Affinage

NFYB

Nuclear transcription factor Y subunit beta · UniProt P25208

Length
207 aa
Mass
22.8 kDa
Annotated
2026-06-10
60 papers in source corpus 22 papers cited in narrative 22 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NFYB (NF-YB/CBF-A/HAP3) is the histone-fold subunit of the evolutionarily conserved heterotrimeric NF-Y/CCAAT-binding transcription factor, a complex first defined in yeast where HAP3 and HAP2 bind interdependently to the CCAAT element of CYC1 and pre-assemble into a multisubunit complex independent of DNA (PMID:2826015, PMID:2832951). The mammalian subunit CBF-A is the direct ortholog of HAP3, with a deeply conserved core (PMID:2266139). NFYB heterodimerizes with NF-YC through their histone-fold motifs, generating a tridentate surface that recruits NF-YA to form the trimer competent for CCAAT-element binding (PMID:7878029, PMID:8754798); the crystal structure of the NF-YB/NF-YC subcomplex shows these histone folds are closely related to H2A/H2B and NC2 (PMID:12401788). NFYB additionally contacts the general transcription machinery, interacting directly with TBP and associating with TFIID to couple CCAAT recognition to transcription initiation (PMID:9153318). Through this promoter-binding activity NFYB acts as a transcriptional activator across diverse target genes, transactivating E2F1 and contributing to a pro-survival, chemoresistance-promoting program in cancer cells (PMID:26039627, PMID:29203250), and binding the promoters of HDAC5, MBTD1, and STK33 in additional resistance contexts (PMID:36434485, PMID:37742129). Its recruitment and output are modulated by partner proteins including Dysbindin at the MARCKS promoter (PMID:20098743) and IER5, which represses Cdc25B by triggering release of the p300 coactivator from NF-YB (PMID:22132193, PMID:34484679). Beyond its transcriptional role, the C. elegans ortholog NFYB-1 maintains mitochondrial function and cardiolipin levels by repressing lysosomal prosaposin (PMID:32694663).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1988 High

    Established that the NFYB ortholog HAP3 is an essential gene product that cannot bind CCAAT DNA alone but must partner with HAP2, defining NF-Y as an obligate heteromeric DNA-binding factor.

    Evidence Gel-shift, footprinting, and chromosomal disruption/complementation with tagged HAP2/HAP3 fusions in yeast

    PMID:2826015 PMID:2832732

    Open questions at the time
    • Did not resolve which residues mediate the protein-protein interaction
    • Mammalian subunit composition not yet defined
  2. 1988 High

    Showed that HAP2 and HAP3 pre-assemble into a stable complex in the absence of DNA, indicating subunit dimerization precedes DNA engagement.

    Evidence Co-purification of LexA-HAP2 and HAP3-beta-galactosidase fusions through four chromatographic steps

    PMID:2832951

    Open questions at the time
    • Did not identify additional subunits required for full activation
    • Structural basis of association unknown
  3. 1990 High

    Connected the yeast and mammalian systems by demonstrating that mammalian CBF-A is the histone-fold-bearing ortholog of HAP3, establishing evolutionary conservation of the NFYB subunit.

    Evidence DNA affinity purification, tryptic peptide sequencing, and cDNA cloning of mammalian CBF

    PMID:2266139

    Open questions at the time
    • Full mammalian trimer composition not yet reconstituted
    • Conserved residues mediating dimerization not mapped
  4. 1996 High

    Defined the assembly logic of the mammalian trimer: NF-YB and NF-YC dimerize via histone-fold motifs to create the surface that recruits NF-YA, answering how the three subunits combine to bind CCAAT.

    Evidence Recombinant reconstitution, EMSA, cross-linking, yeast two-hybrid, and mutational mapping in rat/human subunits

    PMID:7878029 PMID:8754798

    Open questions at the time
    • Atomic-resolution interface not yet defined
    • DNA-bound conformation unresolved
  5. 1997 High

    Linked NFYB to the basal transcription machinery by showing direct NF-YB/NF-YC contacts with TBP and association with TFIID, providing a route from CCAAT recognition to initiation.

