Affinage

P2RX5

P2X purinoceptor 5 · UniProt Q93086

Length
444 aa
Mass
49.3 kDa
Annotated
2026-06-10
44 papers in source corpus 22 papers cited in narrative 22 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

P2RX5 (P2X5) is an ATP-gated cation channel of the P2X family that signals through purinergic ATP sensing to control differentiation and inflammatory output across muscle, immune, and adipose tissues (PMID:8786426, PMID:12135987, PMID:28298636). The receptor has the canonical two-transmembrane topology with a large extracellular ATP-binding loop, desensitizes slowly, and is insensitive to alpha,beta-methylene-ATP, distinguishing it from P2X1/P2X3 (PMID:8786426). Functional assembly requires a complete second transmembrane domain: trimerization depends on TM2 integrity and a conserved aspartate (Asp355), so that full-length human P2X5 (retaining exon 10) traffics to the cell surface and forms a channel permeable to Ca2+, Na+, NMDG, and Cl-, whereas the common exon-10-skipped human isoform lacks part of TM2, aggregates, remains cytoplasmic, and is non-functional (PMID:12761352, PMID:17001079, PMID:20223879). Gating is tuned by extracellular Ca2+, Zn2+, and pH and by left-flipper domain allostery, where human-type residues in this region permit fuller pore opening (PMID:12237343, PMID:31727741). Beyond homomers, P2X5 co-assembles into heteromeric channels with P2X1, P2X2, or P2X4, conferring hybrid pharmacology and kinetics, and P2X2/5 heteromers acquire pore-dilatation and phosphatidylserine-exposure properties; such P2X1/5 heteromers underlie native ATP currents in astrocytes (PMID:9855626, PMID:10336430, PMID:22442090, PMID:18495881). Physiologically, ATP activation of P2X5 drives p38 MAPK-dependent skeletal muscle satellite cell differentiation (PMID:12135987), licenses inflammasome activation and IL-1beta production required for osteoclast hyper-multinucleation and for macrophage cytosolic killing of Listeria monocytogenes (PMID:28298636, PMID:32540996), and in osteoclasts the C-terminal intracellular region binds the PRMT5 cofactor MEP50 to support maturation (PMID:31432503). P2X5 also regulates T cell IL-10 production and is required for brown adipocyte differentiation, BAT browning, and glucose disposal into brown adipose tissue (PMID:25181038, PMID:39484996, PMID:40650249). A genetic polymorphism creating the exon-10-skipped non-functional isoform underlies the minor histocompatibility antigen LRH-1, which is presented by HLA class I and elicits allogeneic CD8+ CTL responses (PMID:16322791).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 1996 High

    Established that P2X5 is a distinct ATP-gated ion channel, defining its existence as a slowly-desensitizing purinergic receptor with a unique pharmacology separating it from other P2X subunits.

    Evidence cDNA cloning, heterologous expression, and electrophysiology

    PMID:8786426

    Open questions at the time
    • Native cell type of action not established
    • No physiological function assigned
  2. 1999 High

    Resolved that P2X5 is not solely a homomeric channel but co-assembles with P2X1 into heteromers, explaining hybrid ATP-current kinetics and broadening the receptor's functional repertoire.

    Evidence Heterologous co-expression, patch-clamp/two-electrode voltage clamp, and reciprocal co-immunoprecipitation/co-purification of epitope-tagged subunits

    PMID:10336430 PMID:10496954 PMID:9855626

    Open questions at the time
    • Subunit stoichiometry within the heteromer not defined
    • In vivo relevance not yet shown at this stage
  3. 2002 Medium

    Defined how the homomeric channel is gated allosterically by the extracellular environment, showing Ca2+, Zn2+, and pH tune ATP responsiveness.

    Evidence Two-electrode voltage clamp in Xenopus oocytes with ion substitution and modulator experiments

    PMID:12237343

    Open questions at the time
    • Structural basis of modulator binding sites not mapped
    • Studied for rat receptor only
  4. 2002 Medium

    Assigned the first physiological role to P2X5 activation: linking ATP sensing to a p38 MAPK-driven switch from proliferation to differentiation in muscle satellite cells.

