Affinage

RANBP9

Ran-binding protein 9 · UniProt Q96S59

Length
729 aa
Mass
77.8 kDa
Annotated
2026-04-28
100 papers in source corpus 50 papers cited in narrative 50 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RANBP9 is a nucleocytoplasmic scaffold protein and core subunit of the CTLH E3 ubiquitin ligase complex that orchestrates diverse cellular processes—including receptor tyrosine kinase signaling, DNA damage response, apoptosis, integrin trafficking, and gametogenesis—by bridging cell-surface receptors, intracellular kinases, and protein quality-control machinery through its modular SPRY, LisH/CTLH, and N-terminal proline/glutamine-rich domains. Through its SPRY domain, RANBP9 interacts with numerous receptors (MET, Axl, TrkB, LFA-1, Plexin-A1, p75NTR) and intracellular effectors (TRAF6, HDAC6, c-Raf), functioning as a scaffold that recruits Sos to activate Ras-ERK signaling downstream of MET while independently inhibiting ERK via destabilization of c-Raf through displacement of Hsp90 (PMID:12147692, PMID:23118896). ATM phosphorylates RANBP9 at S181/S603 upon DNA damage, driving its nuclear translocation where it promotes homologous recombination repair and stabilizes p21 by recruiting the deubiquitinase USP11, and cooperates with p73 to activate mitochondria-mediated apoptosis through cofilin dephosphorylation and mitochondrial translocation (PMID:26943034, PMID:37676377, PMID:23348590, PMID:22361682). RANBP9 knockout mice are sterile due to meiotic arrest at pachytene-diplotene in both sexes, establishing an essential cell-autonomous role in gametogenesis (PMID:21561988).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 1998 High

    The initial discovery placed RANBP9 at the centrosome and linked it to microtubule nucleation via Ran-GTP, establishing it as a potential cytoskeletal regulator—though the protein studied was later shown to be a truncated isoform.

    Evidence Yeast two-hybrid with Ran-GTP, sucrose-gradient centrosomal fractionation, antibody inhibition of aster formation in mammalian cells

    PMID:9817760

    Open questions at the time
    • Centrosomal localization was later revised when full-length protein was characterized
    • Physiological relevance of Ran-GTP interaction at centrosomes not independently confirmed
  2. 2001 High

    Cloning of the full-length 90 kDa RANBP9 corrected the molecular identity, revealing it forms a >670 kDa complex and distributes across nucleus and cytoplasm rather than being exclusively centrosomal.

    Evidence cDNA cloning, gel filtration, co-IP, immunofluorescence with multiple antibodies

    PMID:11470507

    Open questions at the time
    • Identity of other subunits in the >670 kDa complex not yet known
    • Functional significance of nucleocytoplasmic distribution unclear
  3. 2002 High

    A burst of discoveries established RANBP9 as a multi-receptor scaffold: it bridges MET to Sos/Ras/ERK signaling via its N-terminal poly-PQ region, coactivates androgen and glucocorticoid receptors, and is itself regulated by USP11-mediated deubiquitination and proteasomal turnover.

    Evidence Yeast two-hybrid, GST pull-down, Ras-GTP loading, ERK phosphorylation, SRE-luciferase, in vitro deubiquitination reconstitution

    PMID:12084015 PMID:12147692 PMID:12361945

    Open questions at the time
    • Physiological contexts where MET-Sos scaffolding matters in vivo not established
    • E3 ligase responsible for RANBP9 ubiquitination not identified
  4. 2003 Medium

    Identification of Twa1 and Muskelin as RANBP9-associated proteins began to outline the multi-subunit complex later designated CTLH, while parallel work revealed interaction with neurotrophin receptor p75NTR.

    Evidence Yeast two-hybrid, co-IP, gel filtration for Twa1/Muskelin; two-hybrid and co-IP for p75NTR

    PMID:12559565 PMID:12963025

    Open questions at the time
    • Functional significance of CTLH complex not yet known
    • Whether p75NTR interaction is direct or bridged through other complex members
  5. 2005 High

    The SPRY domain emerged as the principal interaction module, mediating binding to L1-CAM, Axl/Tyro3, and p73; RANBP9 was shown to stabilize p73 by inhibiting its ubiquitination and to promote p73-dependent apoptosis, establishing a proapoptotic function.

    Evidence GST pull-down domain mapping, co-IP, neurite outgrowth assay, ubiquitination assay, apoptosis assay in multiple cell types

    PMID:15558019 PMID:15964779 PMID:16000162

    Open questions at the time
    • E3 ligase targeting p73 not identified
    • In vivo relevance of p73 stabilization not tested
  6. 2006 High

    RANBP9 was shown to mediate Semaphorin 3A signaling through Plexin-A1 in axonal guidance (loss- and gain-of-function), demonstrating its role as a signaling adaptor in neurodevelopment.

    Evidence Co-IP, siRNA knockdown reducing Sema3A responsiveness, overexpression inhibiting axonal outgrowth in vitro and in vivo

    PMID:16672672

    Open questions at the time
    • Downstream effectors linking RANBP9-PlexinA1 to cytoskeletal remodeling not identified
  7. 2007 High

    Mass spectrometry identified RANBP9 as a core subunit of the CTLH complex (with Muskelin, p48EMLP, p44CTLH, ARMC8α/β, Twa1), solving the identity of the large RANBP9-containing complex.

    Evidence Tandem MS with anti-RANBP9 antibody, reciprocal co-IP, GST pull-down with bacterially expressed Twa1

    PMID:17467196

    Open questions at the time
    • Enzymatic activity of the CTLH complex not yet demonstrated
    • Mammalian substrates unknown
  8. 2008 High

    Functional cooperation between RANBP9 and Muskelin within the CTLH complex was established: knockdown of either produced identical protrusive cell morphologies, and their localization was co-regulated, showing the complex acts as a unit in controlling cell shape.

    Evidence siRNA/shRNA knockdown with rescue, live cell microscopy, subcellular fractionation

    PMID:18710924

    Open questions at the time
    • Mechanism by which CTLH complex controls cell morphology not defined
    • Whether this involves HDAC6 or other effectors unknown at this point
  9. 2009 High

    RANBP9 was established as a scaffold promoting amyloidogenic APP processing by bridging APP, BACE1, and LRP, accelerating APP internalization into lipid rafts—and independently shown to activate caspase-dependent apoptosis upon DNA damage.

