Affinage

PEX19

Peroxisomal biogenesis factor 19 · UniProt P40855

Length
299 aa
Mass
32.8 kDa
Annotated
2026-04-29
53 papers in source corpus 22 papers cited in narrative 22 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PEX19 is a predominantly cytosolic, farnesylated chaperone and import receptor essential for peroxisomal membrane biogenesis. It binds newly synthesized peroxisomal membrane proteins (PMPs) through their hydrophobic targeting signals via its C-terminal domain—where farnesylation allosterically creates hydrophobic pockets for cargo recognition—stabilizes them against aggregation in the cytosol, and delivers them to the peroxisomal membrane by docking onto PEX3 through its N-terminal domain, with PEX19 Phe29 engaging a hydrophobic groove on PEX3 (PMID:10704444, PMID:14709540, PMID:20554521, PMID:28281558). A conserved PEX19 helix (αd) shields PMP transmembrane domains from cytosolic chaperones and interacts with PEX3 to trigger cargo release at the destination membrane (PMID:38585659). Beyond peroxisomal PMPs, PEX19 mediates targeting of tail-anchored proteins to mitochondria, controls lipid droplet protein composition via a farnesylation-dependent mechanism, and participates in a dynamic Msp1-dependent quality-control cycle that re-routes mistargeted membrane proteins back to peroxisomes (PMID:30033679, PMID:35557938, PMID:40344504).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1999 High

    Identification of PEX19 as a farnesylated protein required for an early step of peroxisome membrane assembly established the gene's foundational role upstream of matrix protein import.

    Evidence Functional complementation of CHO mutant ZP119, patient mutation analysis, and immunolocalization

    PMID:10051604

    Open questions at the time
    • Mechanism of membrane association unclear
    • Substrates (PMPs) bound by PEX19 not yet defined
    • Role of farnesylation not functionally dissected
  2. 2000 High

    Demonstration that PEX19 binds a broad spectrum of PMPs in the cytosol and that its loss causes PMP degradation or mitochondrial mistargeting established PEX19 as a cytosolic chaperone/receptor rather than a simple membrane component.

    Evidence Co-immunoprecipitation, subcellular fractionation, nuclear mislocalization assay, and loss-of-function in PEX19-deficient cells

    PMID:10704444

    Open questions at the time
    • Nature of PMP targeting signals recognized by PEX19 unknown
    • Docking factor at the peroxisomal membrane unidentified
  3. 2003 High

    Showing that the PEX3–PEX19 interaction occurs predominantly at the peroxisomal membrane resolved where in the cell cargo handoff takes place, and domain mapping linked the PEX19 N-terminus to PEX3 binding.

    Evidence Quantitative FRET imaging in living cells with domain deletion analysis

    PMID:12924628

    Open questions at the time
    • Structural basis of PEX3–PEX19 interface not resolved
    • Cargo release mechanism unknown
  4. 2004 High

    Defining PEX19 as both chaperone and import receptor for class 1 PMPs, and establishing PEX3 as the membrane docking factor, completed the core PEX3–PEX19 import pathway model.

    Evidence In vitro binding/stabilization assays, heterologous targeting, dominant-negative/transient inhibition, complementation in PEX3- and PEX19-deficient cells

    PMID:14709540 PMID:15007061

    Open questions at the time
    • Structural details of PEX3–PEX19 docking unknown
    • Cargo release mechanism at the membrane unresolved
    • How PEX19 distinguishes class 1 from class 2 PMPs unclear
  5. 2005 High

    Mapping PEX19-binding sites on PMPs such as ALDP/PEX26 showed that these sites function as conserved targeting motifs, and luminal basic residues are critical for preventing mitochondrial mistargeting.

    Evidence Peptide array binding, mutagenesis, cross-species targeting assays in human fibroblasts and yeast

    PMID:15781447 PMID:16763195

    Open questions at the time
    • Structural basis of PMP signal recognition by PEX19 unresolved
    • How the same signals avoid mitochondrial targeting machinery not fully explained
  6. 2009 High

    The crystal structure of PEX14N in complex with a PEX19 motif revealed that PEX5 and PEX19 compete for the same site on PEX14, suggesting PEX19 plays a role in PEX14 membrane insertion and connecting the membrane and matrix import machineries.

