Affinage

RAB27B

Ras-related protein Rab-27B · UniProt O00194

Length
218 aa
Mass
24.6 kDa
Annotated
2026-04-28
85 papers in source corpus 45 papers cited in narrative 46 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB27B is a small GTPase that functions as a master regulator of regulated exocytosis, controlling the docking, maturation, and fusion of secretory granules, lysosome-related organelles, and multivesicular endosomes with the plasma membrane across a remarkably broad range of cell types including platelets, mast cells, neutrophils, exocrine acinar cells, parietal cells, neurons, melanocytes, and urothelial cells (PMID:17384153, PMID:19966785, PMID:15039459, PMID:20888820, PMID:29167152). RAB27B cycles between GTP-bound active and GDP-bound inactive states regulated by the GAP EPI64B and the GEF MADD, and recruits effector proteins including Slac2-b/EXPH5, Slac2-c/MyRIP, Slp1, Slp3, and Munc13-4 that couple vesicles to actin- and microtubule-based motors for polarized transport to the exocytic site (PMID:23671284, PMID:37604243, PMID:15039459, PMID:27810912, PMID:23281710). Beyond canonical secretion, RAB27B controls NRAS palmitoylation and plasma membrane trafficking through interaction with the palmitoyl acyltransferase ZDHHC9, thereby regulating RAS-ERK signaling in hematopoietic cells, and promotes lysosomal enzyme maturation and autophagic clearance of alpha-synuclein in neurons, with its loss exacerbating synucleinopathy and dopaminergic neurodegeneration in vivo (PMID:37317963, PMID:39965930, PMID:32350025). RAB27B transcription is regulated in a cell-type-specific manner by NF-E2 in megakaryocytes, FOXO1 in kidney tubular cells, NRF2 in urothelium, β-catenin/Tcf-4 in colorectal cells, SMAD3 in breast cancer, and CREB downstream of ZIP4 in pancreatic cancer (PMID:12907454, PMID:33597203, PMID:34686330, PMID:30980673, PMID:39723610, PMID:30342032).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2002 High

    Initial evidence placed RAB27B on secretory organelles and implicated its GTPase cycle in regulated secretion, establishing it as a functional paralog of RAB27A in endocrine cells and melanocytes.

    Evidence Dominant-negative Rab27b mutants inhibited ACTH secretion in pituitary AtT20 cells and redistributed melanosomes to the perinuclear region in melanocytes; Co-IP showed association with the effector granuphilin

    PMID:11956164 PMID:12060386

    Open questions at the time
    • No loss-of-function genetic model yet
    • Effector repertoire largely unknown
    • Mechanism of membrane association unclear
  2. 2003 High

    RAB27B was shown to localize to multiple granule types in megakaryocytes and fusiform vesicles in urothelium, and its transcription was found to be NF-E2-dependent, revealing tissue-specific transcriptional control of the regulated secretory machinery.

    Evidence ChIP demonstrated NF-E2 occupancy at the Rab27b promoter in megakaryocytes; dominant-negative Rab27 impaired proplatelet formation; immuno-EM placed Rab27b on fusiform vesicles in bladder urothelium

    PMID:12907454 PMID:14625374

    Open questions at the time
    • No Rab27b knockout mouse yet to confirm megakaryocyte phenotype in vivo
    • Functional role in urothelium inferred from localization, not direct loss-of-function
  3. 2004 High

    The identification of Slac2-c/MyRIP as a direct RAB27B effector on exocrine secretory granules established the paradigm of RAB27B recruiting linker proteins to couple granules to cytoskeletal motors for regulated exocytosis.

    Evidence Co-IP and immunohistochemistry in parotid acinar cells; functional blocking with recombinant SHD domain and antibodies inhibited amylase release; Rab27b GTP/GDP cycling mutants modulated pancreatic amylase secretion

    PMID:15039459 PMID:15451418

    Open questions at the time
    • Identity of actin/microtubule motors downstream of Slac2-c not yet defined
    • Relative contributions of effectors in exocrine cells unknown
  4. 2007 High

    Genetic knockout studies in mice established RAB27B as essential for platelet dense granule biogenesis, mast cell degranulation, and polarized delivery of secretory granules to the plasma membrane in pituitary cells, confirming non-redundancy with RAB27A.

    Evidence Rab27b KO mice showed hemorrhagic disease, reduced dense granules, and impaired platelet aggregation; double KO pituitary cells lost polarized granule distribution; Rab27b KO mast cells showed impaired degranulation and increased microtubule-based granule movement

    PMID:17384153 PMID:17587407 PMID:17761531

    Open questions at the time
    • Effector identity mediating platelet-specific vs. mast cell-specific functions not yet resolved
    • How Rab27b regulates granule number (biogenesis) vs. docking not mechanistically separated
  5. 2007 High

    The crystal structure of Rab27b-GDP revealed an unusually open switch region conformation with high flexibility, providing a structural basis for understanding its distinct effector recognition properties.

    Evidence X-ray crystallography in three crystal forms plus SAXS solution measurements of mouse Rab27b-GDP

    PMID:17582168

    Open questions at the time
    • No structure of GTP-bound form
    • No co-crystal with any effector
    • Structural basis of Rab27a vs. Rab27b effector selectivity unresolved
  6. 2009 High

    RAB27B was shown to control multivesicular endosome docking at the plasma membrane for exosome secretion, expanding its role beyond classical secretory granule exocytosis to the exosome biogenesis pathway.

    Evidence RNAi screen in HeLa cells; Rab27b silencing redistributed MVEs to perinuclear region and reduced exosome secretion; effector Slac2-b phenocopied the knockdown

    PMID:19966785

    Open questions at the time
    • MVE docking mechanism and fusion machinery downstream of Rab27b unknown
    • Whether Rab27b selects specific MVE cargo for exosomal release unclear
  7. 2010 High

    RAB27B was identified as an abundant synaptic vesicle protein that, unlike Rab3a, remains membrane-associated after exocytosis and resists GDI extraction, revealing a distinct recycling mechanism at presynaptic terminals.

