independently required for endosomal localization (PMID:24387786). It additionally ubiquitinates snapin via K29-linked chains to promote SNARE complex assembly and synaptic function (PMID:22890573) and interacts with p62 to stabilize NRF2/HO-1 antioxidant signaling (PMID:37852547, PMID:39511649). Heterozygous gain-of-function RNF13 variants (L311S, L312P) cause a human neurodevelopmental disorder, enhancing IRE1α-mediated stress apoptosis while disrupting AP-3 binding and endolysosomal localization (PMID:30595371, PMID:34831286).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2009 High

    Established RNF13 as a catalytically active RING E3 ligase whose activity drives cellular phenotypes, answering whether the protein has intrinsic ubiquitin ligase function.

    Evidence In vitro ubiquitin ligase assay with RING-domain mutagenesis and cell invasion/zymography readouts in pancreatic cancer cells; parallel growth-suppression assays in muscle cells

    PMID:18794910 PMID:20015074

    Open questions at the time
    • No physiological substrate identified at this stage
    • Mechanism linking ligase activity to MMP-9 activity and invasion unresolved
  2. 2010 Medium

    Defined RNF13 as an endosomal membrane protein subject to regulated proteolysis and PKC-dependent redistribution, framing its activity as spatially controlled.

    Evidence Subcellular fractionation, fluorescence microscopy, pharmacological PKC activation and proteasome inhibition

    PMID:21078126

    Open questions at the time
    • Functional consequence of nuclear RING exposure not established
    • Identity of proteases generating cytoplasmic fragment unknown
  3. 2012 High

    Identified snapin as the first defined RNF13 substrate and linked K29-linked ubiquitination to SNARE assembly and learning, establishing a synaptic role.

    Evidence Co-IP, in vitro ubiquitination with K29-linkage determination, RNF13 knockout mice with behavioral and synaptic ultrastructure analysis

    PMID:22890573

    Open questions at the time
    • How non-degradative K29 ubiquitination promotes snapin–SNAP-25 association mechanistically unclear
    • Relationship to endolysosomal localization not addressed
  4. 2013 High

    Placed RNF13 upstream of the IRE1α–TRAF2–JNK axis in ER stress apoptosis by showing it binds and stabilizes IRE1α, defining a signaling rather than purely degradative role.

    Evidence Reciprocal Co-IP, retroviral insertion knockdown epistasis panel, domain mutagenesis, cycloheximide chase, XBP1 splicing and caspase assays across cell lines

    PMID:23378536 PMID:24303962

    Open questions at the time
    • Whether IRE1α stabilization requires RNF13 catalytic ubiquitination not resolved
    • Direct ubiquitination of IRE1α not demonstrated
  5. 2014 Medium

    Showed that endosomal targeting and catalytic activity are separable but both required, with the PA domain controlling localization and tumour mutations dissociating these properties.

    Evidence PA- and RING-domain mutagenesis, in vitro ligase assays, localization microscopy

    PMID:24387786

    Open questions at the time
    • PA domain binding partner mediating localization unknown
    • Substrates ubiquitinated specifically at the endosome not yet defined
  6. 2015 Medium

    Extended RNF13 function to organismal immune-niche regulation, showing knockout alters cytokine milieu (IL-4/IL-6, GM-CSF) affecting muscle regeneration and metastatic colonization.

    Evidence RNF13 knockout mice with cardiotoxin injury and experimental metastasis models, cytokine multiplex/ELISA, antibody-blocking epistasis

    PMID:24563216 PMID:26197965

    Open questions at the time
    • Molecular substrate linking RNF13 to cytokine production unidentified
    • Cell-type-specific mechanism in macrophages not resolved
  7. 2018 Medium

    Linked RNF13 to human disease, showing heterozygous L311S/L312P variants act as gain-of-function alleles enhancing IRE1α stress signaling and apoptosis.

    Evidence Patient-derived cell lines, apoptosis and IRE1α signaling assays, computational structural modeling

    PMID:30595371

    Open questions at the time
    • Structural prediction is computational only
    • How surface variants enhance signaling mechanistically unresolved
  8. 2021 Medium

    Reframed the disease variants as trafficking defects, showing the L311/L312 dileucine motif mediates AP-3 binding required for endolysosomal localization and selective cargo trafficking.