    Evidence Primary satellite cell cultures with immunocytochemistry, RT-PCR, electrophysiology, and p38 inhibitor rescue

    PMID:12135987

    Open questions at the time
    • Direct coupling between channel ion flux and p38 activation not established
    • Single lab, rat cells
  5. 2003 High

    Characterized the full-length human receptor as a genuinely functional, broadly permeable channel (Ca2+, Na+, NMDG, Cl-), establishing the human ortholog's biophysical baseline.

    Evidence Patch-clamp, fluorescence imaging, and reversal-potential measurements in HEK293 cells

    PMID:12761352

    Open questions at the time
    • Did not address why most humans express a non-functional isoform
  6. 2006 High

    Explained at the molecular level why the truncated human variant fails: trimerization requires a complete TM2, and the exon-10-skipped form is too short to insert and aggregates.

    Evidence Systematic mutagenesis, hydrophobic-stretch addition, and biochemical trimerization assays in heterologous cells

    PMID:17001079

    Open questions at the time
    • Role of Asp355 in the assembled trimer's gating not defined
  7. 2010 High

    Connected genotype to subcellular fate, showing the exon-10-deleted human isoform is cytoplasmic and non-functional while full-length P2X5 reaches the surface, and that most humans express only the non-functional form.

    Evidence Genotyping, RT-PCR, immunofluorescence, electrophysiology, and Ca2+ imaging in stable cell lines

    PMID:20223879

    Open questions at the time
    • Functional consequences in human tissues of carrying the non-functional allele not resolved
  8. 2005 Medium

    Showed the human expression polymorphism has direct immunological consequence, generating the LRH-1 minor histocompatibility antigen that drives allogeneic CD8+ CTL responses.

    Evidence Genetic linkage, tetramer CTL analysis, and protein expression studies in hematopoietic cells

    PMID:16322791

    Open questions at the time
    • Mechanism linking exon-10 skipping to antigen presentation not detailed
    • Single study
  9. 2012 High

    Expanded heteromer biology by demonstrating P2X2/5 channels with alternate stoichiometries that acquire pore-dilatation and phosphatidylserine-exposure properties previously attributed only to P2X7.

    Evidence BRET, bifunctional fluorescence complementation, protein biochemistry, and confocal colocalization in mouse brain

    PMID:22442090

    Open questions at the time
    • Functional output of P2X2/5 in specific neuronal circuits not defined
  10. 2017 High

    Established a genetic in vivo requirement for P2X5 in inflammatory signaling, linking it to inflammasome activation, IL-1beta production, and osteoclast hyper-multinucleation.

    Evidence P2rx5 knockout mice, osteoclast differentiation and inflammasome assays, and IL-1beta rescue

    PMID:28298636

    Open questions at the time
    • Molecular link from channel activity to inflammasome assembly not mapped
  11. 2019 Medium

    Identified an intracellular protein partner, showing the P2X5 C-terminus binds MEP50 to support osteoclast maturation beyond its channel role.

    Evidence Co-immunoprecipitation, RNAi, and domain-mapping rescue with C-terminal deletion mutant

    PMID:31432503

    Open questions at the time
    • Whether MEP50/PRMT5 activity is modulated by P2X5 binding not shown
    • Reciprocal validation limited
  12. 2019 High

    Explained the species difference in ATP sensitivity mechanistically, attributing weak rat P2X5 responses to left-flipper domain allostery that human-type residues relieve to permit full pore opening.

    Evidence Site-directed mutagenesis, patch-clamp, engineered disulfide cross-linking, single-channel recording, and molecular modeling

    PMID:31727741

    Open questions at the time
    • No high-resolution structure of the gating transition
  13. 2020 High

    Generalized the inflammatory role to host defense, showing P2X5 is required for macrophage cytosolic killing of Listeria via an inflammasome/IL-1beta/IL-18 pathway independent of ATP-P2X7.

