Affinage

MTNR1B

Melatonin receptor type 1B · UniProt P49286

Length
362 aa
Mass
40.2 kDa
Annotated
2026-06-10
100 papers in source corpus 16 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MTNR1B encodes melatonin receptor 1B (MT2), a Gi-coupled receptor that transduces melatonin signaling to control insulin secretion, circadian-regulated tissue function, and cell survival across multiple cell types (PMID:19060908, PMID:22286214). In pancreatic beta cells, where MTNR1B is expressed and localized, melatonin engagement of the receptor inhibits glucose-stimulated insulin secretion (PMID:19060908, PMID:19060909) and suppresses insulin gene transcription through a Raf-1/ERK (MAPK) cascade (PMID:29207116). Genetic and functional dissection establishes the receptor as causally linked to type 2 diabetes risk: rare nonsynonymous variants that abolish or reduce melatonin binding and downstream signaling (e.g. L60R, V124I) confer T2D risk (PMID:22286214, PMID:20200315), while the common intronic risk allele rs10830963 (G) acts as an islet eQTL that raises MTNR1B expression (PMID:19060908, PMID:40898610) and is associated with prolonged duration and delayed offset of melatonin secretion (PMID:26868293), together heightening receptor-mediated suppression of insulin output. Beyond the islet, MTNR1B couples to Gαi2 to control diverse effectors: it recruits CSK/SRC to inhibit SRC kinase and suppress β-catenin–driven cancer stemness (PMID:31140197), upregulates YAP to restrain TNF-α/NF-κB signaling (PMID:35342351), and signals through PKA to block caspase-dependent apoptosis (PMID:33525391). MTNR1B is a clock-controlled gene whose promoter is directly bound and activated by the BMAL1/CLOCK complex at an E-box motif, generating circadian rhythmicity of its expression (PMID:25939854). Knockout studies link the receptor to STAT3/VEGFR2/PI3K-AKT–dependent placental angiogenesis (PMID:38960012) and to astrocytic support of hippocampal GABAergic function (PMID:38176947).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2008 High

    Establishing where MTNR1B acts and what it does in glucose homeostasis: it was unknown whether the T2D-associated locus had a direct beta-cell function, and localization plus functional assay showed melatonin-MTNR1B signaling directly inhibits insulin secretion.

    Evidence Immunocytochemistry, RT-PCR localization to beta cells, and in vitro insulin secretion assays in clonal beta cells; risk-allele carriers showed elevated islet expression

    PMID:19060908 PMID:19060909

    Open questions at the time
    • Did not resolve the molecular cause of the eQTL effect
    • Downstream signaling cascade in beta cells not yet defined
  2. 2010 High

    Testing whether coding variants alter receptor function: nonsynonymous mutants were reconstituted in cells, showing L60R abolishes and V124I reduces MT2 signaling, linking receptor activity to metabolic phenotypes.

    Evidence Transfection of mutant MT2 constructs in COS-7 cells with constitutive and melatonin-induced signaling assays plus population genotyping

    PMID:20200315

    Open questions at the time
    • Variants studied are individually rare
    • Mechanistic link to insulin secretion not directly demonstrated for each variant
  3. 2012 High

    Determining whether loss-of-function broadly drives disease risk: large-scale resequencing with four-tier functional characterization showed rare variants abolishing melatonin binding and signaling contribute to T2D risk.

    Evidence Exon resequencing of 40 nonsynonymous variants, melatonin binding and signaling assays in transfected cells, and genetic association

    PMID:22286214

    Open questions at the time
    • Causal pathway from receptor loss to fasting glucose elevation in vivo not reconstituted
    • No structural basis for binding loss provided
  4. 2015 Medium

    Explaining how MTNR1B expression is timed: ChIP and overexpression demonstrated direct BMAL1/CLOCK activation of the MTNR1B promoter via an E-box, defining it as a clock-controlled gene.