    Evidence Quantitative iTRAQ proteomics and immunoblotting of purified synaptic vesicles; GDI extraction assay; manipulation of GTP/GDP switch impaired SV recycling

    PMID:20926670

    Open questions at the time
    • Functional redundancy with Rab3a at the synapse not yet genetically dissected
    • Effectors mediating Rab27b function at the synapse not identified
  8. 2010 High

    RAB27B was found to promote breast cancer invasion by delivering HSP90α-containing vesicles whose secretion activates extracellular MMP-2, linking its vesicle trafficking function to tumor progression.

    Evidence GFP-RAB27B vesicle proteomics identified HSP90α cargo; siRNA, GTP-binding and geranylgeranylation mutants reduced invasion; orthotopic xenograft confirmed in vivo relevance

    PMID:20484105

    Open questions at the time
    • How RAB27B vesicle cargo is selected unknown
    • Whether V-ATPase role is direct or indirect unclear
  9. 2013 High

    Genetic epistasis in mast cells resolved the division of labor between RAB27A and RAB27B: RAB27A/melanophilin/MyoVa controls cortical actin remodeling, while RAB27B/Munc13-4 directly mediates granule exocytosis, and EPI64B was identified as a RAB27B-specific GAP.

    Evidence Epistasis across ashen, Rab27b KO, double KO, leaden, dilute, and jinx mouse mast cells; EPI64B GAP activity shown by GTP-Rab27b pulldown with catalytic-dead mutagenesis in pancreatic acini

    PMID:23281710 PMID:23671284

    Open questions at the time
    • Whether EPI64B is the sole GAP for Rab27b unknown
    • How Munc13-4 couples to SNARE-mediated fusion not resolved
  10. 2016 High

    The Kif5b/Slp3/Rab27b complex was defined as the PI3K-dependent machinery linking secretory granules to kinesin-1 for microtubule-based transport to the exocytic site, explaining how Rab27b coordinates the switch from microtubule to actin-based motility.

    Evidence Kif5b conditional KO mice; Co-IP of kinesin-1/Slp3/Rab27b; PI3K inhibitor disrupted complex assembly; passive systemic anaphylaxis and BMMC degranulation assays

    PMID:27810912

    Open questions at the time
    • How PI3K signal triggers kinesin-1 recruitment to Slp3 mechanistically unclear
    • Whether this complex operates in cell types beyond mast cells untested
  11. 2020 Medium

    RAB27B was discovered to regulate autophagic clearance and lysosomal function in neurons, with its loss causing accumulation of insoluble alpha-synuclein and increased paracrine toxicity, and to be essential for hippocampal long-term potentiation.

    Evidence shRNA KD in neuronal α-syn model showed impaired LC3 turnover and increased insoluble α-syn; Rab27b KO mice completely lost MF-CA3 LTP, rescued by lentiviral human Rab27b re-expression

    PMID:32350025 PMID:32358861

    Open questions at the time
    • Mechanistic link between Rab27b and autophagosome-lysosome fusion not established
    • Effector mediating LTP function unknown
    • Single-lab findings for each
  12. 2023 High

    RAB27B was shown to control NRAS palmitoylation and plasma membrane trafficking by interacting with the palmitoyl acyltransferase ZDHHC9, establishing a non-canonical function in RAS signaling regulation distinct from vesicle exocytosis.

    Evidence Co-IP of RAB27B and ZDHHC9; Rab27b KO mice with NRAS-mutant hematopoietic cells showed abrogated ERK signaling and reduced leukemia development; NRAS palmitoylation assays

    PMID:37317963

    Open questions at the time
    • Whether RAB27B regulates palmitoylation of other substrates beyond NRAS unknown
    • Structural basis of RAB27B-ZDHHC9 interaction undefined
    • Whether this function is GTP-dependent not shown
  13. 2025 High

    Rab27b was established as essential for lysosomal enzyme maturation in neurons, with its genetic deletion causing lysosomal proteolytic defects and exacerbating alpha-synuclein aggregation and dopaminergic neurodegeneration in multiple in vivo Parkinson's disease models.

    Evidence Rab27b KO mouse neurons with lysosomal enzyme activity assays and pH measurements; A53T transgenic × Rab27b KO and AAV α-syn models showing increased PK-resistant α-syn and nigral cell loss; human PD/DLB brain tissue analysis

    PMID:39965930

    Open questions at the time
    • Whether Rab27b loss is causally linked to human PD remains correlative
    • Specific lysosomal trafficking step regulated by Rab27b in neurons not defined
    • Effector mediating neuronal lysosomal function unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of Rab27b effector selectivity versus Rab27a, the full effector code in each cell type, whether the ZDHHC9-mediated RAS palmitoylation function extends to other substrates, and whether Rab27b loss contributes causally to human neurodegenerative disease.
  • No co-crystal structure of Rab27b with any effector
  • Comprehensive cell-type-specific effector mapping lacking
  • Causal link to human Parkinson's disease not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003924 GTPase activity 3
Localization
GO:0031410 cytoplasmic vesicle 8 GO:0005764 lysosome 4 GO:0005886 plasma membrane 4 GO:0005768 endosome 1 GO:0005829 cytosol 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 8 R-HSA-168256 Immune System 3 R-HSA-109582 Hemostasis 2 R-HSA-112316 Neuronal System 2 R-HSA-162582 Signal Transduction 2 R-HSA-9612973 Autophagy 2
Partners
EXPH5MADDMYO5ASYTL1SYTL3TBC1D10BUNC13DZDHHC9
Complex memberships
Kif5b–Slp3–Rab27bRab27b–Munc13-4Rab27b–Slac2-c/MyRIPRab27b–ZDHHC9

