Affinage

PAQR7

Membrane progestin receptor alpha · UniProt Q86WK9

Length
346 aa
Mass
39.7 kDa
Annotated
2026-06-10
100 papers in source corpus 12 papers cited in narrative 12 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PAQR7 (mPRα) is a membrane progesterone receptor that transduces rapid, non-genomic progesterone signaling through inhibitory G protein (Gi) coupling, with prominent roles in vascular smooth muscle relaxation, neural cell survival, and ovarian follicle development (PMID:29428395, PMID:36967764, PMID:38317224). In human vascular smooth muscle cells, progesterone acting through mPRα—but not the nuclear progesterone receptor—couples to Gi to lower cAMP, activate MAP kinase/ERK and Akt/PI3K signaling, and reduce myosin light chain phosphorylation, producing relaxation (PMID:29428395). This pathway lowers cytosolic Ca2+ by downregulating RhoA/ROCK activity (PMID:31416049) and by upregulating SERCA2 expression and phospholamban phosphorylation to drive Ca2+ uptake into the sarcoplasmic reticulum (PMID:33427050). Ligand recognition occurs through a zinc-containing pocket modeled on the adiponectin receptors, in which a hydrogen bond between Q206 and the progesterone 20-carbonyl is essential for binding; mutation of Q206 or V146 abolishes progesterone binding, and the AdipoR agonist AdipoRon mimics progesterone signaling at the receptor (PMID:35189329, PMID:35007844). Beyond the vasculature, mPRα mediates progesterone neuroprotection in dopaminergic cell models via PI3K-AKT and MAP kinase pathways (PMID:36967764), drives Schwann cell-like adipose stem cell migration, differentiation, and BDNF/IGF-2 release through Src and PI3K-Akt signaling to support neurite outgrowth and neuronal survival (PMID:33930460, PMID:35974286), and protects granulosa cells from apoptosis via BCL-2/BAX/CASPASE-3 signaling, with Paqr7 knockout mice showing impaired follicular growth, ovulation, and fertility (PMID:38317224).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2004 Low

    Before functional characterization, the question was whether PAQR7 (then PGLP) was a regulated gene of defined tissue context; it was placed downstream of PPARgamma1 as an inducible cytoplasmic membranous protein.

    Evidence Affymetrix microarray and adenoviral PPARgamma1 overexpression in mouse liver with cDNA cloning

    PMID:15589683

    Open questions at the time
    • No mechanistic function assigned to the protein
    • Link to progesterone signaling not yet established
    • Single transcriptional induction observation
  2. 2016 Medium

    To test whether PAQR-family membrane progesterone receptors are functionally required for reproduction, a tongue sole homolog was knocked down, establishing a role in progestin-induced oocyte maturation.

    Evidence Morpholino knockdown in fish oocytes with in situ hybridization and gonadotropin regulation analysis

    PMID:27554928

    Open questions at the time
    • Fish ortholog/paralog, not human PAQR7
    • Downstream signaling pathway not delineated
    • Receptor-ligand binding not directly shown
  3. 2018 High

    The central question of how progesterone produces rapid vascular effects was answered by showing mPRα couples to Gi to relax vascular smooth muscle independently of the nuclear receptor.

    Evidence Collagen gel and artery ring contraction assays, reciprocal mPRα vs nPR siRNA knockdown, pertussis toxin, and pathway inhibitors in human VSMCs

    PMID:29428395

    Open questions at the time
    • Direct receptor-G protein interaction not structurally resolved
    • In vivo vascular relevance not tested
  4. 2019 High

    Building on Gi coupling, the downstream effector arm was defined by showing mPRα lowers cytosolic Ca2+ through cAMP and MAPK/Akt downregulation and decreased RhoA/ROCK activity.

    Evidence Intracellular Ca2+ imaging, RhoA activity assay, siRNA knockdown, and pathway inhibitors in human umbilical artery VSMCs

    PMID:31416049

    Open questions at the time
    • Connection between RhoA downregulation and Ca2+ handling not fully resolved
    • Membrane proximal events between receptor and RhoA unmapped
  5. 2021 High

    The Ca2+-lowering mechanism was mechanistically completed by identifying SERCA2 upregulation and phospholamban phosphorylation as the effectors driving SR Ca2+ uptake and relaxation.

