Affinage

PCBP2

Poly(rC)-binding protein 2 · UniProt Q15366

Length
365 aa
Mass
38.6 kDa
Annotated
2026-06-10
100 papers in source corpus 50 papers cited in narrative 49 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PCBP2 (hnRNP E2) is a multifunctional KH-domain poly(C)-binding protein that governs gene expression post-transcriptionally through sequence-specific binding to C-rich/CU-rich elements in target mRNAs, with additional roles as a cytosolic iron chaperone, splicing regulator, and modulator of innate immune signaling (PMID:11753385, PMID:22055506, PMID:29866654). As a translational regulator, it binds the 5'UTR of CEBPA to block C/EBPα synthesis in BCR-ABL+ myeloid cells, a repression that requires ERK1/2-mediated phosphorylation at defined serine/threonine residues to stabilize PCBP2 and is relieved by miR-328 acting as a seed-independent RNA decoy that competes for binding (PMID:11753385, PMID:17475908, PMID:20211135). Conversely, PCBP2 binds C-rich elements in numerous 3'UTRs to stabilize their mRNAs—including STAT1/STAT2, p73, CDK2, collagen α1(I), and system Xc- components SLC3A2/SLC7A11—thereby tuning antiviral, senescence, proliferative, fibrotic, and ferroptosis programs (PMID:22022391, PMID:26907686, PMID:29744291, PMID:21643860, PMID:40486855). Independent of RNA binding, PCBP2 functions as an iron chaperone delivering Fe(II) to non-heme iron enzymes such as the HIF prolyl hydroxylases, asparaginyl hydroxylase FIH1, deoxyhypusine hydroxylase, and aconitase, and it binds ferroportin in an iron-dependent manner to support cellular iron handling (PMID:22055506, PMID:24843120, PMID:27302059). In innate immunity, sumoylated PCBP2 is recruited to MAVS—enhanced by NLRX1—to drive MAVS K48-linked polyubiquitination and proteasomal degradation, dampening interferon responses, and it separately interacts with cGAS to antagonize its condensation and enzymatic activity (PMID:26348439, PMID:28956771, PMID:35322803, PMID:41638535). PCBP2 also acts as a splicing regulator: it promotes Runx1 exon 6 inclusion required for definitive erythropoiesis and CD4+ T cell proliferation, and Pcbp2-null embryos die at midgestation with cardiovascular and hematopoietic defects (PMID:29866654, PMID:36632062, PMID:26527618). It is a structural co-factor for picornavirus IRES function, engaging poliovirus stem-loop IV via its KH domains in a complex remodeled by 3CD proteinase cleavage that switches the viral template from translation to replication (PMID:24371074, PMID:32556302). PCBP2 binds heavily oxidized (8-oxoG) RNA, forms phase-separating condensates, and inhibits SYNCRIP-dependent miRNA loading into extracellular vesicles, defining additional roles in stress responses, condensate biology, and intercellular RNA trafficking (PMID:32647012, PMID:41298370, PMID:40601477).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 2001 High

    Established that PCBP2/hnRNP E2 is a translational repressor controlling myeloid differentiation by binding the CEBPA 5'UTR, linking it to BCR-ABL leukemogenesis.

    Evidence Ectopic expression and CEBPA protein vs. mRNA readouts in myeloid precursors

    PMID:11753385

    Open questions at the time
    • Did not define the precise 5'UTR binding element
    • Mechanism of translational block (initiation step) not resolved
  2. 2007 High

    Resolved how oncogenic signaling activates PCBP2 by showing ERK1/2 phosphorylation at specific Ser/Thr sites stabilizes the protein and is required for CEBPA repression.

    Evidence Site-directed S/T→A mutagenesis, MAPK inhibition, differentiation rescue

    PMID:17475908

    Open questions at the time
    • How phosphorylation alters RNA-binding affinity structurally not shown
    • Phosphatase counter-regulation unaddressed
  3. 2010 High

    Defined a decoy mechanism whereby miR-328 binds PCBP2 seed-independently to derepress CEBPA, establishing a non-canonical RNA-protein regulatory axis.

    Evidence RNA-protein interaction and differentiation rescue assays in CML-BC blasts

    PMID:20211135

    Open questions at the time
    • Stoichiometry/affinity of miR-328 vs. mRNA competition not quantified
    • Whether other miRNAs use similar decoy logic unknown
  4. 2011 High

    Revealed a distinct biochemical activity—iron chaperoning—by showing PCBP1/2 deliver Fe(II) to HIF prolyl hydroxylases and FIH1, coupling PCBP2 to oxygen sensing.

    Evidence RNAi depletion, in vitro reconstitution with purified Fe-PCBP1, co-IP, hydroxylation assays

    PMID:22055506

    Open questions at the time
    • Direct PCBP2-PHD physical binding (vs. PCBP1) less defined
    • How a KH-domain protein coordinates iron structurally unresolved
  5. 2014 High

    Extended the iron-chaperone role to DOHH and aconitase, showing PCBP2 metallates multiple non-heme iron enzymes regulating hypusination and metabolism.

    Evidence siRNA depletion, in vitro metallation with lysates, co-IP, enzyme activity assays

    PMID:24843120

    Open questions at the time
    • Selectivity rules for which iron enzymes PCBP2 serves not established
    • Handoff mechanism to dinuclear sites unknown
  6. 2015 High

    Connected PCBP2 to iron efflux by demonstrating iron-dependent, paralog-specific binding to ferroportin required for cellular iron export.

    Evidence Reciprocal co-IP in yeast and mammalian systems, FPN1 domain mapping, iron export assay

    PMID:27302059

    Open questions at the time
    • Structural basis of iron-dependent FPN1 recognition not shown
    • Directionality of iron transfer at the membrane unresolved
  7. 2015 High

    Identified PCBP2 as a negative regulator of innate immunity, with IRTKS-driven sumoylation triggering cytoplasmic relocation and MAVS degradation.

    Evidence Sumoylation assays, fractionation, MAVS ubiquitination/degradation with proteasome inhibitors

    PMID:26348439

    Open questions at the time
    • Identity of the E3 ligase ubiquitinating MAVS in this pathway not defined
    • Which SUMO acceptor lysines on PCBP2 unmapped
  8. 2015 High

    Demonstrated a non-redundant in vivo requirement for PCBP2 in development, with knockout embryos dying at midgestation from cardiovascular and hematopoietic defects.

