Affinage

PAQR7

Membrane progestin receptor alpha · UniProt Q86WK9

Length
346 aa
Mass
39.7 kDa
Annotated
2026-04-29
100 papers in source corpus 10 papers cited in narrative 10 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PAQR7 (mPRα) is a membrane progesterone receptor that mediates rapid, nongenomic progesterone signaling across multiple cell types including vascular smooth muscle, neural cells, and ovarian granulosa cells. Structurally homologous to adiponectin receptors, it adopts a 7-transmembrane topology with an intracellular N-terminus and a zinc-containing ligand-binding pocket in which residues Q206 and V146 are critical for progesterone binding (PMID:35189329). Upon ligand engagement, PAQR7 couples to inhibitory G proteins (Gi) to suppress cAMP, activate ERK and PI3K-Akt signaling, reduce RhoA/ROCK activity, increase SERCA2-mediated sarcoplasmic reticulum Ca²⁺ uptake, and decrease myosin light chain phosphorylation, collectively mediating vascular smooth muscle relaxation (PMID:29428395, PMID:31416049, PMID:33427050). PAQR7 also promotes neuroprotection via PI3K-Akt and MAPK pathways, drives Schwann cell-like differentiation and BDNF release through Src and PI3K-Akt signaling, regulates oocyte maturation, and is required for normal ovarian follicle development and granulosa cell survival through BCL-2/BAX/CASPASE-3 signaling, as demonstrated by increased apoptosis and reduced fertility in Paqr7 knockout mice (PMID:36967764, PMID:33930460, PMID:38317224, PMID:27554928).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2016 Medium

    Establishing that PAQR7-family receptors function as membrane mediators of progestin-induced oocyte maturation resolved whether nongenomic progesterone signaling at the oocyte surface requires this receptor class.

    Evidence Morpholino antisense knockdown of Paqr7b in tongue sole oocytes blocked progestin-induced maturation

    PMID:27554928

    Open questions at the time
    • Fish ortholog; relevance to mammalian oocyte maturation not directly tested
    • Downstream signaling intermediates not characterized in this system
  2. 2018 High

    Demonstrating that PAQR7 mediates progesterone-induced vascular smooth muscle relaxation through Gi-coupled cAMP suppression, ERK/Akt activation, and reduced myosin light chain phosphorylation established a complete nongenomic signaling cascade from receptor to contractile function, independent of nuclear progesterone receptors.

    Evidence siRNA knockdown, pertussis toxin, selective agonist/antagonist controls, collagen gel contraction and artery ring tension assays in human VSMCs and umbilical arteries

    PMID:29428395

    Open questions at the time
    • In vivo cardiovascular relevance not established
    • Identity of the specific Gi subunit(s) not determined
  3. 2019 High

    Identifying that PAQR7-mediated signaling converges on cytosolic Ca²⁺ reduction via RhoA/ROCK inhibition and L-type Ca²⁺ channel regulation revealed the ionic mechanism underlying VSMC relaxation downstream of Gi activation.

    Evidence Ca²⁺ imaging, siRNA knockdown, pertussis toxin, pharmacological inhibitors (PD98059, ML-9, calpeptin), and Ca²⁺ channel activator FPL64176 in human VSMCs

    PMID:31416049

    Open questions at the time
    • Direct interaction between PAQR7 and RhoA/ROCK components not shown
    • Contribution of store-operated Ca²⁺ entry not addressed
  4. 2021 High

    Showing that PAQR7 upregulates SERCA2 expression and phospholamban phosphorylation to enhance SR Ca²⁺ sequestration identified the intracellular Ca²⁺ store as a critical effector compartment and unified the cAMP, MAPK, Akt, and RhoA signaling branches into a single vasorelaxation model.