    Evidence SERCA2 siRNA knockdown, SERCA inhibitor CPA, SR Ca2+ measurement, and immunoblotting for PLB phosphorylation

    PMID:33427050

    Open questions at the time
    • Mechanism linking PI3K/Akt to PLB phosphorylation not defined
    • SERCA2 transcriptional vs post-translational induction not separated
  6. 2021 Medium

    To extend mPRα beyond vasculature, its activation in Schwann cell-like adipose stem cells was shown to promote migration, differentiation, and BDNF release via Src and PI3K-Akt.

    Evidence siRNA knockdown, selective agonist Org OD 02-0, migration assays, BDNF ELISA, and immunofluorescence localization

    PMID:33930460

    Open questions at the time
    • Mechanism of agonist-induced relocalization unknown
    • Direct Src activation by the receptor not shown
  7. 2022 Medium

    The molecular basis of ligand recognition was addressed by homology modeling and mutagenesis, defining a zinc-containing pocket and an essential Q206 hydrogen bond to progesterone.

    Evidence AdipoR1-based homology model, site-directed mutagenesis (Q206R, V146S), [3H]-progesterone radioligand binding, and AdipoRon/D-e-MAPP pharmacology

    PMID:35189329

    Open questions at the time
    • No experimental structure of PAQR7
    • Single lab; model-based predictions
    • Zinc stoichiometry and catalytic relevance not established
  8. 2022 Medium

    Direct ligand binding was independently confirmed using a graphene quantum dot-conjugated receptor assay showing competitive progesterone binding.

    Evidence Fluorescence-based competitive binding with GQD-mPRα and progesterone-BSA-FITC

    PMID:35007844

    Open questions at the time
    • Single method, single lab
    • Binding affinity and kinetics not quantified
  9. 2022 Medium

    The neural role was broadened by showing mPRα-activated SCL-ASCs promote neurite outgrowth in neurons via secreted BDNF and IGF-2, while direct neuronal mPRα activation promotes survival.

    Evidence Conditioned medium, co-culture, siRNA knockdown in SCL-ASC, selective agonist, and BDNF/IGF-2 measurement

    PMID:35974286

    Open questions at the time
    • Paracrine vs direct contributions in vivo unquantified
    • Signaling linking mPRα to BDNF/IGF-2 secretion not mapped
  10. 2023 Medium

    Whether mPRα mediates progesterone neuroprotection was tested in a Parkinson's disease cell model, showing selective mPR agonism protects against neurotoxins via PI3K-AKT and MAP kinase.

    Evidence siRNA knockdown, selective agonist Org OD 02-0 vs R5020 vs muscimol, viability assays, and pathway inhibitors in SH-SY5Y cells

    PMID:36967764

    Open questions at the time
    • No in vivo neuroprotection demonstrated
    • Downstream survival effectors not identified
  11. 2024 Medium

    The reproductive requirement for PAQR7 in mammals was established, linking its anti-apoptotic BCL-2/BAX/CASPASE-3 signaling to follicle development and fertility.

    Evidence siPAQR7 in KGN granulosa cells with P4 rescue, Paqr7 knockout mice, follicle counts, hormone measurements, and apoptosis pathway western blots

    PMID:38317224

    Open questions at the time
    • Coupling between receptor and BCL-2/BAX regulation not delineated
    • Single lab; granulosa-specific vs systemic contributions not separated
  12. 2025 Low

    Pharmacological tractability of the ligand pocket was probed by identifying 2-HPA as a competitive natural antagonist with structural specificity.

    Evidence GQD-mPRα competitive binding assay, goldfish oocyte maturation, and zebrafish ovulation assays

    PMID:39922053

    Open questions at the time
    • Single lab, single paper
    • Antagonism validated in fish, not human cells
    • No structural confirmation of binding site engagement

Open questions

Synthesis pass · forward-looking unresolved questions
  • How mPRα physically engages Gi at the membrane and how a single receptor selects between vascular relaxation, neuroprotective, and anti-apoptotic outputs in different cell types remains unresolved.
  • No experimental receptor structure or receptor-G protein complex
  • Cell-type-specific effector selection unexplained
  • In vivo vascular and neural functions largely untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 2 GO:0060089 molecular transducer activity 2
Localization
GO:0005886 plasma membrane 2 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1474165 Reproduction 2 R-HSA-5357801 Programmed Cell Death 1

