Affinage

OLIG1

Oligodendrocyte transcription factor 1 · UniProt Q8TAK6

Length
271 aa
Mass
27.9 kDa
Annotated
2026-06-10
44 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

OLIG1 is a basic helix-loop-helix transcription factor that operates at the crossroads of neuronal versus glial fate decisions and drives the oligodendrocyte differentiation and myelination program in the CNS (PMID:11955447, PMID:15703389). In progenitor specification, OLIG1 (with OLIG2) directs cells toward the oligodendrocyte lineage and away from interneuron fates: it directly binds and represses the Dlx1/2 I12b intergenic enhancer to restrain cortical GABAergic interneuron production (PMID:24507192), represses the Gsx2 enhancers to bias Tri-IPC progenitors toward OPC rather than OBIN-IPC fate (PMID:41193423), and is required downstream of BMP antagonism (Noggin) for OPC production after injury (PMID:28253550). During myelinogenesis it activates myelin-specific genes (Mbp, Plp1, Mag) and suppresses the astrocyte gene Gfap, with brain-specific requirement because spinal cord deficits are buffered by compensatory OLIG2 upregulation (PMID:15703389, PMID:25762682); mechanistically, OLIG1 partners with SOX10 to transactivate the mbp promoter (PMID:18160645). OLIG1 activity is governed by regulated nuclear-cytoplasmic shuttling: phosphorylation at Ser138 and acetylation at Lys150 (written by CBP and erased by HDAC1/3/10) drive nuclear export, where cytoplasmic OLIG1 promotes oligodendroglial membrane expansion while nuclear OLIG1 sustains myelin gene transcription (PMID:22639060, PMID:26631469). Cytoplasmic sequestration is enforced by direct binding partners including ID2, ID4, and TIP30, which block OLIG1 nuclear translocation (PMID:26631469, PMID:21132377, PMID:25530119). Beyond oligodendrocytes, OLIG1 acts as a Smad2/3 cofactor regulated by Pin1 to promote TGF-β-induced cell motility (PMID:23720758) and, with OLIG2, represses a Bmp7 enhancer to control astrocyte maturation (PMID:40139307).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2002 High

    Established the foundational role of Olig genes in coupling neuronal and glial subtype specification, answering whether a single factor class governs both motoneuron and oligodendrocyte production.

    Evidence Olig1/2 double-knockout mice with lineage tracing in the spinal cord pMN domain

    PMID:11955447

    Open questions at the time
    • Did not separate OLIG1- from OLIG2-specific contributions
    • Direct transcriptional targets not identified
  2. 2005 High

    Defined OLIG1 as a dedicated driver of brain myelinogenesis, distinguishing OPC formation from the subsequent differentiation/myelin-wrapping step it controls.

    Evidence Olig1-null mice with myelin gene expression analysis and electron microscopy

    PMID:15703389

    Open questions at the time
    • Direct DNA targets in myelin gene loci not mapped
    • Basis of brain vs spinal cord specificity unexplained at this stage
  3. 2007 High

    Identified a direct molecular mechanism for myelin gene activation by showing OLIG1 forms a transactivating complex with SOX10 on the mbp promoter.

    Evidence Co-IP and promoter-reporter assays in zebrafish and mouse

    PMID:18160645

    Open questions at the time
    • Cross-species divergence in OLIG2-SOX10 binding leaves complex stoichiometry unresolved
    • Full set of co-regulated promoters not defined
  4. 2007 Medium

    Placed Olig1/2 downstream of BMP signaling in the OPC-versus-astrocyte fate decision, clarifying how extracellular cues gate the oligodendrocyte program.

    Evidence Adult OPC culture with BMP treatment and olig1/olig2 overexpression rescue

    PMID:17872503

    Open questions at the time
    • Requires both Olig1 and Olig2 for full rescue, so Olig1-specific sufficiency unclear
    • Single lab
  5. 2010 High

    Connected Olig1/2 gene dosage to interneuron number, demonstrating that triplication causes excitatory/inhibitory imbalance reversible by dosage normalization.