    Evidence Holo-TFIID immunopurification, sedimentation velocity, and domain-mapped in vitro interaction assays

    PMID:9153318

    Open questions at the time
    • Functional consequence on initiation rate not quantified in vivo
    • Competition with NC2 at TBP not fully resolved
  6. 2002 High

    Provided the structural basis of NF-YB/NF-YC interaction, showing histone folds related to H2A/H2B and a regulatory alphaC helix targeted by factors such as MYC and p53.

    Evidence X-ray crystallography of the NF-YB/NF-YC subcomplex with modeling of the CCAAT complex

    PMID:12401788

    Open questions at the time
    • Structure of the full DNA-bound trimer not solved here
    • Dynamics of regulatory protein recruitment not captured
  7. 2010 Medium

    Identified NFYB as a partner of Dysbindin at a specific CCAAT-containing promoter, extending its role to neuronal gene regulation (MARCKS).

    Evidence Yeast two-hybrid, co-IP, ChIP, and reporter/knockdown assays in mouse brain

    PMID:20098743

    Open questions at the time
    • Single lab
    • Whether Dysbindin acts within the full NF-Y trimer not established
  8. 2021 Medium

    Showed NFYB output can be negatively regulated through coactivator release, with IER5 displacing p300 from NF-YB at the Cdc25B promoter.

    Evidence Reporter assays, promoter mutagenesis, and ChIP in AML progenitors and irradiated HeLa cells

    PMID:22132193 PMID:34484679

    Open questions at the time
    • Single lab series
    • Direct biochemical p300/NF-YB displacement not reconstituted
  9. 2017 Medium

    Placed NFYB in a pro-survival/chemoresistance program by demonstrating it transactivates E2F1 (itself an upstream regulator of NFYB), feeding a CHK1 axis that suppresses drug-induced apoptosis.

    Evidence Knockdown/overexpression, transcriptomics, reporter assays, and in vitro/in vivo tumor assays in colorectal cancer

    PMID:26039627 PMID:29203250

    Open questions at the time
    • Single lab per finding
    • Direct ChIP occupancy at E2F1 promoter not shown in both studies
  10. 2023 Medium

    Expanded the activator target repertoire of NFYB to HDAC5, MBTD1, and STK33 in distinct cancer chemoresistance settings.

    Evidence ChIP/ChIP-qPCR, luciferase reporters, knockdown/overexpression, and metabolic/proliferation assays in lymphoma and glioma cells

    PMID:34536775 PMID:36434485 PMID:37742129

    Open questions at the time
    • Each target shown by a single lab
    • Whether targets require the full NF-Y trimer vs NFYB alone not dissected
  11. 2020 High

    Revealed a non-canonical organismal role for the NFYB ortholog: NFYB-1 represses lysosomal prosaposin to maintain mitochondrial cardiolipin, oxygen consumption, and stress-pathway integrity.

    Evidence RNAi screens, multi-omics, oxygen consumption, mitochondrial morphology imaging, and cardiolipin rescue in C. elegans

    PMID:32694663

    Open questions at the time
    • Whether mammalian NFYB performs an equivalent mitochondrial function not shown
    • Direct prosaposin promoter occupancy not established
  12. 2025 Medium

    Positioned NFYB as a cooperative dependency with menin-MLL1, with NF-Y pioneer recruitment associated with chromatin opening after menin inhibition.