    Evidence Dual siRNA knockdown (mPRα and SERCA2), SERCA inhibitor cyclopiazonic acid, protein expression and phosphorylation assays in human VSMCs

    PMID:33427050

    Open questions at the time
    • Transcriptional versus post-translational mechanism of SERCA2 upregulation not distinguished
    • Relevance to non-vascular smooth muscle types unknown
  5. 2021 Medium

    Extending PAQR7 function beyond vasorelaxation, demonstration that it promotes migration, differentiation, and BDNF release in Schwann cell-like adipose stem cells through Src and PI3K-Akt signaling broadened the receptor's physiological scope to neural repair.

    Evidence siRNA knockdown, selective mPRα agonist, migration assay, BDNF ELISA, immunofluorescence in differentiated adipose stem cells

    PMID:33930460

    Open questions at the time
    • In vivo nerve regeneration not tested
    • Src as direct PAQR7 effector versus indirect downstream mediator not resolved
  6. 2022 High

    Homology modeling based on AdipoR structures combined with mutagenesis identified the zinc-containing binding pocket topology and pinpointed Q206 and V146 as essential progesterone-contact residues, providing the first structural framework for PAQR7 ligand recognition.

    Evidence AdipoR-based homology modeling, site-directed mutagenesis (Q206R, V146S), [³H]-progesterone radioligand binding, Zn²⁺ rescue experiments

    PMID:35189329

    Open questions at the time
    • No experimental 3D structure (crystallography/cryo-EM)
    • Mechanism by which Zn²⁺ displaces oleic acid to restore binding is inferred, not directly visualized
  7. 2022 Medium

    Development of a graphene quantum dot (GQD)-conjugated mPRα binding assay provided an independent biophysical confirmation of direct progesterone–PAQR7 interaction and a platform for antagonist screening.

    Evidence GQD-mPRα fluorescence binding assay with competitive displacement by free progesterone

    PMID:35007844

    Open questions at the time
    • Binding affinity kinetics (Kd, kon/koff) not quantified
    • Assay validated only with progesterone; broader steroid selectivity profile incomplete
  8. 2023 Medium

    Demonstrating that PAQR7 mediates progesterone neuroprotection against dopaminergic neurotoxins via PI3K-Akt and MAPK extended the receptor's cytoprotective role to a Parkinson's disease-relevant context, independent of nuclear PR and GABAA receptors.

    Evidence siRNA knockdown, selective mPRα agonist Org OD 02-0, pathway inhibitors, cell viability assays in 6-OHDA/MPP+-treated SH-SY5Y cells

    PMID:36967764

    Open questions at the time
    • No in vivo PD model tested
    • Anti-apoptotic versus pro-survival signaling nodes not dissected
  9. 2024 Medium

    Paqr7 knockout mice exhibiting increased granulosa cell apoptosis, follicular atresia, and reduced fertility established PAQR7 as essential for ovarian function and identified BCL-2/BAX/CASPASE-3 as the downstream apoptotic pathway.

    Evidence PAQR7 knockout mice (follicle counts, hormone measurements, litter size), siRNA in human KGN cells with progesterone rescue, apoptosis assays

    PMID:38317224

    Open questions at the time
    • Contribution of other mPR subtypes (mPRβ, mPRγ) to ovarian function not controlled
    • Whether the fertility defect is solely ovarian or also involves uterine receptivity not addressed
  10. 2025 Medium

    Identification of 2-hydroxypentanoic acid as a competitive PAQR7 antagonist that blocks oocyte maturation and ovulation in vivo provided the first pharmacological tool compound to dissect receptor function in reproductive physiology.

    Evidence GQD-mPRα competitive binding assay, goldfish oocyte maturation assay, zebrafish in vivo ovulation assay, inactive structural analogues as controls

    PMID:39922053

    Open questions at the time
    • Selectivity for mPRα over other PAQR family members not fully profiled
    • Mammalian in vivo antagonist activity not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • An experimental high-resolution structure of PAQR7, the identity of the specific Gαi subunit it engages, the mechanism linking receptor activation to Src recruitment, and whether PAQR7 functions as a monomer or oligomer all remain unresolved.
  • No cryo-EM or crystal structure
  • Direct G protein coupling interface not mapped
  • Oligomeric state unknown
  • Relative contributions of mPRα versus mPRβ/γ in shared tissues not systematically compared

