Affinage

PCNT

Pericentrin · UniProt O95613

Length
3336 aa
Mass
378.0 kDa
Annotated
2026-04-29
100 papers in source corpus 9 papers cited in narrative 9 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PCNT (pericentrin) is a large coiled-coil scaffold protein of the pericentriolar material (PCM) that organizes microtubule nucleation, controls centriole engagement and duplication, and regulates mitotic spindle assembly. PCNT mRNA is delivered co-translationally to centrosomes by cytoplasmic dynein during early mitosis, where PCNT assembles a PCM matrix together with CDK5RAP2 that recruits γ-tubulin complexes and supports both centriole-dependent and centriole-independent spindle assembly (PMID:29708497, PMID:33170211). During mitotic exit, PLK1 phosphorylates PCNT to prime it for separase-mediated cleavage, which dissolves the PCM matrix, releases CEP215 from the core PCM, and licenses centriole disengagement and subsequent duplication; non-cleavable PCNT mutants block centriole separation, while PCNT deletion causes premature centriole separation and amplification (PMID:26647647, PMID:25503564, PMID:30814333). Biallelic loss-of-function mutations in PCNT cause microcephalic osteodysplastic primordial dwarfism type II (MOPD II), characterized by disorganized mitotic spindles and chromosome missegregation (PMID:18174396).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1996 Medium

    Mapping PCNT to human chromosome 21q and identifying it as a conserved centrosomal matrix component established the gene's identity and its association with microtubule organization.

    Evidence Exon trapping, PCR, Southern blot, and FISH on human genomic DNA

    PMID:8812505

    Open questions at the time
    • No functional perturbation in human cells
    • Protein domain architecture not yet resolved
    • No disease link established
  2. 2008 High

    Demonstrating that biallelic PCNT loss-of-function mutations cause MOPD II with disorganized spindles and chromosome missegregation established PCNT as essential for mitotic spindle integrity in humans.

    Evidence Genetic linkage analysis and mitotic spindle imaging across 25 patient-derived cell lines

    PMID:18174396

    Open questions at the time
    • Molecular mechanism of spindle disorganization not defined
    • Downstream targets mediating the phenotype unknown
  3. 2013 Medium

    Identifying PCNT as a centrosomal scaffold that tethers Chk1 revealed a checkpoint-coupling function: PCNT depletion deregulates centrosomal cyclin B–CDK1 activation and promotes supernumerary centrosomes.

    Evidence Co-immunoprecipitation of Che-1/PCNT/Chk1, siRNA knockdown, centrosome counting

    PMID:23798705

    Open questions at the time
    • Chk1–PCNT interaction stoichiometry and binding site not mapped
    • Contribution of this checkpoint axis to the MOPD II phenotype untested
    • Single lab study without independent replication
  4. 2014 High

    Showing that separase cleaves PCNT during mitotic exit to release CEP215 from the core PCM and license centriole disengagement defined the proteolytic event that dissolves the PCM and couples mitotic exit to the centriole duplication cycle.

    Evidence Reciprocal co-immunoprecipitation, mass spectrometry, RNAi, live-cell imaging in human cells

    PMID:25503564

    Open questions at the time
    • Structural basis of the PCNT–CEP215–Cep68 complex not determined
    • Precise separase cleavage site on PCNT debated
  5. 2015 High

    Establishing that PLK1 phosphorylation of PCNT primes it for separase cleavage resolved the upstream kinase signal: phospho-resistant PCNT is non-cleavable, while phospho-mimetic PCNT rescues cleavage even under PLK1 inhibition.

    Evidence Phospho-resistant and phospho-mimetic PCNT mutants, PLK1 inhibitor treatment, centriole separation assay

    PMID:26647647

    Open questions at the time
    • Whether additional kinases can substitute for PLK1 is untested
    • How phosphorylation changes separase recognition structurally is unknown
  6. 2018 High

    Discovering that PCNT mRNA is delivered co-translationally to centrosomes by dynein during early mitosis explained how the large PCNT protein accumulates rapidly at centrosomes for PCM maturation.

    Evidence Single-molecule mRNA FISH, puromycin-mediated polysome disruption, dynein inhibition in human cells

    PMID:29708497

    Open questions at the time
    • Cis-regulatory elements in PCNT mRNA directing localization not identified
    • Whether other PCM transcripts use the same pathway is unknown
  7. 2019 High

    PCNT deletion and non-cleavable mutant experiments demonstrated that PCNT tethers centrioles within the spindle pole during mitosis and that its controlled cleavage is required for daughter-to-mother centriole conversion at mitotic exit.

