Affinage

NXF2

Nuclear RNA export factor 2 · UniProt Q9GZY0

Length
626 aa
Mass
71.6 kDa
Annotated
2026-06-10
49 papers in source corpus 19 papers cited in narrative 19 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NXF2 is a member of the nuclear RNA export factor family that operates as a sequence- and context-selective mRNA export receptor, having diverged from the bulk-export role of NXF1 toward specialized regulatory functions in the germline, neurons, and—in Drosophila—transposon silencing (PMID:11073998, PMID:11780633, PMID:15175155). Through a conserved NTF2-like domain it heterodimerizes with the p15 cofactors NXT1/NXT2, and through a ubiquitin-associated domain it contacts the FG-repeats of nucleoporins, an arrangement that supports nuclear-envelope localization and export of otherwise inefficiently exported transcripts (PMID:11073998, PMID:15820316); the crystal structure of the NTF2-domain/NXT1 complex shows that p15 binding directly licenses nucleoporin engagement, with a Nup-binding pocket formed at the heterodimer interface (PMID:22123199). Unlike NXF1, NXF2 does not drive bulk poly(A)+ RNA export and instead acts on defined substrates: in C. elegans it binds the TRE element of the tra-2 3'UTR and routes that mRNA away from NXF1-dependent export, partitioning between a nuclear-periphery granule pool and the cytoplasm in a CRM1/XPO-1-dependent manner across the germline (PMID:15175155, PMID:35950937). In mammals NXF2 is required for spermatogenesis, with knockout mice showing meiotic arrest and failure to maintain spermatogonial stem cells (PMID:19345203), and in neurons it couples to the kinesin KIF17 to form motile dendritic RNP granules and collaborates with FMRP to destabilize Nxf1 mRNA (PMID:17403691, PMID:17548835). In Drosophila, NXF2 has been co-opted as the RNA-binding subunit of the SFiNX/PICTS complex with Panoramix, Nxt1/p15, and the dynein light chain LC8/Cut-up, where it directly binds nascent transposon transcripts in a Piwi-dependent manner to initiate co-transcriptional heterochromatin silencing, deposition of H3K9me3, and tethering of target loci to the nuclear lamina (PMID:31384064, PMID:31219034, PMID:31368590, PMID:33538693, PMID:34337769).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2000 High

    Established NXF2 as a bona fide member of the NXF export-receptor family by showing it binds RNA, localizes to the nuclear envelope, has RNA export activity, and uses conserved NTF2-like and UBA domains to bind p15 and nucleoporins.

    Evidence RNA export assay, fluorescence localization, and p15/NXT binding assays in human cells

    PMID:11073998

    Open questions at the time
    • Did not define which transcripts NXF2 selectively exports versus NXF1
    • No in vivo or tissue-specific role established
  2. 2001 High

    Distinguished NXF2 from NXF1 functionally by showing Drosophila Nxf2 is dispensable for bulk mRNA export, pointing to a specialized rather than housekeeping role.

    Evidence RNAi depletion and poly(A)+ FISH in Drosophila cells

    PMID:11780633

    Open questions at the time
    • Did not identify the specialized substrates or pathway NXF2 acts in
    • Negative result does not exclude tissue-specific export roles
  3. 2004 High

    Defined the first specific NXF2 substrate and a regulatory logic: rather than exporting mRNA, C. elegans NXF-2 binds the tra-2 3'UTR TRE element to block NXF-1 export and reroute the transcript through CRM1.

    Evidence RNA-binding assay, genetic epistasis, and leptomycin B inhibition in C. elegans

    PMID:15175155

    Open questions at the time
    • Whether mammalian NXF2 uses analogous 3'UTR-element recognition unknown
    • Structural basis of TRE recognition not defined
  4. 2005 High

    Confirmed mammalian NXF2 as an active, paralog-distinct export receptor by demonstrating FG-nucleoporin binding, p15/NXT1 heterodimerization, and export of an inefficient substrate, while related NXF3/NXF7 lack these activities.

    Evidence Localization, GST pulldown, Co-IP, and mRNA export reporter assays in mouse cells with developmental expression profiling

    PMID:15820316 PMID:16027110

    Open questions at the time
    • Endogenous mammalian NXF2 cargoes not identified
    • Functional significance of brain expression not addressed at this stage
  5. 2006 Medium

    Linked NXF2 to FMRP biology by showing FMRP associates specifically with NXF2 and not NXF1 in germ cells and neurons, nominating a tissue-specific regulatory partnership.

