Affinage

NCAPG

Condensin complex subunit 3 · UniProt Q9BPX3

Length
1015 aa
Mass
114.3 kDa
Annotated
2026-04-29
66 papers in source corpus 21 papers cited in narrative 21 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NCAPG is a HEAT-repeat subunit of the condensin I complex that functions as the rate-limiting component for condensin I assembly, with its protein levels peaking in mitosis and declining in G1 through regulated transcription and constitutive degradation (PMID:27463097). Cdc2/cyclin B phosphorylates NCAPG at Thr308 and Thr332 to direct its chromosomal localization during mitosis, and NCAPG associates exclusively with condensin I (not condensin II), physically interacting with the centromeric histone CENP-A to ensure proper sister chromatid segregation (PMID:18977199, PMID:15592865, PMID:23637630). Loss of NCAPG causes aberrant mitotic divisions, mitochondrial fragmentation, and cell death, and genome-wide CRISPR screens identify it as essential for hepatocellular carcinoma cell survival (PMID:31022357). Beyond its canonical mitotic role, NCAPG promotes oncogenic signaling in multiple cancer types by engaging the PI3K/AKT pathway via CKII-mediated PTEN phosphorylation, activating Wnt/β-catenin signaling through direct β-catenin binding, and conferring ferroptosis resistance by stabilizing NSUN2 to upregulate GPX4 through m5C mRNA modification (PMID:35864529, PMID:35292013, PMID:41260238).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2004 High

    Establishing that NCAPG links condensin I to centromere/kinetochore function resolved how the complex contributes to sister chromatid segregation beyond simple chromosome condensation.

    Evidence Drosophila Cap-G mutant embryos plus yeast two-hybrid showing physical interaction with centromeric histone CID/CENP-A

    PMID:15592865

    Open questions at the time
    • Whether the NCAPG–CENP-A interaction is conserved in vertebrates
    • Residues mediating the NCAPG–CENP-A contact not mapped
    • How condensin I at centromeres mechanistically promotes faithful segregation
  2. 2008 High

    Identifying cdc2/cyclin B phosphorylation of NCAPG at Thr308/Thr332 as required for chromosomal targeting established the key cell-cycle-dependent regulatory switch for condensin I localization.

    Evidence In vitro kinase assay with cdc2/cyclin B, T308A/T332A mutagenesis, immunofluorescence during mitosis

    PMID:18977199

    Open questions at the time
    • Whether phosphorylation affects NCAPG interaction with kleisin or other subunits
    • Phosphatase(s) responsible for dephosphorylation not identified
  3. 2013 High

    Demonstrating exclusive NCAPG association with condensin I, not condensin II, clarified the subunit composition distinguishing the two complexes and showed that nuclear enrichment during interphase is dispensable for condensin I assembly.

    Evidence Co-IP, mass spectrometry, EGFP-fusion live imaging, and in vitro reconstitution in Drosophila

    PMID:23637630

    Open questions at the time
    • Whether vertebrate NCAPG exhibits any transient condensin II association
    • Function of interphase nuclear NCAPG pool remains unclear
  4. 2016 High

    Identifying NCAPG (Ycg1) as the rate-limiting subunit for condensin complex formation revealed how cells restrict condensin activity to mitosis through regulated Ycg1 abundance.

    Evidence Cell-cycle protein level analysis, overexpression and stabilization mutants, chromatin fractionation in budding yeast

    PMID:27463097

    Open questions at the time
    • Whether this stoichiometric bottleneck is conserved in mammalian cells
    • Degradation pathway (E3 ligase) for Ycg1/NCAPG turnover not identified
  5. 2019 High

    SAXS analysis of Ycg1 revealed that NCAPG is conformationally flexible in isolation but rigidifies upon binding its kleisin partner, providing the first structural evidence for an allosteric activation mechanism within condensin I.

    Evidence Small-angle X-ray scattering and multiangle light scattering of purified Ycg1 ± Brn1

    PMID:31350339

    Open questions at the time
    • No high-resolution structure of NCAPG alone or in complex at the time
    • Whether oligomerization of free NCAPG has physiological relevance
  6. 2019 High

    Genome-wide CRISPR screens and functional studies established NCAPG as essential for cancer cell viability, linking its canonical mitotic role to tumor dependency through aberrant mitosis, mitochondrial fragmentation, and cell death upon depletion.

