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Showing NDRG1 — NDR1 is a alias.

NDRG1

Protein NDRG1 · UniProt Q92597

Length
394 aa
Mass
42.8 kDa
Annotated
2026-06-10
100 papers in source corpus 54 papers cited in narrative 54 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NDRG1 is a stress- and metal-responsive signaling scaffold that integrates transcriptional and post-translational inputs to suppress oncogenic signaling, regulate metabolism, and maintain cellular homeostasis (PMID:15377670, PMID:11330481, PMID:28371345). It is transcriptionally induced through multiple stress-sensing axes: p53 binds the proximal promoter to drive expression upon DNA damage and growth arrest (PMID:15377670, PMID:17442733), HIF-1 mediates hypoxic induction via a defined promoter element (PMID:15341671, PMID:23526365), and Ni(II) acts through a Ca2+/PI3K-Akt-HIF route (PMID:9605764, PMID:14729612), while VHL, ERα, androgen, and KDM1A repress it (PMID:12767066, PMID:16707596, PMID:34512147, PMID:36908010). Structurally, NDRG1 adopts an α/β hydrolase fold with flexible N- and C-terminal regions that bind lipid vesicles, and a C-terminal 10-residue repeat domain coordinates Ni(II)/Cu(II) through histidine imidazole nitrogens (PMID:11330481, PMID:15149799, PMID:33305529). Its activity is gated by C-terminal Ser/Thr phosphorylation: SGK1 (and GSK3β) phosphorylation at Ser330/Thr346 is required to attenuate NF-κB signaling by lowering IKKβ and blocking p65/p50 nuclear translocation (PMID:19491262, PMID:20416281, PMID:31723002), and mTORC2-dependent Ser336 phosphorylation directs NDRG1 to mitochondria where it cooperates with CDC42 to drive fission during fasting (PMID:37386153). As a metastasis suppressor it acts through an ATF3/NF-κB/KAI1 cascade and restrains cytoskeletal remodeling by preserving RhoGDIα–CDC42 binding to limit CDC42/PAK1/Cofilin-driven invasion (PMID:21454613, PMID:33994856, PMID:28371345). NDRG1 also dampens receptor tyrosine kinase signaling by inhibiting EGFR/HER2/HER3 dimerization and promoting EGFR degradation (PMID:28615452, PMID:34385595), stabilizes the AR–HSP90 complex to suppress androgen receptor transactivation (PMID:34785213), binds PLCγ1 to support VEGF-A-induced angiogenesis (PMID:32144393), and controls lipid handling through endosomal LDLR trafficking, lipid-droplet limitation, and apolipoprotein A-I/A-II association (PMID:23813961, PMID:15922294, PMID:29898756). Additional roles span DNA-repair-linked drug resistance via MGMT stabilization and NSUN6/ALYREF-controlled mRNA stability promoting homologous recombination (PMID:24367102, PMID:38970106), centrosome homeostasis through γ-tubulin association (PMID:21708134, PMID:26324937), immune regulation as an Egr2-induced T-cell anergy factor and a determinant of mast-cell degranulation (PMID:26507712, PMID:17513753), and ER-stress and autophagy modulation (PMID:30981813, PMID:32335136, PMID:38228036). Apolipoprotein binding links NDRG1 to Schwann-cell lipid trafficking, consistent with the HMSNL-associated R148X founder mutation (PMID:15922294).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1998 Medium

    Established the upstream signal that drives NDRG1 induction, showing it is a metal- and Ca2+-responsive gene rather than constitutively expressed.

    Evidence mRNA differential display with Ca2+ ionophores and chelators across human/rodent cells

    PMID:9605764

    Open questions at the time
    • Did not connect Ca2+ signal to a specific transcription factor
    • Functional consequence of induction not addressed
  2. 2004 High

    Placed NDRG1 transcription under defined stress transcription factors, linking it to the p53 DNA-damage program and the HIF-1/oxygen-sensing pathway.

    Evidence Promoter-reporter, RNAi, inducible expression, HIF-1 knockout cells, and dominant-negative PI3K/Akt in cancer cell lines

    PMID:12767066 PMID:14729612 PMID:15341671 PMID:15377670

    Open questions at the time
    • How p53 vs HIF inputs are integrated at a single promoter is unresolved
    • VHL→Sp1 repression mechanism not linked to protein function
  3. 2001 High

    Defined the structural basis of NDRG1 metal binding, showing histidine imidazole coordination of Ni(II)/Cu(II) in the C-terminal repeats.

    Evidence pH-metric and spectroscopic (UV-VIS, EPR, CD, NMR) analysis of synthetic repeat peptides

    PMID:11330481 PMID:15149799

    Open questions at the time
    • Physiological role of metal binding by full-length protein unclear
    • Peptide studies do not capture intact-protein context
  4. 2009 High

    Identified the core anti-inflammatory/anti-metastatic mechanism: NDRG1 suppresses NF-κB by reducing IKKβ and requires dual C-terminal phosphorylation by SGK1.

    Evidence Overexpression with IKKβ rescue, site-directed Ser330/Thr346 mutagenesis, reporter/ChIP assays and xenografts

    PMID:19491262 PMID:20416281

    Open questions at the time
    • Direct mechanism by which NDRG1 lowers IKKβ expression not defined
    • Whether phosphorylation creates a binding surface unknown
  5. 2011 High

    Linked NDRG1 to mitosis and genome stability through phosphorylation-dependent centrosome localization and γ-tubulin association.

    Evidence Cell-cycle synchronization with γ-tubulin co-localization and Co-IP in isogenic TP53 cells

    PMID:21708134 PMID:26324937

    Open questions at the time
    • Molecular function of NDRG1 at the centrosome undefined
    • Direct vs indirect γ-tubulin interaction not resolved
  6. 2011 High

    Established the transcriptional output of NDRG1-mediated metastasis suppression via the ATF3/NF-κB/KAI1 axis.

    Evidence ChIP of ATF3 at KAI1 promoter, reporter assays, KAI1 knockdown epistasis, in vivo metastasis models

    PMID:21454613

    Open questions at the time
    • How NDRG1 suppresses ATF3 mechanistically is unclear
  7. 2017 High

    Defined NDRG1 control of cytoskeletal dynamics, showing it preserves RhoGDIα–CDC42 binding to restrain invasive actin remodeling.