    Evidence PCNT KO, non-cleavable mutant, TEV protease-induced acute cleavage, centrosome immunofluorescence

    PMID:30814333

    Open questions at the time
    • Molecular contacts between PCNT and centriolar wall proteins not identified
    • How centriole conversion is sensed downstream is unclear
  8. 2020 High

    Demonstrating that the PCNT–CDK5RAP2 matrix can self-organize independently of centrioles to recruit γ-tubulin and nucleate microtubules established PCNT as a core structural organizer of a centriole-independent spindle assembly pathway.

    Evidence PLK4 inhibition for centriole depletion combined with PCNT/CDK5RAP2 RNAi/KO, γ-tubulin recruitment assays

    PMID:33170211

    Open questions at the time
    • Biophysical properties (phase separation, stoichiometry) of the PCNT–CDK5RAP2 matrix not characterized
    • Whether this pathway is active in vivo during normal mitosis is uncertain
  9. 2021 Medium

    Triple knockout of TP53, PCNT, and CEP215 showed that PCNT deletion contributes to M-phase centriole amplification, with supernumerary centrioles lacking full compositional maturity, clarifying epistatic relationships among PCM components in centriole copy control.

    Evidence CRISPR triple KO, centriole marker immunofluorescence throughout cell cycle

    PMID:34233584

    Open questions at the time
    • Relative contributions of each gene to the amplification phenotype not fully deconvolved
    • Whether these immature centrioles are functional MTOCs is unknown
    • Single lab study

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis of the PCNT–CDK5RAP2 PCM matrix, the biophysical properties governing its assembly and dissolution, and the complete set of cis-elements directing PCNT mRNA co-translational targeting remain unresolved.
  • No high-resolution structure of full-length PCNT or PCNT within the PCM
  • Phase separation versus classical scaffold assembly not distinguished
  • mRNA localization signals in PCNT transcript not mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 5
Localization
GO:0005815 microtubule organizing center 8
Pathway
R-HSA-1640170 Cell Cycle 6 R-HSA-1852241 Organelle biogenesis and maintenance 5
Partners
CDK5RAP2CEP68CHEK1DYNC1H1ESPL1PLK1
Complex memberships
PCM matrix (PCNT–CDK5RAP2–Cep68)