    Evidence Targeted knockout mouse, histological and hematopoietic analysis

    PMID:26527618

    Open questions at the time
    • Molecular target mediating the embryonic phenotype not pinpointed in this study
    • Tissue-of-origin of lethality unresolved
  9. 2015 Medium

    Established PCBP2 as a 3'UTR-binding mRNA stabilizer in antiviral defense by stabilizing STAT1/STAT2 transcripts to enhance IFN-α activity.

    Evidence RIP-qPCR, half-life assays, biotinylated 3'UTR pull-down in HCV replicon cells

    PMID:22022391

    Open questions at the time
    • How stabilization mechanistically opposes its MAVS-degrading role not reconciled
    • Single lab
  10. 2016 Medium

    Broadened the 3'UTR-stabilization principle across cell-fate and disease contexts (p73, CDK2, ARHGDIA, GPR56, collagen), showing PCBP2 can also prime miRNA access via local RNA structural change.

    Evidence RIP, mRNA stability and structure-probing assays, functional epistasis in glioma/gastric/cardiac models

    PMID:26116532 PMID:26761212 PMID:26907686 PMID:29744291

    Open questions at the time
    • Rules determining stabilization vs. destabilization of a bound mRNA unresolved
    • Individual targets validated in single labs
  11. 2018 High

    Defined a developmentally critical splicing function: PCBP2 promotes Runx1 exon 6 inclusion required for definitive erythropoiesis, validated by phenocopy.

    Evidence Knockout mouse, RNA-seq splicing, Runx1ΔE6 genetic phenocopy

    PMID:29866654

    Open questions at the time
    • Cis-elements bound on Runx1 pre-mRNA not mapped
    • Spliceosomal partners mediating inclusion unknown
  12. 2020 High

    Revealed PCBP2 senses oxidized RNA (8-oxoG) via its RNA-binding domains and suppresses apoptosis under oxidative stress, opposite to PCBP1.

    Evidence 8-oxoG RNA binding assays, RBD mutagenesis, PCBP2-KO cells with caspase/PARP readouts

    PMID:32647012

    Open questions at the time
    • Downstream effectors of the anti-apoptotic effect not identified
    • Fate of oxidized RNA bound by PCBP2 unknown
  13. 2020 High

    Resolved the structural basis of PCBP2's IRES co-factor activity and how viral 3CD cleavage remodels the complex to switch translation to replication.

    Evidence 6.1 Å cryo-EM of PCBP2-poliovirus SLIVm plus SEC-SAXS, SHAPE, REMSA, limited proteolysis

    PMID:24371074 PMID:32556302

    Open questions at the time
    • Atomic-resolution contacts not achieved at 6.1 Å
    • Generalizability to other picornaviral IRESs only partially tested
  14. 2021 High

    Showed PCBP1 and PCBP2 act together to sustain the erythroid/hematopoietic transcriptome and splicing program, with combined loss causing fetal demise.

    Evidence Conditional double knockout mouse, RNA-seq, ex vivo erythroid progenitor cultures

    PMID:34180713

    Open questions at the time
    • Paralog-specific vs. shared targets only partially separated
    • Direct binding maps not generated
  15. 2022 High

    Identified a second innate-immune brake: PCBP2 binds cGAS and antagonizes its phase separation to limit cGAMP production and STING signaling.

    Evidence Co-IP, cGAMP and cGAS condensation assays, gain/loss with STING readout

    PMID:35322803

    Open questions at the time
    • Whether RNA binding is required for cGAS regulation unclear
    • Structural basis of condensation antagonism unknown
  16. 2024 High

    Established PCBP2 (with PCBP1) as essential for β cell function and global translation by stabilizing mRNAs of the insulin secretory pathway and translation machinery.

    Evidence β cell-specific single and double knockouts, RIP, mRNA stability, puromycin labeling, calcium/EM/secretion assays

    PMID:38950317 PMID:40451383

    Open questions at the time
    • Direct binding sites on translation-factor mRNAs not fully enumerated
    • Relative contributions of stabilization vs. splicing in β cells unresolved
  17. 2025 High

    Defined PCBP2 as a regulator of intercellular RNA trafficking, acting as a dominant inhibitor or promoter of miRNA loading into extracellular vesicles depending on motif and context.

    Evidence CLIP, RNA pull-down, proteomics, EMSA, SYNCRIP knockdown and EV miRNA quantification; EGFR-driven angiogenesis models

    PMID:39816681 PMID:40601477

    Open questions at the time
    • Apparent opposing effects on EV miRNA loading across contexts not mechanistically reconciled
    • Determinants switching inhibitory vs. promoting roles unknown
  18. 2025 Medium

    Implicated PCBP2 condensation and DNA-structure binding in disease and replication, linking phase separation to Alzheimer's pathology and i-motif/G-quadruplex resolution during genome replication.

    Evidence Phase separation/proteomics with AD models and CN-0928; single-molecule force spectroscopy on i-motif DNA

    PMID:41298370 PMID:41327866

    Open questions at the time
    • DNA-binding activity is a single-study novel finding awaiting independent confirmation
    • Physiological trigger of pathological condensation unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how PCBP2 integrates its disparate activities—mRNA stabilization vs. degradation, iron chaperoning, splicing, innate-immune suppression, and condensate formation—and what determines target and activity selection in a given cell.
  • No unifying model linking RNA-binding to iron-chaperone functions
  • Determinants of stabilization vs. destabilization of bound mRNAs unknown
  • Switching logic between immune-promoting and immune-suppressing outcomes undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 6 GO:0045182 translation regulator activity 3 GO:0140104 molecular carrier activity 3 GO:0098772 molecular function regulator activity 2 GO:0003677 DNA binding 1
Localization
GO:0005634 nucleus 3 GO:0005829 cytosol 3
Pathway
R-HSA-1430728 Metabolism 4 R-HSA-168256 Immune System 4 R-HSA-8953854 Metabolism of RNA 4 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-392499 Metabolism of proteins 1
Partners
CGASDHX30FPN1MAVSNLRX1PARP1SRP75SYNCRIP