    Evidence CDC42 pull-down, RhoGDIα-CDC42 Co-IP, live-cell actin imaging and in vivo metastasis assays

    PMID:28371345 PMID:33994856

    Open questions at the time
    • Direct binding partner of NDRG1 within the RhoGDIα-CDC42 complex not identified
  8. 2017 High

    Extended NDRG1 to immune regulation as an Egr2-induced, proteasome-degraded T-cell anergy factor and a mast-cell degranulation determinant.

    Evidence Ndrg1 knockout mice, proteasome inhibition, anergy and FcεRI degranulation assays

    PMID:17513753 PMID:26507712

    Open questions at the time
    • Molecular targets of NDRG1 enforcing anergy unknown
    • Degranulation defect mechanism not defined
  9. 2013 High

    Connected NDRG1 to therapy resistance and lipid trafficking, stabilizing MGMT and regulating endosomal LDLR sorting.

    Evidence Reciprocal Co-IP (NDRG1-MGMT), IDOL co-depletion epistasis, LDLR ubiquitylation and uptake assays

    PMID:23813961 PMID:24367102

    Open questions at the time
    • How NDRG1 mechanistically promotes MVB formation unclear
    • Whether MGMT stabilization is direct not fully resolved
  10. 2020 High

    Established NDRG1 as an angiogenic signaling adaptor by direct PLCγ1 binding required for VEGF-A responses.

    Evidence NDRG1-PLCγ1 Co-IP, Ndrg1 knockout mice, corneal/aortic angiogenesis assays

    PMID:32144393

    Open questions at the time
    • Phosphosite-dependence of the PLCγ1 interaction not mapped
  11. 2021 High

    Defined NDRG1 suppression of androgen receptor signaling via AR–HSP90 stabilization and CAP-domain dependence.

    Evidence AR-HSP90 Co-IP, CAP-domain deletion mutants, AR reporter and PSA assays

    PMID:34785213

    Open questions at the time
    • Structural basis of CAP domain action on AR unknown
  12. 2021 High

    Provided the structural model of NDRG1, defining the α/β hydrolase fold and lipid-binding flexible termini.

    Evidence X-ray crystallography (PDB 6ZMM), SAXS, CD and lipid vesicle binding

    PMID:33305529

    Open questions at the time
    • Catalytic activity of the hydrolase fold, if any, not demonstrated
    • Aggregation with metals leaves physiological metal role unresolved
  13. 2023 High

    Revealed a metabolic membrane-remodeling function: mTORC2 phosphorylates NDRG1 at Ser336 to drive CDC42-dependent mitochondrial fission during fasting.

    Evidence Live imaging, S336A mutant, DRP1/Rictor/Cdc42 KO epistasis, proteomics and CDC42 Co-IP

    PMID:37386153

    Open questions at the time
    • How phospho-NDRG1 physically engages the fission machinery is not fully defined
  14. 2024 High

    Linked NDRG1 mRNA stability to DNA repair and immune evasion through NSUN6/ALYREF m5C methylation and ATG9A-dependent MHC-I control.

    Evidence m5C-seq with RIP and HR repair assays; autophagy inhibitor epistasis with MHC-I/T-cell readouts in vivo

    PMID:38228036 PMID:38970106

    Open questions at the time
    • Direct HR repair role of NDRG1 protein vs transcriptional consequence not separated
    • Mechanism of ATG9A pathway inhibition incomplete

Open questions

Synthesis pass · forward-looking unresolved questions
  • The biochemical activity of the conserved α/β hydrolase fold and the unifying mechanism by which a single scaffold coordinates NF-κB, RTK, cytoskeletal, metabolic and trafficking outputs remain undefined.
  • No catalytic substrate identified for the hydrolase fold
  • No structure of full-length phosphorylated NDRG1 with a partner
  • Whether the many reported interactions share a common binding determinant is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0098772 molecular function regulator activity 4 GO:0008289 lipid binding 3
Localization
GO:0005634 nucleus 2 GO:0005815 microtubule organizing center 2 GO:0005829 cytosol 2 GO:0005739 mitochondrion 1 GO:0005768 endosome 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-1430728 Metabolism 3 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 3 R-HSA-8953897 Cellular responses to stimuli 3 R-HSA-5653656 Vesicle-mediated transport 2
Partners
ARCDC42EGFRHSP90MGMTPCNAPLCG1TUBG1