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 5 GO:0098772 molecular function regulator activity 3
Localization
GO:0005886 plasma membrane 5
Pathway
R-HSA-1474165 Reproduction 3 R-HSA-5357801 Programmed Cell Death 2
Partners
GNAIPLBRHOASERCA2SRC

Evidence

Reading pass · 10 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2018 PAQR7 (mPRα) mediates progesterone-induced relaxation of human vascular smooth muscle cells (VSMCs) through Gi protein activation, leading to decreased cAMP, increased ERK and Akt phosphorylation, and reduced myosin light chain phosphorylation; these effects were blocked by pertussis toxin, mPRα siRNA, MAP kinase inhibitor (AZD6244), and PI3K inhibitor (wortmannin), but not by nuclear PR siRNA or the nPR agonist R5020. siRNA knockdown, collagen gel disk contraction assay, umbilical artery ring tension assay, pertussis toxin treatment, pharmacological inhibitors Molecular and cellular endocrinology High 29428395
2019 PAQR7 (mPRα) mediates progesterone-induced decrease in cytosolic Ca2+ in human VSMCs via Gi signaling, downregulation of cAMP, inhibition of MAPK/Akt pathways, and reduction of RhoA/ROCK signaling; knockdown of mPRα but not nuclear PR blocked these effects, and Ca2+ channel activator FPL64176 abolished VSMC relaxation. siRNA knockdown, selective mPRα agonist (Org OD 02-0), pertussis toxin, pharmacological inhibitors (PD98059, ML-9, 8-Br-cAMP, forskolin, calpeptin), Ca2+ imaging Journal of molecular endocrinology High 31416049
2021 Progesterone acting through PAQR7 (mPRα) increases SERCA2 protein expression and phospholamban (PLB) phosphorylation in human VSMCs, leading to increased Ca2+ uptake into the SR and VSMC relaxation; these effects required Gi, MAP kinase, Akt/PI3K signaling and RhoA downregulation, and were abolished by SERCA2 siRNA or the SERCA inhibitor cyclopiazonic acid. siRNA knockdown (mPRα, SERCA2), pharmacological inhibitors, SERCA protein expression assay, PLB phosphorylation assay, Ca2+ measurement American journal of physiology. Endocrinology and metabolism High 33427050
2022 Homology modeling of PAQR7 (mPRα) based on AdipoR crystal structures revealed an intracellular N-terminus orientation and a zinc-binding pocket; mutational analysis showed Q206 forms a critical H-bond with the 20-carbonyl of progesterone (Q206R mutant lost progesterone binding), and V146 in TM3 is essential for hydrophobic binding (V146S mutant lost binding); high Zn2+ restored progesterone binding to Q206R mutant by displacing oleic acid from the binding pocket. Homology modeling, site-directed mutagenesis, [3H]-progesterone binding assay, Zn2+ supplementation The Journal of steroid biochemistry and molecular biology High 35189329
2023 PAQR7 (mPRα) mediates neuroprotective effects of progesterone in a Parkinson's disease cell model (SH-SY5Y cells treated with 6-OHDA and MPP+); the PI3K-AKT and MAP kinase signaling pathways are required for this neuroprotection, and mPRα-specific siRNA silencing abolished the effect while nuclear PR agonist R5020 and GABAA agonist muscimol were ineffective. siRNA knockdown, selective mPRα agonist (Org OD 02-0), pharmacological inhibitors, cell viability assay Frontiers in endocrinology Medium 36967764
2021 PAQR7 (mPRα) activation in Schwann cell-like differentiated adipose stem cells promotes cell migration, differentiation, and BDNF release; mPRα localization changed upon agonist treatment, and Src and PI3K-Akt signaling pathways were identified as downstream mediators. siRNA knockdown, selective mPRα agonist, migration assay, BDNF ELISA, immunofluorescence/localization, pharmacological inhibitors Molecular and cellular endocrinology Medium 33930460
2024 PAQR7 (Paqr7) knockout in female mice causes increased granulosa cell apoptosis, reduced follicular growth, increased follicular atresia, decreased E2 and AMH concentrations, reduced litter sizes, and impaired spontaneous ovulation; siRNA knockdown of PAQR7 in human KGN cells increased apoptosis that was rescued by progesterone supplementation, mediated through the BCL-2/BAX/CASPASE-3 signaling pathway. PAQR7 knockout mice, siRNA knockdown, apoptosis assays, hormone measurements, follicle counting Journal of ovarian research Medium 38317224
2022 A steroid binding assay for PAQR7 (mPRα) was established using graphene quantum dot (GQD)-conjugated mPRα; GQD-mPRα formed a complex with progesterone-BSA-FITC that was competitively displaced by free progesterone, confirming ligand-receptor binding activity at the protein level. GQD conjugation, fluorescence binding assay, competitive displacement with free progesterone Biochemical and biophysical research communications Medium 35007844
2025 2-hydroxypentanoic acid (2-HPA) from marine algae Padina acts as a novel PAQR7 (mPRα) antagonist; it showed competitive binding affinity for human mPRα in a GQD-mPRα binding assay and inhibited progesterone-induced oocyte maturation and ovulation in fish models, while structural analogues were inactive. GQD-mPRα competitive binding assay, goldfish oocyte maturation assay, zebrafish in vivo ovulation assay Biochemical and biophysical research communications Medium 39922053
2016 A PAQR7-related receptor (Paqr7b) in tongue sole regulates oocyte maturation; morpholino antisense knockdown of Paqr7b in oocytes blocked progestin-induced oocyte maturation, establishing a functional role for this mPRα-related receptor in mediating nongenomic progestin signaling at the membrane. Morpholino antisense oligonucleotide microinjection, oocyte maturation assay, in situ hybridization, tissue expression analysis General and comparative endocrinology Medium 27554928