Evidence

Reading pass · 49 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 hnRNP E2 (PCBP2) binds the 5'UTR of CEBPA mRNA and inhibits its translation, thereby suppressing C/EBPα protein expression in BCR-ABL-expressing myeloid precursor cells. BCR-ABL induces hnRNP E2 expression to mediate this translational block. Ectopic expression of hnRNP E2, Western blot for C/EBPα protein vs. CEBPA mRNA levels, functional differentiation assay Nature genetics High 11753385
2007 BCR/ABL-activated MAPK(ERK1/2) phosphorylates hnRNP E2 (PCBP2) at serines 173, 189, 272 and threonine 213, stabilizing the protein. Phosphorylation is required for hnRNP E2 binding to the 5'UTR of CEBPA mRNA; serine/threonine to alanine substitutions abolish phosphorylation, decrease hnRNP E2 stability, and restore C/EBPα expression and granulocytic differentiation. Site-directed mutagenesis (S→A substitutions), pharmacologic MAPK inhibition, in vitro/in vivo differentiation assays, binding assays to CEBPA 5'UTR Blood High 17475908
2010 miR-328 acts as a decoy by binding directly to hnRNP E2 (PCBP2) in a seed-sequence-independent manner, competing with CEBPA mRNA for hnRNP E2 binding, thereby releasing CEBPA mRNA from hnRNP E2-mediated translational inhibition. RNA-protein interaction assays, rescue differentiation assays, miR-328 restoration in CML-BC blasts Cell High 20211135
2011 PCBP1 and PCBP2 function as iron chaperones that deliver Fe(II) to the HIF prolyl hydroxylases (PHD1/2/3) and asparaginyl hydroxylase FIH1. Depletion of PCBP1 or PCBP2 reduces PHD activity, impairs prolyl hydroxylation of HIF1α, and causes HIF1α accumulation; PHD activity is restored in vitro by adding purified Fe-PCBP1. PCBP1 physically binds PHD2 and FIH1 in vivo. RNAi depletion, in vitro activity reconstitution with purified Fe-PCBP1, co-immunoprecipitation (PCBP1 with PHD2/FIH1), HIF1α hydroxylation and degradation assays Cell metabolism High 22055506
2011 UPF1 regulates hnRNP E2 (PCBP2) targets in myeloid differentiation. miR-328, induced during monocytic differentiation, acts as an RNA decoy for hnRNP E2, antagonizing its splicing-regulatory function on target pre-mRNAs (including S100A9) in 5'UTR introns, leading to upregulation of CD11b expression and ROS production. RNAi knockdown of UPF1/hnRNP E2, miR-328 overexpression, differentiation assays, splicing analysis Scientific reports Medium 27573788
2013 PCBP2 is involved in poliovirus IRES-mediated translation initiation; viral proteinase 3CD cleaves PCBP2 in its linker region, which inhibits cap-independent translation but the cleaved form remains active in viral RNA replication. Inhibiting PCBP2 cleavage reduces viral RNA replication efficiency, indicating cleavage mediates a switch from translation to RNA replication. Proteinase inhibition, viral replication assays, analysis of cleaved vs. intact PCBP2 function Journal of virology Medium 24371074
2013 PCBP2 and hnRNP A1 bind to both the 5' and 3' ends of murine norovirus (MNV-1) genomic RNA, stabilize 5'-3' RNA-RNA interactions, and induce circularization of the viral RNA. siRNA knockdown of PCBP2 or hnRNP A1 reduces virus yield, establishing a role for PCBP2 in RNA circularization required for efficient viral replication. RNA co-precipitation with antibodies, recombinant protein binding assays, electron microscopy of RNA circularization, siRNA knockdown with viral titer readout Journal of virology Medium 23946460
2013 PCBP2 promotes glioma cell growth by binding FHL3 mRNA and destabilizing it, thereby suppressing FHL3 protein expression. Knockdown of PCBP2 stabilizes FHL3 mRNA and increases FHL3 protein, inducing apoptosis; FHL3 overexpression phenocopies PCBP2 knockdown. RIP-ChIP protein-RNA interaction arrays, mRNA stability assay, knockdown/overexpression, in vitro and in vivo growth assays The Journal of clinical investigation Medium 23585479
2014 PCBP1 and PCBP2 deliver iron to deoxyhypusine hydroxylase (DOHH), a dinuclear iron enzyme required for hypusine modification of eIF5A. Cells depleted of PCBP1 or PCBP2 lose DOHH activity; lysates containing PCBP1/2 convert apo-DOHH to holo-DOHH in vitro with greater efficiency than depleted lysates. PCBP1 physically binds DOHH in iron-treated cells. PCBP depletion also reduced cytosolic aconitase activity without full [4Fe-4S] cluster disassembly. siRNA depletion, in vitro metallation reconstitution with cell lysates, co-immunoprecipitation of PCBP1 with DOHH, enzyme activity assays Proceedings of the National Academy of Sciences of the United States of America High 24843120
2015 PCBP2 (but not PCBP1, PCBP3, or PCBP4) specifically binds ferroportin 1 (FPN1) in an iron-dependent manner, interacting with the C-terminal cytoplasmic region of FPN1. Iron-loaded but not iron-depleted PCBP2 interacts with FPN1. Silencing PCBP2 suppresses FPN1-dependent iron export from cells. Yeast and mammalian co-immunoprecipitation, domain mapping of FPN1 binding site, siRNA knockdown with iron export assay The Journal of biological chemistry High 27302059
2015 PCBP2 contains nuclear-cytoplasmic shuttling activity and localizes to cytoplasmic stress granules (SGs) and a subset (~40%) of P-bodies under normal and stress conditions. Under heat or arsenic stress, PCBP2 accumulates predominantly at SGs but remains in Dcp1a-positive P-bodies. FRAP demonstrates PCBP2 dynamically moves in and out of SGs and P-bodies. Immunofluorescence, live-cell imaging, FRAP, subcellular fractionation RNA (New York, N.Y.) / Biochimica et biophysica acta Medium 18174314 19230839
2015 IRTKS recruits the E2 SUMO ligase Ubc9 to sumoylate PCBP2 in the nucleus. Sumoylation causes PCBP2 cytoplasmic translocation during viral infection, where sumoylated PCBP2 associates with MAVS to initiate its K48-linked polyubiquitination and proteasomal degradation, attenuating antiviral signaling. Co-immunoprecipitation, sumoylation assays, subcellular fractionation, MAVS degradation assays with proteasome inhibitors, IRTKS knockdown Nature communications High 26348439
