Affinage

NFYB

Nuclear transcription factor Y subunit beta · UniProt P25208

Length
207 aa
Mass
22.8 kDa
Annotated
2026-04-29
66 papers in source corpus 22 papers cited in narrative 22 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NFYB is the histone fold domain-containing subunit of the heterotrimeric NF-Y (CBF) transcription factor, a sequence-specific activator of CCAAT-box promoters that functions broadly in gene regulation, cell cycle control, drug resistance, and mitochondrial metabolism. NFYB heterodimerizes with NF-YC through reciprocal histone fold motifs structurally homologous to H2A/H2B, generating a platform that recruits NF-YA to complete the DNA-binding trimer (PMID:7878029, PMID:12401788). Beyond CCAAT-dependent transcription, NFYB contacts TBP/TFIID to couple promoter-bound NF-Y to the basal machinery (PMID:9153318), and directly transactivates genes including E2F1, STK33, HDAC5, and MBTD1, linking NF-Y to chemoresistance and cell cycle checkpoint pathways (PMID:29203250, PMID:34536775, PMID:37742129). In C. elegans, NFYB-1 represses lysosomal prosaposin to coordinate a lysosome-to-mitochondria lipid-signaling axis that controls cardiolipin levels, mitochondrial function, and organismal longevity (PMID:32694663).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1987 High

    Establishing that CCAAT-box binding requires the cooperative, interdependent action of two protein subunits (HAP2 and HAP3, the NF-YA and NF-YB orthologs) resolved the composition question for the CCAAT-binding factor.

    Evidence Gel shift and methylation interference with tagged yeast HAP2/HAP3 on CYC1 UAS2

    PMID:2826015

    Open questions at the time
    • Whether HAP2/HAP3 form a pre-assembled complex before DNA engagement was untested
    • Mammalian orthologs not yet identified
  2. 1988 High

    Demonstrating that HAP2 and HAP3 form a stable heteromeric complex in the absence of DNA established that subunit assembly precedes DNA binding, distinguishing this factor from cooperative DNA-nucleated assemblies.

    Evidence Affinity co-purification of LexA-HAP2/HAP3-β-gal fusions through four chromatographic steps

    PMID:2832951

    Open questions at the time
    • Third subunit (HAP4/NF-YA) not yet incorporated
    • Structural basis of the interaction unknown
  3. 1989 High

    Identifying HAP4 as a third subunit required for DNA binding and as the principal activation domain carrier defined the heterotrimeric architecture and division of labor within the complex.

    Evidence Genetic epistasis, in vitro reconstitution, and GAL4 activation-domain swap in yeast

    PMID:2676721

    Open questions at the time
    • Mammalian trimer not yet reconstituted
    • Whether the trimeric model applies across eukaryotes was unresolved
  4. 1990 High

    Cloning mammalian CBF-A (NF-YB) and revealing a 90-amino-acid domain conserved with yeast HAP3 established deep evolutionary conservation and enabled biochemical study in vertebrate systems.

    Evidence DNA affinity chromatography, cDNA cloning, and sequence alignment

    PMID:2266139

    Open questions at the time
    • Mammalian NF-YC not yet cloned
    • No reconstituted mammalian trimer
  5. 1995 High

    Reconstituting the mammalian NF-Y trimer from recombinant subunits and demonstrating that NF-YA associates only with the preformed NF-YB/NF-YC dimer defined the obligate assembly order of the complex.

    Evidence Recombinant protein reconstitution, EMSA, co-IP, and cross-linking with rat subunits

    PMID:7878029

    Open questions at the time
    • Structural basis of the NF-YB/NF-YC dimer unknown
    • NF-YA-binding surface on the dimer not mapped
  6. 1996 High

    Mapping the histone fold motif as the NF-YB/NF-YC dimerization interface and showing the dimer creates a tridentate surface for NF-YA identified the molecular logic of trimer assembly.

    Evidence Cross-linking, co-IP, yeast two-hybrid, and mutational analysis

    PMID:8754798

    Open questions at the time
    • No atomic-resolution structure
    • How the histone fold contacts DNA remained speculative
  7. 1997 High

    Showing that NF-YB and NF-YC physically interact with TBP/TFIID via short sequences flanking the histone fold domain linked the CCAAT-bound complex to the basal transcription machinery, explaining how NF-Y activates transcription.

