Affinage

NCAPG

Condensin complex subunit 3 · UniProt Q9BPX3

Length
1015 aa
Mass
114.3 kDa
Annotated
2026-06-10
66 papers in source corpus 27 papers cited in narrative 27 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NCAPG encodes the Cap-G subunit of the condensin I complex, a chromosome-condensation machine required for faithful sister chromatid segregation during mitosis (PMID:15592865, PMID:23637630). As a HEAT-repeat subunit, NCAPG/Ycg1 is conformationally flexible in isolation and rigidifies upon binding its kleisin partner, and it is the limiting, cell-cycle-regulated component for assembly of intact condensin: its levels peak in mitosis and decline in G1 through regulated transcription and constitutive degradation, and forcing its accumulation drives premature condensin assembly and proliferation defects (PMID:27463097, PMID:31350339). Its chromosomal localization is governed by cdc2/cyclin B phosphorylation at Thr308 and Thr332, and it engages centromeric CENP-A/CID to couple condensin to kinetochore-dependent chromatid segregation (PMID:18977199, PMID:15592865). Loss of NCAPG produces aberrant mitosis, mitotic arrest, and cell death, and genome-wide CRISPR screens rank it among the most essential genes for hepatocellular carcinoma growth (PMID:31022357, PMID:29046167). Beyond its mitotic role, NCAPG functions as an oncogenic driver across multiple tumor types, acting upstream of a broad set of growth and survival pathways: it activates PI3K/AKT signaling—through interaction with casein kinase II to suppress PTEN and via a LEF1/SEMA7A axis (PMID:35864529, PMID:39744480)—drives SRC/STAT3 signaling to promote therapy resistance and immune evasion (PMID:32683421, PMID:40898336), interacts directly with β-catenin to engage Wnt/β-catenin signaling (PMID:35292013), and promotes TGF-β/Smad signaling (PMID:34419073). It additionally stabilizes the m5C methyltransferase NSUN2 to confer ferroptosis resistance via GPX4 (PMID:41260238) and shapes chromatin accessibility at AP-1 sites during myoblast differentiation (PMID:32070024). NCAPG transcription is driven by E2F1, CREB1, and MYOD1 (PMID:38250463, PMID:38473754), and it can be selectively degraded by the molecular glue bufalin through coupling to cathepsin V (PMID:41586569). Note that several early-numbered findings describe the gelsolin-family actin-capping protein CAPG, a distinct protein sharing the CAPG alias, not the condensin subunit (PMID:7814409, PMID:7851883, PMID:12754261).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2004 Medium

    Established that the condensin Cap-G subunit physically links the complex to the centromere and is required for chromatid segregation, defining its core mitotic role.

    Evidence Genetic modifier screen and yeast two-hybrid in Drosophila, with analysis of Cap-G mutant embryo mitosis

    PMID:15592865

    Open questions at the time
    • Interaction mapped in Drosophila CID, not human CENP-A directly
    • Structural basis of the Cap-G/centromere contact not resolved
  2. 2008 High

    Showed that cdc2/cyclin B phosphorylation of two threonines controls Cap-G chromosomal localization, identifying a cell-cycle kinase input governing condensin targeting.

    Evidence Site-directed mutagenesis (T308A/T332A), in vitro kinase assay, mitotic immunofluorescence

    PMID:18977199

    Open questions at the time
    • Functional consequence for condensation/segregation beyond localization not quantified
    • Phospho-site occupancy in vivo not measured
  3. 2013 High

    Resolved which condensin Cap-G associates with, showing exclusive incorporation into condensin I and that interphase nuclear enrichment is dispensable for function.

    Evidence Co-IP, mass spectrometry, live EGFP imaging, in vitro complex formation in Drosophila

    PMID:23637630

    Open questions at the time
    • Does not address human condensin I/II partition directly
    • Function of nuclear enrichment, if any, undefined
  4. 2016 High

    Identified Cap-G/Ycg1 as the rate-limiting subunit for condensin assembly under cell-cycle control, explaining how condensin abundance is gated to mitosis.

