Affinage

MMP10

Stromelysin-2 · UniProt P09238

Length
476 aa
Mass
54.2 kDa
Annotated
2026-06-10
95 papers in source corpus 36 papers cited in narrative 38 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MMP-10 (stromelysin-2) is a secreted, autocatalytically activatable zinc-dependent metalloproteinase that remodels the extracellular matrix and orchestrates downstream protease cascades during tissue repair, inflammation, and angiogenesis (PMID:15870107, PMID:9427548). As a proteolytic hub it both activates other matrix proteases—processing pro-MMP-1 to drive collagenolysis and capillary tube regression in endothelial cells (PMID:15870107) and processing proMMP-9 in macrophages to enable cartilage resorption during endochondral ossification (PMID:34173256)—and directly cleaves matrix and signaling substrates including laminin-5 in keratinocytes (controlling migration through β1-integrin/FAK signaling) (PMID:15371548) and nephrin in podocytes (PMID:40328459). Its catalytic domain is inhibited by TIMP-1 and TIMP-2, with the MMP-10·TIMP-1 interface defined crystallographically (PMID:22427646, PMID:35101440). A central biological role is in myeloid cells, where MMP-10 promotes macrophage migration and invasion over fibronectin (PMID:23691065), moderates inflammatory (M1) activation and favors M2 polarization via STAT3 (PMID:27316687, PMID:37844469), controls collagenolytic activity through MMP-8/MMP-13 expression (PMID:25927164), mediates TLR7 immune tolerance (PMID:30564235), and is required for efficient repair after lung infection, colitis, hindlimb ischemia, muscle injury, and bone fracture (PMID:27316687, PMID:23044923, PMID:24123596, PMID:25414484, PMID:34173256). MMP-10 transcription is integrated by numerous inputs, being induced by TGF-β/MEF2A (PMID:19935709), VEGF/Ets-1 (PMID:20432469), and SOX9/Wnt-β-catenin (PMID:38993791) and repressed by ZNF267, CHF1/Hey2, Ski-mediated H3K9 trimethylation, and the TRIM35/RelB non-canonical NF-κB axis (PMID:16054593, PMID:22079635, PMID:32198114, PMID:39865905). A missense variant (p.L245P) identified in families with premature myocardial infarction alters the MMP-10–TIMP-1 interface and renders macrophages less migratory and more pro-inflammatory, linking MMP-10 to cardiovascular disease (PMID:38806571).

Mechanistic history

Synthesis pass · year-by-year structured walk · 19 steps
  1. 1997 Medium

    Established the basic enzymatic nature of MMP-10—whether it behaves as a regulated zymogen—by showing the recombinant proenzyme undergoes autocatalytic processing.

    Evidence COS-cell expression of recombinant murine stromelysin-2 with APMA-induced autocatalytic activation

    PMID:9427548

    Open questions at the time
    • Physiological activator(s) in vivo not defined
    • Substrate repertoire of the activated enzyme not addressed
  2. 1998 Medium

    Demonstrated that MMP-10 exists as an active enzyme in tissue at sites of bone resorption, distinguishing it from the latent, matrix-bound behavior of MMP-3.

    Evidence Immunohistochemistry and in situ zymography on human and neonatal bone sections

    PMID:9662124

    Open questions at the time
    • Cellular activation mechanism in tissue not resolved
    • Direct substrates at resorption sites not identified
  3. 2004 High

    Defined a direct matrix substrate (laminin-5) and a cell-biological consequence, showing MMP-10 controls keratinocyte migration via regulated matrix degradation and integrin/FAK signaling.

    Evidence In vitro laminin-5 cleavage plus transgenic keratinocyte-targeted active MMP-10 mouse with wound-healing readouts

    PMID:15371548

    Open questions at the time
    • Cleavage site mapping not detailed
    • Whether endogenous MMP-10 levels reproduce overexpression phenotype unclear
  4. 2005 High

    Placed MMP-10 in a protease activation cascade by showing it activates pro-MMP-1 to drive endothelial capillary tube regression, establishing MMP-10 as an upstream amplifier of collagenolysis.

    Evidence siRNA knockdown, adenoviral overexpression, biochemical activation assays in 3D collagen tube-regression model

    PMID:15870107

    Open questions at the time
    • In vivo relevance of the cascade beyond the 3D model not tested
    • Endogenous serine protease activators of pro-MMP-10 in vivo not confirmed
  5. 2005 Medium

    Began mapping transcriptional control by identifying ZNF267 as a KRAB-domain repressor binding the MMP-10 promoter.

    Evidence Reporter assays, ChIP, and GAL4 fusions in hepatic stellate cells

    PMID:16054593

    Open questions at the time
    • Physiological contexts of ZNF267 repression unknown
    • Single-cell-type analysis only
  6. 2009 High

    Identified an inducible transcriptional axis, showing TGF-β drives MMP-10 via HDAC degradation and MEF2A activation at the promoter.

    Evidence Luciferase reporters, ChIP, siRNA/overexpression, and proteasome inhibition in mammary epithelial cells

    PMID:19935709

    Open questions at the time
    • Cell-type generality of the TGF-β/MEF2A axis not established
    • Interplay with repressors not addressed
  7. 2010 Medium

    Connected angiogenic signaling to MMP-10, showing VEGF induces it through Ets-1/PI3K/MAPK and that MMP-10 is required for endothelial migration and tube/vessel formation.

    Evidence qRT-PCR, siRNA, tube formation and matrigel plug assays with pathway inhibitors and Ets-1 reporter

    PMID:20432469

    Open questions at the time
    • Direct MMP-10 substrates driving angiogenesis not identified
    • Single-lab in vivo confirmation
  8. 2011 Medium

    Extended transcriptional regulation with multiple inputs—CHF1/Hey2 E-box repression, β1-integrin/ERK induction in lymphatics, and CRP-driven ERK/JAK1 induction in cardiomyocytes—mapping context-specific control of MMP-10.

