Affinage

RANBP9

Ran-binding protein 9 · UniProt Q96S59

Length
729 aa
Mass
77.8 kDa
Annotated
2026-06-10
100 papers in source corpus 57 papers cited in narrative 57 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RANBP9 (RanBPM) is a nucleocytoplasmic scaffolding protein that assembles multiprotein complexes through its SPRY and LisH/CTLH domains to coordinate receptor signaling, the DNA damage response, protein turnover, and apoptosis (PMID:17467196, PMID:27622290, PMID:12147692). It is a core subunit of the large (>670 kDa) CTLH E3 ubiquitin ligase complex together with Muskelin, Twa1, p48EMLP, p44CTLH, ARMC8α/β, and MAEA, and this complex governs HDAC6-dependent α-tubulin deacetylation and cell migration (PMID:11470507, PMID:17467196, PMID:28668087); its paralog RANBP10 can substitute as the complex-organizing subunit, with the two acting as partial antagonists that tune ubiquitylation output and proliferation (PMID:40883813). Its β-sandwich SPRY domain presents a shallow conserved binding surface that engages diverse partners, including the tyrosine kinase domains of MET, Axl, TrkA, and c-Kit and the RNA helicase DDX4 (PMID:27622290, PMID:12147692, PMID:15964779, PMID:27835883); through these interactions RANBP9 acts as an adaptor that recruits Sos to activate Ras-ERK signaling at MET while modulating multiple other receptor and nuclear-receptor outputs (PMID:12147692, PMID:16595702). In the DNA damage response, RANBP9 is phosphorylated by ATM and translocates to the nucleus, where it promotes efficient ATM/Chk2/γH2AX activation and homologous recombination and stabilizes p21 by recruiting the deubiquitinase USP11 in a p53-independent manner (PMID:26943034, PMID:37676377); RANBP9 itself is a degradation substrate whose levels are set by USP11 deubiquitination and COPS5-mediated stabilization (PMID:12084015, PMID:23926111). RANBP9 drives mitochondrial apoptosis by activating cofilin via SSH1 and cooperating with p73, and it promotes amyloidogenic APP processing by scaffolding APP, BACE1, and LRP to accelerate their endocytosis, with these activities validated in transgenic and null mouse models of amyloid and tau pathology (PMID:22361682, PMID:23348590, PMID:19251705, PMID:25741591, PMID:29016855). In dendritic cells, RANBP9 bridges AXL and LRP-1 to mediate efferocytosis and antigen cross-presentation (PMID:24509082). RANBP9 is essential for mammalian gametogenesis, with null mice of both sexes sterile due to meiotic arrest and premature ovarian failure (PMID:21561988).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 1998 Medium

    Established the first molecular identity of RanBPM as a Ran-GTP-binding protein with a proposed role in microtubule nucleation, anchoring it to the centrosomal/cytoskeletal compartment.

    Evidence Yeast two-hybrid with Ran bait, fractionation, and antibody inhibition of aster formation

    PMID:9817760

    Open questions at the time
    • Based on a truncated isoform later shown not to be centrosomal
    • Catalytic mechanism of microtubule nucleation not defined
  2. 2001 High

    Corrected the protein model by showing the authentic full-length protein is 90 kDa, forms a >670 kDa complex, and localizes to nucleus and perinuclear cytoplasm rather than the centrosome itself.

    Evidence Full-length cDNA cloning, multi-epitope immunoblotting, gel filtration, and immunofluorescence

    PMID:11470507

    Open questions at the time
    • Identity of the >670 kDa complex partners not yet defined
    • Functional consequence of nuclear vs cytoplasmic pools unresolved
  3. 2002 High

    Defined RANBP9 as a SPRY-domain adaptor that couples the MET receptor to Ras-ERK signaling and as a regulator of nuclear receptors, establishing its role in receptor-driven transcription.

    Evidence Y2H, GST pull-down, Co-IP, Ras-GTP loading and ERK/SRE reporter assays for MET; reciprocal pull-down and reporter assays for AR/GR

    PMID:12147692 PMID:12361945

    Open questions at the time
    • Whether the same SPRY surface mediates both kinase and receptor binding not resolved
    • Endogenous physiological relevance of nuclear receptor coactivation beyond overexpression unclear
  4. 2002 High

    Showed RANBP9 is itself a proteasome substrate whose stability is set by USP11 deubiquitination, framing it as a tightly turned-over scaffold.

    Evidence Y2H, Co-IP, pulse-chase with proteasome inhibitors, and in vitro/in vivo ubiquitination with recombinant USP11

    PMID:12084015

    Open questions at the time
    • E3 ligase ubiquitinating RANBP9 not identified
    • Signals that regulate USP11 engagement unknown
  5. 2003 Medium

    Identified the core LisH-CTLH module shared by RanBPM, Twa1, and Muskelin, providing the first evidence of a defined RANBP9-containing protein assembly.

    Evidence Y2H, reciprocal Co-IP, and gel-filtration chromatography

    PMID:12559565

    Open questions at the time
    • Full composition and enzymatic activity of the assembly not yet defined
    • Stoichiometry and architecture unknown
  6. 2007 High

    Defined the full CTLH complex composition, establishing RANBP9 as a stable subunit of a large multiprotein assembly rather than a free adaptor.

    Evidence Anti-RanBPM IP-tandem MS from HEK293, Co-IP, and in vitro Twa1 pull-down across components

    PMID:17467196

    Open questions at the time
    • Catalytic/E3 activity of the complex not demonstrated at this stage
    • Substrate repertoire unknown
  7. 2009 High

    Linked RANBP9 to amyloidogenesis by showing its N-terminal SPRY-LisH module scaffolds APP, BACE1, and LRP to accelerate APP endocytosis and Abeta production.

    Evidence Co-IP, surface biotinylation, endocytosis and lipid-raft assays, siRNA knockdown, and Abeta ELISA in CHO cells and primary neurons

    PMID:19251705 PMID:19729516

    Open questions at the time
    • Whether CTLH complex E3 activity contributes to APP processing not addressed
    • Relationship of the stable N60 processed form to physiological signaling unclear
  8. 2009 Medium

    Established RANBP9 as a proapoptotic factor that relocalizes from nucleus to cytoplasm after DNA damage and is required for caspase activation and mitochondrial Bax/Bcl-2 balance.