    Evidence P2rx5 knockout mice, macrophage killing and inflammasome assays, cytokine rescue, and P2X7 comparison

    PMID:32540996

    Open questions at the time
    • Trigger that activates P2X5 during intracellular infection unclear
  14. 2014 Medium

    Implicated P2X5 in adaptive immune regulation, showing the human truncation variant is induced on activated T cells and restrains IL-10 production.

    Evidence Flow cytometry, siRNA knockdown, IL-10 ELISA, and surface expression analysis

    PMID:25181038

    Open questions at the time
    • How a non-functional channel isoform exerts this effect not explained
    • Single lab
  15. 2022 Medium

    Identified small-molecule modulators (dihydropyridines) and ligand-dependent ion-selectivity bias, revealing the channel's gating output is tunable by both pharmacology and agonist identity.

    Evidence Two-microelectrode voltage clamp in oocytes and BRET-based ion probes in live cells

    PMID:35335209 PMID:36343259

    Open questions at the time
    • Binding sites for dihydropyridines not localized
    • Physiological relevance of ligand bias unknown
  16. 2025 Medium

    Defined a metabolic role, showing P2X5 is required for brown adipocyte differentiation, BAT browning, and glucose disposal into brown fat, positioning it as an anti-obesity target.

    Evidence Global and brown-adipocyte-specific P2rx5 knockout mice, in vitro differentiation, calorimetry, glucose tolerance, and organ-specific uptake; in vivo agonist treatment

    PMID:39484996 PMID:40650249

    Open questions at the time
    • Whether the metabolic effect requires channel ion flux or a scaffolding function not resolved
    • Single lab
  17. 2025 Low

    Challenged the assumption of universal ATP-insensitivity by cataloguing ATP-sensitive splice isoforms across species, including a minority of functional human transcripts.

    Evidence Gene profiling, NGS, and RNA-seq from human tissues (preprint)

    PMID:bio_10.1101_2025.01.10.632374

    Open questions at the time
    • Awaits full functional reconstitution of all variants
    • Preprint, not peer-reviewed
    • Tissue-level protein expression not confirmed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a predominantly non-functional human isoform mediates immune and metabolic phenotypes, and whether the C-terminal MEP50 interaction and channel gating are mechanistically coupled, remains unresolved.
  • No structure of an assembled human P2X5 channel
  • Channel-independent (scaffolding) functions not separated from ion-flux functions
  • Endogenous activation trigger in disease contexts undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 4 GO:0005215 transporter activity 3 GO:0060089 molecular transducer activity 3
Localization
GO:0005886 plasma membrane 2 GO:0005829 cytosol 1
Pathway
R-HSA-1266738 Developmental Biology 2 R-HSA-162582 Signal Transduction 2 R-HSA-168256 Immune System 2
Partners
MEP50P2RX1P2RX2P2RX4
Complex memberships
P2X1/5 heteromeric receptorP2X2/5 heteromeric receptorP2X5 homotrimer