    Evidence Reporter assays with E-box mutagenesis, siRNA, zymography and pharmacological pathway inhibition across smooth muscle, lymphatic endothelial, and cardiomyocyte systems

    PMID:21406228 PMID:22079635 PMID:22142512

    Open questions at the time
    • No genetic confirmation for the CRP cardiomyocyte axis
    • How these inputs are integrated in vivo unresolved
  9. 2012 High

    Provided the structural and kinetic basis for inhibitor regulation, solving the MMP-10cd·TIMP-1 structure and quantifying TIMP-1/TIMP-2 inhibition relative to MMP-3.

    Evidence X-ray crystallography at 1.9 Å with kinetic inhibition assays and comparative structural analysis

    PMID:22427646

    Open questions at the time
    • No structure of full-length or substrate-bound enzyme
    • Catalytic domain only, prodomain interactions not captured
  10. 2012 High

    Identified the myeloid source and protective function of MMP-10 in intestinal inflammation, showing bone marrow-derived MMP-10 limits colitis severity and dysplasia.

    Evidence Mmp10⁻/⁻ mice, DSS colitis, bone marrow transplant and immunohistochemistry

    PMID:23044923

    Open questions at the time
    • Molecular substrate mediating protection not identified
    • Mechanism of dysplasia suppression unclear
  11. 2013 High

    Established a cell-autonomous requirement for MMP-10 in macrophage migration and invasion, rescuable by recombinant enzyme.

    Evidence Time-lapse microscopy, RNAi, Mmp10⁻/⁻ macrophages and recombinant MMP-10 rescue across migration/invasion assays

    PMID:23691065

    Open questions at the time
    • Substrate(s) on fibronectin driving migration not defined
    • Receptor/signaling coupling not mapped
  12. 2014 High

    Defined MMP-10 as a required effector of tissue repair across muscle and ischemia, linking it to VEGF/Akt, CXCR4/SDF1 signaling, and chemokine (Cxcl1) suppression.

    Evidence Mmp10⁻/⁻ mice, in vivo siRNA, recombinant MMP-10 rescue, and pharmacological CXCR4 antagonism in injury and ischemia models

    PMID:24123596 PMID:24548137 PMID:25414484

    Open questions at the time
    • Direct substrates underlying VEGF/Akt activation unidentified
    • Mechanism of transcriptional Cxcl1 suppression unresolved
  13. 2015 High

    Showed M2 macrophage-derived MMP-10 controls wound collagenolysis indirectly by regulating MMP-8/MMP-13 expression, shaping tissue stiffness.

    Evidence Mmp10⁻/⁻ mice, wound model, macrophage ablation/adoptive transfer, collagen and biomechanical assays

    PMID:25927164

    Open questions at the time
    • Mechanism by which MMP-10 controls collagenase expression not defined
    • Direct vs indirect proteolysis contributions unseparated
  14. 2016 High

    Demonstrated MMP-10 moderates macrophage inflammatory polarization in vivo, with the protective effect being macrophage-intrinsic.

    Evidence Mmp10⁻/⁻ mice, P. aeruginosa infection, adoptive BMDM transfer and genome-wide expression analysis; plus AJUBA-driven MMP10 induction in carcinoma

    PMID:27172796 PMID:27316687

    Open questions at the time
    • Molecular target through which MMP-10 dampens M1 signaling unknown
    • Link between catalytic activity and transcriptional resolution unclear
  15. 2018 Medium

    Broadened MMP-10's immunomodulatory role to TLR7 tolerance and ischemic neuroprotection, showing it is required for macrophage hypo-responsiveness and can be thrombolytic/barrier-protective.

    Evidence Mmp10⁻/⁻ mice in TLR7 tolerance model; recombinant MMP-10 with antibody neutralization in stroke model and endothelial/neuron cultures

    PMID:28379489 PMID:30564235

    Open questions at the time
    • Direct substrates in tolerance and neuroprotection not identified
    • Single-lab studies
  16. 2021 High

    Resolved a defined biochemical mechanism in bone—MMP-10 processes proMMP-9 in macrophages to enable cartilage resorption during fracture healing.

    Evidence Mmp10⁻/⁻ mice, bone marrow transplant rescue, proMMP-9 processing and gelatinase activity assays in fracture histology

    PMID:34173256

    Open questions at the time
    • Whether proMMP-9 is a direct cleavage substrate of MMP-10 not crystallographically confirmed
    • Other resorption substrates unexamined
  17. 2022 Medium

    Extended TIMP-1 interface understanding and chondrocyte function, engineering MMP-3-selective TIMP-1 variants and showing MMP-10 is required for terminal chondrocyte differentiation/survival.

    Evidence Directed evolution with crystallography of MMP-3/MMP-10 complexes; shRNA knockdown in hypertrophic chondrocytes with marker and apoptosis assays; plus Ski-mediated H3K9me3 repression and miR-148/152 regulation

    PMID:32198114 PMID:34979166 PMID:35101440 PMID:35818290

    Open questions at the time
    • Pro-TNF-α cleavage by MMP-10 inferred functionally rather than directly demonstrated
    • Chondrocyte study limited to single lab
  18. 2023 High

    Defined a transcription-to-function loop in liver disease, showing PPARγ directly induces MMP-10 which then drives M2 polarization via STAT3 to alleviate steatohepatitis.

    Evidence MMP10-OE/KO mice on HFD, PPARγ ChIP, Kupffer cell transfection and STAT3 pathway analysis

    PMID:37844469

    Open questions at the time
    • Mechanism by which secreted MMP-10 activates STAT3 not defined
    • Direct vs paracrine action unclear
  19. 2025 Medium

    Identified new direct substrates and regulatory and disease links—nephrin cleavage in podocyte injury, endothelial TRIM35/RelB control of MMP-10 secretion driving vascular calcification, and a PAR1-independent neuronal Ca²⁺ pathway.