2015 Pcbp2-null mouse embryos develop normally until midgestation (E12.5–13.5) but then undergo lethality associated with combined cardiovascular and hematopoietic abnormalities, demonstrating a non-redundant in vivo role for PCBP2 in hematopoiesis. Pcbp1 and Pcbp2 are individually essential for mouse embryonic development with distinct lethal stages. Targeted knockout mouse model, histological and hematopoietic analysis of embryos Molecular and cellular biology High 26527618
2015 PCBP2 promotes stabilization of STAT1 and STAT2 mRNAs by binding C-rich elements in their 3'UTRs. This stabilization increases STAT1/STAT2 protein expression and phosphorylation, enhancing IFN-α antiviral activity against HCV. RIP-qRT-PCR, RNA half-life assays, RNA pull-down with biotinylated 3'UTR, overexpression and knockdown in HCV replicon cells PloS one Medium 22022391
2015 STAT3 transcriptionally activates PCBP2 in EBV-positive B cells; high PCBP2 expression renders individual cells refractory to EBV lytic cycle activation. Suppression of PCBP2 levels is sufficient to increase the number of EBV lytic cells, placing PCBP2 downstream of STAT3 as a mediator of EBV latency maintenance. ChIP-seq analysis of STAT3 binding at PCBP2 locus, siRNA knockdown of PCBP2, separation of lytic vs. refractory cells, transcriptome analysis Journal of virology Medium 25717101
2015 PCBP2 inhibits cardiac hypertrophy by promoting degradation of GPR56 mRNA in cardiomyocytes. PCBP2 knockdown enhances Ang II-induced hypertrophy; PCBP2 overexpression reverses it. GPR56 knockdown partially blocks PCBP2-dependent hypertrophic effects. Knockdown and overexpression in neonatal cardiomyocytes/H9C2 cells, mRNA stability assays, cell size and protein synthesis readouts Biochemical and biophysical research communications Medium 26116532
2016 PCBP2 binds the 3'UTR of ARHGDIA mRNA and induces a local RNA structural change that favors subsequent binding of miR-151-5p and miR-16, suppressing ARHGDIA expression and promoting glioma cell migration and invasion. RIP, RNA structure probing, miRNA target assays, in vitro and in vivo migration/invasion assays Oncotarget Medium 26761212
2016 PCBP2 binds the 3'UTR of CDK2 mRNA and stabilizes it, positively regulating CDK2 protein expression. CDK2 mediates PCBP2's pro-viability effect in gastric cancer cells. Ribonucleoprotein immunoprecipitation (RIP), biotin pulldown of CDK2 3'UTR, mRNA stability assay, CDK2 knockdown rescue FEBS open bio Medium 29744291
2016 PCBP2 facilitates IRES-mediated c-myc translation via internal ribosome entry segment (IRES), downstream of β2-adrenergic receptor (β2-AR) signaling. β2-AR stimulation promotes PCBP2-β2-AR interaction, and knockdown of PCBP2 blocks β2-AR-induced c-myc protein increase. Immunoprecipitation-mass spectrometry (IP-MS), reciprocal co-IP, IRES reporter assay, siRNA knockdown Cancer letters Medium 26803058
2016 SIRT6 suppresses PCBP2 expression in glioma by deacetylating H3K9ac at the PCBP2 promoter; SIRT6 levels are negatively correlated with PCBP2 and H3K9ac enrichment on the PCBP2 promoter. ChIP for H3K9ac at PCBP2 promoter, SIRT6 overexpression/knockdown, correlation analysis of SIRT6 and PCBP2 levels, in vitro and in vivo growth assays Biochemical and biophysical research communications Medium 24607900
2016 PCBP2 regulates p73 (TAp73) expression by binding CU-rich elements in the p73 3'UTR and stabilizing p73 mRNA. PCBP2 knockout in MEFs decreases p73 expression and increases ROS production and cellular senescence in a TAp73-dependent manner. PCBP2 knockout and overexpression, mRNA stability assays, 3'UTR binding assays, ROS measurement, MEF senescence assay The Journal of biological chemistry Medium 26907686
2017 NLRX1 recruits PCBP2 to MAVS, inducing K48-linked polyubiquitination and proteasomal degradation of MAVS during HCV infection, thereby attenuating interferon signaling. The NOD domain of NLRX1 is required for interaction with PCBP2. Mutagenesis confirmed domain requirements for PCBP2-NLRX1 interaction. Co-immunoprecipitation, mutagenesis of NLRX1 domains, ubiquitination assay, proteasome inhibitor treatment, NLRX1/PCBP2 depletion with IFN signaling readout Journal of virology High 28956771
2017 An SRp75/hnRNPG complex interacts with hnRNP E2 (PCBP2), which activates splicing of tau exon 10. SRp75 binds the proximal downstream intron at the FTDP-17 hotspot region; hnRNPG and hnRNP E2 interact with SRp75 as shown by co-immunoprecipitation and co-transfection. Co-immunoprecipitation, RNAi knockdown, co-transfection splicing reporter assays Gene Medium 21723381
2018 Pcbp2 enables definitive erythropoiesis by promoting inclusion of exon 6 of the Runx1 transcript. Pcbp2-null embryos show accentuated exclusion of Runx1 exon 6. Embryos homozygous for a Runx1 locus lacking exon 6 phenocopy the loss of definitive erythroid lineage in Pcbp2−/− embryos. Knockout mouse model, RNA-seq splicing analysis, Runx1 exon 6 conditional deletion (Runx1ΔE6) phenocopy Molecular and cellular biology High 29866654
2019 PCBP2 isoform f interacts with the 5'UTR of eIF4G2 (DAP5) and Cyclin I mRNAs and inhibits their translation. eIF4G2, in turn, participates in cap-dependent translation of PCBP2 mRNA, forming a feedback loop between the translation factor and the RNA-binding protein. In vitro translation assay, cell-based translation reporter assay, RNA-binding assays, isoform-specific analysis RNA (New York, N.Y.) Medium 31010886
