Affinage

PISD

Phosphatidylserine decarboxylase proenzyme, mitochondrial · UniProt Q9UG56

Length
409 aa
Mass
46.7 kDa
Annotated
2026-04-28
78 papers in source corpus 18 papers cited in narrative 18 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PISD encodes phosphatidylserine decarboxylase, the inner mitochondrial membrane enzyme that converts phosphatidylserine (PS) to phosphatidylethanolamine (PE) through an autocatalytic self-processing mechanism that generates the active pyruvoyl-containing heteromer (PMID:30858161, PMID:16192276). Mitochondrial PE produced by PISD is essential for maintaining mitochondrial cristae morphology, electron transport chain integrity (complexes I and IV), and mitochondrial respiration, and cannot be fully compensated by the CDP-ethanolamine pathway; PS substrate is delivered to the IMM by the conserved SLMO/SLMO2 lipid transfer protein (PMID:16192276, PMID:39680501, PMID:41360863). PISD-derived PE also supports autophagosome membrane biogenesis downstream of mTOR inhibition, regulates ferroptosis susceptibility via a STAT3–GPX4 axis, and controls mPTP opening through SPG7 (PMID:30157433, PMID:41899452, PMID:40780696). Loss-of-function PISD variants cause Liberfarb syndrome, a multisystem disorder featuring retinal degeneration, sensorineural hearing loss, microcephaly, and skeletal dysplasia (PMID:31263216, PMID:30488656).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2002 Medium

    Before direct characterization, PISD enzymatic activity was shown to exhibit tissue- and age-dependent substrate selectivity in brain mitochondria, establishing that PS decarboxylation is not uniform across tissues.

    Evidence In vitro enzymatic activity assays with defined PS substrates from rat cerebellar and cortical mitochondrial fractions

    PMID:12391587

    Open questions at the time
    • Single lab biochemical study
    • No genetic perturbation to confirm in vivo relevance
    • Molecular basis of substrate selectivity unknown
  2. 2005 High

    Genetic ablation established that PISD-dependent mitochondrial PE synthesis is essential for embryonic viability and normal mitochondrial morphology, and that the CDP-ethanolamine pathway cannot compensate during development.

    Evidence PISD knockout mice with EM, confocal microscopy, and radiolabeled PE synthesis assays

    PMID:16192276

    Open questions at the time
    • Mechanism by which PE loss causes mitochondrial fragmentation not defined
    • Cell-type-specific requirements not resolved
    • Whether partial loss of function is tolerable in vivo unknown
  3. 2018 High

    PISD was linked to autophagosome biogenesis: mitochondrial PE produced at MAM contact sites supports LC3-II lipidation and autophagy flux downstream of mTOR inhibition, connecting mitochondrial phospholipid metabolism to autophagy.

    Evidence Complex I-deficient cells, mTOR inhibitor treatment, MAM quantification, phospholipid mass spectrometry, and autophagy flux assays

    PMID:30157433

    Open questions at the time
    • Direct PE transfer from mitochondria to autophagosomes not demonstrated
    • Whether PISD-derived PE is specifically required versus total cellular PE unclear
  4. 2018 Medium

    Human disease mutations were shown to impair PISD function: a p.Cys266Tyr variant caused mitochondrial fragmentation and apoptotic sensitivity in patient fibroblasts, rescued by ethanolamine supplementation, while a founder deletion caused Liberfarb syndrome through aberrant splicing.

    Evidence Trio-exome sequencing, patient fibroblast functional assays, minigene splicing assays, ethanolamine rescue

    PMID:30488656 PMID:31263216

    Open questions at the time
    • Limited number of families studied
    • Genotype-phenotype correlation across the mutation spectrum incomplete
    • No animal model recapitulating Liberfarb syndrome phenotype
  5. 2019 High

    The autocatalytic self-processing mechanism of PISD was directly demonstrated as required for enzymatic activity: a paternal variant impaired proenzyme cleavage while a maternal variant caused aberrant splicing, and both lyso-PE supplementation and genetic complementation rescued mitochondrial and lysosomal morphology.

