Affinage

LACTB

Serine beta-lactamase-like protein LACTB, mitochondrial · UniProt P83111

Length
547 aa
Mass
60.7 kDa
Annotated
2026-06-10
44 papers in source corpus 23 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LACTB is a mitochondrial intermembrane-space serine protein, sequence-related to bacterial penicillin-binding proteins and beta-lactamases, that polymerizes into stable micron-scale filaments and organizes intramitochondrial micro-compartments (PMID:19858488, PMID:11707067). Cryo-EM of human LACTB filaments resolved three assembly interfaces and showed that higher-order helical assembly potentiates catalysis, with the filament-forming residues required for full enzymatic activity; LACTB cleaves peptide bonds adjacent to aspartate and exhibits D-aspartyl endopeptidase activity, and its filaments bind lipid membranes (PMID:35247327, PMID:36534696, PMID:40286848). The enzyme acts on mitochondrial lipid metabolism: it cleaves and activates PLA2G6 to convert oxidized phosphatidylethanolamine to lyso-phosphatidylethanolamine, and lowers phosphatidylserine decarboxylase (PISD) levels, thereby reshaping mitochondrial phospholipid pools, regulating ferroptosis, and driving cancer-cell differentiation (PMID:28329758, PMID:39561766). LACTB preferentially binds and remodels cardiolipin-enriched inner-membrane nanotubes and is required for apoptosis-associated inner-membrane remodeling that facilitates cytochrome c release, independent of BAX/Drp1 recruitment and OPA1 processing (PMID:41223265). In cancer it predominantly behaves as a tumor suppressor, stabilizing p53 by excluding MDM2 and triggering p53-dependent ferroptosis programs (PMID:29899406, PMID:39047638). Its proteolytic activity is restrained by post-translational succinylation: OXCT1 succinylates LACTB at K284 to inhibit catalysis and support tumor mitochondrial respiration (PMID:38176415). LACTB also functions as a metabolic hydrolase, hydrolyzing succinylcarnitine in myeloid cells and influencing CPT2-dependent hepatic lipid handling (PMID:41929023, PMID:41527692).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2001 Medium

    Established LACTB as a candidate mammalian serine enzyme by recognizing its active-site motif and homology to bacterial beta-lactamases/penicillin-binding proteins, framing it as a potential protease rather than an uncharacterized ORF.

    Evidence Sequence analysis, cDNA cloning, and Northern blot expression profiling

    PMID:11707067

    Open questions at the time
    • No enzymatic activity or substrate demonstrated
    • Subcellular localization not defined
  2. 2009 High

    Resolved where LACTB acts and how it is organized, showing it localizes to the mitochondrial intermembrane space and self-assembles into stable filaments that compartmentalize the mitochondrion.

    Evidence Subcellular fractionation and electron microscopy

    PMID:19858488

    Open questions at the time
    • Filament assembly determinants unresolved
    • No catalytic role linked to filamentation yet
  3. 2017 High

    Connected LACTB to a defined cellular phenotype, demonstrating it suppresses breast cancer proliferation by lowering PISD and rewiring mitochondrial phosphatidylethanolamine synthesis to induce differentiation.

    Evidence Overexpression/knockdown, mouse models, and lipidomics with PISD quantification

    PMID:28329758

    Open questions at the time
    • Mechanism by which LACTB reduces PISD not defined
    • Direct protease substrate not identified
  4. 2018 Medium

    Provided a non-lipid tumor-suppressive mechanism, showing LACTB binds the p53 C terminus and blocks MDM2 to stabilize p53 in wild-type-TP53 colorectal cancer.

    Evidence Reciprocal Co-IP, CRISPR knockout, and p53-null rescue

    PMID:29899406

    Open questions at the time
    • Whether protease activity is required for p53 stabilization unclear
    • Single-lab data
  5. 2022 High

    Defined the structural basis of LACTB catalysis, showing filament assembly via three interfaces potentiates D-aspartate-adjacent peptide bond cleavage and that filaments bind lipid membranes.

    Evidence Cryo-EM at 2.8–3.1 Å, site-directed mutagenesis, enzyme and lipid-binding assays (two independent studies)

    PMID:35247327 PMID:36534696

    Open questions at the time
    • Physiological protein substrates not identified from structure
    • How membrane binding couples to proteolysis unresolved
  6. 2022 Medium

    Linked LACTB to cell death and stress output, showing its expression causes G1 arrest and mitochondrial ROS-driven caspase-independent death in breast cancer.