    Evidence TFIID immunopurification, sedimentation, mutagenesis of TBP basic residues

    PMID:9153318

    Open questions at the time
    • Whether the NF-Y–TBP interaction is required in vivo at endogenous promoters was not tested
    • Contribution relative to other coactivators unknown
  8. 2002 High

    Solving the crystal structure of the NF-YB/NF-YC core confirmed an H2A/H2B-like histone fold dimer and revealed that the αC helix of NF-YC serves as an interaction platform for regulatory proteins (MYC, p53), providing the first structural framework for NF-Y regulation.

    Evidence X-ray crystallography with structural modeling of DNA-bound complex

    PMID:12401788

    Open questions at the time
    • Full trimer–DNA co-crystal not obtained
    • Regulatory protein complexes not structurally resolved
  9. 2010 Medium

    Identifying Dysbindin as a physical partner that co-occupies CCAAT elements with NF-YB to repress MARCKS transcription in mouse brain expanded NF-YB function into neuronal gene regulation and showed the trimer can act as a repressor in specific contexts.

    Evidence Yeast two-hybrid, co-IP, ChIP, and reporter assay in mouse brain

    PMID:20098743

    Open questions at the time
    • Single-lab study
    • Whether repression is direct or requires additional co-repressors is unclear
    • In vivo relevance in brain physiology not tested
  10. 2011 Medium

    Demonstrating that IER5 displaces co-activator p300 from the Cdc25B promoter through NF-YB, causing G2/M arrest, established NF-YB as a cell cycle checkpoint effector through cofactor exchange at CCAAT sites.

    Evidence ChIP, reporter assay, overexpression with flow cytometry in AML cells

    PMID:22132193 PMID:34484679

    Open questions at the time
    • Mechanism by which IER5 displaces p300 is not fully resolved
    • Generality beyond Cdc25B promoter unknown
  11. 2017 Medium

    Establishing the NFYB→E2F1→CHK1 transcriptional axis in oxaliplatin-resistant colorectal cancer positioned NF-YB as a direct upstream driver of chemoresistance through checkpoint kinase signaling.

    Evidence Knockdown/overexpression cascade, transcriptome profiling, in vivo xenograft assays

    PMID:29203250

    Open questions at the time
    • Direct NFYB binding to E2F1 promoter CCAAT box not demonstrated by ChIP in this study
    • Whether NFYB acts as part of the trimer or independently was not distinguished
  12. 2020 High

    Showing that C. elegans NFYB-1 represses lysosomal prosaposin to maintain cardiolipin levels and mitochondrial function revealed a conserved transcription factor operating in a lysosome-to-mitochondria lipid-signaling axis that controls longevity.

    Evidence RNAi screen, transcriptomics + metabolomics, genetic epistasis with prosaposin, cardiolipin supplementation rescue

    PMID:32694663

    Open questions at the time
    • Whether the prosaposin-cardiolipin axis is conserved in mammals is unknown
    • Direct promoter binding at prosaposin locus not shown by ChIP
  13. 2022 Medium

    Multiple studies showed NFYB directly transactivates diverse target promoters (STK33, MBTD1, HDAC5) to drive chemoresistance in lymphoma and glioblastoma, broadening the cancer-relevant transcriptional program of NF-YB beyond E2F1.

    Evidence ChIP-qPCR, luciferase reporters, knockdown/overexpression with drug sensitivity assays across multiple cancer types

    PMID:34536775 PMID:36434485 PMID:37742129

    Open questions at the time
    • Each axis characterized in single-lab studies in distinct cancer types
    • Whether these targets are NF-Y trimer-dependent versus NFYB-autonomous is not addressed
    • In vivo validation limited
  14. 2024 Medium

    Identifying NF-YA/NF-YB cooperation with E2F4 at the E2F7 promoter linked NF-Y to G2/M control in hepatocellular carcinoma and expanded the repertoire of E2F-family genes regulated by NF-Y.