    Evidence PS-to-PE conversion assays in patient fibroblasts, autocatalytic processing analysis, oxygen consumption measurement, lyso-PE rescue

    PMID:30858161

    Open questions at the time
    • Structural determinants of autocatalytic cleavage in human PISD not resolved at atomic level
    • Whether processing intermediates have regulatory roles unknown
  6. 2021 High

    An alternatively spliced PISD isoform (PISD-LD) was discovered to target lipid droplets rather than mitochondria, with nutritional state controlling isoform localization, expanding PISD function beyond mitochondria to triacylglycerol metabolism.

    Evidence Splice variant characterization, subcellular fractionation, fluorescence localization under lipid storage versus consumption conditions, siRNA depletion

    PMID:33593792

    Open questions at the time
    • Enzymatic activity and substrate specificity of PISD-LD on lipid droplets not characterized
    • Physiological significance of dual targeting in vivo unknown
  7. 2024 High

    The conserved PS delivery pathway to PISD was reconstituted: SLMO/SLMO2 transfers PS from the OMM to the IMM inner boundary membrane domain, establishing a PSS→SLMO→PISD genetic pathway required for mitochondrial morphology.

    Evidence Forward genetic screen in Drosophila, epistasis analysis, human SLMO2 complementation, mitochondrial morphology assays

    PMID:39680501

    Open questions at the time
    • Biochemical mechanism of SLMO-mediated PS transfer not resolved
    • Whether additional lipid transfer proteins contribute in mammalian cells unknown
  8. 2025 Medium

    Downstream signaling axes of PISD-derived PE were defined: PISD depletion reduces STAT3 phosphorylation and GPX4 expression to promote ferroptosis, while PISD overexpression upregulates SPG7 to inhibit mPTP opening and necroptosis, revealing PE as a signaling-competent lipid beyond structural roles.

    Evidence PISD knockdown/overexpression in gastric cancer and HaCaT cells, STAT3/GPX4 immunoblots, lipid peroxidation assays, mPTP opening assays, pharmacological rescue with Fer-1 and ML115

    PMID:40780696 PMID:41899452

    Open questions at the time
    • Whether PE directly modulates STAT3 or acts indirectly through membrane composition changes unknown
    • SPG7 transcriptional regulation by PISD not mechanistically defined
    • Single-lab findings for each axis
  9. 2025 Medium

    PISD deficiency was shown to broadly compromise mitochondrial bioenergetics—reducing ETC complex I/IV abundance, increasing superoxide, promoting fission and mitophagy, and suppressing mTOR-dependent proliferation—while aging reduces ER-mitochondria contacts to limit PS delivery to PISD, impairing autophagy and causing giant mitochondria accumulation.

    Evidence PISD siRNA in hepatocarcinoma cells with Seahorse respiration, ETC immunoblots; aged mouse cardiomyocytes with ER-Mito contact quantification, PE measurement, LACTB modulation

    PMID:40254645 PMID:41360863

    Open questions at the time
    • Relative contribution of reduced PE versus secondary metabolic compensation not dissected
    • LACTB mechanism of PISD enhancement not defined
    • In vivo validation of aging-PISD-autophagy axis in non-cardiac tissues lacking

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the high-resolution structure of mammalian PISD and its autocatalytic mechanism, how PE produced by PISD is distributed from the IMM to autophagosomes and other membranes, the physiological significance of the lipid droplet isoform in vivo, and genotype-phenotype relationships across the spectrum of human PISD variants.
  • No atomic-resolution structure of mammalian PISD
  • PE export route from IMM to extra-mitochondrial membranes undefined
  • PISD-LD isoform function in animal models untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016829 lyase activity 4
Localization
GO:0005739 mitochondrion 4 GO:0005811 lipid droplet 1
Pathway
R-HSA-1430728 Metabolism 6 R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-9612973 Autophagy 3
Partners
LACTBSLMO2SPG7