    Evidence Protein array, flow cytometry, immunofluorescence, and in vivo assays

    PMID:36282364

    Open questions at the time
    • Molecular trigger of ROS increase undefined
    • Relationship to its lipid-metabolic role unclear
  7. 2023 Medium

    Revealed upstream regulation and a ferroptosis output, showing PCBP1 degrades LACTB mRNA and that LACTB promotes erastin-induced ferroptosis through PISD downregulation.

    Evidence RNA pull-down, RIP, luciferase reporter, JC-1 staining, and PISD rescue

    PMID:37157950

    Open questions at the time
    • Direct enzymatic basis of PISD reduction unresolved
    • Single-lab epistasis
  8. 2024 High

    Identified a direct succinylation switch, showing OXCT1 succinylates LACTB at K284 to inhibit its proteolytic activity and enhance tumor mitochondrial respiration.

    Evidence In vitro succinyltransferase reconstitution, mass spectrometry, and mutagenesis of OXCT1 G424 and LACTB K284

    PMID:38176415

    Open questions at the time
    • Desuccinylase for K284 not identified
    • Effect on filament assembly not tested
  9. 2024 High

    Pinpointed a bona fide LACTB protease substrate, showing it cleaves and activates PLA2G6 to convert oxidized PE to lyso-PE, with PLA2G6 deletion abolishing LACTB's protective effect against kidney injury.

    Evidence Mouse knockout/overexpression, in vivo genetic epistasis (PLA2G6 KO rescue), lipidomics, and in vitro protease assay

    PMID:39561766

    Open questions at the time
    • Whether PLA2G6 activation explains the cancer phenotypes untested
    • Filament dependence of PLA2G6 cleavage unknown
  10. 2024 Medium

    Extended the p53 axis to ferroptosis, showing LACTB represses HSPA8 transcription in a p53-dependent manner to elevate ferritinophagy and inhibit SLC7A11/GPX4 signaling in liver cancer.

    Evidence Overexpression/knockout, pathway marker analysis, and p53 binding-site mutation

    PMID:39047638

    Open questions at the time
    • Direct vs indirect transcriptional control of HSPA8 unresolved
    • How a mitochondrial protease controls nuclear transcription unclear
  11. 2024 Medium

    Demonstrated context-dependent oncogenic conversion, showing osteosarcoma-prevalent M5L+R469K mutations make LACTB reduce wild-type p53 and protect mutant p53, with clavulanate blocking this activity.

    Evidence Mutant LACTB constructs, PSMB7 activity and proteasomal/lysosomal degradation assays, and drug-binding assays

    PMID:39324579

    Open questions at the time
    • Structural impact of mutations on catalysis untested
    • Single-lab mechanistic model
  12. 2025 High

    Established a direct membrane-remodeling role in apoptosis, showing LACTB binds and remodels cardiolipin-enriched inner-membrane nanotubes to facilitate cytochrome c release independent of BAX/Drp1 and OPA1 processing.

    Evidence Knockdown/overexpression, cytochrome c release assays, and purified-protein lipid remodeling on cardiolipin nanotubes

    PMID:41223265

    Open questions at the time
    • Whether proteolytic activity is needed for membrane remodeling unresolved
    • Upstream apoptotic signal that engages LACTB undefined
  13. 2025 High

    Defined LACTB's catalytic specificity at the chemical level, establishing it as a D-aspartyl endopeptidase that cleaves at the C terminus of D-aspartate residues.

    Evidence In vitro enzymatic assays with D-Asp-containing peptide substrates and structural comparison with bacterial paenidase

    PMID:40286848

    Open questions at the time
    • Endogenous D-Asp-containing substrates in vivo not identified
    • Physiological role of DAEP activity unknown
  14. 2025 Medium

    Added a transcriptional-regulatory circuit and a fusion-machinery target, showing acetylated KLF5 represses LACTB while LACTB destabilizes OMA1 to modulate OPA1-mediated fusion and colorectal stemness.

    Evidence ChIP/protein-DNA assays, Co-IP, CRISPR knockout, and KLF5 acetylation-mimic mutants

    PMID:41213373

    Open questions at the time
    • Direct vs indirect OMA1 destabilization unresolved
    • Single-lab data
  15. 2026 Medium

    Broadened LACTB's biochemistry to small-molecule metabolism, identifying it as the primary succinylcarnitine hydrolase in myeloid cells and as a regulator of CPT2 stability in hepatic lipid handling.