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2018 PAQR7 (mPRα) mediates rapid progesterone-induced relaxation of human umbilical vein vascular smooth muscle cells (VSMCs) through Gi protein coupling, leading to decreased cAMP, activation of MAP kinase/ERK and Akt/PI3K pathways, and reduced myosin light chain phosphorylation. These effects were blocked by pertussis toxin, mPRα siRNA knockdown, and pathway-specific inhibitors, but not by nuclear PR agonist R5020 or nPR siRNA. Collagen gel disk contraction assay, endothelium-denuded artery ring tension assay, siRNA knockdown, pertussis toxin treatment, pharmacological inhibitors (AZD6244, wortmannin, 8-Br-cAMP) Molecular and cellular endocrinology High 29428395
2019 mPRα (PAQR7) mediates progesterone-induced decrease in cytosolic Ca2+ in human umbilical artery VSMCs via Gi protein activation, downregulation of cAMP, inhibition of MAPK/Akt signaling, and decreased RhoA/ROCK activity. Knockdown of mPRα (but not nuclear PR) abolished these effects; pertussis toxin, 8-Br-cAMP, MAPK inhibitor PD98059, and Akt inhibitor ML-9 all blocked progesterone-induced Ca2+ decrease and VSMC relaxation. Intracellular Ca2+ measurement, siRNA knockdown, pertussis toxin treatment, pharmacological inhibitors, RhoA activity assay Journal of molecular endocrinology High 31416049
2021 mPRα (PAQR7)-mediated progesterone signaling in VSMCs involves upregulation of SERCA2 protein expression and phospholamban (PLB) phosphorylation (disinhibiting SERCA), leading to increased Ca2+ uptake into the SR and VSMC relaxation. These effects required Gi, MAP kinase, Akt/PI3K signaling, and RhoA downregulation; SERCA2 siRNA knockdown or CPA (SERCA inhibitor) blocked progesterone-induced relaxation. SERCA2 siRNA knockdown, pharmacological inhibitors (CPA, NF023, AZD6244, wortmannin, calpeptin), SR Ca2+ measurement, immunoblotting for PLB phosphorylation American journal of physiology. Endocrinology and metabolism High 33427050
2022 Homology modeling of mPRα (PAQR7) based on AdipoR1 crystal structure revealed: (1) intracellular N-terminus membrane orientation; (2) a zinc-binding pocket homologous to AdipoRs; (3) a critical H-bond between Q206 and the 20-carbonyl of progesterone. Mutational analysis showed complete loss of [3H]-progesterone binding in Q206R and V146S mutants. High Zn2+ concentrations restored progesterone binding in Q206R mutant, consistent with competitive displacement of oleic acid from the binding pocket. AdipoRon bound mPRα and mimicked progesterone signaling; D-e-MAPP blocked progesterone signaling. Homology modeling (AdipoR1 X-ray as template), site-directed mutagenesis, [3H]-progesterone radioligand binding assay, pharmacological assays The Journal of steroid biochemistry and molecular biology Medium 35189329
2022 A steroid binding assay using graphene quantum dot-conjugated mPRα (GQD-mPRα) demonstrated direct ligand-receptor binding between mPRα and progesterone-BSA-FITC, with competition by free progesterone, confirming mPRα has a functional progesterone binding site. Fluorescence-based competitive binding assay using GQD-conjugated mPRα protein and progesterone-BSA-FITC Biochemical and biophysical research communications Medium 35007844