    Evidence ChIP of BMAL1 at the hMTNR1B promoter, BMAL1/CLOCK overexpression, and real-time bioluminometry in human myometrial cells

    PMID:25939854

    Open questions at the time
    • Shown in myometrium; islet circadian regulation not directly tested
    • Functional consequence of rhythmic expression not measured
  5. 2016 Medium

    Distinguishing ligand dynamics from receptor sensitivity: physiological profiling showed the rs10830963 G allele prolongs and delays melatonin secretion, indicating the risk acts partly through ligand exposure timing.

    Evidence Controlled in-laboratory melatonin and dim-light melatonin offset measurements with genotype stratification in 58–96 participants

    PMID:26868293

    Open questions at the time
    • Mechanism linking allele to melatonin synthesis offset unresolved
    • Direct effect on insulin secretion not measured in this study
  6. 2017 Medium

    Mapping the beta-cell signaling output: knockdown, overexpression, and inhibitors showed melatonin-MTNR1B suppresses insulin gene transcription through Raf-1/ERK.

    Evidence MTNR1B overexpression and siRNA in MIN6 cells with Raf-1/ERK western blots, insulin mRNA qPCR, and pharmacological inhibitors

    PMID:29207116

    Open questions at the time
    • Link between transcriptional suppression and secretion phenotype not unified
    • G-protein coupling upstream of Raf-1 not defined in this system
  7. 2019 Medium

    Defining a Gαi2-dependent kinase axis: Co-IP and phospho-analysis showed MTNR1B recruits Gαi2 to assemble CSK/SRC and inhibit SRC, suppressing β-catenin and cancer stemness.

    Evidence Reciprocal Co-IP of CSK/SRC, SRC phospho-site western blots, and MTNR1B deletion analysis in chordoma cells

    PMID:31140197

    Open questions at the time
    • Demonstrated in chordoma; generalizability untested
    • Single-lab finding without reciprocal validation in other cell types
  8. 2021 Medium

    Identifying an anti-apoptotic arm: receptor blockade showed MTNR1B-PKA signaling inhibits caspase-dependent apoptosis under hypoxia.

    Evidence 4P-PDOT antagonist treatment, PKA activity measurement, and caspase assays in hypoxic porcine granulosa cells

    PMID:33525391

    Open questions at the time
    • Porcine model only
    • PKA coupling to MTNR1B inferred from antagonist effect, not directly reconstituted
  9. 2022 Medium

    Extending Gαi2 signaling to anabolic regulation: MTNR1B activates Gαi2 to upregulate YAP, raising IκBα and suppressing TNF-α-induced NF-κB.

    Evidence Western blot, immunoprecipitation, pathway and receptor inhibitors, and lentiviral manipulation in human nucleus pulposus cells with a rat IDD model

    PMID:35342351

    Open questions at the time
    • Mechanism of Gαi2-to-YAP coupling not defined
    • Single-lab finding
  10. 2023 Medium

    Revealing a neural role: astrocyte-specific knockout showed MTNR1B supports GABAergic synaptic function and limits anxiety-like behavior.

    Evidence Cre-loxP astrocyte-specific Mtnr1b knockout with behavioral testing, immunofluorescence for GAD67, and RNA-seq in mice

    PMID:38176947

    Open questions at the time
    • Receptor signaling pathway in astrocytes not defined
    • Link from astrocytic MTNR1B to neuronal GABAergic output is correlative
  11. 2024 Medium

    Establishing a developmental angiogenic role: Mtnr1b (not Mtnr1a) knockout impaired placental angiogenesis via reduced STAT3/VEGFR2/PI3K-AKT signaling.

    Evidence Mtnr1b knockout mice with RNA-seq, histochemistry, and phospho-western blots for the STAT3/VEGFR2/PI3K/AKT cascade

    PMID:38960012

    Open questions at the time
    • Direct coupling from receptor to STAT3 phosphorylation not reconstituted
    • Cell-type origin of the signal within placenta unresolved
  12. 2024 Low

    Linking MTNR1B to RNA modification and epithelial homeostasis: inhibitor studies implicated the receptor in melatonin regulation of m6A methylation and ileum stem cell differentiation via METTL3/Wnt.