    Evidence Enzymatically-dead mouse model, KO microglia, metabolomics/lipidomics (preprint) and Co-IP with CPT2-dependent in vivo rescue

    PMID:41527692 PMID:41929023

    Open questions at the time
    • Succinylcarnitine hydrolysis result is from a preprint
    • Whether one active site supports both peptidase and ester-hydrolase activities untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How LACTB's single catalytic activity and filament state are switched among its many outputs — phospholipid remodeling, ferroptosis, p53 stabilization, membrane remodeling, and metabolite hydrolysis — and which functions are direct protease-dependent versus indirect remains unresolved.
  • No unified model linking filament assembly, substrate choice, and tissue-specific phenotypes
  • Most cancer mechanisms lack a defined direct protease substrate

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0016787 hydrolase activity 3 GO:0140096 catalytic activity, acting on a protein 3 GO:0008289 lipid binding 2
Localization
GO:0005739 mitochondrion 3
Pathway
R-HSA-1430728 Metabolism 3 R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-5357801 Programmed Cell Death 2
Partners
CPT2OXCT1PIK3R3PLA2G6PP1ATP53
Complex memberships
LACTB filament

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2009 LACTB is localized in the mitochondrial intermembrane space, where it polymerizes into stable filaments extending more than a hundred nanometers, promoting intramitochondrial membrane organization and micro-compartmentalization. Subcellular fractionation, electron microscopy, direct localization experiment Proceedings of the National Academy of Sciences of the United States of America High 19858488
2001 LACTB is a mammalian active-site serine protein with sequence similarity to bacterial penicillin-binding proteins/beta-lactamases, containing an active site motif related to C-class beta-lactamases and a predicted amino-terminal transmembrane domain. Sequence analysis, cDNA cloning, Northern blot expression analysis Genomics Medium 11707067
2017 LACTB potently inhibits breast cancer cell proliferation by altering mitochondrial lipid metabolism; mechanistically, it reduces levels of mitochondrial phosphatidylserine decarboxylase (PISD), which is involved in the synthesis of mitochondrial phosphatidylethanolamine, thereby inducing breast cancer cell differentiation. In vitro overexpression/knockdown, in vivo mouse models, lipidomics, PISD protein level measurement Nature High 28329758
2018 LACTB directly binds the C terminus of p53 and inhibits p53 degradation by preventing MDM2 from interacting with p53, thereby stabilizing p53 and exerting tumor-suppressive effects in colorectal cancer cells with wild-type TP53. Co-immunoprecipitation, CRISPR/Cas9 knockout, ectopic expression, Western blot, p53-null cell lines Oncogene Medium 29899406
2020 LACTB regulates PIK3R3 activity to influence PI3K levels, thereby promoting autophagy and inhibiting EMT and proliferation through the PI3K/AKT/mTOR signaling pathway in colorectal cancer cells. RNA-seq, immunoprecipitation, Western blot, Transwell invasion assay, xenograft model Cancer management and research Medium 32636680
2021 LACTB directly binds PP1A (protein phosphatase 1A) and attenuates the interaction between PP1A and YAP, resulting in increased YAP phosphorylation at Ser127, decreased YAP nuclear translocation, and YAP inactivation in a LATS1-independent manner, thereby suppressing melanoma progression. Co-immunoprecipitation, overexpression, phospho-YAP detection by Western blot, phosphorylation-defective YAP mutant rescue, in vivo xenograft Cancer letters Medium 33675985