2020 PCBP2 binds specifically to RNA carrying two closely spaced 8-oxoguanine (8-oxoG) residues (heavily oxidized RNA) via its conserved RNA-binding domains; mutations in these domains disrupt the interaction. In cells, PCBP2 suppresses apoptosis under oxidative conditions (opposite to PCBP1 which promotes apoptosis), as PCBP2-KO cells show increased caspase-3 activity and PARP1 cleavage under oxidative stress. Binding assays with 8-oxoG-containing RNA, site-directed mutagenesis of RNA-binding domains, PCBP2 knockout cell lines, caspase-3 activity and PARP cleavage assays The Journal of biological chemistry High 32647012
2020 PCBP2 and DHX30 bind a CG-rich 3'UTR motif (CGPD-motif) and form a complex that represses translation of mRNAs carrying this motif in cells undergoing p53-dependent cell cycle arrest. Upon DHX30 depletion, CGPD-motif mRNA translation increases and the p53 response shifts toward apoptosis. Polysome profiling, UV-crosslinking/RIP to identify CGPD-motif interactors, DHX30 depletion/overexpression, translation and apoptosis assays Cell reports Medium 32234473
2020 PCBP2 binds C-rich elements in the 3'UTR of sortilin mRNA and stabilizes it. Knockdown of PCBP2 decreases sortilin transcripts. Zn2+ reversibly inhibits the nucleotide-binding ability of PCBP2 in vitro, suggesting a Zn2+-sensitive mRNA stabilization mechanism. PCBP2 knockdown, mRNA stability assay, in vitro Zn2+ inhibition of RNA binding FEBS open bio Medium 31961070
2020 PCBP2 stabilizes type I collagen α1(I) mRNA by binding its 3' end, increasing mRNA half-life. Alcohol upregulates PCBP2 in hepatic stellate cells, leading to increased collagen mRNA stability; siRNA knockdown of PCBP2 increases the decay rate of collagen α1(I) mRNA. PCBP2 siRNA, in vitro mRNA decay assay, Western blot for PCBP2 and collagen Pharmaceutical research Medium 21643860
2020 PCBP2 directly binds the 3'UTR of RRM1 mRNA and cooperates with LINC02535 lncRNA to stabilize RRM1 mRNA. PCBP2 and LINC02535 co-localize in the cytoplasm, and together they promote DNA damage repair in cervical cancer cells. Co-IP, RIP, mRNA stability assay, co-localization by immunofluorescence, knockdown of PCBP2/LINC02535 Journal of cellular physiology Low 32324262
2020 PCBP2 structure: cryo-EM reconstruction of full-length PCBP2 in complex with the apical region of poliovirus IRES stem-loop IV (SLIVm) resolved to 6.1 Å. PCBP2 interacts with the cruciform RNA via KH domains, featuring a prominent GNRA tetraloop. Cleavage of PCBP2 in its linker region by poliovirus 3CD proteinase makes the complex more flexible and reduces PCBP2 affinity for SLIVm, as shown by SEC-SAXS, SHAPE, hydroxyl-radical cleavage, and limited proteolysis/REMSA. CryoEM structure determination, SEC-SAXS, SHAPE analysis, hydroxyl-radical cleavage, REMSA, limited proteolysis Nucleic acids research High 32556302
2022 PCBP2 directly interacts with cGAS and negatively regulates its enzymatic activity by antagonizing cGAS condensation (phase separation), reducing cGAMP production and thereby dampening cGAS-STING antiviral signaling. PCBP2 overexpression reduces antiviral signaling; PCBP2 loss increases cGAS activity. Co-immunoprecipitation, cGAMP production assay, cGAS condensation assay, PCBP2 overexpression/depletion with STING signaling readout Nature communications High 35322803
2021 PCBP1 and PCBP2 are together required for erythroid differentiation; combined conditional inactivation causes midgestational repression of erythroid/hematopoietic gene expression, loss of blood formation, and fetal demise. They mediate overlapping and isoform-specific impacts on hematopoietic lineage transcriptome including mRNA representation and exon splicing. Conditional double knockout mouse model, RNA-seq transcriptome and splicing analysis, ex vivo primary erythroid progenitor cultures Molecular and cellular biology High 34180713
2021 PCBP2 knockdown in malignant mesothelioma cells significantly decreases TfR1 and FTH expression and inhibits proliferation, indicating stagnation of intracellular iron transport. PCBP2 knockdown increases sensitivity to erastin-induced ferroptosis by increasing catalytic Fe(II) levels. siRNA knockdown, Western blot for TfR1/FTH, Fe(II) measurement, erastin-induced ferroptosis assay Pathology international Medium 35089637
2021 PCBP2 knockdown in pancreatic stellate cells and fibroblasts reverses accumulation of type I collagen in the extracellular matrix, normalizing desmoplastic stroma and enhancing drug penetration into PDAC tumors. siRNA knockdown, in vitro collagen quantification, spheroid drug penetration assay, orthotopic mouse model Theranostics Medium 33500719
2021 PCBP2 knockdown in extravillous trophoblasts (EVTs) impairs differentiation toward an invasive phenotype and causes transcript switching (alternative splicing) in genes controlling cellular assembly, proliferation, and cell cycle, with minimal effect on mRNA expression levels. siRNA knockdown, RNA-seq splicing analysis, Transwell invasion assay, placental explant culture Frontiers in cell and developmental biology Medium 34095140
2022 Pcbp2 is essential for CD4+ T cell (Tconv) proliferation via regulation of co-stimulatory signaling. Pcbp2 deficiency in the CD4+ lineage does not affect Treg function but impairs Tconv proliferation and in vivo activation. Pcbp2 controls Runx1 exon 6 splicing in CD4+ T cells, connecting this splicing function to peripheral lymphocyte pool maintenance. Conditional Pcbp2 knockout in CD4+ T cells, proliferation assay, adoptive transfer colitis model, splicing analysis of Runx1 exon 6 iScience Medium 36632062
2024 PCBP2 is required for pancreatic β cell function and adaptation to glucose. PCBP2 is induced by elevated glucose in primary mouse islets; Pcbp2-deficient β cells exhibit defects in calcium flux, insulin granule ultrastructure and exocytosis, and the amplification pathway of insulin secretion. PCBP2 impacts basal and glucose-regulated mRNAs encoding core components of the insulin secretory pathway. β cell-specific Pcbp2 knockout, transcriptomic analysis, calcium flux assay, electron microscopy of insulin granules, insulin secretion assay The Journal of clinical investigation High 38950317