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 P2X5 is an ATP-gated ion channel with two transmembrane segments and a large extracellular loop; it desensitizes slowly and does not respond to alpha,beta-methylene-ATP, distinguishing it from P2X1/P2X3. cDNA cloning, heterologous expression, electrophysiology The Journal of neuroscience High 8786426
1998 P2X1 and P2X5 subunits co-assemble to form a novel heteromeric ATP-gated ion channel with distinct pharmacology (biphasic currents, non-desensitizing plateau) compared to homomeric P2X1; heteromeric assembly confirmed by co-immunoprecipitation of epitope-tagged subunits. Heterologous co-expression in HEK293 cells, patch-clamp electrophysiology, co-immunoprecipitation Molecular pharmacology High 9855626
1999 P2X1 and P2X5 subunits form hetero-oligomeric channels with the pharmacology of P2X1 (sensitivity to alpha,beta-methylene-ATP and TNP-ATP) but the slow desensitization kinetics of P2X5; physical co-assembly confirmed by reciprocal subunit-specific co-purification of epitope-tagged subunits in HEK-293A cells. Expression in Xenopus oocytes, two-electrode voltage clamp, reciprocal co-purification The Journal of biological chemistry High 10336430
1999 The heteromeric P2X1/5 receptor displays a distinct agonist rank order (ATP ≥ 2-methylthio-ATP > ATPγS > alpha,beta-meATP), is less sensitive to TNP-ATP than P2X1 alone, and plateau currents are potentiated by low PPADS concentrations and elevated extracellular Ca2+. Patch-clamp electrophysiology in HEK293 cells, concentration-response curves for agonists and antagonists Molecular pharmacology Medium 10496954
2002 Extracellular Ca2+ sensitizes the rat P2X5 homomeric receptor: replacement of Ca2+ with Ba2+ or Mg2+ produces very small agonist responses, while Ca2+-pulse conditioning restores robust responses; Zn2+ potentiates then inhibits ATP responses concentration-dependently, and lowering pH reduces ATP potency and efficacy. Two-electrode voltage clamp in Xenopus oocytes, ion substitution and modulator experiments Molecular pharmacology Medium 12237343
2002 Activation of P2X5 receptors on rat skeletal muscle satellite cells inhibits proliferation, stimulates expression of differentiation markers (myogenin, p21, myosin heavy chain), increases myotube formation, and rapidly increases p38 MAPK phosphorylation; inhibition of p38 prevents the effect of ATP on cell number. Primary satellite cell cultures, immunocytochemistry, RT-PCR, electrophysiology, p38 inhibitor experiments The Journal of cell biology Medium 12135987
2003 Full-length human P2X5 (including exon 10) forms a functional ATP-gated cation channel permeable to Ca2+ (PCa/PNa=1.5), Na+, NMDG (PNMDG/PNa=0.4), and Cl- (PCl/PNa=0.5) but not gluconate; it shows slow desensitization, is blocked by suramin, PPADS, and Brilliant Blue G, and rapidly accumulates YO-PRO-1 dye upon ATP application. Patch-clamp recording, fluorescence imaging, reversal potential measurements in HEK293 cells Molecular pharmacology High 12761352
2005 A frameshift polymorphism in P2X5 (exon 10 skipping) results in absence of protein expression in donor hematopoietic cells; differential P2X5 protein expression between donor and recipient generates the minor histocompatibility antigen LRH-1, which is presented by HLA class I and elicits an allogeneic CD8+ CTL response. Genetic linkage analysis, tetramer analysis of CTL responses, protein expression studies in hematopoietic cells The Journal of clinical investigation Medium 16322791
2006 P2X5 homotrimerization requires formation of a complete second transmembrane domain (TM2); the truncated human variant (lacking the C-terminal end of TM2 due to exon 10 skipping) is prone to subunit aggregation because the residual TM2 is too short to insert into the membrane. A single conserved aspartate residue (Asp355) in TM2 supports homotrimerization in a side-chain-specific manner. Systematic mutagenesis, hydrophobic stretch addition, biochemical analysis of trimerization in heterologous expression system The Journal of biological chemistry High 17001079
2008 P2X1 and P2X5 subunits together form the functional P2X receptor mediating ATP-induced currents in mouse cortical astrocytes; astrocyte ATP responses show high sensitivity (EC50 ~40 nM), biphasic kinetics, and PPADS sensitivity consistent with P2X1/5 heteromers. Quantitative PCR confirmed strong P2X1 and P2X5 mRNA expression in these cells. Whole-cell voltage clamp in acutely isolated astrocytes from transgenic mice, quantitative RT-PCR The Journal of neuroscience Medium 18495881
2010 The exon 10-deleted human P2X5 isoform (lacking 22 aa of TM2) is non-functional and localizes to the cytoplasm, whereas full-length P2X5 (containing exon 10) localizes to the cell surface and produces robust ATP-evoked currents and Ca2+ influx. Most humans carry the G-allele at the exon 10 splice site, resulting in exclusive expression of the non-functional isoform. Genotyping, RT-PCR, immunofluorescence of stably expressing cell lines, electrophysiology, fluorometric Ca2+ imaging Molecular pharmacology High 20223879