2023 mPRα (PAQR7) mediates neuroprotective effects of progesterone against 6-OHDA and MPP+ toxicity in SH-SY5Y cells (Parkinson's disease model). The mPR-selective agonist Org OD 02-0 was effective while nuclear PR agonist R5020 and GABAA agonist muscimol were not. mPRα siRNA knockdown abolished neuroprotection. PI3K-AKT and MAP kinase signaling pathways are involved in mPRα-mediated neuroprotection. siRNA knockdown of mPRα isoforms, selective pharmacological agonists (Org OD 02-0 vs R5020 vs muscimol), cell viability assays, pathway inhibitors Frontiers in endocrinology Medium 36967764
2021 mPRα (PAQR7) activation in Schwann cell-like adipose stem cells (SCL-ASC) promotes cell migration, differentiation, morphology changes, and BDNF release. mPRα localization changed upon activation. Src and PI3K-Akt signaling pathways are required for mPRα activity in SCL-ASC. mPRα siRNA confirmed this isoform is responsible. siRNA knockdown of mPRα, selective mPR agonist Org OD 02-0, cell migration assays, BDNF ELISA, pathway inhibitors, immunofluorescence for localization Molecular and cellular endocrinology Medium 33930460
2022 mPRα (PAQR7) activation in Schwann cell-like adipose stem cells (SCL-ASC) promotes neurite outgrowth in co-cultured neuronal cells (IMR-32 and SH-SY5Y) through SCL-ASC-dependent release of BDNF and IGF-2, while direct mPRα activation on neuronal cells promotes cell survival. mPRα siRNA in SCL-ASC abolished the neurite outgrowth effect. Conditioned medium experiments, co-culture, siRNA knockdown of mPRα in SCL-ASC, selective agonist Org OD 02-0, BDNF/IGF-2 measurements Journal of molecular neuroscience : MN Medium 35974286
2024 PAQR7 deficiency in KGN granulosa cells increased apoptosis, which was rescued by P4 supplementation. Paqr7 knockout female mice showed prolonged estrous cycles, reduced follicular growth, increased atresia follicles, decreased E2 and AMH, reduced litter sizes, and impaired spontaneous ovulation. The anti-apoptotic mechanism involves the BCL-2/BAX/CASPASE-3 signaling pathway. siPAQR7 knockdown in KGN cells, Paqr7 knockout mouse model, follicle counting, hormone measurements, apoptosis assays, western blot for BCL-2/BAX/CASPASE-3 Journal of ovarian research Medium 38317224
2016 A Paqr7 structural homolog (Paqr7b) in half-smooth tongue sole fish ovary is required for progestin-induced oocyte maturation. Morpholino antisense knockdown of Paqr7b in oocytes blocked progestin-induced maturation. Paqr7b expression in oocytes and pituitary was regulated by gonadotropin in a dose- and stage-dependent manner. Morpholino antisense oligonucleotide microinjection in oocytes, in situ hybridization, immunohistochemistry, cDNA cloning and phylogenetic analysis General and comparative endocrinology Medium 27554928
2025 2-Hydroxypentanoic acid (2-HPA) from marine algae Padina shows competitive binding to human mPRα (PAQR7) in a GQD-mPRα binding assay and inhibits fish oocyte maturation and ovulation in vivo. Both S- and R-stereoisomers showed equal activity. Structural analogues of 2-HPA lacked competitive binding, indicating structural specificity. 2-HPA acts as a novel mPRα antagonist. GQD-mPRα competitive binding assay, goldfish oocyte maturation assay in vitro, zebrafish ovulation assay in vivo Biochemical and biophysical research communications Low 39922053
2004 PGLP (an alias for PAQR7) was identified as a PPARgamma1-target gene encoding a 38 kDa cytoplasmic membranous protein that is dramatically induced in mouse liver following PPARgamma1 overexpression (adenoviral approach) but not by fasting or choline deficiency-induced fatty liver. Full-length cDNA was cloned. Affymetrix microarray, adenoviral PPARgamma1 overexpression in PPARalpha-deficient mouse liver, cDNA cloning, northern blot Biochimie Low 15589683

