Affinage

RBM25

RNA-binding protein 25 · UniProt P49756

Length
843 aa
Mass
100.2 kDa
Annotated
2026-06-10
29 papers in source corpus 20 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RBM25 is an RNA-binding splicing factor that directly recognizes specific pre-mRNA elements—including CGGGCA sequences, poly-G-rich motifs, and RNA G-quadruplexes—to control alternative splice site selection across the transcriptome (PMID:18663000, PMID:37811881, PMID:39110401). At the BCL-x locus it binds an exonic CGGGCA element and an adjacent RNA G-quadruplex (GQ-2) near the alternative 5' splice site through its RE motif to promote the pro-apoptotic Bcl-xS isoform, recruiting U1 snRNP to the otherwise weak 5' splice site via association with hLuc7A (PMID:18663000, PMID:37811881). Its crystallized PWI domain and flanking basic region form a positively charged nucleic-acid-binding platform required in vivo for this splicing activity (PMID:23190262). Genome-wide, RBM25 is required for cell viability, interacts with early spliceosome components, and globally promotes alternative exon inclusion, an activity directly harnessed in the dCasRx-RBM25 programmable exon-inclusion tool (PMID:28655759, PMID:38917795). Through these splicing programs RBM25 acts as a tumor suppressor in AML by controlling BCL-X and BIN1 splicing to restrain MYC activity, governs macrophage metabolism via ACLY exon-14 skipping, and regulates cardiac function by reshaping SCN5A, MNK2, and MAP4K4 transcripts (PMID:21859973, PMID:30635567, PMID:39251781, PMID:39110401, PMID:41409803). RBM25 activity is itself regulated post-translationally by lysine-77 mono-methylation, which blocks high-affinity binding to the exon-definition factor SRSF2, and at the transcript level by METTL3-mediated m6A modification that stabilizes RBM25 mRNA (PMID:28655759, PMID:36762777). Beyond splicing, RBM25 occupies gene promoters to directly regulate transcription in embryonic stem cells and binds HBV cccDNA through its RE/RD and PWI domains to promote viral transcription (PMID:41455468, PMID:40412480). Conditional knockout establishes that Rbm25 is essential for murine hematopoiesis, with collapse of multiple lineages including long-term hematopoietic stem cells (PMID:41819468).

Mechanistic history

Synthesis pass · year-by-year structured walk · 20 steps
  1. 2008 High

    Established that RBM25 is a sequence-specific splicing regulator that activates a weak 5' splice site, answering how an exonic element directs apoptotic isoform choice.

    Evidence RNA binding, mutagenesis of the BCL-x CGGGCA element, U1 snRNP recruitment, and Co-IP with hLuc7A

    PMID:18663000

    Open questions at the time
    • hLuc7A interaction shown by single Co-IP without reciprocal validation
    • scope beyond BCL-x not yet defined at this stage
  2. 2011 High

    Extended RBM25's regulatory reach to cardiac ion channels, showing it drives truncation of SCN5A mRNA with functional consequences for sodium current.

    Evidence Gene array, overexpression in Jurkat and hESC-derived cardiomyocytes, mRNA/protein quantification, and electrophysiology

    PMID:21859973

    Open questions at the time
    • binding site on SCN5A not mapped
    • physiological trigger for this splicing not yet identified
  3. 2012 Medium

    Linked RBM25-mediated SCN5A splicing to pathophysiological signaling, showing heart-failure cues raise RBM25 levels and binding.

    Evidence RIP, qPCR, Western blot, and electrophysiology in cardiac cells treated with angiotensin II/hypoxia

    PMID:22939879

    Open questions at the time
    • single lab
    • upstream signaling connecting stimuli to RBM25 induction unresolved
  4. 2013 High

    Defined the structural basis of RBM25 nucleic-acid binding, showing the PWI domain plus flanking basic region forms an enlarged binding surface required for splicing function.

    Evidence X-ray crystallography, structure-guided mutagenesis, and in vivo Bcl-x splicing reporter

    PMID:23190262

    Open questions at the time
    • no co-structure with RNA
    • contribution of other RBM25 domains to specificity not resolved
  5. 2017 High

    Placed RBM25 in the global splicing machinery and uncovered methylation-based regulation, showing K77 mono-methylation blocks SRSF2 binding.