2024 PCBP1 and PCBP2 are required together for sustaining global mRNA translation in pancreatic β cells by stabilizing mRNAs encoding core translation initiation factors and ribosomal proteins through direct binding. Combined Pcbp1/2 deletion causes severe diabetes due to compromised β cell viability. β cell-specific Pcbp1 and combined Pcbp1/2 knockout, scRNA-seq, RIP for mRNA-protein interactions, mRNA stability assays, puromycin labeling for global translation monitoring Molecular metabolism High 40451383
2024 PCBP2 stabilizes the mRNA of system Xc- components (SLC3A2/SLC7A11) and limits HIF1α/p300-HMGB1 signaling. In hepatic ischemia-reperfusion injury (HIRI), decreased PCBP2 compromises system Xc- stability, promotes ferroptosis, and enables HIF1α-driven HMGB1 secretion that worsens macrophage recruitment. PCBP2 knockdown in hepatocytes, mRNA stability assay for Slc3a2/Slc7a11, binding assay, HIRI mouse model with hepatocyte-specific PCBP2 knockdown Acta pharmaceutica Sinica. B Medium 40486855
2024 Duck PCBP2 promotes DHAV-1 (picornavirus) replication via KH1 domain (aa 1–92) interaction with the viral RNA-dependent RNA polymerase 3Dpol, and facilitates IRES-mediated translation through interaction with stem-loop domains II and III of the DHAV-1 IRES. Biotinylated RNA pull-down, co-IP with 3Dpol, domain-specific interaction mapping, viral replication/translation assays Veterinary research Medium 39300570
2025 PCBP2 acts as a direct interactor of an intracellular retention motif on miRNAs, binding miRNAs containing this motif (demonstrated by CLIP, RNA pull-down, and proteomics). PCBP2 requires SYNCRIP (an EV miRNA loader) for binding, as shown by SYNCRIP knockdown abolishing PCBP2-miRNA interaction. PCBP2 and SYNCRIP can co-bind miRNAs simultaneously (EMSA). PCBP2 acts as a dominant inhibitor of SYNCRIP-dependent miRNA loading into extracellular vesicles. CLIP coupled to RNA pull-down and proteomics, mutagenesis of retention motif, SYNCRIP knockdown, EMSA, PCBP2 knockdown with EV miRNA quantification eLife High 40601477
2025 PCBP2 directly interacts with PARP1 mRNA, inhibiting m6A methylation at PARP1 mRNA and stabilizing it, leading to increased PARP1 expression and enhanced DNA repair activity that contributes to olaparib resistance in BRCA-mutated breast cancer. Co-IP of PCBP2 with PARP1 mRNA, m6A methylation assay, mRNA stability assay, knockdown/overexpression functional resistance assay Cancer research Medium 40773674
2025 PCBP2 forms biomolecular condensates via phase separation in Alzheimer's disease brain. These condensates sequester mitochondrial and mRNA-binding proteins, impairing mitochondrial function and BACE1 mRNA stability. The small molecule CN-0928 binds INTS1, reduces PCBP2 protein level, inhibits condensate formation, and mitigates AD pathology. Phase separation assays, proteomics of condensate contents, PCBP2 level modulation, AD mouse models, CN-0928 target identification (INTS1 binding), cognitive readouts Nature communications Medium 41298370
2025 PCBP2 is identified as an i-motif DNA-interacting protein. By destabilizing the i-motif structure, PCBP2 simultaneously reduces the mechanical stability of the facing G-quadruplex (by ~13.7 kcal/mol), enabling a replisome to bypass these DNA structural barriers during genome replication. Single-molecule force spectroscopy, PCBP2 identification as i-motif binding protein, quantitative mechanical stability measurements Angewandte Chemie (International ed. in English) Medium 41327866
2025 A lncRNA BASP1-AS1 assembles a complex with ULK1 and LDHA, activating LDHA to increase lactate, which triggers PCBP2 K115 lactylation. This modification disrupts PCBP2-ARIH2 interaction, inhibiting ubiquitin-dependent degradation and stabilizing PCBP2 protein, which then suppresses ferroptosis and confers oxaliplatin resistance in gastric cancer. Multi-omics profiling, co-IP, ubiquitination assay, protein stability assay, LDHA activity assay, K115 lactylation site identification, organoid models Free radical biology & medicine Medium 40914325
2025 PCBP2 promotes MAVS K48-linked polyubiquitination and proteasomal degradation during Dabie bandavirus (DBV/SFTS virus) infection, suppressing the MAVS-TBK1-IRF3 axis and type I interferon responses. PCBP2 overexpression enhances DBV replication; knockdown reduces it. Co-IP of PCBP2 with MAVS, ubiquitination assay, proteasome inhibitor treatment, PCBP2 overexpression/knockdown with IFN signaling and viral replication readouts Virus research Medium 41638535
2016 PCBP2 was identified as the direct binding target of the immunosuppressive agent 15-deoxyspergualin (DSG) by pull-down assay. DSG treatment shifts PCBP2 intracellular localization from nucleus to cytoplasm. Overexpression of PCBP2 reduces the anti-proliferative activity of DSG. Biotinylated DSG probe pull-down, DSG binding confirmation, subcellular fractionation after DSG treatment, PCBP2 overexpression rescue assay Biochemical and biophysical research communications Low 27261432
2025 PCBP2 promotes EGFR-driven tumor angiogenesis by binding miRNAs containing a 'GGGU' motif and promoting their loading into small extracellular vesicles (sEVs). EGFR overexpression transcriptionally upregulates PCBP2 protein, strengthening its binding to these miRNAs and their secretion via sEVs. PCBP2 depletion impairs EGFR-driven angiogenesis. miRNA pull-down assays, small RNA sequencing, PCBP2 depletion with sEV miRNA quantification, EGFR overexpression, co-culture and murine tumor models Theranostics Medium 39816681

