Affinage

MED13

Mediator of RNA polymerase II transcription subunit 13 · UniProt Q9UHV7

Length
2174 aa
Mass
239.3 kDa
Annotated
2026-06-10
35 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MED13 is the scaffold subunit that physically tethers the CDK8 kinase module (CKM)—comprising CDK8/cyclin C and MED12—to core Mediator, thereby acting as a master switch over RNA Polymerase II transcription [PMID:bio_10.1101_2024.07.01.601608, PMID:23322298, PMID:12738880]. Cryo-EM of the complete human Mediator shows MED13 docking the CKM onto core Mediator through an intrinsically disordered region (IDR), with that IDR occluding RNA Pol II and MED26 binding and sterically blocking pre-initiation complex assembly, providing the structural basis for transcriptional inhibition [PMID:bio_10.1101_2024.07.01.601608]; consistently, the yeast TRAP240/MED13-containing submodule is found only on Mediator that is free of Pol II (PMID:12738880). Because MED13 abundance dictates how much CKM associates with Mediator, its level is tightly controlled by SCF-Fbw7-directed ubiquitin-proteasomal degradation in mammals (PMID:23322298), and in yeast by SCFGrr1 acting on cyclin C-Cdk8-primed and Snf1/Slt2-modified degrons within the IDR, which releases cyclin C to drive mitochondrial fragmentation and cell death under oxidative stress (PMID:29212878, PMID:30175106). Beyond transcription, stress-induced MED13 translocates from nucleus to cytoplasm where it promotes P-body assembly and the selective autophagic degradation of the decapping activator Edc3 via the receptor Ksp1 and Snx4-assisted autophagy (PMID:39320938, PMID:37733395). As a context-specific transcriptional regulator, MED13 represses target programs in distinct tissues: it suppresses thyroid-hormone-receptor genes in the heart while controlling systemic energy homeostasis through a circulating humoral signal to adipose and liver (PMID:25422356, PMID:30769017), represses muscle glucose-uptake genes through inhibition of NURR1 and MEF2 (PMID:26883362), and directly binds CCND1 regulatory elements to restrain cyclin D1 and G1 progression (PMID:33444446). In development, MED13 acts with MED12 to transmit specific differentiation signals (PMID:11171343), partners with Pygopus to activate Wnt/Wingless targets (PMID:18451032), is required for zygotic genome activation via E2F interactions (PMID:29325037), and controls cortical neuronal radial migration and callosal projection at least partly through PLXNA4 (PMID:41663567).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2001 Medium

    Establishing that MED13 is not a generic Mediator subunit but a transmitter of specific developmental signals, since it phenocopies MED12 loss and acts independently of Hedgehog/Notch.

    Evidence Clonal loss-of-function and pathway-epistasis with cell-fate marker staining in Drosophila imaginal discs

    PMID:11171343

    Open questions at the time
    • Direct biochemical target of the Med12/Med13 module not identified
    • Mechanism of signal specificity unresolved
  2. 2003 High

    Defining the negative-regulatory logic of the MED13-containing module by showing it occupies Mediator only when Pol II is absent.

    Evidence Biochemical fractionation and co-purification with Pol II association assays in S. pombe

    PMID:12738880

    Open questions at the time
    • Structural basis of Pol II exclusion not resolved at this stage
    • Did not address regulation of module abundance
  3. 2008 High

    Showing MED13 can also positively couple a signaling input to transcription, recruiting Mediator to Wnt/Wingless target genes via Pygopus.

    Evidence Genetic epistasis, RNAi, and Co-IP with reporter assays in Drosophila

    PMID:18451032

    Open questions at the time
    • Whether the Pygopus interaction is conserved in mammals untested
    • How activating versus repressive roles are reconciled mechanistically unclear
  4. 2013 High

    Identifying MED13 as the physical linker whose proteolytic turnover, controlled by SCF-Fbw7, sets CKM-Mediator association dynamics.