    Evidence CRISPR depletion screen in HCC cells, siRNA knockdown with live-cell imaging, xenograft validation

    PMID:31022357

    Open questions at the time
    • Whether essentiality reflects purely mitotic functions or additional interphase roles
    • Mitochondrial fragmentation mechanism not molecularly defined
  7. 2019 Medium

    Linking NCAPG overexpression to PI3K/AKT/FOXO4 pathway activation in HCC established the first oncogenic signaling axis attributed to NCAPG beyond its structural mitotic role.

    Evidence RNA-seq, PI3K inhibitor/activator rescue experiments, EdU proliferation and xenograft assays in HCC cells

    PMID:31802891

    Open questions at the time
    • Direct biochemical mechanism connecting NCAPG to PI3K activation was unresolved
    • FOXO4 involvement based on downstream correlations only
  8. 2020 Medium

    Placing NCAPG upstream of SRC phosphorylation and STAT3 nuclear translocation in trastuzumab-resistant breast cancer expanded the oncogenic repertoire of NCAPG to drug resistance mechanisms.

    Evidence siRNA/overexpression, p-SRC and nuclear STAT3 western blot in HER2+ breast cancer cells and xenografts

    PMID:32683421

    Open questions at the time
    • Direct kinase activity of NCAPG toward SRC not demonstrated
    • Whether NCAPG acts as scaffold or enzyme in this context is unknown
  9. 2022 Medium

    Identification of CKII as a physical interactor of NCAPG that phosphorylates PTEN to activate PI3K/AKT resolved the mechanistic gap in how NCAPG engages the PI3K pathway.

    Evidence IP-mass spectrometry, Co-IP, PTEN phosphorylation assays, transcriptome sequencing in HCC

    PMID:35864529

    Open questions at the time
    • Whether NCAPG activates CKII or simply recruits it to PTEN
    • Single-lab finding awaiting independent confirmation
  10. 2022 Medium

    Showing NCAPG directly binds β-catenin to activate Wnt signaling and EMT in colorectal cancer revealed a distinct oncogenic mechanism operating through a canonical developmental pathway.

    Evidence Co-IP, immunofluorescence, migration/invasion assays with Wnt pathway component analysis in CRC cells

    PMID:35292013

    Open questions at the time
    • Binding interface between NCAPG and β-catenin not resolved
    • Whether this interaction occurs in normal physiology or is cancer-specific
  11. 2023 Medium

    Demonstrating E2F1 transcriptional activation of NCAPG by direct promoter binding connected NCAPG upregulation in cancer to the Rb/E2F cell-cycle regulatory axis.

    Evidence ChIP and dual luciferase reporter assay on NCAPG promoter in HCC cells

    PMID:38250463

    Open questions at the time
    • Whether E2F1 is the dominant transcriptional driver of NCAPG across cancer types
    • Relative contribution of E2F1 vs. other regulators (CREB1, MYOD1) not compared
  12. 2025 Medium

    Mapping the NCAPG–NSUN2 interaction to residues 446–460 and linking it to m5C-mediated GPX4 mRNA stabilization established a non-canonical epitranscriptomic mechanism by which NCAPG confers ferroptosis resistance.

    Evidence Co-IP with domain mapping mutagenesis, m5C modification assay, mRNA stability assays, ferroptosis rescue experiments in HCC

    PMID:41260238

    Open questions at the time
    • Whether NCAPG stabilizes NSUN2 by blocking a specific E3 ligase
    • Generalizability of this ferroptosis resistance mechanism beyond HCC
  13. 2025 Medium

    Identifying ASPM-mediated nuclear-to-cytoplasmic transport and BUB3-dependent deubiquitination of NCAPG revealed a post-translational regulatory circuit controlling NCAPG stability and its downstream effect on PD-L1 via SRC/STAT3 in gastric cancer.