    Evidence Genetic dosage normalization in Ts65Dn Down syndrome mice with cell counting and electrophysiology

    PMID:20639873

    Open questions at the time
    • Did not resolve direct transcriptional mechanism of interneuron suppression
    • Olig1 vs Olig2 individual dosage contribution not separated
  6. 2010 Low

    Provided first evidence that OLIG1 subcellular localization is regulated and correlates with remyelination, and that ID4 directly blocks its nuclear transport.

    Evidence Olig1 immunolocalization in EAE rat brain with progesterone treatment; BiFC of Olig1-ID4 dimer in cells

    PMID:20381586 PMID:21132377

    Open questions at the time
    • EAE/progesterone data are correlative without direct Olig1 manipulation
    • BiFC is single-method without functional differentiation readout
  7. 2012 High

    Identified Ser138 phosphorylation as a switch controlling OLIG1 nuclear-cytoplasmic distribution and uncoupling myelin gene transcription from membrane expansion.

    Evidence Phosphosite identification and S138A/S138D mutagenesis with rescue in Olig1-null OPCs and morphology quantification

    PMID:22639060

    Open questions at the time
    • Kinase responsible for Ser138 phosphorylation not identified
    • Cytoplasmic effector mechanism for membrane expansion undefined
  8. 2013 High

    Revealed a non-glial role for OLIG1 as a Smad2/3 cofactor in TGF-β-driven cell motility, regulated by Pin1.

    Evidence Reciprocal Co-IP mapping interaction to the Smad3 L3 loop, siRNA knockdown, migration/wound-healing assays, peptide inhibition

    PMID:23720758

    Open questions at the time
    • Target genes mediating motility not identified
    • Relevance to oligodendrocyte biology not established
  9. 2014 High

    Demonstrated that OLIG1 directly represses the Dlx1/2 enhancer to limit GABAergic interneuron production, providing the molecular basis for the neuron/glia fate switch.

    Evidence Olig1 conditional knockout, ChIP at the Dlx1/2 I12b enhancer, genetic epistasis, cell counting

    PMID:24507192

    Open questions at the time
    • Co-repressor complex at the enhancer not characterized
    • Interplay with OLIG2 at this locus not resolved
  10. 2014 Medium

    Identified TIP30 as a direct cytoplasmic sequestration factor controlling the timing of OLIG1 nuclear entry and OPC differentiation.

    Evidence Co-IP, TIP30 gain/loss-of-function in primary OPCs, localization imaging, cuprizone demyelination model

    PMID:25530119

    Open questions at the time
    • Reciprocal Co-IP not reported
    • Relationship between TIP30 and the phospho/acetyl shuttling code unknown
  11. 2015 High

    Defined an acetylation-based export code (Lys150, CBP writer, HDAC1/3/10 erasers, NES signals) that reduces chromatin association and routes OLIG1 to the cytoplasm via ID2 binding in mature oligodendrocytes.

    Evidence Lys150 mutagenesis, CBP/HDAC manipulation, chromatin association assays, Olig1-ID2 Co-IP, fractionation in mouse/rat oligodendrocytes

    PMID:26631469

    Open questions at the time
    • Crosstalk between Ser138 phosphorylation and Lys150 acetylation not resolved
    • In vivo significance of NES mutants not tested
  12. 2015 High

    Explained the brain-specific requirement for OLIG1 by showing compensatory OLIG2 protein upregulation rescues spinal but not brain myelination deficits.

    Evidence Olig1-null mouse analysis with OLIG2 quantification, electron microscopy, immunostaining in corpus callosum

    PMID:25762682

    Open questions at the time
    • Mechanism restricting OLIG2 compensation to spinal cord unknown
    • Long-term functional myelin consequences not fully characterized
  13. 2017 Medium

    Integrated OLIG1 into the BMP-antagonism injury response, positioning it downstream of Noggin to govern OL-versus-interneuron fate via Dlx1/2 repression after stroke.