    Evidence Transient expression, siRNA knockdown, caspase assays, relocalization immunofluorescence, and Bax/Bcl-2 western blot after irradiation

    PMID:19996306

    Open questions at the time
    • Mechanism of nucleocytoplasmic relocalization not defined here
    • How SPRY domain negatively regulates apoptosis unclear
  9. 2011 High

    Demonstrated an essential, cell-autonomous in vivo requirement for RANBP9 in gametogenesis, identifying meiotic prophase I as the critical stage.

    Evidence Mouse knockout with histology, meiotic staging, and chimera experiments using knockout ES cells

    PMID:21561988

    Open questions at the time
    • Molecular pathway through which RANBP9 supports meiotic progression not defined
    • Relevant germ-cell partners not identified
  10. 2012 High

    Connected RANBP9 to mitochondrial apoptosis and cytoskeletal regulation by placing cofilin downstream of RANBP9 and showing in vivo amyloid and synaptic phenotypes from RANBP9 dosage.

    Evidence siRNA epistasis for cofilin, cofilin phosphorylation blots, integrin endocytosis/focal-adhesion assays, and transgenic/null mouse Abeta and synaptic protein analyses

    PMID:22223749 PMID:22294787 PMID:22361682

    Open questions at the time
    • Direct enzyme linking RANBP9 to cofilin dephosphorylation not yet identified
    • Mechanism coupling integrin trafficking to apoptosis unresolved
  11. 2013 High

    Showed RANBP9 cooperates with p73 to execute mitochondria-mediated death and is itself stabilized by COPS5, integrating its apoptotic and turnover regulation.

    Evidence Co-IP, bidirectional siRNA epistasis, mitochondrial membrane potential, Bax oligomerization and cytochrome c release assays; COPS5 half-life and Abeta ELISA experiments

    PMID:23348590 PMID:23926111

    Open questions at the time
    • How RANBP9 increases p73 transcriptionally not mechanistically resolved
    • COPS5 mechanism of stabilization (CTLH-dependent or not) unclear
  12. 2014 High

    Defined RANBP9 as an HDAC6 regulator and an aggresome-forming factor, and established its CTLH/AXL-LRP-1 scaffolding role in dendritic-cell efferocytosis and cross-presentation in vivo.

    Evidence Co-IP with domain deletion, HDAC6 deacetylase assays, shRNA rescue of aggresome formation; in vivo DC-specific deletions, efferocytosis and cross-presentation assays, HSV-1 model

    PMID:24509082 PMID:24795145

    Open questions at the time
    • Whether HDAC6 inhibition requires intact CTLH E3 activity not fully resolved here
    • Direct vs indirect bridging of AXL-LRP-1 mechanistically incomplete
  13. 2015 High

    Mapped RANBP9 nucleocytoplasmic shuttling determinants and showed CTLH-complex-mediated HDAC6 inhibition restrains migration, plus the SSH1-cofilin axis underlying its neurotoxic activity in vivo.

    Evidence Systematic NLS/NES deletion analysis with fractionation; Co-IP of CTLH members with HDAC6 and migration assays; SSH1-dependent cofilin translocation and APP/PS1 mouse rescue with LTP and behavior

    PMID:25659156 PMID:25741591 PMID:28668087

    Open questions at the time
    • How DNA damage triggers the NES-dependent shift not defined
    • Whether SSH1 regulation is direct or via the CTLH complex unclear
  14. 2016 High

    Solved the SPRY domain structure to define its peptide-binding surface, and established RANBP9 as an ATM substrate that promotes the DNA damage response and supports c-Kit protein stability.

    Evidence X-ray crystallography of apo and DDX4-peptide complex with mutagenesis; ATM phospho-site mapping (S181/S603), nuclear accumulation with ATM inhibition, HR reporter; Co-IP and null-mouse c-Kit protein/mRNA analysis

    PMID:26943034 PMID:27622290 PMID:27835883

    Open questions at the time
    • How ATM phosphorylation drives nuclear accumulation mechanistically incomplete
    • Whether SPRY surface mediates all kinase interactions not generalized structurally
  15. 2023 Medium

    Defined the molecular basis of RANBP9's DDR function by showing it stabilizes p21 through USP11 recruitment in a p53-independent manner.

    Evidence Co-IP of RanBP9-p21-USP11, in vivo ubiquitylation assay, overexpression/silencing, and ATM-dependent nuclear translocation with DDR readouts

    PMID:37676377

    Open questions at the time
    • Whether p21 stabilization involves the CTLH complex not addressed
    • Single-lab finding without reciprocal in vivo validation
  16. 2025 Medium

    Revealed tissue- and tag-specific RANBP9 interactomes and paralog interplay, showing RANBP9 and RANBP10 independently nucleate the CTLH complex and antagonistically tune its ubiquitylation output.

    Evidence In vivo TurnX knock-in macrophage proteomics with tag-switching control; inducible NSCLC overexpression/loss-of-function with proteomics and ubiquitylome profiling and patient lysates

    PMID:40223093 PMID:40883813

    Open questions at the time
    • Substrates uniquely specified by RANBP9 vs RANBP10 not fully defined
    • Functional consequences of macrophage-specific interactions not validated

Open questions

Synthesis pass · forward-looking unresolved questions
  • The direct substrate repertoire of the RANBP9-containing CTLH E3 ligase and how RANBP9's scaffolding choices are selected across tissues and signaling states remain unresolved.
  • No defined catalytic ubiquitination substrate set attributable specifically to RANBP9
  • Rules governing partner selection among receptors, DDR factors, and apoptotic effectors unknown
  • Structural basis for assembly into the full CTLH complex not determined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0098772 molecular function regulator activity 3 GO:0140096 catalytic activity, acting on a protein 2
Localization
GO:0005634 nucleus 3 GO:0005829 cytosol 3 GO:0005856 cytoskeleton 2 GO:0000228 nuclear chromosome 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1643685 Disease 3 R-HSA-392499 Metabolism of proteins 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-73894 DNA Repair 2 R-HSA-1474165 Reproduction 1 R-HSA-168256 Immune System 1
Partners
AXLCDKN1ACOPS5HDAC6LRP1METMUSKELINUSP11
Complex memberships
CTLH complex