    Evidence Crystal structure, NMR, mutagenesis, in vivo localization in yeast

    PMID:19197237

    Open questions at the time
    • Physiological consequence of PEX5/PEX19 competition at PEX14 not fully explored in mammalian cells
    • Whether PEX14 is a true cargo of PEX19 in vivo still debated
  7. 2010 High

    Crystal structures of the PEX3 cytosolic domain bound to PEX19 peptide revealed a hydrophobic groove on PEX3 engaging PEX19-Phe29, providing the atomic-level mechanism of receptor–docking factor recognition.

    Evidence X-ray crystallography, mutagenesis, binding affinity measurements

    PMID:20554521 PMID:22624858

    Open questions at the time
    • Full-length PEX19 structure in complex with PEX3 not available
    • How PEX3 binding triggers cargo release unresolved
  8. 2013 High

    Reconstitution of PEX19-dependent, TRC40-independent targeting of the tail-anchored protein PEX26 to peroxisomes demonstrated a complete alternative TA insertion pathway distinct from the ER GET pathway.

    Evidence Co-immunoprecipitation, siRNA knockdown, mutagenesis, in vivo targeting assays

    PMID:23460677

    Open questions at the time
    • Membrane insertion step not reconstituted in a cell-free system
    • Generality to other TA PMPs not fully tested
  9. 2017 High

    NMR structure of farnesylated PEX19 C-terminal domain showed that the farnesyl group is buried internally, allosterically creating hydrophobic pockets for PMP recognition—explaining why farnesylation enhances but is not absolutely required for PMP binding.

    Evidence NMR structure, mutagenesis, functional complementation in Zellweger patient fibroblasts

    PMID:28281558

    Open questions at the time
    • Structure of full-length farnesylated PEX19 bound to intact PMP cargo unavailable
    • Energetic contribution of farnesylation versus direct PMP contacts not quantitatively separated
  10. 2018 High

    Discovery that yeast Pex19 mediates targeting of mitochondrial tail-anchored proteins Fis1 and Gem1 expanded PEX19's role beyond peroxisomes to mitochondrial biogenesis.

    Evidence Yeast genetics (PEX19 deletion), in organello import assay, direct binding with recombinant proteins

    PMID:30033679

    Open questions at the time
    • Whether this mitochondrial targeting role is conserved in mammals not demonstrated
    • Mechanism distinguishing peroxisomal from mitochondrial delivery unknown
  11. 2022 Medium

    Separation-of-function analysis showed that farnesylated PEX19 specifically controls lipid droplet protein composition and neutral lipid metabolism through a peroxisome-independent mechanism, revealing a third organelle target for PEX19.

    Evidence Farnesylation mutant analysis, proteomics, lipidomics, rescue experiments in PEX19-deficient cells

    PMID:35557938

    Open questions at the time
    • Identity of lipid droplet targeting receptor (PEX3 equivalent) unknown
    • Structural basis of farnesylation-dependent LD specificity unresolved
    • Not independently replicated
  12. 2024 Medium

    Identification of PEX19 helix αd as a dual-function element that shields PMP TMDs from cytosolic chaperones and triggers PEX3-dependent cargo release resolved the long-standing question of how PEX19 couples cargo protection to destination-specific release.

    Evidence Biochemical analysis, mass spectrometry, mutagenesis, in vivo targeting assay

    PMID:38585659

    Open questions at the time
    • Structural visualization of αd–PEX3 interaction in the full complex not available
    • Generality of αd-mediated release to diverse PMP cargoes not tested
    • Single-lab finding
  13. 2025 Medium

    Epistasis analysis in yeast revealed a dynamic quality-control cycle in which Msp1 extracts both mistargeted and correctly localized Pex15, with Pex19–Pex3 mediating re-insertion, redefining PEX19's role as not just an import factor but a continuous maintenance chaperone.