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell 412 20211135
2001 BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2. Nature genetics 261 11753385
2011 Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2. Cell metabolism 176 22055506
2016 Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2. The Journal of biological chemistry 136 27302059
2014 Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase. Proceedings of the National Academy of Sciences of the United States of America 113 24843120
2013 RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3. The Journal of clinical investigation 94 23585479
2007 High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C/EBPalpha-driven myeloid differentiation. Blood 76 17475908
2017 NLRX1 Mediates MAVS Degradation To Attenuate the Hepatitis C Virus-Induced Innate Immune Response through PCBP2. Journal of virology 73 28956771
2008 Identification of PCBP2, a facilitator of IRES-mediated translation, as a novel constituent of stress granules and processing bodies. RNA (New York, N.Y.) 68 18174314
2015 The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development. Molecular and cellular biology 61 26527618
2019 KCNQ1OT1 aggravates cell proliferation and migration in bladder cancer through modulating miR-145-5p/PCBP2 axis. Cancer cell international 56 31827399
2015 IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation. Nature communications 48 26348439
2014 The RNA-binding protein PCBP2 facilitates gastric carcinoma growth by targeting miR-34a. Biochemical and biophysical research communications 43 24796666
2013 Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication. Journal of virology 43 24371074
2015 The RNA-binding protein PCBP2 inhibits Ang II-induced hypertrophy of cardiomyocytes though promoting GPR56 mRNA degeneration. Biochemical and biophysical research communications 40 26116532
2016 Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion. Oncotarget 39 26761212
2018 Poly(rC) binding protein 2 (PCBP2) promotes the viability of human gastric cancer cells by regulating CDK2. FEBS open bio 38 29744291
2015 Cellular STAT3 functions via PCBP2 to restrain Epstein-Barr Virus lytic activation in B lymphocytes. Journal of virology 38 25717101
2016 β2-adrenergic receptor signaling promotes pancreatic ductal adenocarcinoma (PDAC) progression through facilitating PCBP2-dependent c-myc expression. Cancer letters 37 26803058
2020 LINC02535 co-functions with PCBP2 to regulate DNA damage repair in cervical cancer by stabilizing RRM1 mRNA. Journal of cellular physiology 35 32324262
2011 An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementia. Gene 35 21723381
2020 PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions. The Journal of biological chemistry 34 32647012
2014 The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma. Biochemical and biophysical research communications 34 24607900
2022 PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation. Nature communications 33 35322803
2020 Structure of the PCBP2/stem-loop IV complex underlying translation initiation mediated by the poliovirus type I IRES. Nucleic acids research 31 32556302
2008 A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress. Proceedings of the National Academy of Sciences of the United States of America 31 18687895
2020 PCBP2 Posttranscriptional Modifications Induce Breast Cancer Progression via Upregulation of UFD1 and NT5E. Molecular cancer research : MCR 30 33037085
2019 PCBP2 promotes the development of glioma by regulating FHL3/TGF-β/Smad signaling pathway. Journal of cellular physiology 30 31693182
2022 PCBP2 knockdown promotes ferroptosis in malignant mesothelioma. Pathology international 26 35089637
2021 Silencing PCBP2 normalizes desmoplastic stroma and improves the antitumor activity of chemotherapy in pancreatic cancer. Theranostics 26 33500719
2020 Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30. Cell reports 24 32234473
2016 RNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant Defense. The Journal of biological chemistry 23 26907686
2015 MicroRNA-214 targets PCBP2 to suppress the proliferation and growth of glioma cells. International journal of clinical and experimental pathology 23 26722446
2013 Norovirus genome circularization and efficient replication are facilitated by binding of PCBP2 and hnRNP A1. Journal of virology 23 23946460
2012 The 3' untranslated region of the rabies virus glycoprotein mRNA specifically interacts with cellular PCBP2 protein and promotes transcript stability. PloS one 23 22438951
2007 HnRNP E2 is downregulated in human oral cancer cells and the overexpression of hnRNP E2 induces apoptosis. Molecular carcinogenesis 23 17219427
2009 Selective localization of PCBP2 to cytoplasmic processing bodies. Biochimica et biophysica acta 22 19230839
2011 PCBP2 enhances the antiviral activity of IFN-α against HCV by stabilizing the mRNA of STAT1 and STAT2. PloS one 21 22022391
2021 The circular RNA circ_GRHPR promotes NSCLC cell proliferation and invasion via interactions with the RNA-binding protein PCBP2. Clinical and experimental pharmacology & physiology 20 33987874
2021 H3K27ac-induced lncRNA PAXIP1-AS1 promotes cell proliferation, migration, EMT and apoptosis in ovarian cancer by targeting miR-6744-5p/PCBP2 axis. Journal of ovarian research 20 34108034
2017 Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration. Acta neuropathologica communications 20 28666471
2020 LncRNA ST8SIA6-AS1 promotes colorectal cancer cell proliferation, migration and invasion by regulating the miR-5195/PCBP2 axis. European review for medical and pharmacological sciences 19 32373956
2019 eIF4G2 balances its own mRNA translation via a PCBP2-based feedback loop. RNA (New York, N.Y.) 18 31010886
2016 UPF1 regulates myeloid cell functions and S100A9 expression by the hnRNP E2/miRNA-328 balance. Scientific reports 18 27573788
2014 Chaperone turns gatekeeper: PCBP2 and DMT1 form an iron-transport pipeline. The Biochemical journal 16 25057890
2011 PCBP2 siRNA reverses the alcohol-induced pro-fibrogenic effects in hepatic stellate cells. Pharmaceutical research 16 21643860
2025 Acteoside ameliorates hepatocyte ferroptosis and hepatic ischemia-reperfusion injury via targeting PCBP2. Acta pharmaceutica Sinica. B 15 40486855
2024 RNA-binding protein PCBP2 regulates pancreatic β cell function and adaptation to glucose. The Journal of clinical investigation 15 38950317
2021 RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis. Molecular and cellular biology 15 34180713
2016 PCBP2 Modulates Neural Apoptosis and Astrocyte Proliferation After Spinal Cord Injury. Neurochemical research 15 27209304
2022 PCBP2 Reduced Oxidative Stress-Induced Apoptosis in Glioma through cGAS/STING Pathway by METTL3-Mediated m6A Modification. Oxidative medicine and cellular longevity 14 36267817
2019 Heterogeneous Nuclear Ribonucleoprotein E2 (hnRNP E2) Is a Component of TDP-43 Aggregates Specifically in the A and C Pathological Subtypes of Frontotemporal Lobar Degeneration. Frontiers in neuroscience 14 31213972
2016 PCBP2 enables the cadicivirus IRES to exploit the function of a conserved GRNA tetraloop to enhance ribosomal initiation complex formation. Nucleic acids research 14 27387282