Evidence

Reading pass · 46 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2009 RAB27B controls MVE (multivesicular endosome) docking at the plasma membrane; Rab27b silencing redistributes MVEs toward the perinuclear region, distinct from Rab27a which controls MVE size. The Rab27b effector Slac2b (EXPH5) phenocopies Rab27b silencing and inhibits exosome secretion. RNAi screen in HeLa cells; siRNA silencing; fluorescence microscopy of MVE localization; exosome quantification Nature cell biology High 19966785
2007 Rab27b is required for regulated secretion and correct number of platelet dense granules; Rab27b KO mice exhibit hemorrhagic disease, impaired platelet aggregation, reduced dense granule secretion, and ~50% reduction in dense granule number per platelet. Rab27a partially compensates for the secretory defect but not the reduced granule number. Rab27b knockout mouse generation; crossed with Rab27a ashen KO to produce double KO; in vitro platelet aggregation assays; dense granule secretion assays; electron microscopy Proceedings of the National Academy of Sciences of the United States of America High 17384153
2004 Rab27B localizes to amylase-containing secretory granules in rat parotid acinar cells and forms a complex with the effector Slac2-c/MyRIP on secretory granules in vivo. Disruption of the Rab27B–Slac2-c complex (by recombinant Slp homology domain or blocking antibodies) strongly inhibits isoproterenol-stimulated amylase release. Subcellular fractionation; immunoprecipitation; immunohistochemistry; functional blocking with recombinant protein and antibodies in streptolysin O-permeabilized cells Journal of cell science High 15039459
2007 Rab27b is expressed in a wide range of exocytic cells and is involved in delivering secretory granules near the plasma membrane (the exocytic site). In pituitary double Rab27a/Rab27b KO mice, polarized distribution of secretory granules close to the plasma membrane is markedly impaired. LacZ knock-in reporter mouse for expression analysis; Rab27a/Rab27b double knockout mice generated by crossing; electron microscopy of secretory granule distribution in pituitary cells Molecular biology of the cell High 17761531
2007 Rab27b localizes to secretory granules in mast cells and is required for mast cell degranulation (beta-hexosaminidase release) and passive cutaneous anaphylaxis in vivo. Rab27b-deficient BMMC show ~10-fold increase in granules with fast microtubule-based movement, suggesting Rab27b regulates the transition from microtubule to actin-based granule motility. Rab27b KO and double KO mice; bone marrow-derived mast cell (BMMC) cultures; beta-hexosaminidase release assays; passive cutaneous anaphylaxis in vivo; live-cell time-lapse imaging; nocodazole treatment Traffic (Copenhagen, Denmark) High 17587407
2002 Rab27b associates with secretory granules and the effector granuphilin in pituitary endocrine cells (AtT20). Overexpression of inactive mutant Rab27b N133I significantly inhibits basal and forskolin-induced ACTH secretion. Subcellular fractionation; co-immunoprecipitation with granuphilin; dominant-negative overexpression; ACTH secretion assay Endocrinology High 11956164
2004 Rab27b localizes to zymogen granule membranes in pancreatic acinar cells. Constitutively active Rab27b Q78L enhances CCK-induced amylase release by ~92%, while dominant-negative Rab27b N133I inhibits release by ~53%, demonstrating a role for Rab27b GTP/GDP cycling in pancreatic acinar exocytosis. Proteomics (MALDI-MS/MS) identification; Western blot and immunocytochemistry for localization; adenoviral overexpression of WT, Q78L, and N133I mutants; amylase secretion assay Biochemical and biophysical research communications High 15451418
2003 Rab27b localizes to alpha and dense granules in megakaryocytes. Inhibition of endogenous Rab27 function in primary megakaryocytes causes severe quantitative and qualitative defects in proplatelet formation. NF-E2 transcription factor is recruited to the Rab27B promoter and is required for its expression during terminal megakaryocyte differentiation. Immunofluorescence localization; dominant-negative Rab27 inhibition in primary megakaryocytes; chromatin immunoprecipitation (ChIP) for NF-E2 at Rab27B promoter; analysis of gunmetal mice Blood High 12907454
2003 Rab27b associates with the cytoplasmic face of fusiform vesicles in bladder urothelial umbrella cells and its expression is differentiation-dependent, suggesting a role in targeting uroplakins to the apical plasma membrane. Immuno-electron microscopy; Western blot comparing urothelial tissue vs. cultured cells; differentiation-dependent expression analysis Proceedings of the National Academy of Sciences of the United States of America Medium 14625374
2009 Rab27a and Rab27b both regulate azurophilic granule exocytosis and NADPH oxidase recruitment to the plasma membrane in neutrophils via independent mechanisms. TIRF microscopy shows both isoforms are required for granule docking near the plasma membrane; upregulation of Rab27b in Rab27a-deficient cells does not compensate for the Rab27a secretory defect. Rab27a(ash/ash), Rab27b KO, and double KO mouse neutrophils; azurophilic granule exocytosis assays; TIRF microscopy of granule proximity to plasma membrane; NADPH oxidase activity assay Traffic (Copenhagen, Denmark) High 20028487
2010 RAB27B promotes invasive growth of ER-positive breast cancer cells through GTP- and geranylgeranyl-dependent delivery of secretory vesicles. Mass spectrometry of RAB27B-positive vesicles identified HSP90α as a key cargo; RAB27B-dependent HSP90α secretion is required for MMP-2 activation and invasion. GFP-RAB27B overexpression; point mutants defective in GTP binding or geranylgeranylation; siRNA silencing; Matrigel and collagen invasion assays; mass spectrometry of purified RAB27B vesicles; orthotopic xenograft mouse model Journal of the National Cancer Institute High 20484105
