Affinage

RIMBP2

RIMS-binding protein 2 · UniProt O15034

Round 2 corrected
Length
1052 aa
Mass
116.0 kDa
Annotated
2026-04-28
72 papers in source corpus 9 papers cited in narrative 9 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RIMBP2 is a presynaptic active zone scaffold that couples Ca²⁺ channel recruitment to synaptic vesicle docking, priming, and fusion. Through its SH3 domains and fibronectin type III repeats, RIMBP2 binds RIM proteins, voltage-gated Ca²⁺ channels (Cav2/P/Q-type and Cav1.3), and Munc13-1, organizing a multi-protein complex that controls release probability in a synapse-type-specific manner: at hippocampal mossy fiber synapses it is critical for vesicle priming and Ca²⁺ channel abundance, whereas at Schaffer collateral synapses its loss produces only mild effects (PMID:31535974, PMID:38329474). Beyond canonical synapses, RIMBP2 scaffolds exocytic machinery in secretory cells by bridging exophilin-8/Rab27-tagged granules to cortical actin via myosin-VIIa (PMID:28673385), modulates Cav1.3 channel gating properties at cochlear ribbon synapses (PMID:31848688), and is essential for outer hair cell survival and inner hair cell exocytosis underlying normal hearing (PMID:40880039). RIMBP2 is a direct transcriptional target of TCF4, and its reduced expression mediates presynaptic transmission deficits in Pitt-Hopkins syndrome patient-derived cortical neurons (PMID:37573005).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2000 Medium

    Identifying RIM-BPs as RIM-interacting adaptor proteins established the first molecular link between the vesicle release machinery and Ca²⁺ channels at the active zone.

    Evidence Yeast two-hybrid screen and GST pull-down showing RIM-BP2 SH3 domain binds the proline-rich region of RIM1

    PMID:10748113

    Open questions at the time
    • No functional consequence of the interaction was tested
    • Binding to Ca²⁺ channels was inferred from domain architecture but not demonstrated
    • Single study without independent confirmation
  2. 2007 Medium

    Characterization of the RIM-BP gene family across vertebrates revealed conserved domain architecture and overlapping brain expression of RIMBP1 and RIMBP2, suggesting partially redundant synaptic scaffolding roles.

    Evidence Comparative genomics, quantitative RT-PCR, and in situ hybridization across species

    PMID:17855024

    Open questions at the time
    • No functional comparison between RIMBP1 and RIMBP2 was performed
    • Protein-level expression and subcellular localization not resolved
    • Single lab study
  3. 2017 High

    Discovery that RIMBP2 bridges granule-bound exophilin-8 to cortical actin via myosin-VIIa extended its scaffolding function beyond neuronal synapses to secretory granule exocytosis in pancreatic β-cells.

    Evidence Co-immunoprecipitation, knockout/knockdown in β-cells, live imaging, and insulin secretion assays in exophilin-8-null mouse islets

    PMID:28673385

    Open questions at the time
    • Whether this granule-anchoring mechanism operates in other endocrine cell types is untested
    • Structural basis of the exophilin-8–RIMBP2 interaction is unknown
  4. 2019 High

    Synapse-type-specific analysis in RIMBP2 knockout mice demonstrated that RIMBP2 is critical for vesicle docking/priming and Munc13-1 stabilization at mossy fiber synapses but largely dispensable at Schaffer collateral synapses, revealing that active zone architecture dictates RIMBP2 dependence.

    Evidence Electrophysiology, electron microscopy vesicle docking quantification, and immunostaining in RIMBP2 KO mice across hippocampal synapse types

    PMID:31535974

    Open questions at the time
    • The structural basis of differential RIMBP2 dependence across synapse types is unclear
    • Contribution of RIMBP1 compensation at Schaffer collateral synapses not directly tested
  5. 2019 High

    Reconstitution of the RIM2α–RBP2–Cav1.3 complex in heterologous cells showed that RIMBP2 modulates Cav1.3 channel gating in a splice-variant-dependent manner, explaining how ribbon synapse Ca²⁺ channels are tuned for sustained signaling in cochlear hair cells.

    Evidence Whole-cell patch-clamp in tsA-201 cells co-expressing Cav1.3 splice variants with RIM2α and RBP2, immunostaining co-localization in inner hair cells

    PMID:31848688

    Open questions at the time
    • Whether RIMBP2 modulates other Cav channel family members in similar fashion is untested
    • In vivo confirmation of gating modulation by selective RIMBP2 removal from IHCs was lacking at this time
  6. 2023 High

    Identification of RIMBP2 as the top differentially expressed gene downstream of TCF4 in Pitt-Hopkins syndrome neurons, with functional rescue by presynaptic RIMBP2 overexpression, established a causal chain from disease-associated transcription factor to presynaptic scaffold to network-level phenotype.