    Evidence Yeast genetics with multiple deletion combinations and in vivo localization

    PMID:40344504

    Open questions at the time
    • Whether mammalian PEX19 participates in analogous quality-control cycles unknown
    • Msp1/ATAD1-PEX19 handoff mechanism not biochemically reconstituted
    • Single-lab study

Open questions

Synthesis pass · forward-looking unresolved questions
  • A full structural model of PEX19 bound simultaneously to a PMP cargo and PEX3, and the mechanism by which PMP transmembrane domains are inserted into the peroxisomal lipid bilayer, remain unresolved.
  • No structure of full-length farnesylated PEX19 in ternary complex with PEX3 and PMP cargo
  • Membrane insertion mechanism not reconstituted in vitro
  • Rules distinguishing peroxisomal, mitochondrial, and lipid droplet targeting by PEX19 undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0044183 protein folding chaperone 3 GO:0060090 molecular adaptor activity 3 GO:0008289 lipid binding 2
Localization
GO:0005829 cytosol 3 GO:0005777 peroxisome 2 GO:0005811 lipid droplet 1
Pathway
R-HSA-9609507 Protein localization 5 R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-1430728 Metabolism 2 R-HSA-168256 Immune System 1
Partners
FIS1GEM1PEX11PEX14PEX26PEX3RSAD2
Complex memberships
PEX3-PEX19 import complex