Evidence

Reading pass · 57 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 RanBPM (RanBP9) was identified as a centrosomal protein that binds GTP-Ran and is required for microtubule nucleation; overexpression produced ectopic microtubule nucleation sites co-localizing with gamma-tubulin, and anti-RanBPM antibodies inhibited microtubule aster formation. Yeast two-hybrid (Ran bait), sucrose-density gradient centrifugation, immunofluorescence, antibody inhibition assays The Journal of cell biology Medium 9817760
2001 The originally described 55 kDa RanBPM was a truncated isoform; the full-length protein is 90 kDa with an N-terminal proline/glutamine-rich region, forms a >670 kDa complex, and localizes predominantly to nucleus and cytoplasm surrounding the centrosome—not within the centrosome itself. Full-length cDNA cloning, immunoblotting with antibodies against three distinct regions, gel filtration, immunofluorescence Gene High 11470507
2002 RanBPM interacts with the tyrosine kinase domain of MET receptor via its SPRY domain; RanBPM activates the Ras-Erk-SRE pathway by recruiting Sos to the MET complex, functioning as an adaptor protein. Yeast two-hybrid, in vitro GST pull-down, co-immunoprecipitation, Ras-GTP loading assay, ERK phosphorylation assay, SRE-luciferase reporter, cell migration assay The Journal of biological chemistry High 12147692
2002 RanBPM interacts with androgen receptor (AR) and glucocorticoid receptor (GR), but not estrogen receptor, and enhances their transcriptional activity in a ligand-dependent manner when overexpressed in prostate cancer cells. Yeast two-hybrid, GST pull-down, His-tag pull-down, transient overexpression with luciferase reporter assays The Journal of biological chemistry Medium 12361945
2002 USP11, a ubiquitin-specific protease, interacts with RanBPM and deubiquitinates it; RanBPM undergoes proteasome-dependent degradation and is ubiquitinated in vivo and in vitro, and USP11 inhibits this ubiquitination in a dose-dependent manner. Yeast two-hybrid, co-immunoprecipitation, pulse-chase analysis with proteasome inhibitors, in vivo and in vitro ubiquitination assays, recombinant USP11 inhibition assay The Biochemical journal High 12084015
2002 HIPK2 (homeodomain-interacting protein kinase 2) interacts with RanBPM in the nucleus of mammalian cells; both wild-type HIPK2 and a kinase-dead HIPK2 mutant co-localize with RanBPM in defined nuclear structures. Yeast two-hybrid, co-immunoprecipitation in mammalian cells, immunofluorescence co-localization Biochemical and biophysical research communications Low 12220523
2003 RanBPM forms a protein complex with Twa1 and Muskelin (hMuskelin), as demonstrated by co-immunoprecipitation and gel-filtration analysis; all three proteins share the LisH-CTLH motif. Yeast two-hybrid, co-immunoprecipitation, gel-filtration chromatography Gene Medium 12559565
2003 RanBPM interacts with the death domain of p75NTR neurotrophin receptor intracellular domain. Yeast two-hybrid, co-immunoprecipitation in mammalian cells, domain mapping Biochemical and biophysical research communications Low 12963025
2003 CDK11(p46), a caspase-processed apoptotic kinase, directly interacts with RanBPM via its SPRY domain and phosphorylates RanBPM in vitro. Yeast two-hybrid, in vitro binding assay, co-immunoprecipitation in human cells, in vitro kinase assay Biochemical and biophysical research communications Medium 14511641
2004 RanBPM is a peripheral plasma membrane protein that interacts with the cytoplasmic domain of integrin LFA-1 (beta2) and beta1 integrin via in vitro and in vivo assays; RanBPM is phosphorylated on serine residues and this phosphorylation is regulated by p38 kinase activity; RanBPM synergizes with LFA-1 in AP-1-dependent transcriptional activation. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, membrane fractionation, phosphorylation assays with p38 inhibitor SB203580, luciferase reporter assay The Journal of biological chemistry High 14722085
2004 RanBPM interacts with the tyrosine kinase domain of Axl and Sky/Tyro3 receptor tyrosine kinases via its SPRY-LisH domain region; a truncated RanBPM lacking this region fails to interact with Axl; endogenous Axl and RanBPM interact constitutively in multiple mammalian cell lines. Yeast two-hybrid, co-immunoprecipitation in cell-free and mammalian cell systems, domain deletion analysis, Gas6 stimulation experiment The international journal of biochemistry & cell biology Medium 15964779
2004 Mouse RanBPM interacts with the germline-specific RNA helicase MVH (mouse vasa homolog) in testicular germ cells; both proteins associate with perinuclear RNA-protein complexes and chromatoid bodies. Yeast two-hybrid, co-localization by immunofluorescence in testis Molecular reproduction and development Low 14648869
2005 RanBPM interacts with p73alpha (but not p53) through the extreme C-terminal region of p73alpha; RanBPM stabilizes p73alpha by inhibiting its ubiquitination, thereby prolonging its half-life and enhancing its proapoptotic activity; co-expression causes nuclear co-localization of RanBPM and p73alpha. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, immunofluorescence, ubiquitination assay, half-life analysis Oncogene Medium 15558019
2005 RanBPM interacts with the cytoplasmic domain of neural cell adhesion molecule L1 via its N-terminal SPRY domain; overexpression of N-RanBPM reduces L1-triggered ERK1/2 activation by 50% and inhibits L1-mediated neurite outgrowth and branching. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, L1 antibody patching/subcellular redistribution, ERK activation assay, primary neuron morphology Journal of neurochemistry Medium 16000162
2005 RanBPM interacts with TAF4 (a TFIID subunit); co-transfection of TAF4 and RanBPM increases primary neurite processes in neural progenitors; the effect is abolished by a TAF4 isoform lacking the RanBPM-interacting domain. Protein-protein interaction screen, co-immunoprecipitation from neural stem cell extracts, co-transfection/morphology assay Molecular and cellular neurosciences Low 15911349
2006 RanBPM associates with the N-terminus of CD39/ecto-NTPDase1; co-expression of RanBPM substantially reduces NTPDase activity of recombinant CD39 but not of an N-terminus-deleted CD39 mutant, demonstrating functional regulation of ecto-nucleotidase activity. Yeast two-hybrid, co-immunoprecipitation in transfected mammalian cells, NTPDase activity assay, domain deletion mutant analysis The Biochemical journal Medium 16478441