    Evidence Cell-cycle synchronization, Western blot, ChIP, overexpression and stabilizing mutants in budding yeast

    PMID:27463097

    Open questions at the time
    • Limiting-subunit role demonstrated in yeast, not confirmed in human cells
    • Degradation machinery not identified
  5. 2019 High

    Defined the conformational behavior of the subunit, showing it is flexible alone and rigidified by its kleisin partner, providing a structural basis for assembly-dependent activation.

    Evidence SAXS, multiangle light scattering, normal mode analysis of Ycg1 free and Brn1-bound

    PMID:31350339

    Open questions at the time
    • No high-resolution structure of the human subunit
    • Functional consequence of free-subunit oligomerization unknown
  6. 2019 High

    Demonstrated NCAPG is essential for cancer cell proliferation and mitotic fidelity, elevating it from a structural subunit to a tumor dependency.

    Evidence Genome-wide CRISPR dropout screen, siRNA, xenograft, mitochondrial imaging in HCC; PI3K/AKT/FOXO4 rescue with inhibitor/activator

    PMID:29046167 PMID:31022357 PMID:31802891

    Open questions at the time
    • Link between mitotic defect and mitochondrial network fragmentation mechanistically unresolved
    • Whether oncogenic dependency reflects condensin function or a moonlighting role unclear
  7. 2022 Medium

    Mapped direct protein interactions through which NCAPG activates growth signaling, moving beyond correlation to physical mechanism.

    Evidence IP-MS and Co-IP identifying CKII (PTEN/PI3K-AKT) and β-catenin (Wnt) interactions in HCC and CRC

    PMID:35292013 PMID:35864529

    Open questions at the time
    • Interaction interfaces not mapped for CKII or β-catenin
    • Whether interactions require condensin assembly not tested
  8. 2022 Medium

    Showed an in vivo genetic requirement for NCAPG in tumorigenesis, strengthening the causal link beyond cell-line knockdown.

    Evidence Ncapg+/- mouse with urethane carcinogenesis, transcriptome sequencing, LGALS1 link

    PMID:35180865

    Open questions at the time
    • Direct NCAPG-LGALS1 interaction not fully confirmed
    • Tissue-specific conditional knockout not performed
  9. 2024 Medium

    Established the transcriptional inputs driving NCAPG expression, identifying the upstream regulators that elevate it in proliferative and oncogenic states.

    Evidence ChIP/luciferase for E2F1 in HCC; EMSA, deletion reporter and mutagenesis for CREB1/MYOD1 in bovine cells

    PMID:38250463 PMID:38473754

    Open questions at the time
    • Combinatorial regulation among E2F1/CREB1/MYOD1 not dissected
    • CBX3 regulation (idx 18) rests on reporter without ChIP
  10. 2025 Medium

    Extended NCAPG mechanism into protein-stability and RNA-modification control, linking it to immune evasion and ferroptosis resistance.

    Evidence Co-IP/MS with ASPM (deubiquitination, SRC/STAT3, PD-L1) and domain-mapped NSUN2 interaction (m5C-GPX4) in gastric cancer and HCC

    PMID:40898336 PMID:41260238

    Open questions at the time
    • NSUN2 interaction domain mapped but structural validation absent
    • Whether these roles are independent of condensin function untested
  11. 2026 Medium

    Demonstrated NCAPG can be pharmacologically targeted via induced degradation, establishing therapeutic tractability.

    Evidence Co-IP, confocal, CTSV/NCAPG siRNA, cell-cycle and proliferation assays showing bufalin-induced CTSV-NCAPG complex in HCC

    PMID:41586569

    Open questions at the time
    • Direct molecular-glue ternary structure not resolved
    • Selectivity over other condensin subunits not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved whether NCAPG's many oncogenic signaling interactions (CKII, β-catenin, SRC/STAT3, NSUN2, CDK1) depend on its condensin role or reflect a distinct cytoplasmic moonlighting function, and whether its mitotic phosphoregulation intersects with these pathways.
  • No study reconciles condensin assembly state with signaling interactions
  • Subcellular pool driving oncogenic signaling not defined
  • Human structural data on NCAPG lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 5 GO:0005198 structural molecule activity 2
Localization
GO:0005634 nucleus 2 GO:0005694 chromosome 2 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-1640170 Cell Cycle 5 R-HSA-4839726 Chromatin organization 2
Partners
ASPMCDK1CENP-A/CIDCSNK2/CKIICTNNB1CTSVNCAPH/BRN1NSUN2
Complex memberships
condensin I