    Evidence RNA-seq of TCF4-mutant iPSC-derived cortical neurons, electrophysiology, Ca²⁺ imaging, multielectrode arrays, and viral RIMBP2 rescue

    PMID:37573005

    Open questions at the time
    • Direct TCF4 binding at the RIMBP2 promoter was not shown (transcriptional regulation inferred from expression data)
    • Whether RIMBP2 downregulation accounts for all presynaptic deficits in PTHS is unclear
  7. 2024 High

    Direct presynaptic recordings and super-resolution imaging at mossy fiber boutons resolved that RIMBP2 has two separable functions—Ca²⁺ channel recruitment to active zones and vesicle fusion competence—since increasing Ca²⁺ influx only partially rescued release in RIMBP2 knockouts.

    Evidence Direct presynaptic whole-cell capacitance recordings, EPSC measurements, STED microscopy in RIMBP2 KO mice

    PMID:38329474

    Open questions at the time
    • Molecular mechanism by which RIMBP2 promotes fusion competence independently of Ca²⁺ channel positioning is not defined
    • Whether these dual functions are mediated by distinct RIMBP2 domains is unknown
  8. 2025 High

    RIMBP2 knockout mice exhibit severe hearing loss due to outer hair cell apoptosis and impaired inner hair cell exocytosis (reduced readily-releasable pool, blocked fast endocytosis), establishing RIMBP2 as essential for auditory function beyond Ca²⁺-secretion coupling.

    Evidence RIMBP2 KO mice, auditory brainstem response, patch-clamp capacitance in IHCs, immunostaining, TUNEL assay

    PMID:40880039

    Open questions at the time
    • Mechanism linking RIMBP2 loss to OHC apoptosis is unknown
    • Whether the endocytosis defect is a direct or indirect consequence of RIMBP2 loss is unresolved
  9. 2025 Medium

    FRET biosensor experiments revealed that RIMBP2 undergoes an actin-dependent conformational rotation during vesicle release, functioning as a mechanical crane that translocates vesicles toward the presynaptic membrane.

    Evidence FRET biosensors in primary cortical neurons and SH-SY5Y cells, actin disruption pharmacology, RIMBP2 mutagenesis

    PMID:40999007

    Open questions at the time
    • Requires independent replication with alternative biophysical approaches
    • Structural basis of the conformational change is not resolved at atomic level
    • Whether this crane mechanism operates at all synapse types is untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the atomic structure of RIMBP2 in complex with its partners, the molecular basis of synapse-type-specific RIMBP2 dependence, and whether RIMBP2 conformational dynamics are directly coupled to vesicle priming versus fusion.
  • No high-resolution structure of RIMBP2 or its complexes exists
  • Redundancy between RIMBP1 and RIMBP2 is not mechanistically dissected
  • Whether the RIMBP2-dependent endocytosis function in IHCs involves direct protein interactions is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0005198 structural molecule activity 3 GO:0098772 molecular function regulator activity 1
Localization
GO:0005886 plasma membrane 4 GO:0005829 cytosol 2 GO:0005856 cytoskeleton 2
Pathway
R-HSA-112316 Neuronal System 5 R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-9709957 Sensory Perception 2
Partners
CACNA1DEXPH5MYO7ARAB27ARIMS1RIMS2UNC13A
Complex memberships
Exophilin-8–RIMBP2–Myosin-VIIa granule anchoring complexRIM-RIMBP-Cav active zone complex