    Evidence Co-IP, mass spectrometry, molecular docking, CUT&Tag, organoid experiments in gastric cancer

    PMID:40898336

    Open questions at the time
    • The deubiquitinase directly catalyzing NCAPG deubiquitination (BUB3 itself lacks DUB activity) is not identified
    • Whether ASPM-NCAPG transport is mitosis-specific or also occurs in interphase

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major open questions include the high-resolution structural basis of NCAPG within the condensin I holocomplex, the mechanism by which a structural condensin subunit engages diverse cytoplasmic signaling pathways in cancer, and whether NCAPG's oncogenic signaling functions are independent of its condensin I role.
  • No high-resolution structure of human NCAPG in the condensin I holocomplex
  • Separation-of-function mutations distinguishing mitotic vs. oncogenic signaling roles not established
  • Whether NCAPG functions as monomer or condensin-associated in cytoplasmic signaling contexts is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0005198 structural molecule activity 3 GO:0008092 cytoskeletal protein binding 2
Localization
GO:0005694 chromosome 4 GO:0005634 nucleus 2 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 6 R-HSA-1640170 Cell Cycle 4 R-HSA-5357801 Programmed Cell Death 2 R-HSA-4839726 Chromatin organization 1
Partners
ASPMBUB3CDK1CENP-ACKIICTNNB1NSUN2SRC
Complex memberships
condensin I