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1996 Expression of a new G protein-coupled receptor X-msr is associated with an endothelial lineage in Xenopus laevis. Mechanisms of development 110 8951791
1999 Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ. Mechanisms of development 109 10473142
2020 Metabolic characterisation of Magnetospirillum gryphiswaldense MSR-1 using LC-MS-based metabolite profiling. RSC advances 104 35516490
2004 Characterization and prevalence of MefA, MefE, and the associated msr(D) gene in Streptococcus pneumoniae clinical isolates. Journal of clinical microbiology 90 15297499
2002 Expression of the murine msr/apj receptor and its ligand apelin is upregulated during formation of the retinal vessels. Mechanisms of development 81 11744380
2000 Dissociation of the high density lipoprotein and low density lipoprotein binding activities of murine scavenger receptor class B type I (mSR-BI) using retrovirus library-based activity dissection. The Journal of biological chemistry 79 10734045
2003 Msr(A) and related macrolide/streptogramin resistance determinants: incomplete transporters? International journal of antimicrobial agents 78 13678826
2007 Purified and sterilized magnetosomes from Magnetospirillum gryphiswaldense MSR-1 were not toxic to mouse fibroblasts in vitro. Letters in applied microbiology 69 17594464
2004 The PmlI-PmlR quorum-sensing system in Burkholderia pseudomallei plays a key role in virulence and modulates production of the MprA protease. Journal of bacteriology 68 15060030
2005 Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA. Journal of bacteriology 65 15601704
2008 Ferrous iron transport protein B gene (feoB1) plays an accessory role in magnetosome formation in Magnetospirillum gryphiswaldense strain MSR-1. Research in microbiology 63 18639631
2009 Arabidopsis thaliana plastidial methionine sulfoxide reductases B, MSRBs, account for most leaf peptide MSR activity and are essential for growth under environmental constraints through a role in the preservation of photosystem antennae. The Plant journal : for cell and molecular biology 60 19874542
2011 Semicontinuous culture of Magnetospirillum gryphiswaldense MSR-1 cells in an autofermentor by nutrient-balanced and isosmotic feeding strategies. Applied and environmental microbiology 58 21724877
2003 The msr/apj gene encoding the apelin receptor is an early and specific marker of the venous phenotype in the retinal vasculature. Gene expression patterns : GEP 58 12915314
2003 Characteristic expression of three genes, msr(A), mph(C) and erm(Y), that confer resistance to macrolide antibiotics on Staphylococcus aureus. FEMS microbiology letters 57 12670694
2008 High-yield growth and magnetosome formation by Magnetospirillum gryphiswaldense MSR-1 in an oxygen-controlled fermentor supplied solely with air. Applied microbiology and biotechnology 56 18425510
2011 Components of the Rv0081-Rv0088 locus, which encodes a predicted formate hydrogenlyase complex, are coregulated by Rv0081, MprA, and DosR in Mycobacterium tuberculosis. Journal of bacteriology 49 21821774
1997 The multiple roles of macrophage scavenger receptors (MSR) in vivo: resistance to atherosclerosis and susceptibility to infection in MSR knockout mice. Journal of atherosclerosis and thrombosis 42 9583348
2012 FeoB2 Functions in magnetosome formation and oxidative stress protection in Magnetospirillum gryphiswaldense strain MSR-1. Journal of bacteriology 40 22636767