    Evidence Promoter fragmentation, ChIP, RNA-seq, cell cycle assays in HCC cells

    PMID:38795876

    Open questions at the time
    • Single-lab study
    • Functional contribution of NF-YB versus NF-YA at this promoter not dissected

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unknown how NF-YB discriminates between activating and repressing roles at different promoters, whether NFYB can function outside the canonical NF-Y trimer in mammalian cells, and whether the lysosome-to-mitochondria lipid axis controlled by NFYB is conserved in vertebrates.
  • No full trimer–DNA co-crystal structure at atomic resolution
  • Genome-wide ChIP-seq of NFYB alone (versus trimer) not reported in the timeline
  • Mammalian in vivo knockout phenotype not characterized in the timeline

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 8 GO:0003677 DNA binding 4 GO:0042393 histone binding 1
Localization
GO:0005634 nucleus 8
Pathway
R-HSA-74160 Gene expression (Transcription) 12 R-HSA-1640170 Cell Cycle 3 R-HSA-5357801 Programmed Cell Death 2
Partners
DTNBP1EP300IER5NFYANFYCTBP
Complex memberships
NF-Y (CBF) heterotrimer

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1987 HAP2 and HAP3 (yeast orthologs of NF-YB/NF-YC) bind interdependently to the CCAAT-containing UAS2 element of CYC1 and form a single protein-DNA complex; binding of either factor is abolished when the other is absent. Gel mobility shift assay, methylation interference footprinting, beta-galactosidase fusion tagging Cell High 2826015
1988 HAP2 and HAP3 (yeast orthologs) form a stable heteromeric complex in the absence of DNA, co-purifying through four chromatographic steps, establishing that complex assembly precedes DNA binding. Affinity co-purification (LexA-HAP2 / HAP3-beta-galactosidase fusions), multi-step chromatography Science High 2832951
1989 HAP4 (yeast NF-YA-like activator) is a third subunit required for DNA binding by the HAP2/HAP3 heteromer at UAS2; HAP4 provides the principal transcriptional activation domain (acidic region replaceable by GAL4 activation domain). Genetic analysis, in vitro DNA binding assay, deletion mutagenesis, GAL4 activation domain swap Genes & development High 2676721
1990 Mammalian CBF-A (NF-YB) shares a conserved 90-amino-acid domain with yeast HAP3, establishing evolutionary conservation of the CCAAT-binding subunit. Protein purification by DNA affinity chromatography, cDNA cloning, sequence alignment, in vitro transcription/translation The Journal of biological chemistry High 2266139
1993 The DNA-binding domain of HAP2 (21 residues with critical histidines and arginines) and a 7-residue region of HAP3 (NF-YB ortholog) form a hybrid CCAAT-binding domain; mutations in HAP3 suppress DNA-binding mutations in HAP2, indicating direct inter-subunit contacts at the DNA interface. Site-directed mutagenesis, genetic suppressor analysis, in vitro DNA binding assay The EMBO journal High 8223474
1995 Recombinant rat CBF-C (NF-YC) is required together with CBF-A (NF-YB) and CBF-B (NF-YA) to form a CBF-DNA complex; CBF-A and CBF-C interact directly to form a heterodimer, and CBF-B associates only with the CBF-A/CBF-C complex, not with either subunit alone. Recombinant protein reconstitution, EMSA, co-immunoprecipitation, cross-linking Proceedings of the National Academy of Sciences of the United States of America High 7878029
1996 The histone fold motif of CBF-C (NF-YC) mediates interaction with CBF-A (NF-YB); the CBF-A/CBF-C heterodimer generates a tridentate interaction surface for CBF-B (NF-YA), defining the assembly order of the heterotrimeric NF-Y complex. Cross-linking, co-immunoprecipitation, yeast two-hybrid, mutational analysis, in vitro binding assays Molecular and cellular biology High 8754798
1996 NF-YA and NF-YB together (but not separately) bind the CCAAT Y-box of MHC class II gene I-Aβ promoter; antisense constructs against NF-YA or NF-YB each reduce reporter gene expression from the I-Aβ promoter. EMSA, supershift assay, antisense knockdown with reporter assay The Biochemical journal Medium 8760361
1997 NF-YB and NF-YC interact with TBP in solution and associate with TFIID; short conserved stretches adjacent to their histone fold motifs are necessary for TBP binding; TBP basic-residue mutants defective in NC2 binding also fail to bind NF-YB and NF-YC. Immunopurification of holo-TFIID, sedimentation velocity centrifugation, in vitro interaction assays, mutagenesis Nucleic acids research High 9153318
2002 Crystal structure of the NF-YC/NF-YB subcomplex reveals that the core domains interact via histone fold motifs closely related to H2A/H2B; the αC helix of NF-YC is essential for NF-Y trimerization and serves as a binding surface for regulatory proteins such as MYC and p53. X-ray crystallography, structural modeling of NF-YB/NF-YC/DNA and full NF-Y/CCAAT complex The Journal of biological chemistry High 12401788
