Affinage

MPP4

MAGUK p55 subfamily member 4 · UniProt Q96JB8

Round 2 corrected
Length
637 aa
Mass
72.8 kDa
Annotated
2026-04-28
77 papers in source corpus 14 papers cited in narrative 14 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MPP4 is a retina-specific MAGUK scaffolding protein that organizes presynaptic protein complexes at rod photoreceptor ribbon synapses, thereby regulating calcium homeostasis and synaptic transmission. It contains PDZ, SH3, guanylate kinase-like (GUK), and L27 domains; the L27 domain mediates heterodimerization with MPP5/PALS1 (recruiting MPP4 into the CRB1 complex at the outer limiting membrane), with PSD95-beta (isoform-specific), and with Veli3, assembling a scaffold that anchors plasma membrane Ca²⁺-ATPases (PMCAs) and the Ca²⁺-dependent chloride channel TMEM16B at the presynaptic membrane (PMID:15914641, PMID:18955048, PMID:19474308). Mpp4-knockout mice lose PMCA, PSD95, and TMEM16B from rod synaptic terminals, develop enlarged synaptic ribbons indicative of elevated presynaptic Ca²⁺, and show compensatory upregulation of SERCA2, establishing MPP4 as essential for presynaptic Ca²⁺ extrusion and ion channel localization (PMID:17341488, PMID:16520334, PMID:19233278). MPP4 expression is controlled by the photoreceptor transcription factor CRX, placing it within the CRX-dependent gene regulatory network for synaptogenesis (PMID:30084954).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2001 Medium

    Identification of MPP4 as a novel retina-enriched MAGUK established that a previously uncharacterized p55-subfamily member might function specifically in photoreceptor biology and could underlie RP26-linked retinopathy.

    Evidence cDNA cloning, EST profiling, RT-PCR, and chromosomal mapping in human retina

    PMID:11414766

    Open questions at the time
    • No pathogenic mutations found in RP26 patients
    • Functional role unknown
    • Protein-level localization not determined
  2. 2003 Medium

    Localization studies resolved where MPP4 acts, placing it at photoreceptor synaptic terminals (outer plexiform layer) and connecting cilia, with rod-specific expression emerging postnatally in mouse — narrowing its function to postnatal synaptic organization rather than photoreceptor development.

    Evidence Immunofluorescence on bovine, porcine, and mouse retinal sections; in situ hybridization; microarray and RT-PCR

    PMID:12859944 PMID:14638699

    Open questions at the time
    • Binding partners at the synapse unknown
    • Discrepancy between species on cone vs. rod expression
    • Functional consequence of synaptic localization not tested
  3. 2005 High

    Biochemical studies answered how MPP4 is integrated into retinal scaffolds: L27-domain-mediated direct interaction with MPP5/PALS1 recruits MPP4 into the CRB1 complex at the OLM, while L27 heterodimerization with Veli3 positions MPP4 as an organizer of a distinct presynaptic complex.

    Evidence Yeast two-hybrid, GST pull-down, co-immunoprecipitation, immunoelectron microscopy, and 3D homology modeling in retina and in vitro

    PMID:15558731 PMID:15914641

    Open questions at the time
    • Whether MPP4's OLM role is functionally important vs. dispensable was untested
    • No loss-of-function data yet
    • Full composition of the presynaptic complex unknown
  4. 2006 High

    Generation of Mpp4-knockout mice demonstrated that MPP4 is essential for anchoring PSD95 and Veli3 at rod presynaptic membranes, while the CRB1 complex at the OLM is unaffected — resolving that MPP4's primary non-redundant function is synaptic, not junctional.

    Evidence Mpp4 knockout mouse: immunohistochemistry, Western blotting, electroretinography, scanning laser ophthalmoscopy

    PMID:16520334

    Open questions at the time
    • Mechanism by which loss of MPP4 destabilizes PSD95 (degradation vs. mistargeting) not resolved
    • Whether synaptic transmission is functionally impaired remained unclear
    • Interaction with DLG1 identified but functional significance unknown
  5. 2007 High

    Analysis of Mpp4-null retinas revealed that MPP4 is required for PMCA localization at rod synapses and that its loss leads to Ca²⁺ dysregulation (enlarged ribbons, compensatory SERCA2 upregulation), establishing MPP4 as a master organizer of presynaptic Ca²⁺ homeostasis.

