- Length
- 439 aa
- Mass
- 52.0 kDa
- Annotated
- 2026-06-10
100 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 100 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 1997 | Transcriptional regulation by cyclic AMP. | Annual review of biochemistry | 805 | 9242925 |
| 1986 | A cyclic AMP- and phorbol ester-inducible DNA element. | Nature | 724 | 3020428 |
| 2007 | Resveratrol stimulates AMP kinase activity in neurons. | Proceedings of the National Academy of Sciences of the United States of America | 619 | 17438283 |
| 1984 | Cyclic AMP receptor protein: role in transcription activation. | Science (New York, N.Y.) | 571 | 6372090 |
| 2007 | Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. | The Biochemical journal | 524 | 17147517 |
| 2000 | Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. | The Biochemical journal | 489 | 10698692 |
| 2007 | Structural basis for AMP binding to mammalian AMP-activated protein kinase. | Nature | 479 | 17851531 |
| 2000 | The regulation of AMP-activated protein kinase by phosphorylation. | The Biochemical journal | 478 | 10642499 |
| 2019 | Cyclic GMP-AMP signalling protects bacteria against viral infection. | Nature | 455 | 31533127 |
| 1992 | Cyclic AMP in prokaryotes. | Microbiological reviews | 434 | 1315922 |
| 2013 | AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation. | Cell metabolism | 412 | 24093679 |
| 2003 | AMP-activated protein kinase, super metabolic regulator. | Biochemical Society transactions | 402 | 12546677 |
| 2012 | The cyclic AMP pathway. | Cold Spring Harbor perspectives in biology | 384 | 23209152 |
| 2006 | Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. | The Journal of biological chemistry | 381 | 16943194 |
| 1998 | AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. | The Biochemical journal | 380 | 9693118 |
| 1995 | 5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. | The Journal of biological chemistry | 365 | 7592975 |
| 2000 | Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor. | Biochemical and biophysical research communications | 300 | 10623586 |
| 2013 | Cyclic di-AMP: another second messenger enters the fray. | Nature reviews. Microbiology | 297 | 23812326 |
| 1974 | Activation of protein kinase by physiological concentrations of cyclic AMP. | Proceedings of the National Academy of Sciences of the United States of America | 280 | 4372627 |
| 1997 | Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription. | Journal of immunology (Baltimore, Md. : 1950) | 266 | 9548485 |
| 2007 | Regulating gene transcription in response to cyclic AMP elevation. | Cellular signalling | 261 | 17993258 |
| 2003 | Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis In 3T3-L1 adipocytes. | The Journal of biological chemistry | 243 | 12941946 |
| 1988 | From epinephrine to cyclic AMP. | Science (New York, N.Y.) | 238 | 2841758 |
| 1998 | Cyclic AMP signaling and gene regulation. | Annual review of nutrition | 209 | 9706229 |
| 2003 | Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. | The Journal of biological chemistry | 204 | 12730239 |
| 2010 | Metformin activates AMP kinase through inhibition of AMP deaminase. | The Journal of biological chemistry | 195 | 21059655 |
| 2000 | Transcriptional regulation by cyclic AMP-responsive factors. | Progress in nucleic acid research and molecular biology | 193 | 10697414 |
| 2002 | AMP-activated kinase regulates cytoplasmic HuR. | Molecular and cellular biology | 187 | 11971974 |
| 2008 | Regulation of erythrocyte survival by AMP-activated protein kinase. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 182 | 19050047 |
| 2004 | Acetyl-coenzyme A synthetase (AMP forming). | Cellular and molecular life sciences : CMLS | 179 | 15316652 |
| 2016 | Copper regulates cyclic-AMP-dependent lipolysis. | Nature chemical biology | 178 | 27272565 |
| 2011 | c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis. | EMBO reports | 173 | 21566650 |
| 2001 | Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1. | The Journal of biological chemistry | 167 | 11278269 |
| 2005 | AMP-activated protein kinase: balancing the scales. | Biochimie | 165 | 15733742 |