2002 MADS-box protein OsMADS18 forms a ternary complex with rice NF-YB1 (and mouse NF-YB as NF-YB/NF-YC dimer) through MADS and I regions; NF-YB's histone fold motif mediates this interaction; a D99S mutation in the HFM α2-helix of OsNF-YB1 restores NF-YA interaction but not DNA binding, separating these functions. Yeast two-hybrid, co-immunoprecipitation in vivo and in vitro, site-directed mutagenesis The Journal of biological chemistry High 11971906
2010 Dysbindin physically interacts with NF-YB in mouse brain; the Dysbindin-NF-YB complex binds the MARCKS promoter via NF-YB's CCAAT-binding activity and represses MARCKS transcription; knockdown of either protein increases MARCKS expression. Yeast two-hybrid, co-immunoprecipitation, chromatin immunoprecipitation, DNA chip/reporter assay PloS one Medium 20098743
2011 IER5 binds the Cdc25B promoter and represses Cdc25B transcription through NF-YB and the co-activator p300 in AML cells; IER5 overexpression causes G2/M arrest via reduction of Cdc25B expression dependent on NF-YB and p300 displacement. ChIP, reporter assay, knockdown/overexpression with flow cytometry PloS one Medium 22132193
2015 NFYB is a direct transcriptional target of E2F1; NFYB knockdown enhances E2F1-induced apoptosis, indicating NFYB mediates a pro-survival joint transcriptional program downstream of E2F1. Genome-wide expression analysis, NFYB knockdown, apoptosis assay PloS one Medium 26039627
2017 NFYB transactivates the E2F1 gene promoter in oxaliplatin-resistant colorectal cancer cells; the NFYB→E2F1→CHK1 axis suppresses oxaliplatin-induced apoptosis and maintains tumorigenicity in vitro and in vivo. Knockdown/overexpression, transcriptome profiling, in vitro and in vivo phenotype assays Cancer letters Medium 29203250
2020 C. elegans NFYB-1 (NF-Y beta subunit) regulates mitochondrial gene expression, oxygen consumption, mitochondrial morphology, and cardiolipin levels; NFYB-1 represses lysosomal prosaposin, and limiting prosaposin restores cardiolipin production, mitochondrial function, and longevity in nfyb-1 mutants. RNAi screens, multi-omics (transcriptomics + metabolomics), genetic epistasis (prosaposin limitation rescues nfyb-1), cardiolipin supplementation rescue Nature metabolism High 32694663
2021 NFYB binds the STK33 promoter and activates STK33 transcription; STK33 promotes cisplatin resistance in DLBCL by activating the Hedgehog signaling pathway downstream of NFYB. ChIP, luciferase reporter, knockdown/overexpression with drug sensitivity assays Leukemia research Medium 34536775
2021 IER5 upregulation after irradiation induces release of co-activator p300 from the Cdc25B promoter through interaction with NF-YB, leading to transcriptional repression of Cdc25B via the NF-YB binding site; both Sp1/Sp3 and NF-YB binding sites are required for irradiation-mediated Cdc25B regulation. ChIP assay, dual-luciferase reporter, site-directed mutagenesis of promoter elements Toxicology research Medium 34484679
2022 NFYB binds the MBTD1 promoter to activate MBTD1 transcription; lncRNA H19 recruits NFYB to increase MBTD1 expression without altering NFYB levels, promoting doxorubicin resistance in lymphoma cells. Luciferase reporter assay, ChIP-qPCR, H19 knockdown/overexpression with drug resistance readout Molecular biotechnology Medium 36434485
2023 NFYB activates HDAC5 transcription by binding the HDAC5 promoter; HDAC5 in turn inhibits SHMT2 expression, and the NFYB→HDAC5→SHMT2 axis reduces glycolysis and temozolomide resistance in GBM cells. ChIP, dual-luciferase reporter, overexpression/knockdown with metabolic and cell viability assays Journal of neuropathology and experimental neurology Medium 37742129
2024 E2F4, NF-YA, and NF-YB act together as transcription factors at the E2F7 promoter; coptisine inhibits HCC by downregulating these transcription factors, reducing E2F7 expression and inducing G2/M arrest. Promoter fragmentation experiments, ChIP, RNA-seq, overexpression/inhibition with cell cycle assays Chemico-biological interactions Medium 38795876
2025 NFYB (as part of the NF-Y pioneer transcription factor complex) cooperates with the menin-MLL1 chromatin complex to regulate oncogenic gene transcription in HCC; NFYB knockout combined with menin inhibition causes significantly increased HCC cell death, placing NF-Y as a compensatory transcriptional activator at sites of menin-MLL1 dissociation. CRISPR/Cas9 epigenome-focused screens, chromatin accessibility (ATAC-seq), ChIP-seq, genetic epistasis (NFYB KO + menin inhibitor) bioRxivpreprint Medium bio_10.1101_2025.04.05.647381