    Evidence shRNA viability assays, transcriptome-wide RNA-seq, quantitative proteomics, and methylated-peptide affinity binding for SRSF2

    PMID:28655759

    Open questions at the time
    • methyltransferase/demethylase acting on K77 not identified
    • functional output of SRSF2 displacement in vivo not quantified
  6. 2018 Medium

    Connected RBM25 to circular RNA biogenesis and p53 signaling, broadening its RNA-processing repertoire in cancer.

    Evidence RIP, p53 ChIP/reporter, circRNA perturbation with EMT readouts, and xenograft

    PMID:30531834

    Open questions at the time
    • circRNA is primary focus, RBM25 mechanism less developed
    • single lab
  7. 2019 High

    Defined RBM25 as a tumor suppressor in AML, showing its splicing of BCL-X and BIN1 restrains MYC-driven proliferation.

    Evidence In vivo shRNA screen in CEBPA-mutant AML, RT-PCR splicing analysis, and knockdown proliferation/apoptosis assays in multiple leukemic lines

    PMID:30635567

    Open questions at the time
    • direct BIN1 binding site not mapped
    • whether MYC effect is solely splicing-mediated unresolved
  8. 2023 High

    Resolved the RNA structural element underlying Bcl-xS production, showing RBM25's RE motif binds a G-quadruplex that is pharmacologically tractable.

    Evidence EMSA/pull-down with rG4, RE-motif mutagenesis, splicing reporters, and G4-ligand screening

    PMID:37811881

    Open questions at the time
    • generality of rG4 recognition across other RBM25 targets not established
  9. 2023 High

    Revealed a splicing-metabolism-epigenetic axis, showing RBM25 controls ACLY isoform choice to limit macrophage overactivation and autoimmunity.

    Evidence Macrophage-specific conditional KO, multiomics, RIP, arthritis model, and ACLY inhibitor rescue

    PMID:39251781

    Open questions at the time
    • RBM25 binding determinants on ACLY pre-mRNA not detailed
    • relevance to human inflammatory disease not tested
  10. 2023 Medium

    Identified upstream control of RBM25 abundance, showing METTL3-mediated m6A stabilizes RBM25 mRNA in multiple myeloma.

    Evidence MeRIP, METTL3 perturbation, mRNA stability assays, rescue, and xenograft

    PMID:36762777

    Open questions at the time
    • m6A reader mediating stabilization not identified
    • single lab
  11. 2023 Medium

    Established a stress-responsive pro-apoptotic role in cardiomyocytes via the CHOP pathway, with confirmed nuclear localization.

    Evidence Immunofluorescence, ER-tracker, siRNA knockdown in OGD and ischemic HF rat models, TUNEL, and echocardiography

    PMID:37736860

    Open questions at the time
    • mechanism linking RBM25 to CHOP not defined
    • splicing targets in this context not identified
  12. 2023 Medium

    Mapped additional cardiac splicing targets, expanding RBM25's role in cardiac inflammatory transcript processing.

    Evidence iRIP-seq, RNA-seq, and RT-qPCR validation in H9c2 cardiomyocytes

    PMID:37953772

    Open questions at the time
    • limited functional follow-up
    • phenotypic consequence of these splicing changes untested
  13. 2023 High

    Showed RBM25 controls MNK2 splicing to favor an oncogenic isoform, mechanistically validated by splice-switching rescue.

    Evidence iRIP-seq, RT-PCR splicing assays, shRNA knockdown, ASO rescue, and tumor growth assays

    PMID:39110401

    Open questions at the time
    • structural basis of poly-G recognition in MNK2 not resolved
  14. 2023 Medium

    Positioned Rbm25 within preleukemic clonal dynamics as a downstream mediator of Tet2 loss.

    Evidence Genetic barcoding in Tet2 KO mice with shRNA knockdown and colony assays

    PMID:36947858

    Open questions at the time
    • molecular effector linking Rbm25 to clonal expansion unknown
    • single lab
  15. 2024 High

    Demonstrated RBM25 is a portable exon-inclusion activator, repurposing its splicing function as a programmable tool.

    Evidence dCasRx-RBM25 fusion screen across >300 splicing factors with endogenous exon activation and transcriptome-wide specificity profiling

    PMID:38917795

    Open questions at the time
    • intrinsic domain conferring activator potency not dissected here
  16. 2025 Medium

    Defined a cardiac injury mechanism whereby RBM25-driven MAP4K4 splicing activates p38 MAPK/ERK signaling.

    Evidence Lentiviral OE/KD in rat LAD ligation model, qPCR, MAPK phospho-blots, TUNEL, and SB203580 rescue

    PMID:41409803

    Open questions at the time
    • isoform consequence partly computational
    • single lab
  17. 2025 Medium

    Uncovered a non-splicing role for RBM25 in viral chromatin, showing direct cccDNA binding promotes HBV transcription via YY1 and histone acetylation.