    Evidence Olig1-null neonatal stroke model and Noggin-treated postnatal progenitor cultures with lineage marker staining

    PMID:28253550

    Open questions at the time
    • Direct link between Noggin signaling and Olig1 regulation not mapped molecularly
    • Single lab
  14. 2017 Medium

    Showed that Olig1/2 expression itself is set by chromatin state, with HMGN proteins preventing EZH2/H3K27me3-mediated silencing of the loci.

    Evidence HMGN-knockout ESC differentiation, ChIP for H1/EZH2/H3K27me3 at Olig1/2 loci, mouse phenotyping

    PMID:27923998

    Open questions at the time
    • Olig1- vs Olig2-locus-specific effects not separated
    • Upstream signals controlling HMGN occupancy unknown
  15. 2021 Low

    Linked pharmacological induction of cytoplasmic OLIG1 to oligodendroglial membrane maturation and GPR17 regulation, supporting the cytoplasmic non-transcriptional function.

    Evidence Quetiapine treatment of primary oligodendrocytes with localization imaging and GPR17 analysis

    PMID:33660902

    Open questions at the time
    • No direct genetic proof that Olig1 mediates quetiapine effect
    • Mechanism of GPR17 regulation by Olig1 not defined
  16. 2024 Medium

    Extended OLIG1 function to neuronal axon biology, showing it promotes spinal motor neuron axonal regeneration partly via transcriptional control of Nrsn1.

    Evidence Transcriptomics of motor neurons, Olig1 overexpression/deletion in regeneration models, Nrsn1 functional validation

    PMID:39002126

    Open questions at the time
    • Direct Olig1 binding at Nrsn1 not demonstrated
    • Full regenerative target set unknown
  17. 2025 High

    Mapped genome-wide enhancer/promoter binding establishing OLIG1/2 as direct repressors (Bmp7, Gsx2) in astrocyte maturation and gliogenic fate and direct activators (cyclins) driving GBM proliferation.

    Evidence Olig1/2 double-knockout mice, CUT&Tag-seq, scRNA-seq, H3K4me3 ChIP, in vivo overexpression phenocopy and CRISPR knockout in GBM

    PMID:40139307 PMID:40428395 PMID:41193423

    Open questions at the time
    • OLIG1-specific versus OLIG2-specific binding contributions not separated
    • Switch between repressive and activating modes at different loci not mechanistically explained

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the phosphorylation (Ser138) and acetylation (Lys150) shuttling codes are integrated with the sequestration partners (ID2/ID4/TIP30) and upstream signals to time the nuclear-to-cytoplasmic transition during differentiation remains unresolved.
  • No unified model linking PTM code to partner binding
  • Upstream kinase/signaling inputs not identified
  • In vivo significance of cytoplasmic OLIG1 function not genetically dissected

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 6 GO:0003677 DNA binding 4 GO:0060089 molecular transducer activity 1
Localization
GO:0005634 nucleus 4 GO:0005829 cytosol 4
Pathway
R-HSA-1266738 Developmental Biology 5 R-HSA-74160 Gene expression (Transcription) 5 R-HSA-162582 Signal Transduction 3
Partners
ID2ID4OLIG2PIN1SMAD2SMAD3SOX10TIP30