    Evidence GST-pulldown, Co-IP, AP3D1 knockdown, EGF/transferrin trafficking and vesicle-size microscopy

    PMID:34831286

    Open questions at the time
    • Reconciliation between gain-of-function signaling and loss-of-localization not fully resolved
    • Cargo selectivity (EGF vs transferrin) mechanism unclear
  9. 2024 High

    Identified LAMP-1 as a site-specific K48-linked substrate, mechanistically connecting RNF13 to suppression of lysosome maturation and sustained TLR inflammation.

    Evidence E3 ligase screen, site- and linkage-specific ubiquitination assays (K128, K48), proteasome inhibition, lysosomal acidification and TLR readouts, patient PBMCs

    PMID:39031743

    Open questions at the time
    • How proteasomal degradation of a lysosomal membrane protein occurs mechanistically not fully detailed
    • Link to RNF13 disease variants not established
  10. 2024 Medium

    Resolved RNF13 trafficking logic by identifying a secondary glutamine/AP-1 motif providing an alternative Golgi-to-endosome route independent of the dileucine/AP-3 motif.

    Evidence Biochemical interaction assays, Co-IP, sorting-motif mutagenesis and microscopy in HeLa cells

    PMID:39206621

    Open questions at the time
    • Conditions selecting AP-1 vs AP-3 routing in vivo unknown
    • Functional consequence of alternate routing for substrate ubiquitination not defined
  11. 2024 Medium

    Defined a cytoprotective antioxidant arm in which RNF13 binds p62 and stabilizes the p62–NRF2–HO-1 axis, including by blocking TRIM21-mediated p62 degradation.

    Evidence Co-IP, GST-pulldown, mass spectrometry, RNA-seq, KO/AAV9-overexpression mice in cardiac hypertrophy and cerebral I/R models with p62-knockdown epistasis

    PMID:37852547 PMID:39511649

    Open questions at the time
    • Whether p62 stabilization requires RNF13 catalytic activity unclear
    • Direct molecular interplay with TRIM21 not fully mapped
  12. 2025 High

    Established RNF13 as a pH/Ca2+-gated regulator of lysosomal positioning, coupling His332 deprotonation and ALG-2 binding to ubiquitin-dependent ARL8B/Arl8B control of lysosomal transport.

    Evidence His332 and interface-residue mutagenesis, Co-IP of RNF13–ALG-2 and RNF13–Arl8B, ARL8B ubiquitination assays, TRPML3 pharmacology, AlphaFold modeling, lysosomal positioning and EGFR trafficking microscopy

    PMID:40714633 PMID:42206902

    Open questions at the time
    • Integration of ALG-2 activation with Arl8B GDP-preference binding not fully unified
    • In vivo relevance of pH-gated positioning unestablished
  13. 2025 Medium

    Showed RNF13 functions within a heterodimer with RNF167 and modulates IDS maturation, indicating combinatorial E3 activity shapes lysosomal enzyme processing.

    Evidence Co-IP, AlphaFold3 prediction, glycosylation/western analysis, E3 catalytic mutants, proteasome inhibition, Asn246 mutagenesis

    PMID:41387381

    Open questions at the time
    • Mechanism by which the heterodimer alters IDS processing not resolved
    • Substrate specificity changes upon dimerization not mapped
  14. 2025 Medium

    Clarified the disease variants' neuronal mechanism, showing L311S/L312P reroute via AP-1, mislocalize in dendrites, and act as dominant negatives for AP-3-dependent ligase function affecting synaptic markers.