    Evidence Co-immunoprecipitation from mouse brain and testis

    PMID:16790844

    Open questions at the time
    • Single Co-IP from tissue without reciprocal mapping of the interaction interface
    • Functional consequence of the FMRP–NXF2 association not yet shown
  6. 2007 High

    Resolved a neuronal function for NXF2: it links to the kinesin KIF17 for bidirectional dendritic mRNP transport and, with FMRP, destabilizes Nxf1 mRNA, establishing NXF2 as a post-transcriptional regulator of its own paralog.

    Evidence Y2H, GST pulldown, Co-IP, live-cell granule imaging, mRNP IP-RT-PCR, and Fmr1 siRNA rescue in neuronal cells

    PMID:17403691 PMID:17548835

    Open questions at the time
    • Mechanism by which the NXF2/FMRP complex triggers Nxf1 mRNA decay not defined
    • Full transcript set transported in dendritic granules unknown
  7. 2009 High

    Demonstrated an essential in vivo requirement for NXF2 in the germline, separating roles in meiotic progression and spermatogonial stem cell maintenance.

    Evidence Nxf2-null mouse with histology, proliferation, and motility readouts across two genetic backgrounds

    PMID:19345203

    Open questions at the time
    • Molecular cargoes or targets underlying the spermatogenic defect not identified
    • Whether the phenotype reflects export, mRNA stability, or another activity unresolved
  8. 2010 Medium

    Identified NXF2 as a Taspase1 protease substrate, raising the possibility of regulated proteolytic processing of the export factor.

    Evidence Cell-based translocation biosensor, scanning mutagenesis, and full-length cleavage verification

    PMID:21084304

    Open questions at the time
    • Functional consequence of cleavage for export or other activities not established
    • Single lab, single study
  9. 2011 High

    Provided the structural basis for NXF2 heterodimer assembly and export licensing, showing the NTF2/NXT1 interface itself forms a nucleoporin-binding pocket so that p15 binding directly gates Nup engagement.

    Evidence X-ray crystallography of the ceNXF2 NTF2 domain bound to ceNXT1 with interface mutagenesis and nuclear-envelope colocalization

    PMID:22123199

    Open questions at the time
    • Structure of the RNA-binding and UBA regions not solved
    • Whether the predicted phosphoregulation site is used in vivo unknown
  10. 2012 Medium

    Reported an unexpected mitotic function in tumor cells, where NXF2 depletion disrupts spindle integrity and chromosome segregation.

    Evidence siRNA knockdown with spindle immunofluorescence, mitotic live imaging, and microtubule cytaster assays in NSCLC cells

    PMID:22869527

    Open questions at the time
    • Mechanistic link between RNA export activity and spindle/microtubule control not defined
    • Single lab, single study; function atypical for an NXF protein
  11. 2019 High

    Redefined Drosophila Nxf2 as the RNA-binding arm of the SFiNX/Panx-Nxf2-p15 complex, showing it directly binds nascent transposon transcripts Piwi-dependently and that RNA-tethering of Nxf2 is sufficient to initiate co-transcriptional silencing, with Panoramix recruiting heterochromatin effectors and the two proteins stabilizing each other.

    Evidence Co-IP, λN/BoxB tethering, ChIP for H3K9me3/H1, genetic knockouts, protein stability and domain-mapping assays across three independent labs

    PMID:31219034 PMID:31368590 PMID:31384064

    Open questions at the time
    • How Nxf2 'licenses' silencing mechanistically beyond RNA tethering not resolved
    • Whether mammalian NXF2 has any analogous chromatin-silencing role unknown
  12. 2021 High

    Extended the silencing model by showing the dynein light chain LC8/Cut-up dimerizes the PICTS complex—dimerization being its essential function—and that Nxf2/Piwi drive recruitment of target loci to the nuclear lamina and reorganize TAD architecture.