    Evidence Co-IP, lipid raft fractionation, Aβ ELISA, siRNA in primary neurons (APP); caspase assay, subcellular fractionation after IR (apoptosis)

    PMID:19251705 PMID:19996306

    Open questions at the time
    • Whether APP-scaffolding and apoptotic functions are linked or independent
    • In vivo validation in AD model pending
  10. 2011 High

    Knockout mice revealed that RANBP9 is essential for mammalian gametogenesis: both sexes are sterile with meiosis arrested at pachytene-diplotene, and chimera analysis proved cell-autonomous action in germ cells.

    Evidence Knockout mouse, histological meiotic staging, chimera analysis

    PMID:21561988

    Open questions at the time
    • Molecular mechanism of meiotic arrest not identified
    • Whether CTLH complex function is required for this role unknown
  11. 2012 High

    Bidirectional experiments showed RANBP9 disrupts integrin-dependent adhesion by accelerating β1-integrin endocytosis and suppressing focal adhesion signaling, while separately the cofilin pathway was identified as the effector of RANBP9-induced apoptosis.

    Evidence Cell attachment/spreading, surface biotinylation, endocytosis assay (integrin); cofilin siRNA epistasis rescuing apoptosis (cofilin)

    PMID:22223749 PMID:22361682

    Open questions at the time
    • How RANBP9 activates cofilin dephosphorylation mechanistically unclear
    • Whether integrin endocytosis and cofilin activation are coordinated
  12. 2013 High

    The RANBP9-p73 axis was validated as cooperative in mitochondrial apoptosis via bidirectional epistasis, and RANBP9 was found to suppress NF-κB signaling by binding TRAF6 and disrupting TRAF6 ubiquitination—extending its role to inflammatory signaling.

    Evidence Bidirectional siRNA (p73/RANBP9) with cytochrome c and apoptosis readouts; TRAF6 co-IP, NF-κB reporter, ubiquitination assay

    PMID:21805090 PMID:23348590

    Open questions at the time
    • Whether TRAF6 regulation involves CTLH complex E3 ligase activity or scaffolding alone
    • In vivo inflammatory phenotype not tested
  13. 2014 High

    In vivo genetic reduction of RANBP9 in APP/PS1 Alzheimer mice rescued cofilin-actin pathology, synaptic damage, and LTP deficits by normalizing SSH1 levels and cofilin activation, while a separate study identified RANBP9 as the essential bridge in the AXL-LRP1 efferocytosis complex in dendritic cells.

    Evidence APP/PS1 × RanBP9+/− mice with LTP electrophysiology and biochemistry (AD); DC-specific conditional deletion with in vivo efferocytosis and viral infection model (efferocytosis)

    PMID:24509082 PMID:25741591

    Open questions at the time
    • Whether SSH1 is a direct RANBP9 target or regulated indirectly
    • Substrate specificity of CTLH ligase in macrophage/DC context unknown
  14. 2014 High

    RANBP9 was shown to promote aggresome formation by binding and inhibiting HDAC6 deacetylase activity via its LisH/CTLH domain, connecting it to protein quality control pathways.

    Evidence Co-IP, HDAC6 deacetylase activity assay, domain deletion mutants, aggresome visualization

    PMID:24795145

    Open questions at the time
    • Whether CTLH complex members participate in aggresome regulation
    • Physiological triggers beyond IR not explored
  15. 2016 High

    The crystal structure of the RANBP9 SPRY domain revealed a β-sandwich fold that binds partners through a shallow conserved surface (KD ~13 μM for DDX-4), providing the first structural basis for its promiscuous receptor interactions. Separately, RANBP9 was shown to inhibit ERK by destabilizing c-Raf through displacement of Hsp90, establishing a tumor-suppressive mechanism.

    Evidence X-ray crystallography with ITC binding measurement and mutagenesis (structure); co-IP with Hsp90/c-Raf, ERK assay, migration assay (ERK inhibition); ATM phosphorylation mapping with HR repair assay (DDR)

    PMID:23118896 PMID:26943034 PMID:27622290

    Open questions at the time
    • Structure of full-length RANBP9 or CTLH complex not determined
    • How ATM-dependent phosphorylation alters SPRY domain interactions unknown
  16. 2017 High

    RANBP9 was found to stabilize tau protein by enhancing Hsp90/Hsc70 ATPase activity, with genetic reduction ameliorating tauopathy in Tau-P301S mice, and the CTLH complex was shown to collectively restrict cell migration by inhibiting HDAC6 tubulin deacetylase activity.

    Evidence In vitro ATPase assay, in vivo Tau-P301S cross with RanBP9 hemizygous (tau); HDAC6 acetylated-tubulin assay, wound healing, knockdown of multiple CTLH members (migration)

    PMID:28668087 PMID:29016855

    Open questions at the time
    • Whether tau stabilization is direct or entirely via Hsp90/Hsc70 modulation
    • Specific ubiquitin ligase substrates of CTLH complex still unidentified
  17. 2023 High

    The mechanism of RANBP9 in DNA damage response was refined: upon ATM-dependent nuclear translocation, RANBP9 recruits USP11 to deubiquitinate and stabilize p21, establishing a p21-dependent DDR pathway independent of p53 status.

    Evidence Co-IP, in vivo ubiquitylation assay, ATM inhibitor, p21-dependent functional rescue across multiple cell lines

    PMID:37676377

    Open questions at the time
    • Whether p21 stabilization and HR repair promotion are the same or parallel nuclear functions
    • In vivo tumor suppressor role via p21 not tested
  18. 2025 Medium

    Unbiased in vivo proteomics and ubiquitylome studies confirmed RANBP9 as a CTLH complex core subunit in lung macrophages and NSCLC cells, and showed RANBP9 and its paralog RANBP10 act as partial antagonists modulating CTLH E3 ligase output and cell proliferation.