Evidence

Reading pass · 27 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 CAP-G (NCAPG) contains two threonine residues (Thr308 and Thr332) that are phosphorylated by cdc2/cyclin B. Mutation of these threonines to alanines results in defects in CAP-G localization with chromosomal DNA during mitosis, establishing phosphorylation as a regulator of condensin chromosomal localization. Site-directed mutagenesis (T308A, T332A), in vitro cdc2/cyclin B kinase assay, immunofluorescence localization during mitosis Biochemical and biophysical research communications High 18977199
2004 Drosophila condensin subunit Cap-G (ortholog of NCAPG) physically interacts with the centromere-specific histone H3 variant CID (CENP-A homolog), as shown by yeast two-hybrid. Loss-of-function Cap-G mutant embryos show massive sister chromatid segregation defects during mitosis, linking condensin to kinetochore structure and chromatid segregation. Genetic modifier screen (rough eye phenotype), yeast two-hybrid interaction assay, analysis of Cap-G mutant embryo mitosis Chromosoma Medium 15592865
2013 Drosophila Cap-G associates exclusively with condensin I and not condensin II. In vivo, Cap-G-EGFP shows nuclear enrichment during interphase, but this nuclear localization is dispensable for chromatin association, condensin I complex assembly, and animal viability. Mass spectrometry of condensin II-specific subunit Cap-H2 immunoprecipitates failed to detect Cap-G. Immunoprecipitation, in vivo EGFP fusion microscopy, mass spectrometry, in vitro complex formation assays PLoS genetics High 23637630
2016 In budding yeast, Ycg1 (Cap-G/NCAPG ortholog) is cell-cycle regulated with protein levels peaking in mitosis and decreasing in G1, controlled by cell-cycle-regulated transcription and constitutive degradation. Ycg1 is limiting for condensin complex formation: overexpression of Ycg1 (but not other condensin subunits) increases intact condensin complex levels and chromatin binding in G1, causing delayed cell-cycle entry and proliferation defects. Cell cycle synchronization, Western blotting, chromatin immunoprecipitation (ChIP), overexpression and stabilizing mutation analysis in S. cerevisiae PLoS genetics High 27463097
2019 Solution SAXS characterization of the condensin HEAT-repeat subunit Ycg1 (Cap-G/NCAPG ortholog) reveals it is flexible in solution as a free subunit but becomes considerably more rigid upon binding its kleisin partner Brn1. Free Ycg1 tends to oligomerize at higher concentrations in the absence of Brn1. Small-angle X-ray scattering (SAXS), dynamic and static multiangle light scattering, normal mode analysis structural modeling The Journal of biological chemistry High 31350339
1995 Human macrophage Cap G (CAPG/NCAPG alias) caps but does not sever actin filaments. Gain-of-function mutations converting residues 84LNTLLGE to the gelsolin actin-binding helix sequence (84LDDYLGG) conferred actin-severing activity; adding a second mutation converting 124AFHKTS to 124GFKHV enhanced severing 10-fold. These two regions are critical determinants of the lack of severing activity in wild-type Cap G. Site-directed mutagenesis, in vitro actin filament severing assay The Journal of biological chemistry High 7814409
1994 The human Cap G gene (CAPG, an alias for NCAPG in the gelsolin-family context) is 16.6 kb, contains 10 exons and 9 introns, and maps to chromosome 2p. Comparison of splice sites with gelsolin and villin indicates CAPG is more closely related to gelsolin. Genomic cloning, sequencing, chromosomal mapping, comparative gene structure analysis Genomics Medium 7851883
2003 Cap G (gelsolin-family macrophage capping protein) protein and mRNA are upregulated ~2-fold and ~5-fold, respectively, in endothelial cells exposed to atheroprotective (plaque-free) unidirectional shear stress compared to static culture; this increase is absent under plaque-prone flow. The increase occurs in nuclear and cytoskeletal-associated fractions. Overexpression of Cap G in transfection assays increased endothelial cell motility. 2D gel proteomics, quantitative RT-PCR, subcellular fractionation, transfection overexpression motility assay The Journal of biological chemistry Medium 12754261