2022 Cryo-electron microscopy structures of human LACTB filaments at 2.8–3.1 Å resolution revealed that three interfaces are required for filament assembly, formation of higher-order helical structures facilitates cleavage activity, and the middle region is necessary for substrate hydrolysis but not filament formation; LACTB specifically cleaves peptide bonds adjacent to aspartic acid residues. Cryo-electron microscopy, site-directed mutagenesis, enzymatic activity assays, inhibitor-bound structure (Z-AAD-CMK) Structure (London, England : 1993) High 35247327
2022 Human LACTB self-assembles into micron-scale filaments that increase catalytic activity; residues at the filament-forming interface are required for filamentation, and mutations disrupting filamentation reduce enzyme activity; LACTB filaments can bind lipid membranes. Cryo-EM, site-directed mutagenesis, enzyme activity assays, lipid-binding assays PLoS biology High 36534696
2022 LACTB expression leads to cell cycle arrest in G1 phase and increased mitochondrial reactive oxygen species production, which causes DNA oxidation and activation of an intrinsic caspase-independent cell death pathway in breast cancer cells. Protein array, flow cytometry, Western blot, immunofluorescence, cell proliferation assays, 2D/3D cell culture, in vivo experiments Apoptosis : an international journal on programmed cell death Medium 36282364
2023 PCBP1 directly binds LACTB mRNA and promotes its degradation; LACTB upregulation promotes erastin-induced ferroptosis and mitochondrial dysfunction; the ferroptosis-promoting effect of LACTB is mediated through downregulation of PISD (phosphatidylserine decarboxylase), as PISD overexpression reverses LACTB-mediated ferroptosis. RNA pull-down, RNA immunoprecipitation, luciferase reporter assay, flow cytometry, JC-1 staining, xenograft model Molecular carcinogenesis Medium 37157950
2024 OXCT1 functions as a lysine succinyltransferase (with residue G424 essential for this activity) and succinylates LACTB at lysine K284; this succinylation inhibits LACTB proteolytic activity, resulting in increased mitochondrial membrane potential and respiration, promoting hepatocellular carcinoma progression. In vitro succinyltransferase assay, mass spectrometry, site-directed mutagenesis (G424 in OXCT1; K284 in LACTB), Western blot, enzymatic activity assay Molecular cell High 38176415
2024 LACTB is a novel mitochondrial protease that cleaves and activates phospholipase A2 group VI (PLA2G6); LACTB and downstream PLA2G6 convert oxidized phosphatidylethanolamine to lyso-phosphatidylethanolamine, thereby regulating mitochondrial function and ferroptosis; genetic deletion of PLA2G6 in tubule-specific LACTB-overexpressing mice abolished LACTB's protective function against kidney injury. Mouse knockout/overexpression models, genetic epistasis (PLA2G6 KO rescue), lipidomics in mouse and human, in vitro protease assay Cell metabolism High 39561766
2023 Suclg2 suppresses LACTB succinylation at lysine K288 (mouse numbering) in regulatory dendritic cells (diffDCs); Lactb succinylation at this residue activates NF-κB signaling; Suclg2-mediated prevention of Lactb succinylation is required for maintaining the tolerogenic function of diffDCs. Metabolomics, transcriptomics, functional immune assays, succinylation site identification by mass spectrometry, Suclg2 interference Journal of autoimmunity Medium 37216870
2024 LACTB blocks HSPA8 transcription in a p53-dependent manner in liver cancer; this results in elevation of NCOA4-mediated ferritinophagy and inhibition of SLC7A11/GSH/GPX4 signaling, thereby triggering ferroptosis and suppressing liver cancer progression. Overexpression/knockout experiments, Western blot, in vivo xenograft, GPX4/SLC7A11 pathway analysis, p53 binding site mutation Redox biology Medium 39047638
2025 LACTB is required for apoptosis-induced inner mitochondrial membrane (IMM) remodeling, which facilitates cytochrome c release; LACTB knockdown reduces cytochrome c release and apoptosis, while overexpression promotes these effects; LACTB does not affect BAX or Drp1 recruitment to mitochondria; purified LACTB directly binds and remodels cardiolipin-enriched membrane nanotubes preferentially over planar lipid membranes; LACTB's role in IMM remodeling is independent of OPA1 processing and apoptosis-specific. Knockdown/overexpression, cytochrome c release assay, mitochondrial morphology imaging, purified protein lipid-binding and remodeling assay with cardiolipin-enriched membrane nanotubes Science advances High 41223265