    Evidence Dual-tag co-IP/MS in conditional mouse model (macrophage); inducible overexpression/loss-of-function with ubiquitylome MS in NSCLC cells

    PMID:40223093 PMID:40883813

    Open questions at the time
    • Individual validated substrates of the CTLH complex in mammals remain largely uncharacterized
    • How RANBP9/RANBP10 ratio is regulated physiologically unknown
    • Whether CTLH E3 ligase activity contributes to known RANBP9 phenotypes (gametogenesis, DDR, neurodegeneration) remains untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major open questions include: the identity of specific mammalian CTLH complex ubiquitin ligase substrates, the structure of full-length RANBP9 and the assembled CTLH complex, how ATM phosphorylation mechanistically alters RANBP9 interactions, and whether the meiotic arrest in knockout mice reflects CTLH ligase activity or scaffolding functions.
  • No validated individual CTLH ubiquitin ligase substrates in mammals
  • No full-length RANBP9 or CTLH holocomplex structure
  • Mechanistic link between ATM phosphorylation and altered protein-protein interactions not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0098772 molecular function regulator activity 4 GO:0008092 cytoskeletal protein binding 3 GO:0140110 transcription regulator activity 2
Localization
GO:0005634 nucleus 4 GO:0005829 cytosol 2 GO:0005886 plasma membrane 2 GO:0005815 microtubule organizing center 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-392499 Metabolism of proteins 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-1266738 Developmental Biology 2 R-HSA-168256 Immune System 2 R-HSA-73894 DNA Repair 2 R-HSA-1474165 Reproduction 1
Partners
ARMC8HDAC6METMKLN1TP73TRAF6TWA1USP11
Complex memberships
AXL-RANBP9-LRP1 efferocytosis complexCTLH complex