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 OLIG1 and OLIG2 are required for both motoneuron and oligodendrocyte specification in the spinal cord pMN domain; Olig1/2 double-mutant mice lose motoneurons and fail to generate oligodendrocytes, with pMN progenitors instead generating V2 interneurons and astrocytes, establishing that Olig genes couple neuronal and glial subtype specification. Genetic loss-of-function (Olig1/2 double-knockout mice), lineage tracing Cell High 11955447
2005 Olig1 is required for oligodendrocyte myelinogenesis specifically in the brain (not spinal cord); Olig1-null mice show abolished expression of myelin-specific genes (Mbp, Plp1, Mag), failure of multilamellar myelin wrapping around axons despite axonal contact, and Olig1 suppresses astrocyte-specific Gfap expression. Oligodendrocyte progenitor formation is unaffected. Olig1-null mouse genetic knockout, gene expression analysis, electron microscopy The Journal of neuroscience High 15703389
2007 OLIG1 physically associates with the transcription factor SOX10, and the OLIG1/SOX10 complex activates myelin basic protein (mbp) transcription through conserved DNA sequence motifs in the mbp promoter. In contrast, OLIG2 does not bind SOX10 in zebrafish, though both OLIG1 and OLIG2 bind SOX10 in mouse. Co-immunoprecipitation (physical interaction), promoter-reporter assays (transcriptional activation), zebrafish and mouse models The Journal of neuroscience High 18160645
2007 BMP2 and BMP4 inhibit oligodendrocyte differentiation of adult OPCs by downregulating olig1 and olig2 expression; overexpression of olig1 alone blocked BMP-induced astrocyte differentiation, but overexpression of both olig1 and olig2 together was required to rescue oligodendrocyte differentiation from BMP inhibition. Adult OPC culture, BMP treatment, overexpression of olig1/olig2 via transfection, immunostaining Stem cells Medium 17872503
2010 Olig1 and Olig2 triplication in the Ts65Dn Down syndrome mouse model causes overproduction of GABAergic interneurons and imbalance of excitatory/inhibitory tone; normalization of Olig1/Olig2 gene dosage (from 3 copies to 2) rescues the inhibitory neuron phenotype. Genetic dosage normalization in Ts65Dn mice, cell counting, electrophysiology Nature neuroscience High 20639873
2012 Olig1 is phosphorylated at serine 138 in the helix-loop-helix domain; this phosphorylated form resides in the cytosol. A serine-to-alanine mutation (S138A) restricts Olig1 to the nucleus and permits MBP expression but limits membrane expansion, while a serine-to-aspartate (phosphomimetic S138D) mutation causes cytoplasmic localization and enhances membrane expansion and oligodendrocyte maturation. Site-directed mutagenesis, nuclear-specific Olig1 expression in Olig1-null OPCs, phosphorylation site identification, cell morphology quantification Glia High 22639060
2013 OLIG1 functions as a Smad cofactor in TGF-β signaling: OLIG1 physically interacts with Smad2/3 (via the L3 loop of Smad3), and this interaction is regulated by the prolyl isomerase Pin1. Knockdown of OLIG1 attenuates TGF-β-induced cell motility (migration and wound healing) but has no effect on BMP-induced motility, TGF-β-induced cytostasis, or epithelial-mesenchymal transition. Co-immunoprecipitation (Smad2/3–Olig1 interaction), siRNA knockdown, chamber migration and wound healing assays, Pin1 knockdown, synthetic peptide inhibition The Journal of biological chemistry High 23720758