2025 LACTB has D-aspartyl endopeptidase (DAEP) activity, cleaving proteins at the carboxy terminus of D-aspartic acid residues, including a peptide derived from amyloid β1-10 containing D-Asp at position 7; this activity was identified by structural comparison with bacterial paenidase and confirmed by in vitro assay. In vitro enzymatic assay with D-Asp-containing peptide substrates, structural comparison with bacterial DAEP (paenidase) The Journal of biological chemistry High 40286848
2025 Acetylated KLF5 (at lysine 369) acts as a transcriptional repressor of LACTB; LACTB in turn destabilizes OMA1 protein, thereby modulating OPA1-mediated mitochondrial fusion, governing colorectal cancer cell stemness and differentiation. ChIP/protein-DNA interaction assays, Co-IP, CRISPR/Cas9 KO, acetylation mimic/deacetylation mimic KLF5 mutants, Western blot, xenograft model International journal of biological macromolecules Medium 41213373
2026 LACTB is identified as a primary enzyme responsible for succinylcarnitine hydrolysis in myeloid cells; loss of LACTB enzymatic activity (enzymatically-dead mice) elevates succinylcarnitine levels and modulates OXPHOS, lipid profiles, and efferocytosis-related functions in microglia. Mendelian randomization, LACTB KD macrophages, LACTB KO iPSC-derived microglia, enzymatically-dead mouse model, metabolomics, lipidomics, transcriptomics, xenotransplantation bioRxiv (preprint)preprint Medium 41929023
2026 LACTB interacts with CPT2 (carnitine palmitoyltransferase 2) and promotes its ubiquitin-mediated degradation; LACTB overexpression exacerbates hepatic steatosis in high-fat diet mice, and the effect on lipid metabolism is dependent on CPT2. Co-immunoprecipitation, in vivo LACTB KD/overexpression mouse models, Western blot, ubiquitination assay Diabetes, obesity & metabolism Medium 41527692
2010 LACTB was expressed as an N-terminal GST fusion protein in E. coli with confirmed secondary structure (alpha-helices, beta-sheets, turns) by FTIR spectrometry, establishing that the protein can be properly folded for biochemical study. Recombinant protein expression, glutathione-agarose affinity chromatography, MALDI-TOF mass spectrometry, immunoblotting, FTIR spectrometry Protein expression and purification Medium 16202624
2024 Double missense mutations M5L and R469K in LACTB (present in 92.31% of osteosarcoma patients) confer oncogene-like functions: LACTB(M5L+R469K) reduces wild-type p53 by enhancing PSMB7 catalytic activity and protects mutant p53(R156P) from lysosomal degradation; clavulanate potassium binds and blocks LACTB(M5L+R469K) to suppress osteosarcoma proliferation. Overexpression of mutant LACTB constructs, PSMB7 activity assays, p53 degradation assays (proteasomal vs lysosomal), drug binding and proliferation assays Advanced science (Weinheim, Baden-Wurttemberg, Germany) Medium 39324579
2020 In nasopharyngeal carcinoma, LACTB promotes metastasis by activating ERBB3/EGFR-ERK signaling, which in turn affects stability and acetylation of histone H3; LACTB does not influence cellular proliferation in this context. Overexpression/knockdown, in vitro motility assays, in vivo metastasis model, pathway inhibitor studies, histone modification analysis Cancer letters Medium 33152401
2022 LACTB suppresses migration and invasion of glioblastoma by downregulating RHOC expression and inhibiting the RHOC/Cofilin signaling pathway. Overexpression in LN229 and U87 cell lines, migration/invasion assays, Western blot for RHOC and Cofilin pathway markers Biochemical and biophysical research communications Low 36088805