    Evidence Mmp10⁻/⁻ mice with in vitro nephrin cleavage; conditional endothelial TRIM35 KO with K63-ubiquitination assays; DRG neuron Ca²⁺ imaging (preprint)

    PMID:39865905 PMID:40328459

    Open questions at the time
    • Neuronal receptor mediating Ca²⁺ mobilization unidentified (preprint, single method)
    • Whether nephrin is a direct vs cascade-mediated substrate in vivo not fully resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • The unifying molecular logic linking MMP-10's diverse catalytic activities (matrix cleavage, protease activation) to its consistent transcriptional/immunomodulatory phenotypes remains unresolved.
  • No comprehensive substrate degradome
  • How a secreted protease alters intracellular transcriptional programs (e.g., M1/M2, Cxcl1) mechanistically unexplained
  • No full-length or substrate-bound structure

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016787 hydrolase activity 5 GO:0140096 catalytic activity, acting on a protein 4 GO:0016740 transferase activity 2
Localization
GO:0005576 extracellular region 4 GO:0031012 extracellular matrix 3
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-1474244 Extracellular matrix organization 4 R-HSA-168256 Immune System 4 R-HSA-1643685 Disease 3
Partners
MMP1MMP9TIMP1TIMP2

Evidence

Reading pass · 38 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 MMP-10 activates pro-MMP-1, and both MMP-10 and MMP-1 are required for capillary tube regression in 3D collagen matrices; serine proteases (plasma kallikrein, trypsin, neutrophil elastase, cathepsin G, tryptase, chymase) activate pro-MMP-10, which in turn activates MMP-1 to drive collagen proteolysis, tube collapse, and endothelial cell apoptosis. siRNA silencing of MMP-10 markedly delayed regression, while adenoviral overexpression of MMP-10 accelerated it. siRNA knockdown, adenoviral overexpression, in vitro capillary tube regression assay in 3D collagen matrices, zymography, biochemical MMP activation assays Journal of cell science High 15870107
2004 Active stromelysin-2 (MMP-10) degrades laminin-5 in vitro, and constitutively active MMP-10 expressed in keratinocytes in vivo disrupts laminin-5 deposition, mislocalizes β1-integrins and phosphorylated focal adhesion kinase at the wound edge, and increases keratinocyte apoptosis, indicating MMP-10 controls keratinocyte migration through regulated matrix degradation. Transgenic mouse model (constitutively active MMP-10 in keratinocytes), in vitro laminin-5 degradation assay, immunohistochemistry, skin wound-healing model Molecular biology of the cell High 15371548
2012 Crystal structure of TIMP-1 bound to the MMP-10 catalytic domain solved at 1.9 Å; TIMP-1 inhibits MMP-10cd with Ki = 1.1 × 10⁻⁹ M and TIMP-2 with Ki = 5.8 × 10⁻⁹ M, both ~10-fold weaker than their inhibition of the closely related MMP-3. Structural comparison with MMP-3·TIMP-1 revealed interface differences explaining the differential binding. X-ray crystallography (1.9 Å resolution, molecular replacement), kinetic inhibition assays (multiple approaches), comparative structural analysis The Journal of biological chemistry High 22427646
2013 MMP10 is required for macrophage migration and invasion; RNAi silencing of MMP10 in primary macrophages markedly reduced migration (reversed by exogenous active MMP10 protein), and Mmp10⁻/⁻ bone marrow-derived macrophages showed significantly reduced migration over fibronectin and impaired invasion into Matrigel supplemented with fibronectin. Time-lapse microscopy, RNAi silencing, Mmp10⁻/⁻ knockout macrophages, exogenous recombinant MMP10 rescue, 2D migration and Matrigel invasion assays PloS one High 23691065
2016 MMP10 moderates macrophage inflammatory activation: Mmp10⁻/⁻ mice showed ~3-fold more macrophages in infected lungs, elevated M1 markers and reduced M2 markers; global gene expression showed infection-induced transcriptional changes persisted in Mmp10⁻/⁻ macrophages. Adoptive transfer of wild-type BMDMs normalized morbidity in Mmp10⁻/⁻ recipients, demonstrating the protective effect is macrophage-derived MMP10. Mmp10⁻/⁻ knockout mice, Pseudomonas aeruginosa infection model, adoptive transfer of BMDMs, genome-wide gene expression analysis, flow cytometry for macrophage markers Journal of immunology High 27316687
2015 MMP-10 from alternatively activated (M2) resident macrophages regulates collagenolytic activity in wounds by controlling expression of metallocollagenases MMP-8 and MMP-13 (particularly MMP-13); Mmp10⁻/⁻ wounds showed increased collagen deposition, skin stiffness, and reduced collagenolytic activity. Ablation and adoptive transfer experiments confirmed the effect is macrophage-derived. Mmp10⁻/⁻ knockout mice, wound healing model, macrophage ablation and adoptive transfer, collagen assays, biomechanical testing, cell-based models The Journal of investigative dermatology High 25927164
2012 Loss of MMP10 exacerbates DSS-induced colitis and impairs resolution of inflammation; MMP10 is produced predominantly by infiltrating myeloid cells in murine and human colitis, and bone marrow transplant experiments confirmed that bone marrow-derived MMP10 contributes to disease severity. Mmp10⁻/⁻ mice had higher propensity for dysplasia after repeated DSS exposure. Mmp10⁻/⁻ knockout mice, DSS colitis model, bone marrow transplantation, immunohistochemistry, histological scoring Laboratory investigation High 23044923