2014 Olig1 directly represses the Dlx1/2 I12b intergenic enhancer, and Dlx1/2 function genetically downstream of Olig1. Olig1 deletion in mice causes ectopic Dlx1/2 upregulation in the ventral medial ganglionic eminences and a ~30% increase in adult cortical GABAergic interneuron numbers. Olig1 conditional knockout mice, chromatin immunoprecipitation (Olig1 binding to Dlx1/2 I12b enhancer), genetic epistasis (Dlx1/2 downstream of Olig1), cell counting Neuron High 24507192
2014 TIP30 sequesters Olig1 in the cytoplasm by direct protein–protein interaction, preventing its nuclear translocation and thereby inhibiting OPC differentiation; TIP30 overexpression inhibits OPC stage progression while TIP30 knockdown enhances oligodendroglial differentiation and increases nuclear Olig1. Co-immunoprecipitation (TIP30–Olig1 interaction), TIP30 overexpression/knockdown in primary OPC cultures, subcellular localization by immunostaining, cuprizone demyelination model Glia Medium 25530119
2015 Olig1 acetylation at Lys150 (human Olig1) drives nuclear-to-cytoplasmic translocation. The acetyltransferase CBP (CREB-binding protein) and deacetylases HDAC1, HDAC3, and HDAC10 regulate this modification. Acetylation decreases Olig1 chromatin association, increases interaction with ID2, and facilitates cytoplasmic retention in mature oligodendrocytes. Three functional nuclear export sequences (NES) were identified in the bHLH domain. Identification of acetylation site (Lys150) by mutagenesis, CBP/HDAC overexpression/knockdown, chromatin association assays, Co-IP (Olig1–ID2 interaction), subcellular fractionation/immunostaining in mouse and rat oligodendrocytes The Journal of neuroscience High 26631469
2015 Olig1 is required for oligodendrocyte progenitor cell commitment and differentiation in the brain corpus callosum, with hypomyelination persisting into adulthood. In the spinal cord, compensatory upregulation of Olig2 protein (not seen in brain) partially rescues the deficit, explaining the regional difference in Olig1 requirement. Olig1-null mouse analysis, Olig2 protein quantification by Western blot and immunostaining, myelination assessment by electron microscopy and immunostaining The Journal of neuroscience High 25762682
2010 Olig1 protein translocates from the cytoplasm to the nucleus in EAE (demyelination) rat brains, and progesterone treatment increases the proportion of cells showing nuclear Olig1 localization, correlating with enhanced remyelination. Immunostaining for Olig1 subcellular localization in EAE rat brain, electron microscopy for myelin assessment, progesterone injection paradigm Neuroscience letters Low 20381586
2010 Olig1 and ID4 directly interact and form a dimer in living cells; the Olig1–ID4 complex localizes to the cytoplasm (whereas Olig1 alone is nuclear and ID4 alone is cytoplasmic), indicating that ID4 blocks nuclear transport of Olig1. Bimolecular fluorescence complementation (BiFC) in SW1116 cells, EGFP/DsRed2 fusion protein co-expression and colocalization Molecular biology reports Medium 21132377
2017 Olig1 function is required downstream of Noggin (BMP antagonism) for OPC production after neonatal stroke; in postnatal neural progenitors, Noggin governs OL versus interneuron fate through Olig1-mediated repression of Dlx1/2 transcription factors. Olig1-null neonatal mice show hypomyelination and replacement of OPCs with proliferating neuronal precursors and GABAergic interneurons in damaged white matter. Olig1-null mice subjected to neonatal stroke, postnatal neural progenitor cultures with Noggin treatment, immunostaining for lineage markers Annals of neurology Medium 28253550