    Evidence Mpp4 knockout mouse: co-immunoprecipitation, electron microscopy of synaptic ribbons, immunohistochemistry, Western blot, ERG

    PMID:17341488

    Open questions at the time
    • Direct physical interaction between MPP4 and PMCA not demonstrated
    • Quantitative Ca²⁺ measurements not performed
    • Whether cone synapses are affected unresolved
  6. 2008 High

    Unbiased proteomic characterization of the MPP4-associated complex identified PSD95-beta (not alpha) as the specific isoform recruited via L27 domain interaction, along with recoverin and Hsc70, refining the molecular architecture of the presynaptic scaffold.

    Evidence Immunoaffinity chromatography with anti-MPP4 antibody, 2D-PAGE, mass spectrometry, co-IP, and L27 domain mapping from mouse retina

    PMID:18955048

    Open questions at the time
    • Functional roles of recoverin and Hsc70 within the complex unknown
    • Stoichiometry and structural arrangement not determined
  7. 2009 High

    Two studies resolved the functional interdependence within the MPP4 scaffold: TMEM16B (a Ca²⁺-dependent Cl⁻ channel) is lost from photoreceptor membranes in Mpp4-null mice, and isoform-specific rescue with PSD95-beta restores both MPP4 and PMCA1 membrane localization, demonstrating that MPP4 and PSD95-beta cooperatively anchor ion-regulatory proteins at the presynaptic membrane.

    Evidence Mpp4 and Psd95 mutant mice, lentiviral molecular replacement in retinal explants, patch-clamp electrophysiology, immunofluorescence, Western blotting

    PMID:19233278 PMID:19474308

    Open questions at the time
    • Whether TMEM16B directly binds MPP4 or is recruited indirectly unknown
    • In vivo electrophysiological consequences for visual function not fully characterized
  8. 2018 Medium

    Identification of CRX as a transcriptional regulator of MPP4 placed the gene within the photoreceptor-specific gene regulatory network governing synaptogenesis, linking upstream transcription factor control to presynaptic scaffold assembly.

    Evidence Immunohistochemistry in Crx-null and dominant Crx-mutant mouse retinas integrated with CRX and NRL ChIP-Seq datasets

    PMID:30084954

    Open questions at the time
    • Whether CRX directly binds the Mpp4 promoter or acts indirectly not fully resolved
    • Other transcription factors regulating MPP4 not identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include whether MPP4 mutations cause human retinal disease, the atomic-resolution structure of the MPP4 presynaptic scaffold, the direct vs. indirect nature of MPP4-PMCA and MPP4-TMEM16B interactions, and the precise electrophysiological impact of MPP4 loss on rod synaptic transmission in vivo.
  • No causative MPP4 mutations identified in human retinal dystrophy patients
  • No crystal or cryo-EM structure of the MPP4-containing complex
  • In vivo single-cell recordings from Mpp4-null rods not performed

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 7 GO:0005198 structural molecule activity 4
Localization
GO:0005886 plasma membrane 7 GO:0005929 cilium 1
Pathway
R-HSA-112316 Neuronal System 4 R-HSA-9609507 Protein localization 4
Partners
ANO2CRB1DLG1DLG4MPP5PMCAVELI3
Complex memberships
CRB1 apical complex (at OLM)MPP4-PSD95beta-Veli3 presynaptic scaffold