Evidence

Reading pass · 50 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 RanBPM (RANBP9) localizes to the centrosome throughout the cell cycle, cosediments with centrosomal fractions by sucrose-density gradient centrifugation, and specifically interacts with GTP-Ran in two-hybrid assay. Overexpression causes ectopic microtubule nucleation sites colocalizing with gamma-tubulin, and anti-RanBPM antibodies inhibit microtubule aster formation. Yeast two-hybrid, sucrose-density gradient centrifugation, immunofluorescence, antibody inhibition assay The Journal of cell biology High 9817760
2001 Full-length RanBPM encodes a 90 kDa protein (not 55 kDa) that forms a large protein complex of >670 kDa and localizes predominantly to both nucleus and cytoplasm surrounding the centrosome, not exclusively centrosomal as previously thought. Ran is detected in this complex when both are co-expressed. cDNA cloning, immunoprecipitation, gel filtration, immunofluorescence with multiple antibodies Gene High 11470507
2002 RanBPM/RanBP9 interacts with the tyrosine kinase domain of MET receptor via its SPRY domain, both in vitro and in vivo, and this interaction is strengthened by HGF stimulation. RanBPM activates the Ras-Erk-SRE pathway by recruiting Sos to MET, and its N-terminal poly-PQ region is required for Sos recruitment. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, Ras-GTP loading assay, ERK phosphorylation assay, SRE-luciferase reporter The Journal of biological chemistry High 12147692
2002 RanBPM interacts with the androgen receptor (AR) and glucocorticoid receptor (GR) but not estrogen receptor, and overexpression of RanBPM enhances AR and GR transcriptional activity in a ligand-dependent fashion. Yeast two-hybrid, GST pull-down, His-tag pull-down, transient transfection reporter assay in prostate cancer cell lines The Journal of biological chemistry High 12361945
2002 RanBPM is ubiquitinated and undergoes proteasome-dependent degradation; it is a substrate for the deubiquitinase USP11, which directly interacts with RanBPM and inhibits its ubiquitination in a dose-dependent manner. Yeast two-hybrid, co-immunoprecipitation, pulse-chase with proteasome inhibitors, in vivo and in vitro ubiquitination assay, recombinant USP11 deubiquitination assay The Biochemical journal High 12084015
2003 RanBPM forms a protein complex with Twa1 and Muskelin as identified by yeast two-hybrid and confirmed by co-immunoprecipitation and gel-filtration analysis. Yeast two-hybrid, co-immunoprecipitation, gel filtration Gene Medium 12559565
2003 RanBPM interacts with the death domain of the p75 neurotrophin receptor (p75NTR) intracellular domain, as shown by yeast two-hybrid and co-immunoprecipitation in mammalian cells. Yeast two-hybrid, co-immunoprecipitation, domain mapping Biochemical and biophysical research communications Medium 12963025
2004 RanBPM is a peripheral membrane protein phosphorylated on serine residues; phosphorylation is increased by stress stimuli and decreased by p38 kinase inhibitor SB203580. RanBPM interacts with the cytoplasmic domain of beta2 integrin LFA-1 and beta1 integrin in vitro and in vivo, co-localizes at the cell membrane, and synergizes with LFA-1 in AP-1-dependent transcriptional activation. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, immunofluorescence co-localization, AP-1 reporter assay, p38 inhibitor treatment The Journal of biological chemistry High 14722085
2004 RanBP10, a paralog of RanBPM/RanBP9, interacts with MET via its SPRY domain but fails to recruit Sos and cannot activate Ras/Erk signaling, demonstrating that the N-terminal poly-PQ region of RanBPM is required for Sos recruitment and Ras/Erk pathway activation. Co-transfection, SRE-luciferase reporter, ERK phosphorylation, binding assay, domain deletion mutants Biochemical and biophysical research communications Medium 14684163
2005 RanBPM interacts with the neural cell adhesion molecule L1 via its N-terminal SPRY domain both in vivo and in GST pull-down assays. Overexpression of N-terminal RanBPM (N-RanBPM) reduces L1-triggered ERK1/2 activation by 50% and inhibits L1-mediated neurite outgrowth and branching in primary neurons. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, L1 antibody patching, ERK phosphorylation assay, neurite outgrowth assay in primary neurons Journal of neurochemistry High 16000162
2005 RanBPM directly binds to the extreme C-terminal region of p73alpha but not p53, inhibits ubiquitination of p73alpha, extends its half-life, induces nuclear co-localization of both proteins, and enhances p73alpha proapoptotic activity. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, immunofluorescence, ubiquitination assay, apoptosis assay Oncogene High 15558019
2005 RanBPM interacts with the Axl and Sky/Tyro3 receptor tyrosine kinases; the SPRY-LisH domain region of RanBPM is required for this interaction, and endogenous Axl and RanBPM constitutively interact in multiple mammalian cell lines. Yeast two-hybrid, co-immunoprecipitation (cell-free and mammalian), domain deletion analysis The international journal of biochemistry & cell biology Medium 15964779
2006 RanBPM physically interacts with Plexin-A1 and this complex is regulated by MICAL expression. Overexpression of RanBPM with PlexinA1 reduces cell spreading and strongly inhibits axonal outgrowth; truncated RanBPM or RanBPM siRNA knockdown reduces Sema3A responsiveness, establishing RanBPM as a mediator of Sema3A signaling through Plexin-A. Yeast two-hybrid, co-immunoprecipitation, cell spreading assay, axonal outgrowth assay in vitro and in vivo, siRNA knockdown The Journal of neuroscience High 16672672
2006 RanBPM interacts with the N-terminus of CD39/ecto-NTPDase1 via its SPRY domain and co-expression of RanBPM substantially diminishes NTPDase activity of recombinant CD39 in COS-7 cells; an N-terminus-deleted CD39 mutant shows no inhibition. Yeast two-hybrid, co-immunoprecipitation, NTPDase activity assay, domain deletion mutants The Biochemical journal Medium 16478441
2006 RanBPM acts as a coactivator for thyroid hormone receptors (TRs) in a ligand-independent manner; the C-terminal region of RanBPM mediates binding to the TR DNA-binding domain, and the N-terminal polyglutamine region of RanBPM is required for stimulating TR transactivation. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, luciferase reporter assay, domain deletion analysis Journal of molecular endocrinology Medium 16595702
2007 RanBPM is a core component of the CTLH complex, which includes Muskelin, p48EMLP, p44CTLH, ARMC8alpha, and ARMC8beta; each component was confirmed by co-immunoprecipitation in Cos-7 cells and pull-down with bacterially expressed Twa1. Tandem MS with anti-RanBPM antibody, co-immunoprecipitation, GST pull-down with bacterially expressed Twa1, in vitro translation Gene High 17467196
2008 RanBPM interacts with EBV immediate-early protein Rta via the SPRY domain of RanBPM; this interaction promotes sumoylation of Rta by SUMO-E2 (Ubc9), which enhances Rta transactivation activity of viral lytic genes. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, confocal microscopy, sumoylation assay, luciferase reporter Journal of molecular biology Medium 18455188
2008 Muskelin subcellular localization is coregulated with RanBP9; knockdown of either muskelin or RanBP9 results in protrusive cell morphologies with enlarged cell perimeters. Muskelin's C-terminus controls both cytoplasmic restraint and RanBP9 interaction. RanBP9 knockdown produces equivalent morphological alterations to muskelin knockdown. Subcellular fractionation, siRNA/shRNA knockdown, rescue with cDNA constructs, live cell microscopy The Journal of cell biology High 18710924