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 CAP-G (NCAPG) contains two threonine residues (Thr308 and Thr332) that are phosphorylated by cdc2/cyclin B; mutation of these threonines to alanines causes defects in CAP-G localization with chromosomal DNA during mitosis, establishing that cdc2/cyclin B-mediated phosphorylation regulates condensin I localization. In vitro kinase assay with cdc2/cyclin B, site-directed mutagenesis (T308A, T332A), immunofluorescence localization during mitosis Biochemical and biophysical research communications High 18977199
2004 Drosophila Cap-G (NCAPG ortholog) physically interacts with the centromere-specific histone H3 variant CID (CENP-A homolog) as shown by yeast two-hybrid; Cap-G mutant embryos show largely normal chromosome condensation but massive defects in sister chromatid segregation during mitosis, linking condensin I to kinetochore function. Genetic modifier screen (rough-eye phenotype), yeast two-hybrid protein interaction assay, analysis of Cap-G mutant embryos by microscopy Chromosoma High 15592865
2013 Drosophila Cap-G associates exclusively with condensin I and not condensin II; immunoprecipitation and mass spectrometry show Cap-G co-purifies with condensin I-specific subunits (Cap-D2, Cap-H) but not condensin II-specific subunits (Cap-D3, Cap-H2). Nuclear enrichment of Cap-G during interphase is dispensable for chromatin association and condensin I assembly. Co-immunoprecipitation, mass spectrometry, in vivo EGFP-fusion microscopy, in vitro complex reconstitution PLoS genetics High 23637630
2016 In budding yeast, Ycg1 (Cap-G/NCAPG ortholog) is the limiting subunit for condensin complex formation; its protein levels are cell-cycle regulated (peak in mitosis, decrease in G1) via regulated transcription and constitutive degradation. Overexpression of Ycg1 increases condensin complex levels and chromatin binding in G1, causing delayed cell-cycle entry and proliferation defects. Protein level analysis across cell cycle, overexpression and stabilizing mutations, chromatin fractionation, flow cytometry cell-cycle analysis PLoS genetics High 27463097
2019 SAXS analysis of the condensin HEAT-repeat subunit Ycg1 (Cap-G/NCAPG ortholog) reveals it is flexible in solution but becomes rigid upon binding its kleisin partner Brn1; Ycg1 oligomerizes at high concentration in the absence of Brn1. Small-angle X-ray scattering (SAXS), multiangle light scattering, normal mode analysis structural modeling The Journal of biological chemistry High 31350339
2019 NCAPG promotes HCC cell proliferation and inhibits apoptosis through activation of the PI3K/AKT/FOXO4 signaling pathway; RNA-sequencing predicted this pathway, and PI3K inhibitor LY294002 abolished NCAPG-driven proliferation while PI3K activator 740Y-P phenocopied NCAPG overexpression. siRNA knockdown, overexpression, RNA-seq, EdU proliferation assay, flow cytometry apoptosis, western blot, PI3K inhibitor/activator rescue, xenograft in vivo OncoTargets and therapy Medium 31802891
2019 Genome-wide CRISPR knockout screens identified NCAPG as essential for HCC tumor cell survival; siRNA-mediated knockdown caused aberrant mitotic division, mitochondrial network fragmentation, and cell death in vitro, and reduced xenograft tumor growth in vivo. Genome-wide CRISPR depletion screen, siRNA knockdown, live-cell imaging of mitosis, mitochondrial morphology imaging, xenograft tumor model FASEB journal High 31022357
2020 NCAPG confers trastuzumab resistance in HER2+ breast cancer by phosphorylating SRC and enhancing nuclear localization and activation of STAT3, placing NCAPG upstream of the SRC/STAT3 signaling axis. siRNA knockdown, overexpression, western blot for p-SRC and nuclear STAT3, proliferation and apoptosis assays in vitro and in vivo xenograft Cell death & disease Medium 32683421
2020 NCAPG silencing in bovine fetal myoblasts prolongs mitosis and impairs myogenic differentiation through increased apoptosis; ATAC-seq revealed that NCAPG silencing alters chromatin accessibility at AP-1 (FOSL2/JUNB) binding sites, affecting muscle-specific gene expression. siRNA knockdown in primary myoblasts, ATAC-seq chromatin accessibility assay, muscle-specific gene expression analysis, flow cytometry apoptosis International journal of molecular sciences Medium 32070024
2022 NCAPG promotes colorectal cancer invasion and metastasis by directly binding to β-catenin to activate the Wnt/β-catenin signaling pathway, facilitating EMT. Co-immunoprecipitation, immunofluorescence, siRNA knockdown, overexpression, western blot for Wnt pathway components, migration/invasion assays Cancer cell international Medium 35292013