2019 NCAPG (condensin I subunit) knockdown in HCC cells causes aberrant mitotic division, fragmentation of the mitochondrial network, and increased cell death in vitro; genome-wide CRISPR dropout screens ranked NCAPG as the highest essential gene for HCC growth. Small interfering RNA knockdown reduced cell growth, migration, and downregulated mitochondrial gene expression. Genome-wide CRISPR knockout dropout screen, siRNA knockdown, xenograft tumor model, mitochondrial network imaging FASEB journal High 31022357
2017 NCAPG knockdown induces mitotic defects and inhibits HCC cell growth, proliferation, and migration in vitro; tetracycline-inducible shRNA knockdown inhibits tumor growth in vivo. NCAPG overexpression is correlated with overexpression of CCNB1 (cyclin B1), a mitotic regulatory protein. siRNA and inducible shRNA knockdown, cell proliferation assay, wound-healing migration assay, xenograft tumor model, expression correlation analysis Oncology research Medium 29046167
2019 NCAPG overexpression activates the PI3K/AKT/FOXO4 pathway and alters expression of apoptosis-related proteins in HCC cells. The PI3K inhibitor LY294002 abolished NCAPG-mediated promotion of proliferation and reduction of apoptosis, while the PI3K activator 740Y-P had the opposite effect, placing NCAPG upstream of PI3K/AKT/FOXO4 in HCC proliferation signaling. siRNA knockdown and plasmid overexpression, EdU proliferation assay, flow cytometry apoptosis, RNA-seq pathway analysis, PI3K inhibitor/activator rescue experiments, Western blotting, xenograft model OncoTargets and therapy Medium 31802891
2020 NCAPG overexpression in HER2-positive breast cancer cells promotes trastuzumab resistance by phosphorylating SRC and enhancing nuclear localization and transcriptional activation of STAT3, establishing NCAPG as an upstream activator of the SRC/STAT3 signaling pathway. Overexpression and siRNA knockdown, Western blotting for phospho-SRC and nuclear STAT3, cell proliferation/apoptosis assays, in vivo xenograft, immunofluorescence for STAT3 nuclear localization Cell death & disease Medium 32683421
2022 NCAPG physically interacts with β-catenin in colorectal cancer cells, activating the Wnt/β-catenin signaling pathway to promote EMT, proliferation, migration, and invasion. Co-immunoprecipitation (Co-IP), immunofluorescence, Western blotting, siRNA knockdown and overexpression Cancer cell international Medium 35292013
2022 NCAPG promotes HCC proliferation by interacting with CKII (casein kinase II). Their interaction was identified by IP-mass spectrometry and confirmed by Co-IP. NCAPG-CKII interaction promotes PTEN phosphorylation, thereby inhibiting PTEN transcription and function and activating the PI3K/AKT pathway. IP-mass spectrometry, Co-immunoprecipitation, transcriptome sequencing, EdU and CCK-8 proliferation assays, FISH, xenograft model Journal of translational medicine Medium 35864529
2020 NCAPG silencing in fetal bovine myoblasts prolongs mitosis and impairs differentiation through increased apoptosis. ATAC-seq revealed that NCAPG knockdown alters chromatin accessibility at AP-1 (activating protein 1) binding sites, and knockdown of AP-1 subunits FOSL2 or JUNB partially phenocopied the effect on muscle-specific gene expression. siRNA knockdown, ATAC-seq, immunofluorescence, gene expression quantification, AP-1 subunit knockdown International journal of molecular sciences Medium 32070024
2021 NCAPG overexpression in lung adenocarcinoma increases phospho-Smad2 and phospho-Smad3 in the TGF-β signaling pathway. Rescue experiments showed that TGF-β pathway inhibitors restored the effect of NCAPG overexpression, placing NCAPG upstream of TGF-β/Smad signaling in LUAD. siRNA knockdown and overexpression, Western blotting for p-Smad2/p-Smad3, TGF-β inhibitor rescue, in vitro and in vivo functional assays Cancer cell international Medium 34419073
2022 NCAPG promotes NSCLC progression via the NCAPG/CDK1/ERK axis: NCAPG interacts with CDK1, and this interaction promotes phosphorylation of ERK, driving cell growth and metastasis in vitro and in vivo. Co-immunoprecipitation, Western blotting for phospho-ERK, siRNA knockdown, xenograft model American journal of cancer research Low 39659935
2023 E2F1 transcription factor directly binds the NCAPG promoter and transactivates NCAPG expression in HCC. E2F1 binding was confirmed by ChIP and luciferase reporter assay; HBx transfection co-upregulated both E2F1 and NCAPG. NCAPG knockdown promotes NLRP3 inflammasome-mediated pyroptosis in HCC cells. Dual luciferase reporter assay, chromatin immunoprecipitation (ChIP), Western blotting, scanning electron microscopy for pyroptosis, siRNA knockdown, xenograft model Journal of clinical and translational hepatology Medium 38250463