1990 mprA, an Escherichia coli gene that reduces growth-phase-dependent synthesis of microcins B17 and C7 and blocks osmoinduction of proU when cloned on a high-copy-number plasmid. Journal of bacteriology 40 2152912
1991 Nucleotide sequence of the Escherichia coli regulatory gene mprA and construction and characterization of mprA-deficient mutants. Journal of bacteriology 39 1840583
2001 Uptake of fibrillar beta-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice. Neuroreport 38 11338182
2014 Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes. Frontiers in microbiology 37 25538698
2015 Transcriptional attenuation controls macrolide inducible efflux and resistance in Streptococcus pneumoniae and in other Gram-positive bacteria containing mef/mel(msr(D)) elements. PloS one 35 25695510
2006 Staphylococcus efflux msr(A) gene characterized in Streptococcus, Enterococcus, Corynebacterium, and Pseudomonas isolates. Antimicrobial agents and chemotherapy 35 16495276
2012 Functional interplay between the ATP binding cassette Msr(D) protein and the membrane facilitator superfamily Mef(E) transporter for macrolide resistance in Escherichia coli. Research in microbiology 33 23261969
2019 Optimized PCR conditions minimizing the formation of chimeric DNA molecules from MPRA plasmid libraries. BMC genomics 31 31291895
2021 Effects of Long-Term Exposure to Copper on the Keap1/Nrf2 Signaling Pathway and Msr-Related Redox Status in the Kidneys of Rats. Biological trace element research 30 33479888
2015 Predominant role of msr(D) over mef(A) in macrolide resistance in Streptococcus pyogenes. Microbiology (Reading, England) 30 26531240
2010 mamO and mamE genes are essential for magnetosome crystal biomineralization in Magnetospirillum gryphiswaldense MSR-1. Research in microbiology 29 20674739
2004 Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. Biochimie 28 15589683
2023 Role of Oxidative Stress, Methionine Oxidation and Methionine Sulfoxide Reductases (MSR) in Alzheimer's Disease. Antioxidants (Basel, Switzerland) 27 38275641
2013 Regulation of MSR-1 and CD36 in macrophages by LOX-1 mediated through PPAR-γ. Biochemical and biophysical research communications 27 23333385
2018 QuASAR-MPRA: accurate allele-specific analysis for massively parallel reporter assays. Bioinformatics (Oxford, England) 25 29028988
2019 Methionine sulfoxide reductase (Msr) dysfunction in human brain disease. Free radical research 23 31775527
2018 Progesterone induces relaxation of human umbilical cord vascular smooth muscle cells through mPRα (PAQR7). Molecular and cellular endocrinology 21 29428395
2018 Development of a simple intensified fermentation strategy for growth of Magnetospirillum gryphiswaldense MSR-1: Physiological responses to changing environmental conditions. New biotechnology 21 29864580
2006 Molecular epidemiology of macrolide resistance in beta-haemolytic streptococci of Lancefield groups A, B, C and G and evidence for a new mef element in group G streptococci that carries allelic variants of mef and msr(D). The Journal of antimicrobial chemotherapy 21 16431859
2022 Molecular modeling, mutational analysis and steroid specificity of the ligand binding pocket of mPRα (PAQR7): Shared ligand binding with AdipoR1 and its structural basis. The Journal of steroid biochemistry and molecular biology 19 35189329
2013 Expression patterns of key iron and oxygen metabolism genes during magnetosome formation in Magnetospirillum gryphiswaldense MSR-1. FEMS microbiology letters 19 23937222
2024 Characterization of enhancer activity in early human neurodevelopment using Massively Parallel Reporter Assay (MPRA) and forebrain organoids. Scientific reports 17 38365907