Source papers

Stage 0 corpus · 66 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1989 Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer. Genes & development 349 2676721
1995 Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proceedings of the National Academy of Sciences of the United States of America 253 7878029
2002 The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. The Journal of biological chemistry 233 12401788
1987 Yeast HAP2 and HAP3 activators both bind to the CYC1 upstream activation site, UAS2, in an interdependent manner. Cell 211 2826015
2009 Arabidopsis NF-YB subunits LEC1 and LEC1-LIKE activate transcription by interacting with seed-specific ABRE-binding factors. The Plant journal : for cell and molecular biology 169 19207209
1993 Mutations in yeast HAP2/HAP3 define a hybrid CCAAT box binding domain. The EMBO journal 136 8223474
1996 Determination of functional domains in the C subunit of the CCAAT-binding factor (CBF) necessary for formation of a CBF-DNA complex: CBF-B interacts simultaneously with both the CBF-A and CBF-C subunits to form a heterotrimeric CBF molecule. Molecular and cellular biology 130 8754798
2017 CONSTANS Imparts DNA Sequence Specificity to the Histone Fold NF-YB/NF-YC Dimer. The Plant cell 124 28526714
1988 Mutational analysis of upstream activation sequence 2 of the CYC1 gene of Saccharomyces cerevisiae: a HAP2-HAP3-responsive site. Molecular and cellular biology 119 2832731
1988 Yeast HAP2 and HAP3: transcriptional activators in a heteromeric complex. Science (New York, N.Y.) 115 2832951
1988 The HAP3 regulatory locus of Saccharomyces cerevisiae encodes divergent overlapping transcripts. Molecular and cellular biology 108 2832732
1997 CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues. Nucleic acids research 103 9153318
2002 Ternary complex formation between MADS-box transcription factors and the histone fold protein NF-YB. The Journal of biological chemistry 87 11971906
1990 Purification and molecular cloning of the "A" chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor. The Journal of biological chemistry 83 2266139
2020 Structural Insight into DNA Recognition by CCT/NF-YB/YC Complexes in Plant Photoperiodic Flowering. The Plant cell 67 32843433
2007 The tetraplex (CGG)n destabilizing proteins hnRNP A2 and CBF-A enhance the in vivo translation of fragile X premutation mRNA. Nucleic acids research 65 17716999
2017 NFYB-induced high expression of E2F1 contributes to oxaliplatin resistance in colorectal cancer via the enhancement of CHK1 signaling. Cancer letters 60 29203250
2000 Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF - a model for overcoming inhibition of proliferation by CBF oncoproteins. Oncogene 51 10851069
2024 Unraveling the intricacies of glioblastoma progression and recurrence: insights into the role of NFYB and oxidative phosphorylation at the single-cell level. Frontiers in immunology 48 38510250
2008 Duplication and functional diversification of HAP3 genes leading to the origin of the seed-developmental regulatory gene, LEAFY COTYLEDON1 (LEC1), in nonseed plant genomes. Molecular biology and evolution 45 18453547
2008 In cultured oligodendrocytes the A/B-type hnRNP CBF-A accompanies MBP mRNA bound to mRNA trafficking sequences. Molecular biology of the cell 45 18480411
1994 Sequence of the HAP3 transcription factor of Kluyveromyces lactis predicts the presence of a novel 4-cysteine zinc-finger motif. Molecular & general genetics : MGG 45 7845362
2020 NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin. Nature metabolism 39 32694663