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 Metabolic characterisation of Magnetospirillum gryphiswaldense MSR-1 using LC-MS-based metabolite profiling. RSC advances 113 35516490
1996 Expression of a new G protein-coupled receptor X-msr is associated with an endothelial lineage in Xenopus laevis. Mechanisms of development 110 8951791
1999 Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ. Mechanisms of development 109 10473142
2004 Characterization and prevalence of MefA, MefE, and the associated msr(D) gene in Streptococcus pneumoniae clinical isolates. Journal of clinical microbiology 90 15297499
2002 Expression of the murine msr/apj receptor and its ligand apelin is upregulated during formation of the retinal vessels. Mechanisms of development 81 11744380
2003 Msr(A) and related macrolide/streptogramin resistance determinants: incomplete transporters? International journal of antimicrobial agents 80 13678826
2000 Dissociation of the high density lipoprotein and low density lipoprotein binding activities of murine scavenger receptor class B type I (mSR-BI) using retrovirus library-based activity dissection. The Journal of biological chemistry 79 10734045
2007 Purified and sterilized magnetosomes from Magnetospirillum gryphiswaldense MSR-1 were not toxic to mouse fibroblasts in vitro. Letters in applied microbiology 69 17594464
2004 The PmlI-PmlR quorum-sensing system in Burkholderia pseudomallei plays a key role in virulence and modulates production of the MprA protease. Journal of bacteriology 68 15060030
2005 Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA. Journal of bacteriology 65 15601704
2008 Ferrous iron transport protein B gene (feoB1) plays an accessory role in magnetosome formation in Magnetospirillum gryphiswaldense strain MSR-1. Research in microbiology 63 18639631
2003 Characteristic expression of three genes, msr(A), mph(C) and erm(Y), that confer resistance to macrolide antibiotics on Staphylococcus aureus. FEMS microbiology letters 59 12670694
2011 Semicontinuous culture of Magnetospirillum gryphiswaldense MSR-1 cells in an autofermentor by nutrient-balanced and isosmotic feeding strategies. Applied and environmental microbiology 58 21724877
2003 The msr/apj gene encoding the apelin receptor is an early and specific marker of the venous phenotype in the retinal vasculature. Gene expression patterns : GEP 58 12915314
2008 High-yield growth and magnetosome formation by Magnetospirillum gryphiswaldense MSR-1 in an oxygen-controlled fermentor supplied solely with air. Applied microbiology and biotechnology 56 18425510
2011 Components of the Rv0081-Rv0088 locus, which encodes a predicted formate hydrogenlyase complex, are coregulated by Rv0081, MprA, and DosR in Mycobacterium tuberculosis. Journal of bacteriology 49 21821774
1997 The multiple roles of macrophage scavenger receptors (MSR) in vivo: resistance to atherosclerosis and susceptibility to infection in MSR knockout mice. Journal of atherosclerosis and thrombosis 42 9583348
2012 FeoB2 Functions in magnetosome formation and oxidative stress protection in Magnetospirillum gryphiswaldense strain MSR-1. Journal of bacteriology 40 22636767
1990 mprA, an Escherichia coli gene that reduces growth-phase-dependent synthesis of microcins B17 and C7 and blocks osmoinduction of proU when cloned on a high-copy-number plasmid. Journal of bacteriology 40 2152912
1991 Nucleotide sequence of the Escherichia coli regulatory gene mprA and construction and characterization of mprA-deficient mutants. Journal of bacteriology 39 1840583
2001 Uptake of fibrillar beta-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice. Neuroreport 38 11338182
2014 Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes. Frontiers in microbiology 37 25538698
2006 Staphylococcus efflux msr(A) gene characterized in Streptococcus, Enterococcus, Corynebacterium, and Pseudomonas isolates. Antimicrobial agents and chemotherapy 36 16495276
2015 Transcriptional attenuation controls macrolide inducible efflux and resistance in Streptococcus pneumoniae and in other Gram-positive bacteria containing mef/mel(msr(D)) elements. PloS one 35 25695510
2012 Functional interplay between the ATP binding cassette Msr(D) protein and the membrane facilitator superfamily Mef(E) transporter for macrolide resistance in Escherichia coli. Research in microbiology 33 23261969