    Evidence MTNR1B inhibitor treatment in mouse pregnancy and ileum models with m6A profiling, METTL3 inhibition, and Wnt/β-catenin analysis

    PMID:38255808 PMID:39014159

    Open questions at the time
    • Pharmacological blockade only, m6A mechanism not reconstituted
    • METTL3 link is indirect
    • No genetic loss-of-function confirmation
  13. 2025 Low

    Testing the rs10830963 eQTL mechanism in a human isogenic system: CRISPR-edited hiPSC β-like cells showed slightly higher MTNR1B protein and nominally greater melatonin-mediated suppression of insulin secretion in G/G cells.

    Evidence Isogenic CRISPR/Cas9 editing of rs10830963 in hiPSC/hESC, differentiation to β-like cells, MTNR1B western blot, and insulin secretion assays

    PMID:40898610

    Open questions at the time
    • MTNR1B mRNA was undetectable, so mRNA-level eQTL not confirmed
    • Protein and secretion differences were slight/nominal
    • Immature cell model

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the common rs10830963 risk allele mechanistically links elevated islet MTNR1B expression and altered melatonin dynamics to impaired early-phase insulin secretion in vivo remains incompletely resolved.
  • No structural model of melatonin binding loss for risk variants
  • Unified in vivo causal chain from eQTL to fasting glucose not established
  • Tissue-specific G-protein coupling differences not mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 3
Localization
GO:0005886 plasma membrane 2
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-9909396 Circadian clock 1
Partners
BMAL1CLOCKCSKGNAI2SRC