    Evidence Reciprocal Co-IP, Fbw7 KO, and ubiquitin-ligase substrate/stability assays in mammalian cells

    PMID:23322298

    Open questions at the time
    • Signals upstream of Fbw7 targeting of MED13 not defined
    • Consequences for specific gene programs not mapped
  5. 2014 High

    Revealing a systemic physiological output: cardiac MED13 controls whole-body energy homeostasis through a secreted humoral factor, with a conserved upstream role for Wingless in fly muscle.

    Evidence Cardiac transgenic overexpression plus parabiosis and metabolic phenotyping in mice; tissue-specific RNAi epistasis in Drosophila

    PMID:24979807 PMID:25422356

    Open questions at the time
    • Identity of the circulating humoral factor unknown
    • Transcriptional targets mediating the metabolic effect not fully defined
  6. 2016 High

    Distinguishing a tissue-specific repressor function in skeletal muscle through inhibition of NURR1 and MEF2 to suppress glucose metabolism.

    Evidence Skeletal-muscle conditional KO, RNA-seq, and metabolic phenotyping in mice

    PMID:26883362

    Open questions at the time
    • Direct physical interaction with NURR1/MEF2 not structurally defined
    • Relationship to the cardiac humoral pathway unclear
  7. 2017 High

    Mapping how MED13 destruction is licensed under stress, via a CKM-primed phosphodegron and CWI-MAPK signaling that releases cyclin C to trigger cell death.

    Evidence Degron deletion mapping, phosphorylation and SCFGrr1/Slt2 epistasis, and cyclin C localization imaging in S. cerevisiae

    PMID:29212878

    Open questions at the time
    • Whether an analogous degron operates in mammalian MED13 untested
    • Direct kinase-substrate contacts not biochemically resolved
  8. 2018 Medium

    Extending stress-induced MED13 turnover by identifying a second AMPK/Snf1-activated degron acting cooperatively with the CWI pathway, and uncovering nucleocytoplasmic E2F-linked roles in zygotic genome activation.

    Evidence snf1Δ stability/localization and heterologous degron assays in yeast; siRNA/conditional KO embryos with E2F Co-IP in mouse

    PMID:29325037 PMID:30175106

    Open questions at the time
    • Single-lab findings extending prior model
    • How E2F interaction is integrated with esBAF regulation unresolved
  9. 2019 Medium

    Defining MED13 as a transcriptional repressor in cardiac thyroid hormone signaling.

    Evidence Cardiomyocyte conditional KO with RNA-seq, echocardiography, and PTU/T3 manipulation in mice

    PMID:30769017

    Open questions at the time
    • Direct interaction with thyroid hormone receptor not shown
    • Link to the systemic humoral phenotype unestablished
  10. 2021 Medium

    Showing MED13 directly represses a cell-cycle gene (CCND1) to restrain G1, linking its level to drug sensitivity and CDK8/19 inhibition.

    Evidence Genome-wide CRISPR screen, MED13 KO, ChIP at CCND1 elements, and Senexin A treatment in cancer cells

    PMID:33444446

    Open questions at the time
    • Mechanism by which Senexin A stabilizes MED13 not defined
    • Single-lab study
  11. 2024 Medium

    Establishing a transcription-independent cytoplasmic function for MED13 in P-body assembly and selective autophagic degradation of Edc3 via Ksp1/Atg8 and Snx4-assisted autophagy.

    Evidence Colocalization imaging, Y2H, AIM/LIR and Atg8-LDS mutagenesis, and autophagic degradation assays in S. cerevisiae

    PMID:37733395 PMID:39320938

    Open questions at the time
    • Whether this cytoplasmic role is conserved in metazoans untested
    • How nuclear export of Med13 is triggered mechanistically unclear
  12. 2024 High

    Resolving the structural mechanism of inhibition: the MED13 IDR docks the CKM and sterically occludes Pol II/MED26 and PIC assembly.