2022 NCAPG promotes HCC cell proliferation through interaction with casein kinase II (CKII); Co-IP and proteomic sequencing confirmed NCAPG-CKII interaction, and CKII phosphorylates PTEN to inhibit its transcription and function, activating the PI3K-AKT pathway. IP-mass spectrometry, proteomic sequencing, Co-immunoprecipitation, transcriptome sequencing, western blot, EdU assay, xenograft model Journal of translational medicine Medium 35864529
2022 NCAPG promotes NSCLC oncogenesis and progression partly through upregulation of LGALS1 (Galectin-1), which may directly interact with NCAPG; Ncapg+/- mice showed reduced urethane-induced lung tumor formation. Transcriptome sequencing, TCGA analysis, IHC, siRNA knockdown, overexpression, in vitro functional assays, Ncapg heterozygous knockout mouse model with urethane carcinogenesis Molecular cancer Medium 35180865
2023 E2F1 transcriptionally activates NCAPG expression in HCC; ChIP and dual luciferase reporter assays demonstrated E2F1 binding to the NCAPG promoter. NCAPG knockdown promotes NLRP3 inflammasome-mediated pyroptosis in HCC cells. Dual luciferase reporter assay, ChIP, siRNA knockdown, scanning electron microscopy of pyroptosis, western blot for NLRP3 complex components, ELISA, xenograft Journal of clinical and translational hepatology Medium 38250463
2023 CBX3 transcriptionally regulates NCAPG expression in colorectal cancer, as shown by luciferase reporter assay with predicted CBX3 binding sites in the NCAPG promoter; NCAPG activates Wnt/β-catenin signaling to promote CRC cell proliferation and cell cycle progression. Luciferase reporter assay, RT-qPCR, western blot, CCK-8, flow cytometry, TUNEL assay Journal of gastrointestinal oncology Low 37201048
2024 NCAPG interacts with CDK1 and promotes phosphorylation of ERK to drive NSCLC proliferation and metastasis, defining an NCAPG/CDK1/ERK signaling axis. Co-immunoprecipitation, western blot for p-ERK, siRNA knockdown, overexpression, in vitro and in vivo functional assays American journal of cancer research Medium 39659935
2024 In bovine myoblasts, the transcription factors CREB1 and MYOD1 bind to the core promoter region of NCAPG (-598/+87) and activate its transcription, as demonstrated by EMSA and deletion/mutation luciferase reporter assays. Deletion and site-directed mutation luciferase reporter assays, EMSA (electrophoretic mobility shift assay), overexpression experiments International journal of molecular sciences Medium 38473754
2025 NCAPG promotes ferroptosis resistance in HCC by interacting with NSUN2 at residues 446-460 and inhibiting NSUN2 protein degradation; NSUN2 then stabilizes GPX4 mRNA via m5C modification at the coding sequence, increasing GPX4 expression and conferring ferroptosis resistance. Co-immunoprecipitation, western blot, domain mapping mutagenesis (446aa-460aa), m5C modification assay, mRNA stability assay, in vitro and in vivo ferroptosis assays Cellular signalling Medium 41260238
2025 ASPM promotes transport of NCAPG from the nucleus to the cytoplasm by directly binding to it, and enhances NCAPG deubiquitination mediated by BUB3, increasing NCAPG stability; NCAPG then targets the SRC/STAT3 pathway to elevate PD-L1 expression in gastric cancer. Co-immunoprecipitation, mass spectrometry, molecular docking, CUT&Tag, transcriptome sequencing, cellular and organoid experiments Journal of translational medicine Medium 40898336
2025 NCAPG promotes endometrial cancer progression by affecting LEF1 binding to chromatin (assessed by ATAC-seq and ChIP-qPCR), which activates transcription of SEMA7A; SEMA7A then binds the PI3K regulatory subunit p85 to activate the PI3K-AKT pathway. ATAC-seq, ChIP-qPCR, Co-immunoprecipitation, siRNA knockdown, overexpression, in vitro and in vivo functional assays Journal of Cancer Medium 39744480
2026 Bufalin acts as a molecular glue that degrades NCAPG by coupling it to cathepsin V (CTSV), forming a CTSV-NCAPG complex; this degradation induces G2/M cell cycle arrest and inhibits HCC proliferation through downstream regulation of Cyclin D1 and CDK1. Co-immunoprecipitation, confocal microscopy, siRNA knockdown of CTSV and NCAPG, cell cycle analysis, western blot Drug development research Medium 41586569
1995 Human macrophage Cap G (CAPG, the actin-capping protein, distinct from NCAPG/condensin) caps but does not sever actin filaments; gain-of-function mutations converting residues 84LNTLLGE→84LDDYLGG confer severing activity, and adding a second mutation 124AFHKTS→124GFKHV enhances severing 10-fold, identifying two regions critical for the severing/non-severing distinction within the gelsolin superfamily. In vitro actin severing assay, site-directed mutagenesis The Journal of biological chemistry High 7814409