Evidence

Reading pass · 9 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 Biallelic loss-of-function mutations in PCNT cause disorganized mitotic spindles and missegregation of chromosomes, establishing PCNT as essential for mitotic spindle organization in human cells. Genetic linkage analysis, patient cell biology (loss-of-function), mitotic spindle imaging Science High 18174396
2014 PCNT forms a complex with Cep68 and CEP215 (CDK5RAP2) at the pericentriolar material; separase-mediated cleavage of PCNT during mitotic exit mediates CEP215 removal from the core PCM to inhibit centriole disengagement and duplication, while Cep68 degradation removes CEP215 from peripheral PCM to prevent premature centriole separation. Co-immunoprecipitation, mass spectrometry, RNAi knockdown, live-cell imaging, fractionation Nature Cell Biology High 25503564
2015 PLK1 phosphorylates PCNT as a priming step required for separase-mediated cleavage of PCNT during mitotic exit; phospho-resistant PCNT mutants are not cleaved by separase and block centriole separation, while phospho-mimetic mutants rescue centriole separation even when PLK1 is inhibited. Mutagenesis (phospho-resistant and phospho-mimetic mutants), PLK1 inhibitor treatment, centriole separation assay, live-cell imaging Nature Communications High 26647647
2019 PCNT is critical for maintaining centriole association within the spindle pole during mitosis; PCNT deletion causes premature centriole separation and centriole amplification during mitosis. Specific cleavage of PCNT is required during mitotic exit to allow daughter-to-mother centriole conversion; a non-cleavable PCNT mutant prevents centriole separation and conversion. PCNT knockout/deletion, non-cleavable mutant expression, TEV protease-induced cleavage, centrosome immunofluorescence, cell cycle staging Journal of Cell Science High 30814333
2018 PCNT mRNA is delivered co-translationally to centrosomes during early mitosis by cytoplasmic dynein; centrosomal enrichment of PCNT mRNA, its translation near centrosomes, and requirement of intact polysomes for PCNT mRNA localization were demonstrated, establishing co-translational targeting as the mechanism for timely centrosomal PCNT enrichment during centrosome maturation. Single-molecule FISH for mRNA localization, polysome disruption (puromycin treatment), live-cell imaging, dynein inhibition eLife High 29708497
2020 The PCM matrix assembled from PCNT and CDK5RAP2 is essential for centriole-independent mitotic spindle assembly; when centrioles are absent, acentriolar spindle assembly requires PCNT-CDK5RAP2-dependent matrix assembly and CDK5RAP2's ability to recruit γ-tubulin complexes. The PCM matrix can self-organize independently of centrioles to generate microtubules. Centriole depletion (PLK4 inhibition), PCNT and CDK5RAP2 depletion by RNAi/knockout, γ-tubulin recruitment assays, spindle assembly imaging Journal of Cell Biology High 33170211
2013 PCNT serves as a scaffold at centrosomes that mediates Chk1 localization; depletion of Che-1 abolishes Chk1 binding to PCNT and its centrosomal localization, deregulating centrosomal cyclin B-CDK1 activation and advancing mitotic entry. PCNT depletion results in supernumerary centrosomes, multinucleated cells, and multipolar spindles. Co-immunoprecipitation (Che-1/PCNT/Chk1), siRNA knockdown, centrosome immunofluorescence, cell cycle analysis Journal of Biological Chemistry Medium 23798705
1996 The human PCNT gene was mapped to chromosome 21q (between PFKL and 21qter), and the encoded pericentrin protein was identified as a conserved component of the filamentous centrosomal matrix involved in establishment of the organized microtubule array. Exon trapping, PCR amplification, Southern blot, FISH Genomics Medium 8812505
2021 Triple knockout of TP53, PCNT, and CEP215 promotes centriole amplification during M phase; PCNT deletion contributes to precocious centriole separation, and supernumerary centrioles generated in M phase lack full compositional integrity (missing CEP135, CEP192, CEP295, CEP152). Triple KO cell generation (CRISPR), centriole marker immunofluorescence throughout cell cycle, centrosome counting Cell Cycle Medium 34233584