    Evidence Epigenome-focused CRISPR screen and chromatin accessibility assays with menin inhibitor in HCC cells (preprint)

    PMID:bio_10.1101_2025.04.05.647381

    Open questions at the time
    • Preprint, single lab
    • Direct physical link between NF-Y and menin-MLL1 not demonstrated

Open questions

Synthesis pass · forward-looking unresolved questions
  • How NFYB's canonical CCAAT/initiation role mechanistically connects to its mitochondrial/cardiolipin regulatory function, and whether this is conserved in mammals, remains unresolved.
  • No mammalian study links NFYB to prosaposin or cardiolipin
  • Genome-wide direct target map integrating both roles is absent

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 4 GO:0003677 DNA binding 3 GO:0042393 histone binding 1 GO:0140223 general transcription initiation factor activity 1
Localization
GO:0005634 nucleus 3
Pathway
R-HSA-74160 Gene expression (Transcription) 4
Partners
DTNBP1E2F1IER5NFYANFYCTBP
Complex memberships
NF-Y / CBF (CCAAT-binding factor) heterotrimerTFIID

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1987 HAP3 (yeast ortholog of NFYB) and HAP2 bind interdependently to the CCAAT-containing UAS2 of CYC1; neither protein binds DNA alone, and binding of either is abolished when the complementary HAP gene is mutated, demonstrating that they form a heteromeric DNA-binding complex. Nondenaturing PAGE gel shift with beta-galactosidase and LexA fusion proteins; methylation interference footprinting; in vitro DNA binding with yeast extracts Cell High 2826015
1988 HAP2 and HAP3 associate with each other in the absence of DNA to form a multisubunit activation complex, as shown by co-purification through four chromatographic steps. Co-purification of LexA-HAP2 and HAP3-beta-galactosidase fusion proteins through four chromatographic steps; DNA binding activity co-purified with the complex Science High 2832951
1988 HAP3 encodes a 144-amino acid protein essential for UAS2 activity and growth on non-fermentable carbon sources; the 86-amino acid ORF in the antisense transcript is not involved in UAS2 activity. Chromosomal disruption, site-directed mutagenesis, in vivo complementation, reporter assays Molecular and cellular biology High 2832732
1989 HAP4 is a third subunit of the HAP2/HAP3 DNA-binding complex at UAS2; HAP4 is required for detectable HAP2/HAP3 binding in vitro and provides the principal transcriptional activation domain to the complex. Genetic analysis; in vitro DNA binding; deletion analysis of HAP4; GAL4 activation domain swap Genes & development High 2676721
1990 Mammalian CBF-A (NF-YB) is the 'A' chain of the CCAAT-binding factor (CBF) heteromer, and its deduced amino acid sequence shares remarkable identity (~90 residues) with yeast HAP3, establishing evolutionary conservation of the NFYB subunit. Protein purification by DNA affinity chromatography; tryptic peptide sequencing; cDNA cloning and in vitro transcription/translation The Journal of biological chemistry High 2266139
1993 Short regions of HAP3 (NFYB ortholog) form a hybrid DNA-binding domain with HAP2; a seven-amino-acid region in HAP3 is critical for DNA binding, and HAP3 mutations suppress multiple HAP2 DNA-binding domain mutations, indicating direct structural cooperation. Genetic mutational analysis; in vitro DNA binding; intragenic suppressor analysis The EMBO journal High 8223474