2021 Involvement of sarco/endoplasmic reticulum Ca2-ATPase (SERCA) in mPRα (PAQR7)-mediated progesterone induction of vascular smooth muscle relaxation. American journal of physiology. Endocrinology and metabolism 17 33427050
2019 Role of mPRα (PAQR7) in progesterone-induced Ca2+ decrease in human vascular smooth muscle cells. Journal of molecular endocrinology 17 31416049
2018 Functional Predominance of msr(D), Which Is More Effective as mef(A)-Associated Than mef(E)-Associated, Over mef(A)/mef(E) in Macrolide Resistance in Streptococcus pyogenes. Microbial drug resistance (Larchmont, N.Y.) 17 29406792
2016 Transcriptome analysis reveals physiological characteristics required for magnetosome formation in Magnetospirillum gryphiswaldense MSR-1. Environmental microbiology reports 17 27043321
2015 Iron response regulator protein IrrB in Magnetospirillum gryphiswaldense MSR-1 helps control the iron/oxygen balance, oxidative stress tolerance, and magnetosome formation. Applied and environmental microbiology 17 26386052
2017 Physiological characteristics of Magnetospirillum gryphiswaldense MSR-1 that control cell growth under high-iron and low-oxygen conditions. Scientific reports 16 28584275
2013 MamX encoded by the mamXY operon is involved in control of magnetosome maturation in Magnetospirillum gryphiswaldense MSR-1. BMC microbiology 16 24020498
2012 Two bifunctional enzymes with ferric reduction ability play complementary roles during magnetosome synthesis in Magnetospirillum gryphiswaldense MSR-1. Journal of bacteriology 16 23243303
2021 Fusion expression of nanobodies specific for the insecticide fipronil on magnetosomes in Magnetospirillum gryphiswaldense MSR-1. Journal of nanobiotechnology 15 33468141
2007 A novel ferric reductase purified from Magnetospirillum gryphiswaldense MSR-1. Current microbiology 15 17534559
1995 Developmental and pathogen-induced activation of an msr gene, str 246C, from tobacco involves multiple regulatory elements. Molecular & general genetics : MGG 15 7770037
2023 Progesterone exerts a neuroprotective action in a Parkinson's disease human cell model through membrane progesterone receptor α (mPRα/PAQR7). Frontiers in endocrinology 14 36967764
2022 MSR-RCNN: A Multi-Class Crop Pest Detection Network Based on a Multi-Scale Super-Resolution Feature Enhancement Module. Frontiers in plant science 14 35310676
2017 PGLP-1, a novel long-acting dual-function GLP-1 analog, ameliorates streptozotocin-induced hyperglycemia and inhibits body weight loss. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 14 28461341
2007 Development and clinical evaluation of a PCR assay targeting the metalloprotease gene (mprA) of B. pseudomallei. Zoonoses and public health 14 17359446
2022 Time-Sensitive Aspects of Mars Sample Return (MSR) Science. Astrobiology 13 34904889
2021 Membrane progesterone receptor α (mPRα/PAQR7) promotes migration, proliferation and BDNF release in human Schwann cell-like differentiated adipose stem cells. Molecular and cellular endocrinology 13 33930460
2020 The Novel Macrolide Resistance Genes mef(D), msr(F), and msr(H) Are Present on Resistance Islands in Macrococcus canis, Macrococcus caseolyticus, and Staphylococcus aureus. Antimicrobial agents and chemotherapy 13 32122903
2012 Crystallization and preliminary crystallographic analysis of the C-terminal domain of MamM, a magnetosome-associated protein from Magnetospirillum gryphiswaldense MSR-1. Acta crystallographica. Section F, Structural biology and crystallization communications 13 22869124