Source papers

Stage 0 corpus · 66 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 Association, effects and validation of polymorphisms within the NCAPG - LCORL locus located on BTA6 with feed intake, gain, meat and carcass traits in beef cattle. BMC genetics 133 22168586
2009 Dissection of genetic factors modulating fetal growth in cattle indicates a substantial role of the non-SMC condensin I complex, subunit G (NCAPG) gene. Genetics 120 19720859
2009 Cross-breed comparisons identified a critical 591-kb region for bovine carcass weight QTL (CW-2) on chromosome 6 and the Ile-442-Met substitution in NCAPG as a positional candidate. BMC genetics 100 19653884
2013 A genome-wide association study indicates LCORL/NCAPG as a candidate locus for withers height in German Warmblood horses. Animal genetics 97 23418885
2019 NCAPG Promotes The Proliferation Of Hepatocellular Carcinoma Through PI3K/AKT Signaling. OncoTargets and therapy 89 31802891
2011 The SNP c.1326T>G in the non-SMC condensin I complex, subunit G (NCAPG) gene encoding a p.Ile442Met variant is associated with an increase in body frame size at puberty in cattle. Animal genetics 70 22035007
2017 Non-SMC Condensin I Complex, Subunit G (NCAPG) is a Novel Mitotic Gene Required for Hepatocellular Cancer Cell Proliferation and Migration. Oncology research 66 29046167
2018 Regulation of NCAPG by miR-99a-3p (passenger strand) inhibits cancer cell aggressiveness and is involved in CRPC. Cancer medicine 64 29608247
2003 Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress. The Journal of biological chemistry 61 12754261
2018 Dysregulation of NCAPG, KNL1, miR-148a-3p, miR-193b-3p, and miR-1179 may contribute to the progression of gastric cancer. Biological research 57 30390708
2019 Genome-wide CRISPR knockout screens identify NCAPG as an essential oncogene for hepatocellular carcinoma tumor growth. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 56 31022357
2020 NCAPG confers trastuzumab resistance via activating SRC/STAT3 signaling pathway in HER2-positive breast cancer. Cell death & disease 49 32683421
2016 Multi-strategy genome-wide association studies identify the DCAF16-NCAPG region as a susceptibility locus for average daily gain in cattle. Scientific reports 45 27892541
2022 NCAPG promotes the oncogenesis and progression of non-small cell lung cancer cells through upregulating LGALS1 expression. Molecular cancer 40 35180865
2004 The Drosophila melanogaster condensin subunit Cap-G interacts with the centromere-specific histone H3 variant CID. Chromosoma 39 15592865
2022 NCAPG facilitates colorectal cancer cell proliferation, migration, invasion and epithelial-mesenchymal transition by activating the Wnt/β-catenin signaling pathway. Cancer cell international 36 35292013
2020 NCAPG Is a Promising Therapeutic Target Across Different Tumor Types. Frontiers in pharmacology 36 32300299
2013 Comparison of the effects explained by variations in the bovine PLAG1 and NCAPG genes on daily body weight gain, linear skeletal measurements and carcass traits in Japanese Black steers from a progeny testing program. Animal science journal = Nihon chikusan Gakkaiho 36 23607392
2019 MicroRNA‑181c suppresses growth and metastasis of hepatocellular carcinoma by modulating NCAPG. Cancer management and research 35 31114379
2008 Phosphorylation of CAP-G is required for its chromosomal DNA localization during mitosis. Biochemical and biophysical research communications 31 18977199
2015 Systems biology analysis merging phenotype, metabolomic and genomic data identifies Non-SMC Condensin I Complex, Subunit G (NCAPG) and cellular maintenance processes as major contributors to genetic variability in bovine feed efficiency. PloS one 30 25875852
2013 Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I. PLoS genetics 30 23637630
2021 NCAPG promotes the progression of lung adenocarcinoma via the TGF-β signaling pathway. Cancer cell international 29 34419073
2022 The role of NCAPG in various of tumors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 28 36095957
2015 NCAPG is differentially expressed during longissimus muscle development and is associated with growth traits in Chinese Qinchuan beef cattle. Genetics and molecular biology 26 26692155
1995 Gain-of-function mutations conferring actin-severing activity to human macrophage cap G. The Journal of biological chemistry 26 7814409
2016 Skeletal variation in Tennessee Walking Horses maps to the LCORL/NCAPG gene region. Physiological genomics 25 26931356
2020 Overexpression of NCAPG inhibits cardia adenocarcinoma apoptosis and promotes epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway. Gene 21 32980450
2020 NCAPG Induces Cell Proliferation in Cardia Adenocarcinoma via PI3K/AKT Signaling Pathway. OncoTargets and therapy 20 33177839
1994 The human actin-regulatory protein cap G: gene structure and chromosome location. Genomics 18 7851883
2020 NCAPG Dynamically Coordinates the Myogenesis of Fetal Bovine Tissue by Adjusting Chromatin Accessibility. International journal of molecular sciences 16 32070024
2016 Levels of Ycg1 Limit Condensin Function during the Cell Cycle. PLoS genetics 16 27463097
2024 Defining a Haplotype Encompassing the LCORL-NCAPG Locus Associated with Increased Lean Growth in Beef Cattle. Genes 14 38790206
2022 NCAPG promotes the proliferation of hepatocellular carcinoma through the CKII-dependent regulation of PTEN. Journal of translational medicine 14 35864529