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes & development 552 10733526
2005 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal. Molecular and cellular biology 344 15899874
2008 Mutations in the pericentrin (PCNT) gene cause primordial dwarfism. Science (New York, N.Y.) 309 18174396
2001 D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p. Genes & development 152 11562348
2005 Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property. Molecular and cellular biology 135 15923616
2001 Formation of PCDF, PCDD, PCB, and PCN in de novo synthesis from PAH: mechanistic aspects and correlation to fluidized bed incinerators. Chemosphere 126 11513122
2007 Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint. PloS one 115 17406666
2011 BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. Journal of cell science 90 22193957
2009 Molecular analysis of pericentrin gene (PCNT) in a series of 24 Seckel/microcephalic osteodysplastic primordial dwarfism type II (MOPD II) families. Journal of medical genetics 86 19643772
2018 Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates. eLife 82 29708497
2014 Reducing NO and N₂O emission during aerobic denitrification by newly isolated Pseudomonas stutzeri PCN-1. Bioresource technology 79 24747385
2008 The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C). The Journal of biological chemistry 79 18556659
2002 Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway. Proceedings of the National Academy of Sciences of the United States of America 77 11842186
2023 Self-Driven Electron Transfer Biomimetic Enzymatic Catalysis of Bismuth-Doped PCN-222 MOF for Rapid Therapy of Bacteria-Infected Wounds. ACS nano 76 36622022
2014 Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nature cell biology 70 25503564
2017 Effect of sulfamethoxazole on aerobic denitrification by strain Pseudomonas stutzeri PCN-1. Bioresource technology 63 28376383
2006 KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome. The Journal of biological chemistry 62 17158872
2021 Understanding disorder and linker deficiency in porphyrinic zirconium-based metal-organic frameworks by resolving the Zr8O6 cluster conundrum in PCN-221. Nature communications 58 34035286
2015 Interaction of Cr(VI) reduction and denitrification by strain Pseudomonas aeruginosa PCN-2 under aerobic conditions. Bioresource technology 57 25795449
2003 Xkid is degraded in a D-box, KEN-box, and A-box-independent pathway. Molecular and cellular biology 57 12773557
2015 PLK1 regulation of PCNT cleavage ensures fidelity of centriole separation during mitotic exit. Nature communications 55 26647647
1989 Human fetal and adult liver metabolism of ethylmorphine. Relation to immunodetected cytochrome P-450 PCN and interactions with important fetal corticosteroids. Biochemical pharmacology 54 2818616
2010 Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. Journal of cell science 47 20053638
2023 A novel CRISPR/Cas14a-based electrochemical biosensor for ultrasensitive detection of Burkholderia pseudomallei with PtPd@PCN-224 nanoenzymes for signal amplification. Biosensors & bioelectronics 46 36701949
2006 Ken & barbie selectively regulates the expression of a subset of Jak/STAT pathway target genes. Current biology : CB 41 16401426
2016 Effects of heavy metals on aerobic denitrification by strain Pseudomonas stutzeri PCN-1. Applied microbiology and biotechnology 39 27853857
2012 GPS-ARM: computational analysis of the APC/C recognition motif by predicting D-boxes and KEN-boxes. PloS one 39 22479614
2011 Mechanism of action of the suppression of influenza virus replication by Ko-Ken Tang through inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway and viral RNP nuclear export. Journal of ethnopharmacology 38 21232589
2021 Single-dose HPV vaccination efficacy among adolescent girls and young women in Kenya (the KEN SHE Study): study protocol for a randomized controlled trial. Trials 37 34579786
2020 Centriole-independent mitotic spindle assembly relies on the PCNT-CDK5RAP2 pericentriolar matrix. The Journal of cell biology 37 33170211
2008 Unique D box and KEN box sequences limit ubiquitination of Acm1 and promote pseudosubstrate inhibition of the anaphase-promoting complex. The Journal of biological chemistry 34 18596038
2011 The smallest teeth in the world are caused by mutations in the PCNT gene. American journal of medical genetics. Part A 33 21567919
2009 Majewski osteodysplastic primordial dwarfism type II (MOPD II) syndrome previously diagnosed as Seckel syndrome: report of a novel mutation of the PCNT gene. American journal of medical genetics. Part A 31 19839044
1989 Evidence for a PCN-P450 enzyme in chickens and comparison of its development with that of other phenobarbital-inducible forms. Molecular pharmacology 30 2725470
2016 Potential application of aerobic denitrifying bacterium Pseudomonas aeruginosa PCN-2 in nitrogen oxides (NOx) removal from flue gas. Journal of hazardous materials 29 27469045
2003 Drosophila securin destruction involves a D-box and a KEN-box and promotes anaphase in parallel with Cyclin A degradation. Journal of cell science 29 12724352
2001 The KEN box regulates Clb2 proteolysis in G1 and at the metaphase-to-anaphase transition. Current biology : CB 29 11719221