    Evidence ChIP on cccDNA, RE/RD and PWI domain mutagenesis, KD/OE in HBV models, and mouse hydrodynamic injection

    PMID:40412480

    Open questions at the time
    • mechanism of cccDNA/chromatin recruitment not fully defined
    • single lab
  18. 2025 Medium

    Showed RBM25 can be functionally sequestered by a decoy lncRNA, modulating SFPQ-dependent HOXB13 regulation in vascular cells.

    Evidence lncRNA pull-down, SFPQ RIP, knockdown proliferation assays, and in vivo GapmeR in PAH rat models

    PMID:40567228

    Open questions at the time
    • direct RBM25-SFPQ interaction interface not mapped
    • single lab
  19. 2025 Medium

    Revealed a transcriptional (non-splicing) role, showing Rbm25 occupies pluripotency-gene promoters to maintain ESC self-renewal.

    Evidence ChIP-seq promoter occupancy, Rbm25 KO/KD in ESCs, RNA-seq, and 2CLC reporter

    PMID:41455468

    Open questions at the time
    • how an RNA-binding protein is recruited to promoters unresolved
    • single lab
  20. 2026 High

    Established RBM25 as essential and haplosufficient for hematopoiesis, defining its in vivo requirement in stem cells.

    Evidence Conditional knockout mouse, bone marrow transplantation, and flow cytometry of hematopoietic lineages

    PMID:41819468

    Open questions at the time
    • splicing targets responsible for HSC collapse not identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RBM25 partitions between its splicing, promoter-transcriptional, and chromatin/cccDNA-binding functions—and what determines target selection in each—remains unresolved.
  • no unified model of recruitment to promoters vs. pre-mRNA
  • enzymes regulating K77 methylation not identified
  • in vivo splicing targets underlying organismal phenotypes largely undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 4 GO:0140098 catalytic activity, acting on RNA 3 GO:0003677 DNA binding 2
Localization
GO:0005634 nucleus 3
Pathway
R-HSA-5357801 Programmed Cell Death 3 R-HSA-8953854 Metabolism of RNA 3 R-HSA-74160 Gene expression (Transcription) 2
Partners
LUC7L3SFPQSRSF2
Complex memberships
spliceosome (early/U1 snRNP-associated)