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 PISD (phosphatidylserine decarboxylase) is essential for mitochondrial morphology and embryonic development; knockout mice die between embryonic days 8–10 with fragmented, misshapen mitochondria, demonstrating that mitochondrial PE synthesis via PS decarboxylation is required for normal mitochondrial structure and cannot be compensated by the CDP-ethanolamine pathway during development. Knockout mouse generation, electron microscopy, fluorescence confocal microscopy, radiolabeled PE synthesis assays, immunoblotting of compensatory pathway enzymes The Journal of biological chemistry High 16192276
2018 PISD activity and mitochondrial-associated membrane (MAM) contacts are required for maximal autophagy induction downstream of mTOR inhibition; complex I dysfunction suppresses autophagy by preventing the increase in MAMs and limiting PISD-dependent mitochondrial PE (mtPE) production needed to support autophagosome biogenesis. Genetic defects in complex I, phenformin treatment, mTOR inhibitor treatment, phospholipid mass spectrometry, MAM quantification, autophagy flux assays Cell reports High 30157433
2018 The missense variant p.(Cys266Tyr) in PISD causes impaired phosphatidylserine decarboxylase function, leading to fragmented mitochondrial morphology in patient fibroblasts and increased apoptotic sensitivity; ethanolamine supplementation restores cell viability, confirming the causal role of reduced PE synthesis. Trio-exome sequencing, patient-derived fibroblast analysis, mitochondrial morphology imaging, caspase-3/7 activation assays, ethanolamine rescue Human mutation Medium 30488656
2019 Compound heterozygous PISD variants cause impaired PS-to-PE conversion in the inner mitochondrial membrane (IMM); one paternal variant impairs autocatalytic self-processing of the PISD precursor required for enzymatic activity, while the maternal variant causes aberrant splicing; lyso-PE supplementation or genetic complementation restores mitochondrial and lysosome morphology. Exome sequencing, PS-to-PE conversion assays in patient fibroblasts, mitochondrial morphology imaging, oxygen consumption rate measurement, lyso-PE rescue, genetic complementation, splice product analysis Life science alliance High 30858161
2019 A founder 10-bp deletion in PISD immediately upstream of the last exon causes aberrant splicing of PISD transcripts in HEK293T cells, establishing loss of functional PISD as the genetic basis of Liberfarb syndrome (retinal degeneration, sensorineural hearing loss, microcephaly, skeletal dysplasia). Exome sequencing, autozygosity mapping, minigene construct splicing assay in HEK293T cells, qPCR, Sanger sequencing of paraffin-embedded tissue Genetics in medicine Medium 31263216
2018 PISD overexpression reduces tumor-initiating potential of breast cancer cells in mammosphere assays and mouse xenograft models and regulates multiple aspects of mitochondrial function; PISD is downregulated ~8-fold in migratory/tumor-initiating cells. Microfluidic migration isolation, whole-transcriptome sequencing, PISD overexpression, mammosphere assay, mouse xenograft model Scientific reports Medium 29321615
2021 PISD localizes to the inner mitochondrial membrane and to lipid droplets via an alternatively spliced isoform (PISD-LD); sub-cellular targeting is controlled by a segment distinct from the catalytic domain and is regulated by nutritional state (lipid storage conditions favor lipid droplet targeting, lipid consumption favors mitochondrial targeting); depletion of both forms impairs triacylglycerol synthesis during fatty acid challenge. Alternative splice variant characterization, sub-cellular fractionation, fluorescence localization, nutritional perturbation, siRNA depletion, triacylglycerol synthesis assay Biology open High 33593792
2020 TFAM knockdown reduces PISD expression through a mechanism involving increased NAD+/NADH ratio, upregulation of SIRT1, deacetylation of p53 at lysine 382, and reduced p53 transcriptional activation of the PISD enhancer; decreased PISD then reduces LC3-II levels and impairs autophagy. TFAM siRNA knockdown, PISD siRNA knockdown, LC3-II immunoblot, NAD+/NADH measurement, SIRT1 activity assay, p53 acetylation analysis, luciferase/ChIP-based transcription assay Cancers Medium 32093281
2021 TGF-β1-induced myofibroblast transition reduces PISD expression in mitochondria; PISD knockdown alone (without TGF-β1) is sufficient to increase α-smooth muscle actin mRNA and collagen production, placing PISD activity upstream of fibrogenesis through phospholipid metabolism. TGF-β1 stimulation, lipidomic analysis, PISD siRNA knockdown, α-SMA mRNA quantification, collagen production assay Journal of clinical biochemistry and nutrition Medium 35400823