2006 RanBPM physically interacts with Plexin-A1 and mediates Semaphorin3A signaling; overexpression of RanBPM with Plexin-A1 reduces cell spreading and inhibits axonal outgrowth in vitro and in vivo; a truncated RanBPM blocks Sema3A responsiveness; RanBPM knockdown reduces Sema3A responsiveness; the RanBPM/Plexin-A1 complex is regulated by MICAL expression. Domain-based interaction screen, co-immunoprecipitation, overexpression and truncation/knockdown functional assays in neurons and non-neuronal cells, in vivo axon guidance assay The Journal of neuroscience High 16672672
2006 RanBPM interacts with TrkA via its SPRY motif (binding at TrkA tyrosine kinase domain); overexpression of RanBPM inhibits NGF-induced NFAT-dependent luciferase expression. Yeast two-hybrid, co-immunoprecipitation, GST pull-down, NFAT-luciferase reporter assay Neuroscience letters Low 16959415
2006 RanBPM is a coactivator of thyroid hormone receptors (TRs); it binds TRs in a ligand-independent manner via its C-terminal region interacting with the TR DNA-binding domain; overexpression enhances TR-dependent transcriptional activation, whereas the truncated RanBPM55 lacking the N-terminal polyglutaminated region inhibits it in a dominant-negative manner. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, transient transfection luciferase reporter, domain deletion competition assays Journal of molecular endocrinology Medium 16595702
2007 RanBPM is a component of a large protein complex (renamed CTLH complex) composed of Muskelin, p48EMLP, p44CTLH, ARMC8alpha, and ARMC8beta; each component was confirmed by co-immunoprecipitation and in vitro Twa1 pull-down. Tandem MS with anti-RanBPM antibody immunoprecipitation from HEK293 cells, co-immunoprecipitation in Cos-7 cells, in vitro pull-down with bacterially expressed Twa1 Gene High 17467196
2008 Muskelin subcellular localization is co-regulated with RanBP9; knockdown of muskelin or RanBP9 both produce protrusive cell morphologies with enlarged cell perimeters; RanBP9 binding via the muskelin C-terminus is required to restore normal morphology, identifying a muskelin-RanBP9 complex as a nucleocytoplasmic mediator of cell morphology. Subcellular fractionation, siRNA knockdown, rescue with cDNA variants, cell morphology quantification The Journal of cell biology Medium 18710924
2008 RanBPM interacts with metabotropic glutamate receptors mGlu2 and other group II and group III receptors (except mGlu6) in the retina, co-localizing with mGlu8b in the inner plexiform layer. Yeast two-hybrid (mGlu8 bait), co-immunoprecipitation, immunofluorescence co-localization in retina sections FEBS letters Low 18555800
2008 RanBPM interacts with p42(IP4)/Centaurin-alpha-1 via its SPRY domain; D-Ins(1,3,4,5)P4 (a specific ligand for p42(IP4)) inhibits this interaction in a concentration-dependent and stereoselective manner. Co-immunoprecipitation with endogenous RanBPM from rat brain, in vitro binding assay, inositol phosphate competition assay, domain mapping with SPRY domain Journal of neurochemistry Medium 18298663
2008 RanBPM interacts with Rta (EBV immediate-early protein) via the SPRY domain of RanBPM; this interaction promotes Rta transactivation activity, and mechanistically RanBPM interacts with SUMO-E2 (Ubc9) to enhance sumoylation of Rta by SUMO-1. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, confocal co-localization, transient transfection reporter assay, sumoylation assay Journal of molecular biology Medium 18455188
2008 RanBPM modulates T-type Ca2+ channel Cav3.1 by binding its intracellular loop between transmembrane domains I and II; RanBPM expression increases Cav3.1 currents and abolishes PKC activator-mediated inhibition of these currents. Yeast two-hybrid, whole-cell patch-clamp electrophysiology, domain binding assay Biochemical and biophysical research communications Medium 18801335
2008 Drosophila RanBPM is required for normal germline stem cell (GSC) niche organization; loss of the long RanBPM isoform causes defects in niche cell size, niche organization, and abnormal accumulation of adherens junction component Armadillo (beta-catenin), increasing GSC attachment to niche cap cells. Drosophila genetics (null and isoform-specific alleles), mosaic analysis, immunofluorescence for Armadillo and Hts The Journal of cell biology Medium 18762575
2009 RanBPM promotes BACE1 cleavage of APP and Abeta generation; RanBP9 N-terminal SPRY-LisH domain interacts with LRP, APP, and BACE1 simultaneously, scaffolding these proteins together; RanBP9 reduces cell surface APP, accelerates APP internalization, and increases lipid raft association of APP; knockdown of endogenous RanBP9 significantly reduces Abeta generation in CHO cells and primary neurons. Co-immunoprecipitation, cell surface biotinylation, endocytosis assay, lipid raft fractionation, siRNA knockdown, Abeta ELISA The Journal of biological chemistry High 19251705
2009 A processed form of RanBP9 (RanBP9-N60, residues 1-392) lacks a nuclear localization signal, displays enhanced cytoplasmic localization and >3-fold enhanced stability compared to full-length RanBP9, retains capacity to form self-interacting multimeric complexes via LisH domain, and potentiates Abeta generation ~5-fold. Deletion mutant analysis, subcellular fractionation, protein stability assays, Abeta ELISA FASEB journal Medium 19729516
2009 RanBPM has proapoptotic activity: transient expression induces caspase activation; the C-terminal domain stimulates this activity while the central SPRY domain negatively regulates it; RanBPM knockdown prevents DNA damage-induced caspase-3 and caspase-2 activation; following ionizing radiation, RanBPM relocalizes from nucleus to cytoplasm; RanBP9 downregulation decreases mitochondria-associated Bax and increases Bcl-2. Transient expression, siRNA knockdown, caspase activation assay, immunofluorescence for relocalization, Bax/Bcl-2 western blot Molecular cancer research Medium 19996306
2009 RanBPM interacts with acetylcholinesterase (AChE) C-terminal domain and translocates from the cytoplasm to the nucleus during cisplatin-induced apoptosis, similar to AChE. Yeast two-hybrid, co-immunoprecipitation, immunoblotting of cytoplasmic and nuclear fractions Acta biochimica et biophysica Sinica Low 19902122
2010 RanBPM interacts with citron kinase (CITK) at adherens junctions of the neocortical ventricular surface; RanBPM knockdown decreases CITK polarization to the ventricular surface, increases mitotic cells, and decreases cytokinetic cells; the CITK mutation rescues the RanBPM knockdown mitosis phenotype, placing RanBPM upstream of CITK in M-phase progression. Yeast two-hybrid, co-immunoprecipitation, protein overlay, in utero RNAi, genetic epistasis with CITK mutant Developmental neurobiology Medium 19790105