    Evidence Primary rat hippocampal neuron imaging with endosomal/synaptic markers and dominant-negative constructs

    PMID:40276023

    Open questions at the time
    • Reconciliation of dominant-negative trafficking with gain-of-function ER stress signaling unresolved
    • Substrate(s) underlying synaptic marker changes unidentified

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RNF13's distinct activities — IRE1α signaling, snapin/SNARE, LAMP-1/lysosome maturation, ALG-2/ARL8B positioning, p62/NRF2, and IDS/RNF167 — are coordinated within a single endolysosomal ligase, and how disease variants simultaneously gain ER-stress signaling while losing trafficking-dependent functions, remains unresolved.
  • No unified model linking signaling and trafficking arms
  • Spatial/temporal control of substrate choice unknown
  • Comprehensive substrate map incomplete

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 5 GO:0140096 catalytic activity, acting on a protein 4 GO:0016874 ligase activity 3 GO:0140299 molecular sensor activity 1
Localization
GO:0005764 lysosome 3 GO:0005768 endosome 3 GO:0005783 endoplasmic reticulum 2 GO:0005794 Golgi apparatus 2
Pathway
R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-8953897 Cellular responses to stimuli 4 R-HSA-5357801 Programmed Cell Death 3 R-HSA-392499 Metabolism of proteins 2 R-HSA-168256 Immune System 1
Partners
ALG2ARL8BIDSIRE1ALAMP1RNF167SNAPINSQSTM1
Complex memberships
RNF13-RNF167 heterodimer