2002 Brain mitochondrial PISD (phosphatidylserine decarboxylase) activity shows tissue-dependent and age-dependent substrate preferences based on DHA (22:6n-3) content of the phosphatidylserine substrate; cerebellar PISD activity is specifically inhibited during aging. Mitochondrial fraction isolation from rat cerebral cortex and cerebellum, enzymatic activity assays with PS substrates of defined fatty acid composition Journal of neuroscience research Medium 12391587
2023 PISD downregulation by high uric acid (via inhibited STAT3 phosphorylation) reduces mitochondrial PE levels and impairs mitochondrial respiration, inducing apoptosis; PISD overexpression or lyso-PE supplementation rescues these effects in vitro. Lipidomic analysis of mitochondria, PISD overexpression, lyso-PE supplementation, STAT3 phosphorylation assays, mitochondrial respiration measurement, apoptosis assays MedComm Medium 37502610
2024 SLMO (the Drosophila ortholog of SLMO2) specifically transfers phosphatidylserine from the outer mitochondrial membrane (OMM) to the inner mitochondrial membrane (IMM) within the inner boundary membrane domain, providing substrate for PISD to synthesize PE; genetic evidence places PSS→SLMO→PISD in a conserved pathway required for mitochondrial morphology. Forward genetic screen in Drosophila, epistasis analysis of PSS-SLMO-PISD pathway, mitochondrial morphology assays, SLMO2 human complementation PLoS biology High 39680501
2024 Novel compound heterozygous PISD missense variants p.(Ser190Leu) and p.(His267Tyr) likely impair PISD autocatalytic self-processing and/or PE biosynthesis based on structural homology to E. coli ortholog; patient fibroblasts show significantly higher mitochondrial fragmentation compared to controls. Trio genome sequencing, fibroblast mitochondrial morphology imaging with 2-deoxyglucose stress, structural modeling using E. coli PISD ortholog crystal data Clinical genetics Medium 38801004
2025 PISD deficiency in HEPA1-6 hepatocellular carcinoma cells impairs mitochondrial fatty acid and glucose oxidation, reduces electron transport chain complex I and IV abundance, increases mitochondrial superoxide, augments mitochondrial fission and mitophagy, and reduces cell proliferation via reduced mTOR signaling; peroxisomal fat oxidation and anaerobic glycolysis partially compensate. PISD siRNA silencing, mitochondrial respiration assays (Seahorse), ETC complex abundance (immunoblot), mitochondrial dynamics imaging, cell proliferation assays, mTOR signaling assays Oncogenesis Medium 41360863
2025 PISD depletion in gastric cancer cells reduces PE levels, decreases STAT3 phosphorylation and GPX4 expression, increases lipid peroxidation and iron accumulation, enhancing ferroptosis; Ferrostatin-1, STAT3 activator ML115, or lyso-PE supplementation partially rescues PISD knockdown-induced ferroptosis, defining a PISD→STAT3→GPX4 axis. PISD knockdown, PE quantification, STAT3 phosphorylation immunoblot, GPX4 immunoblot, lipid peroxidation assays, ferroptosis rescue with Fer-1/ML115/LPE, xenograft tumor growth Current issues in molecular biology Medium 41899452
2025 PISD overexpression directly upregulates SPG7 (a critical mPTP component) expression, inhibits mitochondrial permeability transition pore opening, and reverses necroptosis induced by nano-zinc oxide in inflammatory HaCaT cells, establishing a PISD→SPG7→mPTP axis. PISD overexpression, SPG7 overexpression, mPTP opening assay, p-MLKL immunoblot, mitochondrial morphology imaging Toxicology Medium 40780696
2025 Reduction in ER-mitochondria contacts in aged cardiomyocytes impairs PS lipid transport to mitochondria; combined with PISD deficiency, this reduces PE production, impairing autophagosomal membrane formation and autophagic flux, leading to accumulation of dysfunctional giant mitochondria; modulating LACTB expression to enhance PISD activity restores mitochondrial homeostasis. Aged mouse models, etoposide-induced senescence, ER-Mito contact quantification, PE measurement, autophagy flux assays, LACTB manipulation Cell death and differentiation Medium 40254645
2017 Hepatic CDS2 deficiency impairs mitochondrial function and decreases mitochondrial PE levels; PISD overexpression alleviates the NASH-like phenotype in Cds2-deficient mice and normalizes mitochondrial morphology and function, demonstrating that PISD activity downstream of CDS2 maintains mitochondrial PE homeostasis in vivo. Liver-specific Cds2 KO mice, PISD overexpression in vivo, mitochondrial PE measurement, mitochondrial morphology and function assays, NASH phenotype assessment Science bulletin Medium 36546079