Evidence

Reading pass · 9 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 RIM-binding proteins (RIM-BPs) were identified as binding partners of presynaptic active zone protein RIM1 through yeast two-hybrid and GST pull-down assays. RIM-BP2 (and RIM-BP1) contain three SH3 domains and two to three fibronectin type III repeats; the second SH3 domain of RIM-BP binds to a conserved proline-rich sequence in RIM1 located between its two C2 domains. This established RIM-BPs as molecular adaptors potentially linking the synaptic vesicle fusion apparatus to Ca²⁺ channels at the active zone. Yeast two-hybrid screen, GST pull-down assay The Journal of biological chemistry Medium 10748113
2007 RIM-BP1 and RIM-BP2 share a conserved domain architecture across vertebrates consisting of three SH3 domains and two to three fibronectin type III repeats. The family diversified during evolution: invertebrates encode one RIM-BP, vertebrates at least two (RIM-BP1 and RIM-BP2), plus a mammalian-specific single-exon gene RIM-BP3. RIM-BP1 and RIM-BP2 show overlapping but distinct brain expression patterns by in situ hybridization, consistent with roles as synaptic molecular adaptors. Comparative genomics, quantitative RT-PCR, in situ hybridization Gene Medium 17855024
2017 RIM-BP2 was identified as a novel binding partner of exophilin-8 (Slp homolog lacking C2 domains protein 1/MyRIP) in pancreatic β-cells and other secretory cells. Co-immunoprecipitation and knockdown experiments demonstrated that RIM-BP2 bridges exophilin-8 (which binds Rab27 on granule membranes) to myosin-VIIa, thereby anchoring secretory granules within the cortical F-actin network. RIM-BP2 also associates with Cav1.3, RIM, and Munc13-1, forming a scaffold linking the granule-anchoring complex to the exocytic machinery. Ablation or knockdown of any component (exophilin-8, RIM-BP2, or myosin-VIIa) markedly decreased peripheral accumulation and exocytosis of granules; exophilin-8-null mouse islets showed impaired insulin secretion. Co-immunoprecipitation, yeast two-hybrid, gene knockout/knockdown, live imaging, insulin secretion assay eLife High 28673385
2019 At hippocampal CA3-CA1 (Schaffer collateral) synapses, RIM-BP2 loss has only a mild effect on neurotransmitter release, primarily reducing Ca²⁺-secretion coupling. In contrast, at hippocampal mossy fiber synapses, RIM-BP2 plays a substantially larger role: its loss impairs vesicle docking/priming and reduces vesicular release probability. Mechanistically, RIM-BP2 promotes vesicle priming at mossy fiber active zones via stabilization of Munc13-1. This demonstrates that RIM-BP2 contributes to synaptic diversity by playing synapse-type-specific roles dictated by differences in active zone architecture. Electrophysiology (whole-cell patch-clamp, field recordings), electron microscopy (vesicle docking quantification), immunostaining, RIM-BP2 knockout mice eLife High 31535974
2019 RIM-binding protein 2 (RBP2/RIMBP2) co-localizes with Cav1.3 Ca²⁺ channels and synaptic ribbons in cochlear inner hair cells (IHCs). When co-expressed with the β3 auxiliary subunit in tsA-201 cells, the combination of RIM2α and RBP2 reduces voltage-dependent inactivation (VDI) of the Cav1.3 long isoform (Cav1.3L) to levels matching those observed in native IHCs. This effect is splice-variant-dependent: a short Cav1.3 splice variant (Cav1.342A) lacking the C-terminal RBP2 interaction site is not modulated by RIM2α/RBP2 in the same manner. Co-expression with RIM2α and/or RBP2 also consolidates the negative voltage operating range by shifting activation threshold toward more hyperpolarized potentials. Whole-cell patch-clamp electrophysiology (tsA-201 heterologous expression), immunostaining/co-localization, splice-variant mutagenesis analysis Pflugers Archiv : European journal of physiology High 31848688
2023 TCF4, a transcription factor mutated in Pitt-Hopkins syndrome (PTHS), transcriptionally regulates RIMBP2 expression in human cortical neurons. RNA-seq of patient iPSC-derived cortical neurons identified RIMBP2 as the most differentially expressed gene in PTHS neurons. TCF4-dependent deficits in spontaneous synaptic transmission and network excitability were rescued by overexpression of RIMBP2 specifically in presynaptic neurons, establishing RIMBP2 as a key downstream effector of TCF4 in regulating presynaptic neurotransmission. iPSC-derived cortical neuron differentiation, whole-cell electrophysiology, Ca²⁺ imaging, multielectrode arrays, RNA sequencing, viral RIMBP2 overexpression rescue Biological psychiatry High 37573005
2024 At hippocampal mossy fiber terminals, RIM-BP2 regulates both Ca²⁺ channel abundance at active zones and synaptic vesicle fusion competence. Direct presynaptic capacitance recording and STED super-resolution microscopy of RIM-BP2 knockout mice revealed reduced P/Q-type Ca²⁺ channel abundance at active zones, reduced Ca²⁺ currents, lowered initial release probability, and impaired vesicle fusion competence. Larger Ca²⁺ influx could partially restore release, indicating that Ca²⁺ channel recruitment and vesicle priming are separable functions both requiring RIM-BP2. Direct presynaptic whole-cell patch-clamp recording, EPSC measurements, membrane capacitance measurements, STED super-resolution microscopy, RIM-BP2 knockout mice eLife High 38329474
2025 RIMBP2 knockout mice exhibit severe hearing loss with elevated auditory brainstem response thresholds, prolonged latencies, and reduced Wave I amplitudes. In outer hair cells (OHCs), RIMBP2 loss leads to apoptotic cell death correlated with threshold elevation. In inner hair cells (IHCs), patch-clamp recordings revealed reduced exocytosis including a diminished readily-releasable pool, impaired sustained release, and blocked fast endocytosis, without a change in ribbon synapse number but with positional shifts of synapses at the basal IHC pole. This establishes RIMBP2 as essential for OHC survival and for multiple aspects of IHC synaptic transmission beyond Ca²⁺-secretion coupling. RIMBP2 knockout mouse model, auditory brainstem response recording, patch-clamp capacitance measurements, immunostaining, TUNEL apoptosis assay Neuroscience bulletin High 40880039
2025 Using FRET-based molecular biosensors built on RIM-BP2's structure, RIM-BP2 was shown to undergo a conformational rotation during synaptic vesicle release, acting like a 'crane': the N-terminal end moves away from the presynaptic membrane while the C-terminal end moves closer. Disruption of actin microfilaments or enhanced membrane fluidity inhibited this rotation. Mutagenesis of RIM-BP2 demonstrated that actin filaments exert mechanical stress through the RIM-BP2 N-terminus to power vesicle transport toward the presynaptic membrane for fusion, identifying a mechanical pathway of vesicle translocation. FRET biosensors (BKTS and RKTS), live imaging in primary cortical neurons and SH-SY5Y cells, actin disruption pharmacology, RIM-BP2 mutagenesis Communications biology Medium 40999007