2008 RanBPM interacts with metabotropic glutamate receptors mGlu2, and other group II and group III receptors (except mGlu6), and is expressed in the inner plexiform layer of the retina co-localizing with mGlu8b. Yeast two-hybrid screen, co-immunoprecipitation, immunofluorescence co-localization FEBS letters Medium 18555800
2008 RanBPM modulates Cav3.1 T-type Ca2+ channel currents; it binds to the intracellular loop between transmembrane domains I and II of Cav3.1, increases Cav3.1 currents in whole-cell patch-clamp, and abolishes PKC-mediated inhibition of Cav3.1 currents. Yeast two-hybrid, co-immunoprecipitation, whole-cell patch-clamp electrophysiology, PKC activator treatment Biochemical and biophysical research communications Medium 18801335
2009 RanBPM/RanBP9 promotes BACE1 cleavage of APP and Abeta generation by scaffolding APP, LRP, and BACE1 together via its N-terminal SPRY-LisH domains; it reduces cell surface APP, accelerates APP internalization, and increases APP association with lipid rafts. siRNA knockdown of endogenous RanBP9 significantly reduces Abeta generation in CHO cells and primary neurons. Co-immunoprecipitation, cell surface biotinylation, internalization assay, lipid raft fractionation, Abeta ELISA, siRNA knockdown in primary neurons The Journal of biological chemistry High 19251705
2009 RanBPM functions as an activator of apoptotic pathways induced by DNA damage: transient RanBPM expression induces caspase activation; siRNA knockdown of RanBPM prevents DNA damage-induced caspase-3 and caspase-2 activation. Following ionizing radiation, RanBPM relocalizes progressively from nucleus to cytoplasm, and RanBPM downregulation is associated with decreased mitochondria-associated Bax and upregulated Bcl-2. Transient transfection, siRNA knockdown, caspase activation assay, cell viability assay, subcellular fractionation, Western blot, ionizing radiation treatment Molecular cancer research : MCR Medium 19996306
2009 RanBPM constitutively associates with mu opioid receptor (MOP) and reduces agonist-induced endocytosis of MOP by interfering with beta-arrestin2 translocation, without affecting MOP-mediated inhibition of adenylyl cyclase. Yeast two-hybrid, co-immunoprecipitation in HEK293 cells, adenylyl cyclase inhibition assay, receptor internalization assay, beta-arrestin2-GFP translocation assay Neuroscience letters Medium 19788913
2010 RanBPM interacts with citron kinase (CITK) and co-localizes at adherens junctions in developing neocortex. In utero RNAi knockdown of RanBPM decreases CITK polarization at the ventricular surface, increases cells in mitosis, decreases cells in cytokinesis, and the mitosis effect is reversed in CITK-mutant embryos (epistasis). Yeast two-hybrid, co-immunoprecipitation, protein overlay, in utero RNAi, genetic epistasis with CITK mutants, immunofluorescence Developmental neurobiology High 19790105
2010 RanBPM interacts with TrkB receptor and overexpression enhances BDNF-induced MAPK and Akt activation; siRNA knockdown of RanBPM reduces BDNF-induced MAPK and Akt activation, neuronal morphogenesis, and BDNF-mediated trophic effects. Co-immunoprecipitation, ERK/Akt phosphorylation assay, neuronal morphogenesis assay, siRNA knockdown Journal of neurochemistry Medium 20403074
2011 RanBPM is essential for mammalian gametogenesis: RanBPM knockout mice are sterile in both sexes, with spermatogenesis arrested at late pachytene-diplotene stages of prophase I and premature ovarian failure due to depletion of germ cell pool at end of prophase I. Chimeric mice show cell-autonomous action of RanBPM in germ cells. Knockout mouse generation, histological analysis, chimera analysis, meiotic staging Development (Cambridge, England) High 21561988
2012 RanBPM overexpression disrupts integrin-dependent cell attachment and spreading, decreases Pyk2/paxillin signaling and talin/vinculin localization at focal adhesions, and accelerates endocytosis of beta1-integrin and LRP. Conversely, RanBP9 knockdown promotes cell attachment, spreading, focal adhesion signaling, and increases surface beta1-integrin. Cell attachment/spreading assay, focal adhesion immunostaining, Pyk2/paxillin phosphorylation assay, cell surface biotinylation, endocytosis assay, siRNA knockdown, transgenic primary neurons FASEB journal High 22223749
2012 RanBP9 overexpression promotes apoptosis and potentiates Abeta-induced neurotoxicity by activating/dephosphorylating cofilin; siRNA knockdown of cofilin abolishes both Abeta- and RanBP9-induced apoptosis, establishing the RanBP9-cofilin pathway as a mediator of neurodegeneration. Transgenic mouse overexpression, siRNA knockdown, cofilin phosphorylation assay, apoptosis assay, neurotoxicity assay Cell death and differentiation High 22361682
2013 RanBPM interacts with the TRAF6 C-terminus via its SPRY domain, influences TRAF6 ubiquitination, and depresses the TRAF6-triggered NF-kappaB signaling pathway. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, FRET, NF-kB reporter assay, ubiquitination assay Molecular and cellular biochemistry Medium 21805090
2013 RanBP9 physically interacts with p73 and increases endogenous p73alpha levels at both transcriptional and post-translational levels; knockdown of p73 by siRNA blocks RanBP9- and Abeta-induced mitochondria-mediated cell death, and knockdown of RanBP9 suppresses p73-induced apoptosis, demonstrating cooperative roles. Co-immunoprecipitation, siRNA knockdown (bidirectional epistasis), mitochondrial membrane potential assay, cytochrome c release assay, apoptosis assay Cell death & disease High 23348590
2013 RanBP9 delays clearance of cytosolic Ca2+ mediated by the mitochondrial calcium uniporter through cofilin translocation to mitochondria and oxidative mechanisms; RanBP9 also retards anterograde axonal transport of mitochondria and decreases synaptic mitochondrial activity. Calcium imaging, ROS measurement, mitochondrial transport assay, cofilin localization assay in primary hippocampal neurons FASEB journal Medium 23982146
2013 RanBPM interacts with TGF-beta receptor I (TbetaRI) and abrogates TbetaRI-TRAF6 interaction; RanBPM depresses TGF-beta-induced TRAF6 ubiquitination, NF-kappaB signaling, and blocks TbetaRI nuclear accumulation. Yeast two-hybrid, co-immunoprecipitation, GST pull-down, TbetaRI nuclear localization assay, NF-kB reporter, ubiquitination assay Cellular signalling Medium 24103590
2013 COPS5/Jab1 interacts with RanBP9, stabilizes RanBP9 protein by extending its half-life, and thereby increases Abeta generation; siRNA knockdown of COPS5 reduces Abeta generation. Yeast two-hybrid, co-immunoprecipitation, protein stability (half-life) assay, Abeta ELISA, siRNA knockdown The Journal of biological chemistry Medium 23926111
2014 RanBP9 positively regulates SSH1 (Slingshot homolog 1) levels and mediates Abeta-induced translocation of cofilin to mitochondria and induction of cofilin-actin pathology in cells, primary neurons, and in vivo; RanBP9 reduction in APP/PS1 mice protects against cofilin-actin pathology, synaptic damage, gliosis, and Abeta accumulation, and significantly enhances LTP. Western blot for SSH1 levels, cofilin localization assay, cofilin-actin rod assay, siRNA knockdown, in vivo genetic reduction (APP/PS1 x RanBP9 hemizygous), LTP electrophysiology, behavioral memory test Cell death & disease High 25741591
2014 AXL and LRP-1 do not interact directly but rely on RANBP9, which binds both AXL and LRP-1, to form a tripartite complex that mediates DC efferocytosis; AXL binds apoptotic cells while LRP-1 triggers internalization. Targeted deletion of DC-specific LRP-1, AXL, or RANBP9 in mice increases AC accumulation, impairs viral antigen CD8+ T cell activation, and decreases survival. Co-immunoprecipitation, targeted genetic deletion in mice, in vivo spleen efferocytosis assay, antigen cross-presentation coculture assay, HSV-1 infection model The Journal of clinical investigation High 24509082