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 PEX19 binds a broad spectrum of peroxisomal membrane proteins (PMPs) in the cytoplasm, is predominantly cytosolic at steady state, and its mislocalization to the nucleus causes nuclear accumulation of newly synthesized PMPs; loss of PEX19 leads to degradation or mistargeting of PMPs to mitochondria, establishing PEX19 as required for peroxisome membrane synthesis. Co-immunoprecipitation, subcellular fractionation, mislocalization assay, loss-of-function in PEX19-deficient cells The Journal of cell biology High 10704444
1999 Human PEX19 encodes a 299-aa hydrophilic protein with a C-terminal CAAX farnesylation motif; farnesylated PEX19 is partly anchored in the peroxisomal membrane with its N-terminal region exposed to the cytosol; PEX19 is required for peroxisome membrane assembly at an early stage, before matrix protein import. Functional complementation of CHO mutant ZP119, mutation analysis in Zellweger patient, immunolocalization Proceedings of the National Academy of Sciences of the United States of America High 10051604
2004 PEX19 functions as both a cytosolic chaperone and an import receptor for newly synthesized class 1 PMPs: it binds and stabilizes PMPs in the cytosol, interacts with hydrophobic PMP targeting signals (mPTSs), and is essential for class 1 PMP targeting and import; class 2 mPTSs are PEX19-independent. In vitro binding assays, PMP stabilization assays, complementation in PEX19-deficient cells, RNAi knockdown The Journal of cell biology High 14709540
2004 PEX3 is the docking factor for PEX19 at the peroxisomal membrane: PEX3 is required for PEX19 docking at peroxisomes, interacts specifically with the N-terminal docking domain of PEX19 via a conserved motif, is sufficient to dock PEX19 at heterologous organelles, and its transient inhibition abrogates class 1 PMP import but not class 2 or matrix protein import. Co-immunoprecipitation, heterologous targeting assay, transient inhibition/dominant-negative, complementation in PEX3-deficient cells The Journal of cell biology High 15007061
2006 The tail-anchored peroxisomal membrane protein PEX26 contains two PEX19-binding sites in its C-terminal targeting signal: one overlapping with the transmembrane domain and one in the luminal domain; the luminal PEX19-binding site is essential for correct peroxisomal targeting and prevents mislocalization to mitochondria; PEX19 is required for PEX26 import. Deletion/mutation analysis, heterologous targeting assay, co-immunoprecipitation, PEX19 knockdown Journal of cell science High 16763195
2005 PEX19-binding sites on peroxisomal membrane proteins (including ALDP/adrenoleukodystrophy protein) serve as targeting motifs; the identified PEX19-binding site of ALDP is bound by both human and yeast PEX19 and is required for peroxisomal targeting in human fibroblasts and in yeast, demonstrating evolutionary conservation of PMP targeting signals. Peptide array binding, in vivo targeting assays in human fibroblasts and yeast, deletion mutagenesis The Journal of biological chemistry High 15781447
2009 The N-terminal domain of Pex14 (Pex14N) adopts a three-helical fold and binds both Pex5 and Pex19 competitively at the same surface but with opposite directionality; a conserved F/YFxxxF motif in PEX19 mediates this interaction; mutations of Pex14 residues in the binding region disrupt Pex5/Pex19 binding in vitro and impair Pex14 peroxisomal membrane localization in vivo. Crystal structure, NMR, mutagenesis, in vitro binding, in vivo localization assay The EMBO journal High 19197237