    Evidence Co-IP, knockouts, tethering, artificial dimerization rescue, ChEP, DamID-seq, and Hi-C in Drosophila

    PMID:33538693 PMID:34337769

    Open questions at the time
    • Structural geometry of the dimerized complex on chromatin not solved
    • Causal order between lamina tethering and chromatin mark deposition not fully resolved
  13. 2022 High

    Refined the germline export model in C. elegans, showing NXF-2 forms nuclear-periphery granules in the mitotic gonad in a CRM1/XPO-1-dependent manner and is required for tra-2 mRNA export via its 3'UTR.

    Evidence Live imaging of granules, CRM1 inhibition, NES mutation, and RNAi with reporter export assay in C. elegans gonad

    PMID:35950937

    Open questions at the time
    • Composition of the NXF-2 granules not defined
    • How granule release in the meiotic region is triggered unknown
  14. 2025 Medium

    Reaffirmed NXF2's role in the human testis export machinery by demonstrating an in vivo NXT2 interaction mediated by NXT2's NTF2-like domain.

    Evidence Co-immunoprecipitation and domain binding assay from human testis

    PMID:40624043

    Open questions at the time
    • Endogenous human testis cargoes of NXF2 not identified
    • Single study with reciprocal Co-IP but no functional export readout in human tissue

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unknown whether mammalian NXF2 possesses a chromatin-silencing or transposon-control activity analogous to the Drosophila SFiNX/PICTS pathway, and what the endogenous RNA cargoes are that underlie its germline and neuronal requirements.
  • No mammalian Panoramix ortholog or equivalent silencing complex defined in the corpus
  • Direct endogenous cargo transcripts of mammalian NXF2 not catalogued

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 4 GO:0005215 transporter activity 4 GO:0060090 molecular adaptor activity 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005635 nuclear envelope 4 GO:0005829 cytosol 3 GO:0000228 nuclear chromosome 2 GO:0005634 nucleus 2
Pathway
R-HSA-4839726 Chromatin organization 3 R-HSA-8953854 Metabolism of RNA 3 R-HSA-9609507 Protein localization 3 R-HSA-1474165 Reproduction 1
Partners
FMRPKIF17LC8/CUT-UPNXT1NXT2PANORAMIXPIWISTAUFEN1
Complex memberships
NXF2/NXT1 (p15) heterodimerSFiNX/PICTS complex (Panoramix-Nxf2-Nxt1/p15-LC8/Cut-up)