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 MPP4 was cloned as a retina-specific member of the p55 subfamily of MAGUK proteins, encoding a 637 amino acid protein with PDZ, SH3, and guanylate kinase-like (GUK) domains. High expression was demonstrated specifically in human retinal tissue, and genomic co-localization with the RP26 locus on chromosome 2q31-33 was identified, implicating MPP4 as a candidate gene for inherited retinopathy. EST expression profiling, cDNA cloning, sequence alignment, RT-PCR Genomics Medium 11414766
2003 MPP4 protein localizes to the connecting cilia and synaptic terminals of cone and rod photoreceptors in bovine and porcine retinas, as well as postsynaptic structures in the outer plexiform layer and three bands in the inner plexiform layer, suggesting roles at membrane-cytoskeleton interfaces in distinct photoreceptor compartments. Immunofluorescence microscopy using affinity-purified anti-MPP4 antibodies on retinal sections; Western blot of retinal extracts and transfected cells Investigative ophthalmology & visual science Medium 14638699
2003 Mouse Mpp4 is expressed postnatally (not embryonically) in retina, exclusively in photoreceptor cells including pineal gland, and Mpp4 protein localizes specifically at rod (but not cone) photoreceptor synaptic terminals, suggesting a role in targeting and assembly of specific molecules such as calcium channels at rod synapses. Microarray, real-time RT-PCR, in situ hybridization, immunofluorescence on retinal sections from wild-type and cone-specific GFP transgenic mice Biochemical and biophysical research communications Medium 12859944
2002 MPP4 contains an L27 domain (in addition to PDZ, SH3, and GUK domains) involved in protein-protein interactions, and a retina-specific isoform lacking 71 amino acids including the L27 domain was identified. MPP4 expression was confirmed to be highest in retina and also present in brain, with in situ hybridization localizing expression to photoreceptor cells. RT-PCR, RNA in situ hybridization, mutation analysis of MPP4 ORF in RP26 family and 300 RP patients Gene Medium 12384283
2004 MPP4 is a novel member of the CRB1-associated protein scaffold in the retina, colocalizing with CRB1 and MPP5 (PALS1) at the outer limiting membrane (OLM). MPP5 associates with both Mupp1 and Mpp4 at the sub-apical region adjacent to adherens junctions in photoreceptors. Immunohistochemistry, confocal microscopy on Crb1-/- mouse retinas; co-immunoprecipitation Journal of cell science Medium 15316081
2005 MPP4 directly interacts with MPP5 (PALS1) to be recruited into the CRB1 protein scaffold at the outer limiting membrane. 3D homology modeling provided evidence for a mechanism regulating homo- and heterodimer formation of MPP4 and MPP5 via their L27 domains. Yeast two-hybrid screening, GST pull-down, and immunoprecipitation validated MPP4-MPP5 direct interaction, and immunoelectron microscopy confirmed co-localization at the OLM. Yeast two-hybrid, GST pull-down, immunoprecipitation, immunohistochemistry, immunoelectron microscopy, 3D homology modeling Investigative ophthalmology & visual science High 15914641
2005 MPP4 localizes specifically to the synaptic terminals of photoreceptors (outer plexiform layer), distinct from MPP5 which localizes to apical OLM junctions. MPP4 directly interacts with Veli proteins (Veli1, Veli2, Veli3) via L27 heterodimerization in vitro. Veli3 co-localizes with MPP4 at photoreceptor synaptic terminals, suggesting MPP4 recruits Veli3 and its binding partners to this specialized region. In vitro L27 heterodimerization assay, immunofluorescence microscopy with specific polyclonal and monoclonal antibodies, co-localization studies in mouse retina The Journal of comparative neurology High 15558731