2010 Crystal structure of the cytosolic domain of PEX3 in complex with a PEX19-derived peptide reveals that PEX3 adopts a novel large helical bundle fold with a hydrophobic groove at its membrane-distal end that engages the PEX19 peptide with nanomolar affinity; phenylalanine 29 of PEX19 is critical for the PEX3-PEX19 interaction. X-ray crystallography, mutagenesis, binding affinity measurements The Journal of biological chemistry High 20554521
2003 The PEX3-PEX19 interaction occurs predominantly at the peroxisomal membrane in living cells; the PEX19-binding domain in the C-terminal half of PEX3 is required for peroxisomal localization; deletion of the PEX3 N-terminal targeting sequence or the PEX19-binding domain mislocalizes PEX3 and abolishes interaction with PEX19. FRET imaging (EYFP/ECFP fusion proteins), donor photobleaching, complementation in PEX3- and PEX19-deficient fibroblasts European journal of cell biology High 12924628
2013 PEX19 forms a cytosolic complex with the tail-anchored peroxisomal membrane protein PEX26 and translocates it directly to peroxisomes by interacting with PEX3; this pathway is TRC40-independent; basic amino acids in the luminal domain of PEX26 are essential for PEX19 binding and peroxisomal targeting. Co-immunoprecipitation, dominant-negative/siRNA knockdown, mutagenesis, in vivo targeting assay The Journal of cell biology High 23460677
2017 Farnesylation of PEX19 at its C-terminal CaaX motif allosterically reshapes the PEX19 C-terminal domain to form two hydrophobic pockets that recognize conserved aromatic/aliphatic side chains in PMPs; the farnesyl moiety is buried in an internal hydrophobic cavity inducing conformational changes; mutations abolishing farnesyl contacts or PMP recognition prevent cargo binding and cannot complement a ΔPEX19 phenotype in Zellweger patient fibroblasts. NMR structure of farnesylated PEX19 CTD, mutagenesis, in vivo complementation in patient fibroblasts Nature communications High 28281558
2012 Mutagenesis of the PEX19-binding region of PEX3 reduces PEX19 affinity and destabilizes PEX3; the PEX3-PEX19 complex is required for de novo formation of peroxisomes; a hydrophobic groove near the base of PEX3 is involved in PMP insertion into the membrane. Site-directed mutagenesis, in vitro binding assays, functional complementation in peroxisome-deficient cells Traffic (Copenhagen, Denmark) High 22624858
2002 PEX19 is farnesylated in vitro and in vivo at its C-terminal CAAX motif; two splice variants differ in biological activity: PEX19ΔE8 (lacking domain D3/CAAX) restores peroxisomal biogenesis in PEX19-deficient fibroblasts and interacts with PEX3, demonstrating that farnesylation is not absolutely essential; PEX19ΔE2 (lacking N-terminal domain D1) fails to restore biogenesis and cannot interact with PEX3 lacking its peroxisomal targeting region. In vitro farnesylation assay, co-immunoprecipitation, functional complementation in PEX19-deficient fibroblasts Biochemical and biophysical research communications Medium 11883941
2017 Deletion mapping in Pichia pastoris defines the minimum N-terminal (aa 1-150) and C-terminal (aa 89-300) regions of Pex19 required for peroxisome biogenesis; N-terminal deletions disrupt Pex3 binding while preserving Pex10 interaction; C-terminal deletions disrupt PMP (Pex10) binding while preserving Pex3 interaction; Pex25 overexpression can partially rescue Pex19 C-terminal truncation by enhancing Pex3 interaction. Deletion mutagenesis, co-immunoprecipitation, growth assay, yeast genetics The Journal of biological chemistry Medium 28526747
2018 In budding yeast, Pex19 acts as an import mediator for a subset of mitochondrial tail-anchored (TA) proteins (Fis1 and Gem1); deletion of PEX19 causes growth defects under respiratory conditions, altered mitochondrial morphology, reduced steady-state levels of Fis1 and Gem1, and hampered in organello import of these TA proteins; recombinant Pex19 directly binds Fis1 and Gem1. Yeast genetics (PEX19 deletion), in organello import assay, direct binding with recombinant proteins, steady-state level analysis Traffic (Copenhagen, Denmark) High 30033679