1992 Positive regulation of the LPD1 gene of Saccharomyces cerevisiae by the HAP2/HAP3/HAP4 activation system. Molecular & general genetics : MGG 38 1310523
1994 A mutant hook-associated protein (HAP3) facilitates torsionally induced transformations of the flagellar filament of Escherichia coli. Journal of molecular biology 36 8158647
2011 Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia. PloS one 34 22132193
2011 In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is mediated by A2RE/RTS elements. Molecular biology of the cell 33 21471000
2013 The transacting factor CBF-A/Hnrnpab binds to the A2RE/RTS element of protamine 2 mRNA and contributes to its translational regulation during mouse spermatogenesis. PLoS genetics 32 24146628
2000 CArG binding factor A (CBF-A) is involved in transcriptional regulation of the rat Ha-ras promoter. Nucleic acids research 32 11000268
1997 Telomeric and tetraplex DNA binding properties of qTBP42: a homologue of the CArG box binding protein CBF-A. Biochemical and biophysical research communications 32 9299414
2016 NF-YB Regulates Spermatogonial Stem Cell Self-Renewal and Proliferation in the Planarian Schmidtea mediterranea. PLoS genetics 23 27304889
2021 TOC1 clock protein phosphorylation controls complex formation with NF-YB/C to repress hypocotyl growth. The EMBO journal 21 34726281
1994 MBR1 and MBR3, two related yeast genes that can suppress the growth defect of hap2, hap3 and hap4 mutants. Molecular & general genetics : MGG 21 8208248
2000 CBF--a biophysical perspective. Seminars in cell & developmental biology 20 11105902
2021 NFYB potentiates STK33 activation to promote cisplatin resistance in diffuse large B-cell lymphoma. Leukemia research 15 34536775
2015 E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program. PloS one 15 26039627
2019 Nuclear Factor Y (NF-Y) Modulates Encystation in Entamoeba via Stage-Specific Expression of the NF-YB and NF-YC Subunits. mBio 14 31213550
2018 Genome-Wide Analysis of the NF-YB Gene Family in Gossypium hirsutum L. and Characterization of the Role of GhDNF-YB22 in Embryogenesis. International journal of molecular sciences 14 29415481
2010 Dysbindin regulates the transcriptional level of myristoylated alanine-rich protein kinase C substrate via the interaction with NF-YB in mice brain. PloS one 14 20098743
2024 Molecular condensation of the CO/NF-YB/NF-YC/FT complex gates floral transition in Arabidopsis. The EMBO journal 13 39567828
2023 NF-YB family transcription factors in Arabidopsis: Structure, phylogeny, and expression analysis in biotic and abiotic stresses. Frontiers in microbiology 12 36733773
2019 Genome-wide analysis of poplar NF-YB gene family and identified PtNF-YB1 important in regulate flowering timing in transgenic plants. BMC plant biology 10 31185907
2022 Identification and Characterization of Abiotic Stress-Responsive NF-YB Family Genes in Medicago. International journal of molecular sciences 9 35805915
2021 NF-YB-Mediated Active Responses of Plant Growth under Salt and Temperature Stress in Eucalyptus grandis. Plants (Basel, Switzerland) 8 34072675
1994 Studies on the structure of the mouse CBF-A gene and properties of a truncated CBF-A isoform generated from an alternatively spliced RNA. Gene 7 7509302
2024 Overexpression of an NF-YB gene family member, EaNF-YB2, enhances drought tolerance in sugarcane (Saccharum Spp. Hybrid). BMC plant biology 6 39722010
2007 Exclusion of NFYB as candidate gene for congenital splay leg in piglets and radiation hybrid mapping of further five homologous porcine genes from human chromosome 12 (HSA12). Cytogenetic and genome research 6 17901702