2010 Rab27b is an abundant synaptic vesicle Rab GTPase that, unlike Rab3a, persists on synaptic vesicle membranes upon Ca2+-triggered exocytosis and is resistant to GDI-mediated retrieval. Modulation of the Rab27b GTP/GDP switch impairs synaptic vesicle recycling. Quantitative mass spectrometry (iTRAQ) of synaptic vesicles; quantitative immunoblotting; fluorescence microscopy; GDI extraction assay; Rab27b GTP/GDP switch manipulation The Journal of neuroscience : the official journal of the Society for Neuroscience High 20926670
2013 In mast cells, Rab27a and Rab27b regulate distinct steps of degranulation: Rab27a/Mlph/MyoVa regulates cortical actin stability upstream of granule exocytosis, while Rab27b/Munc13-4 directly mediates granule exocytosis. Munc13-4-deficient mast cells phenocopy the Rab27b KO secretory impairment. Bone marrow-derived mast cells from multiple mutant mouse lines (ashen Rab27a, Rab27b KO, double KO, leaden Mlph KO, dilute MyoVa KO, jinx Munc13-4 KO); beta-hexosaminidase release assays; F-actin immunofluorescence; epistasis analysis The FEBS journal High 23281710
2011 Rab27b regulates stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells. Suppression of Rab27b inhibits fusion of RANKL-containing lysosomal vesicles with the plasma membrane. The effectors Slp4-a, Slp5, and Munc13-4 coordinate Rab27a/b activity in this pathway; Munc13-4-deficient (jinx) mice show increased bone volume due to reduced osteoclast activity. siRNA knockdown of Rab27a, Rab27b, Slp4-a, Slp5, Munc13-4 in osteoblastic cells; RANKL release assays; immunofluorescence of vesicle localization; jinx mouse bone phenotype analysis Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research High 20939018
2007 Crystal structure of mouse Rab27b-GDP reveals an open conformation with protruding switch and interswitch regions, stabilized through domain-swapping dimerization in the crystal. SAXS measurements show an extended monomer in solution, indicating highly flexible switch regions relevant to effector interaction. X-ray crystallography in three distinct crystal lattices; small-angle X-ray scattering (SAXS) Acta crystallographica. Section D, Biological crystallography High 17582168
2012 The Rab27b effector Slac2-b (EXPH5) colocalizes with Rab27b and β4 integrin at early adhesion initiation sites in spreading keratinocytes. Loss-of-function of Slac2-b (frameshift mutation in humans or shRNA knockdown) causes keratinocyte adhesion disruption, cytoskeletal disruption, and increased perinuclear vesicles, establishing a role for the Rab27B–Slac2-b complex in keratinocyte biology. Whole-exome sequencing of human patients; immunofluorescence co-localization; shRNA knockdown in normal keratinocytes; cell adhesion assays American journal of human genetics High 23176819
2011 Rab27b is required for exocytosis of secretory vesicles in lacrimal gland acinar cells. Constitutively active Rab27b increases the average size of secretory vesicles while retaining subapical distribution; dominant-negative Rab27b redistributes Rab27b to cytoplasm. Rab27b KO and double KO mice (but not Rab27a ashen mice) show changes in abundance and organization of secretory vesicles. Disruption of actin filaments inhibits vesicle fusion to the apical membrane but not homotypic fusion. Confocal fluorescence microscopy; transmission electron microscopy of lacrimal gland from KO mice; constitutively active and dominant-negative Rab27b expression; syncollin-GFP secretory protein release assay; actin disruption experiments American journal of physiology. Cell physiology High 21525430
2013 EPI64B (TBC1D10B) functions as a GTPase-activating protein (GAP) specific for Rab27B in pancreatic acinar cells. EPI64B overexpression almost completely abolishes GTP-Rab27b without affecting GTP-Rab3D, and enhances amylase release in a Rab27B-dependent manner. GAP-dead EPI64B mutations block these effects. Adenoviral overexpression in isolated pancreatic acini; GTP-bound Rab27B pulldown; amylase release assay; Rab27b KO mouse acini for epistasis; site-directed mutagenesis of catalytic residues The Journal of biological chemistry High 23671284
2002 Rab27b dominant-negative mutants (T23N and N133I) fail to associate with melanosomes and cause redistribution of melanosomes from cell periphery to perinuclear region in melanocytes, implicating Rab27b in outward movement of melanosomes. Wild-type Rab27b co-localizes with TRP-1 and myosin Va at the cell periphery. Dominant-negative Rab27b also reduces dendrite number and length. GFP-tagged WT and dominant-negative Rab27b overexpression in melan-a melanocytes; confocal co-localization with TRP-1 and myosin Va; dendrite morphology analysis; intrinsic GTPase activity assay The Journal of investigative dermatology Medium 12060386
2004 Rab27b protein is present at extraordinary high levels (0.1% of total protein) on fusiform vesicles in bladder urothelium and is markedly reduced in cultured urothelial cells that fail to form fusiform vesicles, linking Rab27b expression to fusiform vesicle formation/maintenance. Immuno-electron microscopy; Western blot quantification; comparison of differentiated urothelium vs. de-differentiated cultured cells Proceedings of the National Academy of Sciences of the United States of America Medium 14625374
2008 Slp1 (a Rab27 effector protein) interacts with Rab27B in vivo and co-localizes on zymogen granules in pancreatic acinar cells. Slp1 KO mice show increased number of zymogen granules, implicating the Rab27B–Slp1 complex in amylase secretion. Co-immunoprecipitation of Slp1 and Rab27B; co-localization by immunofluorescence; Slp1 KO mouse morphological analysis Archives of biochemistry and biophysics Medium 18477466
2016 Kinesin-1 (Kif5b) is recruited to a Slp3/Rab27b effector complex on mast cell secretory granules in a PI3K-dependent and stimulus-dependent manner. PI3K-dependent formation of the kinesin-1/Slp3/Rab27b complex is required for microtubule-dependent movement of secretory granules toward the exocytic site during mast cell degranulation. Kif5b conditional KO mice; passive systemic anaphylaxis model; BMMC degranulation assays; SG translocation imaging; co-immunoprecipitation of kinesin-1/Slp3/Rab27b; PI3K inhibitor experiments The Journal of cell biology High 27810912