2014 RanBPM promotes aggresome formation through interaction with HDAC6 and inhibition of its deacetylase activity; IR promotes RanBPM relocalization to aggresomes where it colocalizes with ubiquitin, dynein, and HDAC6. RanBPM deletion (LisH/CTLH domain) prevents both HDAC6 interaction and aggresome formation. Co-immunoprecipitation, HDAC6 deacetylase activity assay, confocal co-localization, shRNA knockdown, domain deletion mutants, aggresome formation assay Biology open High 24795145
2014 RanBPM interacts with Tip60 histone acetyltransferase; this interaction dramatically relocalizes RanBPM to nuclear speckles, redirects AICD away from transcription factories, and has a negative effect on AICD-mediated nuclear signaling and AFT complex formation, reducing expression of AICD-regulated genes. Co-immunoprecipitation, confocal microscopy, reporter gene assay, nuclear spot formation assay Journal of Alzheimer's disease : JAD Medium 25024339
2015 RanBPM subcellular localization is controlled by: (1) a dominant N-terminal proline/glutamine-rich motif conferring nuclear localization; (2) a C-terminal motif minimally contributing nuclear targeting; (3) a nuclear export signal (NES) whose mutation prevents cytoplasmic accumulation; and (4) cytoplasmic retention via protein-protein interactions through SPRY and LisH/CTLH domains. In the cytoplasm, RanBPM partially colocalizes with and associates with alpha-tubulin; in the nucleus it associates with chromatin. Systematic deletion/mutation analysis in RanBPM shRNA background, immunofluorescence, subcellular fractionation, co-immunoprecipitation with alpha-tubulin, chromatin association assay PloS one High 25659156
2015 RanBPM (RanBPM55 isoform) binds Zta of EBV; acts as intermediary in Rta-Zta complex formation; enhances Zta-dependent transcriptional activity via inhibition of Zta sumoylation; RanBPM shRNA reduces synergistic activity of Zta and Rta and inhibits expression of lytic proteins. Co-immunoprecipitation, GST pull-down, luciferase reporter, sumoylation assay, shRNA knockdown The Journal of general virology Medium 25900136
2016 RanBPM is an inhibitor of ERK signaling: RanBPM knockdown stimulates ERK phosphorylation and Bcl-2 upregulation; RanBPM inhibits MEK/ERK activation by active RasV12 and c-Raf, forms a complex with active c-Raf (via its C-terminal kinase domain), decreases binding of Hsp90 to c-Raf, and reduces endogenous c-Raf protein levels. Loss of RanBPM increases cell proliferation and migration. siRNA/shRNA knockdown, ERK phosphorylation assay, Ras activation assay, co-immunoprecipitation with c-Raf and Hsp90, cell proliferation and migration assay PloS one High 23118896
2016 RanBPM crystal structure of the IUS-SPRY domain (including ~70 upstream residues) was determined; it forms a beta-sandwich fold with flanking helices. The SPRY domain surface binds a 20-mer peptide of DDX-4 (residues 228-247) with KD ~13 μM via a shallow binding surface formed by conserved loops, and mutagenesis identifies critical residues for this interaction. X-ray crystallography, isothermal titration calorimetry/binding assay, site-directed mutagenesis Journal of molecular biology High 27622290
2016 RanBPM binds c-Kit receptor and is necessary for normal c-Kit protein expression in mouse testis and hematopoietic lineages; RanBPM deletion reduces c-Kit protein but not mRNA, indicating post-translational regulation specific to c-Kit. Co-immunoprecipitation, knockout mouse analysis, protein and mRNA quantification (Western blot and RT-PCR) Oncotarget Medium 27835883
2016 RanBP9/TSSC3 complex, formed via RanBP9 SPRY domain and TSSC3 PH domain, forms a ternary complex with Src that suppresses both Src and Src-dependent Akt pathway activations, promotes anoikis, and suppresses metastasis in vivo. Co-immunoprecipitation, domain interaction mapping, Src/Akt activity assay, anoikis assay, anchorage-independent growth assay, in vivo metastasis model Cell death & disease Medium 28032865
2016 ATM kinase phosphorylates RanBP9 on at least two residues (S181 and S603) in response to ionizing radiation; this promotes nuclear accumulation of RanBP9 in an ATM-dependent manner. RanBP9 silencing delays activation of ATM, Chk2, gamma-H2AX, and p53, and reduces homologous recombination-dependent DNA repair efficiency. Phosphorylation mapping, ATM inhibition, subcellular fractionation, siRNA knockdown, HR repair assay, gamma-H2AX foci analysis Oncotarget High 26943034
2017 RanBP9 physically interacts with tau and with Hsp90/Hsc70 chaperone complexes; RanBP9 overexpression or knockdown directly increases or decreases tau levels in vitro and in vivo. RanBP9 enhances ATPase activities of Hsp90 and Hsc70 in vitro, and counteracts anti-tau efficacy of Hsp90/Hsc70 inhibitors. Genetic RanBP9 reduction ameliorates tauopathy in Tau-P301S mice. Co-immunoprecipitation, ATPase activity assay in vitro, overexpression/knockdown with tau quantification, Hsp90/Hsc70 inhibitor treatment, in vivo Tau-P301S mouse model with synaptic and plasticity readouts Human molecular genetics High 29016855
2017 RanBPM, together with the CTLH complex members (muskelin, Twa1, MAEA, Rmnd5A), associates with HDAC6 and restricts cell migration through inhibition of HDAC6 alpha-tubulin deacetylase activity; RanBPM association with microtubules requires HDAC6; increased cell migration from RanBPM loss is due to relief of HDAC6 inhibition. Co-immunoprecipitation, HDAC6 deacetylase activity assay (acetylated alpha-tubulin levels), wound healing migration assay, confocal microscopy, shRNA knockdown of multiple CTLH members BMC cancer High 28668087
2017 CLOCK interacts with RANBP9 in mouse testis (validated by co-immunoprecipitation in vitro and in vivo); RANBP9 also interacts with the spliceosome component SF3B3, and CLOCK interacts with SF3B3, suggesting RANBP9 mediates CLOCK's involvement in alternative splicing during spermatogenesis. Yeast two-hybrid, co-immunoprecipitation in vitro and in mouse testis, RNA-immunoprecipitation followed by high-throughput sequencing (RIP-Seq) Gene Medium 29126923
2023 RanBPM physically interacts with p21 protein, deubiquitinates p21 by recruiting USP11 to maintain p21 protein stability, and translocates to the nucleus upon DNA damage in an ATM-dependent manner. RanBPM knockdown decreases p21 levels; overexpression increases p21 regardless of p53 status. RanBPM regulates DDR in a p21-dependent manner. Co-immunoprecipitation, in vivo ubiquitylation assay, protein stability assay, ATM inhibitor treatment, nuclear translocation analysis, p21-dependent functional rescue Cellular oncology High 37676377
2025 In lung macrophages in vivo, RanBP9 is co-immunoprecipitated with all known CTLH complex members; the lung RanBP9-associated proteome includes macrophage-specific proteins and players in innate immune response, DNA damage response, metabolism, and mitochondrial function, revealing CTLH-complex-dependent and independent interactors. In vivo mouse model (RanBP9-TurnX x LysM-Cre), dual-tag co-immunoprecipitation with mass spectrometry, comparative proteomics Cell death discovery Medium 40223093
2025 RANBP9 and RANBP10 independently support formation of the CTLH complex E3 ligase; they balance each other's expression, and acute overexpression of either reshapes the NSCLC cell proteome and ubiquitylome. Higher RANBP9/RANBP10 ratio associates with greater proliferation. RANBP9 and RANBP10 act as partial antagonists modulating CTLH complex ubiquitylation output. Inducible overexpression and loss-of-function cell lines, proteomics, ubiquitylome mass spectrometry, cell proliferation assay Journal of experimental & clinical cancer research Medium 40883813