2010 RanBPM interacts with TrkB receptor and contributes to BDNF-induced MAPK and Akt activation; RanBPM overexpression enhances BDNF-induced MAPK/Akt signaling; RanBPM siRNA knockdown has opposite effects; RanBPM promotes BDNF-induced hippocampal neuronal morphogenesis and BDNF-mediated survival. Co-immunoprecipitation, overexpression and siRNA knockdown, phospho-MAPK/Akt western blot, neuronal morphology and survival assays Journal of neurochemistry Medium 20403074
2010 RanBPM interacts with YPEL5 protein; RanBPM was identified as a YPEL5-binding protein and their interaction was confirmed by yeast two-hybrid. Yeast two-hybrid Genomics Low 20580816
2010 RanBPM interacts with Mgl-1 (mammalian Lgl1); RanBPM inhibits Mgl-1 proteasomal degradation and extends its half-life; RanBPM enhances Mgl-1 activity in cell migration and colony formation assays. Yeast two-hybrid, co-immunoprecipitation, GST pull-down, protein stability assay, cell migration and colony formation assays The Journal of biological chemistry Medium 20829363
2011 RanBPM is essential for mammalian gametogenesis: RanBPM-null mice of both sexes are sterile; males show spermatogenesis arrest at late pachytene-diplotene prophase I without chromosome synapsis defects; females show premature ovarian failure at prophase I; chimera experiments demonstrate cell-autonomous function in germ cells. Gene knockout in mice, histological analysis, meiotic staging, chimeric mouse generation with knockout ES cells Development High 21561988
2012 RanBP9 overexpression disrupts integrin-dependent cell attachment, spreading, and focal adhesion signaling (Pyk2/paxillin), while knockdown promotes these processes; RanBP9 accelerates endocytosis of β1-integrin, LRP, and APP; primary hippocampal neurons from RanBP9-transgenic mice show reduced surface β1-integrin, LRP, APP, and neurite arborization. Cell attachment/spreading assays, focal adhesion immunostaining, cell surface biotinylation, endocytosis assay, siRNA knockdown, primary neuron from transgenic mice FASEB journal High 22223749
2012 RanBP9 activates/dephosphorylates cofilin and promotes Abeta-induced apoptosis; siRNA knockdown of cofilin abolishes both Abeta- and RanBP9-induced apoptosis, placing cofilin downstream of RanBP9 in the apoptotic pathway. siRNA knockdown (cofilin, RanBP9), cofilin phosphorylation western blot, apoptosis assays (RanBP9-Tg mice), spatial memory testing Cell death and differentiation Medium 22361682
2012 RanBP9 overexpression in mice leads to >2-fold increase in Abeta40 and Abeta42 levels and increased amyloid plaque deposition; RanBP9-null mice show increased synaptic protein levels (synaptophysin, PSD-95, drebrin A). Transgenic and null mouse generation, ELISA for Abeta, amyloid plaque immunostaining, synaptic protein western blot FASEB journal High 22294787
2012 RanBPM inhibits ERK signaling by forming a complex with c-Raf, decreasing Hsp90 binding to c-Raf, and destabilizing c-Raf protein; RanBPM knockdown stimulates MEK and ERK phosphorylation leading to Bcl-2 upregulation; RanBPM expression prevents MEK/ERK activation by active RasV12 and active c-Raf. Co-immunoprecipitation (RanBPM-c-Raf complex), Hsp90 binding assay, siRNA/shRNA knockdown, ERK phosphorylation assay, Bcl-2 western blot, cell proliferation and migration assays PloS one Medium 23118896
2013 RanBP9 physically interacts with tumor suppressor p73, increases endogenous p73alpha levels at both transcriptional and post-translational levels, and cooperates with p73 to induce mitochondria-mediated cell death (loss of mitochondrial membrane potential, Bax oligomerization, cytochrome c release); RanBP9 knockdown suppresses p73-induced apoptosis and vice versa. Co-immunoprecipitation, p73 western blot (transcriptional and stability analysis), siRNA knockdown of p73 and RanBP9, mitochondrial membrane potential assay, Bax oligomerization, cytochrome c release, Mdivi-1/Bcl-2/Bcl-xl inhibitor experiments Cell death & disease High 23348590
2013 RanBP9 potentiates Abeta-induced ROS overproduction, apoptosis, and calcium deregulation in hippocampal neurons; RanBP9 selectively delays cytosolic Ca2+ clearance by the mitochondrial calcium uniporter through cofilin translocation to mitochondria; RanBP9 retards anterograde axonal transport of mitochondria and decreases synaptic mitochondrial activity. Primary hippocampal neuron overexpression, ROS assay, Ca2+ imaging, mitochondrial calcium uniporter blockade, cofilin mitochondrial translocation assay, axonal transport live imaging FASEB journal Medium 23982146
2013 COPS5 (Jab1/CSN5) is a novel RanBP9-interacting protein that stabilizes RanBP9 protein levels, thereby increasing Abeta generation; COPS5 increases RanBP9 half-life; COPS5 knockdown reduces Abeta generation. Yeast two-hybrid (human brain library), co-immunoprecipitation in neuronal and non-neuronal cells and mouse brain, protein half-life assay, siRNA knockdown, Abeta ELISA The Journal of biological chemistry Medium 23926111
2013 RanBPM interacts with TRAF6 via its SPRY motif; RanBPM inhibits TRAF6 ubiquitination and suppresses TRAF6-triggered NF-κB signaling; RanBPM also blocks TGF-β-induced TβRI nuclear accumulation by competing with TRAF6 for TβRI binding. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, confocal microscopy, FRET, ubiquitination assay, NF-κB reporter assay Cellular signalling Medium 24103590
2014 RanBPM promotes aggresome formation: ionizing radiation and proteasome inhibition cause RanBPM redistribution into perinuclear aggresomes with ubiquitin, dynein, and HDAC6; aggresome formation by HDAC6 is markedly impaired in RanBPM shRNA cells but restored by RanBPM re-expression; RanBPM interacts with HDAC6 via its LisH/CTLH domain and inhibits HDAC6 deacetylase activity. Immunofluorescence for aggresome markers, shRNA knockdown with rescue, co-immunoprecipitation (RanBPM-HDAC6), deacetylase activity assay, LisH/CTLH deletion mutant analysis Biology open High 24795145
2014 AXL, LRP-1, and RANBP9 form a multiprotein complex mediating DC efferocytosis; AXL binds apoptotic cells but requires LRP-1 for internalization; RANBP9 bridges AXL and LRP-1 (which do not interact directly) to form the complex; this complex is required for DC antigen cross-presentation to CD8+ T cells; mice lacking DC-specific LRP-1, AXL, or RANBP9 show increased AC accumulation and defective viral antigen-specific T cell responses. Targeted genetic deletion in mice, spleen efferocytosis assay, co-immunoprecipitation (AXL-RANBP9-LRP1), DC-T cell coculture cross-presentation assay, HSV-1 infection model The Journal of clinical investigation High 24509082
