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Effects of AMP and AMP analogues.","date":"1994","source":"European journal of biochemistry","url":"https://pubmed.ncbi.nlm.nih.gov/8112325","citation_count":68,"is_preprint":false},{"pmid":"21312243","id":"PMC_21312243","title":"Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes.","date":"2011","source":"Journal of cellular biochemistry","url":"https://pubmed.ncbi.nlm.nih.gov/21312243","citation_count":67,"is_preprint":false},{"pmid":"28179439","id":"PMC_28179439","title":"Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity?","date":"2017","source":"The European respiratory journal","url":"https://pubmed.ncbi.nlm.nih.gov/28179439","citation_count":67,"is_preprint":false},{"pmid":"22678893","id":"PMC_22678893","title":"Cyclic AMP underpins suppression by regulatory T cells.","date":"2012","source":"European journal of immunology","url":"https://pubmed.ncbi.nlm.nih.gov/22678893","citation_count":66,"is_preprint":false},{"pmid":"31888098","id":"PMC_31888098","title":"The Role of Cyclic AMP Signaling in Cardiac Fibrosis.","date":"2019","source":"Cells","url":"https://pubmed.ncbi.nlm.nih.gov/31888098","citation_count":65,"is_preprint":false},{"pmid":"17496363","id":"PMC_17496363","title":"The role of AMP kinase in diabetes.","date":"2007","source":"The Indian journal of medical research","url":"https://pubmed.ncbi.nlm.nih.gov/17496363","citation_count":62,"is_preprint":false},{"pmid":"2454912","id":"PMC_2454912","title":"Cyclic AMP-cyclic AMP receptor protein as a repressor of transcription of the spf gene of Escherichia coli.","date":"1988","source":"Journal of bacteriology","url":"https://pubmed.ncbi.nlm.nih.gov/2454912","citation_count":60,"is_preprint":false},{"pmid":"17945363","id":"PMC_17945363","title":"Regulation of cyclooxygenase-2 expression by cyclic AMP.","date":"2007","source":"Biochimica et biophysica acta","url":"https://pubmed.ncbi.nlm.nih.gov/17945363","citation_count":59,"is_preprint":false},{"pmid":"321446","id":"PMC_321446","title":"Interaction of AMP-aminohydrolase with myosin and its subfragments.","date":"1977","source":"The Journal of biological chemistry","url":"https://pubmed.ncbi.nlm.nih.gov/321446","citation_count":58,"is_preprint":false},{"pmid":"12111241","id":"PMC_12111241","title":"Cyclic AMP stimulates renin gene transcription in juxtaglomerular cells.","date":"2002","source":"Pflugers Archiv : European journal of physiology","url":"https://pubmed.ncbi.nlm.nih.gov/12111241","citation_count":58,"is_preprint":false},{"pmid":"17409259","id":"PMC_17409259","title":"AMP does not induce torpor.","date":"2007","source":"American journal of physiology. 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AMP kinase (PRKAA1).","date":"2014","source":"Journal of clinical pathology","url":"https://pubmed.ncbi.nlm.nih.gov/24895169","citation_count":50,"is_preprint":false},{"pmid":"204937","id":"PMC_204937","title":"Cyclic AMP-dependent protein kinase mediates a cyclic AMP-stimulated decrease in ornithine and S-adenosylmethionine decarboxylase activities.","date":"1978","source":"Proceedings of the National Academy of Sciences of the United States of America","url":"https://pubmed.ncbi.nlm.nih.gov/204937","citation_count":50,"is_preprint":false},{"pmid":"18316082","id":"PMC_18316082","title":"Cyclic AMP in rat ileum: evidence for the presence of an extracellular cyclic AMP-adenosine pathway.","date":"2008","source":"Gastroenterology","url":"https://pubmed.ncbi.nlm.nih.gov/18316082","citation_count":49,"is_preprint":false},{"pmid":"19840997","id":"PMC_19840997","title":"AMP-activated protein kinase inhibits TREK channels.","date":"2009","source":"The Journal of physiology","url":"https://pubmed.ncbi.nlm.nih.gov/19840997","citation_count":48,"is_preprint":false},{"pmid":"10630400","id":"PMC_10630400","title":"Cyclic AMP and arachidonic acid: a tale of two pathways.","date":"1999","source":"Molecular and cellular endocrinology","url":"https://pubmed.ncbi.nlm.nih.gov/10630400","citation_count":46,"is_preprint":false},{"pmid":"23065974","id":"PMC_23065974","title":"Enzymatic characterization of AMP phosphorylase and ribose-1,5-bisphosphate isomerase functioning in an archaeal AMP