2015 Rab27b mediates shear stress-induced vesicular export of miR-143 from endothelial cells downstream of the KLF2 transcription factor. Rab7a and Rab27b are both required for this extracellular vesicle-based miRNA secretion pathway. Rab27b and Rab7a siRNA knockdown; shear stress stimulation; miR-143 vesicular export quantification in endothelial cells FEBS letters Medium 26348397
2009 After beta-adrenergic stimulation in parotid acinar cells, Rab27B translocates from secretory granules to the subapical region (5 min) and then dissociates into the cytosol (30 min) through binding to GDI (GDP dissociation inhibitor), which extracts GDP-bound Rab27B from membranes. Immunofluorescence time-course after isoproterenol treatment; subcellular fractionation; Rab27B-GDI complex detection in cytosol fractions European journal of oral sciences Medium 19583748
2012 In lacrimal gland acinar cells, RAB27B enrichment occurs early in secretory vesicle formation at a basally-localized 'nascent vesicle site' adjacent to the trans-Golgi network. Transport from this nascent vesicle site to the subapical region requires intact microtubules. RAB27B-enriched vesicles in the subapical cytoplasm acquire Myosin 5C for actin-based motility. YFP-Rab27b live-cell confocal microscopy in rabbit lacrimal gland acinar cells; vesicle pool depletion-repletion protocol; nocodazole treatment; p150Glued co-localization; Myosin 5C co-localization PloS one Medium 22363735
2010 Rab27b localizes to tubulovesicle membranes in gastric parietal cells. Upon stimulation, wild-type Rab27b and constitutively active Rab27b Q78L translocate to the apical membrane, while dominant-negative Rab27b N133I does not. Expression of Rab27b N133I almost completely inhibits acid secretion. Mass spectrometry identification in tubulovesicular fractions; YFP-tagged WT, Q78L, N133I adenoviral expression; fluorescence microscopy of resting and stimulated cells; aminopyrine accumulation acid secretion assay Gastroenterology High 20888820
2004 Rab27b is upregulated in Griscelli syndrome type II melanocytes (lacking Rab27a) and forms a tripartite complex with melanophilin and myosin Va transcripts containing exon F on the melanosome membrane, partially compensating for loss of Rab27a function. Real-time quantitative PCR; Western blot; immunofluorescence co-localization; yeast two-hybrid screening Pigment cell research Medium 15357836
2017 RAB27B controls stretch-induced exocytosis of discoidal/fusiform vesicles (DFVs) in bladder umbrella cells. RAB27A-specific shRNA does not inhibit exocytosis. RAB27B operates in a pathway parallel to and independent of the RAB11A-RAB8A-MYO5B pathway. Whole bladder filling preparation; shRNA-mediated knockdown of RAB27B and RAB27A; hGH-loaded DFV exocytosis assay; dominant-active/dominant-negative RAB11A and RAB8A mutants; Squassh segmentation quantification of RAB27B-positive DFVs American journal of physiology. Cell physiology High 29167152
2016 Rab27b is required for lysosomal exocytosis and surface expression of proteolipid protein (PLP) in oligodendrocytes. Rab27b KD reduces lysosomal exocytosis, decreases PLP surface expression, and reduces myelin-like membrane formation in neuron co-culture. shRNA knockdown of Rab27b in oligodendrocytes; lysosomal exocytosis assays; PLP surface expression measurement; oligodendrocyte-neuron co-culture myelination assay Neuroscience bulletin Medium 27325508
2020 Rab27b regulates alpha-synuclein release, autophagic clearance, and toxicity in neurons. Rab27b KD increases paracrine αsyn toxicity, shifts released αsyn to higher-molecular-weight species, increases insoluble intracellular αsyn, and impairs autophagic flux (reduced LC3 turnover after chloroquine treatment). shRNA knockdown; paracrine αsyn neuronal model; size-exclusion chromatography of released αsyn; immunofluorescence of LC3 puncta; chloroquine autophagic flux assay; Western blot of insoluble αsyn fractions The Journal of biological chemistry Medium 32350025
2023 RAB27B controls NRAS palmitoylation and trafficking to the plasma membrane by interacting with ZDHHC9, a palmitoyl acyltransferase. RAB27B depletion selectively abrogates mutant NRAS-mediated ERK signaling and progenitor cell growth in mice, and reduces myelomonocytic leukemia development. RAB27B is upregulated in CBL- or JAK2-mutated myeloid malignancies. Proteomic studies; co-immunoprecipitation of RAB27B and ZDHHC9; Rab27b KO mice with NRAS mutant hematopoietic cells; NRAS palmitoylation assays; ERK signaling assays; in vivo leukemia model; primary human AML RAB27B depletion The Journal of clinical investigation High 37317963
2021 NRF2 promotes Rab27b expression transcriptionally in urothelial cells, and RAB27B mediates NRF2-dependent UPEC expulsion from urothelial cells. Loss of NRF2 reduces RAB27B expression and impairs UPEC expulsion, increasing bacterial burden both in vitro and in vivo. NRF2 KO and overexpression in urothelial cells; RAB27B expression measurement; UPEC expulsion assays; mouse UTI model; dimethyl fumarate (NRF2 inducer) treatment Cell reports Medium 34686330
2021 FOXO1 transcriptionally regulates RAB27B expression in kidney proximal tubule cells. In high-glucose conditions (mimicking diabetic kidneys), FOXO1 is phosphorylated and inactivated, leading to RAB27B downregulation and decreased exosome secretion. Constitutively active nonphosphorylatable FOXO1 restores RAB27B and exosome secretion. Bioinformatics identification of FOXO1 binding sites in Rab27b promoter; high-glucose treatment of BUMPT cells; RAB27B overexpression rescue; constitutively active FOXO1 overexpression; diabetic mouse model exosome analysis Diabetes Medium 33597203
2023 CaSR activates RAB27B through a PI3K/PKA/mTOR/MADD (guanine nucleotide exchange factor) pathway, promoting secretion of cytokines (IL-6, IL-1β, IL-8, IP-10, RANTES) from breast cancer cells. Rab11A interacts with and activates MADD, a GEF for Rab27A/B, linking endocytic recycling endosomes to Rab27B-regulated secretory vesicles via endosomal PI3K (Vps34 and PI3KC2α). CaSR stimulation assays; PI3K/PKA/mTOR/MADD pharmacological inhibition; Co-immunoprecipitation of Rab11A and MADD; cytokine secretion ELISA; siRNA knockdown of pathway components Cellular signalling Medium 37604243