2014 PEX19 is an intrinsically disordered protein; upon interaction with PEX3, three regions of PEX19 become protected from hydrogen exchange (N-terminus, a middle stretch F64-L74, and C-terminus), while PEX3 becomes more protected in its binding groove; the N-terminus of PEX19 initiates binding to PEX3, followed by subtle conformational changes in PEX3 that allow higher-affinity engagement via folding of a short helix in PEX19. Hydrogen exchange mass spectrometry PloS one Medium 25062251
2022 Pex11 contains one Pex19-binding site (Pex19-BS) required for Pex19-mediated membrane insertion but non-essential for peroxisomal trafficking; Pex19 acts as a chaperone by binding Pex19-BS in Pex11 and preventing spontaneous Pex11 oligomerization and aggregation; Pex11 also has a second, Pex19-independent mPTS for peroxisomal trafficking. Mutagenesis, co-immunoprecipitation, in vivo targeting assay, aggregation assay in Pichia pastoris Cells Medium 35011719
2022 Non-farnesylated PEX19 is sufficient to restore peroxisomal metabolic activity, while farnesylated PEX19 specifically controls lipid droplet (LD) protein composition and neutral lipid metabolism through a peroxisome-independent mechanism; in the absence of PEX19-dependent LD proteome, cells accumulate excess triacylglycerols and fail to deplete neutral lipid stores. Farnesylation mutant analysis, systems-level proteomics, lipid quantification, rescue experiments in PEX19-deficient cells Frontiers in cell and developmental biology Medium 35557938
2024 A conserved PEX19 helix (αd) prevents improper exposure of the PEX26 transmembrane domain (TMD) to cytosolic chaperones, and the αd helix also interacts with the cytosolic domain of the PEX3 receptor to trigger PEX26 release at the correct destination membrane; the PEX3-G138E mutant abolishes this secondary interaction, preventing PEX3-induced PEX26 release from PEX19. Biochemical analysis, mass spectrometry, mutagenesis, in vivo targeting assay iScience Medium 38585659
2021 Viperin (an interferon-stimulated gene product) binds PEX19 as a physical interaction partner; viperin colocalizes with peroxisomal proteins and its augmentation of RIG-I-like receptor (RLR) signaling requires PEX19 expression; knockdown of PEX19 abolishes viperin-mediated augmentation of innate antiviral signaling. Proteomics-based screening, co-immunoprecipitation, colocalization, RNAi knockdown with functional readout (IFN-β induction) Life science alliance Medium 34108265
2025 In yeast, newly synthesized Pex15 is targeted to peroxisomes primarily via the Pex19-Pex3-dependent pathway; mistargeted Pex15 on mitochondria is extracted by the AAA-ATPase Msp1 and transferred to the ER for degradation or re-routed to peroxisomes via the Pex19-Pex3 pathway; even correctly localized peroxisomal Pex15 is extracted by peroxisomal Msp1 but returned to peroxisomes via Pex19-Pex3, revealing a dynamic quality-control cycle. Yeast genetics (deletion mutants), in vivo localization, epistasis analysis The FEBS journal Medium 40344504
2017 In Drosophila Pex19 mutants, loss of peroxisomes leads to HNF4-induced lipotoxicity: hyperactive HNF4 signaling upregulates lipase 3 and mitochondrial β-oxidation enzymes, resulting in enhanced lipolysis, elevated free fatty acids, and mitochondrial damage; increased acid lipase expression and free fatty acid accumulation are also observed in PEX19-deficient human patient fibroblasts. Drosophila Pex19 mutant analysis, genetic epistasis (Hnf4), patient fibroblast biochemical analysis Molecular biology of the cell Medium 29282281