2021 Effects of Long-Term Exposure to Copper on the Keap1/Nrf2 Signaling Pathway and Msr-Related Redox Status in the Kidneys of Rats. Biological trace element research 31 33479888
2019 Optimized PCR conditions minimizing the formation of chimeric DNA molecules from MPRA plasmid libraries. BMC genomics 31 31291895
2015 Predominant role of msr(D) over mef(A) in macrolide resistance in Streptococcus pyogenes. Microbiology (Reading, England) 30 26531240
2023 Role of Oxidative Stress, Methionine Oxidation and Methionine Sulfoxide Reductases (MSR) in Alzheimer's Disease. Antioxidants (Basel, Switzerland) 29 38275641
2010 mamO and mamE genes are essential for magnetosome crystal biomineralization in Magnetospirillum gryphiswaldense MSR-1. Research in microbiology 29 20674739
2004 Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. Biochimie 28 15589683
2013 Regulation of MSR-1 and CD36 in macrophages by LOX-1 mediated through PPAR-γ. Biochemical and biophysical research communications 27 23333385
2018 QuASAR-MPRA: accurate allele-specific analysis for massively parallel reporter assays. Bioinformatics (Oxford, England) 26 29028988
2019 Methionine sulfoxide reductase (Msr) dysfunction in human brain disease. Free radical research 23 31775527
2018 Progesterone induces relaxation of human umbilical cord vascular smooth muscle cells through mPRα (PAQR7). Molecular and cellular endocrinology 21 29428395
2018 Development of a simple intensified fermentation strategy for growth of Magnetospirillum gryphiswaldense MSR-1: Physiological responses to changing environmental conditions. New biotechnology 21 29864580
2006 Molecular epidemiology of macrolide resistance in beta-haemolytic streptococci of Lancefield groups A, B, C and G and evidence for a new mef element in group G streptococci that carries allelic variants of mef and msr(D). The Journal of antimicrobial chemotherapy 21 16431859
2022 Molecular modeling, mutational analysis and steroid specificity of the ligand binding pocket of mPRα (PAQR7): Shared ligand binding with AdipoR1 and its structural basis. The Journal of steroid biochemistry and molecular biology 19 35189329
2021 Involvement of sarco/endoplasmic reticulum Ca2-ATPase (SERCA) in mPRα (PAQR7)-mediated progesterone induction of vascular smooth muscle relaxation. American journal of physiology. Endocrinology and metabolism 19 33427050
2013 Expression patterns of key iron and oxygen metabolism genes during magnetosome formation in Magnetospirillum gryphiswaldense MSR-1. FEMS microbiology letters 19 23937222
2019 Role of mPRα (PAQR7) in progesterone-induced Ca2+ decrease in human vascular smooth muscle cells. Journal of molecular endocrinology 18 31416049
2024 Characterization of enhancer activity in early human neurodevelopment using Massively Parallel Reporter Assay (MPRA) and forebrain organoids. Scientific reports 17 38365907
2018 Functional Predominance of msr(D), Which Is More Effective as mef(A)-Associated Than mef(E)-Associated, Over mef(A)/mef(E) in Macrolide Resistance in Streptococcus pyogenes. Microbial drug resistance (Larchmont, N.Y.) 17 29406792
2017 Physiological characteristics of Magnetospirillum gryphiswaldense MSR-1 that control cell growth under high-iron and low-oxygen conditions. Scientific reports 17 28584275
2016 Transcriptome analysis reveals physiological characteristics required for magnetosome formation in Magnetospirillum gryphiswaldense MSR-1. Environmental microbiology reports 17 27043321
2015 Iron response regulator protein IrrB in Magnetospirillum gryphiswaldense MSR-1 helps control the iron/oxygen balance, oxidative stress tolerance, and magnetosome formation. Applied and environmental microbiology 17 26386052
2022 Time-Sensitive Aspects of Mars Sample Return (MSR) Science. Astrobiology 16 34904889
2013 MamX encoded by the mamXY operon is involved in control of magnetosome maturation in Magnetospirillum gryphiswaldense MSR-1. BMC microbiology 16 24020498
2012 Two bifunctional enzymes with ferric reduction ability play complementary roles during magnetosome synthesis in Magnetospirillum gryphiswaldense MSR-1. Journal of bacteriology 16 23243303
2023 Progesterone exerts a neuroprotective action in a Parkinson's disease human cell model through membrane progesterone receptor α (mPRα/PAQR7). Frontiers in endocrinology 15 36967764
2021 Fusion expression of nanobodies specific for the insecticide fipronil on magnetosomes in Magnetospirillum gryphiswaldense MSR-1. Journal of nanobiotechnology 15 33468141