2009 TGF-β transcriptionally induces MMP-10 in mammary epithelial cells through MEF2A: TGF-β promotes proteasome-dependent degradation of class IIa HDACs, leading to increased acetylation of MEF2A and core histones around the MEF2 site of the MMP-10 promoter, driving transactivation. Knockdown of MEF2A reduced MMP-10 induction; knockdown of class IIa HDACs increased it. Reporter gene (luciferase) assays, siRNA knockdown, overexpression experiments, chromatin immunoprecipitation (ChIP), real-time PCR, proteasome inhibitor experiments Oncogene High 19935709
2005 Zinc finger protein ZNF267 is a negative transcriptional repressor of MMP-10: ZNF267 is constitutively nuclear, its KRAB-A domain mediates repressor activity, it binds the MMP-10 promoter region (demonstrated by ChIP), and its overexpression reduces MMP-10 reporter activity in hepatic stellate cells. Microarray, RNase protection assay, reporter gene assay, chromatin immunoprecipitation (ChIP), GAL4 fusion constructs, fluorescent protein localization Biochemical and biophysical research communications Medium 16054593
2010 MMP-10 transcription in endothelial cells is induced by VEGF in a time- and dose-dependent manner; MMP-10 expression is mediated by the Ets-1 transcription factor but not ERP/NET/ELK3, and via PI3K and MAPK signaling pathways. MMP-10 siRNA inhibited VEGF-induced endothelial cell migration and tube formation in vitro, and vessel formation in matrigel plugs in vivo. Quantitative RT-PCR, siRNA knockdown, migration and tube formation assays, in vivo matrigel plug assay, pharmacological inhibitors of PI3K and MAPK, luciferase reporter for Ets-1 Journal of cellular physiology Medium 20432469
2011 C-reactive protein (CRP) promotes MMP-10 expression and activity in cardiomyocytes via c-Raf/MEK/ERK and JAK1/ERK signaling pathways, with DNA binding sites for AP-1 and STAT3 in the nucleus mediating the effect; blocking ERK1/2 (U0126) or JAK1 (piceatannol) significantly decreased CRP-induced MMP-10 expression. Real-time PCR, Western blot, casein zymography, pharmacological pathway inhibitors, phospho-specific antibodies, cell culture Cellular signalling Medium 22142512
2011 β1 integrin signaling via the ERK/MAPK pathway upregulates MMP-10 mRNA and protein expression in human lymphatic endothelial cells, and MMP-10 is required for collagen I-induced lymphatic tubulogenesis; knockdown of MMP-10 impaired tubulogenesis. Protein-based screening, siRNA knockdown, ERK/MAPK pathway analysis, lymphatic endothelial cell tubulogenesis assay Matrix biology Medium 21406228
2014 MMP-10 deficiency impairs skeletal muscle regeneration after injury: Mmp10⁻/⁻ muscles displayed reduced endothelial cell recruitment, diminished extracellular matrix proteins, decreased collagen deposition, decreased fiber size, and delayed regeneration. MMP-10 mRNA silencing in vivo reduced muscle regeneration, while recombinant MMP-10 accelerated repair. MMP-10-mediated muscle repair was associated with VEGF/Akt signaling. Mmp10⁻/⁻ knockout mice, notexin injury model, mdx muscular dystrophy model, siRNA in vivo silencing, recombinant MMP-10 treatment, immunohistochemistry, Western blot Stem cells High 24123596
2014 CXCR4/SDF1-regulated muscle repair is dependent on MMP-10 activity: siRNA silencing of SDF1 or CXCR4 in injured muscles impaired regeneration, and MMP-10 was identified as the downstream effector of this axis. SDF1 ligand addition accelerated repair, and CXCR4 antagonism (AMD3100) delayed it, linking the CXCR4/SDF1 pathway to MMP-10-dependent matrix remodeling in muscle repair. In vivo siRNA silencing of SDF1, CXCR4, pharmacological CXCR4 antagonism (AMD3100), notexin injury model, functional and histological analysis Stem cells and development Medium 24548137
2014 MMP-10 functions are required for efficient tissue repair after hind limb ischemia; Mmp10⁻/⁻ mice showed delayed reperfusion, increased necrosis, and excessive neutrophil/macrophage infiltration. MMP-10 deficiency led to higher Cxcl1 mRNA and protein levels, revealing a transcriptional inhibitory role for MMP-10 on Cxcl1. Injection of MMP-10 into Mmp10⁻/⁻ mice rescued the phenotype. Mmp10⁻/⁻ knockout mice, femoral artery excision ischemia model, small animal PET, immunohistochemistry, siRNA knockdown of MMP-10 in vivo, recombinant MMP-10 rescue FASEB journal High 25414484
2021 During secondary fracture healing, MMP-10 is expressed by hematopoietic cells and is required for cartilage resorption; Mmp10⁻/⁻ mice showed delayed cartilage resorption and TRAP-positive cell accumulation at 14 days post-fracture. The phenotype was rescued by wild-type bone marrow transplant. MMP-10 functions in macrophages to promote proMMP-9 processing and gelatinase activity required for endochondral ossification. Mmp10⁻/⁻ knockout mice, fracture healing model, bone marrow transplantation rescue, proMMP-9 processing assay, TRAP staining, immunohistochemistry Journal of bone and mineral research High 34173256
2018 MMP10 functions as a thrombolytic and neuroprotective agent in ischemic stroke; recombinant MMP10 reduced infarct size in a thrombin-induced middle cerebral artery occlusion model, and in vitro MMP10 reduced tPA-promoted endothelial ionic permeability, preserved claudin-5, decreased ERK1/2 activation, prevented tPA-mediated neuronal excitotoxicity and calcium influx. These effects were blocked by an anti-MMP10 monoclonal antibody. In vivo murine ischemic stroke model, brain endothelial cell and neuron cultures, Western blot for claudin-5, ERK1/2 phosphorylation, calcium imaging, anti-MMP10 antibody neutralization Cardiovascular research Medium 28379489