| 1990 | Cyclic AMP and mechanisms of vasodilation. | Pharmacology & therapeutics | 164 | 1963221 |
| 2012 | Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver. | PloS one | 159 | 23152807 |
| 1980 | Insulin trigger, cyclic AMP-dependent activation and phosphorylation of a plasma membrane cyclic AMP phosphodiesterase. | Nature | 148 | 6251375 |
| 2009 | AMP-activated protein kinase and cancer. | Acta physiologica (Oxford, England) | 145 | 19243571 |
| 2015 | Cyclic di-AMP mediates biofilm formation. | Molecular microbiology | 131 | 26564551 |
| 1995 | The cyclic AMP system and Drosophila learning. | Molecular and cellular biochemistry | 125 | 8569740 |
| 2010 | Cyclic AMP-mediated cyst expansion. | Biochimica et biophysica acta | 124 | 21118718 |
| 1996 | Role of cyclic AMP in the actions of cannabinoid receptors. | Biochemical pharmacology | 122 | 8781498 |
| 2013 | Cyclic di-AMP impairs potassium uptake mediated by a cyclic di-AMP binding protein in Streptococcus pneumoniae. | Journal of bacteriology | 120 | 24272783 |
| 2018 | AMP kinase promotes glioblastoma bioenergetics and tumour growth. | Nature cell biology | 118 | 29915361 |
| 2014 | AMPK: a cellular energy sensor primarily regulated by AMP. | Biochemical Society transactions | 118 | 24450630 |
| 1995 | Cyclic AMP-dependent activation of Rap1b. | The Journal of biological chemistry | 118 | 7737967 |
| 2012 | AMP is an adenosine A1 receptor agonist. | The Journal of biological chemistry | 112 | 22215671 |
| 1998 | Cyclic AMP, PKA, and the physiological regulation of adiposity. | Recent progress in hormone research | 102 | 9769707 |
| 2002 | Reinventing the wheel of cyclic AMP: novel mechanisms of cAMP signaling. | Annals of the New York Academy of Sciences | 100 | 12119267 |
| 2012 | Cyclic AMP dynamics in the pancreatic β-cell. | Upsala journal of medical sciences | 98 | 22970724 |
| 2014 | Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches. | Current opinion in microbiology | 94 | 24509484 |
| 2014 | Cyclic AMP (cAMP) signaling in melanocytes and melanoma. | Archives of biochemistry and biophysics | 94 | 25017568 |
| 2009 | AMP-activated protein kinase--a sensor of glycogen as well as AMP and ATP? | Acta physiologica (Oxford, England) | 94 | 19245651 |
| 2007 | Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. | American journal of physiology. Heart and circulatory physiology | 92 | 17369473 |
| 1999 | Signal transduction involving cyclic AMP-dependent and cyclic AMP-independent mechanisms in the control of steroidogenesis. | Molecular and cellular endocrinology | 92 | 10411317 |
| 1996 | Stimulation of rat liver AMP-activated protein kinase by AMP analogues. | Biochimica et biophysica acta | 90 | 8645724 |
| 2006 | S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase. | Gastroenterology | 89 | 16831604 |
| 2011 | Functional modulation of AMP-activated protein kinase by cereblon. | Biochimica et biophysica acta | 86 | 21232561 |
| 2010 | Cyclic AMP signaling in pancreatic islets. | Advances in experimental medicine and biology | 80 | 20217503 |
| 1982 | Is DNA unwound by the cyclic AMP receptor protein? | Nucleic acids research | 80 | 6278415 |
| 2002 | A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion. | The Biochemical journal | 79 | 12093363 |
| 1985 | Identification and cyclic AMP-induced modification of the cyclic AMP receptor in Dictyostelium discoideum. | The Journal of biological chemistry | 79 | 2981872 |
| 2015 | Inhibition of AMP Kinase by the Protein Phosphatase 2A Heterotrimer, PP2APpp2r2d. | The Journal of biological chemistry | 78 | 25694423 |
| 2009 | Antimicrobial peptides (AMP) with antiviral activity against fish nodavirus. | Fish & shellfish immunology | 77 | 20004246 |
| 2017 | AMP-activated protein kinase - not just an energy sensor. | F1000Research | 76 | 29034085 |
| 2016 | Regulation of IP3 receptors by cyclic AMP. | Cell calcium | 75 | 27836216 |
| 1989 | Cyclic AMP waves during aggregation of Dictyostelium amoebae. | Development (Cambridge, England) | 70 | 2557197 |
| 2005 | Activating AMP-activated protein kinase without AMP. | Molecular cell | 69 | 16061173 |