2017 HMGN proteins regulate OLIG1 and OLIG2 expression through chromatin dynamics: loss of HMGNs increases histone H1 chromatin binding at Olig1/2 loci, recruiting the methyltransferase EZH2 and elevating H3K27me3 (repressive mark), thereby reducing Olig1/2 expression and impeding oligodendrocyte lineage specification. HMGN knockout ESC differentiation assays, ChIP for H1/EZH2/H3K27me3 at Olig1/2 loci, gene expression analysis, mouse behavioral and histological phenotyping Nucleic acids research Medium 27923998
2021 Quetiapine upregulates Olig1 expression and promotes nuclear-to-cytoplasmic translocation of Olig1, where cytoplasmic Olig1 (not as transcription factor) drives oligodendroglial membrane expansion and maturation. Quetiapine also reverses GPR17-mediated inhibition of oligodendroglial morphological maturation, with Olig1 identified as upstream regulator of GPR17. Primary oligodendrocyte cultures, quetiapine treatment, Olig1 subcellular localization by immunostaining, morphological quantification, GPR17 expression analysis Glia Low 33660902
2024 Olig1 promotes axonal regeneration in spinal motor neurons; Olig1 overexpression facilitates axonal regeneration in multiple injury models while deletion has the opposite effect. Olig1 acts at least partially through transcriptional regulation of the neurite extension factor Nrsn1. Transcriptomic profiling of motor neurons with differential regenerative capacity, Olig1 overexpression/deletion in regeneration models, identification of Nrsn1 as downstream target by differential gene expression and functional validation Cell reports Medium 39002126
2025 Olig1 and Olig2 coordinately regulate cortical astrocyte maturation by directly binding the Bmp7 enhancer and repressing Bmp7 expression; genetic ablation of both Olig1 and Olig2 results in defective astrocyte morphology and immature gene expression, while Bmp7 overexpression in vivo replicates this phenotype. Olig1/2 double knockout mice, single-cell RNA sequencing, ChIP/CUT&Tag for Olig1/2 binding at Bmp7 enhancer, Bmp7 overexpression in vivo Journal of genetics and genomics High 40139307
2025 Olig1 and Olig2 coordinately regulate Tri-IPC fate specification in cortical gliogenesis by activating OPC specification while repressing OBIN-IPC generation through direct binding to multiple conserved enhancer elements of Gsx2, suppressing its expression; Olig1/2 genetic ablation redirects progenitors from OPC to OBIN-IPC fate with Gsx2 upregulation. Olig1/2 double knockout mouse genetics, CUT&Tag-seq for Olig1/2 binding at Gsx2 enhancers, single-cell transcriptomics, in vivo mutagenesis Nature communications High 41193423
2025 OLIG1 and OLIG2 drive GBM tumor cell proliferation by directly binding to promoter regions of cyclins (Cdk4, Ccne2, Ccnd3, Ccnd1), marked by H3K4me3 (active histone mark), leading to transcriptional activation; Olig1/2 knockout reduces proliferation but does not suppress tumor initiation or migration. CRISPR/Cas9 Olig1/2 knockout in GBM mouse model, CUT&Tag-seq for Olig1/2 binding at cyclin promoters, H3K4me3 ChIP, tumor proliferation assays Genes Medium 40428395