2007 A novel ferric reductase purified from Magnetospirillum gryphiswaldense MSR-1. Current microbiology 15 17534559
1995 Developmental and pathogen-induced activation of an msr gene, str 246C, from tobacco involves multiple regulatory elements. Molecular & general genetics : MGG 15 7770037
2022 MSR-RCNN: A Multi-Class Crop Pest Detection Network Based on a Multi-Scale Super-Resolution Feature Enhancement Module. Frontiers in plant science 14 35310676
2021 Membrane progesterone receptor α (mPRα/PAQR7) promotes migration, proliferation and BDNF release in human Schwann cell-like differentiated adipose stem cells. Molecular and cellular endocrinology 14 33930460
2020 The Novel Macrolide Resistance Genes mef(D), msr(F), and msr(H) Are Present on Resistance Islands in Macrococcus canis, Macrococcus caseolyticus, and Staphylococcus aureus. Antimicrobial agents and chemotherapy 14 32122903
2017 PGLP-1, a novel long-acting dual-function GLP-1 analog, ameliorates streptozotocin-induced hyperglycemia and inhibits body weight loss. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 14 28461341
2007 Development and clinical evaluation of a PCR assay targeting the metalloprotease gene (mprA) of B. pseudomallei. Zoonoses and public health 14 17359446
2012 Crystallization and preliminary crystallographic analysis of the C-terminal domain of MamM, a magnetosome-associated protein from Magnetospirillum gryphiswaldense MSR-1. Acta crystallographica. Section F, Structural biology and crystallization communications 13 22869124
2007 Disruption of a fur-like gene inhibits magnetosome formation in Magnetospirillum gryphiswaldense MSR-1. Biochemistry. Biokhimiia 13 18205608
2022 circRNA-MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR-761 in osteoarthritis. The Kaohsiung journal of medical sciences 12 36278814
2021 PAQR7: An intermediary mediating nongenomic progesterone action in female reproductive tissue. Reproductive biology 12 34217103
2021 A comprehensive assessment of the biocompatibility of Magnetospirillum gryphiswaldense MSR-1 bacterial magnetosomes in vitro and in vivo. Toxicology 12 34534559
2022 Planning Implications Related to Sterilization-Sensitive Science Investigations Associated with Mars Sample Return (MSR). Astrobiology 11 34904892
2022 Establishment of a steroid binding assay for membrane progesterone receptor alpha (PAQR7) by using graphene quantum dots (GQDs). Biochemical and biophysical research communications 11 35007844
2021 CircRNA-MSR Regulates LPS-Induced C28/I2 Chondrocyte Injury through miR-643/MAP2K6 Signaling Pathway. Cartilage 11 34581623
2021 Predicted transmembrane proteins with homology to Mef(A) are not responsible for complementing mef(A) deletion in the mef(A)-msr(D) macrolide efflux system in Streptococcus pneumoniae. BMC research notes 10 34823574
2023 Genome-Wide Identification and Characterization of the Msr Gene Family in Alfalfa under Abiotic Stress. International journal of molecular sciences 9 37298589
2023 Biosynthesis of magnetosome-nanobody complex in Magnetospirillum gryphiswaldense MSR-1 and a magnetosome-nanobody-based enzyme-linked immunosorbent assay for the detection of tetrabromobisphenol A in water. Analytical and bioanalytical chemistry 9 37934249
2023 Pan msr gene deleted strain of Salmonella Typhimurium suffers oxidative stress, depicts macromolecular damage and attenuated virulence. Scientific reports 9 38071209
2019 Effects of Environmental Conditions on High-Yield Magnetosome Production by Magnetospirillum gryphiswaldense MSR-1. Iranian biomedical journal 9 30797225
2018 Design tools for MPRA experiments. Bioinformatics (Oxford, England) 9 30052913
2016 Identification and characterization of a progestin and adipoQ receptor (PAQR) structurally related to Paqr7 in the ovary of Cynoglossus semilaevis and its potential role in regulating oocyte maturation. General and comparative endocrinology 9 27554928
2015 Correlation between genetic features of the mef(A)-msr(D) locus and erythromycin resistance in Streptococcus pyogenes. Diagnostic microbiology and infectious disease 9 26429294
2022 Relevance of methionine sulfoxide reductase(s) (MSR) as candidate proteins in redox homeostasis-mediated resistance response to Helicoverpa armigera (Hübner) in the pigeonpea wild relative Cajanus platycarpus (Benth.) Maesen. International journal of biological macromolecules 8 35718158
2007 A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case-control study. Clinical biochemistry 8 17553479