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2009 RNF13 is an ER/Golgi membrane-associated E3 ubiquitin ligase; its RING finger domain is required for ubiquitin ligase activity, and overexpression of wild-type but not RING domain-mutant RNF13 increases invasive potential and MMP-9 gelatinolytic activity in pancreatic cancer cells. In vitro ubiquitin ligase assay, RING domain mutagenesis, cell invasion/gelatin zymography assays Cell Research High 18794910
2009 RNF13 E3 ligase activity (intact RING finger) is required for its growth-suppressive function in muscle cells; RING domain mutations abolish inhibition of myoblast proliferation and suppression of MyoD/Caveolin-3 expression. Myostatin upregulates RNF13 expression at transcriptional and translational levels. RING domain mutagenesis, ectopic expression, proliferation assays, RT-PCR/western blot The FEBS Journal Medium 20015074
2010 RNF13 localizes to endosomal membranes where it undergoes extensive proteasome-dependent proteolysis; the cytoplasmic RING-domain-containing fragment can be released from the membrane. Upon PKC activation, the full-length protein is stabilized and redistributes to recycling endosomes and the inner nuclear membrane, exposing the RING domain to the nucleoplasm. Subcellular fractionation, fluorescence microscopy, pharmacological PKC activation, proteasome inhibition The FEBS Journal Medium 21078126
2013 RNF13 mediates ER stress-induced apoptosis upstream of the IRE1α–TRAF2–JNK signaling axis. RNF13 co-immunoprecipitates with IRE1α, and both the RING domain and transmembrane domain are required for JNK activation and apoptosis. Knockdown confers resistance to ER stress-induced apoptosis and JNK activation. Co-immunoprecipitation, genetic knockdown (retroviral insertion mutation screen), overexpression, caspase assays, knockdown epistasis panel Journal of Biological Chemistry High 23378536
2013 RNF13 interaction with IRE1α increases IRE1α protein stability (cycloheximide chase), promotes XBP1 mRNA splicing, and activates JNK in neuroblastoma SH-SY5Y cells, confirming a conserved role in ER stress-mediated apoptosis. Co-immunoprecipitation, cycloheximide chase, overexpression, RT-PCR, western blot Journal of Receptor and Signal Transduction Research Medium 24303962
2014 The PA (protease-associated) domain of RNF13 is required for its endosomal localization. PA domain point mutations identified in human tumours retain E3 ligase activity but cause mislocalization of the protein, indicating that both catalytic activity and endosomal targeting are required for substrate ubiquitylation. RING domain tumour mutations abrogate ubiquitin ligase activity. PA domain mutagenesis, RING domain mutagenesis, ubiquitin ligase assays, fluorescence microscopy for localization Biochemical Journal Medium 24387786
2012 RNF13 directly interacts with snapin (a SNAP-25-interacting protein) and ubiquitinates snapin via K29-linked polyubiquitin chains, promoting snapin–SNAP-25 association and SNARE complex assembly. RNF13-null mice show impaired SNARE complex assembly and reduced snapin–SNAP-25 interaction, correlating with spatial learning deficits. Co-immunoprecipitation, in vitro ubiquitination assay with linkage determination, RNF13 knockout mouse, Morris water maze/Y-maze, electron microscopy of synapses Cellular and Molecular Life Sciences High 22890573
2014 RNF13 expressed in macrophages suppresses skeletal muscle regeneration; RNF13-knockout mice show accelerated satellite cell proliferation and elevated IL-4/IL-6 in injured muscle. Blocking IL-4/IL-6 with antibodies abrogates the accelerated regeneration phenotype, placing RNF13 upstream of cytokine-mediated satellite cell niche regulation. RNF13 knockout mouse, cardiotoxin injury model, cytokine multiplex, antibody blocking, immunofluorescence Protein & Cell Medium 24563216
2015 Host RNF13 reduces pulmonary colonization of metastatic tumor cells by maintaining GM-CSF levels in the lung; RNF13-knockout mice show reduced GM-CSF in tumor-bearing lungs and conditioned media from lung slices, correlating with enhanced metastatic foci. RNF13 knockout mouse, B16F10/LLC experimental metastasis model, cytokine ELISA, conditioned media experiments Protein & Cell Medium 26197965
2018 Heterozygous gain-of-function variants in RNF13 (L311S, L312P) cause enhanced IRE1α-mediated stress signaling and increased stress-induced apoptosis in patient-derived cells, without altering RNF13 or IRE1α protein abundance. Structural modeling predicts surface location of variants without disrupting overall fold. Patient-derived cell lines, apoptosis assays, IRE1α signaling assays, structural modeling American Journal of Human Genetics Medium 30595371