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 NXF2 binds RNA, localizes to the nuclear envelope, and exhibits RNA export activity. Both human p15 homologues (NXT1 and NXT2) bind NXF2. The NTF2-like domain mediating heterodimerization with p15 and the ubiquitin-associated domain mediating nucleoporin interaction are conserved in NXF2. Functional RNA export assay, subcellular localization by fluorescence microscopy, binding assays for p15 interaction Molecular and cellular biology High 11073998
2001 Depletion of Drosophila NXF2 (Dm NXF2) has no apparent phenotype on bulk mRNA export in cultured Drosophila cells, in contrast to NXF1/p15 depletion which causes robust nuclear accumulation of poly(A)+ RNA, indicating Dm NXF2 is not required for general mRNA export. RNAi depletion in Drosophila cells, fluorescence in situ hybridization for poly(A)+ RNA RNA (New York, N.Y.) High 11780633
2004 C. elegans NXF-2 (CeNXF-2) specifically binds the TRE element of the tra-2 mRNA 3'UTR and inhibits its export via NXF-1, routing it instead through a CRM1-dependent pathway; removal of CeNXF-2 results in export of tra-2 via NXF-1. RNA binding assay (TRE element binding), genetic epistasis (NXF-2 loss-of-function), CRM1 inhibition with leptomycin B Molecular cell High 15175155
2005 Mouse NXF2 localizes to the nucleus and nuclear envelope, binds phenylalanine-glycine (FG) repeat sequences of nucleoporins, heterodimerizes with p15/NXT1, and enhances nuclear export of an otherwise inefficiently exported mRNA substrate. Mouse NXF3 does not bind FG repeats and lacks mRNA export activity. GFP-tagging/subcellular localization, GST pulldown for nucleoporin binding, co-immunoprecipitation with p15/NXT1, mRNA export reporter assay Genomics High 15820316
2005 Mouse NXF2 is an active mRNA export receptor expressed during brain development; it localizes to the nucleus, nuclear envelope, and cytoplasm. Mouse NXF7 localizes exclusively to cytoplasmic granules and lacks mRNA export activity despite conserved sequence. GFP-tagged protein localization, mRNA export activity assay, Western blot developmental expression analysis Nucleic acids research Medium 16027110
2006 FMRP associates specifically with NXF2 but not with its close relative NXF1 in mouse male germ cells and hippocampal neurons, as shown by co-immunoprecipitation. Co-immunoprecipitation from brain and testis tissue RNA (New York, N.Y.) Medium 16790844
2007 NXF2 interacts with the cytoplasmic motor protein KIF17 via its N-terminal domain; this interaction is required for the punctate localization of NXF2 in dendrites. NXF2-containing dendritic granules co-localize with KIF17, mRNA, and Staufen1, and move bidirectionally along dendrites in a microtubule-dependent manner. Yeast two-hybrid screening, GST pulldown, co-immunoprecipitation, live-cell fluorescence imaging of dendritic granule motility, domain deletion mapping Nucleic acids research High 17403691
2007 In neuronal cells, both FMRP and NXF2 are present in Nxf1 mRNA-containing ribonucleoprotein particles; expression of NXF2 destabilizes Nxf1 mRNA, and this effect is abolished when Fmr1 is reduced by siRNA, demonstrating that FMRP and NXF2 collaborate to destabilize Nxf1 mRNA. Immunoprecipitation of mRNPs, quantitative RT-PCR, siRNA knockdown of Fmr1 Proceedings of the National Academy of Sciences of the United States of America High 17548835
2009 Nxf2 null male mice exhibit meiotic arrest and/or reduced spermatogonial proliferation depending on genetic background; inactivation causes depletion of germ cells with age, demonstrating dual roles for Nxf2 in regulation of meiosis and maintenance of spermatogonial stem cells in vivo. Targeted gene deletion (homologous recombination in ES cells), histology, sperm motility analysis, BrdU proliferation assay Developmental biology High 19345203
2010 NXF2 is cleaved by Taspase1 threonine protease; bioinformatic identification followed by experimental verification using biosensor and full-length protein cleavage assays confirmed NXF2 as a bona fide Taspase1 substrate. Cell-based translocation biosensor assay, scanning mutagenesis, cleavage site verification for full-length NXF2 The Journal of biological chemistry Medium 21084304