1995 Rat CBF-C (NF-YC) is required together with CBF-A (NF-YB) and CBF-B (NF-YA) to form a CBF-DNA complex; CBF-A and CBF-C interact directly with each other, and CBF-B does not interact with either subunit individually but associates with the CBF-A/CBF-C heterodimer. Recombinant protein expression; in vitro EMSA/DNA binding reconstitution; protein-protein interaction assays; cross-complementation with yeast HAP2/HAP3 Proceedings of the National Academy of Sciences of the United States of America High 7878029
1996 CBF-A (NF-YB) and CBF-C (NF-YC) interact through their histone fold motifs to form a heterodimer; this heterodimer generates a tridentate interaction surface that binds CBF-B (NF-YA) to form the heterotrimeric CBF; the evolutionarily conserved histone-fold segment of CBF-C is necessary for DNA complex formation. Cross-linking; immunoprecipitation; mutational analysis; yeast two-hybrid; in vitro DNA binding assays Molecular and cellular biology High 8754798
1997 NF-YB and NF-YC each interact directly with TBP in solution; short domains adjacent to their histone fold motifs are necessary for TBP binding; a fraction of NF-YB associates with TFIID (in the absence of NF-YA); TBP mutants in the HS2 helix defective in NC2 binding are also unable to bind NF-YB and NF-YC. Immunopurification of holo-TFIID; sedimentation velocity centrifugation; in vitro protein-protein interaction assays with truncation/domain mutants Nucleic acids research High 9153318
2002 The crystal structure of the NF-YB/NF-YC subcomplex shows that their core domains interact through histone fold motifs closely related to H2A/H2B and NC2alpha/NC2beta; the alphaC helix of NF-YC is important both for NF-Y trimerization and as a target for regulatory proteins such as MYC and p53. X-ray crystallography; structural modeling of NF-YC/NF-YB with DNA and full NF-Y/CCAAT complex The Journal of biological chemistry High 12401788
2002 MADS-box protein OsMADS18 forms a ternary complex with rice NF-YB (OsNF-YB1) via the MADS and I regions; mouse NF-YB also associates with OsMADS18 as an NF-YB/NF-YC dimer; OsNF-YB1 can heterodimerize with NF-YC but cannot trimerize with NF-YA, precluding CCAAT binding; mutation of Asp99 in the HFM alpha2-helix of OsNF-YB1 to the conserved Ser recovers NF-YA interaction but not DNA binding. Yeast two-hybrid screening; in vitro and in vivo protein-protein interaction assays; site-directed mutagenesis The Journal of biological chemistry Medium 11971906
2010 Dysbindin physically interacts with NF-YB in mouse brain; this complex binds the CCAAT motif at the MARCKS promoter and regulates MARCKS transcription; knockdown of either Dysbindin or NF-YB increases MARCKS expression. Yeast two-hybrid screening; co-immunoprecipitation; chromatin immunoprecipitation; reporter assay; DNA chip gene expression profiling PloS one Medium 20098743
2011 IER5 reduces Cdc25B mRNA expression through direct binding to the Cdc25B promoter and mediates transcriptional repression via release of NF-YB and p300 co-activator, inhibiting AML progenitor cell proliferation. Reporter assays; chromatin immunoprecipitation; gene knockdown/overexpression; colony formation assay PloS one Medium 22132193
2015 NFYB is a direct transcriptional target of E2F1; NFYB knockdown enhances E2F1-induced apoptosis, indicating that the NFYB/E2F1 joint transcriptional program has a pro-survival function. Genome-wide expression analysis; NFYB knockdown; apoptosis assays; E2F1 overexpression PloS one Medium 26039627