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 RBM25 binds directly to a CGGGCA sequence within exon 2 of BCL-x pre-mRNA and stimulates proapoptotic Bcl-xS 5' splice site selection in a dose-dependent manner; mutation of the CGGGCA element abolished Bcl-xS isoform promotion. RBM25 binding promotes recruitment of U1 snRNP to the weak 5' splice site and is not required when a strong consensus 5' ss is present. RNA binding assay, site-directed mutagenesis of exonic element, U1 snRNP recruitment assay, dose-dependent overexpression/depletion experiments Molecular and cellular biology High 18663000
2008 RBM25 selectively associates with the human homolog of yeast U1 snRNP-associated factor hLuc7A, suggesting RBM25 stabilizes pre-mRNA-U1 snRNP interactions through hLuc7A to activate weak 5' splice site selection. Co-immunoprecipitation Molecular and cellular biology Medium 18663000
2011 RBM25 (together with LUC7L3) mediates truncation of SCN5A (cardiac sodium channel) mRNA in Jurkat cells and human embryonic stem cell-derived cardiomyocytes; overexpression of either splicing factor increased truncated SCN5A mRNA and decreased full-length SCN5A transcript and Na+ channel current by ~91%. Gene array, overexpression in Jurkat cells and hESC-derived cardiomyocytes, mRNA/protein quantification, electrophysiology Circulation High 21859973
2012 Angiotensin II and hypoxia (signals common to heart failure) increase LUC7L3 and RBM25 levels, resulting in increased RBM25 binding to SCN5A mRNA, increased SCN5A splice variants, and decreased full-length SCN5A mRNA, protein, and Na+ current. RIP (RNA immunoprecipitation), qPCR, Western blot, electrophysiology in cardiac cells treated with angiotensin II/hypoxia Trends in cardiovascular medicine Medium 22939879
2013 Crystal structure of the RBM25 PWI domain and its flanking basic region revealed a conserved four-helix bundle; the flanking basic region forms two alpha-helices that associate with helix H4 of the PWI domain, enlarging the nucleic-acid-binding platform. Structure-guided mutagenesis identified a positively charged nucleic-acid-binding surface distinct from SRm160 PWI domain. The PWI domain is required in vivo for promotion of pro-apoptotic Bcl-xS isoform expression. X-ray crystallography, structure-guided mutagenesis, in vivo splicing reporter assay The Biochemical journal High 23190262
2017 RBM25 is required for viability of multiple human cell lines and globally promotes inclusion of alternatively spliced exons across the human transcriptome. Proteomic analysis showed RBM25 interacts with components of the early spliceosome and regulators of alternative splicing. RBM25 is mono-methylated at lysine 77 (RBM25-K77me1); the region spanning K77 binds SRSF2 (crucial for exon definition) with high affinity only when K77 is unmethylated, providing a mechanism by which lysine methylation regulates RBM25 activity. shRNA knockdown viability assays, transcriptome-wide RNA-seq splicing analysis, quantitative mass spectrometry (proteomics), affinity binding assay for SRSF2 interaction with methylated vs. unmethylated peptides The Journal of biological chemistry High 28655759
2019 RBM25 controls alternative splicing of BCL-X (promoting pro-apoptotic Bcl-xS) and BIN1 (MYC inhibitor) in AML cells; knockdown of RBM25 promotes proliferation, decreases apoptosis, and increases MYC activity. RBM25 acts as a tumor suppressor in AML and was identified via in vivo shRNA screen in a mouse model of CEBPA-mutant AML. In vivo shRNA screen, splicing analysis by RT-PCR, knockdown in multiple human leukemic cell lines with proliferation/apoptosis assays Nature communications High 30635567
2018 RBM25 binds directly to circAMOTL1L RNA and induces its biogenesis; p53 activates RBM25 gene transcription, thereby regulating EMT via the circAMOTL1L-miR-193a-5p-Pcdha pathway in prostate cancer cells. RNA immunoprecipitation (RIP), p53 ChIP/reporter assay, circRNA overexpression/knockdown with EMT marker analysis, in vivo xenograft Oncogene Medium 30531834
2023 RBM25 directly and specifically binds to GQ-2, an RNA G-quadruplex (rG4) of BCL-x pre-mRNA located near the alternative 5' splice site for Bcl-xS, through its RE (arginine-glutamate-rich) motif; this RBM25/rG4 interaction is required for Bcl-xS production. G4 ligands (PhenDC3, PhenDH8, PhenDH9) that enhance RBM25 binding to GQ-2 promote Bcl-xS isoform and apoptosis. RNA binding assays (EMSA/pull-down with rG4), domain mutagenesis (RE motif), splicing reporter assays, ligand screening with G4-stabilizing compounds Nucleic acids research High 37811881
2023 RBM25 directly binds to ACLY pre-mRNA and mediates skipping of exon 14, generating two distinct Acly isoforms (Acly L and Acly S). In proinflammatory macrophages, Acly L (but not Acly S) undergoes protein lactylation at K918/K995, affecting metabolic substrate affinity. RBM25 deficiency shifts splicing toward Acly S, enhancing glycolysis and acetyl-CoA production for epigenetic remodeling and macrophage overactivation. Macrophage-specific RBM25 knockout leads to spontaneous arthritis in mice. RBM25 KO mice (conditional, macrophage-specific), multiomics (RNA-seq, proteomics, ChIP-seq), RIP, in vivo arthritis model, Acly inhibitor rescue Cellular & molecular immunology High 39251781