| 2006 | Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase. | The Journal of biological chemistry | 68 | 16849326 |
| 1996 | Cyclic AMP-independent catabolite repression in bacteria. | FEMS microbiology letters | 68 | 9026456 |
| 1994 | Activation of rat liver AMP-activated protein kinase by kinase kinase in a purified, reconstituted system. Effects of AMP and AMP analogues. | European journal of biochemistry | 68 | 8112325 |
| 2017 | Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity? | The European respiratory journal | 67 | 28179439 |
| 2011 | Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes. | Journal of cellular biochemistry | 67 | 21312243 |
| 2012 | Cyclic AMP underpins suppression by regulatory T cells. | European journal of immunology | 66 | 22678893 |
| 2019 | The Role of Cyclic AMP Signaling in Cardiac Fibrosis. | Cells | 65 | 31888098 |
| 2007 | The role of AMP kinase in diabetes. | The Indian journal of medical research | 62 | 17496363 |
| 1988 | Cyclic AMP-cyclic AMP receptor protein as a repressor of transcription of the spf gene of Escherichia coli. | Journal of bacteriology | 60 | 2454912 |
| 2007 | Regulation of cyclooxygenase-2 expression by cyclic AMP. | Biochimica et biophysica acta | 59 | 17945363 |
| 2002 | Cyclic AMP stimulates renin gene transcription in juxtaglomerular cells. | Pflugers Archiv : European journal of physiology | 58 | 12111241 |
| 1977 | Interaction of AMP-aminohydrolase with myosin and its subfragments. | The Journal of biological chemistry | 58 | 321446 |
| 2007 | AMP does not induce torpor. | American journal of physiology. Regulatory, integrative and comparative physiology | 57 | 17409259 |
| 1994 | Stress relaxation of fibroblasts activates a cyclic AMP signaling pathway. | The Journal of cell biology | 57 | 7518467 |
| 2000 | Cyclic AMP activates Ras. | Oncogene | 55 | 10951566 |
| 2009 | Bacterial FIC Proteins AMP Up Infection. | Science signaling | 53 | 19293428 |
| 1979 | Photoaffinity labeling of cyclic-AMP- and AMP-binding proteins differentiating Dictyostelium discoideum cells. | Proceedings of the National Academy of Sciences of the United States of America | 51 | 228291 |
| 2014 | Gene of the month. AMP kinase (PRKAA1). | Journal of clinical pathology | 50 | 24895169 |
| 1978 | Cyclic AMP-dependent protein kinase mediates a cyclic AMP-stimulated decrease in ornithine and S-adenosylmethionine decarboxylase activities. | Proceedings of the National Academy of Sciences of the United States of America | 50 | 204937 |
| 2008 | Cyclic AMP in rat ileum: evidence for the presence of an extracellular cyclic AMP-adenosine pathway. | Gastroenterology | 49 | 18316082 |
| 2009 | AMP-activated protein kinase inhibits TREK channels. | The Journal of physiology | 48 | 19840997 |
| 2012 | Enzymatic characterization of AMP phosphorylase and ribose-1,5-bisphosphate isomerase functioning in an archaeal AMP metabolic pathway. | Journal of bacteriology | 46 | 23065974 |
| 1999 | Cyclic AMP and arachidonic acid: a tale of two pathways. | Molecular and cellular endocrinology | 46 | 10630400 |
| 1993 | Transcriptional regulation of choline acetyltransferase gene by cyclic AMP. | Journal of neurochemistry | 45 | 8384248 |
| 1991 | The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase. | Biochimica et biophysica acta | 43 | 1655040 |
| 2013 | Cyclic AMP synergizes with butyrate in promoting β-defensin 9 expression in chickens. | Molecular immunology | 42 | 24141182 |
| 1975 | Cyclic AMP and psoriasis. | The Journal of investigative dermatology | 42 | 239070 |
| 2014 | 2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors. | Brain research | 41 | 25451117 |
| 2001 | Uterine quiescence: the role of cyclic AMP. | Experimental physiology | 40 | 11429643 |
| 1998 | Cyclic AMP-elevating agents prevent oligodendroglial excitotoxicity. | Journal of neurochemistry | 40 | 9603206 |
| 2005 | AMP deamination delays muscle acidification during heavy exercise and hypoxia. | The Journal of biological chemistry | 39 | 16314416 |
| 1990 | Cyclic AMP- and Ca2(+)-dependent protein kinases in Plasmodium falciparum. | Experimental parasitology | 39 | 2191871 |
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