2014 RanBP9 physically interacts with tau and Hsp90/Hsc70 chaperone complexes; RanBP9 overexpression or knockdown directly increases or reduces tau levels in vitro and in vivo; RanBP9 enhances Hsp90 and Hsc70 ATPase activities; genetic reduction of RanBP9 ameliorates tauopathy in Tau-P301S mice. Co-immunoprecipitation (RanBP9-tau-Hsp90/Hsc70), in vitro ATPase assay, RanBP9 overexpression/knockdown western blot, Tau-P301S mouse model genetic reduction Human molecular genetics High 29016855
2015 RanBP9 interacts with HDAC6 and, together with the CTLH complex (via Twa1 and MAEA), inhibits HDAC6 deacetylase activity toward alpha-tubulin; RanBPM associates with microtubules in an HDAC6-dependent manner; RanBPM knockdown-induced increase in cell migration is due to relief of HDAC6 inhibition. Co-immunoprecipitation of HDAC6 with CTLH complex members, acetylated alpha-tubulin western blot, confocal microscopy, shRNA knockdown of multiple CTLH members, wound-healing migration assay BMC cancer Medium 28668087
2015 RanBPM contains two distinct nuclear localization motifs (N-terminal proline/glutamine-rich region dominant; C-terminal contributes minimally), one nuclear export signal (NES) whose mutation prevents cytoplasmic accumulation, and its cytoplasmic localization is also conferred by protein-protein interactions; in the cytoplasm, RanBPM partially co-localizes with and associates with alpha-tubulin; in the nucleus, RanBPM is associated with chromatin. Systematic deletion mutant analysis in RanBPM shRNA background, confocal microscopy, microtubule co-localization, chromatin fractionation PloS one Medium 25659156
2015 Endogenous RanBP9 mediates Abeta-induced cofilin translocation to mitochondria via Slingshot homolog 1 (SSH1); RanBP9 positively regulates SSH1 levels; RanBP9 reduction in APP/PS1 mice protects against cofilin-actin pathology, synaptic damage, gliosis, and Abeta accumulation; RanBP9 reduction significantly enhances LTP and partially rescues contextual memory deficits. siRNA knockdown, primary neuron cofilin translocation assay, in vivo APP/PS1 mouse RanBP9 reduction, LTP electrophysiology, behavioral memory testing Cell death & disease High 25741591
2016 Ran Binding Protein 9 (RanBP9) is phosphorylated by active ATM on at least S181 and S603 in response to ionizing radiation; DNA damage promotes RanBP9 nuclear accumulation in an ATM-dependent manner; RanBP9 silencing causes delayed activation of ATM, Chk2, γH2AX, and p53, and reduces homologous recombination efficiency, leading to enhanced IR-induced senescence and apoptosis. ATM phosphorylation site identification (S181/S603), ATM inhibition experiments, nuclear accumulation assay, RanBP9 stable silencing in multiple cell lines, ATM/Chk2/γH2AX western blot, homologous recombination reporter assay Oncotarget High 26943034
2016 RanBPM/RanBP9 scaffold protein binds c-Kit receptor tyrosine kinase and is required for normal c-Kit protein expression in mouse testis and hematopoietic lineages; RanBPM deletion reduces c-Kit protein but not mRNA, indicating post-translational regulation; this regulation is specific to c-Kit among membrane proteins examined. Co-immunoprecipitation (RanBPM-c-Kit), western blot (protein vs mRNA comparison), RanBPM-null mice phenotypic analysis, human cell line endogenous expression analysis Oncotarget Medium 27835883
2016 Crystal structure of the IUS-SPRY domain of RanBPM was determined; this domain adopts a beta-sandwich fold with a unique shallow binding surface formed by conserved loops, positive patch, and a tryptophan-lined bottom; a 20-mer peptide of DDX-4 (RNA helicase) binds this surface with KD ~13 µM; mutagenesis studies elucidate the interaction interface. X-ray crystallography of SPRY domain, crystal structure of peptide-domain complex, isothermal titration calorimetry or equivalent binding assay (KD determination), site-directed mutagenesis Journal of molecular biology High 27622290
2016 RanBP9 SPRY domain interacts with TSSC3 PH domain; RanBP9/TSSC3 complex forms a ternary complex with Src, scaffolding their interaction; this suppresses Src and Src-dependent Akt pathway activation, facilitating mitochondrial-associated anoikis and suppressing lung metastasis in vivo. Co-immunoprecipitation (RanBP9-TSSC3-Src), domain mapping, anoikis assay, Src/Akt phosphorylation western blot, in vivo lung metastasis model Cell death & disease Medium 28032865
2017 CLOCK interacts with RANBP9 (confirmed by yeast two-hybrid and co-immunoprecipitation in mouse testis); RANBP9 previously known to interact with SF3B3 (spliceosome component); CLOCK also interacts with SF3B3; CLOCK binds mRNAs involved in spermatogenesis (demonstrated by RIP-Seq), suggesting CLOCK-RANBP9 involvement in alternative splicing. Yeast two-hybrid, co-immunoprecipitation in mouse testis, RIP-Seq Gene Low 29126923
2023 RanBP9 physically interacts with p21 and recruits the deubiquitinase USP11 to maintain p21 protein stability by deubiquitination; RanBP9 silencing decreases p21 protein levels whereas overexpression increases p21 independent of p53 status; DNA damage promotes nuclear translocation of RanBP9 via ATM signaling; RanBP9 regulates DDR in a p21-dependent manner. Co-immunoprecipitation (RanBP9-p21-USP11), in vivo ubiquitylation assay, RanBP9 overexpression/silencing, nuclear translocation assay with ATM inhibition, DDR functional assays Cellular oncology Medium 37676377
2025 In lung macrophages, RanBP9-V5 co-immunoprecipitates known CTLH complex members; however, >90% of the lung RanBP9-associated proteome differs between the two tagged versions (V5 vs HA), revealing macrophage-specific interactions with proteins involved in innate immune response, DNA damage response, metabolism, and mitochondrial function. In vivo knock-in mouse model (RanBP9-TurnX with LysM-Cre), tandem affinity immunoprecipitation with mass spectrometry from lung tissue Cell death discovery Medium 40223093
2025 RANBP9 and RANBP10 can each independently support CTLH complex formation; acute overexpression of either Scorpin reshapes the NSCLC cell proteome and ubiquitylome; higher RANBP9/RANBP10 ratio is associated with greater cell proliferation; they act as partial antagonists modulating the CTLH complex ubiquitylation output. Inducible overexpression/loss-of-function cell lines, proteomics, ubiquitylome profiling, patient tumor lysate analysis Journal of experimental & clinical cancer research Medium 40883813