2011 The crystal structure of C. elegans NXF2 (ceNXF2) NTF2 domain bound to ceNXT1 revealed contacts crucial for heterodimer stability and specificity, including a probable phosphoregulation site; the ceNXF2/ceNXT1 complex has at least two nucleoporin (Nup) binding pockets, one of which is formed at the heterodimer interface, demonstrating that NXT1 binding directly regulates NXF2's interaction with nucleoporins. X-ray crystallography, mutagenesis of interface residues, functional colocalization assay at nuclear envelope Journal of molecular biology High 22123199
2012 NXF2 is required for accurate chromosome segregation in tumor cells; its depletion in non-small-cell lung cancer cells enhances multipolar spindle formation, increases mitotic transit time, induces micronucleation upon paclitaxel treatment, and disrupts microtubule stability/cytaster formation. siRNA knockdown, immunofluorescence for spindle morphology, live-cell imaging of mitosis, microtubule cytaster assay Molecular and cellular biology Medium 22869527
2019 Drosophila Nxf2 forms the SFiNX complex with Panoramix (Panx) and Nxt1; this complex is required for Piwi-mediated co-transcriptional silencing of transposons. Nxf2 directly binds nascent transposon transcripts in a Piwi-dependent manner, and tethering Nxf2 to RNA is sufficient to silence target loci and accumulate repressive chromatin marks. Within the complex, Panoramix recruits heterochromatin effectors while Nxf2 licenses co-transcriptional silencing. Nxf2 and Panx are mutually required for each other's protein stability and localization. Co-immunoprecipitation, tethering assay (λN/BoxB system), ChIP for H3K9me3, genetic knockout (sterility/transposon derepression), protein stability assays, direct RNA binding Nature structural & molecular biology High 31219034 31368590 31384064
2019 Nxf2 forms a complex with Piwi and Panx (Panx-Nxf2-p15); ectopic targeting of Nxf2 initiates co-transcriptional repression independently of H3K9me3 or H1, but continuous silencing requires HP1a and H1. Panx-Nxf2-p15 complex formation stabilizes Nxf2 and Panx protein levels. Co-immunoprecipitation, tethering reporter assay, ChIP for H3K9me3 and H1, genetic epistasis with HP1a/H1 mutants The EMBO journal High 31368590
2019 The N-terminal portion of Panoramix is sufficient to induce transcriptional silencing; Nxf2 and Panx proteins are mutually required for proper localization and stability. Domain mapping identified the protein domains crucial for Nxf2/Panx complex formation. Domain deletion/truncation analysis, co-immunoprecipitation, protein stability assays, tethering reporter assay eLife High 31219034
2021 The dynein light chain LC8/Cut-up (Ctp) is an essential component of the PICTS complex (containing Panoramix, Nxf2, and Nxt1); Ctp drives dimerisation of the PICTS complex through interaction with conserved motifs in Panoramix, and artificial dimerisation of Panoramix bypasses the need for Ctp, demonstrating dimerisation is the key function of Ctp in this silencing complex. Co-immunoprecipitation, genetic knockout (transposon derepression, loss of H3K9me3), tethering assay, artificial dimerization rescue experiment eLife High 33538693
2021 Piwi/Nxf2-dependent recruitment of piRNA target loci to nuclear lamins was demonstrated; depletion of Piwi or Nxf2 decreases intra-TAD and increases inter-TAD interactions at TE-harboring regions, indicating Nxf2 participates in nuclear architectural changes required for transcriptional silencing. ChEP (chromatin enrichment for proteomics), DamID-seq for lamin association, Hi-C chromatin conformation capture, forced tethering system The EMBO journal High 34337769
2022 C. elegans NXF-2 is specifically expressed in germ cells and forms a novel granular structure anchored to the nuclear periphery in the mitotic region of the gonad via XPO-1/CRM1-dependent activity; in the meiotic region NXF-2 granules are released to the cytoplasm. Inhibition of NXF-2 causes nuclear accumulation of tra-2 3'UTR-containing reporter mRNA, demonstrating NXF-2 is required for export of tra-2 mRNA via its 3'UTR. Immunofluorescence/live imaging for granule localization, CRM1 inhibition (leptomycin B equivalent), NES mutation, RNAi knockdown with reporter mRNA export assay Genes to cells : devoted to molecular & cellular mechanisms High 35950937
2025 NXT2 binds NXF2 in vivo in human testis; this interaction is mediated by the NTF2-like domain of NXT2. NXF2 thus participates in the nuclear RNA export machinery as an NXT2-binding partner in the human testis. Co-immunoprecipitation (in vivo interaction), domain binding assay (NTF2-like domain of NXT2) Nature communications Medium 40624043