2018 MMP10 moderates TLR7-induced immune tolerance in skin macrophages: Mmp10⁻/⁻ mice failed to develop hypo-responsiveness to repeated TLR7 (imiquimod) stimulation, with failure to upregulate negative TLR regulators (TNFAIP3, IRAK3) and immunosuppressive cytokines (IL-10, TGFβ1). In vitro, prior IMQ exposure made wild-type BMDMs refractory to re-stimulation but not Mmp10⁻/⁻ macrophages. Mmp10⁻/⁻ knockout mice, in vivo TLR7 tolerance model, BMDM cultures, cytokine/gene expression analysis Frontiers in immunology Medium 30564235
2020 Recombinant MMP-10 induces osteogenic, fibrotic, and inflammatory markers in aortic valve interstitial cells (interleukin-1β, α-SMA, vimentin, collagen, BMP-4, Sox9, osteopontin, BMP-9, and Smad 1/5/8) and promotes cell mineralization via Akt phosphorylation; these effects were prevented by TIMP-1 or an anti-MMP-10 antibody. MMP-10 co-localizes with calcification markers (Runx2, SOX9) in stenotic aortic valves. In vitro treatment of primary human aortic valve interstitial cells with recombinant MMP-10, TIMP-1 inhibition, anti-MMP-10 antibody neutralization, Akt phosphorylation assay, calcification (mineralization) assay, immunohistochemistry Arteriosclerosis, thrombosis, and vascular biology Medium 32188274
2017 MMP10 facilitates clearance of long multiwalled carbon nanotubes (MWCNTs) from lung and moderates macrophage inflammatory activation and survival; Mmp10⁻/⁻ mice showed impaired pulmonary clearance of MWCNTs and reduced macrophage survival, with enhanced caspase-3-dependent cell death and elevated IL-6 and IL-1β in Mmp10⁻/⁻ macrophages. Mmp10⁻/⁻ knockout mice, oropharyngeal aspiration of MWCNTs, alveolar macrophage and BMDM cultures, caspase-3 assay, cytokine analysis, gene expression International journal of nanomedicine Medium 28223796
2022 Directed evolution of yeast-displayed TIMP-1 yielded variants highly selective for MMP-3 over MMP-10. Protein crystal structures and models of MMP-3-selective TIMP-1 variants bound to MMP-3 and counter-target MMP-10 showed that structural alterations in N- and C-terminal TIMP-1 domains create favorable interactions with MMP-3 and disrupt unique interactions with MMP-10, defining the binding interface determinants of stromelysin selectivity. Directed evolution (yeast display, counter-selective screening), X-ray crystallography of protein complexes, structural modeling The Journal of biological chemistry High 35101440
2011 CHF1/Hey2 is a direct transcriptional repressor of MMP10: loss or knockdown of CHF1/Hey2 in vascular smooth muscle cells increases MMP10 expression and activity. A 2.5 kb MMP10 promoter region contains 12 E-boxes mediating constitutive activity and CHF1/Hey2 repression; mutation of these E-boxes abolished repression and unmasked an activator function for CHF1/Hey2. Luciferase reporter assays, siRNA knockdown of CHF1/Hey2, E-box mutagenesis, gene expression analysis in smooth muscle cells Biochemical and biophysical research communications Medium 22079635
2016 AJUBA promotes migration and invasion of esophageal squamous cell carcinoma cells by upregulating MMP10 and MMP13 expression through activation of the ERK1/2 signaling pathway; AJUBA knockdown reduced migration/invasion and decreased MMP10/MMP13 levels, while AJUBA overexpression had the opposite effect, both in vitro and in vivo. RNA sequencing, siRNA knockdown and overexpression of AJUBA, Western blot, migration and invasion assays, in vivo xenograft models, ERK1/2 pathway analysis Oncotarget Medium 27172796
2014 YY1 suppresses PDAC invasion and metastasis by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism: YY1 expression negatively correlated with MMP10 levels; YY1 overexpression suppressed invasion/metastasis and reduced MMP10, while YY1 knockdown enhanced them. Luciferase assays and pathway blockage experiments placed MMP10 downstream of YY1/MUC4/ErbB2/p38/MEF2C. Digital gene expression sequencing, siRNA knockdown, overexpression, luciferase reporter assays, signaling pathway inhibitors, in vivo xenograft and tail vein metastasis models Molecular cancer Medium 24884523
2009 IL-6 regulates MMP-10 expression via the JAK2/STAT3 pathway in lung adenocarcinoma cells: IL-6 moderately reduced MMP-10 mRNA but significantly enhanced MMP-10 protein. The JAK2 inhibitor AG490 blocked both IL-6-induced STAT3 upregulation and the bidirectional IL-6 effects on MMP-10 mRNA and protein levels. Real-time RT-PCR, Western blot, pharmacological JAK2 inhibition (AG490), A549 cell culture Anticancer research Low 20032397
1997 Recombinant murine stromelysin-2 (MMP-10) produced in COS cells is secreted as a proenzyme that undergoes autocatalytic processing upon addition of the organomercurial salt APMA, establishing that MMP-10 is an autocatalytically activatable metalloproteinase. COS cell expression of recombinant protein, organomercurial (APMA)-induced autocatalytic processing assay Gene Medium 9427548
2022 MMP10 is required for proMMP-9 processing in macrophages during bone fracture healing; Mmp10⁻/⁻ macrophages showed reduced gelatinase activity and lack of proMMP-9 processing, contributing to impaired cartilage resorption and delayed vascular invasion during endochondral ossification. Mmp10⁻/⁻ knockout mice, wild-type bone marrow transplant rescue, proMMP-9 processing assay, gelatinase activity assay, fracture healing histology Journal of bone and mineral research High 34173256
2023 MMP10 alleviates non-alcoholic steatohepatitis by promoting M2 macrophage polarization via STAT3 signaling: PPARγ binds the MMP10 promoter and upregulates MMP10 expression upon IL-4 stimulation. MMP10 overexpression activated downstream STAT3 signaling to induce M2 polarization, reducing pro-inflammatory IL-1β and TNF-α and increasing IL-10. MMP10-KO mice showed worse NASH phenotype on HFD. MMP10-OE and MMP10-KO mice on HFD, PPARγ-OE, ChIP (PPARγ binding to MMP10 promoter), Kupffer cell transfection, IL-4 stimulation, STAT3 pathway analysis, HFD NASH model International immunopharmacology High 37844469