2017 NFYB transactivates the E2F1 gene in oxaliplatin-resistant colorectal cancer cells; the NFYB-E2F1-CHK1 axis suppresses oxaliplatin-induced apoptosis and maintains tumorigenicity in vitro and in vivo. Gene knockdown/overexpression; transcriptome profiling; in vitro and in vivo phenotype experiments; reporter assays Cancer letters Medium 29203250
2020 C. elegans NFYB-1 is a crucial regulator of mitochondrial function; its loss leads to perturbed mitochondrial gene expression, reduced oxygen consumption, mitochondrial fragmentation, disrupted mitochondrial stress pathways, and decreased cardiolipin levels. NFYB-1 acts as a repressor of lysosomal prosaposin; limiting prosaposin restores cardiolipin production and mitochondrial function in nfyb-1 mutants. RNAi screens; multi-omics analysis (transcriptomics, metabolomics); oxygen consumption assays; microscopy of mitochondrial morphology; cardiolipin supplementation rescue Nature metabolism High 32694663
2021 IER5 represses Cdc25B transcription in irradiated HeLa cells via the NF-YB binding site on the Cdc25B promoter; IER5 binds the Cdc25B promoter and induces release of the coactivator p300 through interaction with NF-YB. Dual-luciferase reporter assays; site-directed mutagenesis of promoter elements; chromatin immunoprecipitation (ChIP); irradiation model Toxicology research Medium 34484679
2021 NFYB can bind to the STK33 promoter and promote STK33 expression, thereby activating the Hedgehog signaling pathway and promoting cisplatin resistance in DLBCL cells. Bioinformatics prediction; luciferase reporter assay; gene knockdown; cell sensitivity assays Leukemia research Low 34536775
2022 H19 lncRNA recruits NFYB to the MBTD1 promoter to activate MBTD1 transcription, promoting doxorubicin resistance in lymphoma cells; H19 increases MBTD1 expression in a NFYB-dependent manner without altering NFYB levels. Luciferase reporter assay; ChIP-qPCR; gene knockdown and overexpression; in vitro and in vivo growth assays Molecular biotechnology Medium 36434485
2023 NFYB activates HDAC5 transcription by binding to the HDAC5 promoter; HDAC5 in turn inhibits SHMT2 expression, reducing glycolysis and increasing TMZ sensitivity in GBM cells. Chromatin immunoprecipitation; dual-luciferase reporter assay; gene overexpression/knockdown; glucose uptake and lactate production assays; proliferation and apoptosis assays Journal of neuropathology and experimental neurology Medium 37742129
2024 Coptisine downregulates E2F7 in HCC by inhibiting E2F4/NF-YA/NF-YB transcription factor activity at the E2F7 promoter, as confirmed by promoter fragmentation experiments and ChIP. Promoter fragmentation experiments; chromatin immunoprecipitation; RNA-Seq; in vitro and in vivo HCC growth assays Chemico-biological interactions Medium 38795876
2025 NFYB knockout combined with menin-MLL1 inhibition causes significantly increased HCC cell death; menin inhibition increases chromatin accessibility at sites not bound by menin-MLL1 that are associated with NF-Y pioneer factor recruitment, placing NFYB in a cooperative oncogenic gene regulation pathway with menin-MLL1. CRISPR/Cas9 screen; epigenome-focused CRISPR library screen in 2D and 3D HCC cell lines; chromatin accessibility assays; menin inhibitor (SNDX-5613) treatment bioRxivpreprint Medium bio_10.1101_2025.04.05.647381