2012 P2X5 and P2X2 subunits interact to form heteromeric receptors with alternate stoichiometries at the plasma membrane; P2X2/5 receptors display pore dilatation, membrane blebbing, and phosphatidylserine exposure—functional hallmarks previously attributed exclusively to P2X7 receptors. P2X2 and P2X5 subunits colocalize and physically interact in specific mouse neuronal populations in vivo. Bioluminescence resonance energy transfer (BRET), bifunctional fluorescence complementation, protein biochemistry, confocal colocalization in mouse brain The Journal of neuroscience High 22442090
2014 Human P2RX5 (truncation variant lacking exon 10) is upregulated at mRNA and protein levels during T cell activation, is recruited to the cell surface, and siRNA-mediated knockdown of P2RX5 in CD4+ T cells leads to twofold increased IL-10 production, indicating a role in T cell immunoregulation. Flow cytometry, siRNA knockdown, ELISA for IL-10, surface expression analysis PloS one Medium 25181038
2017 P2X5 is required for ATP-mediated inflammasome activation and IL-1β production in osteoclasts; P2X5-deficient osteoclasts show defective hyper-multinucleation under inflammatory conditions, and this maturation defect is rescued in vitro by addition of exogenous IL-1β. P2rx5 knockout mice, osteoclast differentiation assays, inflammasome activation assays, IL-1β rescue experiment Scientific reports High 28298636
2019 Methylosome protein 50 (MEP50), a cofactor of PRMT5, physically associates with P2X5 via its C-terminal intracellular region; RNAi knockdown of MEP50 decreases mature osteoclast formation, and the defective osteoclast maturation in P2X5-deficient cells is rescued by full-length P2X5 but not by a C-terminal deletion mutant. Co-immunoprecipitation, RNAi knockdown, transduction with full-length vs. C-terminal deletion mutant P2X5, osteoclast differentiation assay FEBS letters Medium 31432503
2019 Weak ATP responses of rat P2X5 are due to altered allostery of the left flipper (LF) domain; single amino acid substitutions S191F or F195H (replacing rat residues with corresponding human P2X5 residues) significantly enhance current amplitude. Engineered disulfide cross-linking and molecular modeling show that these substitutions alter LF domain allostery to allow full pore opening. Site-directed mutagenesis, patch-clamp electrophysiology, engineered disulfide cross-linking, single-channel recording, molecular modeling The Journal of biological chemistry High 31727741
2020 P2X5 is required for cytosolic killing of Listeria monocytogenes by macrophages and for L. monocytogenes-induced inflammasome activation and IL-1β/IL-18 production; defective killing in P2X5-deficient macrophages is substantially rescued by exogenous IL-1β or IL-18. This P2X5-dependent pathway is independent of ATP-P2X7 inflammasome activation. P2rx5 knockout mice, bone marrow-derived macrophage killing assays, inflammasome activation assays, cytokine rescue experiments, P2X7 deficiency comparison Journal of immunology High 32540996
2022 Dihydropyridines isradipine and nimodipine potentiate ATP-induced currents through the full-length human P2X5 receptor at low micromolar concentrations, while amlodipine inhibits only at high (300 µM) concentrations. The full-length hP2X5 receptor shows Cl- permeability and gating kinetics consistent with prior reports. Two-microelectrode voltage clamp in Xenopus oocytes expressing hP2X5FL, pharmacological screening Molecules Medium 35335209
2022 Using BRET-based probes, concentration- and time-dependent ligand bias in cationic selectivity (differential Ca2+ vs. K+ permeability) was detected in P2X5 when activated by benzoyl-ATP (Bz-ATP), indicating dynamic ion selectivity changes dependent on ligand identity. BRET-based ion concentration probes in live cells during drug challenge Proceedings of the National Academy of Sciences of the United States of America Medium 36343259
2024 P2RX5 knockout in mice causes reduced brown adipocyte differentiation in vitro and reduced browning in vivo; P2RX5 agonism exerts an anti-obesity effect under thermoneutral conditions with enhanced BAT recruitment, indicating P2RX5 mediates brown adipocyte differentiation and function. P2rx5 knockout mice, in vitro brown adipocyte differentiation assays, metabolic characterization, in vivo agonist treatment Adipocyte Medium 39484996
2025 P2X5 modulates glucose metabolism in brown adipose tissue (BAT): both global and brown adipocyte-specific P2rx5 deficiency results in lower UCP1 expression and impaired glucose tolerance, with reduced glucose disposal specifically into BAT but not other organs. Global and tissue-specific knockout mice, indirect calorimetry, glucose tolerance tests, organ-specific glucose uptake measurements International journal of molecular sciences Medium 40650249
2025 ATP-sensitive P2X5 isoforms exist across species including humans: in mice ~90% of P2X5 transcripts encode the ATP-sensitive mP2X5 G317 form; in rats an exon 3-containing variant accounts for >70%; in human cell lines ATP-sensitive isoforms retaining exons 3, 7, and 10 represent ~15-30% of transcripts. These findings challenge the prevailing assumption that P2X5 is universally ATP-insensitive. Gene profiling, next-generation sequencing (NGS), RNA-seq from human tissues bioRxivpreprint Low bio_10.1101_2025.01.10.632374