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 MTNR1B (MT2) mRNA is expressed in human pancreatic islets and is primarily localized in beta cells; individuals carrying the risk allele show increased MTNR1B expression in islets, and insulin release from clonal beta cells in response to glucose is inhibited in the presence of melatonin, establishing a direct inhibitory role of melatonin-MTNR1B signaling on beta-cell insulin secretion. Immunocytochemistry, RT-PCR, in vitro insulin secretion assay in clonal beta cells Nature genetics High 19060908
2008 RT-PCR confirmed MT2 (MTNR1B) transcript expression in human pancreatic islets and beta cells, linking melatonin receptor signaling to glucose homeostasis in the islet. RT-PCR in human pancreatic islets and beta cells Nature genetics High 19060909
2012 Large-scale exon resequencing and four-tiered functional investigation of 40 MTNR1B nonsynonymous variants identified 14 rare non-functional mutants; 4 very rare variants showed complete loss of melatonin binding and signaling, establishing that loss-of-function rare variants in MTNR1B (disrupted melatonin binding and downstream signaling) contribute to T2D risk. Exon resequencing, melatonin binding assays, signaling assays (functional characterization in transfected cells), genetic association Nature genetics High 22286214
2010 Functional characterization of MTNR1B nonsynonymous variants (G24E, L60R, V124I) in transfected COS-7 cells showed that L60R completely disrupts MT2 signaling, V124I considerably decreases it, and G24E shows slightly decreased constitutive activity; the G24E variant associates with increased BMI and decreased fasting plasma glucose in population studies. Transfection of COS-7 cells with mutant MT2 constructs, constitutive and melatonin-induced signaling assays, population genotyping Diabetes High 20200315
2017 Melatonin exerts an inhibitory effect on insulin gene transcription via MTNR1B and the downstream Raf-1/ERK (MAPK) signaling pathway in MIN6 beta cells; MTNR1B knockdown abrogated melatonin-regulated insulin mRNA suppression, and chemical inhibition of Raf-1 or ERK similarly attenuated the effect. MTNR1B overexpression and siRNA knockdown in MIN6 cells, western blot for Raf-1/ERK pathway, insulin mRNA qPCR, pharmacological inhibitors GW5074 and U0126 International journal of molecular medicine Medium 29207116
2022 In human nucleus pulposus cells, melatonin acts via MTNR1B to activate Gαi2 protein, which upregulates YAP levels, leading to anabolic enhancement; melatonin-mediated YAP upregulation increases IκBα expression and suppresses TNF-α-induced NF-κB pathway activation, thereby reversing TNF-α-impaired metabolism of NP cells. Western blotting, immunofluorescence, immunoprecipitation, membrane receptor inhibitors, pathway inhibitors, lentiviral infection, plasmid transfection in human NP cells; rat IDD model with intraperitoneal melatonin International journal of biological sciences Medium 35342351
2019 In chordoma cells, MTNR1B activation by melatonin recruits Gαi2, which inhibits SRC kinase activity by recruiting CSK and SRC together, increasing SRC Y530 phosphorylation and decreasing SRC Y419 phosphorylation; this suppresses β-catenin signaling and cancer cell stemness. MTNR1B loss releases melatonin's repression of β-catenin signaling, promoting cancer stem cell properties and chemoresistance. Co-immunoprecipitation (CSK/SRC complex), phosphorylation analysis of SRC, β-catenin signaling assays, MTNR1B deletion analysis in chordoma tissues, in vitro functional assays Journal of pineal research Medium 31140197
2021 In porcine granulosa cells under hypoxia, blocking MTNR1B with a competitive antagonist (4P-PDOT) diminished melatonin's inhibitory effects on caspase-3 activation; PKA (a downstream kinase of MTNR1B) was confirmed as a mediator of MTNR1B-dependent protection, indicating that melatonin signals through MTNR1B-PKA to inhibit caspase 3/8/9-dependent apoptosis. MTNR1B antagonist (4P-PDOT) treatment, PKA activity measurement, caspase activation assays, antioxidant enzyme expression analysis in hypoxic porcine GCs Antioxidants Medium 33525391