Source papers

Stage 0 corpus · 78 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects. The Journal of biological chemistry 221 16192276
1996 Pelvic visceral input into the nucleus gracilis is largely mediated by the postsynaptic dorsal column pathway. Journal of neurophysiology 151 8899637
1984 Postsynaptic dorsal column pathway of the rat. I. Anatomical studies. Journal of neurophysiology 138 6323643
2018 Mitochondrial Complex I Activity Is Required for Maximal Autophagy. Cell reports 89 30157433
1989 Postsynaptic dorsal column pathway of the rat. III. Distribution of ascending afferent fibers. The Journal of neuroscience : the official journal of the Society for Neuroscience 77 2795158
2008 Analytical phase diagrams for colloids and non-adsorbing polymer. Advances in colloid and interface science 65 18783771
2018 The homozygous variant c.797G>A/p.(Cys266Tyr) in PISD is associated with a Spondyloepimetaphyseal dysplasia with large epiphyses and disturbed mitochondrial function. Human mutation 61 30488656
2019 PISD is a mitochondrial disease gene causing skeletal dysplasia, cataracts, and white matter changes. Life science alliance 57 30858161
2013 EBV-miR-BART1 is involved in regulating metabolism-associated genes in nasopharyngeal carcinoma. Biochemical and biophysical research communications 57 23685147
2002 The roles of pathways in the spinal cord lateral and dorsal funiculi in signaling nociceptive somatic and visceral stimuli in rats. Pain 53 11973002
1985 Postsynaptic dorsal column pathway of the rat. II. Evidence against an important role in nociception. Brain research 51 3971159
2003 Fos expression in spinothalamic and postsynaptic dorsal column neurons following noxious visceral and cutaneous stimuli. Pain 42 12855335
2004 The role of dorsal columns pathway in visceral pain. Physiological research 40 15119943
2019 The Liberfarb syndrome, a multisystem disorder affecting eye, ear, bone, and brain development, is caused by a founder pathogenic variant in thePISD gene. Genetics in medicine : official journal of the American College of Medical Genetics 39 31263216
2018 Functional Isolation of Tumor-Initiating Cells using Microfluidic-Based Migration Identifies Phosphatidylserine Decarboxylase as a Key Regulator. Scientific reports 39 29321615
2022 Ts66Yah, a mouse model of Down syndrome with improved construct and face validity. Disease models & mechanisms 35 36374158
2021 Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis. Science bulletin 34 36546079
2019 Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements. Neuron 34 31586516
1999 Comparative study of viscerosomatic input onto postsynaptic dorsal column and spinothalamic tract neurons in the primate. Journal of neurophysiology 34 10515976
2022 Rapid and efficient isolation platform for plasma extracellular vesicles: EV-FISHER. Journal of extracellular vesicles 32 36404468
2015 Evaluation of an α synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson disease. Human vaccines & immunotherapeutics 31 25714663
2023 Luteolin alleviates depression-like behavior by modulating glycerophospholipid metabolism in the hippocampus and prefrontal cortex of LOD rats. CNS neuroscience & therapeutics 30 37715585
2007 Spinal Cord Stimulation Modulates Visceral Nociception and Hyperalgesia via the Spinothalamic Tracts and the Postsynaptic Dorsal Column Pathways: A Literature Review and Hypothesis. Neuromodulation : journal of the International Neuromodulation Society 29 22150836
2023 Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8+ T cells. Nature communications 25 37880206
2023 PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation. Molecular carcinogenesis 24 37157950
1990 Propriospinal neurons with ascending collaterals to the dorsal medulla, the thalamus and the tectum: a retrograde fluorescent double-labeling study of the cervical cord of the rat. Experimental brain research 24 2387355
2018 Forkhead-box series expression network is associated with outcome of clear-cell renal cell carcinoma. Oncology letters 22 29805604