2006 Mpp4 knockout mice show that Mpp4 is essential for correct localization of Psd95 and Veli3 at the presynaptic photoreceptor membrane in the outer plexiform layer. Loss of Mpp4 leads to absence of Psd95 from presynaptic membranes of rods and cones and a significant reduction in total Psd95 protein levels, suggesting Mpp4 is involved in Psd95 turnover. Veli3 protein levels are unchanged. The Crb complex at the OLM is unaffected in Mpp4 knockouts. Mpp4 knockout mouse analysis, immunohistochemistry, Western blotting, scanning laser ophthalmology, electroretinography Human molecular genetics High 16520334
2006 MPP3 and Mpp4 both co-localize with DLG1 at the outer plexiform layer, and mouse Dlg1 forms separate complexes with Mpp3 and Mpp4 in vivo, identifying two distinct MAGUK scaffolding complexes at the photoreceptor synapse. Co-immunoprecipitation from mouse retina, immunohistochemistry, confocal microscopy The FEBS journal Medium 16519681
2007 Mpp4 is required for correct localization of plasma membrane Ca2+-ATPases (PMCAs) at rod photoreceptor synaptic terminals. In Mpp4-deficient mice, PMCAs are lost from presynaptic membranes; synaptic ribbons are enlarged (correlated with elevated Ca2+); SERCA2 levels increase and IP3RII distribution shifts away from synaptic terminals as compensatory responses. Mpp4 organizes a presynaptic complex including PMCAs, Veli3, and PSD95 that modulates Ca2+ homeostasis and synaptic transmission. Mpp4 knockout mouse analysis, immunohistochemistry, Western blotting, electroretinography, electron microscopy of synaptic ribbons, co-immunoprecipitation Human molecular genetics High 17341488
2008 Proteomic analysis of the MPP4-associated complex in mouse retina by immunoaffinity chromatography, 2D electrophoresis, and mass spectrometry identified Veli3, PSD95-beta (via L27 domain interaction), recoverin, and Hsc70 as components. The interaction of MPP4 specifically with the PSD95-beta isoform (not alpha) is mediated by their N-terminal L27 domains. Immunoaffinity chromatography with monoclonal anti-MPP4 antibody, 2D-PAGE, mass spectrometry, co-immunoprecipitation, L27 domain interaction assays Experimental eye research High 18955048
2009 TMEM16B, a Ca2+-dependent chloride channel, co-localizes with MPP4, PSD95, and VELI3 at photoreceptor ribbon synapses and is lost from photoreceptor membranes in MPP4-deficient mice, demonstrating that TMEM16B is recruited to photoreceptor presynaptic membranes via the MPP4-containing protein complex. Immunofluorescence co-localization in mouse retina, MPP4-knockout mouse analysis, Western blotting, electrophysiology (patch-clamp and halide-sensitive fluorescent protein assays for channel activity) The Journal of neuroscience High 19474308
2009 Both MPP4 and PSD95beta are essential for correct localization of PMCA at the photoreceptor presynaptic plasma membrane. C-terminal truncation of MPP4 causes loss of PSD95 and PMCA mislocalization. Silencing of Psd95 results in loss of presynaptic MPP4 and PMCA1, and expression of PSD95beta (but not alpha) via lentiviral delivery restores PMCA1 and MPP4 plasma membrane localization in Mpp4 mutant retinal explants, demonstrating isoform-specific interdependence. Mpp4 and Psd95 mutant mouse analysis, lentivirus-mediated molecular replacement in primary retinal explants, immunofluorescence, Western blotting Molecular and cellular neurosciences High 19233278
2018 CRX (cone-rod homeobox) transcription factor controls expression of MPP4 in photoreceptors, as validated by aberrant/reduced MPP4 immunostaining in Crx-null and dominant Crx-mutant retinas, placing MPP4 downstream of CRX in the regulatory pathway governing presynaptic active zone organization. Immunohistochemistry in Crx-/-, CrxRip/+ and CrxRip/Rip mouse retinas; integration with CRX- and NRL-ChIP-Seq data; transcriptome analysis Human molecular genetics Medium 30084954