Source papers

Stage 0 corpus · 44 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1996 Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. The Journal of neuroscience : the official journal of the Society for Neuroscience 768 8786426
2014 ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science translational medicine 163 25080478
2008 P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience 142 18495881
2005 A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia. The Journal of clinical investigation 117 16322791
1998 Co-expression of P2X1 and P2X5 receptor subunits reveals a novel ATP-gated ion channel. Molecular pharmacology 112 9855626
2003 Pharmacological and biophysical properties of the human P2X5 receptor. Molecular pharmacology 111 12761352
2002 ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells. The Journal of cell biology 105 12135987
1999 Localisation of P2X5 and P2X7 receptors by immunohistochemistry in rat stratified squamous epithelia. Cell and tissue research 94 10370147
1999 Functional and biochemical evidence for heteromeric ATP-gated channels composed of P2X1 and P2X5 subunits. The Journal of biological chemistry 75 10336430
2012 P2X2 and P2X5 subunits define a new heteromeric receptor with P2X7-like properties. The Journal of neuroscience : the official journal of the Society for Neuroscience 60 22442090
1999 Properties of the novel ATP-gated ionotropic receptor composed of the P2X(1) and P2X(5) isoforms. Molecular pharmacology 60 10496954
2000 Evidence for P2X(3), P2X(4), P2X(5) but not for P2X(7) containing purinergic receptors in Müller cells of the rat retina. Brain research. Molecular brain research 59 10762695
2017 The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts. Scientific reports 51 28298636
2002 Sensitization by extracellular Ca(2+) of rat P2X(5) receptor and its pharmacological properties compared with rat P2X(1). Molecular pharmacology 48 12237343
2006 P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate. The Journal of biological chemistry 47 17001079
1999 Expression of two ATP-gated ion channels, P2X5 and P2X6, in developing chick skeletal muscle. Developmental dynamics : an official publication of the American Association of Anatomists 47 10633863
2001 Loss of purinergic P2X(3) and P2X(5) receptor innervation in human detrusor from adults with urge incontinence. The Journal of neuroscience : the official journal of the Society for Neuroscience 45 11549755
2001 Genomic structure, developmental distribution and functional properties of the chicken P2X(5) receptor. Journal of neurochemistry 44 11389176
2004 The distribution of P2X5 purinergic receptors in the enteric nervous system of mouse. Cell and tissue research 42 15551155
2008 Expression of P2X5 receptors in the mouse CNS. Neuroscience 37 18773945
2008 Expression of P2X5 in lymphoid malignancies results in LRH-1-specific cytotoxic T-cell-mediated lysis. British journal of haematology 34 18410452
2010 Genetic and functional analysis of human P2X5 reveals a distinct pattern of exon 10 polymorphism with predominant expression of the nonfunctional receptor isoform. Molecular pharmacology 32 20223879
2014 A truncation variant of the cation channel P2RX5 is upregulated during T cell activation. PloS one 27 25181038
2006 P2X5 receptors are expressed on neurons containing arginine vasopressin and nitric oxide synthase in the rat hypothalamus. Brain research 27 16765918