Evidence

Reading pass · 54 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 Cap43/NDRG1 expression is specifically induced by Ni2+ compounds via elevation of free intracellular Ca2+; induction was attenuated by intracellular Ca2+ chelation and mimicked by calcium ionophores, establishing Ca2+ as the primary intracellular signal for nickel-mediated Cap43 induction. mRNA differential display, pharmacological manipulation (Ca2+ ionophores, BAPTA-AM chelator, okadaic acid), Northern blot in multiple human/rodent cell lines and rat organs Cancer research Medium 9605764
1997 TDD5/NDRG1 mRNA expression is differentially repressed by testosterone and dihydrotestosterone (DHT) at the mRNA level in androgen-responsive cells, with testosterone showing preferential repression over DHT. mRNA differential display PCR (DDPCR), Northern blot, in vivo animal DHT administration studies Proceedings of the National Academy of Sciences of the United States of America Medium 9144177
2004 NDRG1 is a p53-regulated gene induced by DNA damage in a p53-dependent manner; the NDRG1 promoter contains a p53 binding site conferring p53-dependent transcriptional activation. NDRG1 is necessary but not sufficient for p53-mediated caspase activation and apoptosis. Promoter-reporter assay, RNA interference (RNAi), inducible gene expression, caspase activation assays The Journal of biological chemistry High 15377670
2004 Hypoxic induction of NDRG1 is predominantly dependent on the HIF-1 transcription factor, but HIF-1-independent pathways also contribute during chronic hypoxia. Nickel compounds likely induce NDRG1 by interacting with the oxygen-sensing pathway. Hypoxia mimetics treatment, HIF-1 knockout cells, Western blot, in vitro expression assays BMC genetics Medium 15341671
2004 Nickel compounds induce HIF-1 transactivation and Cap43/NDRG1 protein expression through a PI3K/Akt-dependent and p70S6k-independent signaling pathway. Dominant-negative PI3K and Akt mutant overexpression, rapamycin inhibition, Western blot, HIF-1 transactivation assays Cancer research High 14729612
2001 Ni(II) and Cu(II) bind to the C-terminal 10-amino acid repeat domain of Cap43/NDRG1 (sequence TRSRSHTSEG) via the imidazole nitrogen of histidine residues, forming octahedral and square planar complexes. pH-metric and spectroscopic analyses (UV-VIS, EPR, CD, NMR) of synthetic peptide Journal of inorganic biochemistry High 11330481
2004 Ni(II) binds to two or three sites on the 20- and 30-amino acid C-terminal repeat fragments of Cap43/NDRG1 respectively, with each Ni(II) ion coordinated to the histidine imidazole of each 10-amino acid repeat unit. pH-metric titration, UV-visible spectroscopy, CD, NMR of synthetic peptide fragments Journal of inorganic biochemistry High 15149799
2003 VHL tumor suppressor specifically downregulates Cap43/NDRG1 expression through an Sp1 site in the promoter region (−286 to −62 bp) of the Cap43 gene in renal cancer cells. VHL transfection into VHL-negative cells, Cap43 promoter deletion/mutation reporter assays, Western blot, Northern blot International journal of cancer High 12767066
2013 NDRG1 binds and stabilizes MGMT (O6-methylguanine-DNA methyltransferase), conferring resistance to alkylating chemotherapy. NDRG1 is an mTORC2/SGK1 pathway target induced by hypoxia, irradiation, corticosteroids, and alkylating agents. Co-immunoprecipitation (NDRG1-MGMT interaction), NDRG1 knockdown/overexpression, mTORC2/SGK1 pathway analysis, patient tissue analysis Proceedings of the National Academy of Sciences of the United States of America High 24367102
2009 NDRG1/Cap43 suppresses NF-κB signaling by decreasing IKKβ expression, reducing IκBα phosphorylation, and blocking nuclear translocation of p65/p50, thereby attenuating expression of CXC chemokines (CXCL1, CXCL5, IL-8) and VEGF-A; exogenous IKKβ rescues these effects. Stable overexpression, IKKβ rescue transfection, NF-κB reporter assays, ChIP, immunoblot, xenograft mouse models Cancer research High 19491262
2010 Phosphorylation of NDRG1/Cap43 by SGK1 at both Ser330 and Thr346 (but not individually) in the C-terminal domain (aa 326–394) is required for suppression of NF-κB signaling and CXC chemokine (CXCL1, CXCL5) expression in pancreatic cancer cells. Deletion constructs, site-directed mutagenesis of Ser/Thr residues, stable expression, ELISA for chemokines, IκBα phosphorylation assays Biochemical and biophysical research communications High 20416281
2011 NDRG1 is phosphorylated by SGK1 and GSK3β in a cell-cycle-dependent manner; phosphorylated NDRG1 co-localizes with γ-tubulin at centromeres and at the cleavage furrow during cytokinesis, suggesting a role in mitosis. Cell cycle synchronization (aphidicolin, nocodazole), immunofluorescence co-localization with γ-tubulin, p53-proficient vs. deficient HCT116 cells, phospho-specific antibodies Biochemical and biophysical research communications Medium 21708134
2013 NDRG1 silencing in epithelial cells reduces LDL receptor (LDLR) abundance at the plasma membrane by causing LDLR accumulation in enlarged EEA1-positive endosomes with increased LDLR ubiquitylation; co-depletion of IDOL (E3 ligase) rescues LDLR at the plasma membrane, identifying NDRG1 as a regulator of multivesicular body formation and endosomal LDLR trafficking. siRNA silencing, confocal microscopy, LDLR ubiquitylation assays, co-depletion (NDRG1 + IDOL), LDL uptake assays, murine oligodendrocyte studies Journal of cell science High 23813961
2005 NDRG1 physically interacts with apolipoproteins A-I and A-II (confirmed by yeast two-hybrid and mammalian cell co-immunoprecipitation), suggesting a role in Schwann cell lipid/cholesterol trafficking; the HMSNL founder mutation R148X is associated with decreased HDL-C levels. Yeast two-hybrid screening, reciprocal co-immunoprecipitation in mammalian cells, biochemical lipid analysis Biochemical and biophysical research communications Medium 15922294