Source papers

Stage 0 corpus · 60 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1989 Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer. Genes & development 349 2676721
1995 Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proceedings of the National Academy of Sciences of the United States of America 253 7878029
2002 The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. The Journal of biological chemistry 235 12401788
1987 Yeast HAP2 and HAP3 activators both bind to the CYC1 upstream activation site, UAS2, in an interdependent manner. Cell 211 2826015
1993 Mutations in yeast HAP2/HAP3 define a hybrid CCAAT box binding domain. The EMBO journal 136 8223474
1996 Determination of functional domains in the C subunit of the CCAAT-binding factor (CBF) necessary for formation of a CBF-DNA complex: CBF-B interacts simultaneously with both the CBF-A and CBF-C subunits to form a heterotrimeric CBF molecule. Molecular and cellular biology 130 8754798
2017 CONSTANS Imparts DNA Sequence Specificity to the Histone Fold NF-YB/NF-YC Dimer. The Plant cell 129 28526714
1988 Mutational analysis of upstream activation sequence 2 of the CYC1 gene of Saccharomyces cerevisiae: a HAP2-HAP3-responsive site. Molecular and cellular biology 119 2832731
1988 Yeast HAP2 and HAP3: transcriptional activators in a heteromeric complex. Science (New York, N.Y.) 115 2832951
1988 The HAP3 regulatory locus of Saccharomyces cerevisiae encodes divergent overlapping transcripts. Molecular and cellular biology 108 2832732
1997 CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues. Nucleic acids research 103 9153318
2002 Ternary complex formation between MADS-box transcription factors and the histone fold protein NF-YB. The Journal of biological chemistry 87 11971906
1990 Purification and molecular cloning of the "A" chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor. The Journal of biological chemistry 83 2266139
2020 Structural Insight into DNA Recognition by CCT/NF-YB/YC Complexes in Plant Photoperiodic Flowering. The Plant cell 71 32843433
2007 The tetraplex (CGG)n destabilizing proteins hnRNP A2 and CBF-A enhance the in vivo translation of fragile X premutation mRNA. Nucleic acids research 66 17716999
2017 NFYB-induced high expression of E2F1 contributes to oxaliplatin resistance in colorectal cancer via the enhancement of CHK1 signaling. Cancer letters 61 29203250
2000 Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF - a model for overcoming inhibition of proliferation by CBF oncoproteins. Oncogene 51 10851069
2024 Unraveling the intricacies of glioblastoma progression and recurrence: insights into the role of NFYB and oxidative phosphorylation at the single-cell level. Frontiers in immunology 48 38510250
2008 Duplication and functional diversification of HAP3 genes leading to the origin of the seed-developmental regulatory gene, LEAFY COTYLEDON1 (LEC1), in nonseed plant genomes. Molecular biology and evolution 45 18453547
2008 In cultured oligodendrocytes the A/B-type hnRNP CBF-A accompanies MBP mRNA bound to mRNA trafficking sequences. Molecular biology of the cell 45 18480411
1994 Sequence of the HAP3 transcription factor of Kluyveromyces lactis predicts the presence of a novel 4-cysteine zinc-finger motif. Molecular & general genetics : MGG 45 7845362
2020 NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin. Nature metabolism 42 32694663
1992 Positive regulation of the LPD1 gene of Saccharomyces cerevisiae by the HAP2/HAP3/HAP4 activation system. Molecular & general genetics : MGG 38 1310523
1994 A mutant hook-associated protein (HAP3) facilitates torsionally induced transformations of the flagellar filament of Escherichia coli. Journal of molecular biology 36 8158647
2011 Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia. PloS one 34 22132193
2011 In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is mediated by A2RE/RTS elements. Molecular biology of the cell 33 21471000
2013 The transacting factor CBF-A/Hnrnpab binds to the A2RE/RTS element of protamine 2 mRNA and contributes to its translational regulation during mouse spermatogenesis. PLoS genetics 32 24146628
2000 CArG binding factor A (CBF-A) is involved in transcriptional regulation of the rat Ha-ras promoter. Nucleic acids research 32 11000268
1997 Telomeric and tetraplex DNA binding properties of qTBP42: a homologue of the CArG box binding protein CBF-A. Biochemical and biophysical research communications 32 9299414
2016 NF-YB Regulates Spermatogonial Stem Cell Self-Renewal and Proliferation in the Planarian Schmidtea mediterranea. PLoS genetics 23 27304889
2021 TOC1 clock protein phosphorylation controls complex formation with NF-YB/C to repress hypocotyl growth. The EMBO journal 21 34726281