Source papers

Stage 0 corpus · 44 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Nature 153 28329758
2018 LACTB, a novel epigenetic silenced tumor suppressor, inhibits colorectal cancer progression by attenuating MDM2-mediated p53 ubiquitination and degradation. Oncogene 76 29899406
2009 LACTB is a filament-forming protein localized in mitochondria. Proceedings of the National Academy of Sciences of the United States of America 73 19858488
2024 OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB. Molecular cell 68 38176415
2020 LACTB Regulates PIK3R3 to Promote Autophagy and Inhibit EMT and Proliferation Through the PI3K/AKT/mTOR Signaling Pathway in Colorectal Cancer. Cancer management and research 50 32636680
2001 Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain. Genomics 38 11707067
2021 LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction. Cancer letters 33 33675985
2015 MicroRNA-125b-5p attenuates lipopolysaccharide-induced monocyte chemoattractant protein-1 production by targeting inhibiting LACTB in THP-1 macrophages. Archives of biochemistry and biophysics 32 26603571
2017 Overexpression of LACTB, a Mitochondrial Protein That Inhibits Proliferation and Invasion in Glioma Cells. Oncology research 30 28835318
2020 LACTB promotes metastasis of nasopharyngeal carcinoma via activation of ERBB3/EGFR-ERK signaling resulting in unfavorable patient survival. Cancer letters 27 33152401
2023 PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation. Molecular carcinogenesis 24 37157950
2024 LACTB suppresses liver cancer progression through regulation of ferroptosis. Redox biology 23 39047638
2021 LACTB induced apoptosis of oxaliplatin-resistant gastric cancer through regulating autophagy-mediated mitochondrial apoptosis pathway. American journal of translational research 19 33594312
2020 MicroRNA-1276 Promotes Colon Cancer Cell Proliferation by Negatively Regulating LACTB. Cancer management and research 19 33273855
2005 Expression and purification of the mitochondrial serine protease LACTB as an N-terminal GST fusion protein in Escherichia coli. Protein expression and purification 18 16202624
2023 Metabolic enzyme Suclg2 maintains tolerogenicity of regulatory dendritic cells diffDCs by suppressing Lactb succinylation. Journal of autoimmunity 17 37216870
2022 Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB. Structure (London, England : 1993) 15 35247327
2022 Unveiling the Function of the Mitochondrial Filament-Forming Protein LACTB in Lipid Metabolism and Cancer. Cells 14 35626737
2024 Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome. Cell metabolism 13 39561766
2022 LACTB suppresses carcinogenesis in lung cancer and regulates the EMT pathway. Experimental and therapeutic medicine 13 35222724
2022 The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding. PLoS biology 13 36534696
2020 Pinocembrin Inhibits the Proliferation, Migration, Invasiveness, and Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by Regulating LACTB. Cancer biotherapy & radiopharmaceuticals 12 33395536
2022 LACTB suppresses migration and invasion of glioblastoma via downregulating RHOC/Cofilin signaling pathway. Biochemical and biophysical research communications 10 36088805
2022 LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer. Apoptosis : an international journal on programmed cell death 10 36282364
2021 Targeted Nanotherapeutics Using LACTB Gene Therapy Against Melanoma. International journal of nanomedicine 10 34819728
2022 LACTB, a Metabolic Therapeutic Target in Clinical Cancer Application. Cells 8 36078157
2021 LACTB and LC3 could serve as potential biomarkers of gastric cancer to neoadjuvant chemotherapy with oxaliplatin plus S-1. Oncology letters 8 33907580
2022 LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug. Life science alliance 7 36375842
2024 SNPs Give LACTB Oncogene-Like Functions and Prompt Tumor Progression via Dual-Regulating p53. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 6 39324579
2025 The Pivotal Role of LACTB in the Process of Cancer Development. International journal of molecular sciences 4 39941048
2023 A potential therapeutic approach for gastric cancer: inhibition of LACTB transcript 1. Aging 3 38149985
2025 Discovery and biochemical characterization of the D-aspartyl endopeptidase activity of the serine protease LACTB. The Journal of biological chemistry 2 40286848
2025 Study on the regulation of gastric cancer cell apoptosis by LACTB through mitochondrial autophagy pathway. Scientific reports 2 40603395
2025 A Near-Infrared Fluorescent Probe for Monitoring of LACTB Activity in NSCLC Diagnosis and Therapy. Analytical chemistry 2 40711831
2025 The tumor suppressor LACTB remodels mitochondria to promote cytochrome c release and apoptosis. Science advances 2 41223265
2025 EBV-miR-BART14-3p Targets LACTB to Enhance Gastric Cancer Cell Proliferation and Migration. Biochemical genetics 1 39903432
2025 LACTB promotes cell differentiation and inhibits cell proliferation in colorectal cancer. Biochimica et biophysica acta. General subjects 1 40354832
2021 [Alternative Splicing Analysis of LACTB Gene and Expression Characteristics of Different Transcripts in Leukemia Cell Lines]. Zhongguo shi yan xue ye xue za zhi 1 34362477
2026 The depletion of serine beta-lactamase-like protein (LACTB) ameliorates metabolic dysfunction-associated steatotic liver disease by reducing ubiquitin-mediated degradation of carnitine palmitoyltransferase 2. Diabetes, obesity & metabolism 0 41527692
2026 LINC00852 inhibits colorectal cancer progression by regulating cell apoptosis, epithelial‒mesenchymal transition, invasion, and cuproptosis through miR-1276/LACTB. RNA biology 0 41775345
2026 Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine levels and reduced Alzheimers disease risk. bioRxiv : the preprint server for biology 0 41929023
2026 Fiber type-specific expression of LACTB leverages a function in oxidative metabolism. Histochemistry and cell biology 0 42000972
2025 Acetylated KLF5 inhibits LACTB transcription, mediates mitochondrial dynamics, and regulates colorectal cancer cell stemness and differentiation. International journal of biological macromolecules 0 41213373
2024 Protocol for identifying OXCT1-mediated LACTB succinylation sites in vitro. STAR protocols 0 38787728

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