metabolic pathway.","date":"2012","source":"Journal of bacteriology","url":"https://pubmed.ncbi.nlm.nih.gov/23065974","citation_count":46,"is_preprint":false},{"pmid":"8384248","id":"PMC_8384248","title":"Transcriptional regulation of choline acetyltransferase gene by cyclic AMP.","date":"1993","source":"Journal of neurochemistry","url":"https://pubmed.ncbi.nlm.nih.gov/8384248","citation_count":45,"is_preprint":false},{"pmid":"1655040","id":"PMC_1655040","title":"The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase.","date":"1991","source":"Biochimica et biophysica acta","url":"https://pubmed.ncbi.nlm.nih.gov/1655040","citation_count":43,"is_preprint":false},{"pmid":"239070","id":"PMC_239070","title":"Cyclic AMP and psoriasis.","date":"1975","source":"The Journal of investigative dermatology","url":"https://pubmed.ncbi.nlm.nih.gov/239070","citation_count":42,"is_preprint":false},{"pmid":"24141182","id":"PMC_24141182","title":"Cyclic AMP synergizes with butyrate in promoting β-defensin 9 expression in chickens.","date":"2013","source":"Molecular immunology","url":"https://pubmed.ncbi.nlm.nih.gov/24141182","citation_count":42,"is_preprint":false},{"pmid":"25451117","id":"PMC_25451117","title":"2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors.","date":"2014","source":"Brain research","url":"https://pubmed.ncbi.nlm.nih.gov/25451117","citation_count":41,"is_preprint":false},{"pmid":"11429643","id":"PMC_11429643","title":"Uterine quiescence: the role of cyclic AMP.","date":"2001","source":"Experimental physiology","url":"https://pubmed.ncbi.nlm.nih.gov/11429643","citation_count":40,"is_preprint":false},{"pmid":"9603206","id":"PMC_9603206","title":"Cyclic AMP-elevating agents prevent oligodendroglial excitotoxicity.","date":"1998","source":"Journal of neurochemistry","url":"https://pubmed.ncbi.nlm.nih.gov/9603206","citation_count":40,"is_preprint":false},{"pmid":"2191871","id":"PMC_2191871","title":"Cyclic AMP- and Ca2(+)-dependent protein kinases in Plasmodium falciparum.","date":"1990","source":"Experimental parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/2191871","citation_count":39,"is_preprint":false},{"pmid":"16314416","id":"PMC_16314416","title":"AMP deamination delays muscle acidification during heavy exercise and hypoxia.","date":"2005","source":"The Journal of biological chemistry","url":"https://pubmed.ncbi.nlm.nih.gov/16314416","citation_count":39,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":43897,"output_tokens":320,"usd":0.068246,"stage1_stop_reason":"end_turn"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.068246,"stage1_batch_id":"msgbatch_01BbTCMyrRPyhtEq6b1MdwCN","stage2_batch_id":"msgbatch_011dEed5bbxYvTAaQWKJevxu","note":"batch pricing = 50% of standard"},"stage1_raw":"Looking through these 100 papers, I need to identify which ones are actually about the human gene MFAP1 (also known as AMP, based on the HGNC aliases provided).\n\nAfter careful review, none of these papers appear to be about the canonical MFAP1 protein (Microfibrillar-Associated Protein 1). The alias \"AMP\" here causes a massive collision — all 100 retrieved papers are about completely different topics: cyclic AMP (cAMP) signaling, AMP-activated protein kinase (AMPK), adenosine monophosphate biochemistry, bacterial cyclic di-AMP, antimicrobial peptides, etc. None describe the MFAP1/AMP protein that is a component of the spliceosome/pre-mRNA processing machinery.\n\nNone of these papers pass the on-target filter for MFAP1 (the microfibrillar-associated protein 1 involved in pre-mRNA splicing). They are all alias collisions or completely unrelated proteins/pathways.\n\n```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings about MFAP1 (Microfibrillar-Associated Protein 1) were present in the available literature corpus; all retrieved papers represent alias collisions with unrelated AMP/cAMP/AMPK biology.\"\n}\n```","stage2_raw":"","audit_flag":{"gene":"MFAP1","tier":"GROUNDING","verdict":"Evidence-grounding concern","subtype":"recall_miss","uniprot_band":"sparse","rules_fired":"R5","issue":"R5: no narrative despite experimental UniProt FUNCTION (63 chars) and on-target evidence in corpus (100 on-target corpus titles)"},"evaluation":null}