2020 ZIP4 promotes RAB27B expression through CREB-regulated transcription in pancreatic cancer cells. RAB27B is required for the release of HSP70- and HSP90-associated extracellular vesicles that activate p38 MAPK and induce muscle-wasting gene expression (F-box protein 32, UBR2) in myotubes, causing myofibrillar protein loss and cachexia. ZIP4 shRNA knockdown; CREB inhibition; RAB27B expression measurement; EV isolation and Western blot; C2C12 myotube treatment with conditioned media/EVs; p38 MAPK activation assays; orthotopic pancreatic tumor mouse model Gastroenterology Medium 30342032
2013 V-ATPase (vacuolar H+-ATPase) activity and subunits (V0a1, V0d1) are required for peripheral localization and size of Rab27B-positive secretory vesicles in breast cancer cells. Inhibition of V-ATPase reduces Rab27B-induced invasion, HSP90α secretion, and MMP-2 activation. Mass spectrometry of GFP-Rab27B vesicles identifying V-ATPase subunits; Western blot validation; bafilomycin A1 inhibition; siRNA knockdown of V0a1 and V0d1; invasion and secretion assays International journal of cancer Medium 23390068
2019 β-catenin/Tcf-4 transcriptional activation of RAB27B expression is required for secretion of exosomes from colorectal cancer stem cells. Exosomal miR-146a-5p cargo promotes stemness by targeting Numb in recipient cells. β-catenin/Tcf-4 transcription factor analysis; RAB27B knockdown; exosome secretion quantification; exosomal RNA sequencing; luciferase reporter and rescue assays International journal of cancer Medium 30980673
2012 Rab27b negatively regulates c-kit surface expression in megakaryoblastic cells by promoting autocrine secretion of stem cell factor (SCF). Rab27b knockdown reduces SCF secretion, leading to reduced SCF-induced endolysosomal degradation of c-kit and thus increased c-kit surface expression. shRNA knockdown of Rab27b in CMK cells; c-kit surface expression measurement; SCF secretion assay; bafilomycin lysosome inhibition; flow cytometry Biochemical and biophysical research communications Medium 22349512
2025 Rab27b promotes lysosomal function in neurons by supporting lysosomal enzyme maturation and acidic vesicle trafficking. Rab27b KO in neurons causes lysosomal proteolytic defects, enzymatic dysfunction, and exacerbated alpha-synuclein aggregation upon preformed fibril treatment. Rab27b overexpression enhances lysosomal activity and reduces insoluble αsyn accumulation. Rab27b KO mice; primary neuronal cultures; shRNA KD in αsyn-inducible neuronal model; lysosomal enzyme activity assays; lysosomal pH measurement; αsyn preformed fibril treatment; Rab27b overexpression; brain lysate analysis from postmortem human PD/DLB/iLBD tissue The Journal of neuroscience : the official journal of the Society for Neuroscience High 39965930
2024 TGF-β suppresses RAB27B transcription via SMAD3, reducing exosome release from breast cancer cells. RAB27B depletion or TGF-β treatment increases quantity and alters protein composition of EVs, producing recomposed EVs that inhibit CD8+ T cell-mediated cancer killing. TGF-β treatment; SMAD3 identification as transcriptional repressor of RAB27B; click chemistry proteomics; RAB27B siRNA; exosome quantification; CD8+ T cell cytotoxicity assay Journal of extracellular vesicles Medium 39723610
2020 Rab27b KO in hippocampal mossy fiber (MF)-CA3 synapses completely eliminates long-term potentiation (LTP), an effect rescued by lentiviral re-expression of human Rab27b but not GFP. At SC-CA1 synapses, Rab27b KO increases facilitation. Rab27b and Rab3a act synergistically at presynaptic terminals for LTP expression. Rab27b KO mice; electrophysiology at SC-CA1 and DG-MF hippocampal synapses; frequency facilitation measurement; LTP induction; lentiviral rescue with human Rab27b Physiological reports Medium 32358861
2016 Genetic deletion of Rab27B in pancreatic acinar cells reduces the size of zymogen granules and moderately decreases digestive enzyme secretion, revealing a role in zymogen granule maturation distinct from Rab3D. Rab27B KO mouse model; electron microscopy of zymogen granule size; in vitro secretion assays from isolated acini; comparison with Rab3D Biochemical and biophysical research communications Medium 26845357
2023 KIAA1429 stabilizes RAB27B mRNA through the m6A/YTHDF1 axis in chronic myeloid leukemia cells, promoting RAB27B expression and leukemia cell proliferation and drug efflux. Inhibiting KIAA1429 reduces RAB27B mRNA stability, thereby sensitizing CML cells to imatinib. KIAA1429 knockdown; m6A modification analysis; YTHDF1 interaction; RAB27B mRNA stability assays; proliferation and apoptosis assays; drug resistance assays Genes & diseases Medium 37692484
2025 In neurons, Rab27b KO in A53T alpha-synuclein transgenic mice increases proteinase-K resistant αsyn and phospho-S129 αsyn in cortex, striatum, and substantia nigra, and increases astrocyte/microglial activation. In AAV αsyn model, Rab27b KO accelerates dopaminergic cell loss in the substantia nigra. Rab27b KO × A53T transgenic double mutant mice; AAV αsyn overexpression mouse model; proteinase-K resistance assay; phospho-αsyn immunohistochemistry; glia activation markers; nigral dopaminergic cell counting bioRxiv : the preprint server for biologypreprint Medium 41509326
2025 DDX10 physically interacts with Rab27b through phase separation and promotes Rab27b-mediated exosome secretion of PD-L1 in oral squamous cell carcinoma cells, contributing to T cell exhaustion. Co-immunoprecipitation of DDX10 and Rab27b; DDX10 knockdown; exosome PD-L1 quantification; T cell functional assays Research (Washington, D.C.) Low 40352946
2025 Rab27b in neurons is required for amyloid beta (Aβ) secretion via lysosomal exocytosis in hiPSC-derived neurons. Silencing Rab27b (or Munc13-4) significantly reduces lysosomal fusion events at the plasma membrane and blocks Aβ release into the extracellular space, as visualized by TIRF microscopy. TIRF microscopy of lysosome-plasma membrane fusion events in hiPSC-derived neurons; siRNA knockdown of Rab27b and Munc13-4; nanoscale flow cytometry of released particles bioRxivpreprint Medium bio_10.1101_2025.03.01.640950