2017 Effects of ZnO nanoparticles on aerobic denitrification by strain Pseudomonas stutzeri PCN-1. Bioresource technology 28 28500885
2012 Repeated dose toxicity and relative potency of 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) compared to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for induction of CYP1A1, CYP1A2 and thymic atrophy in female Harlan Sprague-Dawley rats. Toxicology 28 22813907
2008 Discovery of candidate KEN-box motifs using cell cycle keyword enrichment combined with native disorder prediction and motif conservation. Bioinformatics (Oxford, England) 28 18184688
2002 Expression of rat Multidrug Resistance Protein 2 (Mrp2) in male and female rats during normal and pregnenolone-16alpha-carbonitrile (PCN)-induced postnatal ontogeny. Toxicology 27 12167307
2022 A New Paradigm in Pincer Iridium Chemistry: PCN Complexes for (De)Hydrogenation Catalysis and Beyond. Accounts of chemical research 26 35852837
2004 Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB). Toxicological sciences : an official journal of the Society of Toxicology 25 15201439
1985 Age- and sex-dependent induction of liver microsomal benzo[a]pyrene hydroxylase activity in rats treated with pregnenolone-16 alpha-carbonitrile (PCN). Carcinogenesis 25 3986963
2019 PCNT is critical for the association and conversion of centrioles to centrosomes during mitosis. Journal of cell science 23 30814333
2015 Phenazine-1-carboxamide (PCN) from Pseudomonas sp. strain PUP6 selectively induced apoptosis in lung (A549) and breast (MDA MB-231) cancer cells by inhibition of antiapoptotic Bcl-2 family proteins. Apoptosis : an international journal on programmed cell death 23 25820140
2012 The Drosophila BCL6 homolog Ken and Barbie promotes somatic stem cell self-renewal in the testis niche. Developmental biology 23 22580161
2018 PCNT point mutations and familial intracranial aneurysms. Neurology 20 30413633
2009 Positive association of the pericentrin (PCNT) gene with major depressive disorder in the Japanese population. Journal of psychiatry & neuroscience : JPN 20 19448849
2003 The ken and barbie gene encoding a putative transcription factor with a BTB domain and three zinc finger motifs functions in terminalia development of Drosophila. Archives of insect biochemistry and physiology 20 14518006
1988 Monoclonal antibody directed detection of cytochrome P-450 (PCN) in human fetal liver. Biochemical pharmacology 20 3264502
2021 Insights into the Interaction between Immobilized Biocatalysts and Metal-Organic Frameworks: A Case Study of PCN-333. JACS Au 19 34977888
2012 The beneficial effects of Kampo medicine Dai-ken-chu-to after hepatic resection: a prospective randomized control study. Hepato-gastroenterology 19 23435143
2024 Highly sensitive and selective demethylase FTO detection using a DNAzyme-mediated CRISPR/Cas12a signal cascade amplification electrochemiluminescence biosensor with C-CN/PCNV heterojunction as emitter. Biosensors & bioelectronics 18 38599073
2015 Identification of two novel critical mutations in PCNT gene resulting in microcephalic osteodysplastic primordial dwarfism type II associated with multiple intracranial aneurysms. Metabolic brain disease 18 26231886
2013 Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization. The Journal of biological chemistry 16 23798705
2024 Sustainable Gold Nanoparticle (Au-NP) Growth within Interspaces of Porphyrinic Zirconium-Based Metal-Organic Frameworks: Green Synthesis of PCN-224/Au-NPs and Its Anticancer Effect on Colorectal Cancer Cells Assay. ACS applied materials & interfaces 12 38194287
2018 Matrimid-JUC-62 and Matrimid-PCN-250 mixed matrix membranes displaying light-responsive gas separation and beneficial ageing characteristics for CO2/N2 separation. Scientific reports 12 29440732
2013 The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART. Mobile DNA 12 23822164
2024 A Zn-modified PCN-224 fluorescent nanoprobe for selective and sensitive turn-on detection of glutathione. Talanta 11 38199125
2024 Strong cathode electroluminescence biosensor based on CeO2 functionalized PCN-222@Ag NPs for sensitive detection of p-Tau-181 protein. Journal of colloid and interface science 11 38520931
2023 Reprogramming of the tumor microenvironment using a PCN-224@IrNCs/D-Arg nanoplatform for the synergistic PDT, NO, and radiosensitization therapy of breast cancer and improving anti-tumor immunity. Nanoscale 11 37318099
2016 Differences in the action of lower and higher chlorinated polychlorinated naphthalene (PCN) congeners on estrogen dependent breast cancer cell line viability and apoptosis, and its correlation with Ahr and CYP1A1 expression. Toxicology 11 27501765
2025 Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation. Journal of experimental & clinical cancer research : CR 10 40382627
2023 Pharmacological profiles and anti-inflammatory activity of pCN-diEPP and mCN-diEPP, new alpha9alpha10 nicotinic receptor ligands. Neuropharmacology 10 37758018
2022 PCN-Miner: an open-source extensible tool for the analysis of Protein Contact Networks. Bioinformatics (Oxford, England) 10 35799364
2021 Disposable biosensor based on novel ternary Ru-PEI@PCN-333(Al) self-enhanced electrochemiluminescence system for on-site determination of caspase-3 activity. Talanta 10 34861485