2015 The BMAL1 protein binds to an E-box motif in the proximal promoter of the hMTNR1B gene in human myometrial cells; overexpression of the BMAL1/CLOCK complex activates MTNR1B expression, generating a circadian rhythm in MTNR1B expression in phase with hPER2, establishing MTNR1B as a clock-controlled gene target in human myometrium. Chromatin immunoprecipitation (ChIP) of BMAL1 at hMTNR1B promoter, BMAL1/CLOCK overexpression studies, real-time bioluminometry for circadian rhythms, qPCR Molecular human reproduction Medium 25939854
2024 Mtnr1b knockout (but not Mtnr1a knockout) in mice reduced placental efficiency, increased intrauterine growth restriction, increased placental oxidative stress and apoptosis, and reduced angiogenesis; mechanistically, Mtnr1b knockout reduced STAT3 phosphorylation, which is a promoter of VEGFR2, downregulating VEGFR2 and its downstream PI3K/AKT elements, thereby disrupting placental angiogenesis and development. Mtnr1b knockout mice, RNA sequencing, histochemistry, western blot for STAT3/VEGFR2/PI3K/AKT phosphorylation, vascular density quantification Pharmacological research Medium 38960012
2023 Astrocyte-specific knockout of Mtnr1b (cKO-Gfap mice) caused increased anxiety-like behavior without cognitive impairment; mechanistically, loss of astrocytic Mtnr1b led to downregulation of GAD67 in hippocampal CA1/CA3 areas and reduced GABAA receptor and Kir2.2 expression, indicating MTNR1B in astrocytes supports GABAergic synaptic function. Conditional Cre-loxP astrocyte-specific Mtnr1b knockout, behavioral testing (open field, elevated plus maze, Morris water maze), immunofluorescence for GAD67/vGluT1/NeuN, RNA-seq, qRT-PCR Journal of integrative neuroscience Medium 38176947
2018 siRNA-mediated MTNR1B knockdown in bovine granulosa cells significantly promoted apoptosis (increased BAX, CASP3; decreased BCL2, BCL-XL, SOD1, GPX4) without affecting cell cycle; melatonin's protective effects on apoptosis and cell cycle were largely maintained after MTNR1B knockdown (attributed to compensatory MTNR1A upregulation), except that MTNR1B knockdown abolished melatonin's antioxidant effects on SOD1 and GPX4. RNAi knockdown of MTNR1B in bovine granulosa cells, apoptosis gene expression (qPCR/western blot), cell cycle analysis, MTNR1A expression measurement PeerJ Low 29707428
2024 Melatonin treatment regulates uterine m6A methylation levels via MTNR1B; use of MTNR1B inhibitors reversed melatonin's effects on m6A modification, inflammation, autophagy, and apoptosis pathways, indicating MTNR1B mediates melatonin's regulation of m6A methylation during pregnancy. MTNR1B inhibitor treatment in mouse pregnancy model, m6A methylation profiling, LPS-induced inflammation model, pathway analysis International journal of molecular sciences Low 38255808
2024 Melatonin suppresses ileum inflammation and maintains normal differentiation of ileum stem cells through MTNR1B; MTNR1B inhibitor treatment reversed these effects. The study further showed melatonin-MTNR1B signaling inhibits abnormal METTL3 expression, which would otherwise promote Wnt/β-catenin activity and disrupt cell differentiation. MTNR1B inhibitor treatment, METTL3 inhibitor (SAH), ileum inflammation assays, Wnt/β-catenin pathway analysis, stem cell differentiation assays Inflammation Low 39014159
2016 Carriers of the MTNR1B rs10830963 G risk allele showed a significantly longer duration of elevated melatonin levels (41 min) and delayed circadian phase of dim-light melatonin offset (1.37 h, partially mediated through delayed offset of melatonin synthesis), demonstrating that the risk allele influences the dynamics of melatonin secretion/clearance, not just receptor sensitivity. Intensive in-laboratory protocols measuring melatonin levels and circadian phase (dim-light melatonin offset) in 58–96 participants; actigraphy and polysomnography in cross-sectional studies Diabetes Medium 26868293
2025 In hiPSC-derived β-like cells with isogenic CRISPR/Cas9 edits at rs10830963 (C/C vs G/G), western blot showed slightly higher MTNR1B protein levels in G/G cells consistent with rs10830963 functioning as an eQTL; melatonin addition nominally reduced insulin secretion more efficiently in G-allele carrying cells, suggesting increased receptor-mediated suppression of insulin secretion. CRISPR/Cas9 isogenic editing of hiPSC and hESC at rs10830963, differentiation to β-like cells, western blot for MTNR1B protein, insulin secretion assay with melatonin Journal of pineal research Low 40898610