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin. The Journal of cell biology 165 9817760
2002 Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. The Journal of biological chemistry 127 12147692
2007 RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex. Gene 106 17467196
2014 An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. The Journal of clinical investigation 101 24509082
2001 Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex. Gene 97 11470507
2004 RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1. The Journal of biological chemistry 83 14722085
2002 RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor. The Journal of biological chemistry 83 12361945
2009 Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation. The Journal of biological chemistry 77 19251705
2002 Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. The Biochemical journal 77 12084015
2005 RanBPM is an L1-interacting protein that regulates L1-mediated mitogen-activated protein kinase activation. Journal of neurochemistry 76 16000162
2007 RanBPM, a scaffolding protein in the immune and nervous systems. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 71 18040864
2006 RanBPM contributes to Semaphorin3A signaling through plexin-A receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 69 16672672
2013 Molecular phylogeny of a RING E3 ubiquitin ligase, conserved in eukaryotic cells and dominated by homologous components, the muskelin/RanBPM/CTLH complex. PloS one 67 24143168
2012 Pivotal role of the RanBP9-cofilin pathway in Aβ-induced apoptosis and neurodegeneration. Cell death and differentiation 67 22361682
2015 RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction. Cell death & disease 65 25741591
2005 Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells. Oncogene 63 15558019
2003 A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM. Gene 62 12559565
2013 Cooperative role of RanBP9 and P73 in mitochondria-mediated apoptosis. Cell death & disease 59 23348590
2010 YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10. Genomics 58 20580816
2009 A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 56 19729516
2008 Novel role of the muskelin-RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation. The Journal of cell biology 56 18710924
2006 RanBPM associates with CD39 and modulates ecto-nucleotidase activity. The Biochemical journal 55 16478441
2002 RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer. BMC cancer 54 12421467
2005 A specific role for the TFIID subunit TAF4 and RanBPM in neural progenitor differentiation. Molecular and cellular neurosciences 46 15911349
2012 Pivotal role of RanBP9 in integrin-dependent focal adhesion signaling and assembly. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 45 22223749
2009 RanBPM has proapoptotic activities that regulate cell death pathways in response to DNA damage. Molecular cancer research : MCR 43 19996306
2008 Enhancement of transactivation activity of Rta of Epstein-Barr virus by RanBPM. Journal of molecular biology 40 18455188
2011 RanBPM is essential for mouse spermatogenesis and oogenesis. Development (Cambridge, England) 39 21561988
2005 The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases. The international journal of biochemistry & cell biology 39 15964779
2004 A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. Biochemical and biophysical research communications 38 14684163
2003 RanBPM is a novel binding protein for p75NTR. Biochemical and biophysical research communications 38 12963025
2014 A lentiviral sponge for miR-101 regulates RanBP9 expression and amyloid precursor protein metabolism in hippocampal neurons. Frontiers in cellular neuroscience 37 24592211
2011 Diverse roles of the scaffolding protein RanBPM. Drug discovery today 35 22094242
2017 Cell signalling pathway regulation by RanBPM: molecular insights and disease implications. Open biology 34 28659384
2004 Mouse RanBPM is a partner gene to a germline specific RNA helicase, mouse vasa homolog protein. Molecular reproduction and development 33 14648869
2002 HIPK2 associates with RanBPM. Biochemical and biophysical research communications 33 12220523
2010 Stability and function of mammalian lethal giant larvae-1 oncoprotein are regulated by the scaffolding protein RanBPM. The Journal of biological chemistry 32 20829363
2003 The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM. Biochemical and biophysical research communications 32 14511641
2013 Mitochondrial dysfunction and calcium deregulation by the RanBP9-cofilin pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31 23982146
2012 Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 30 22294787
2010 RanBPM regulates the progression of neuronal precursors through M-phase at the surface of the neocortical ventricular zone. Developmental neurobiology 30 19790105
2017 Enhanced tau pathology via RanBP9 and Hsp90/Hsc70 chaperone complexes. Human molecular genetics 29 29016855
2016 RanBP9/TSSC3 complex cooperates to suppress anoikis resistance and metastasis via inhibiting Src-mediated Akt signaling in osteosarcoma. Cell death & disease 29 28032865
2006 Identification and characterization of RanBPM, a novel coactivator of thyroid hormone receptors. Journal of molecular endocrinology 29 16595702
2006 The Ran binding protein RanBPM interacts with TrkA receptor. Neuroscience letters 29 16959415
2014 Aggresome formation is regulated by RanBPM through an interaction with HDAC6. Biology open 28 24795145
2008 RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors. FEBS letters 27 18555800
2008 RanBPM regulates cell shape, arrangement, and capacity of the female germline stem cell niche in Drosophila melanogaster. The Journal of cell biology 27 18762575
2010 RanBPM contributes to TrkB signaling and regulates brain-derived neurotrophic factor-induced neuronal morphogenesis and survival. Journal of neurochemistry 26 20403074
2016 Ran Binding Protein 9 (RanBP9) is a novel mediator of cellular DNA damage response in lung cancer cells. Oncotarget 25 26943034
2013 RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes. Cell death & disease 25 23764848
2013 COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels. The Journal of biological chemistry 24 23926111
2021 Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/XIAP axis. Bioengineered 23 34546853
2012 RanBPM expression regulates transcriptional pathways involved in development and tumorigenesis. American journal of cancer research 23 22957307