2018 The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis. BMB reports 25 30103845
2014 Correlation between urothelial differentiation and sensory proteins P2X3, P2X5, TRPV1, and TRPV4 in normal urothelium and papillary carcinoma of human bladder. BioMed research international 21 24868547
2020 Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes. Journal of immunology (Baltimore, Md. : 1950) 17 32540996
2001 Gene structure, chromosomal localization, cDNA cloning and expression of the mouse ATP-gated ionotropic receptor P2X5 subunit. Gene 14 11404011
2012 Developmental expression of P2X5 receptors in the mouse prenatal central and peripheral nervous systems. Purinergic signalling 13 23271560
2022 Rehabilitation of the P2X5 receptor: a re-evaluation of structure and function. Purinergic signalling 12 36279087
2009 Efficient activation of LRH-1-specific CD8+ T-cell responses from transplanted leukemia patients by stimulation with P2X5 mRNA-electroporated dendritic cells. Journal of immunotherapy (Hagerstown, Md. : 1997) 12 19483655
2019 Methylosome protein 50 associates with the purinergic receptor P2X5 and is involved in osteoclast maturation. FEBS letters 10 31432503
2019 Altered allostery of the left flipper domain underlies the weak ATP response of rat P2X5 receptors. The Journal of biological chemistry 8 31727741
2012 Expression of P2X5 receptors in the rat, cat, mouse and guinea pig dorsal root ganglion. Histochemistry and cell biology 8 23160624
2001 P2X(2), P2X(2-2) and P2X(5) receptor subunit expression and function in rat thoracolumbar sympathetic neurons. Journal of neurochemistry 8 11739611
2015 P2X2 and P2X5 Receptors Mediate Bladder Hyperesthesia in ICC in Female Overactive Bladder. Cell biochemistry and biophysics 7 25561285
2006 P2X(5) and P2X(7) receptors in human warts and CIN-612 organotypic raft cultures of human papillomavirus infected keratinocytes. Purinergic signalling 7 18404488
2024 A key role for P2RX5 in brown adipocyte differentiation and energy homeostasis. Adipocyte 6 39484996
2022 Dihydropyridines Potentiate ATP-Induced Currents Mediated by the Full-Length Human P2X5 Receptor. Molecules (Basel, Switzerland) 6 35335209
2022 Genetically-encoded BRET probes shed light on ligand bias-induced variable ion selectivity in TRPV1 and P2X5/7. Proceedings of the National Academy of Sciences of the United States of America 6 36343259
2023 Effect of Yiyuan moxibustion on urodynamics and TRPV4/ATP/P2X5 signal pathway of bladder tissue in rats with neurogenic bladder after sacral cord injury. Zhen ci yan jiu = Acupuncture research 3 37879945
2025 The Purinergic Receptor P2X5 Modulates Glucose Metabolism and Expression of Thermogenic Genes in Brown Adipose Tissue. International journal of molecular sciences 1 40650249
2026 The ancestral haplotype of P2RX5 yields a B-cell surface marker and a multi-lineage immunotherapy target. bioRxiv : the preprint server for biology 0 41648131
2015 [The Relationship Study between Expressions of P2X5 Receptor and Deficiency-cold Syndrome/Deficiency-heat Syndrome at Various Ambient Temperatures]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 0 26159019

Missed literature

Know a paper Affinage missed for P2RX5? Flag it for the maintainers and the community.

No submissions yet.