Source papers

Stage 0 corpus · 53 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. The Journal of cell biology 257 10704444
2004 PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins. The Journal of cell biology 205 14709540
2004 PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins. The Journal of cell biology 191 15007061
1999 Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly. Proceedings of the National Academy of Sciences of the United States of America 190 10051604
1998 pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast. The EMBO journal 111 9427748
2006 Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites. Journal of cell science 104 16763195
2013 Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway. The Journal of cell biology 80 23460677
2009 Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19. The EMBO journal 73 19197237
2005 Function of the PEX19-binding site of human adrenoleukodystrophy protein as targeting motif in man and yeast. PMP targeting is evolutionarily conserved. The Journal of biological chemistry 63 15781447
2019 The peroxisome biogenesis factors Pex3 and Pex19: multitasking proteins with disputed functions. FEBS letters 52 30776093
2010 Insights into peroxisome function from the structure of PEX3 in complex with a soluble fragment of PEX19. The Journal of biological chemistry 48 20554521
2017 Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants. Molecular biology of the cell 45 29282281
2017 Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19. Nature communications 42 28281558
2018 Pex19 is involved in importing dually targeted tail-anchored proteins to both mitochondria and peroxisomes. Traffic (Copenhagen, Denmark) 40 30033679
2012 The role of conserved PEX3 regions in PEX19-binding and peroxisome biogenesis. Traffic (Copenhagen, Denmark) 38 22624858
2003 The interaction between human PEX3 and PEX19 characterized by fluorescence resonance energy transfer (FRET) analysis. European journal of cell biology 38 12924628
2005 Identification of trypanosomatid PEX19: functional characterization reveals impact on cell growth and glycosome size and number. Molecular and biochemical parasitology 35 15907560
2007 Conservation of PEX19-binding motifs required for protein targeting to mammalian peroxisomal and trypanosome glycosomal membranes. Eukaryotic cell 26 17586720
1994 Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1. Gene 25 8076834
2002 Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly. Biochemical and biophysical research communications 22 11883941
2006 Arabidopsis PEX19 is a dimeric protein that binds the peroxin PEX10. Molecular membrane biology 21 16923726
2000 PMP1 18-38, a yeast plasma membrane protein fragment, binds phosphatidylserine from bilayer mixtures with phosphatidylcholine: a (2)H-NMR study. Biophysical journal 21 11053135
2017 Functional regions of the peroxin Pex19 necessary for peroxisome biogenesis. The Journal of biological chemistry 18 28526747
2017 New insights into the distribution, protein abundance and subcellular localisation of the endogenous peroxisomal biogenesis proteins PEX3 and PEX19 in different organs and cell types of the adult mouse. PloS one 18 28817674
1998 1H- and 2H-NMR studies of a fragment of PMP1, a regulatory subunit associated with the yeast plasma membrane H(+)-ATPase. Conformational properties and lipid-peptide interactions. Biochimie 16 9782385
2016 The Early-Acting Peroxin PEX19 Is Redundantly Encoded, Farnesylated, and Essential for Viability in Arabidopsis thaliana. PloS one 14 26824478
1998 Genomic organization of the 70-kDa peroxisomal membrane protein gene (PXMP1). Genomics 14 9521874
2018 Intracellular communication between lipid droplets and peroxisomes: the Janus face of PEX19. Biological chemistry 13 29500918
2010 A mutation in PEX19 causes a severe clinical phenotype in a patient with peroxisomal biogenesis disorder. American journal of medical genetics. Part A 11 20683989
2021 A Small Molecule Inhibitor of Pex3-Pex19 Interaction Disrupts Glycosome Biogenesis and Causes Lethality in Trypanosoma brucei. Frontiers in cell and developmental biology 9 34350186
2022 Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif. Viruses 8 35215846
2022 PEX19 Coordinates Neutral Lipid Storage in Cells in a Peroxisome-Independent Fashion. Frontiers in cell and developmental biology 8 35557938
2014 Association between the intrinsically disordered protein PEX19 and PEX3. PloS one 8 25062251
2022 Recognition and Chaperoning by Pex19, Followed by Trafficking and Membrane Insertion of the Peroxisome Proliferation Protein, Pex11. Cells 7 35011719
2021 Viperin interacts with PEX19 to mediate peroxisomal augmentation of the innate antiviral response. Life science alliance 7 34108265
2022 Crystal structure of the OrfX1-OrfX3 complex from the PMP1 neurotoxin gene cluster. FEBS letters 6 36403098
2021 Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3-PEX19 Interaction. Frontiers in cell and developmental biology 6 34988071
2010 In vitro assay of the interaction between Rnc1 protein and Pmp1 mRNA by affinity capillary electrophoresis with a carboxylated capillary. Journal of pharmaceutical and biomedical analysis 6 20692117
1998 Genomic organization and chromosomal localization of the human peroxisomal membrane protein-1-like protein (PXMP1-L) gene encoding a peroxisomal ABC transporter. FEBS letters 6 9599016
2022 Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei. Journal of personalized medicine 5 35207746
2008 Complete sequence of plasmid pMP1 from the marine environmental Vibrio vulnificus and location of its replication origin. Marine biotechnology (New York, N.Y.) 5 19009320
1998 The mouse gene encoding the peroxisomal membrane protein 1-like protein (PXMP1-L): cDNA cloning, genomic organization and comparative expression studies. FEBS letters 5 9738957
2025 Msp1 and Pex19-Pex3 cooperate to achieve correct localization of Pex15 to peroxisomes. The FEBS journal 4 40344504
2024 A dual role of the conserved PEX19 helix in safeguarding peroxisomal membrane proteins. iScience 4 38585659
2011 Membrane interface composition drives the structure and the tilt of the single transmembrane helix protein PMP1: MD studies. Biophysical journal 4 21463579
2024 The M2 Protein of the Influenza A Virus Interacts with PEX19 to Facilitate Virus Replication by Disrupting the Function of Peroxisome. Viruses 3 39205283
2025 Zellweger syndrome; identification of mutations in PEX19 and PEX26 gene in Saudi families. Annals of medicine 2 39757991
2018 PmpI antibody reduces the inhibitory effect of Vp1 on Chlamydia trachomatis infectivity. Canadian journal of microbiology 2 29510061
2017 Peroxisome biogenesis: a novel inducible PEX19 splicing variant is involved in early stages of peroxisome proliferation. Journal of biochemistry 1 28391327
2026 Colab-PEX19BS: An Automated Google Colab Notebook-Based Tool for Detecting PEX19-Binding Sites. Methods in molecular biology (Clifton, N.J.) 0 41627762
2026 PEX19 restricts porcine deltacoronavirus replication through farnesylation-dependent and -independent mechanisms. Journal of virology 0 41874194
2024 Simultaneous PCR detection of Paenibacillus larvae targeting insertion sequence IS256 and Melissococcus plutonius targeting pMP1 plasmid from hive specimens. Folia microbiologica 0 38180723
2023 Correction: Noguchi et al. Establishment and Characterization of NCC-PMP1-C1: A Novel Patient-Derived Cell Line of Metastatic Pseudomyxoma Peritonei. J. Pers. Med. 2022, 12, 258. Journal of personalized medicine 0 37763192