2013 Limited RNA editing in exons of mouse liver and adipose. Genetics 21 23410828
2022 Interaction Between Cecal Metabolites and Liver Lipid Metabolism Pathways During Induced Molting in Laying Hens. Frontiers in physiology 19 35677092
2006 Nerve injury-induced tactile allodynia is present in the absence of FOS labeling in retrogradely labeled post-synaptic dorsal column neurons. Pain 19 17156921
2024 Biochemistry and Diseases Related to the Interconversion of Phosphatidylcholine, Phosphatidylethanolamine, and Phosphatidylserine. International journal of molecular sciences 18 39409074
2023 Phosphatidylserine decarboxylase downregulation in uric acid‑induced hepatic mitochondrial dysfunction and apoptosis. MedComm 18 37502610
2013 Proliferative and estrogenic sensitivity of the mammary gland are modulated by isoflavones during distinct periods of adolescence. Archives of toxicology 17 23288143
2007 The role of c-AMP-dependent protein kinase in spinal cord and post synaptic dorsal column neurons in a rat model of visceral pain. Neurochemistry international 17 17320244
2021 Conditional targeting of phosphatidylserine decarboxylase to lipid droplets. Biology open 16 33593792
2008 Effects of general anesthetics on visceral pain transmission in the spinal cord. Molecular pain 12 18973669
2004 Towards developing a protein infrared spectra databank (PISD) for proteomics research. Proteomics 12 15274125
2020 The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1. The Journal of biological chemistry 11 32144202
2002 Age-related changes in central nervous system phosphatidylserine decarboxylase activity. Journal of neuroscience research 11 12391587
2025 Age-associated reduction in ER-Mitochondrial contacts impairs mitochondrial lipid metabolism and autophagosome formation in the heart. Cell death and differentiation 10 40254645
2001 Somatic noxious mechanical stimulation induces Fos expression in the postsynaptic dorsal column neurons in laminae III and IV of the rat spinal dorsal horn. Neuroscience research 10 11463480
2024 Mitochondrial bioenergetics stimulates autophagy for pathological MAPT/Tau clearance in tauopathy neurons. Autophagy 9 39171695
2023 Proteomics reveals mitochondrial dysfunction and energy metabolism disturbance of intestine in a nonhuman primate model of depression. Journal of affective disorders 9 37080496
2023 Postsynaptic dorsal column pathway activation during spinal cord stimulation in patients with chronic pain. Frontiers in neuroscience 9 38188030
1983 Neuronal organization in the dorsal horn of the spinal cord. Acta morphologica Hungarica 8 6312776
2022 Suppressing Syndecan-1 Shedding to Protect Against Renal Ischemia/Reperfusion Injury by Maintaining Polarity of Tubular Epithelial Cells. Shock (Augusta, Ga.) 7 34313252
2010 A parallel and incremental algorithm for efficient unique signature discovery on DNA databases. BMC bioinformatics 7 20230647
2021 Metabolic changes induced by TGF-β1 via reduced expression of phosphatidylserine decarboxylase during myofibroblast transition. Journal of clinical biochemistry and nutrition 6 35400823
2020 Knockdown of TFAM in Tumor Cells Retarded Autophagic Flux through Regulating p53 Acetylation and PISD Expression. Cancers 6 32093281
2010 NK-1-receptor-mediated lesion of spinal post-synaptic dorsal column neurons might improve intractable visceral pain of cancer origin. Medical hypotheses 6 20826067
2018 Punctate Midline Myelotomy Reduces Pain Responses in a Rat Model of Lumbar Spine Pain: Evidence that the Postsynaptic Dorsal Column Pathway Conveys Pain from the Axial Spine. Cureus 5 29805940
2010 Upper thoracic postsynaptic dorsal column neurons conduct cardiac mechanoreceptive information, but not cardiac chemical nociception in rats. Brain research 5 20869348
2024 SLMO transfers phosphatidylserine between the outer and inner mitochondrial membrane in Drosophila. PLoS biology 4 39680501