2020 RNF13 knockdown alleviates dopaminergic neuron damage and motor deficits in MPTP-induced Parkinson's disease mouse models and MPP+-treated SH-SY5Y cells by inhibiting the IRE1α–TRAF2–ASK1–JNK ER stress pathway, reducing apoptosis and Ca2+ elevation. shRNA knockdown in vivo and in vitro, western blot for pathway components, TUNEL/TH immunofluorescence, behavioral tests, Ca2+ measurement Journal of Molecular Neuroscience Medium 32617872
2021 Disease-associated RNF13 variants L311S and L312P (dileucine motif) disrupt interaction with the AP-3 adaptor complex and endosomal/lysosomal localization, alter endosomal vesicle size, and affect EGF (but not transferrin) trafficking. Knockdown of AP-3 subunit AP3D1 similarly mislocalizes wild-type RNF13. GST-pulldown, co-immunoprecipitation, fluorescence microscopy, EGF/transferrin trafficking assays, AP3D1 knockdown Cells Medium 34831286
2024 RNF13 mediates K48-linked polyubiquitination of LAMP-1 at residue K128, targeting LAMP-1 for proteasomal degradation. This suppresses lysosome maturation and thereby delays TLR lysosomal degradation, promoting endosomal TLR-mediated inflammatory signaling in macrophages. E3 ligase screen (103 ligases), ubiquitination assays with linkage and site identification (K128), proteasome inhibition, lysosomal acidification assays, TLR signaling readouts, patient PBMCs Advanced Science High 39031743
2024 A glutamine-based secondary motif in the C-terminal region of RNF13 binds AP-1 adaptor complex (distinct from the dileucine/AP-3 motif), providing an alternative Golgi-to-endosome trafficking route when the dileucine motif is mutated. Biochemical interaction assays, co-immunoprecipitation, fluorescence microscopy in HeLa cells, mutagenesis of sorting motifs Journal of Cell Science Medium 39206621
2023 RNF13 directly interacts with p62 (co-immunoprecipitation, GST pulldown) and promotes activation of the p62–NRF2–HO-1 signaling axis to protect against cardiac hypertrophy; p62 knockdown reverses the cardioprotective effect of RNF13 overexpression. Co-immunoprecipitation, GST-pulldown, RNF13 knockout and AAV9-overexpression mouse models, TAC cardiac hypertrophy model, RNA-seq, p62 knockdown epistasis Free Radical Biology & Medicine Medium 37852547
2024 RNF13 protects neurons against ischemia-reperfusion injury by interacting with p62 (co-immunoprecipitation, GST-pulldown) and blocking TRIM21-mediated autophagy-dependent degradation of p62, thereby stabilizing p62–NRF2–HO-1 signaling and reducing apoptosis and inflammation. CRISPR/Cas9 knockout mice, co-immunoprecipitation, GST-pulldown, mass spectrometry, RNA-seq, immunofluorescence, I/R injury model Cell Communication and Signaling Medium 39511649
2025 RNF13 regulates lysosomal positioning through pH- and Ca2+-dependent mechanisms: elevated intracellular pH deprotonates RNF13 at His332, enabling interaction with Ca2+-bound ALG-2, which activates RNF13 to ubiquitinate and degrade ARL8B, thereby inhibiting ARL8B-mediated anterograde lysosomal transport. Alkaline extracellular pH activates TRPML3 to increase lysosomal Ca2+, further enhancing RNF13 activity and driving perinuclear lysosomal positioning. His332 mutagenesis, co-immunoprecipitation of RNF13-ALG-2, ubiquitination assays for ARL8B, lysosomal positioning microscopy, TRPML3 channel pharmacology, pH manipulation Cell Reports High 40714633
2025 RNF13 binds the small GTPase Arl8B (via Arl8B residues Glu22 and Phe55 and RNF13 residue Leu244), with modest preference for GDP-bound Arl8B. Disrupting this interaction redistributes lysosomes to the cell periphery and delays EGFR trafficking toward lysosomal degradation without affecting general endocytosis. AlphaFold structural modeling, co-immunoprecipitation, mutagenesis of interface residues, lysosomal positioning microscopy, EGFR trafficking assays The FEBS Journal Medium 42206902
2025 RNF13 interacts with iduronate 2-sulfatase (IDS), preferentially binding an underglycosylated immature form, and its E3 ligase catalytic activity is required to generate this underglycosylated IDS form (which is otherwise rapidly degraded by the proteasome); RNF13 exerts a net protective effect on IDS. RNF13 forms a heterodimer with RNF167, altering both proteins' lysosomal trafficking and modifying IDS processing differently than either E3 ligase alone. Co-immunoprecipitation, AlphaFold3 prediction, western blot glycosylation analysis, E3 ligase mutants, proteasome inhibition, site-directed mutagenesis (Asn246) The FEBS Journal Medium 41387381
2025 RNF13 variants L311S and L312P are trafficked through an AP-1-dependent pathway in neurons and accumulate at higher levels in dendrites than wild-type RNF13. These variants alter early endosome (EEA1+) distribution in dendrites, reduce distal lysosome (Lamp1+) presence, fail to increase PSD-95 in distal dendrites, and decrease total Gephyrin puncta, acting primarily as dominant negatives for AP-3-dependent ubiquitin ligase function. Primary rat hippocampal neuron culture, fluorescence microscopy, dominant-negative constructs, AP-3 defective binding variants IBRO Neuroscience Reports Medium 40276023