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin. The Journal of cell biology 165 9817760
2002 Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. The Journal of biological chemistry 127 12147692
2007 RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex. Gene 105 17467196
2014 An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. The Journal of clinical investigation 101 24509082
2001 Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex. Gene 97 11470507
2004 RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1. The Journal of biological chemistry 83 14722085
2002 RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor. The Journal of biological chemistry 83 12361945
2002 Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. The Biochemical journal 77 12084015
2009 Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation. The Journal of biological chemistry 76 19251705
2005 RanBPM is an L1-interacting protein that regulates L1-mediated mitogen-activated protein kinase activation. Journal of neurochemistry 76 16000162
2007 RanBPM, a scaffolding protein in the immune and nervous systems. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 71 18040864
2006 RanBPM contributes to Semaphorin3A signaling through plexin-A receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 69 16672672
2012 Pivotal role of the RanBP9-cofilin pathway in Aβ-induced apoptosis and neurodegeneration. Cell death and differentiation 67 22361682
2015 RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction. Cell death & disease 65 25741591
2013 Molecular phylogeny of a RING E3 ubiquitin ligase, conserved in eukaryotic cells and dominated by homologous components, the muskelin/RanBPM/CTLH complex. PloS one 64 24143168
2005 Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells. Oncogene 63 15558019
2003 A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM. Gene 61 12559565
2013 Cooperative role of RanBP9 and P73 in mitochondria-mediated apoptosis. Cell death & disease 58 23348590
2010 YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10. Genomics 57 20580816
2008 Novel role of the muskelin-RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation. The Journal of cell biology 56 18710924
2009 A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 55 19729516
2006 RanBPM associates with CD39 and modulates ecto-nucleotidase activity. The Biochemical journal 55 16478441
2002 RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer. BMC cancer 54 12421467
2005 A specific role for the TFIID subunit TAF4 and RanBPM in neural progenitor differentiation. Molecular and cellular neurosciences 46 15911349
2012 Pivotal role of RanBP9 in integrin-dependent focal adhesion signaling and assembly. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 44 22223749
2009 RanBPM has proapoptotic activities that regulate cell death pathways in response to DNA damage. Molecular cancer research : MCR 43 19996306
2008 Enhancement of transactivation activity of Rta of Epstein-Barr virus by RanBPM. Journal of molecular biology 40 18455188
2011 RanBPM is essential for mouse spermatogenesis and oogenesis. Development (Cambridge, England) 39 21561988
2005 The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases. The international journal of biochemistry & cell biology 39 15964779
2004 A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. Biochemical and biophysical research communications 38 14684163
2003 RanBPM is a novel binding protein for p75NTR. Biochemical and biophysical research communications 38 12963025
2014 A lentiviral sponge for miR-101 regulates RanBP9 expression and amyloid precursor protein metabolism in hippocampal neurons. Frontiers in cellular neuroscience 37 24592211
2011 Diverse roles of the scaffolding protein RanBPM. Drug discovery today 35 22094242
2017 Cell signalling pathway regulation by RanBPM: molecular insights and disease implications. Open biology 34 28659384
2004 Mouse RanBPM is a partner gene to a germline specific RNA helicase, mouse vasa homolog protein. Molecular reproduction and development 33 14648869
2002 HIPK2 associates with RanBPM. Biochemical and biophysical research communications 33 12220523
2010 Stability and function of mammalian lethal giant larvae-1 oncoprotein are regulated by the scaffolding protein RanBPM. The Journal of biological chemistry 32 20829363
2003 The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM. Biochemical and biophysical research communications 32 14511641
2013 Mitochondrial dysfunction and calcium deregulation by the RanBP9-cofilin pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31 23982146
2012 Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 30 22294787
2010 RanBPM regulates the progression of neuronal precursors through M-phase at the surface of the neocortical ventricular zone. Developmental neurobiology 30 19790105
2017 Enhanced tau pathology via RanBP9 and Hsp90/Hsc70 chaperone complexes. Human molecular genetics 29 29016855
2016 RanBP9/TSSC3 complex cooperates to suppress anoikis resistance and metastasis via inhibiting Src-mediated Akt signaling in osteosarcoma. Cell death & disease 29 28032865
2012 Interactions of an Arabidopsis RanBPM homologue with LisH-CTLH domain proteins revealed high conservation of CTLH complexes in eukaryotes. BMC plant biology 29 22676313
2006 Identification and characterization of RanBPM, a novel coactivator of thyroid hormone receptors. Journal of molecular endocrinology 29 16595702
2006 The Ran binding protein RanBPM interacts with TrkA receptor. Neuroscience letters 29 16959415
2014 Aggresome formation is regulated by RanBPM through an interaction with HDAC6. Biology open 28 24795145
2008 RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors. FEBS letters 27 18555800
2008 RanBPM regulates cell shape, arrangement, and capacity of the female germline stem cell niche in Drosophila melanogaster. The Journal of cell biology 27 18762575
2010 RanBPM contributes to TrkB signaling and regulates brain-derived neurotrophic factor-induced neuronal morphogenesis and survival. Journal of neurochemistry 26 20403074
2016 Ran Binding Protein 9 (RanBP9) is a novel mediator of cellular DNA damage response in lung cancer cells. Oncotarget 25 26943034
2013 RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes. Cell death & disease 25 23764848
2021 Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/XIAP axis. Bioengineered 23 34546853