2011 NDRG1 promotes metastasis suppression through the ATF3/NF-κB/KAI1 transcriptional cascade: NDRG1 expression suppresses ATF3, which normally represses KAI1 through ATF3-NFκB co-repressor complex. Knockdown of KAI1 abrogates NDRG1-mediated metastasis suppression in vitro and in vivo. ChIP analysis of ATF3 binding to KAI1 promoter, stable NDRG1 overexpression/silencing, KAI1 promoter reporter assays, in vivo spontaneous metastasis animal model, immunohistochemistry The Journal of biological chemistry High 21454613
2015 NDRG1 physically associates with γ-tubulin (centrosome component) and regulates centrosome number and amplification downstream of p53 in low-proliferative states; NDRG1 loss leads to centrosome amplification and genomic instability. Co-immunoprecipitation (NDRG1-γ-tubulin), RNAi and overexpression in isogenic TP53 WT/null/mutant cells, centrosome counting, genomic analysis Proceedings of the National Academy of Sciences of the United States of America High 26324937
2015 NDRG1 is post-translationally modified by SUMO-2 predominantly at Lys14; SUMO-2 modification influences NDRG1 protein stability (a SUMO-2 fused NDRG1 K14R mutant shows dramatically decreased stability) without affecting subcellular distribution. SUMO-2-fused NDRG1 K14R also downregulates p21 expression. SUMO modification assays, NDRG1 mutant (K14R) construction, protein stability assays, subcellular fractionation, Western blot Biochemical and biophysical research communications Medium 25712528
2015 Ndrg1 is an anergy factor in T cells induced by the transcription factor Egr2; Ndrg1 is phosphorylated and degraded via the proteasome upon CD28 costimulation and IL-2 treatment; Ndrg1-deficient T cells fail to become anergic and show hyperresponsiveness. Ndrg1 knockout mice, Ndrg1 overexpression, proteasome inhibitor treatment, T-cell anergy induction assays, autoimmune inflammation models Nature communications High 26507712
2007 NDRG1 deficiency in mice impairs mast cell maturation and degranulation: Ndrg1-knockout mast cells show defective exocytosis (degranulation) after FcεRI crosslinking under CTMC-like maturation conditions, while leukotriene and cytokine production are unaffected. Ndrg1 knockout mouse, ex vivo bone marrow-derived mast cell (BMMC) co-culture with fibroblasts, FcεRI crosslinking assay, IgE-mediated anaphylaxis models Journal of immunology High 17513753
2006 17β-estradiol (E2) decreases Cap43/NDRG1 expression dose-dependently through an estrogen receptor-α (ERα)-dependent pathway; overexpression of ERα in ER-negative cell lines is sufficient to downregulate Cap43, and anti-estrogens reverse this effect. Real-time PCR, immunoblotting, ERα cDNA transfection in ER-negative lines, anti-estrogen (tamoxifen, ICI 182780) treatment Clinical cancer research Medium 16707596
2007 p53-dependent NDRG1 expression (induced by polyamine depletion) inhibits intestinal epithelial cell proliferation (DNA synthesis and cell number) without inducing apoptosis; NDRG1 overexpression inhibits growth regardless of endogenous p53, and p53-binding sites in the NDRG1 proximal promoter mediate this induction. p53 siRNA, p53 knockout cells, NDRG1 promoter deletion analysis, ectopic ODC overexpression, DNA synthesis assay, flow cytometry, TNF-α/cycloheximide apoptosis assay American journal of physiology. Cell physiology High 17442733
2013 HIF-1α binds directly to the NDRG1 promoter (critical region −1202 to −450) to activate NDRG1 expression, and NDRG1 overexpression promotes proliferation and reduces apoptosis in A549 lung cancer cells. Promoter cloning and reporter assay, HIF-1α CDS overexpression, stable NDRG1 transfection, MTT assay, colony formation, flow cytometry Molecular biology reports Medium 23526365
2013 SGK1 phosphorylates NDRG1 at serine/threonine sites; phospho-NDRG1 is increased in Alzheimer's disease brain tissue (~2-fold), suggesting augmented SGK1 activity targeting NDRG1 in AD. Immunoblot with phospho-specific NDRG1 antibody (SGK1-specific target), human post-mortem brain tissue analysis Neuropathology and applied neurobiology Low 23363009
2017 NDRG1 inhibits EGFR/HER2 and HER2/HER3 heterodimer formation and promotes EGFR degradation, thereby attenuating ErbB oncogenic signaling. Co-immunoprecipitation, NDRG1 overexpression/knockdown, receptor dimerization assays, Western blot for receptor degradation The Journal of biological chemistry Medium 28615452
2019 GSK3β phosphorylates serine and threonine residues in the C-terminal domain of NDRG1 and reduces NDRG1 protein stability. Conversely, NDRG1 overexpression decreases GSK3β levels via proteasomal degradation and suppresses AKT/S6 and cell-cycle signaling, revealing a bidirectional regulatory loop. GSK3β inhibitor treatment, NDRG1 overexpression/knockdown, proteasome inhibitor assays, Western blot for pathway targets, in vivo xenograft models Cancer research Medium 31723002
2021 NDRG1 promotes interaction of the androgen receptor (AR) with chaperone HSP90, stabilizing AR while decreasing its androgen-mediated activation; NDRG1 also suppresses AR transcriptional activity partly by inhibiting c-Jun-AR interaction via reduced c-Jun phosphorylation. The CAP domain of NDRG1 is identified as vital for inhibition of AR activity. Co-immunoprecipitation (AR-HSP90), NDRG1 overexpression/knockdown, CAP-domain deletion mutants, AR transcriptional reporter assay, PSA expression analysis The Journal of biological chemistry High 34785213
2021 Crystal structure of the α/β hydrolase domain of human NDRG1 was determined (PDB: 6ZMM); full-length NDRG1 has a flexible N- and C-terminal region; NDRG1 binds to lipid vesicles with conformational changes in the C-terminal region; NDRG1 interacts with metal ions (e.g., nickel) but aggregates in their presence. X-ray crystallography (PDB 6ZMM), small-angle X-ray scattering (SAXS), CD spectroscopy, lipid vesicle binding assays The FEBS journal High 33305529