2017 The Disruption of an OxyR-Like Protein Impairs Intracellular Magnetite Biomineralization in Magnetospirillum gryphiswaldense MSR-1. Frontiers in microbiology 7 28261169
2016 A novel role for Crp in controlling magnetosome biosynthesis in Magnetospirillum gryphiswaldense MSR-1. Scientific reports 7 26879571
2024 Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice. Journal of ovarian research 6 38317224
2023 Streptococcus pyogenes Φ1207.3 Is a Temperate Bacteriophage Carrying the Macrolide Resistance Gene Pair mef(A)-msr(D) and Capable of Lysogenizing Different Streptococci. Microbiology spectrum 6 36625667
2015 ClpP-independent function of ClpX interferes with telithromycin resistance conferred by Msr(A) in Staphylococcus aureus. Antimicrobial agents and chemotherapy 6 25801573
2009 A thiol-activated lipase from Trichosporon asahii MSR 54: detergent compatibility and presoak formulation for oil removal from soiled cloth at ambient temperature. Journal of industrial microbiology & biotechnology 6 19165516
2008 [Using MSR model to analyze the impact of gene-gene interaction with related to the genetic polymorphism of metabolism enzymes on the risk of breast cancer]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 6 19024313
2023 Hexavalent chromate bioreduction by a magnetotactic bacterium Magnetospirillum gryphiswaldense MSR-1 and the effect of magnetosome synthesis. Chemosphere 5 37088211
2023 Evaluation of cell disruption technologies on magnetosome chain length and aggregation behaviour from Magnetospirillum gryphiswaldense MSR-1. Frontiers in bioengineering and biotechnology 5 37214292
2023 Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids. bioRxiv : the preprint server for biology 5 37645832
2022 Macrolides mediate transcriptional activation of the msr(E)-mph(E) operon through histone-like nucleoid-structuring protein (HNS) and cAMP receptor protein (CRP). The Journal of antimicrobial chemotherapy 5 34747464
2021 The novel macrolide resistance genes mef(F) and msr(G) are located on a plasmid in Macrococcus canis and a transposon in Macrococcus caseolyticus. The Journal of antimicrobial chemotherapy 5 33118027
2021 Continuous stimulation of dual-function peptide PGLP-1-VP inhibits the morbidity and mortality of NOD mice through anti-inflammation and immunoregulation. Scientific reports 5 33574570
2022 Successful Intra- but Not Inter-species Recombination of msr(D) in Neisseria subflava. Frontiers in microbiology 4 35432273
2022 Methionine strengthens anti-inflammation of rice protein via depressing NF-κB activation and stimulating Msr expression in rats fed cholesterol-enriched diets. Food science and biotechnology 4 35646410
2019 Work Patterns of MamXY Proteins during Magnetosome Formation in Magnetospirillum gryphiswaldense MSR-1. Applied and environmental microbiology 4 30367002
2019 Novel Protein Mg2046 Regulates Magnetosome Synthesis in Magnetospirillum gryphiswaldense MSR-1 by Modulating a Proper Redox Status. Frontiers in microbiology 4 31297108
2025 Discovery of specific activity of 2-hydroxypentanoic acid acting on the mPR alpha (Paqr7) from the marine algae Padina. Biochemical and biophysical research communications 3 39922053
2024 Assessing the effects of NapA gene overexpression on denitrification and denitrogenation in magnetospirillum gryphiswaldense MSR-1. Archives of microbiology 3 39425777
2024 Bioinformatics of simultaneous, quantitative measurements of full-length tRNA and tRNA fragments by MSR sequencing. Methods in enzymology 3 39952712
2022 Membrane Progesterone Receptor α (mPRα/PAQR7) Promotes Survival and Neurite Outgrowth of Human Neuronal Cells by a Direct Action and Through Schwann Cell-like Stem Cells. Journal of molecular neuroscience : MN 3 35974286
2021 OxyR-Like Improves Cell Hydrogen Peroxide Tolerance by Participating in Monocyte Chemotaxis and Oxidative Phosphorylation Regulation in Magnetospirillum Gryphiswaldense MSR-1. Journal of biomedical nanotechnology 3 34974869
2018 Novel MprA binding motifs in the phoP regulatory region in Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland) 3 30205970
2010 Crystallization and preliminary crystallographic analysis of the Magnetospirillum magneticum AMB-1 and M. gryphiswaldense MSR-1 magnetosome-associated proteins MamA. Acta crystallographica. Section F, Structural biology and crystallization communications 3 20606283

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