2023 CBX3 transcriptionally regulates NCAPG expression in colorectal cancer, as demonstrated by predicted CBX3 binding sites in the NCAPG promoter and luciferase reporter assay confirming promoter activity. CBX3-mediated NCAPG expression activates Wnt/β-catenin signaling to regulate CRC cell proliferation, cell cycle, and apoptosis. Luciferase reporter assay, RT-qPCR, Western blot, CCK-8, flow cytometry, TUNEL assay, caspase activity assay Journal of gastrointestinal oncology Low 37201048
2024 CREB1 and MYOD1 bind to the core promoter region (-598/+87) of bovine NCAPG and activate its transcription, as established by deletion reporter assays, site-directed mutagenesis of binding sites, overexpression experiments, and electrophoretic mobility shift assay (EMSA). Deletion fragment dual-luciferase reporter assay, site-directed mutagenesis, overexpression, EMSA International journal of molecular sciences Medium 38473754
2025 ASPM directly binds NCAPG and promotes its transport from the nucleus to the cytoplasm in gastric cancer cells. ASPM also enhances deubiquitination of NCAPG mediated by BUB3, increasing NCAPG protein levels. Elevated NCAPG then activates the SRC/STAT3 pathway and elevates PD-L1 expression, contributing to immune evasion. Co-immunoprecipitation, mass spectrometry, molecular docking, CUT&Tag, transcriptome sequencing, subcellular fractionation/localization, organoid and in vivo experiments Journal of translational medicine Medium 40898336
2025 NCAPG promotes EC (endometrial cancer) progression by affecting LEF1 binding to chromatin, thereby activating transcription of SEMA7A. SEMA7A then binds the PI3K regulatory subunit p85 to activate PI3K-AKT signaling, establishing the NCAPG/LEF1/SEMA7A/PI3K-AKT axis. ATAC-seq, chromatin immunoprecipitation-qPCR (ChIP-qPCR), Co-immunoprecipitation, functional in vitro and in vivo assays Journal of Cancer Medium 39744480
2025 NCAPG promotes ferroptosis resistance in HCC by interacting with NSUN2 at its 446aa–460aa region, inhibiting NSUN2 protein degradation. NSUN2 then promotes m5C modification of GPX4 mRNA at its coding sequence, stabilizing GPX4 mRNA and increasing GPX4 expression to confer ferroptosis resistance. Co-immunoprecipitation, domain-mapping of NCAPG-NSUN2 interaction, m5C modification assay, GPX4 mRNA stability assay, NSUN2 knockdown rescue, in vivo and in vitro ferroptosis assays Cellular signalling Medium 41260238
2026 Bufalin acts as a molecular glue that specifically degrades NCAPG by coupling it to cathepsin V (CTSV), forming a CTSV-NCAPG complex. This degradation induces G2/M cell cycle arrest and inhibits HCC cell proliferation without triggering apoptosis. Downstream proliferation regulators Cyclin D1 and CDK1 are regulated by bufalin in a CTSV/NCAPG-dependent manner. Co-immunoprecipitation, confocal microscopy, siRNA knockdown of CTSV and NCAPG, cell cycle analysis, CCK-8 proliferation assay, Western blotting Drug development research Medium 41586569
2022 NCAPG knockdown in bladder cancer cells inhibits proliferation through suppression of the NF-κB signaling pathway, as demonstrated by RNA-seq identifying NF-κB as a downstream pathway and verified by luciferase reporter assay and Western blotting. RNA-seq, NF-κB luciferase reporter assay, Western blotting, siRNA knockdown, xenograft model, soft agar assay Biochemical and biophysical research communications Low 35843088
2023 NCAPG knockdown in neuroblastoma activates p53-mediated apoptosis and induces G2/S cell cycle arrest, establishing NCAPG as a suppressor of p53-dependent apoptotic signaling. siRNA knockdown, flow cytometry cell cycle analysis, apoptosis assay, Western blotting for p53 pathway proteins International journal of molecular sciences Low 37834394
2022 NCAPG promotes lung cancer oncogenesis through upregulation of LGALS1 (Galectin-1), and LGALS1 may interact directly with NCAPG. Ncapg+/- mice showed reduced urethane-induced lung tumor formation compared to wild-type, demonstrating an in vivo requirement for NCAPG in lung tumorigenesis. Transcriptome sequencing, Ncapg heterozygous mouse model with urethane carcinogenesis, siRNA knockdown, in vivo xenograft, IHC Molecular cancer Medium 35180865