2017 NDRG1 loss disrupts the binding between RhoGDIα and CDC42, triggering CDC42 activation and downstream PAK1/Cofilin signaling, promoting filopodia formation and colorectal cancer invasiveness. NDRG1 silencing/overexpression, CDC42 activity assay (pull-down), Co-IP (RhoGDIα-CDC42), Western blot for PAK1/Cofilin, in vivo metastasis model International journal of biological sciences Medium 33994856
2017 NDRG1 deficiency reduces active RhoA and Rac1 GTPases while upregulating active Cdc42; NDRG1-deficient prostate cancer cells have restricted actin dynamics (measured by fluorescent polymerized-actin sensor), reduced integrin expression and adhesion, increased EMMPRIN expression with altered glycosylation, increased matrix metalloproteases, and collective invasion phenotype. NDRG1 KD, Rho GTPase activity assays, live-cell fluorescent actin imaging (FRAP), EMMPRIN glycosylation analysis, 3D invasion assay, in vivo xenograft metastasis assay Molecular oncology High 28371345
2021 NDRG1 enhances cetuximab (EGFR antibody) sensitivity in colorectal cancer by reducing EGFR expression, blocking EGFR phosphorylation, reducing EGFR at the cell membrane, and attenuating endocytosis/degradation of EGFR induced by caveolin-1 (Cav1). NDRG1 overexpression/knockdown, EGFR distribution analysis (membrane/cytoplasm/nuclear fractions), caveolin-1 co-immunoprecipitation, in vivo xenograft and patient tissue Oncogene Medium 34385595
2020 NDRG1 forms a complex with PLCγ1 through its phosphorylation sites and is required for VEGF-A-induced PLCγ1 and ERK1/2 activation in endothelial cells; Ndrg1-knockout mice display impaired VEGF-A-induced corneal angiogenesis and reduced aortic sprouting. Co-immunoprecipitation (NDRG1-PLCγ1), Ndrg1 knockout mice, corneal angiogenesis assay, aortic ring sprouting assay, Western blot for PLCγ1/ERK activation, dorsal air sac assay Communications biology High 32144393
2022 NDRG1 interacts with the orphan nuclear receptor Nur77 and functionally inhibits Nur77 transcriptional activity and NF-κB activity in endothelial cells; NDRG1 knockdown attenuates cytokine-induced MAPK activation, c-Jun phosphorylation, and AP-1 transcriptional activity. Endothelial cell-specific NDRG1 knockout mice show reduced neointima formation, atherosclerosis, and arterial thrombosis. Co-immunoprecipitation (NDRG1-Nur77), lentiviral shRNA knockdown, endothelial-specific NDRG1 KO mice, carotid artery ligation model, Nur77/NF-κB reporter assays, Western blot Circulation research High 36562299
2023 Fasting or lipid availability activates mTORC2, which phosphorylates NDRG1 at Ser336; phosphorylated NDRG1 engages mitochondria and facilitates mitochondrial fission by cooperating with CDC42 and its effectors/regulators. The phosphorylation-deficient NDRG1-Ser336Ala mutant fails to support fission. Time-lapse imaging of NDRG1-mitochondria interaction, phospho-deficient mutant (NDRG1-S336A), siRNA screen, epistasis with DRP1-KO cells, proteomics, CDC42 co-immunoprecipitation, RictorKO and Cdc42-KO phenotyping Nature cell biology High 37386153
2019 NDRG1 directly interacts with MIG6 (a tumor suppressor/EGFR regulator) and regulates c-Cbl E3 ligase activity as part of its mechanism for inhibiting receptor tyrosine kinases. Co-immunoprecipitation (NDRG1-MIG6), NDRG1 overexpression studies Cells Low 34572031
2017 MNK1 (but not MNK2) signaling regulates NDRG1 phosphorylation; however, MNK1 cannot directly phosphorylate NDRG1 in vitro, indicating an indirect mechanism. MNK inhibition increases NDRG1 protein and mRNA expression. SGK1 phosphorylates MNK1 at a conserved site to repress its activity. MNK1/2 knockout cells, in vitro kinase assay (MNK1 vs. NDRG1), MNK inhibitors, SGK1 kinase assay on MNK1, Western blot Oncotarget Medium 28545025
2019 NDRG1 regulates all three main arms of the ER stress response: increases ER chaperone expression (BiP, calreticulin, calnexin), suppresses PERK and IRE1α arms, and increases ATF6 cleavage. In the presence of anti-cancer agent Dp44mT, NDRG1 markedly increases eIF2α activation, maintains ATF4, elevates cytosolic Ca2+, and increases pro-apoptotic CHOP. NDRG1 overexpression/knockdown in pancreatic and colon cancer cells, Western blot for ER stress markers, Ca2+ measurement, confocal microscopy Biochimica et biophysica acta. Molecular basis of disease Medium 30981813
2019 NDRG1 facilitates KSHV genome replication and episome persistence by interacting directly with PCNA (proliferating cell nuclear antigen) and forming a ternary complex with LANA (viral latent protein) and PCNA, bridging LANA to PCNA at viral terminal repeats (TRs) to facilitate viral DNA replication. Co-immunoprecipitation (NDRG1-PCNA, LANA-NDRG1-PCNA complex), NDRG1 knockdown in KSHV-infected cells, viral genome copy number assay, chromatin immunoprecipitation of PCNA at viral TRs PLoS pathogens High 30811506
2020 NDRG1 suppresses autophagy at both the initiation stage and autolysosome formation (reducing LC3-LAMP2 co-localization, increasing p62); NDRG1 expression decreases cholesterol levels (independent of AMPK), sensitizing lysosomes to membrane permeabilization. NDRG1 overexpression/knockdown, confocal microscopy (LC3/LAMP2 co-localization), p62 Western blot, cholesterol determination, acridine orange staining for LMP, AMPK phosphorylation assays Biochimica et biophysica acta. General subjects Medium 32335136
2018 NDRG1 regulates neutral lipid metabolism and lipid droplet formation in breast cancer cells; NDRG1 silencing increases fatty acid incorporation into neutral lipids and lipid droplets, while NDRG1 expression minimizes lipid droplet formation under both nutrient-replete and starvation conditions. NDRG1 silencing/overexpression, comprehensive lipidomics mass spectrometry, labeled fatty acid tracking, high-throughput quantitative microscopy, multiple breast cancer cell lines Breast cancer research High 29898756
2017 Ndrg1 promotes adipocyte differentiation by inducing PPARγ expression and is required for C/EBPα phosphorylation; SGK1-dependent phosphorylation of Ndrg1 is induced during adipogenesis and promotes adipocyte formation. Ndrg1 knockdown/overexpression in adipocyte precursor cells, PPARγ and C/EBPα Western blot, adipogenesis differentiation assay Scientific reports Medium 28775290