2007 Disruption of a fur-like gene inhibits magnetosome formation in Magnetospirillum gryphiswaldense MSR-1. Biochemistry. Biokhimiia 13 18205608
2021 PAQR7: An intermediary mediating nongenomic progesterone action in female reproductive tissue. Reproductive biology 12 34217103
2021 A comprehensive assessment of the biocompatibility of Magnetospirillum gryphiswaldense MSR-1 bacterial magnetosomes in vitro and in vivo. Toxicology 12 34534559
2022 Establishment of a steroid binding assay for membrane progesterone receptor alpha (PAQR7) by using graphene quantum dots (GQDs). Biochemical and biophysical research communications 11 35007844
2022 circRNA-MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR-761 in osteoarthritis. The Kaohsiung journal of medical sciences 11 36278814
2021 CircRNA-MSR Regulates LPS-Induced C28/I2 Chondrocyte Injury through miR-643/MAP2K6 Signaling Pathway. Cartilage 11 34581623
2022 Planning Implications Related to Sterilization-Sensitive Science Investigations Associated with Mars Sample Return (MSR). Astrobiology 10 34904892
2023 Genome-Wide Identification and Characterization of the Msr Gene Family in Alfalfa under Abiotic Stress. International journal of molecular sciences 9 37298589
2023 Biosynthesis of magnetosome-nanobody complex in Magnetospirillum gryphiswaldense MSR-1 and a magnetosome-nanobody-based enzyme-linked immunosorbent assay for the detection of tetrabromobisphenol A in water. Analytical and bioanalytical chemistry 9 37934249
2021 Predicted transmembrane proteins with homology to Mef(A) are not responsible for complementing mef(A) deletion in the mef(A)-msr(D) macrolide efflux system in Streptococcus pneumoniae. BMC research notes 9 34823574
2019 Effects of Environmental Conditions on High-Yield Magnetosome Production by Magnetospirillum gryphiswaldense MSR-1. Iranian biomedical journal 9 30797225
2016 Identification and characterization of a progestin and adipoQ receptor (PAQR) structurally related to Paqr7 in the ovary of Cynoglossus semilaevis and its potential role in regulating oocyte maturation. General and comparative endocrinology 9 27554928
2015 Correlation between genetic features of the mef(A)-msr(D) locus and erythromycin resistance in Streptococcus pyogenes. Diagnostic microbiology and infectious disease 9 26429294
2018 Design tools for MPRA experiments. Bioinformatics (Oxford, England) 8 30052913
2007 A CBS haplotype and a polymorphism at the MSR gene are associated with cardiovascular disease in a Spanish case-control study. Clinical biochemistry 8 17553479
2023 Pan msr gene deleted strain of Salmonella Typhimurium suffers oxidative stress, depicts macromolecular damage and attenuated virulence. Scientific reports 7 38071209
2022 Relevance of methionine sulfoxide reductase(s) (MSR) as candidate proteins in redox homeostasis-mediated resistance response to Helicoverpa armigera (Hübner) in the pigeonpea wild relative Cajanus platycarpus (Benth.) Maesen. International journal of biological macromolecules 7 35718158
2017 The Disruption of an OxyR-Like Protein Impairs Intracellular Magnetite Biomineralization in Magnetospirillum gryphiswaldense MSR-1. Frontiers in microbiology 7 28261169
2016 A novel role for Crp in controlling magnetosome biosynthesis in Magnetospirillum gryphiswaldense MSR-1. Scientific reports 7 26879571
2023 Streptococcus pyogenes Φ1207.3 Is a Temperate Bacteriophage Carrying the Macrolide Resistance Gene Pair mef(A)-msr(D) and Capable of Lysogenizing Different Streptococci. Microbiology spectrum 6 36625667