1994 MBR1 and MBR3, two related yeast genes that can suppress the growth defect of hap2, hap3 and hap4 mutants. Molecular & general genetics : MGG 21 8208248
2000 CBF--a biophysical perspective. Seminars in cell & developmental biology 20 11105902
2021 NFYB potentiates STK33 activation to promote cisplatin resistance in diffuse large B-cell lymphoma. Leukemia research 15 34536775
2018 Genome-Wide Analysis of the NF-YB Gene Family in Gossypium hirsutum L. and Characterization of the Role of GhDNF-YB22 in Embryogenesis. International journal of molecular sciences 15 29415481
2015 E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program. PloS one 15 26039627
2019 Nuclear Factor Y (NF-Y) Modulates Encystation in Entamoeba via Stage-Specific Expression of the NF-YB and NF-YC Subunits. mBio 14 31213550
2010 Dysbindin regulates the transcriptional level of myristoylated alanine-rich protein kinase C substrate via the interaction with NF-YB in mice brain. PloS one 14 20098743
2019 Genome-wide analysis of poplar NF-YB gene family and identified PtNF-YB1 important in regulate flowering timing in transgenic plants. BMC plant biology 10 31185907
2022 Identification and Characterization of Abiotic Stress-Responsive NF-YB Family Genes in Medicago. International journal of molecular sciences 9 35805915
2021 NF-YB-Mediated Active Responses of Plant Growth under Salt and Temperature Stress in Eucalyptus grandis. Plants (Basel, Switzerland) 9 34072675
2024 Overexpression of an NF-YB gene family member, EaNF-YB2, enhances drought tolerance in sugarcane (Saccharum Spp. Hybrid). BMC plant biology 7 39722010
1994 Studies on the structure of the mouse CBF-A gene and properties of a truncated CBF-A isoform generated from an alternatively spliced RNA. Gene 7 7509302
2007 Exclusion of NFYB as candidate gene for congenital splay leg in piglets and radiation hybrid mapping of further five homologous porcine genes from human chromosome 12 (HSA12). Cytogenetic and genome research 6 17901702
2005 The kappa promoter penta-decamer binding protein CBF-A interacts specifically with nucleophosmin in the nucleus only. Molecular immunology 6 16360014
2023 NFYB increases chemosensitivity in glioblastoma by promoting HDAC5-mediated transcriptional inhibition of SHMT2. Journal of neuropathology and experimental neurology 5 37742129
2022 Over-expression of NFYB affects stromal cells reprogramming and predicts worse survival in gastric cancer patients. Aging 5 36152055
2021 Cdc25B is transcriptionally inhibited by IER5 through the NF-YB transcription factor in irradiation-treated HeLa cells. Toxicology research 5 34484679
2017 Chicken CCDC152 shares an NFYB-regulated bidirectional promoter with a growth hormone receptor antisense transcript and inhibits cells proliferation and migration. Oncotarget 5 29137403
2015 Identification and characterization of NF-YB family genes in tung tree. Molecular genetics and genomics : MGG 5 26037219
2024 Coptisine-mediated downregulation of E2F7 induces G2/M phase arrest in hepatocellular carcinoma cells through inhibition of E2F4/NFYA/NFYB transcription factors. Chemico-biological interactions 4 38795876
2022 Long Non-coding RNA H19 Recruits NFYB to Activate MBTD1 and Regulate Doxorubicin Resistance in Lymphoma Cells. Molecular biotechnology 4 36434485
1996 Identification of the transcription factors NF-YA and NF-YB as factors A and B that bound to the promoter of the major histocompatibility complex class II gene I-A beta. The Biochemical journal 4 8760361
2023 Transcription factors NF-YB involved in embryogenesis and hormones responses in Dimocarpus Longan Lour. Frontiers in plant science 3 37841620
2020 Attentional set shifting in HAP3, LAP3, and cHAP mice is unaffected by either genetic differences in alcohol preference or an alcohol drinking history. Experimental and clinical psychopharmacology 2 32150428
2004 Temperature may influence and regulate NF-YB expression in toad oocyte. Biochemical and biophysical research communications 2 14697263
2025 Enhancing HAP3 mediated xylose metabolism and acetic acid metabolism promotes lipid production from lignocellulosic hydrolysate fermented by Candida glycerinogenes. Biotechnology letters 1 40762860
2023 Comprehensive Analysis of the NF-YB Gene Family and Expression under Abiotic Stress and Hormone Treatment in Larix kaempferi. International journal of molecular sciences 1 37240255
2026 NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 0 42160015
2025 NF-YB-driven expression of long non-coding RNA linc01811 inhibiting glioma tumorigenesis by regulating miR-4635/NF-YB axis: A positive feedback loop. Biochemical and biophysical research communications 0 40505546

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