2024 NSUN6-mediated m5C methylation of NDRG1 mRNA enhances its stability via the m5C reader ALYREF; elevated NDRG1 expression promotes homologous recombination-mediated DNA repair, contributing to radioresistance in cervical cancer. Integrated m5C sequencing, mRNA sequencing, RNA immunoprecipitation, NSUN6 overexpression/silencing, CDX and 3D PDO models, in vivo xenograft Molecular cancer High 38970106
2021 c-Jun, AR (androgen receptor), and DNMT1 form a complex at TRE regions of the NDRG1 promoter and suppress NDRG1 transcription through DNA hypermethylation; N-cadherin promotes c-Jun expression to suppress NDRG1, establishing an N-cadherin/c-Jun/NDRG1 axis in prostate cancer progression. Co-immunoprecipitation (c-Jun/AR/DNMT1 complex), ChIP at NDRG1 promoter TRE region, bisulfite sequencing for promoter methylation, NDRG1 knockdown/overexpression, in vivo xenograft International journal of biological sciences Medium 34512147
2022 KDM1A (LSD1) histone demethylase represses NDRG1 expression; de-repression of NDRG1 by KDM1A inhibition causes inhibition of Wnt signaling and G1 cell cycle arrest in gastric cancer patient-derived organoids. CRISPR/Cas9 viability screen in patient-derived organoids, KDM1A genetic and pharmacological inhibition, NDRG1 expression measurement, cell cycle analysis, Wnt signaling assays Small methods Medium 36908010
2022 Ndrg1a in zebrafish binds to the sodium-potassium ATPase (NKA) pump under anoxia and is required for NKA degradation, preserving ATP in kidney and ionocytes during hypoxia; sodium azide (which increases lactate) triggers NKA degradation in an Ndrg1a-dependent manner. Ndrg1a knockout zebrafish, co-immunoprecipitation (Ndrg1a-NKA), sodium azide treatment, anoxia survival assays, kidney function assays eLife High 36214665
2023 MAOA interacts with NDRG1 and together they regulate glycolysis (Warburg effect) through suppression of the PI3K/AKT/mTOR pathway in gastric cancer. Co-immunoprecipitation (MAOA-NDRG1), Seahorse assay for glycolysis, Western blot for PI3K/AKT/mTOR pathway, overexpression/knockdown studies Cellular oncology Low 37249744
2018 HER4 interacts with NDRG1 in osteosarcoma cells; NDRG1 overexpression antagonizes HER4 knockdown-mediated cell growth inhibition and apoptosis under stress conditions. Co-immunoprecipitation (HER4-NDRG1), shRNA knockdown of HER4, NDRG1 overexpression rescue assay, immunohistochemistry Biochimica et biophysica acta. Molecular basis of disease Low 29524631
2024 NDRG1 inhibits ATG9A-dependent lysosomal-autophagy degradation of MHC class I (MHC-1) in pancreatic ductal adenocarcinoma cells, maintaining MHC-1 surface expression; elevated NDRG1 promotes CD8+ T cell infiltration and overcomes immune checkpoint blockade resistance. NDRG1 knockdown/overexpression, autophagy inhibitor studies, co-immunoprecipitation (NDRG1-ATG9A pathway), flow cytometry for MHC-1 and T cells, in vivo orthotopic mouse models, multiplex immunofluorescence Drug resistance updates Medium 38228036
2025 NDRG1 stabilizes LDHA by inhibiting its ubiquitination, thereby enhancing glycolysis and promoting lactate accumulation in lung adenocarcinoma; histone H2B K58 lactylation at the NDRG1 locus (mediated by LDHA-generated lactate) represents an epigenetic feedback mechanism. NDRG1 knockdown/overexpression, ubiquitination assay (LDHA ubiquitylation), Seahorse glycolysis assay, lactate measurement, histone lactylation ChIP Advanced science Medium 40539245
2016 NDRG1 physically associates with TLE2 and β-catenin to activate Wnt/β-catenin signaling in esophageal squamous cell carcinoma, promoting EMT; TLE2 overexpression prevents NDRG1-driven Wnt pathway activation. Co-immunoprecipitation (NDRG1-TLE2, NDRG1-β-catenin), stable lentiviral overexpression, RNAi, TLE2 overexpression epistasis, Western blot for EMT markers Cancer biology & therapy Low 27414086
2020 NDRG1 binds directly to PI3K (co-immunoprecipitation) in placental JEG-3 cells; NDRG1 knockdown upregulates PI3K and AKT expression, identifying PI3K/AKT as a downstream mechanism of NDRG1-mediated suppression of angiogenesis. Co-immunoprecipitation (NDRG1-PI3K), lentiviral NDRG1 overexpression/knockdown, ELISA for PLGF/sFlt-1, Western blot for PI3K/AKT/VEGF, tube formation assay Pregnancy hypertension Low 32470876
2022 In triple-negative breast cancer, YAP1 positively regulates NDRG1 transcription by binding the NDRG1 promoter; HJURP affects YAP1 ubiquitination and degradation, thereby modulating NDRG1 expression via the HJURP/YAP1/NDRG1 axis. YAP1 ChIP at NDRG1 promoter, ubiquitination assay (YAP1), HJURP knockdown/overexpression, Western blot, cell proliferation and chemosensitivity assays Cell death & disease Medium 35459269
2011 NDRG1/Cap43 overexpression in hepatocellular carcinoma cells induces G0/G1 cell cycle arrest accompanied by increased p21 and decreased CDK4 expression both in vitro and in vivo. Stable NDRG1 transfection, cell cycle analysis (flow cytometry), Western blot for p21/CDK4, in vivo xenograft tumor growth, mimosine-induced G0/G1 block Cancer letters Medium 21775055
2009 NDRG1 regulates endothelial cell migration under intermittent hypoxia: siRNA silencing of NDRG1 decreases endothelial cell migration under intermittent hypoxia (as identified by 2D-DIGE proteomics and confirmed by siRNA). 2D-DIGE proteomics, mass spectrometry protein identification, siRNA knockdown, endothelial cell migration assay Angiogenesis Low 19760510
2022 PTK7 (a membrane-localized pseudokinase) interacts with and stabilizes NDRG1 adjacent to adherens junctions; downregulation of either PTK7 or NDRG1 eliminates AZD9291 resistance in NSCLC cells. BioID proximal labeling (BirA*-PTK7), Co-immunoprecipitation (PTK7-NDRG1), knockdown/overexpression, phospho- and proximal proteomics ACS chemical biology Medium 36205702