2024 Novel biallelic PISD missense variants cause spondyloepimetaphyseal dysplasia with disproportionate short stature and fragmented mitochondrial morphology. Clinical genetics 3 38801004
2020 Midthoracic Punctate Midline Myelotomy for Treatment of Chronic, Intractable, Nonmalignant, Abdominal Visceral Pain: 2-Dimensional Operative Video. Operative neurosurgery (Hagerstown, Md.) 3 32167141
2022 Mechanism of Lysoforte in Improving Jejuna Morphology and Health in Broiler Chickens. Frontiers in veterinary science 2 35928108
2021 Gonadal lipidomics profile of an ovoviviparity teleost, black rockfish, during gonadal development. Fish physiology and biochemistry 2 33694040
2019 Punctate Midline Myelotomy for Chronic, Intractable, Non-malignant Visceral Pain: A Case Report. Cureus 2 31501723
2017 Characteristics of bone marrow cell dysplasia and its effectiveness in diagnosing myelodysplastic syndrome. Hematology (Amsterdam, Netherlands) 2 28675126
2015 Single high-concentration capsaicin application prevents c-Fos expression in spinothalamic and postsynaptic dorsal column neurons after surgical incision. European journal of pain (London, England) 2 25716421
1995 Regulation of mammalian S-adenosylmethionine decarboxylase as studied in a transient expression system. Biochimica et biophysica acta 2 7999790
2024 Learning clustering-friendly representations via partial information discrimination and cross-level interaction. Neural networks : the official journal of the International Neural Network Society 1 39255633
2024 Rapid Analysis of DEER Signals Including Short Distances. The journal of physical chemistry letters 1 39693563
2024 Genetic and allelic heterogeneity in 248 Indians with skeletal dysplasia. European journal of human genetics : EJHG 1 39706863
2023 Performance Enhancement of Ce0.8Sm0.2O1.9-Supported SOFC by Electrophoretic Formation of Modifying BaCe0.8Sm0.2O3 and Ce0.8Sm0.1Pr0.1O1.9 Layers. Membranes 1 37233545
2026 Strong Self-Off Biosensor Based on Proximity-Induced DNA Strand Displacement Triggered Controlled Release for Dual-Mode Sensitive Analysis of Neuron Specific Enolase. Analytical chemistry 0 41499105
2026 Molecular Dissection of Permanent vs. Reperfused Ischemia: Multi-Omics Divergence and Precision Therapeutic Implications. Current issues in molecular biology 0 41614954
2026 Huangkui capsule mitigates diabetic nephropathy via epigenetic therapy effects. Frontiers in pharmacology 0 41815912
2026 Phosphatidylserine Decarboxylase Promotes Ferroptosis Through STAT3/GPX4 Signaling in Gastric Cancer. Current issues in molecular biology 0 41899452
2025 Targeting mitochondrial phosphatidylethanolamine alters mitochondrial metabolism and proliferation in hepatocellular carcinoma. Research square 0 40709271
2025 Nano polystyrene accelerated the reproductive toxicity induced by the Tris(1,3-dichloro-2-propyl) phosphate via Nhr-69-PISD-Drp-1-mediated mitochondrial fragmentation in Caenorhabditis elegans. Environmental pollution (Barking, Essex : 1987) 0 40744371
2025 Mechanism of PISD/SPG7-mediated mPTP opening in necroptosis of inflammatory HaCaT cells induced by nano-zinc oxide. Toxicology 0 40780696
2025 Multi-omics reveals glucose repression of citric acid catabolism in Pichia kudriavzevii. Applied microbiology and biotechnology 0 40956442
2025 Mechanism of Quercetin alleviated E. coli K88-induced Liver Injury in Broilers. Poultry science 0 40976095
2025 Single-Cell RNA-Seq and Machine Learning Reveal Key Feature Genes of Astrocyte in Perioperative Neurocognitive Disorders. Journal of neuroscience research 0 41074638
2025 Homeostatic response of phospholipid pathways to PCYT2 deficiency and impaired de Novo synthesis of phosphatidylethanolamine. Scientific reports 0 41193595
2025 Restoring mitochondria-endoplasmic reticulum-synapse axis: a proteomic dissection of Rhein's multi-pathway antidepressant mechanism. Biochemical pharmacology 0 41242616
2025 Targeting mitochondrial phosphatidylethanolamine alters mitochondrial metabolism and proliferation in hepatocellular carcinoma. Oncogenesis 0 41360863