Source papers

Stage 0 corpus · 85 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 Rab27a and Rab27b control different steps of the exosome secretion pathway. Nature cell biology 2134 19966785
2010 Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. Journal of the National Cancer Institute 198 20484105
2007 Rab27b regulates number and secretion of platelet dense granules. Proceedings of the National Academy of Sciences of the United States of America 151 17384153
2018 ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells. Gastroenterology 120 30342032
2019 RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer. International journal of cancer 109 30980673
1997 Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. Biochemical and molecular medicine 105 9066979
2018 miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding. Leukemia 95 29479064
2004 The small GTPase Rab27B regulates amylase release from rat parotid acinar cells. Journal of cell science 94 15039459
2007 Rab27b is expressed in a wide range of exocytic cells and involved in the delivery of secretory granules near the plasma membrane. Molecular biology of the cell 92 17761531
2007 Rab27b regulates mast cell granule dynamics and secretion. Traffic (Copenhagen, Denmark) 91 17587407
2009 Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms. Traffic (Copenhagen, Denmark) 88 20028487
2016 MiR-193a-3p and miR-193a-5p suppress the metastasis of human osteosarcoma cells by down-regulating Rab27B and SRR, respectively. Clinical & experimental metastasis 87 26913720
2010 Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience 86 20926670
2002 Involvement of Rab27b in the regulated secretion of pituitary hormones. Endocrinology 82 11956164
2003 A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood 77 12907454
2015 Rab7a and Rab27b control secretion of endothelial microRNA through extracellular vesicles. FEBS letters 69 26348397
2003 Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes. Proceedings of the National Academy of Sciences of the United States of America 69 14625374
2020 Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo. Stem cell research & therapy 62 33317598
2013 Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion. The FEBS journal 62 23281710
2004 Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis. Biochemical and biophysical research communications 59 15451418
2012 Germline Mutation in EXPH5 Implicates the Rab27B Effector Protein Slac2-b in Inherited Skin Fragility. American journal of human genetics 57 23176819
2001 Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. BMC genetics 50 11178108
2013 Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer. International journal of cancer 48 23390068
2008 Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis. Asian journal of andrology 47 18478159
2023 RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia. The Journal of clinical investigation 41 37317963
2010 The secretory small GTPase Rab27B as a marker for breast cancer progression. Oncotarget 39 21304180
2004 Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. Pigment cell research 39 15357836
2021 NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression. Cell reports 38 34686330
2016 Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex. The Journal of cell biology 37 27810912
2017 MiR-20a-5p promotes radio-resistance by targeting Rab27B in nasopharyngeal cancer cells. Cancer cell international 36 28265202
2017 Effects of Rab27A and Rab27B on Invasion, Proliferation, Apoptosis, and Chemoresistance in Human Pancreatic Cancer Cells. Pancreas 34 28902788
2020 Oncogenic effects of RAB27B through exosome independent function in renal cell carcinoma including sunitinib-resistant. PloS one 32 32379831
2020 The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of α-synuclein. The Journal of biological chemistry 31 32350025
2017 RAB27A, RAB27B and VPS36 are downregulated in advanced prostate cancer and show functional relevance in prostate cancer cells. International journal of oncology 30 28197629
2011 Rab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 30 20939018
2002 Rab27b association with melanosomes: dominant negative mutants disrupt melanosomal movement. The Journal of investigative dermatology 29 12060386
2020 Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux. Carcinogenesis 27 32390047
2011 Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. American journal of physiology. Cell physiology 27 21525430
2020 Androgen Receptor Signaling Reduces the Efficacy of Bacillus Calmette-Guérin Therapy for Bladder Cancer via Modulating Rab27b-Induced Exocytosis. Molecular cancer therapeutics 26 32737155
2016 Rab27b is Involved in Lysosomal Exocytosis and Proteolipid Protein Trafficking in Oligodendrocytes. Neuroscience bulletin 25 27325508
2019 Inactivation of Rab27B-dependent signaling pathway by calycosin inhibits migration and invasion of ER-negative breast cancer cells. Gene 23 31002890
2021 FOXO1-Mediated Downregulation of RAB27B Leads to Decreased Exosome Secretion in Diabetic Kidneys. Diabetes 22 33597203
2018 MicroRNA-599 suppresses glioma progression by targeting RAB27B. Oncology letters 22 29963197
2007 Structure of the small GTPase Rab27b shows an unexpected swapped dimer. Acta crystallographica. Section D, Biological crystallography 22 17582168
2006 Expression of RAB27B is up-regulated in senescent human cells. Mechanisms of ageing and development 20 16620919
2023 Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer. Cancer genomics & proteomics 19 36581340
2009 Redistribution of small GTP-binding protein, Rab27B, in rat parotid acinar cells after stimulation with isoproterenol. European journal of oral sciences 19 19583748