2022 MMP-10 knockdown in hypertrophic chondrocytes decreases expression of Col II, Col X, Runx2, and MMP-13, and significantly increases chondrocyte apoptosis, indicating MMP-10 is required for terminal chondrocyte differentiation and survival during endochondral osteogenesis. MMP-10 shRNA knockdown in ATDC5 hypertrophic chondrocytes, flow cytometry (apoptosis), RT-PCR, Western blot, in vivo rat/human KBD cartilage analysis Cartilage Medium 35818290
2025 MMP10 induces Ca²⁺ mobilization in dorsal root ganglion (DRG) neurons through a PAR1-independent mechanism (in contrast to MMP3, MMP8, and MMP9 which act via PAR1), establishing a distinct neuronal signaling pathway for MMP10. Intracellular Ca²⁺ imaging in DRG neurons, PAR1 pharmacological blockade, comparison with other MMPs bioRxivpreprint Low
2025 Endothelial TRIM35 inhibits MMP10 expression and secretion by promoting K63-linked ubiquitination of RelB, maintaining its nuclear localization to inhibit MMP10 transcription through the non-canonical NF-κB signaling pathway; conditional endothelial TRIM35 knockout leads to increased MMP10 secretion, which drives smooth muscle cell calcification in vascular grafts. Conditional endothelial TRIM35 KO mice, arterial isograft model, single-cell analysis, co-culture experiments, ubiquitination assays (K63-linked), RelB localization studies, in situ MMP10 targeting Advanced science Medium 39865905
2024 NOX5-generated ROS upregulates MMP-10 expression in endothelial cells via the redox-sensitive JNK/AP-1 signaling pathway, promoting endothelial cell migration; NOX5 and MMP-10 silencing prevented this pro-migratory effect, and effects were enhanced by angiotensin II. NOX5 overexpression and siRNA silencing in human endothelial cells, MMP-10 siRNA, wound healing assay, JNK/AP-1 pathway inhibition, MMP-10 promoter activity assay, in vivo NOX5-expressing mouse hearts Antioxidants Medium 39456453
2025 Active MMP-10 cleaves nephrin in vitro, contributing to podocyte injury; in vivo, MMP-10 knockout mice showed less albuminuria and reduced pro-inflammatory/pro-fibrotic gene expression in anti-GBM nephritis, and MMP-10 overexpression in podocytes upregulated inflammatory responses to TNF-α while MMP-10 knockdown mitigated inflammation. Mmp10⁻/⁻ knockout mice, anti-GBM nephritis model, GC-A/MMP-10 double KO mice, in vitro nephrin cleavage assay, podocyte MMP-10 OE and KD, co-culture of podocytes with endothelial cells, Western blot Nephrology, dialysis, transplantation Medium 40328459
2025 SOX9 directly transcriptionally activates MMP10 expression (identified by ChIP-seq), and MMP10 promotes ECM degradation downstream of SOX9 in tracheal fibroblasts via the Wnt/β-catenin signaling pathway; SOX9 overexpression increased and SOX9 siRNA decreased MMP10 expression, fibroblast activation, and ECM deposition. RNA-seq, ChIP-seq, adenoviral SOX9 overexpression, siRNA knockdown, Wnt/β-catenin pathway analysis, in vivo tracheal fibrosis model, MMP10 expression quantification Genes & diseases Medium 38993791
2024 A missense variant p.L245P in MMP10 (identified in families with premature myocardial infarction) alters the MMP10-TIMP1 binding interface, reduces total free binding energy, and minimizes the substrate-binding cleft volume (molecular dynamics simulations). In macrophages transfected with the variant, cells were more adherent, less migratory, and secreted higher levels of pro-inflammatory CXCL1 and CXCL8 compared to wild-type MMP10. Whole-exome sequencing (variant identification), molecular dynamics simulations, macrophage transfection with WT and p.L245P cDNA, adhesion assay, migration assay, ELISA for chemokines Scientific reports Medium 38806571
1998 SL-2 (MMP-10) in developing human bone is produced in an active form (confirmed by in situ zymography) at sites of resorption in endochondral ossification, the chondro-osseous junction (chondrocytes), and in osteoclasts and mononuclear marrow cells, with associated matrix degradation activity. This differs from SL-1 (MMP-3), which is present predominantly as a latent matrix-bound proenzyme. Immunohistochemistry, in situ zymography on human osteophytic and neonatal rib bone sections Bone Medium 9662124
2020 Ski associates with the pericentromeric region and promoters of Mmp10 (along with Mmp3 and Mmp13) on chromosome 9 during mitosis, promotes H3K9 tri-methylation at these loci, and is required for transcriptional repression of these genes during M/G1 transition; Ski⁻/⁻ MEFs show increased Mmp activity and derepressed Mmp10 expression. Chromatin immunoprecipitation (ChIP) of Ski at Mmp10 promoter, H3K9 methylation/acetylation assays, Ski⁻/⁻ MEFs, differential gene expression assays, MMP activity assay Journal of molecular biology Medium 32198114
2022 miR-148/152 family members negatively regulate MMP10; deficiency of any member increases MMP10 (and MMP13) expression, disrupts intestinal barrier, and activates NF-κB signaling in part through MMP10-mediated cleavage of pro-TNF-α into bioactive fragments. Blocking NF-κB exerted a restorative effect only in knockout mice. Individual and full-family miR-148/152 KO mice, colitis/CAC models (DSS/AOM), MMP10 expression analysis, intestinal barrier assays, NF-κB pathway analysis, NF-κB blockade experiments Cancer letters Medium 34979166