Source papers

Stage 0 corpus · 72 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2009 Defining the human deubiquitinating enzyme interaction landscape. Cell 1282 19615732
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2007 RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell 441 17320161
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2007 The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell 351 17320163
2009 Docking motif-guided mapping of the interactome of protein phosphatase-1. Chemistry & biology 269 19389623
2008 Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes & development 250 18483221
2005 Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. Molecular cell 196 15949438
2000 The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. The Journal of biological chemistry 192 10748113
1997 Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA research : an international journal for rapid publication of reports on genes and genomes 187 9205841
1993 Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Oncogene 156 8414517
2009 The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells. Gastroenterology 135 19850045
2013 Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis. Cancer research 127 23722541
2011 Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proceedings of the National Academy of Sciences of the United States of America 123 21788502
2008 Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation. Molecular cell 112 18722178
2010 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Molecular medicine (Cambridge, Mass.) 108 20379614
2019 The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. Genes & development 99 31727771
2008 The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif. Nature structural & molecular biology 99 18270511
2011 Genome-wide association study of Alzheimer's disease with psychotic symptoms. Molecular psychiatry 96 22005930
2014 Histone demethylase RBP2 is critical for breast cancer progression and metastasis. Cell reports 89 24582965
2007 RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation. Genes to cells : devoted to molecular & cellular mechanisms 81 17573780
2020 Depletion of LncRNA NEAT1 Rescues Mitochondrial Dysfunction Through NEDD4L-Dependent PINK1 Degradation in Animal Models of Alzheimer's Disease. Frontiers in cellular neuroscience 70 32140098
2001 Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription. The Journal of biological chemistry 67 11358960
2008 RBP2-H1/JARID1B is a transcriptional regulator with a tumor suppressive potential in melanoma cells. International journal of cancer 65 17973255
2005 Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. Biochemical and biophysical research communications 56 16112646
2018 Role of RBP2-Induced ER and IGF1R-ErbB Signaling in Tamoxifen Resistance in Breast Cancer. Journal of the National Cancer Institute 55 29028222
2009 Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 51 19762557
2016 MiR-34a Promotes Osteogenic Differentiation of Human Adipose-Derived Stem Cells via the RBP2/NOTCH1/CYCLIN D1 Coregulatory Network. Stem cell reports 49 27453008
2014 Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis. Molecular cancer 45 24716659
2019 RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses. eLife 44 31535974
2007 Structure and evolution of RIM-BP genes: identification of a novel family member. Gene 38 17855024
2010 Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. Human molecular genetics 37 21078624
2020 Retinol-binding protein 2 (RBP2): biology and pathobiology. Critical reviews in biochemistry and molecular biology 32 32466661
2014 Retinoblastoma binding protein 2 (RBP2) promotes HIF-1α-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway. PloS one 32 25162518
2015 Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia. Oncotarget 31 25575817
2015 Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-β1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit. Oncotarget 29 25974964
2023 The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain. Nucleic acids research 28 36537216
1999 Closing in on the BPES gene on 3q23: mapping of a de Novo reciprocal translocation t(3;4)(q23;p15.2) breakpoint within a 45-kb cosmid and mapping of three candidate genes, RBP1, RBP2, and beta'-COP, distal to the breakpoint. Genomics 27 10191085