2023 RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment. Leukemia 18 38036630
2008 Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion. Archives of biochemistry and biophysics 18 18477466
2017 RAB27B requirement for stretch-induced exocytosis in bladder umbrella cells. American journal of physiology. Cell physiology 17 29167152
2020 The Small GTPases Rab27b Regulates Mitochondrial Fatty Acid Oxidative Metabolism of Cardiac Mesenchymal Stem Cells. Frontiers in cell and developmental biology 15 32351955
2013 EPI64B acts as a GTPase-activating protein for Rab27B in pancreatic acinar cells. The Journal of biological chemistry 15 23671284
2021 The calcium sensing receptor (CaSR) promotes Rab27B expression and activity to control secretion in breast cancer cells. Biochimica et biophysica acta. Molecular cell research 14 33845096
2017 Overexpression of microRNA-133b reduces myocardial injuries in children with viral myocarditis by targeting Rab27B gene. Cellular and molecular biology (Noisy-le-Grand, France) 14 29096746
2022 RAB27A and RAB27B Expression May Predict Lymph Node Metastasis and Survival in Patients With Gastric Cancer. Cancer genomics & proteomics 13 35985682
2010 Rab27b localizes to the tubulovesicle membranes of gastric parietal cells and regulates acid secretion. Gastroenterology 13 20888820
2023 The m6A regulator KIAA1429 stabilizes RAB27B mRNA and promotes the progression of chronic myeloid leukemia and resistance to targeted therapy. Genes & diseases 11 37692484
2021 Silencing of long non-coding RNA SNHG15 suppresses proliferation, migration and invasion of pancreatic cancer cells by regulating the microRNA-345-5p/RAB27B axis. Experimental and therapeutic medicine 10 34594410
2023 RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion. Cancer research communications 9 37077938
2023 Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure. Platelets 9 37139869
2020 Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission. Physiological reports 9 32358861
2022 RAB27B inhibits proliferation and promotes apoptosis of leukemic cells via 3-Hydroxy butyrate dehydrogenase 2 (BDH2). Bioengineered 8 35164665
2020 Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma. Neuro-oncology advances 8 33409495
2012 Direct imaging of RAB27B-enriched secretory vesicle biogenesis in lacrimal acinar cells reveals origins on a nascent vesicle budding site. PloS one 8 22363735
2020 Inhibition of Rab27a and Rab27b Has Opposite Effects on the Regulation of Hair Cycle and Hair Growth. International journal of molecular sciences 7 32784729
2012 An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue. The International journal of developmental biology 7 22811270
2023 Rab27b promotes endometriosis by enhancing invasiveness of ESCs and promoting angiogenesis. American journal of reproductive immunology (New York, N.Y. : 1989) 6 37641372
2021 Rab27b regulates extracellular vesicle production in cells infected with Kaposi's sarcoma-associated herpesvirus to promote cell survival and persistent infection. Journal of microbiology (Seoul, Korea) 6 33877577
2016 Genetic deletion of Rab27B in pancreatic acinar cells affects granules size and has inhibitory effects on amylase secretion. Biochemical and biophysical research communications 6 26845357
2012 Rab27b regulates c-kit expression by controlling the secretion of stem cell factor. Biochemical and biophysical research communications 6 22349512
2024 TGF-β regulates the release of breast cancer cell-derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression. Journal of extracellular vesicles 5 39723610
2025 Rab27b Promotes Lysosomal Function and Alpha-Synuclein Clearance in Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 4 39965930
2023 CaSR links endocytic and secretory pathways via MADD, a Rab11A effector that activates Rab27B. Cellular signalling 4 37604243
2024 Tectoridin inhibits the growth of bladder cancer by regulating PI3K/MAPK pathway through RAB27B. Molecular carcinogenesis 3 38441297
2024 Regulation of autophagy by Rab27B in colorectal cancer. The international journal of biochemistry & cell biology 3 39542128
2025 DDX10 Exacerbates Exosomal PD-L1-Dependent T Cell Exhaustion via Phase Separation of Rab27b in Oral Squamous Cell Carcinoma. Research (Washington, D.C.) 2 40352946
2025 Rab27b-mediated CAFs derived exosomal miR-22-3p suppresses ferroptosis and promotes cisplatin resistance in osteosarcoma. Cellular signalling 2 40972800
2020 Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communication. The international journal of biochemistry & cell biology 2 33285290
2025 Mechanism of LINC01018/miR-182-5p/Rab27B in the immune escape through PD-L1-mediated CD8+ T cell suppression in glioma. Biology direct 1 40399992
2025 Microgravity-driven Rab27B activation amplifies mesenchymal stem cell-derived extracellular vesicle production and functions. Stem cell research & therapy 1 41163097
2024 Rab27b promotes lysosomal function and alpha-synuclein clearance in neurons. bioRxiv : the preprint server for biology 1 38979346
2025 Positive feedback loop between NRASQ61R mutation and RAB27B expression in endothelial cells. Biochemical and biophysical research communications 0 39899936
2025 Lichong Decoction represses colorectal cancer progression via inhibiting the PINK1/Parkin pathway regulated by Rab27B. Journal of ethnopharmacology 0 40441460
2025 [Retracted] Silencing of long non-coding RNA SNHG15 suppresses proliferation, migration and invasion of pancreatic cancer cells by regulating the microRNA-345-5p/RAB27B axis. Experimental and therapeutic medicine 0 40692767
2025 Knockout of Rab27b exacerbates neuropathology in alpha-synuclein mouse models. bioRxiv : the preprint server for biology 0 41509326