Source papers

Stage 0 corpus · 66 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 Association, effects and validation of polymorphisms within the NCAPG - LCORL locus located on BTA6 with feed intake, gain, meat and carcass traits in beef cattle. BMC genetics 134 22168586
2009 Dissection of genetic factors modulating fetal growth in cattle indicates a substantial role of the non-SMC condensin I complex, subunit G (NCAPG) gene. Genetics 120 19720859
2009 Cross-breed comparisons identified a critical 591-kb region for bovine carcass weight QTL (CW-2) on chromosome 6 and the Ile-442-Met substitution in NCAPG as a positional candidate. BMC genetics 100 19653884
2013 A genome-wide association study indicates LCORL/NCAPG as a candidate locus for withers height in German Warmblood horses. Animal genetics 97 23418885
2019 NCAPG Promotes The Proliferation Of Hepatocellular Carcinoma Through PI3K/AKT Signaling. OncoTargets and therapy 89 31802891
2011 The SNP c.1326T>G in the non-SMC condensin I complex, subunit G (NCAPG) gene encoding a p.Ile442Met variant is associated with an increase in body frame size at puberty in cattle. Animal genetics 70 22035007
2017 Non-SMC Condensin I Complex, Subunit G (NCAPG) is a Novel Mitotic Gene Required for Hepatocellular Cancer Cell Proliferation and Migration. Oncology research 67 29046167
2018 Regulation of NCAPG by miR-99a-3p (passenger strand) inhibits cancer cell aggressiveness and is involved in CRPC. Cancer medicine 65 29608247
2003 Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress. The Journal of biological chemistry 62 12754261
2019 Genome-wide CRISPR knockout screens identify NCAPG as an essential oncogene for hepatocellular carcinoma tumor growth. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 58 31022357
2018 Dysregulation of NCAPG, KNL1, miR-148a-3p, miR-193b-3p, and miR-1179 may contribute to the progression of gastric cancer. Biological research 57 30390708
2020 NCAPG confers trastuzumab resistance via activating SRC/STAT3 signaling pathway in HER2-positive breast cancer. Cell death & disease 50 32683421
2016 Multi-strategy genome-wide association studies identify the DCAF16-NCAPG region as a susceptibility locus for average daily gain in cattle. Scientific reports 45 27892541
2022 NCAPG promotes the oncogenesis and progression of non-small cell lung cancer cells through upregulating LGALS1 expression. Molecular cancer 41 35180865
2004 The Drosophila melanogaster condensin subunit Cap-G interacts with the centromere-specific histone H3 variant CID. Chromosoma 39 15592865
2020 NCAPG Is a Promising Therapeutic Target Across Different Tumor Types. Frontiers in pharmacology 38 32300299
2022 NCAPG facilitates colorectal cancer cell proliferation, migration, invasion and epithelial-mesenchymal transition by activating the Wnt/β-catenin signaling pathway. Cancer cell international 37 35292013
2013 Comparison of the effects explained by variations in the bovine PLAG1 and NCAPG genes on daily body weight gain, linear skeletal measurements and carcass traits in Japanese Black steers from a progeny testing program. Animal science journal = Nihon chikusan Gakkaiho 36 23607392
2019 MicroRNA‑181c suppresses growth and metastasis of hepatocellular carcinoma by modulating NCAPG. Cancer management and research 35 31114379
2015 Systems biology analysis merging phenotype, metabolomic and genomic data identifies Non-SMC Condensin I Complex, Subunit G (NCAPG) and cellular maintenance processes as major contributors to genetic variability in bovine feed efficiency. PloS one 31 25875852