2005 The kappa promoter penta-decamer binding protein CBF-A interacts specifically with nucleophosmin in the nucleus only. Molecular immunology 6 16360014
2023 NFYB increases chemosensitivity in glioblastoma by promoting HDAC5-mediated transcriptional inhibition of SHMT2. Journal of neuropathology and experimental neurology 5 37742129
2022 Over-expression of NFYB affects stromal cells reprogramming and predicts worse survival in gastric cancer patients. Aging 5 36152055
2021 Cdc25B is transcriptionally inhibited by IER5 through the NF-YB transcription factor in irradiation-treated HeLa cells. Toxicology research 5 34484679
2017 Chicken CCDC152 shares an NFYB-regulated bidirectional promoter with a growth hormone receptor antisense transcript and inhibits cells proliferation and migration. Oncotarget 5 29137403
2015 Identification and characterization of NF-YB family genes in tung tree. Molecular genetics and genomics : MGG 5 26037219
2024 Coptisine-mediated downregulation of E2F7 induces G2/M phase arrest in hepatocellular carcinoma cells through inhibition of E2F4/NFYA/NFYB transcription factors. Chemico-biological interactions 4 38795876
2023 Analysis of gene duplication within the Arabidopsis NUCLEAR FACTOR Y, subunit B (NF-YB) protein family reveals domains under both purifying and diversifying selection. PloS one 4 37531316
2022 Long Non-coding RNA H19 Recruits NFYB to Activate MBTD1 and Regulate Doxorubicin Resistance in Lymphoma Cells. Molecular biotechnology 4 36434485
2021 Modulation of NF-YB genes in Ricinus communis L. in response to different temperatures and developmental stages and functional characterization of RcNF-YB8 as an important regulator of flowering time in Arabidopsis thaliana. Plant physiology and biochemistry : PPB 4 34087742
1996 Identification of the transcription factors NF-YA and NF-YB as factors A and B that bound to the promoter of the major histocompatibility complex class II gene I-A beta. The Biochemical journal 4 8760361
2023 Transcription factors NF-YB involved in embryogenesis and hormones responses in Dimocarpus Longan Lour. Frontiers in plant science 3 37841620
2020 Attentional set shifting in HAP3, LAP3, and cHAP mice is unaffected by either genetic differences in alcohol preference or an alcohol drinking history. Experimental and clinical psychopharmacology 2 32150428
2004 Temperature may influence and regulate NF-YB expression in toad oocyte. Biochemical and biophysical research communications 2 14697263
2025 Enhancing HAP3 mediated xylose metabolism and acetic acid metabolism promotes lipid production from lignocellulosic hydrolysate fermented by Candida glycerinogenes. Biotechnology letters 1 40762860
2024 A CAM-Related NF-YB Transcription Factor Enhances Multiple Abiotic Stress Tolerance in Arabidopsis. International journal of molecular sciences 1 39000218
2023 Comprehensive Analysis of the NF-YB Gene Family and Expression under Abiotic Stress and Hormone Treatment in Larix kaempferi. International journal of molecular sciences 1 37240255
2018 Overexpression of RcLEC1-B, a HAP3 transcription factor of PLB from Rosa canina, increases the level of endogenous gibberellin and alters the development of cuticle and floral organs in Arabidopsis. Gene 1 30529094
2025 NF-YB-driven expression of long non-coding RNA linc01811 inhibiting glioma tumorigenesis by regulating miR-4635/NF-YB axis: A positive feedback loop. Biochemical and biophysical research communications 0 40505546