2015 ClpP-independent function of ClpX interferes with telithromycin resistance conferred by Msr(A) in Staphylococcus aureus. Antimicrobial agents and chemotherapy 6 25801573
2009 A thiol-activated lipase from Trichosporon asahii MSR 54: detergent compatibility and presoak formulation for oil removal from soiled cloth at ambient temperature. Journal of industrial microbiology & biotechnology 6 19165516
2008 [Using MSR model to analyze the impact of gene-gene interaction with related to the genetic polymorphism of metabolism enzymes on the risk of breast cancer]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 6 19024313
2023 Hexavalent chromate bioreduction by a magnetotactic bacterium Magnetospirillum gryphiswaldense MSR-1 and the effect of magnetosome synthesis. Chemosphere 5 37088211
2023 Evaluation of cell disruption technologies on magnetosome chain length and aggregation behaviour from Magnetospirillum gryphiswaldense MSR-1. Frontiers in bioengineering and biotechnology 5 37214292
2023 Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids. bioRxiv : the preprint server for biology 5 37645832
2022 Macrolides mediate transcriptional activation of the msr(E)-mph(E) operon through histone-like nucleoid-structuring protein (HNS) and cAMP receptor protein (CRP). The Journal of antimicrobial chemotherapy 5 34747464
2021 Continuous stimulation of dual-function peptide PGLP-1-VP inhibits the morbidity and mortality of NOD mice through anti-inflammation and immunoregulation. Scientific reports 5 33574570
2024 Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice. Journal of ovarian research 4 38317224
2022 Successful Intra- but Not Inter-species Recombination of msr(D) in Neisseria subflava. Frontiers in microbiology 4 35432273
2022 Methionine strengthens anti-inflammation of rice protein via depressing NF-κB activation and stimulating Msr expression in rats fed cholesterol-enriched diets. Food science and biotechnology 4 35646410
2021 The novel macrolide resistance genes mef(F) and msr(G) are located on a plasmid in Macrococcus canis and a transposon in Macrococcus caseolyticus. The Journal of antimicrobial chemotherapy 4 33118027
2019 Work Patterns of MamXY Proteins during Magnetosome Formation in Magnetospirillum gryphiswaldense MSR-1. Applied and environmental microbiology 4 30367002
2019 Novel Protein Mg2046 Regulates Magnetosome Synthesis in Magnetospirillum gryphiswaldense MSR-1 by Modulating a Proper Redox Status. Frontiers in microbiology 4 31297108
2025 Discovery of specific activity of 2-hydroxypentanoic acid acting on the mPR alpha (Paqr7) from the marine algae Padina. Biochemical and biophysical research communications 3 39922053
2024 Assessing the effects of NapA gene overexpression on denitrification and denitrogenation in magnetospirillum gryphiswaldense MSR-1. Archives of microbiology 3 39425777
2024 Bioinformatics of simultaneous, quantitative measurements of full-length tRNA and tRNA fragments by MSR sequencing. Methods in enzymology 3 39952712
2021 OxyR-Like Improves Cell Hydrogen Peroxide Tolerance by Participating in Monocyte Chemotaxis and Oxidative Phosphorylation Regulation in Magnetospirillum Gryphiswaldense MSR-1. Journal of biomedical nanotechnology 3 34974869
2018 Novel MprA binding motifs in the phoP regulatory region in Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland) 3 30205970
2010 Crystallization and preliminary crystallographic analysis of the Magnetospirillum magneticum AMB-1 and M. gryphiswaldense MSR-1 magnetosome-associated proteins MamA. Acta crystallographica. Section F, Structural biology and crystallization communications 3 20606283