Source papers

Stage 0 corpus · 77 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 2861 17081983
2005 Towards a proteome-scale map of the human protein-protein interaction network. Nature 2090 16189514
2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 1718 22658674
2005 A human protein-protein interaction network: a resource for annotating the proteome. Cell 1704 16169070
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2006 A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nature biotechnology 1336 16964243
2004 Large-scale characterization of HeLa cell nuclear phosphoproteins. Proceedings of the National Academy of Sciences of the United States of America 1159 15302935
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Molecular cell 973 22681889
2005 Nucleolar proteome dynamics. Nature 934 15635413
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2018 High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular cell 580 29395067
2017 Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science (New York, N.Y.) 533 28302793
2017 Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection. Molecular cell 527 28625552
1992 A conserved double-stranded RNA-binding domain. Proceedings of the National Academy of Sciences of the United States of America 505 1438302
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2010 Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. Journal of proteome research 422 20020773
2010 Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (New York, N.Y.) 421 20360068
2013 The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. The Journal of biological chemistry 413 23463506
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2011 IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nature immunology 405 21642987
2004 Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. Journal of cell science 208 15316081
2009 TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience 186 19474308
2012 Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism. International journal of cancer 135 22573479
1999 DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR. The Journal of biological chemistry 116 10400669
2016 Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging. The Journal of experimental medicine 84 27811054
2004 Identification and characterization of human MPP7 gene and mouse Mpp7 gene in silico. International journal of molecular medicine 80 14719143
1999 Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs. Molecular genetics and metabolism 66 10607473
2000 Alternative splicing in the human interleukin enhancer binding factor 3 (ILF3) gene. Gene 64 11167023
2005 MPP5 recruits MPP4 to the CRB1 complex in photoreceptors. Investigative ophthalmology & visual science 59 15914641
2006 Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse. Human molecular genetics 48 16520334
2017 DNA damage tolerance in hematopoietic stem and progenitor cells in mice. Proceedings of the National Academy of Sciences of the United States of America 46 28761001
2016 Enhanced diagnostic yield in Meckel-Gruber and Joubert syndrome through exome sequencing supplemented with split-read mapping. BMC medical genetics 43 26729329
2005 Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina. The Journal of comparative neurology 38 15558731
2007 Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals. Human molecular genetics 33 17341488
2000 Reconstitution of TCP80/NF90 translation inhibition activity in insect cells. Molecular genetics and metabolism 33 10873392
2021 CT based radiomic approach on first line pembrolizumab in lung cancer. Scientific reports 32 33758304
2006 MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane. The FEBS journal 32 16519681
2023 Epigenetic programming defines haematopoietic stem cell fate restriction. Nature cell biology 31 37127714
2022 Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors. Nature immunology 28 35354960
2021 Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients. Molecular cancer research : MCR 25 33811161
2017 Investigation of correlations between DNA methylation, suicidal behavior and aging. Bipolar disorders 24 28276657
2011 Comparison of proton and electron radiation effects on biological responses in liver, spleen and blood. International journal of radiation biology 24 22035456
2018 Cone-rod homeobox CRX controls presynaptic active zone formation in photoreceptors of mammalian retina. Human molecular genetics 22 30084954
2001 Cloning and characterization of the human retina-specific gene MPP4, a novel member of the p55 subfamily of MAGUK proteins. Genomics 22 11414766
2009 PSD95beta regulates plasma membrane Ca2+ pump localization at the photoreceptor synapse. Molecular and cellular neurosciences 20 19233278
2003 Cellular localization of the MPP4 protein in the mammalian retina. Investigative ophthalmology & visual science 20 14638699
2003 Cell cycle dependent intracellular distribution of two spliced isoforms of TCP/ILF3 proteins. Molecular genetics and metabolism 19 14654356
2018 A Novel Inducible Mouse Model of MLL-ENL-driven Mixed-lineage Acute Leukemia. HemaSphere 18 31723780
2013 Expression of oxidative stress and antioxidant defense genes in the kidney of inbred mice after intestinal ischemia and reperfusion. Acta cirurgica brasileira 17 24316858
2002 Characterization of MPP4, a gene highly expressed in photoreceptor cells, and mutation analysis in retinitis pigmentosa. Gene 16 12384283
2022 EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors. The Journal of experimental medicine 14 36048017
2003 Developmental and tissue expression patterns of mouse Mpp4 gene. Biochemical and biophysical research communications 13 12859944
2022 Germline ETV6 mutation promotes inflammation and disrupts lymphoid development of early hematopoietic progenitors. Experimental hematology 11 35803545
2018 A20 deficiency in multipotent progenitors perturbs quiescence of hematopoietic stem cells. Stem cell research 10 30445411
2023 Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions. The Journal of experimental medicine 8 37910046
2013 Simultaneous expression of the bacterial Dictyoglomus thermophilum xynB gene under three different Trichoderma reesei promoters. New biotechnology 8 24008227
2010 Identification of a novel peptide derived from the M-phase phosphoprotein 11 (MPP11) leukemic antigen recognized by human CD8+ cytotoxic T lymphocytes. Hematology/oncology and stem cell therapy 7 20231810
2022 Oral Trypanosoma cruzi Acute Infection in Mice Targets Primary Lymphoid Organs and Triggers Extramedullary Hematopoiesis. Frontiers in cellular and infection microbiology 5 35402296
2008 Proteomic analysis of the membrane palmitoylated protein-4 (MPP4)-associated protein complex in the retina. Experimental eye research 5 18955048
2024 CXCR4 signaling determines the fate of hematopoietic multipotent progenitors by stimulating mTOR activity and mitochondrial metabolism. Science signaling 3 39471249
2021 Lymphoid-biased hematopoietic stem cells and myeloid-biased hematopoietic progenitor cells have radioprotection activity. Blood science (Baltimore, Md.) 3 35402845
2025 Distinct transcriptional changes in hematopoietic progenitor subsets on LPS-induced emergency granulopoiesis. Experimental hematology 2 40316244
2025 Functional Comparison to Ezh2 Reveals PRC2-Independent Functions of Jarid2 in Hematopoietic Stem Cell Lineage Commitment. bioRxiv : the preprint server for biology 1 40791535
2024 WBP1L regulates hematopoietic stem cell function and T cell development. Frontiers in immunology 1 39555063
2026 Comparison with Ezh2 reveals the PRC2-dependent functions of Jarid2 in hematopoietic stem Cell lineage commitment. Stem cell reports 0 41650958
2024 An Investigation of the Inflammatory Landscape in the Brain and Bone Marrow of the APP/PS1 Mouse. Journal of Alzheimer's disease reports 0 39114548
2023 [Chronic Injury of Mice Bone Marrow Multipotent Hematopoietic Progenitor Cells Induced by Ionizing Radiation]. Zhongguo shi yan xue ye xue za zhi 0 37356954