2020 Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight. Science advances 25 32195347
2013 RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer. PloS one 25 24376841
2023 Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Cell reports 20 36724073
2017 Xue-fu-Zhu-Yu decoction protects rats against retinal ischemia by downregulation of HIF-1α and VEGF via inhibition of RBP2 and PKM2. BMC complementary and alternative medicine 20 28709426
2007 The polyphyletic nature of Pleosporales: an example from Massariosphaeria based on rDNA and RBP2 gene phylogenies. Mycological research 20 17998156
2019 Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Cancer research 19 30862715
2017 Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa. eLife 19 28673385
2014 Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells. Oncotarget 18 25015565
2019 RBP2 stabilizes slow Cav1.3 Ca2+ channel inactivation properties of cochlear inner hair cells. Pflugers Archiv : European journal of physiology 16 31848688
2018 Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase. Proceedings of the National Academy of Sciences of the United States of America 15 29610306
2004 Identification of Plasmodium falciparum reticulocyte binding protein RBP-2 homologue a and b (PfRBP-2-Ha and -Hb) sequences that specifically bind to erythrocytes. Parasitology international 15 14984838
2016 Retinoblastoma-binding protein 2 (RBP2) is frequently expressed in neuroendocrine tumors and promotes the neoplastic phenotype. Oncogenesis 14 27548814
2023 TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons. Biological psychiatry 13 37573005
2019 Histone demethylase RBP2 mediates the blast crisis of chronic myeloid leukemia through an RBP2/PTEN/BCR-ABL cascade. Cellular signalling 13 31374292
2018 Dynamic site-specific recruitment of RBP2 by pocket protein p130 modulates H3K4 methylation on E2F-responsive promoters. Nucleic acids research 11 29059406
2005 Master or slave: the complex relationship of RBP2 and pRb. Cancer cell 11 15950898
2021 miR-181d/RBP2/NF-κB p65 Feedback Regulation Promotes Chronic Myeloid Leukemia Blast Crisis. Frontiers in oncology 10 33842368
2020 The Blood Stage Antigen RBP2-P1 of Plasmodium vivax Binds Reticulocytes and Is a Target of Naturally Acquired Immunity. Infection and immunity 9 32014895
2018 Chromatin remodeling: demethylating H3K4me3 of type I IFNs gene by Rbp2 through interacting with Piasy for transcriptional attenuation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 9 28970247
2013 Immunohistochemical expression of RBP2 and LSD1 in papillary thyroid carcinoma. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 7 24068396
2025 EndoMAP.v1 charts the structural landscape of human early endosome complexes. Nature 6 40437099
2023 Roles for the Synechococcus elongatus RNA-Binding Protein Rbp2 in Regulating the Circadian Clock. Journal of biological rhythms 6 37515350
2022 Retinol-binding protein 2 (RBP2): More than just dietary retinoid uptake. Biochimica et biophysica acta. Molecular and cell biology of lipids 6 35533980
2015 siRNA targeting RBP2 inhibits expression, proliferation, tumorigenicity and invasion in thyroid carcinoma cells. Oncology letters 4 26788140
2016 RBP2 Promotes Adult Acute Lymphoblastic Leukemia by Upregulating BCL2. PloS one 3 27008505
2025 Multifaceted Role of RIMBP2 in Promoting Hearing in Murine Cochlear Hair Cells. Neuroscience bulletin 1 40880039
2024 RIM-BP2 regulates Ca2+ channel abundance and neurotransmitter release at hippocampal mossy fiber terminals. eLife 1 38329474
2023 TCF4 mutations disrupt synaptic function through dysregulation of RIMBP2 in patient-derived cortical neurons. bioRxiv : the preprint server for biology 1 36712024
2025 Visualization of RIM-BP2's crane-like function in neuronal vesicle transport using FRET. Communications biology 0 40999007
2025 RBP2 promotes gastric cancer cell migration by acting as a competitive endogenous RNA to upregulate SOX4 via sponging miR-212-3p. Scientific reports 0 41372307
2025 Circadian clock proteins KaiB and Rbp2 of Synechococcus elongatus display oscillations in their subcellular localization patterns. Microbiology spectrum 0 41451986
2022 [Effect of RBP2 gene silencing on proliferation, migration and invasion of ovarian epithelial cancer SKOV3/DDP cells and its mechanism]. Zhonghua zhong liu za zhi [Chinese journal of oncology] 0 35184457