Source papers

Stage 0 corpus · 95 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10. Annals of the rheumatic diseases 196 12379519
2005 MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices. Journal of cell science 164 15870107
2004 Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin. Molecular biology of the cell 110 15371548
2014 Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism. Molecular cancer 103 24884523
2012 Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure. The Journal of biological chemistry 94 22427646
1998 Stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) expression in developing human bone: potential roles in skeletal development. Bone 92 9662124
2009 Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study. Journal of proteome research 89 19317417
2013 Macrophage migration and invasion is regulated by MMP10 expression. PloS one 80 23691065
2004 Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing. Scandinavian journal of gastroenterology 79 15545168
2016 Stromelysin-2 (MMP10) Moderates Inflammation by Controlling Macrophage Activation. Journal of immunology (Baltimore, Md. : 1950) 78 27316687
2003 Human diabetic corneas preserve wound healing, basement membrane, integrin and MMP-10 differences from normal corneas in organ culture. Experimental eye research 77 12873452
2008 Metalloproteinases and atherothrombosis: MMP-10 mediates vascular remodeling promoted by inflammatory stimuli. Frontiers in bioscience : a journal and virtual library 76 17981764
2015 MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages. The Journal of investigative dermatology 74 25927164
2001 Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers. British journal of cancer 71 11237387
2010 Expression profiling of ETS and MMP factors in VEGF-activated endothelial cells: role of MMP-10 in VEGF-induced angiogenesis. Journal of cellular physiology 66 20432469
2009 Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 65 19489686
2012 Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. Laboratory investigation; a journal of technical methods and pathology 63 23044923
2003 Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas. Anticancer research 63 14666700
2004 MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas. Neoplasia (New York, N.Y.) 56 15720804
2020 A Role for MMP-10 (Matrix Metalloproteinase-10) in Calcific Aortic Valve Stenosis. Arteriosclerosis, thrombosis, and vascular biology 51 32188274
2013 Enhanced wound healing, kinase and stem cell marker expression in diabetic organ-cultured human corneas upon MMP-10 and cathepsin F gene silencing. Investigative ophthalmology & visual science 44 24255036
2014 MMP-10 is required for efficient muscle regeneration in mouse models of injury and muscular dystrophy. Stem cells (Dayton, Ohio) 41 24123596
2009 Transcriptional induction of MMP-10 by TGF-beta, mediated by activation of MEF2A and downregulation of class IIa HDACs. Oncogene 41 19935709
2010 Age- and gender-dependent changes in connective tissue remodeling: physiological differences in circulating MMP-3, MMP-10, TIMP-1 and TIMP-2 level. Gerontology 39 20215736
2019 Contribution of airway eosinophils in airway wall remodeling in asthma: Role of MMP-10 and MET. Allergy 38 30667542
2009 IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line. Anticancer research 38 20032397
2008 Selective iNOS inhibitor 1400W enhances anti-catabolic IL-10 and reduces destructive MMP-10 in OA cartilage. Survey of the effects of 1400W on inflammatory mediators produced by OA cartilage as detected by protein antibody array. Clinical and experimental rheumatology 37 18565249
2019 Methanogenesis marker protein 10 (Mmp10) from Methanosarcina acetivorans is a radical S-adenosylmethionine methylase that unexpectedly requires cobalamin. The Journal of biological chemistry 36 31113866
2022 MMP-10 from M1 macrophages promotes pulmonary vascular remodeling and pulmonary arterial hypertension. International journal of biological sciences 35 34975336
2016 AJUBA promotes the migration and invasion of esophageal squamous cell carcinoma cells through upregulation of MMP10 and MMP13 expression. Oncotarget 35 27172796
2014 The CXCR4/SDF1 axis improves muscle regeneration through MMP-10 activity. Stem cells and development 35 24548137
2007 Expression of MMP-9, MMP-10 and TNF-alpha and lack of epithelial MMP-1 and MMP-26 characterize pyoderma gangrenosum. Journal of cutaneous pathology 35 18001410
2012 The immunohistochemical characterization of MMP-2, MMP-10, TIMP-1, TIMP-2, and podoplanin in oral squamous cell carcinoma. Oral surgery, oral medicine, oral pathology and oral radiology 34 22769410
2020 Palmatine ameliorates Helicobacter pylori-induced chronic atrophic gastritis by inhibiting MMP-10 through ADAM17/EGFR. European journal of pharmacology 33 32569674
2017 Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 asa candidate to predict metastases. Oral oncology 31 28939077
2013 Activation of the PKC pathway stimulates ovarian cancer cell proliferation, migration, and expression of MMP7 and MMP10. Biology of reproduction 31 23843242
2004 Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation. Biological chemistry 30 14977049
2018 Combined sustained release of BMP2 and MMP10 accelerates bone formation and mineralization of calvaria critical size defect in mice. Drug delivery 28 29516759
2022 Elevated MMP10/13 mediated barrier disruption and NF-κB activation aggravate colitis and colon tumorigenesis in both individual or full miR-148/152 family knockout mice. Cancer letters 27 34979166
2020 MMP-10 is Increased in Early Stage Diabetic Kidney Disease and can be Reduced by Renin-Angiotensin System Blockade. Scientific reports 26 31913319
2022 Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10. The Journal of biological chemistry 25 35101440
2014 Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25 25414484
2018 MMP10 Promotes Efficient Thrombolysis After Ischemic Stroke in Mice with Induced Diabetes. Translational stroke research 23 30051168
2023 Role of miR-944/MMP10/AXL- axis in lymph node metastasis in tongue cancer. Communications biology 20 36650344
2020 Increased expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and MMP10, MMP23 in inflammatory bowel disease: Cross-sectional study. Scandinavian journal of immunology 20 32853407
2020 Gentiopicroside ameliorates ethanol-induced gastritis via regulating MMP-10 and pERK1/2 signaling. International immunopharmacology 20 33296781
2019 Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression. Protoplasma 20 31428857
2009 MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer. Experimental dermatology 20 19601983
2017 MMP-10, MMP-7, TIMP-1 and TIMP-2 mRNA expression in esophageal cancer. Acta biochimica Polonica 19 28510611
2011 Type-specific dysregulation of matrix metalloproteinases and their tissue inhibitors in end-stage heart failure patients: relationship between MMP-10 and LV remodelling. Journal of cellular and molecular medicine 19 20219015