2023 METTL3-mediated m6A methylation of RBM25 mRNA stabilizes RBM25 mRNA and maintains its expression in multiple myeloma cells; metformin reduces METTL3 activity, thereby decreasing m6A on RBM25 mRNA and reducing RBM25 mRNA stability and expression. RBM25 knockdown reverses METTL3-overexpression-driven MM cell malignancy. MeRIP (m6A immunoprecipitation), METTL3 knockdown/overexpression, mRNA stability assay, rescue experiments, in vivo xenograft Cell cycle Medium 36762777
2023 RBM25 is localized to the nucleus in cardiomyocytes both in vitro and in vivo under hypoxia/ischemic conditions; ER stress stimulates RBM25 upregulation and promotes apoptosis via the CHOP signaling pathway. RBM25 knockdown blocks CHOP activation and reduces apoptosis, improving cardiac function. Immunofluorescence (nuclear localization), Western blot, ER-tracker, siRNA knockdown in OGD model and in vivo ischemic HF rat model, TUNEL, echocardiography Cell stress & chaperones Medium 37736860
2023 RBM25 binds to a poly-G-rich region in exon 14a of MNK2 pre-mRNA (shown by iRIP-seq and validated by RT-PCR), inhibiting the proximal 3' splice site and producing the oncogenic short isoform MNK2b. RBM25 depletion shifts splicing to the MNK2a isoform; re-expression of MNK2b or ASO-blocking of the alternative splice site rescues the tumor suppression from RBM25 knockdown. iRIP-seq, RNA-seq, RT-PCR splicing assays, shRNA knockdown, ASO rescue, in vitro and in vivo tumor growth assays Science China. Life sciences High 39110401
2023 RBM25 binds to Slc38a9, Csf1, and Coro6 mRNAs (identified by iRIP-seq) and regulates their alternative splicing in H9c2 cardiomyocytes, linking RBM25 to cardiac inflammatory responses. iRIP-seq, RNA-seq, RT-qPCR validation PeerJ Medium 37953772
2024 dCasRx fused to RBM25 (dCasRx-RBM25) functions as a potent activator of exon inclusion; it efficiently activates ~90% of targeted endogenous alternative exons with high on-target specificity, identified through screening >300 dCasRx-splicing factor fusion proteins. CRISPR-dCasRx fusion protein screen with splicing reporters, endogenous alternative exon activation assays, gRNA array combinatorial targeting, RNA-seq specificity analysis Molecular cell High 38917795
2025 RBM25 induces exon 16 skipping in MAP4K4 pre-mRNA (confirmed by qPCR), generating a truncated isoform predicted to enhance MAP3K1 binding and activate the p38 MAPK/ERK pathway; RBM25 overexpression exacerbates post-infarction heart failure via this MAP4K4 splicing-dependent MAPK activation, while RBM25 knockdown is cardioprotective. P38 MAPK inhibitor (SB203580) attenuated RBM25-mediated injury. Lentiviral OE/KD in rat LAD ligation model, qPCR, echocardiography, Western blot for MAPK phosphorylation, TUNEL, pharmacological rescue with SB203580 FASEB bioAdvances Medium 41409803
2025 RBM25 promotes HBV replication by binding to cccDNA through its RE/RD and PWI domains, upregulating Yin Yang 1 (YY1) expression, which enhances acetylation of cccDNA-bound histones to promote HBV transcription. HBV core protein accumulation causes nuclear translocation of RBM25, while RBM25 overexpression promotes core protein degradation, establishing a reciprocal regulatory loop. ChIP on cccDNA, domain deletion/mutagenesis (RE/RD and PWI), RBM25 KD/OE in HBV-replicating and infected cell models and mouse hydrodynamic injection model, promoter activity assays, histone acetylation assays Virologica Sinica Medium 40412480
2025 lnc-536 acts as a decoy for RBM25 in pulmonary artery smooth muscle cells; when lnc-536 is elevated, it sequesters RBM25 away from SFPQ (splicing factor proline/glutamine-rich), which in turn reduces SFPQ-HOXB13 mRNA interaction, decreasing HOXB13 expression and driving PASMC hyperproliferation. RBM25 knockdown increases SFPQ-HOXB13 mRNA interaction and attenuates PASMC proliferation. lncRNA pull-down, RNA immunoprecipitation (SFPQ antibody), RBM25 knockdown with proliferation assays, in vivo GapmeR antisense oligo in PAH rat models Arteriosclerosis, thrombosis, and vascular biology Medium 40567228
2025 Rbm25 occupies promoters of pluripotency- and DNA methylation-related genes in embryonic stem cells and directly regulates their transcription; deletion or depletion of Rbm25 impairs ESC self-renewal and promotes transition to 2-cell-like cells (2CLCs) by altering the epigenetic state of ESCs, revealing a transcriptional (non-splicing) regulatory role. ChIP-seq (promoter occupancy), Rbm25 knockout/knockdown in ESCs, RNA-seq, 2CLC reporter assay Stem cell reports Medium 41455468
2023 Rbm25 knockdown in vitro and in vivo accelerates clonal expansion of Tet2-knockout hematopoietic stem cells, placing Rbm25 as a downstream mediator of Tet2-loss-induced heterogeneous preleukemic clonal expansion. Genetic barcoding in conditional Tet2 KO mice, shRNA knockdown of Rbm25 in vitro and in vivo, hematopoietic colony assays Blood Medium 36947858
2026 Conditional (homozygous) knockout of Rbm25 in mice causes collapse of multiple hematopoietic lineages including long-term hematopoietic stem cells, demonstrating that Rbm25 is essential for normal murine hematopoiesis. Mono-allelic deletion does not impair HSC self-renewal even under proliferative stress, showing Rbm25 is haplosufficient. Conditional knockout mouse model, bone marrow transplantation, flow cytometry of hematopoietic lineages Experimental cell research High 41819468