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Variants in MTNR1B influence fasting glucose levels. Nature genetics 573 19060907
2008 Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nature genetics 562 19060908
2008 A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nature genetics 459 19060909
2012 Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nature genetics 288 22286214
2009 G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans. Diabetes 126 19324940
2007 Melatonin receptor 1B (MTNR1B) gene polymorphism is associated with the occurrence of adolescent idiopathic scoliosis. Spine 116 17632395
2009 Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function. Diabetes 106 19833888
2008 Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function. PloS one 102 19088850
2017 Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study. Clinical nutrition (Edinburgh, Scotland) 93 28455106
2009 A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. Diabetologia 90 19241057
2009 Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians. Diabetes 82 19651812
2016 Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology. Diabetes 76 26868293
2009 Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response. Diabetologia 68 19455304
2010 Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects. PloS one 64 20628598
2022 Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial. Diabetes care 58 35015083
2017 Association Study with 77 SNPs Confirms the Robust Role for the rs10830963/G of MTNR1B Variant and Identifies Two Novel Associations in Gestational Diabetes Mellitus Development. PloS one 58 28072873
2009 Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. Diabetologia 58 19533084
2011 Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 49 21308753
2010 MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai. BMC medical genetics 47 20398260
2016 Interaction between rs10830963 polymorphism in MTNR1B and lifestyle intervention on occurrence of gestational diabetes. Diabetologia 45 27209463
2011 Association study of BMP4, IL6, Leptin, MMP3, and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis. Spine 42 21228692
2010 MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. Diabetes 41 20200315
2013 Association between genetic variations in MTNR1A and MTNR1B genes and gestational diabetes mellitus in Han Chinese women. Gynecologic and obstetric investigation 37 24157813
2010 Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome. Molecular human reproduction 37 20959387
2010 Genetic variants in MTNR1B affecting insulin secretion. Annals of medicine 35 20597807
2019 Associations between chronotype, MTNR1B genotype and risk of type 2 diabetes in UK Biobank. Journal of internal medicine 33 31623012
2012 The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population. Hormones (Athens, Greece) 33 22450346
2017 MTNR1A and MTNR1B gene polymorphisms in women with gestational diabetes. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 31 28084098
2010 Association of a MTNR1B gene variant with fasting glucose and HOMA-B in children and adolescents with high BMI-SDS. European journal of endocrinology 29 21059861
2012 Tired of diabetes genetics? Circadian rhythms and diabetes: the MTNR1B story? Current diabetes reports 28 23015324
2022 Melatonin reverses tumor necrosis factor-alpha-induced metabolic disturbance of human nucleus pulposus cells via MTNR1B/Gαi2/YAP signaling. International journal of biological sciences 27 35342351
2019 The roles of ADIPOQ rs266729 and MTNR1B rs10830963 polymorphisms in patients with gestational diabetes mellitus: A meta-analysis. Gene 27 31884106
2018 Impact of KCNQ1, CDKN2A/2B, CDKAL1, HHEX, MTNR1B, SLC30A8, TCF7L2, and UBE2E2 on risk of developing type 2 diabetes in Thai population. BMC medical genetics 27 29871606
2018 A circadian rhythm-related MTNR1B genetic variant modulates the effect of weight-loss diets on changes in adiposity and body composition: the POUNDS Lost trial. European journal of nutrition 26 29516223
2011 A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: genetic risk is modulated by obesity. Nutrition, metabolism, and cardiovascular diseases : NMCD 26 21558052
2010 Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort. Diabetic medicine : a journal of the British Diabetic Association 26 20536959
2019 MTNR1B genetic polymorphisms as risk factors for gestational diabetes mellitus: a case-control study in a single tertiary care center. Annals of Saudi medicine 25 31580701
2018 Association of melatonin &MTNR1B variants with type 2 diabetes in Gujarat population. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 25 29674279
2015 Gene-Gene Interplay and Gene-Diet Interactions Involving the MTNR1B rs10830963 Variant with Body Weight Loss. Journal of nutrigenetics and nutrigenomics 25 25870980
2014 Genetic variation in MTNR1B is associated with gestational diabetes mellitus and contributes only to the absolute level of beta cell compensation in Mexican Americans. Diabetologia 25 24728128