2012 RanBPM expression regulates transcriptional pathways involved in development and tumorigenesis. American journal of cancer research 23 22957307
2013 COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels. The Journal of biological chemistry 22 23926111
2008 RanBPM, a novel interaction partner of the brain-specific protein p42IP4/centaurin alpha-1. Journal of neurochemistry 22 18298663
2006 Human Dectin-1 isoform E is a cytoplasmic protein and interacts with RanBPM. Biochemical and biophysical research communications 22 16870151
2012 RanBPM is an inhibitor of ERK signaling. PloS one 21 23118896
2015 Characterization of RanBPM molecular determinants that control its subcellular localization. PloS one 19 25659156
2017 CLOCK interacts with RANBP9 and is involved in alternative splicing in spermatogenesis. Gene 18 29126923
2014 RanBP9 modulates AICD localization and transcriptional activity via direct interaction with Tip60. Journal of Alzheimer's disease : JAD 18 25024339
2004 Sperm membrane protein (hSMP-1) and RanBPM complex in the microtubule-organizing centre. Journal of molecular medicine (Berlin, Germany) 18 15014887
2009 Regulation of mu opioid receptor internalization by the scaffold protein RanBPM. Neuroscience letters 17 19788913
2017 Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex. BMC cancer 16 28668087
2018 RANBP9 affects cancer cells response to genotoxic stress and its overexpression is associated with worse response to platinum in NSCLC patients. Oncogene 15 30076413
2014 RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer's disease. Neurobiology of disease 14 24892886
2013 RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice. PloS one 14 23840553
2013 RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility. The Journal of biological chemistry 14 23928309
2009 A genetic test for yeast two-hybrid bait competency using RanBPM. Genetics 14 19487565
2009 RanBPM is an acetylcholinesterase-interacting protein that translocates into the nucleus during apoptosis. Acta biochimica et biophysica Sinica 14 19902122
2020 Lipopolysaccharide-Induced Acute Lung Injury Is Associated with Increased Ran-Binding Protein in Microtubule-Organizing Center (RanBPM) Molecule Expression and Mitochondria-Mediated Apoptosis Signaling Pathway in a Mouse Model. Medical science monitor : international medical journal of experimental and clinical research 13 32680981
2010 The Drosophila gene RanBPM functions in the mushroom body to regulate larval behavior. PloS one 13 20498842
2008 Modulation of Ca(v)3.1 T-type Ca2+ channels by the ran binding protein RanBPM. Biochemical and biophysical research communications 13 18801335
2016 Reduced RanBPM Expression Is Associated with Distant Metastasis in Gastric Cancer and Chemoresistance. Anticancer research 12 26977028
2014 RanBP9 overexpression reduces dendritic arbor and spine density. Neuroscience 12 24486966
2013 RanBPM interacts with TβRI, TRAF6 and curbs TGF induced nuclear accumulation of TβRI. Cellular signalling 12 24103590
2016 Structural Basis for the Interaction between the IUS-SPRY Domain of RanBPM and DDX-4 in Germ Cell Development. Journal of molecular biology 11 27622290
2014 RanBP9 overexpression down-regulates phospho-cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain. Journal of Alzheimer's disease : JAD 11 24254706
2011 The Ran-binding protein RanBPM can depress the NF-κB pathway by interacting with TRAF6. Molecular and cellular biochemistry 11 21805090
2016 RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells. Oncotarget 10 27835883
2015 RanBPM regulates Zta-mediated transcriptional activity in Epstein-Barr virus. The Journal of general virology 10 25900136
2017 RanBPM: a potential therapeutic target for modulating diverse physiological disorders. Drug discovery today 9 28847759
2014 RanBP9 overexpression accelerates loss of pre and postsynaptic proteins in the APΔE9 transgenic mouse brain. PloS one 9 24454876
2020 Cloning, expression and purification of the low-complexity region of RanBP9 protein. Protein expression and purification 8 32217127
2019 RANBP9 suppresses tumor proliferation in colorectal cancer. Oncology letters 8 30988811
2017 Reduced Expression of RanBPM Is Associated with Poorer Survival from Lung Cancer and Increased Proliferation and Invasion of Lung Cancer Cells In Vitro. Anticancer research 7 28739732
2016 Expression of cartilage antitumor component RanBP9 in osteosarcoma. Journal of biological regulators and homeostatic agents 7 27049080
2014 Investigating the potential genetic association between RANBP9 polymorphisms and the risk of schizophrenia. Molecular medicine reports 7 25482375
2018 Scaffolding protein RanBPM and its interactions in diverse signaling pathways in health and disease. Discovery medicine 6 29723489
2023 ATM-Mediated translocation of RanBPM regulates DNA damage response by stabilizing p21 in non-small cell lung cancer cells. Cellular oncology (Dordrecht, Netherlands) 5 37676377
2021 Downregulation of circ-RANBP9 in laryngeal cancer and its clinical significance. Annals of translational medicine 5 33850881
2020 RANBP9 as potential therapeutic target in non-small cell lung cancer. Journal of cancer metastasis and treatment 4 34778565
2017 Mind Bomb-Binding Partner RanBP9 Plays a Contributory Role in Retinal Development. Molecules and cells 4 28359144
2016 RanBPM inhibits BLT2-mediated IL-8 production and invasiveness in aggressive breast cancer cells. Biochemical and biophysical research communications 4 28027932
2025 An in vivo "turning model" reveals new RanBP9 interactions in lung macrophages. Cell death discovery 3 40223093
2017 Ran binding protein 9 (RanBPM) binds IFN-λR1 in the IFN-λ signaling pathway. Science China. Life sciences 3 28547582
2013 RanBPM, a scaffolding protein for gametogenesis. Current topics in developmental biology 3 23287040
2025 RANBP9 and RANBP10 cooperate in regulating non-small cell lung cancer proliferation. Journal of experimental & clinical cancer research : CR 2 40883813
2017 1H, 13C and 15N chemical shift assignment of lissencephaly-1 homology (LisH) domain homodimer of human two-hybrid-associated protein 1 with RanBPM (Twa1). Biomolecular NMR assignments 2 29067546
2007 [Multiadaptor 4.1 and RanBP9 protein family members as putative interaction partners for VARP, a Rab21 GTPase guanine nucleotide exchange factor]. Molekuliarnaia biologiia 1 18318119