Source papers

Stage 0 corpus · 49 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. Molecular and cellular biology 173 11073998
2017 Oncogenic roles of DNA hypomethylation through the activation of cancer-germline genes. Cancer letters 159 28342986
2001 NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila. RNA (New York, N.Y.) 144 11780633
2011 Multiple cancer/testis antigens are preferentially expressed in hormone-receptor negative and high-grade breast cancers. PloS one 81 21437249
2019 The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation. Nature structural & molecular biology 80 31384064
2019 piRNA-guided co-transcriptional silencing coopts nuclear export factors. eLife 70 31219034
2012 Multiple cancer testis antigens function to support tumor cell mitotic fidelity. Molecular and cellular biology 67 22869527
2007 Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells. Proceedings of the National Academy of Sciences of the United States of America 66 17548835
2019 Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing. The EMBO journal 65 31368590
1996 Patient isolates of Borrelia burgdorferi sensu lato with genotypic and phenotypic similarities of strain 25015. The Journal of infectious diseases 63 8896519
2001 NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. Current biology : CB 61 11566096
2003 Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia. International journal of cancer 59 12704671
2009 Inactivation of Nxf2 causes defects in male meiosis and age-dependent depletion of spermatogonia. Developmental biology 48 19345203
2009 Treatment of chronic lymphocytic leukemia with a hypomethylating agent induces expression of NXF2, an immunogenic cancer testis antigen. Clinical cancer research : an official journal of the American Association for Cancer Research 45 19401350
2010 Cell-based analysis of structure-function activity of threonine aspartase 1. The Journal of biological chemistry 43 21084304
2009 Male infertility and the involvement of the X chromosome. Human reproduction update 41 19515807
2007 NXF2 is involved in cytoplasmic mRNA dynamics through interactions with motor proteins. Nucleic acids research 41 17403691
2009 Regulation of male fertility by X-linked genes. Journal of andrology 39 19875494
2006 The fragile X mental retardation protein interacts with a distinct mRNA nuclear export factor NXF2. RNA (New York, N.Y.) 39 16790844
2004 NXF-2, REF-1, and REF-2 affect the choice of nuclear export pathway for tra-2 mRNA in C. elegans. Molecular cell 37 15175155
2021 Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila. eLife 36 33538693
2011 Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma. Human reproduction (Oxford, England) 36 22016418
2012 The kinesin superfamily protein KIF17: one protein with many functions. Biomolecular concepts 35 23762210
2005 Molecular cloning and functional characterization of mouse Nxf family gene products. Genomics 33 15820316
2013 Cancer-testis antigen expression in digestive tract carcinomas: frequent expression in esophageal squamous cell carcinoma and its precursor lesions. Cancer immunology research 29 24795360
2005 Identification and characterization of the mouse nuclear export factor (Nxf) family members. Nucleic acids research 28 16027110
1995 Genotypic and phenotypic characterization of Borrelia burgdorferi isolated from ticks and small animals in Illinois. Journal of clinical microbiology 24 7494019
2013 Expression of cancer/testis (CT) antigens in squamous cell carcinoma of the head and neck: evaluation as markers of squamous dysplasia. Pathology, research and practice 21 24011616
2021 Piwi-piRNA complexes induce stepwise changes in nuclear architecture at target loci. The EMBO journal 20 34337769
2010 Familial 1.1 Mb deletion in chromosome Xq22.1 associated with mental retardation and behavioural disorders in female patients. European journal of medical genetics 20 20096387
2003 Inv(X)(p21.1;q22.1) in a man with mental retardation, short stature, general muscle wasting, and facial dysmorphism: clinical study and mutation analysis of the NXF5 gene. American journal of medical genetics. Part A 20 12784308
2007 The role of spermatogonially expressed germ cell-specific genes in mammalian meiosis. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 19 17674150
2011 The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold. Journal of molecular biology 18 22123199
2011 Nxf3 is expressed in Sertoli cells, but is dispensable for spermatogenesis. Molecular reproduction and development 13 21308854
2011 De novo duplication of Xq22.1→q24 with a disruption of the NXF gene cluster in a mentally retarded woman with short stature and premature ovarian failure. Taiwanese journal of obstetrics & gynecology 13 22030050
2008 Is there a role for the nuclear export factor 2 gene in male infertility? Fertility and sterility 13 18258234
2013 A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice. Biology of reproduction 12 23677977
2014 Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome. Human molecular genetics 11 24569167
2016 Copy number gain of VCX, X-linked multi-copy gene, leads to cell proliferation and apoptosis during spermatogenesis. Oncotarget 10 27705943
2020 Telomeric TART elements target the piRNA machinery in Drosophila. PLoS biology 9 33347429
2013 Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability. PloS one 9 23675524
2009 [Genetics and male infertility]. Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 8 20088251
2022 Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis. PLoS genetics 7 35192609
2016 Discovery of piperonal-converting oxidase involved in the metabolism of a botanical aromatic aldehyde. Scientific reports 6 27905507
2013 The cancer‑testis antigen NXF2 is activated by the hypomethylating agent decitabine in acute leukemia cells in vitro and in vivo. Molecular medicine reports 6 24002123
2022 Safeguarding Drosophila female germ cell identity depends on an H3K9me3 mini domain guided by a ZAD zinc finger protein. PLoS genetics 3 36548300
2010 [Sex chromosomes and male infertility]. Zhonghua nan ke xue = National journal of andrology 1 20684331
2025 NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis. Nature communications 0 40624043
2022 The germ cell-specific TAP-like protein NXF-2 forms a novel granular structure and is required for tra-2 3'UTR-dependent mRNA export in Caenorhabditis elegans. Genes to cells : devoted to molecular & cellular mechanisms 0 35950937

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