2021 NCAPG, mediated by miR-378a-3p, regulates cell proliferation, cell cycle progression, and apoptosis of oral squamous cell carcinoma through the GSK-3β/β-catenin signaling. Neoplasma 13 34585587
2021 Inhibition of NCAPG expression inactivates the Wnt/β-catenin signal to suppresses endometrial cancer cell growth in vitro. Environmental toxicology 12 34480403
2023 NCAPG is transcriptionally regulated by CBX3 and activates the Wnt/β-catenin signaling pathway to promote proliferation and the cell cycle and inhibit apoptosis in colorectal cancer. Journal of gastrointestinal oncology 11 37201048
2022 Overexpression of NCAPG in ovarian cancer is associated with ovarian cancer proliferation and apoptosis via p38 MAPK signaling pathway. Journal of ovarian research 11 35986371
2022 NCAPG Promotes Tumor Progression and Modulates Immune Cell Infiltration in Glioma. Frontiers in oncology 10 35372056
2017 Transcription of a B chromosome CAP-G pseudogene does not influence normal Condensin Complex genes in a grasshopper. Scientific reports 9 29247237
2022 NCAPG promotes tumorigenesis of bladder cancer through NF-κB signaling pathway. Biochemical and biophysical research communications 8 35843088
2022 Characterizing the Crosstalk of NCAPG with Tumor Microenvironment and Tumor Stemness in Stomach Adenocarcinoma. Stem cells international 8 36238529
2022 NCAPG deregulation indicates poor patient survival and contributes to colorectal carcinogenesis. Pathology, research and practice 8 36442414
2025 CAFs promote immune evasion in gastric cancer through histone lactylation-mediated suppression of NCAPG ubiquitination. Journal of translational medicine 6 40898336
2023 NCAPG stimulates lung adenocarcinoma cell stemness through aerobic glycolysis. The clinical respiratory journal 6 37553792
2022 NCAPG Promotes the Proliferation of Renal Clear Cell Carcinoma via Mediating with CDK1. Disease markers 6 35601741
2019 Solution structure and flexibility of the condensin HEAT-repeat subunit Ycg1. The Journal of biological chemistry 6 31350339
2025 CircRNA circACTN4 Promotes the Progression of Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma by Targeting the miR-424-5p/NCAPG/Wnt Axis. Clinical and experimental medicine 5 39891781
2023 E2F1-mediated Up-regulation of NCAPG Promotes Hepatocellular Carcinoma Development by Inhibiting Pyroptosis. Journal of clinical and translational hepatology 5 38250463
2012 Polymorphism of the FAM13A, ABCG2, OPN, LAP3, HCAP-G, PPARGC1A genes and somatic cell count of Jersey cows--preliminary study. Research in veterinary science 5 23021125
2024 Reduced miR-99a-3p levels in systemic lupus erythematosus may promote B cell proliferation via NCAPG and the PI3K/AKT signaling pathway. Lupus 4 38320572
2023 Knockdown of NCAPG promotes the apoptosis and inhibits the invasion and migration of triple‑negative breast cancer MDA‑MB‑231 cells via regulation of EGFR/JAK/STAT3 signaling. Experimental and therapeutic medicine 4 36815969
2023 Identification of NCAPG as an Essential Gene for Neuroblastoma Employing CRISPR-Cas9 Screening Database and Experimental Verification. International journal of molecular sciences 4 37834394
2023 NCAPG Regulates Myogenesis in Sheep, and SNPs Located in Its Putative Promoter Region Are Associated with Growth and Development Traits. Animals : an open access journal from MDPI 4 37893897
2024 Unlocking the Transcriptional Control of NCAPG in Bovine Myoblasts: CREB1 and MYOD1 as Key Players. International journal of molecular sciences 3 38473754
2025 NCAPG promotes the malignant progression of endometrioid cancer through LEF1/SEMA7A/PI3K-AKT. Journal of Cancer 2 39744480
2025 Characterizing differences in the muscle transcriptome between cattle with alternative LCORL-NCAPG haplotypes. BMC genomics 2 40369436
2024 Up-regulation of NCAPG mediated by E2F1 facilitates the progression of osteosarcoma through the Wnt/β-catenin signaling pathway. Translational cancer research 2 38881929
2024 Association of SPP1 and NCAPG genes with milk production traits in Chinese Holstein cows: polymorphism and functional validation analysis. Frontiers in veterinary science 2 39545257
2024 NCAPG-mediated CDK1 promotes malignant progression of non-small cell lung cancer via ERK signaling activation. American journal of cancer research 2 39659935
2025 In smokers, the axis NCAPG/hsa-let-7b-5p/TMPO-AS1 promotes lung adenocarcinoma. Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology 1 40242419
2023 The Diagnostic and Therapeutic Value of NCAPG as a Proposed Biomarker Candidate in Acute Liver Failure. Combinatorial chemistry & high throughput screening 1 37066775
2026 Discovery of Bufalin as a Molecular Glue Degrader of NCAPG to Inhibit the Proliferation of Hepatoma Cells. Drug development research 0 41586569
2026 Impact of Mutations in the NCAPG and MSTN Genes on Body Composition, Structural Properties of Skeletal Muscle, Its Fatty Acid Composition, and Meat Quality of Bulls from a Charolais × Holstein F2 Cross. International journal of molecular sciences 0 41596529
2025 Polymorphism of NCAPG gene and its association with growth traits in Nanjiang Yellow goat. Animal biotechnology 0 41056441
2025 NCAPG confers ferroptosis resistance of hepatocellular carcinoma through NSUN2-mediated m5C modification. Cellular signalling 0 41260238