2008 Phosphorylation of CAP-G is required for its chromosomal DNA localization during mitosis. Biochemical and biophysical research communications 31 18977199
2013 Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I. PLoS genetics 30 23637630
2022 The role of NCAPG in various of tumors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 29 36095957
2021 NCAPG promotes the progression of lung adenocarcinoma via the TGF-β signaling pathway. Cancer cell international 29 34419073
2015 NCAPG is differentially expressed during longissimus muscle development and is associated with growth traits in Chinese Qinchuan beef cattle. Genetics and molecular biology 26 26692155
1995 Gain-of-function mutations conferring actin-severing activity to human macrophage cap G. The Journal of biological chemistry 26 7814409
2016 Skeletal variation in Tennessee Walking Horses maps to the LCORL/NCAPG gene region. Physiological genomics 25 26931356
2020 Overexpression of NCAPG inhibits cardia adenocarcinoma apoptosis and promotes epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway. Gene 21 32980450
2020 NCAPG Induces Cell Proliferation in Cardia Adenocarcinoma via PI3K/AKT Signaling Pathway. OncoTargets and therapy 20 33177839
1994 The human actin-regulatory protein cap G: gene structure and chromosome location. Genomics 18 7851883
2020 NCAPG Dynamically Coordinates the Myogenesis of Fetal Bovine Tissue by Adjusting Chromatin Accessibility. International journal of molecular sciences 17 32070024
2016 Levels of Ycg1 Limit Condensin Function during the Cell Cycle. PLoS genetics 16 27463097
2024 Defining a Haplotype Encompassing the LCORL-NCAPG Locus Associated with Increased Lean Growth in Beef Cattle. Genes 14 38790206
2022 NCAPG promotes the proliferation of hepatocellular carcinoma through the CKII-dependent regulation of PTEN. Journal of translational medicine 14 35864529
2021 NCAPG, mediated by miR-378a-3p, regulates cell proliferation, cell cycle progression, and apoptosis of oral squamous cell carcinoma through the GSK-3β/β-catenin signaling. Neoplasma 14 34585587
2021 Inhibition of NCAPG expression inactivates the Wnt/β-catenin signal to suppresses endometrial cancer cell growth in vitro. Environmental toxicology 12 34480403
2023 NCAPG is transcriptionally regulated by CBX3 and activates the Wnt/β-catenin signaling pathway to promote proliferation and the cell cycle and inhibit apoptosis in colorectal cancer. Journal of gastrointestinal oncology 11 37201048
2022 Overexpression of NCAPG in ovarian cancer is associated with ovarian cancer proliferation and apoptosis via p38 MAPK signaling pathway. Journal of ovarian research 11 35986371
2022 NCAPG Promotes Tumor Progression and Modulates Immune Cell Infiltration in Glioma. Frontiers in oncology 10 35372056
2022 Characterizing the Crosstalk of NCAPG with Tumor Microenvironment and Tumor Stemness in Stomach Adenocarcinoma. Stem cells international 9 36238529
2017 Transcription of a B chromosome CAP-G pseudogene does not influence normal Condensin Complex genes in a grasshopper. Scientific reports 9 29247237
2025 CAFs promote immune evasion in gastric cancer through histone lactylation-mediated suppression of NCAPG ubiquitination. Journal of translational medicine 8 40898336
2022 NCAPG promotes tumorigenesis of bladder cancer through NF-κB signaling pathway. Biochemical and biophysical research communications 8 35843088
2022 NCAPG deregulation indicates poor patient survival and contributes to colorectal carcinogenesis. Pathology, research and practice 8 36442414
2023 NCAPG stimulates lung adenocarcinoma cell stemness through aerobic glycolysis. The clinical respiratory journal 6 37553792