Source papers

Stage 0 corpus · 33 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer. Cell research 61 18794910
2013 RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1α)/c-Jun NH2-terminal kinase pathway. The Journal of biological chemistry 50 23378536
1996 Identification and characterization of a RING zinc finger gene (C-RZF) expressed in chicken embryo cells. Proceedings of the National Academy of Sciences of the United States of America 34 8610176
2010 RNF13: an emerging RING finger ubiquitin ligase important in cell proliferation. The FEBS journal 33 21078127
2014 Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization. The Biochemical journal 30 24387786
2011 Hydrogen production by the newly isolated Clostridium beijerinckii RZF-1108. Bioresource technology 29 21421301
2021 Circ-RNF13, as an oncogene, regulates malignant progression of HBV-associated hepatocellular carcinoma cells and HBV infection through ceRNA pathway of circ-RNF13/miR-424-5p/TGIF2. Bosnian journal of basic medical sciences 26 33714261
2018 Heterozygous RNF13 Gain-of-Function Variants Are Associated with Congenital Microcephaly, Epileptic Encephalopathy, Blindness, and Failure to Thrive. American journal of human genetics 23 30595371
2012 E3 ubiquitin ligase RNF13 involves spatial learning and assembly of the SNARE complex. Cellular and molecular life sciences : CMLS 23 22890573
2014 Accelerated regeneration of the skeletal muscle in RNF13-knockout mice is mediated by macrophage-secreted IL-4/IL-6. Protein & cell 22 24563216
2009 The myostatin-induced E3 ubiquitin ligase RNF13 negatively regulates the proliferation of chicken myoblasts. The FEBS journal 21 20015074
2020 The Regulation of circRNA RNF13/miRNA-1224-5p Axis Promotes the Malignant Evolution in Acute Myeloid Leukemia. BioMed research international 20 33083473
2020 Silencing RNF13 Alleviates Parkinson's Disease - Like Problems in Mouse Models by Regulating the Endoplasmic Reticulum Stress-Mediated IRE1α-TRAF2-ASK1-JNK Pathway. Journal of molecular neuroscience : MN 16 32617872
2024 E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP-1 Proteasomal Degradation. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 14 39031743
2004 RZF, a zinc-finger protein in the photoreceptors of human retina. Gene 13 15527981
2010 Trafficking and proteolytic processing of RNF13, a model PA-TM-RING family endosomal membrane ubiquitin ligase. The FEBS journal 12 21078126
2024 RNF13 protects neurons against ischemia-reperfusion injury via stabilizing p62-mediated Nrf2/HO-1 signaling pathway. Cell communication and signaling : CCS 10 39511649
2015 Enhanced metastasis in RNF13 knockout mice is mediated by a reduction in GM-CSF levels. Protein & cell 10 26197965
2022 Circ_RNF13 Regulates the Stemness and Chemosensitivity of Colorectal Cancer by Transcriptional Regulation of DDX27 Mediated by TRIM24 Stabilization. Cancers 8 36551703
2021 MiR-32-3p Regulates Myocardial Injury Induced by Microembolism and Microvascular Obstruction by Targeting RNF13 to Regulate the Stability of Atherosclerotic Plaques. Journal of cardiovascular translational research 8 34185281
2021 RNF13 Dileucine Motif Variants L311S and L312P Interfere with Endosomal Localization and AP-3 Complex Association. Cells 8 34831286
2013 RNF13 protein regulates endoplasmic reticulum stress induced apoptosis in dopaminergic SH-SY5Y cells by enhancing IRE1α stability. Journal of receptor and signal transduction research 6 24303962
2024 AP-1 contributes to endosomal targeting of the ubiquitin ligase RNF13 via a secondary and novel non-canonical binding motif. Journal of cell science 5 39206621
2023 RNF13 protects against pathological cardiac hypertrophy through p62-NRF2 pathway. Free radical biology & medicine 5 37852547
2023 Heterozygous gain of function variants in a critical region of RNF13 cause congenital microcephaly, epileptic encephalopathy, blindness, and failure to thrive. American journal of medical genetics. Part A 4 37668308
2025 YAP1::MAML2, YAP1::NUTM1, and RNF13::PAK2 rearrangements in trichoblastomas and adnexal tumors with panfollicular differentiation: expanding the spectrum of YAP1/PAK-fused skin adnexal tumors. Virchows Archiv : an international journal of pathology 3 40689944
2025 RNF13 mediates pH- and Ca2+-dependent regulation of lysosomal positioning. Cell reports 2 40714633
2016 Inversion induced Manihot esculenta stem tubers express key tuberization genes; Mec1, RZF, SuSy1 and PIN2. Plant signaling & behavior 2 26785907
2025 RNF13 variants L311S and L312P associated with developmental epileptic encephalopathy alter dendritic organization in hippocampal neurons. IBRO neuroscience reports 1 40276023
2022 Identification of RNF13 as cause of recessively inherited ALS in a multi-case pedigree. Journal of medical genetics 1 35879052
2020 Correction to: Silencing RNF13 Alleviates Parkinson's Disease - Like Problems in Mouse Models by Regulating the Endoplasmic Reticulum Stress-Mediated IRE1α-TRAF2-ASK1-JNK Pathway. Journal of molecular neuroscience : MN 1 33146809
2026 RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B. The FEBS journal 0 42206902
2025 RNF13 is a previously undescribed interactor of iduronate 2-sulfatase that modifies its glycosylation and maturation. The FEBS journal 0 41387381

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