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 Cap43, a novel gene specifically induced by Ni2+ compounds. Cancer research 212 9605764
2004 NDRG1 is necessary for p53-dependent apoptosis. The Journal of biological chemistry 187 15377670
2002 Expression of NDRG1, a differentiation-related gene, in human tissues. Histochemistry and cell biology 173 12432451
2006 The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer. Carcinogenesis 171 16920733
2013 mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy. Proceedings of the National Academy of Sciences of the United States of America 154 24367102
2004 Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers. BMC genetics 154 15341671
2006 Tumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesis. Cancer research 138 16778198
2013 Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy. Biochimica et biophysica acta 129 24269900
2013 Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors. Carcinogenesis 121 23671130
2009 N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression. Cancer research 88 19491262
2013 The role of NDRG1 in the pathology and potential treatment of human cancers. Journal of clinical pathology 82 23750037
2011 KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer. The Journal of biological chemistry 80 21454613
2018 NDRG1 regulates neutral lipid metabolism in breast cancer cells. Breast cancer research : BCR 76 29898756
2019 Pharmacological targeting and the diverse functions of the metastasis suppressor, NDRG1, in cancer. Free radical biology & medicine 74 31132412
2010 Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells. Biochemical and biophysical research communications 72 20416281
2013 NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation. Journal of cell science 71 23813961
1997 Cloning and characterization of TDD5, an androgen target gene that is differentially repressed by testosterone and dihydrotestosterone. Proceedings of the National Academy of Sciences of the United States of America 67 9144177
2004 Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Cancer research 65 14729612
2003 Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells. International journal of cancer 63 12767066
2022 NDRG1 Signaling Is Essential for Endothelial Inflammation and Vascular Remodeling. Circulation research 61 36562299
2009 Decreased expression of NDRG1 in glioma is related to tumor progression and survival of patients. Journal of neuro-oncology 60 19337694
2001 High expression of the Cap43 gene in infiltrating macrophages of human renal cell carcinomas. Clinical cancer research : an official journal of the American Association for Cancer Research 57 11448934
2011 Ndrg1 in development and maintenance of the myelin sheath. Neurobiology of disease 55 21303696
2009 N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin. Human pathology 53 19800102
2024 NSUN6-mediated 5-methylcytosine modification of NDRG1 mRNA promotes radioresistance in cervical cancer. Molecular cancer 52 38970106
2013 HIF-1α up-regulates NDRG1 expression through binding to NDRG1 promoter, leading to proliferation of lung cancer A549 cells. Molecular biology reports 52 23526365
2013 The cell survival kinase SGK1 and its targets FOXO3a and NDRG1 in aged human brain. Neuropathology and applied neurobiology 51 23363009
2022 NDRG1 in Cancer: A Suppressor, Promoter, or Both? Cancers 49 36497221
2010 Hypoxia and retinoic acid-inducible NDRG1 expression is responsible for doxorubicin and retinoic acid resistance in hepatocellular carcinoma cells. Cancer letters 49 20573444
2012 NDRG1/Cap43/Drg-1 may predict tumor angiogenesis and poor outcome in patients with lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 48 22481237
2020 NDRG1-PLAG1 and TRPS1-PLAG1 Fusion Genes in Chondroid Syringoma. Cancer genomics & proteomics 44 32345665
2017 Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling. The Journal of biological chemistry 44 28615452
2013 Quantitative analysis of BTF3, HINT1, NDRG1 and ODC1 protein over-expression in human prostate cancer tissue. PloS one 44 24386364
2011 Phosphorylation of NDRG1 is temporally and spatially controlled during the cell cycle. Biochemical and biophysical research communications 44 21708134
2021 The Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity. Cells 43 34572031
2016 NDRG1 overexpression promotes the progression of esophageal squamous cell carcinoma through modulating Wnt signaling pathway. Cancer biology & therapy 43 27414086
2007 Impaired mast cell maturation and degranulation and attenuated allergic responses in Ndrg1-deficient mice. Journal of immunology (Baltimore, Md. : 1950) 43 17513753
2023 mTORC2-NDRG1-CDC42 axis couples fasting to mitochondrial fission. Nature cell biology 42 37386153
2007 p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion. American journal of physiology. Cell physiology 42 17442733
2006 17Beta-estradiol induces down-regulation of Cap43/NDRG1/Drg-1, a putative differentiation-related and metastasis suppressor gene, in human breast cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research 42 16707596
2005 NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24. Biochemical and biophysical research communications 41 15922294
2009 NDRG1/2 expression is inhibited in primary acute myeloid leukemia. Leukemia research 40 19775754
2008 N-myc downstream regulated gene 1 (NDRG1)/Cap43 enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma. Oncology reports 39 19020710
2001 Ni(II) and Cu(II) binding with a 14-aminoacid sequence of Cap43 protein, TRSRSHTSEGTRSR. Journal of inorganic biochemistry 39 11330481
2022 NDRG1 in Aggressive Breast Cancer Progression and Brain Metastasis. Journal of the National Cancer Institute 38 34893874
2007 Immunohistochemical expressions of Cap43 and Mina53 proteins in neuroblastoma. Journal of pediatric surgery 37 18022432
2023 MAOA suppresses the growth of gastric cancer by interacting with NDRG1 and regulating the Warburg effect through the PI3K/AKT/mTOR pathway. Cellular oncology (Dordrecht, Netherlands) 36 37249744
2003 Identification and characterization of Xenopus NDRG1. Biochemical and biophysical research communications 36 12943662
2019 Long noncoding RNA CCAT2 promotes hepatocellular carcinoma proliferation and metastasis through up-regulation of NDRG1. Experimental cell research 35 30922920
2017 The prostate metastasis suppressor gene NDRG1 differentially regulates cell motility and invasion. Molecular oncology 35 28371345
2015 Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2. Nature communications 34 26507712
2003 Cellular distribution of NDRG1 protein in the rat kidney and brain during normal postnatal development. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 34 14566023