2022 NCAPG Promotes the Proliferation of Renal Clear Cell Carcinoma via Mediating with CDK1. Disease markers 6 35601741
2019 Solution structure and flexibility of the condensin HEAT-repeat subunit Ycg1. The Journal of biological chemistry 6 31350339
2025 CircRNA circACTN4 Promotes the Progression of Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma by Targeting the miR-424-5p/NCAPG/Wnt Axis. Clinical and experimental medicine 5 39891781
2023 Knockdown of NCAPG promotes the apoptosis and inhibits the invasion and migration of triple‑negative breast cancer MDA‑MB‑231 cells via regulation of EGFR/JAK/STAT3 signaling. Experimental and therapeutic medicine 5 36815969
2023 E2F1-mediated Up-regulation of NCAPG Promotes Hepatocellular Carcinoma Development by Inhibiting Pyroptosis. Journal of clinical and translational hepatology 5 38250463
2012 Polymorphism of the FAM13A, ABCG2, OPN, LAP3, HCAP-G, PPARGC1A genes and somatic cell count of Jersey cows--preliminary study. Research in veterinary science 5 23021125
2024 Reduced miR-99a-3p levels in systemic lupus erythematosus may promote B cell proliferation via NCAPG and the PI3K/AKT signaling pathway. Lupus 4 38320572
2024 Unlocking the Transcriptional Control of NCAPG in Bovine Myoblasts: CREB1 and MYOD1 as Key Players. International journal of molecular sciences 4 38473754
2023 Identification of NCAPG as an Essential Gene for Neuroblastoma Employing CRISPR-Cas9 Screening Database and Experimental Verification. International journal of molecular sciences 4 37834394
2023 NCAPG Regulates Myogenesis in Sheep, and SNPs Located in Its Putative Promoter Region Are Associated with Growth and Development Traits. Animals : an open access journal from MDPI 4 37893897
2025 NCAPG promotes the malignant progression of endometrioid cancer through LEF1/SEMA7A/PI3K-AKT. Journal of Cancer 3 39744480
2024 Up-regulation of NCAPG mediated by E2F1 facilitates the progression of osteosarcoma through the Wnt/β-catenin signaling pathway. Translational cancer research 3 38881929
2025 Characterizing differences in the muscle transcriptome between cattle with alternative LCORL-NCAPG haplotypes. BMC genomics 2 40369436
2024 Association of SPP1 and NCAPG genes with milk production traits in Chinese Holstein cows: polymorphism and functional validation analysis. Frontiers in veterinary science 2 39545257
2024 NCAPG-mediated CDK1 promotes malignant progression of non-small cell lung cancer via ERK signaling activation. American journal of cancer research 2 39659935
2025 In smokers, the axis NCAPG/hsa-let-7b-5p/TMPO-AS1 promotes lung adenocarcinoma. Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology 1 40242419
2023 The Diagnostic and Therapeutic Value of NCAPG as a Proposed Biomarker Candidate in Acute Liver Failure. Combinatorial chemistry & high throughput screening 1 37066775
2026 Discovery of Bufalin as a Molecular Glue Degrader of NCAPG to Inhibit the Proliferation of Hepatoma Cells. Drug development research 0 41586569
2026 Impact of Mutations in the NCAPG and MSTN Genes on Body Composition, Structural Properties of Skeletal Muscle, Its Fatty Acid Composition, and Meat Quality of Bulls from a Charolais × Holstein F2 Cross. International journal of molecular sciences 0 41596529
2025 Polymorphism of NCAPG gene and its association with growth traits in Nanjiang Yellow goat. Animal biotechnology 0 41056441
2025 NCAPG confers ferroptosis resistance of hepatocellular carcinoma through NSUN2-mediated m5C modification. Cellular signalling 0 41260238

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