2021 Melatonin Alleviates Hypoxia-Induced Apoptosis of Granulosa Cells by Reducing ROS and Activating MTNR1B-PKA-Caspase8/9 Pathway. Antioxidants (Basel, Switzerland) 24 33525391
2017 Melatonin exerts an inhibitory effect on insulin gene transcription via MTNR1B and the downstream Raf‑1/ERK signaling pathway. International journal of molecular medicine 23 29207116
2015 A common variant in the MTNR1b gene is associated with increased risk of impaired fasting glucose (IFG) in youth with obesity. Obesity (Silver Spring, Md.) 22 25919927
2015 Circadian clock regulation of melatonin MTNR1B receptor expression in human myometrial smooth muscle cells. Molecular human reproduction 22 25939854
2019 MTNR1B loss promotes chordoma recurrence by abrogating melatonin-mediated β-catenin signaling repression. Journal of pineal research 21 31140197
2011 A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals. Cardiovascular diabetology 21 21470412
2018 The MTNR1B rs10830963 Variant in Interaction with Pre-Pregnancy BMI is a Pharmacogenetic Marker for the Initiation of Antenatal Insulin Therapy in Gestational Diabetes Mellitus. International journal of molecular sciences 20 30477160
2017 Association of the rs10830963 polymorphism in melatonin receptor type 1B (MTNR1B) with metabolic response after weight loss secondary to a hypocaloric diet based in Mediterranean style. Clinical nutrition (Edinburgh, Scotland) 20 28869073
2017 Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go? Current diabetes reports 20 29063374
2006 The role of melatonin receptor 1B gene (MTNR1B) in adolescent idiopathic scoliosis--a genetic association study. Studies in health technology and informatics 19 17108395
2015 MTNR1B gene polymorphisms and susceptibility to Type 2 Diabetes: A pilot study in South Indians. Gene 18 25922310
2014 MTNR1B Genetic Variability Is Associated with Gestational Diabetes in Czech Women. International journal of endocrinology 18 25132852
2020 Maternal MTNR1B genotype, maternal gestational weight gain, and childhood obesity. The American journal of clinical nutrition 17 31826236
2020 Increased Risk of Myocardial Infarction Among Patients With Type 2 Diabetes Who Carry the Common rs10830963 Variant in the MTNR1B Gene. Diabetes care 17 32616615
2011 Association of the rs10830963 polymorphism in MTNR1B with fasting glucose levels in Chinese children and adolescents. Obesity facts 17 21701235
2018 The Circadian Rhythm-Related MTNR1B Genotype, Gestational Weight Gain, and Postpartum Glycemic Changes. The Journal of clinical endocrinology and metabolism 16 29590381
2018 Genome-wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans. Genetic epidemiology 16 29691896
2017 Macronutrient-specific effect of the MTNR1B genotype on lipid levels in response to 2 year weight-loss diets. Journal of lipid research 16 29089366
2015 The Association of rs4753426 Polymorphism in the Melatonin Receptor 1B (MTNR1B) Gene and Susceptibility to Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-analysis. Pain physician 16 26431121
2011 Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents. Pediatric diabetes 16 21366812
2022 The rs10830963 Polymorphism of the MTNR1B Gene: Association With Abnormal Glucose, Insulin and C-peptide Kinetics. Frontiers in endocrinology 15 35733780
2020 A circadian rhythm-related MTNR1B genetic variant (rs10830963) modulate body weight change and insulin resistance after 9 months of a high protein/low carbohydrate vs a standard hypocaloric diet. Journal of diabetes and its complications 15 32057567
2018 Association of Native American ancestry and common variants in ACE, ADIPOR2, MTNR1B, GCK, TCF7L2 and FTO genes with glycemic traits in Colombian population. Gene 15 30063936
2010 Common genetic variation in MTNR1B is associated with serum testosterone, glucose tolerance, and insulin secretion in polycystic ovary syndrome patients. Fertility and sterility 15 20207350
2015 Association between the rs4753426 polymorphism in MTNR1B with fasting plasma glucose level and pancreatic β-cell function in gestational diabetes mellitus. Genetics and molecular research : GMR 14 26345809
2019 Effects of MTNR1B genetic variants on the risk of type 2 diabetes mellitus: A meta-analysis. Molecular genetics & genomic medicine 12 30811895
2011 Association and evolutionary studies of the melatonin receptor 1B gene (MTNR1B) in the self-contained population of Sorbs from Germany. Diabetic medicine : a journal of the British Diabetic Association 12 21711391
2023 Hypomethylation in MTNR1B: a novel epigenetic marker for atherosclerosis profiling using stenosis radiophenotype and blood inflammatory cells. Clinical epigenetics 11 36658621
2020 MTNR1B gene on susceptibility to gestational diabetes mellitus: a two-stage hospital-based study in Southern China. Molecular genetics and genomics : MGG 11 32656703
2022 Interaction between rs10830962 polymorphism in MTNR1B and lifestyle intervention on maternal and neonatal outcomes: secondary analyses of the DALI lifestyle randomized controlled trial. The American journal of clinical nutrition 10 34669935