2008 RanBPM, a novel interaction partner of the brain-specific protein p42IP4/centaurin alpha-1. Journal of neurochemistry 22 18298663
2006 Human Dectin-1 isoform E is a cytoplasmic protein and interacts with RanBPM. Biochemical and biophysical research communications 22 16870151
2012 RanBPM is an inhibitor of ERK signaling. PloS one 21 23118896
2015 Characterization of RanBPM molecular determinants that control its subcellular localization. PloS one 19 25659156
2017 CLOCK interacts with RANBP9 and is involved in alternative splicing in spermatogenesis. Gene 18 29126923
2014 RanBP9 modulates AICD localization and transcriptional activity via direct interaction with Tip60. Journal of Alzheimer's disease : JAD 18 25024339
2004 Sperm membrane protein (hSMP-1) and RanBPM complex in the microtubule-organizing centre. Journal of molecular medicine (Berlin, Germany) 18 15014887
2009 Regulation of mu opioid receptor internalization by the scaffold protein RanBPM. Neuroscience letters 17 19788913
2017 Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex. BMC cancer 16 28668087
2018 RANBP9 affects cancer cells response to genotoxic stress and its overexpression is associated with worse response to platinum in NSCLC patients. Oncogene 15 30076413
2020 Lipopolysaccharide-Induced Acute Lung Injury Is Associated with Increased Ran-Binding Protein in Microtubule-Organizing Center (RanBPM) Molecule Expression and Mitochondria-Mediated Apoptosis Signaling Pathway in a Mouse Model. Medical science monitor : international medical journal of experimental and clinical research 14 32680981
2014 RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer's disease. Neurobiology of disease 14 24892886
2013 RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice. PloS one 14 23840553
2013 RanBPM protein acts as a negative regulator of BLT2 receptor to attenuate BLT2-mediated cell motility. The Journal of biological chemistry 14 23928309
2009 A genetic test for yeast two-hybrid bait competency using RanBPM. Genetics 14 19487565
2009 RanBPM is an acetylcholinesterase-interacting protein that translocates into the nucleus during apoptosis. Acta biochimica et biophysica Sinica 14 19902122
2010 The Drosophila gene RanBPM functions in the mushroom body to regulate larval behavior. PloS one 13 20498842
2008 Modulation of Ca(v)3.1 T-type Ca2+ channels by the ran binding protein RanBPM. Biochemical and biophysical research communications 13 18801335
2016 Reduced RanBPM Expression Is Associated with Distant Metastasis in Gastric Cancer and Chemoresistance. Anticancer research 12 26977028
2014 RanBP9 overexpression reduces dendritic arbor and spine density. Neuroscience 12 24486966
2013 RanBPM interacts with TβRI, TRAF6 and curbs TGF induced nuclear accumulation of TβRI. Cellular signalling 12 24103590
2016 Structural Basis for the Interaction between the IUS-SPRY Domain of RanBPM and DDX-4 in Germ Cell Development. Journal of molecular biology 11 27622290
2014 RanBP9 overexpression down-regulates phospho-cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain. Journal of Alzheimer's disease : JAD 11 24254706
2011 The Ran-binding protein RanBPM can depress the NF-κB pathway by interacting with TRAF6. Molecular and cellular biochemistry 11 21805090
2016 RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells. Oncotarget 10 27835883
2015 RanBPM regulates Zta-mediated transcriptional activity in Epstein-Barr virus. The Journal of general virology 10 25900136
2017 RanBPM: a potential therapeutic target for modulating diverse physiological disorders. Drug discovery today 9 28847759
2014 RanBP9 overexpression accelerates loss of pre and postsynaptic proteins in the APΔE9 transgenic mouse brain. PloS one 9 24454876
2020 Cloning, expression and purification of the low-complexity region of RanBP9 protein. Protein expression and purification 8 32217127
2019 RANBP9 suppresses tumor proliferation in colorectal cancer. Oncology letters 8 30988811
2017 Reduced Expression of RanBPM Is Associated with Poorer Survival from Lung Cancer and Increased Proliferation and Invasion of Lung Cancer Cells In Vitro. Anticancer research 7 28739732
2016 Expression of cartilage antitumor component RanBP9 in osteosarcoma. Journal of biological regulators and homeostatic agents 7 27049080
2014 Investigating the potential genetic association between RANBP9 polymorphisms and the risk of schizophrenia. Molecular medicine reports 7 25482375
2023 ATM-Mediated translocation of RanBPM regulates DNA damage response by stabilizing p21 in non-small cell lung cancer cells. Cellular oncology (Dordrecht, Netherlands) 6 37676377
2018 Scaffolding protein RanBPM and its interactions in diverse signaling pathways in health and disease. Discovery medicine 6 29723489
2021 Downregulation of circ-RANBP9 in laryngeal cancer and its clinical significance. Annals of translational medicine 5 33850881
2020 RANBP9 as potential therapeutic target in non-small cell lung cancer. Journal of cancer metastasis and treatment 4 34778565
2017 Mind Bomb-Binding Partner RanBP9 Plays a Contributory Role in Retinal Development. Molecules and cells 4 28359144
2016 RanBPM inhibits BLT2-mediated IL-8 production and invasiveness in aggressive breast cancer cells. Biochemical and biophysical research communications 4 28027932
2025 An in vivo "turning model" reveals new RanBP9 interactions in lung macrophages. Cell death discovery 3 40223093
2017 Ran binding protein 9 (RanBPM) binds IFN-λR1 in the IFN-λ signaling pathway. Science China. Life sciences 3 28547582
2013 RanBPM, a scaffolding protein for gametogenesis. Current topics in developmental biology 3 23287040
2025 RANBP9 and RANBP10 cooperate in regulating non-small cell lung cancer proliferation. Journal of experimental & clinical cancer research : CR 2 40883813
2017 1H, 13C and 15N chemical shift assignment of lissencephaly-1 homology (LisH) domain homodimer of human two-hybrid-associated protein 1 with RanBPM (Twa1). Biomolecular NMR assignments 2 29067546
2007 [Multiadaptor 4.1 and RanBP9 protein family members as putative interaction partners for VARP, a Rab21 GTPase guanine nucleotide exchange factor]. Molekuliarnaia biologiia 1 18318119
2024 An in vivo "turning model" reveals new RanBP9 interactions in lung macrophages. bioRxiv : the preprint server for biology 0 38826292

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