2009 Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in Merkel cell carcinoma. Virchows Archiv : an international journal of pathology 18 19921252
2007 Expression of MMP-10 in lung cancer. Anticancer research 18 17695449
2005 Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Biochemical and biophysical research communications 18 16054593
1997 cDNA cloning and expression of the gene encoding murine stromelysin-2 (MMP-10). Gene 18 9427548
2023 MMP10 alleviates non-alcoholic steatohepatitis by regulating macrophage M2 polarization. International immunopharmacology 17 37844469
2011 CRP promotes MMP-10 expression via c-Raf/MEK/ERK and JAK1/ERK pathways in cardiomyocytes. Cellular signalling 17 22142512
2009 Stromelysin-2 (MMP-10) deficiency does not affect adipose tissue formation in a mouse model of nutritionally induced obesity. Biochemical and biophysical research communications 16 19732744
2019 MMP2 and MMP10 Polymorphisms Are Related to Steroid-Induced Osteonecrosis of the Femoral Head among Chinese Han Population. BioMed research international 15 31192258
2017 New thrombolytic strategy providing neuroprotection in experimental ischemic stroke: MMP10 alone or in combination with tissue-type plasminogen activator. Cardiovascular research 15 28379489
2017 Genetic Association of MMP10, MMP14, and MMP16 with Dental Caries. International journal of dentistry 14 28348596
2019 Novel specific human and mouse stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) antibodies for biochemical and immunohistochemical analyses. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 13 30761682
2020 Matrix Metalloproteinase Genes (MMP1, MMP10, MMP12) on Chromosome 11q22 and the Risk of Non-Contact Anterior Cruciate Ligament Ruptures. Genes 11 32650441
2017 Characterization of the early molecular changes in the glomeruli of Cd151 -/- mice highlights induction of mindin and MMP-10. Scientific reports 11 29167507
2021 Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 10 34173256
2018 Macrophage MMP10 Regulates TLR7-Mediated Tolerance. Frontiers in immunology 10 30564235
2022 MMP-10 Deficiency Effects Differentiation and Death of Chondrocytes Associated with Endochondral Osteogenesis in an Endemic Osteoarthritis. Cartilage 9 35818290
2021 miR-496/MMP10 Is Involved in the Proliferation of IL-1β-Induced Fibroblast-Like Synoviocytes Via Mediating the NF-κB Signaling Pathway. Inflammation 9 33548006
2009 Aldose reductase inhibitor counteracts the attenuated adhesion of human corneal epithelial cells induced by high glucose through modulation of MMP-10 expression. Diabetes research and clinical practice 9 19682763
2021 Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma. Journal of clinical medicine 8 34441979
2016 Differential immunohistochemical expression of matrix metalloproteinase-10 (MMP-10) in non-melanoma skin cancers of the head and neck. Pathology, research and practice 8 27567711
2022 Elevated expression of ISY1, APOA-1, SYNE1, MTG1, and MMP10 at HCC initiation: HCC specific protein network involving interactions of key regulators of lipid metabolism, EGFR signaling, MAPK, and splicing pathways. Protoplasma 7 35962262
2021 The Bone Regeneration Capacity of BMP-2 + MMP-10 Loaded Scaffolds Depends on the Tissue Status. Pharmaceutics 7 34209593
2022 Association between Circulating Levels of 25-Hydroxyvitamin D3 and Matrix Metalloproteinase-10 (MMP-10) in Patients with Type 2 Diabetes. Nutrients 6 36079742
2017 Stromelysin-2 (MMP-10) facilitates clearance and moderates inflammation and cell death following lung exposure to long multiwalled carbon nanotubes. International journal of nanomedicine 6 28223796
2011 β1 integrin regulates MMP-10 dependant tubulogenesis in human lymphatic endothelial cells. Matrix biology : journal of the International Society for Matrix Biology 6 21406228
2024 Hepatocyte growth factor upregulates MMP1 and MMP10 expression and resolves corneal fibrosis. Scientific reports 5 39488561
2023 Radiosensitivity in Non-Small-Cell Lung Cancer by MMP10 through the DNA Damage Repair Pathway. Journal of oncology 5 36908704
2019 MMP-10 and TIMP-1 as indicators of severe sepsis in adult hematological patients with febrile neutropenia. Leukemia & lymphoma 5 31122146
2011 Regulation of MMP10 expression by the transcription factor CHF1/Hey2 is mediated by multiple E boxes. Biochemical and biophysical research communications 5 22079635
2022 Computational study revealed a "pull-push" radical transfer mechanism of Mmp10-catalyzed C-methylation of arginine. Chemical communications (Cambridge, England) 4 35666280
2011 Evaluation of MMP-1, MMP-10, TIMP-1, a-SMA and TGF-b1 in angiofibromas of tuberous sclerosis. Minerva stomatologica 4 21252847
2024 NADPH Oxidase 5 (NOX5) Upregulates MMP-10 Production and Cell Migration in Human Endothelial Cells. Antioxidants (Basel, Switzerland) 3 39456453
2023 Role of MMP1 and MMP10 in local invasion and distant metastasis in different levels of oral squamous cell carcinoma - A immunohistochemical comparative study. Journal of oral and maxillofacial pathology : JOMFP 3 37854907
2020 Ski Is Required for Tri-Methylation of H3K9 in Major Satellite and for Repression of Pericentromeric Genes: Mmp3, Mmp10 and Mmp13, in Mouse Fibroblasts. Journal of molecular biology 3 32198114
2023 Profibrotic role of the SOX9-MMP10-ECM biosynthesis axis in the tracheal fibrosis after injury and repair. Genes & diseases 2 38993791
2022 Higher Content but Not Activity of Stromelysin-2 (MMP-10) in Comparison to Stromelysin-1 (MMP-3) in Human Renal Carcinoma. International journal of environmental research and public health 2 36231910
2021 MMP-10 rs17435959 Polymorphism is Associated with the Formation and Stability of Carotid Atherosclerosis Plaque: A Case-Control Study. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2 34418671
2009 Molecular characterization, mapping, and haplotype analysis of porcine matrix metalloproteinase genes MMP1 and MMP10. Biochemical genetics 2 19639408
2025 Endothelial TRIM35-Regulated MMP10 Release Exacerbates Calcification of Vascular Grafts. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 1 39865905
2025 Metformin Inhibits the Development of Helicobacter pylori-Associated Gastritis by Regulating the ERK-MMP10-IL-1β Axis. Cell biochemistry and biophysics 1 40180700
2025 Role of Matrilysins (MMP-7, MMP-26) and Stromelysins (MMP-3, MMP-10) in Diagnosing Cervical Cancer Patients. Biomedicines 1 41462922
2026 Targeting PLK1 Reduces MMP10 to Enhance Radiosensitivity in HPV- Head and Neck Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 0 41252565
2026 Analysis of paired primary-metastatic renal cancer lesions reveals RCN3-MMP10 axis facilitates lung metastasis. Cellular signalling 0 41966439
2025 Matrix metalloproteinase (MMP)-10 aggravates podocyte injury in glomerulonephritis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 0 40328459
2024 Identification of a functional missense variant in the matrix metallopeptidase 10 (MMP10) gene in two families with premature myocardial infarction. Scientific reports 0 38806571

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