2010 Analysis of genetic variations in the human melatonin receptor (MTNR1A, MTNR1B) genes and antipsychotics-induced tardive dyskinesia in schizophrenia. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 10 20726823
2019 Association of the rs10830963 polymorphism in MTNR1B with fasting glucose, serum adipokine levels and components of metabolic syndrome in adult obese subjects. Nutricion hospitalaria 9 30834760
2023 Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case-control study. BMC genomics 8 37138267
2019 Dietary-fat effect of the rs10830963 polymorphism in MTNR1B on insulin resistance in response to 3 months weight-loss diets. Endocrinologia, diabetes y nutricion 8 30981681
2015 The polymorphisms of melatonin receptor 1B gene (MTNR1B) (rs4753426 and rs10830963) and susceptibility to adolescent idiopathic scoliosis: a meta-analysis. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 8 25898821
2024 Melatonin Alleviates Lipopolysaccharide-Induced Abnormal Pregnancy through MTNR1B Regulation of m6A. International journal of molecular sciences 7 38255808
2023 MTNR1B gene variations and high pre-pregnancy BMI increase gestational diabetes mellitus risk in Chinese women. Gene 7 38007162
2022 The role of MTNR1B polymorphism on circadian rhythm-related cancer: A UK Biobank cohort study. International journal of cancer 7 35467761
2024 Mtnr1b deletion disrupts placental angiogenesis through the VEGF signaling pathway leading to fetal growth restriction. Pharmacological research 6 38960012
2022 Night Shift Work, MTNR1B rs10830963 Polymorphism, and Prostate Cancer Risk: Findings from a Prospective, Population-Based Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 6 35064058
2020 The effect of SNP rs400827589 in exon 2 of the MTNR1B gene on reproductive seasonality and litter size in sheep. Veterinary medicine and science 6 32378356
2019 Effects of MTNR1B Genetic Variants on Individual Susceptibility to Gestational Diabetes Mellitus: A Meta-Analysis. American journal of perinatology 6 30991439
2018 RNAi-mediated knockdown of MTNR1B without disrupting the effects of melatonin on apoptosis and cell cycle in bovine granulose cells. PeerJ 6 29707428
2015 Increased Insulin following an Oral Glucose Load, Genetic Variation near the Melatonin Receptor MTNR1B, but No Biochemical Evidence of Endothelial Dysfunction in Young Asian Men and Women. PloS one 6 26196519
2023 MTNR1B genotype and effects of carbohydrate quantity and dietary glycaemic index on glycaemic response to an oral glucose load: the OmniCarb trial. Diabetologia 5 38052941
2021 Association between MTNR1B polymorphisms and obesity in African American: findings from the Jackson Heart Study. BMC medical genomics 5 34020621
2021 Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population. Molecular biology reports 5 34117605
2019 MTNR1B Gene Polymorphisms Are Associated With the Therapeutic Responses to Repaglinide in Chinese Patients With Type 2 Diabetes Mellitus. Frontiers in pharmacology 5 31787898
2024 Melatonin via MTNR1B regulates METTL3 to protect ileum cell differentiation. Inflammation 4 39014159
2023 The Association between Dietary Iron Intake, SNP of the MTNR1B rs10830963, and Glucose Metabolism in Chinese Population. Nutrients 4 37111205
2023 Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like Behavior in Adult Male Mice. Journal of integrative neuroscience 4 38176947
2022 No association between a common type 2 diabetes risk gene variant in the melatonin receptor gene (MTNR1B) and mortality among type 2 diabetes patients. Journal of pineal research 4 34967052
2021 Evaluation of the effect of MTNR1B rs10830963 gene variant on the therapeutic efficacy of nateglinide in treating type 2 diabetes among Chinese Han patients. BMC medical genomics 4 34118937
2025 MTNR1B variants increase gestational diabetes mellitus risk in young Chinese pregnant women. Scientific reports 3 40467595
2025 Modeling Genetic Risk of β-Cell Dysfunction in Human Induced Pluripotent Stem Cells From Patients Carrying the MTNR1B Risk Variant. Journal of pineal research 3 40898610
2023 MTNR1A and MTNR1B Gene Variants of the Melatonin Receptor and Arterial Stiffness in Persons without Arterial Hypertension. Bulletin of experimental biology and medicine 3 36892670
2017 Analysis of MTNR1B gene polymorphisms in relationship with IRS2 gene variants, epicardial fat thickness, glucose homeostasis and cognitive performance in the elderly. Chronobiology international 3 28708046
2025 Interaction Between Dietary Fiber Intake and MTNR1B rs10830963 Polymorphism on Glycemic Profiles in Young Brazilian Adults. Genes 2 40428319
2023 Myocardial Infarction Susceptibility and the MTNR1B Polymorphisms. International journal of molecular sciences 2 37511203
2024 [A ssociations of short-term ambient particulate matter exposure and MTNR1B gene with triglyceride-glucose index: A family-based study]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 1 38864120

Missed literature

Know a paper Affinage missed for MTNR1B? Flag it for the maintainers and the community.

No submissions yet.