2016 Poly (C)-binding protein 2 (PCBP2) promotes the progression of esophageal squamous cell carcinoma (ESCC) through regulating cellular proliferation and apoptosis. Pathology, research and practice 14 27461833
2019 A Combined ELONA-(RT)qPCR Approach for Characterizing DNA and RNA Aptamers Selected against PCBP-2. Molecules (Basel, Switzerland) 13 30925703
2015 PCBP2 regulates hepatic insulin sensitivity via HIF-1α and STAT3 pathway in HepG2 cells. Biochemical and biophysical research communications 12 26002461
2023 The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2. Cellular signalling 11 37544634
2021 Upregulation of a novel LncRNA AC104958.2 stabilized by PCBP2 promotes proliferation and microvascular invasion in hepatocellular carcinoma. Experimental cell research 11 34418457
2018 Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript. Molecular and cellular biology 11 29866654
2014 Specific enrichment of the RNA-binding proteins PCBP1 and PCBP2 in chief cells of the murine gastric mucosa. Gene expression patterns : GEP 11 24480778
2024 Role of PCBP2 in regulating nanovesicles loaded with curcumin to mitigate neuroferroptosis in neural damage caused by heat stroke. Journal of nanobiotechnology 10 39731111
2021 Knockdown of Splicing Complex Protein PCBP2 Reduces Extravillous Trophoblast Differentiation Through Transcript Switching. Frontiers in cell and developmental biology 10 34095140
2020 PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR. FEBS open bio 10 31961070
2020 Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone. Biochimica et biophysica acta. Molecular basis of disease 10 32480040
2020 Functional expression of ZNF467 and PCBP2 supports adipogenic lineage commitment in adipose-derived mesenchymal stem cells. Gene 9 32032745
2024 UKLF/PCBP2 axis governs the colorectal cancer development by transcriptionally activating SLC39A4. Biochimica et biophysica acta. Molecular cell research 8 38768927
2022 GPX2 stabilized by PCBP2 induces autophagy to protect Het-1A esophageal cells from apoptosis and inflammation. Cellular signalling 8 35798180
2021 Role of miR-490-3p in blocking bladder cancer growth through targeting the RNA-binding protein PCBP2. The Kaohsiung journal of medical sciences 8 34622526
2024 Circ_0005397 inhibits ferroptosis of pancreatic cancer cells by up-regulating PCBP2 through KAT6A/H3K9Ac. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 7 39235355
2023 MiR-5195-3p targets the PCBP2/PI3K/AKT pathway to inhibit melanoma cell proliferation and migration. Heliyon 7 37662755
2023 Bisphenol A exposure decreases sperm production and male fertility through inhibition PCBP2 expression. Environmental science and pollution research international 7 37985585
2021 PCBP2 Is Downregulated in Degenerating Neurons and Rarely Observed in TDP-43-Positive Inclusions in Sporadic Amyotrophic Lateral Sclerosis. Journal of neuropathology and experimental neurology 7 33313661
2015 Spatiotemporal Expression of Poly(rC)-Binding Protein PCBP2 Modulates Schwann Cell Proliferation After Sciatic Nerve Injury. Cellular and molecular neurobiology 7 26250704
2002 Complementary DNA analysis, expression and subcellular localization of hnRNP E2 gene in Xenopus laevis. Gene 7 12062814
2024 HNF4A-AS1 inhibits the progression of hepatocellular carcinoma by promoting the ubiquitin-modulated degradation of PCBP2 and suppressing the stability of ARG2 mRNA. International journal of biological sciences 6 39430249
2025 PCBP2-dependent secretion of miRNAs via extracellular vesicles contributes to the EGFR-driven angiogenesis. Theranostics 5 39816681
2025 PCBP2 promotes immune evasion via cGAS-STING pathway in biochemical recurrence of prostate cancer. APL bioengineering 5 40051782
2025 PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m6A Methylation to Stabilize PARP1 mRNA. Cancer research 5 40773674
2024 ELF5-Regulated lncRNA-TTN-AS1 Alleviates Myocardial Cell Injury via Recruiting PCBP2 to Increase CDK6 Stability in Myocardial Infarction. Molecular and cellular biology 5 39034459
2025 The binding of PCBP2 to IGF2 mRNA restores mitochondrial function in granulosa cells to ameliorate ovarian function in premature ovarian insufficiency mice. Cellular signalling 4 40886929
2025 LncRNA BASP1-AS1 drives PCBP2 K115 lactylation to suppress ferroptosis and confer oxaliplatin resistance in gastric cancer. Free radical biology & medicine 4 40914325
2022 The poly(C)-binding protein Pcbp2 is essential for CD4+ T cell activation and proliferation. iScience 4 36632062
2025 RNA binding proteins PCBP1 and PCBP2 regulate pancreatic β cell translation. Molecular metabolism 3 40451383
2025 Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading. eLife 3 40601477
2025 PCBP2 Promotes NRG4 mRNA Stability to Diminish Angiotensin II-Induced Hypertrophy, NLRP3 Inflammasome Activation, and Oxidative Stress of AC16 Cardiomyocytes. Cell biochemistry and biophysics 3 40679765
2024 Down-regulation of PCBP2 suppresses the invasion and migration of trophoblasts via the WNT5A/ROR2 pathway in preeclampsia†. Biology of reproduction 3 39115369
2025 PCBP2 as an intrinsic agi ng factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis. eLife 2 40053388
2025 PCBP2 in gastrointestinal cancers: fundamental mechanism and clinical potential. Journal of molecular medicine (Berlin, Germany) 2 40481884
2025 Pharmacologic inhibition of PCBP2 biomolecular condensates relieves Alzheimer's disease. Nature communications 2 41298370
2024 Duck hepatitis A virus utilizes PCBP2 to facilitate viral translation and replication. Veterinary research 2 39300570
2016 Identification of poly(rC) binding protein 2 (PCBP2) as a target protein of immunosuppressive agent 15-deoxyspergualin. Biochemical and biophysical research communications 2 27261432
2026 PCBP2 inhibits antiviral innate immune responses via the MAVS-mediated signaling pathway in severe fever with thrombocytopenia syndrome. Virus research 1 41638535
2025 PCBP2 alleviates myocardial infarction by inhibiting cardiomyocyte ferroptosis via the NDUFS1/NRF2 pathway. Molecular immunology 1 40784311
2025 Coexistence of G-Quadruplex and i-Motif Within a DNA Duplex is Tolerated by a PCBP2-Assisted Replisome. Angewandte Chemie (International ed. in English) 1 41327866
2025 ELK3-SERPINE1-PCBP2 axis promotes gefitinib resistance in lung cancer by inhibiting ferroptosis. International immunopharmacology 1 41380194
2024 PCBP2 stabilizes TROAP to promote the malignant progression of gastric cancer. Naunyn-Schmiedeberg's archives of pharmacology 1 39586843
2006 [Effect and possible mechanism of HnRNP E2 decoy RNA on proliferation of K562 leukemia cells]. Ai zheng = Aizheng = Chinese journal of cancer 1 16831266
2026 Impact of poly(rC)-binding protein 2 (PCBP2) on the malignant phenotype of cholangiocarcinoma. Biochemical pharmacology 0 41876016
2025 Fasting inhibits glycolysis and migration/invasion in gallbladder cancer via PCBP2/ANGPTL4 signaling. Cell cycle (Georgetown, Tex.) 0 40799165
2025 PCBP2 Regulates p16INK4a-Dependent Cellular Senescence in Response to Iron. Aging cell 0 41216990

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