Source papers

Stage 0 corpus · 29 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2018 Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway. Oncogene 156 30531834
2008 Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection. Molecular and cellular biology 117 18663000
2011 Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure. Circulation 79 21859973
2019 The splicing factor RBM25 controls MYC activity in acute myeloid leukemia. Nature communications 56 30635567
2017 RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation. The Journal of biological chemistry 51 28655759
2023 Indole-3-Lactic Acid, a Tryptophan Metabolite of Lactiplantibacillus plantarum DPUL-S164, Improved Intestinal Barrier Damage by Activating AhR and Nrf2 Signaling Pathways. Journal of agricultural and food chemistry 41 37996788
2008 The FF domains of yeast U1 snRNP protein Prp40 mediate interactions with Luc7 and Snu71. BMC biochemistry 33 19014439
2023 Metformin attenuates multiple myeloma cell proliferation and encourages apoptosis by suppressing METTL3-mediated m6A methylation of THRAP3, RBM25, and USP4. Cell cycle (Georgetown, Tex.) 32 36762777
2012 RBM25/LUC7L3 function in cardiac sodium channel splicing regulation of human heart failure. Trends in cardiovascular medicine 27 22939879
2023 Alternative splicing of BCL-x is controlled by RBM25 binding to a G-quadruplex in BCL-x pre-mRNA. Nucleic acids research 25 37811881
2024 RBM25 is required to restrain inflammation via ACLY RNA splicing-dependent metabolism rewiring. Cellular & molecular immunology 22 39251781
2017 Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer. Scientific reports 22 29209046
2024 Efficient, specific, and combinatorial control of endogenous exon splicing with dCasRx-RBM25. Molecular cell 21 38917795
2017 RBM25 Mediates Abiotic Responses in Plants. Frontiers in plant science 21 28344583
2023 RBM25 regulates hypoxic cardiomyocyte apoptosis through CHOP-associated endoplasmic reticulum stress. Cell stress & chaperones 15 37736860
2013 Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region. The Biochemical journal 14 23190262
2017 Human procaspase-2 phosphorylation at both S139 and S164 is required for 14-3-3 binding. Biochemical and biophysical research communications 13 28943433
2023 RBM25 induces trophoblast epithelial-mesenchymal transition and preeclampsia disorder by enhancing the positive feedback loop between Grhl2 and RBM25. Experimental biology and medicine (Maywood, N.J.) 9 37728157
2024 RBM25 depletion suppresses the growth of colon cancer cells through regulating alternative splicing of MNK2. Science China. Life sciences 5 39110401
2024 ZC3H13 may participate in the ferroptosis process of sepsis-induced cardiomyopathy by regulating the expression of Pnn and Rbm25. Gene 5 39284557
2023 RBM25 binds to and regulates alternative splicing levels of Slc38a9, Csf1, and Coro6 to affect immune and inflammatory processes in H9c2 cells. PeerJ 5 37953772
2023 RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice. Blood 4 36947858
2025 RBM25 Regulates p38 MAPK Pathway Activation via Exon 16 Skipping of MAP4K4 in a Rat Model of Post-Infarction Heart Failure. FASEB bioAdvances 2 41409803
2025 Host factor RBM25 promotes HBV replication through Yin Yang 1-mediated cccDNA transcription. Virologica Sinica 1 40412480
2025 LncRNA-536 and RNA-Binding Protein RBM25 Interactions in Pulmonary Artery Smooth Muscle Cells: Implications in Pulmonary Hypertension. Arteriosclerosis, thrombosis, and vascular biology 1 40567228
2024 LncRNA-536 and RNA Binding Protein RBM25 Interactions in Pulmonary Arterial Hypertension. bioRxiv : the preprint server for biology 1 39253448
2026 Loss of splicing factor RBM25 promotes the collapse of murine hematopoiesis. Experimental cell research 0 41819468
2026 Proteomic and transcriptomic analyses identify the role of RBM25 in the malignant progression of glioma. The International journal of neuroscience 0 42216302
2025 Rbm25 governs embryonic stem cell identity and fate through transcriptional regulation of pluripotency and epigenetic programs. Stem cell reports 0 41455468

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