2021 NDRG1 regulates Filopodia-induced Colorectal Cancer invasiveness via modulating CDC42 activity. International journal of biological sciences 33 33994856
2014 MicroRNA-769-3p down-regulates NDRG1 and enhances apoptosis in MCF-7 cells during reoxygenation. Scientific reports 33 25081069
2021 NDRG1 enhances the sensitivity of cetuximab by modulating EGFR trafficking in colorectal cancer. Oncogene 32 34385595
2020 NDRG1 activates VEGF-A-induced angiogenesis through PLCγ1/ERK signaling in mouse vascular endothelial cells. Communications biology 32 32144393
2020 Hypoxia-induced elevated NDRG1 mediates apoptosis through reprograming mitochondrial fission in HCC. Gene 32 32165297
2019 Bidirectional Regulation between NDRG1 and GSK3β Controls Tumor Growth and Is Targeted by Differentiation Inducing Factor-1 in Glioblastoma. Cancer research 31 31723002
2015 NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability. Proceedings of the National Academy of Sciences of the United States of America 30 26324937
2022 HJURP regulates cell proliferation and chemo-resistance via YAP1/NDRG1 transcriptional axis in triple-negative breast cancer. Cell death & disease 29 35459269
2021 The metastasis suppressor NDRG1 directly regulates androgen receptor signaling in prostate cancer. The Journal of biological chemistry 29 34785213
2017 Ndrg1 promotes adipocyte differentiation and sustains their function. Scientific reports 28 28775290
2015 Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43. Acta pharmaceutica Sinica. B 28 26713269
2017 NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy. Cell death & disease 27 28906492
2021 Crystal and solution structure of NDRG1, a membrane-binding protein linked to myelination and tumour suppression. The FEBS journal 26 33305529
2013 Aberrant NDRG1 methylation associated with its decreased expression and clinicopathological significance in breast cancer. Journal of biomedical science 26 23899187
2020 GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy. BMC cancer 25 32106831
2019 The metastasis suppressor, NDRG1, differentially modulates the endoplasmic reticulum stress response. Biochimica et biophysica acta. Molecular basis of disease 25 30981813
2010 N-myc downstream-regulated gene 1/Cap43 expression promotes cell differentiation of human osteosarcoma cells. Oncology reports 25 20664979
2008 Correlation between NDRG1 and PTEN expression in endometrial carcinoma. Cancer science 25 18377423
2023 CRISPR/Cas9 Screen in Gastric Cancer Patient-Derived Organoids Reveals KDM1A-NDRG1 Axis as a Targetable Vulnerability. Small methods 24 36908010
2011 N-myc downstream regulated gene1/Cap43 overexpression suppresses tumor growth by hepatic cancer cells through cell cycle arrest at the G0/G1 phase. Cancer letters 24 21775055
2009 NDRG1 and CRK-I/II are regulators of endothelial cell migration under Intermittent Hypoxia. Angiogenesis 24 19760510
2017 Time- and oxygen-dependent expression and regulation of NDRG1 in human brain cancer cells. Oncology reports 23 28498432
2025 NDRG1-Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 22 40539245
2024 NDRG1 overcomes resistance to immunotherapy of pancreatic ductal adenocarcinoma through inhibiting ATG9A-dependent degradation of MHC-1. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 22 38228036
2021 The role of N-cadherin/c-Jun/NDRG1 axis in the progression of prostate cancer. International journal of biological sciences 22 34512147
2020 LINC01419 promotes cell proliferation and metastasis in hepatocellular carcinoma by enhancing NDRG1 promoter activity. Cellular oncology (Dordrecht, Netherlands) 22 32557341
2018 HER4 promotes cell survival and chemoresistance in osteosarcoma via interaction with NDRG1. Biochimica et biophysica acta. Molecular basis of disease 22 29524631
2023 The role of the NDRG1 in the pathogenesis and treatment of breast cancer. Biochimica et biophysica acta. Reviews on cancer 21 36841367
2018 Histone Deacetylase Inhibition Restores Expression of Hypoxia-Inducible Protein NDRG1 in Pancreatic Cancer. Pancreas 21 29303911
2015 SUMO modification regulates the protein stability of NDRG1. Biochemical and biophysical research communications 21 25712528
2004 Nickel(II) binding to Cap43 protein fragments. Journal of inorganic biochemistry 21 15149799
2025 Lactate drives senescence-resistant lineages in hepatocellular carcinoma via histone H2B lactylation of NDRG1. Cancer letters 20 39978571
2018 NDRG1 Downregulates ATF3 and Inhibits Cisplatin-Induced Cytotoxicity in Lung Cancer A549 Cells. International journal of medical sciences 20 30443171
2017 Increased NDRG1 expression attenuate trophoblast invasion through ERK/MMP-9 pathway in preeclampsia. Placenta 20 28292472
2022 Proteomic and Phosphoproteomic Analyses Reveal the Oncogenic Role of PTK7-NDRG1 Axis in Non-small-cell Lung Cancer Cell Resistance to AZD9291. ACS chemical biology 19 36205702
2018 Different effects of long noncoding RNA NDRG1-OT1 fragments on NDRG1 transcription in breast cancer cells under hypoxia. RNA biology 19 30497328
2023 The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics. Pharmacological reviews 18 37280098
2022 N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia. eLife 18 36214665
2020 NDRG1 suppresses basal and hypoxia-induced autophagy at both the initiation and degradation stages and sensitizes pancreatic cancer cells to lysosomal membrane permeabilization. Biochimica et biophysica acta. General subjects 18 32335136
2020 Increased NDRG1 expression suppresses angiogenesis via PI3K/AKT pathway in human placental cells. Pregnancy hypertension 18 32470876
2019 NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA. PLoS pathogens 18 30811506
2015 NDRG1 overexpressing gliomas are characterized by reduced tumor vascularization and resistance to antiangiogenic treatment. Cancer letters 18 26297987
2023 Role of KLF4/NDRG1/DRP1 axis in hypoxia-induced pulmonary hypertension. Biochimica et biophysica acta. Molecular basis of disease 17 37356737
2021 MiR-188-3p and miR-133b Suppress Cell Proliferation in Human Hepatocellular Carcinoma via Post-Transcriptional Suppression of NDRG1. Technology in cancer research & treatment 17 34355586
2020 LINC00844 promotes proliferation and migration of hepatocellular carcinoma by regulating NDRG1 expression. PeerJ 17 32025371
2017 Oncogenic MNK signalling regulates the metastasis suppressor NDRG1. Oncotarget 17 28545025
2008 Preclinical and clinical studies of novel breast cancer drugs targeting molecules involved in protein kinase C signaling, the putative metastasis-suppressor gene Cap43 and the Y-box binding protein-1. Current medicinal chemistry 16 18336267
2018 NDRG1 and FOXO1 regulate endothelial cell proliferation in infantile haemangioma. Experimental dermatology 15 29569762

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