Source papers

Stage 0 corpus · 44 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 847 11955447
2005 Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice. The Journal of neuroscience : the official journal of the Society for Neuroscience 214 15703389
2010 Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. Nature neuroscience 180 20639873
2007 Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience 143 18160645
2007 Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells. Stem cells (Dayton, Ohio) 112 17872503
2015 Olig1 function is required for oligodendrocyte differentiation in the mouse brain. The Journal of neuroscience : the official journal of the Society for Neuroscience 94 25762682
2003 Expression of the oligodendroglial lineage-associated markers Olig1 and Olig2 in different types of human gliomas. Journal of neuropathology and experimental neurology 72 14575240
2014 Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain. Neuron 58 24507192
2015 Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development. The Journal of neuroscience : the official journal of the Society for Neuroscience 50 26631469
2010 Progesterone attenuates neurological behavioral deficits of experimental autoimmune encephalomyelitis through remyelination with nucleus-sublocalized Olig1 protein. Neuroscience letters 50 20381586
2012 Phosphorylated olig1 localizes to the cytosol of oligodendrocytes and promotes membrane expansion and maturation. Glia 49 22639060
2011 Olig1 is expressed in human oligodendrocytes during maturation and regeneration. Glia 38 21446039
2009 olig1 Expression identifies developing oligodendrocytes in zebrafish and requires hedgehog and notch signaling. Developmental dynamics : an official publication of the American Association of Anatomists 38 19253391
2017 Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation. Nucleic acids research 36 27923998
2013 Increased nuclear Olig1-expression in the pregenual anterior cingulate white matter of patients with major depression: a regenerative attempt to compensate oligodendrocyte loss? Journal of psychiatric research 31 23615187
2014 New Olig1 null mice confirm a non-essential role for Olig1 in oligodendrocyte development. BMC neuroscience 28 24423059
2004 Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors. Journal of neuropathology and experimental neurology 28 14989603
2010 A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the Olig1 and Olig2 locus. PloS one 27 21206754
2004 Transient expression of Olig1 initiates the differentiation of neural stem cells into oligodendrocyte progenitor cells. Stem cells (Dayton, Ohio) 27 15536179
2012 Olig1 function is required for remyelination potential of transplanted neural progenitor cells in a model of viral-induced demyelination. Experimental neurology 25 22449475
2014 Effect of OLIG1 on the development of oligodendrocytes and myelination in a neonatal rat PVL model induced by hypoxia-ischemia. Molecular medicine reports 24 25435330
2011 Differential and cooperative actions of Olig1 and Olig2 transcription factors on immature proliferating cells after contusive spinal cord injury. Glia 24 21538562
2013 Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β. The Journal of biological chemistry 23 23720758
2004 Analysis of the bHLH transcription factors Olig1 and Olig2 in brain tumors. Journal of neuro-oncology 23 15164981
2017 Effect of catalpol on remyelination through experimental autoimmune encephalomyelitis acting to promote Olig1 and Olig2 expressions in mice. BMC complementary and alternative medicine 15 28464811
2023 Olig1/2-Expressing Intermediate Lineage Progenitors Are Predisposed to PTEN/p53-Loss-Induced Gliomagenesis and Harbor Specific Therapeutic Vulnerabilities. Cancer research 14 36634201
2017 Olig1 is required for noggin-induced neonatal myelin repair. Annals of neurology 14 28253550
2014 TIP30 inhibits oligodendrocyte precursor cell differentiation via cytoplasmic sequestration of Olig1. Glia 14 25530119
2021 Identification of CRYAB+ KCNN3+ SOX9+ Astrocyte-Like and EGFR+ PDGFRA+ OLIG1+ Oligodendrocyte-Like Tumoral Cells in Diffuse IDH1-Mutant Gliomas and Implication of NOTCH1 Signalling in Their Genesis. Cancers 13 33925547
2019 Effects of the transcription factor Olig1 on the differentiation and remyelination of oligodendrocyte precursor cells after focal cerebral ischemia in rats. Molecular medicine reports 13 31702031
2010 Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice. PloS one 12 20927333
2021 Quetiapine promotes oligodendroglial process outgrowth and membrane expansion by orchestrating the effects of Olig1. Glia 10 33660902
2021 The Shh/Gli1 signaling pathway regulates regeneration via transcription factor Olig1 expression after focal cerebral ischemia in rats. Neurological research 9 34592910
2010 Olig1 and ID4 interactions in living cells visualized by bimolecular fluorescence complementation technique. Molecular biology reports 7 21132377
2025 Coordinated regulation of cortical astrocyte maturation by OLIG1 and OLIG2 through BMP7 signaling modulation. Journal of genetics and genomics = Yi chuan xue bao 6 40139307
2021 Extreme Glycemic Fluctuations Debilitate NRG1, ErbB Receptors and Olig1 Function: Association with Regeneration, Cognition and Mood Alterations During Diabetes. Molecular neurobiology 6 34165684
2016 Olig1 expression pattern in neural cells during rat spinal cord development. Neuropsychiatric disease and treatment 5 27143892
2008 Olig1 is downregulated in oligodendrocyte progenitor cell differentiation. Neuroreport 4 18628665
2025 Olig1/2 Drive Astrocytic Glioblastoma Proliferation Through Transcriptional Co-Regulation of Various Cyclins. Genes 3 40428395
2025 Olig1/2 Orchestrates Progenitor Cell Fates during Mammalian Cortical Gliogenesis and Gliomagenesis. Nature communications 3 41193423
2016 Predominant neuronal differentiation of Olig1+ neural progenitors in forebrain cortex biased by β-catenin over-expression. Neuroscience letters 3 27084689
2007 Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2 17171653
2024 Comparative transcriptomic profiling reveals a role for Olig1 in promoting axon regeneration. Cell reports 1 39002126
2014 [Effect of Yishen Daluo Decoction on the expression of PLP, Olig1, and Olig2 in mice with experimental autoimmune encephalomyelitis]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 1 24941845

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