2021 PCN-224 Nanoparticle/Polyacrylonitrile Nanofiber Membrane for Light-Driven Bacterial Inactivation. Nanomaterials (Basel, Switzerland) 10 34947511
2016 Identification of Candidate Target Cyp Genes for microRNAs Whose Expression Is Altered by PCN and TCPOBOP, Representative Ligands of PXR and CAR. Biological & pharmaceutical bulletin 10 27237601
2015 Reduction of PCN biosynthesis by NO in Pseudomonas aeruginosa. Redox biology 10 26874276
2023 The miR-184-3p promotes rice black-streaked dwarf virus infection by suppressing Ken in Laodelphax striatellus (Fallén). Pest management science 9 38050810
2022 Highly water-dispersible PCN nanosheets as light-controlled lysosome self-promoting escape type non-cationic gene carriers for tumor therapy. Journal of materials chemistry. B 9 35775960
2021 Modifier Genes in Microcephaly: A Report on WDR62, CEP63, RAD50 and PCNT Variants Exacerbating Disease Caused by Biallelic Mutations of ASPM and CENPJ. Genes 9 34068194
2020 Cellular evaluation of the metal-organic framework PCN-224 associated with inflammation and autophagy. Toxicology in vitro : an international journal published in association with BIBRA 9 33058999
2018 Cell cycle accumulation of the proliferating cell nuclear antigen PCN-1 transitions from continuous in the adult germline to intermittent in the early embryo of C. elegans. BMC developmental biology 9 29848313
2014 A new mutation of the PCNT gene in a Colombian patient with microcephalic osteodysplastic primordial dwarfism type II: a case report. Journal of medical case reports 9 24928221
2009 Association study between the pericentrin (PCNT) gene and schizophrenia. Neuromolecular medicine 9 19937158
1998 A transcription unit at the ken and barbie gene locus encodes a novel Drosophila zinc finger protein. Mechanisms of development 9 10349629
2022 Insight into sulfamethoxazole effects on aerobic denitrification by strain Pseudomonas aeruginosa PCN-2: From simultaneous degradation performance to transcriptome analysis. Chemosphere 8 36493888
2022 Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033). BMC genomics 7 35854219
2006 JAK/STAT signalling: STAT cannot play with Ken and Barbie. Current biology : CB 7 16461274
1996 Localization of a human homolog of the mouse pericentrin gene (PCNT) to chromosome 21qter. Genomics 7 8812505
2024 A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins. Nature communications 6 38509117
2024 Metal-Organic Framework PCN-224 Combined Cobalt Oxide Nanoparticles for Hypoxia Relief and Synergistic Photodynamic/Chemodynamic Therapy. Chemistry (Weinheim an der Bergstrasse, Germany) 6 38606488
2020 A Novel PCNT Frame Shift Variant (c.7511delA) Causing Osteodysplastic Primordial Dwarfism of Majewski Type 2 (MOPD II). Frontiers in pediatrics 6 32671003
2021 Triple deletion of TP53, PCNT, and CEP215 promotes centriole amplification in the M phase. Cell cycle (Georgetown, Tex.) 5 34233584
2021 RAB33B and PCNT variants in two Pakistani families with skeletal dysplasia and short stature. BMC musculoskeletal disorders 5 34284742
2021 A novel homozygous mutation of the PCNT gene in a Chinese patient with microcephalic osteodysplastic primordial dwarfism type II. Molecular genetics & genomic medicine 5 34331829
2020 Novel PCNT variants in MOPDII with attenuated growth restriction and pachygyria. Clinical genetics 5 32557621
2019 Identification of a novel PCNT founder pathogenic variant in the Israeli Druze population. European journal of medical genetics 5 30922925
2019 Epigenetic Memory Is Involved in the Persistent Alterations of Drug-Processing Genes in Adult Mice Due to PCN-Activated PXR During Early Life. Toxicological sciences : an official journal of the Society of Toxicology 5 31388680
2025 A split-type photoelectrochemical sensor based on In2S3/PCN-224 Z-scheme heterojunction for ultrasensitive detection of ampicillin. Mikrochimica acta 4 39934406
2023 Delivery of Immobilized IFN-γ With PCN-333 and Its Effect on Human Mesenchymal Stem Cells. ACS biomaterials science & engineering 4 36598843
2023 Exploring the role of sandwich-type polyoxometalates in {K10(PW9O34)2M4(H2O)2}@PCN-222 (M = Mn, Ni, Zn) for electroreduction of CO2 to CO. Dalton transactions (Cambridge, England : 2003) 4 37470104
2023 "Gold-plated" PCN-222(Fe) and superconductive carbon black-based sandwich-type immunosensor for detecting CYFRA21-1. Journal of materials chemistry. B 4 37578169
2022 Long-term treatment with the mPXR agonist PCN promotes hepatomegaly and lipid accumulation without hepatocyte proliferation in mice. Acta pharmacologica Sinica 4 35773338
2021 Identification of three novel mutations in PCNT in vietnamese patients with microcephalic osteodysplastic primordial dwarfism type II. Genes & genomics 4 33460028
2020 Novel compound heterozygous mutations of PCNT gene in MOPD type II with central precocious puberty. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 4 33016782
2019 Majewski dwarfism type II: an atypical neuroradiological presentation with a novel variant in the PCNT gene. BMJ case reports 4 31151966
2021 Coding variants in the PCNT and CEP295 genes contribute to breast cancer risk in Chinese women. Pathology, research and practice 3 34418690