    Evidence Cryo-EM of complete human Mediator with functional validation of CKM-cMED interaction (preprint)

    PMID:bio_10.1101_2024.07.01.601608

    Open questions at the time
    • Conformational dynamics during activation not captured
    • How signal-induced MED13 degradation relieves the steric block structurally not shown
  13. 2024 Medium

    Clarifying that MED12/MED13 cooperate locally at enhancers with SAYP/Bap170 independent of the CKM enzymatic subunits, refining where the module acts.

    Evidence Transgene reporters, ChIP at endogenous loci, and negative Co-IP for stable complex in Drosophila

    PMID:39684492

    Open questions at the time
    • Nature of the transient/local interaction not biochemically defined
    • Whether this mode is conserved unknown
  14. 2026 Medium

    Connecting MED13 to neurodevelopmental phenotypes by placing it upstream of PLXNA4 in cortical migration and projection.

    Evidence In-utero electroporation knockdown with imaging, MS proteomics, and PlxnA4 rescue in mice/SH-SY5Y cells

    PMID:41663567

    Open questions at the time
    • Whether MED13 transcriptionally controls PLXNA4 directly not shown
    • Dendritic complexity defect not rescued, indicating additional targets

Open questions

Synthesis pass · forward-looking unresolved questions
  • Whether the stress-triggered nuclear export, P-body, and autophagy functions of MED13 documented in yeast operate in mammalian cells, and how MED13 turnover dynamically converts its repressive structural role into context-specific gene programs, remains unresolved.
  • No mammalian validation of cytoplasmic/P-body function
  • Integration of structural inhibition with tissue-specific repression not mechanistically connected

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 4 GO:0098772 molecular function regulator activity 3 GO:0005198 structural molecule activity 2 GO:0003677 DNA binding 1
Localization
GO:0005634 nucleus 2 GO:0005829 cytosol 1
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1430728 Metabolism 2 R-HSA-9612973 Autophagy 2 R-HSA-1640170 Cell Cycle 1
Partners
CDK8CYCLIN CE2FEDC3FBW7KSP1MED12PYGOPUS
Complex memberships
CDK8 kinase module (CKM)Mediator complex

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2024 Cryo-EM structure of the human complete Mediator complex reveals that the CKM binds to core Mediator (cMED) through an intrinsically disordered region (IDR) in MED13 and HEAT repeats in MED12. The MED13 IDR occludes binding of RNA Polymerase II and MED26 to cMED and sterically hinders cMED-PIC assembly with TFIIH and the +1 nucleosome, thereby inhibiting transcription activation. Cryo-electron microscopy structural determination with functional validation of CKM-cMED interaction and transcription inhibition mechanism bioRxivpreprint High bio_10.1101_2024.07.01.601608
2013 Fbw7, a tumor suppressor and SCF ubiquitin ligase, binds CDK8-Mediator and targets MED13 (and MED13L) for proteasomal degradation. MED13/13L physically link the CDK8 module to Mediator; loss of Fbw7 increases CDK8 module-Mediator association, revealing MED13 as a physical linker whose abundance controls CDK8 module-Mediator dynamics. Co-immunoprecipitation, ubiquitin ligase substrate assay, genetic loss-of-function (Fbw7 KO), protein stability assays Genes & development High 23322298
2003 In S. pombe, spTrap240 (TRAP240/MED13 homolog) is stably associated with a larger Mediator form also containing Srb8, Srb10, and Srb11 subunits. Mediator containing this module is isolated only free of RNA Polymerase II, whereas Mediator lacking this module associates with the polymerase, establishing that the TRAP240/MED13-containing submodule negatively regulates transcription by preventing Mediator-Pol II association. Biochemical fractionation, co-purification, genetic phenotypic analysis, transcriptional profiling Proceedings of the National Academy of Sciences of the United States of America High 12738880
2008 In Drosophila, Med13 (encoded by skuld) physically interacts with Pygopus through its N-terminal domain and is required for transcription of Wingless target genes downstream of beta-catenin stabilization, establishing Med13 as a mediator of Wnt/Wingless target gene activation by recruiting the Mediator complex. Genetic epistasis (in vivo), RNAi knockdown in cell culture, co-immunoprecipitation (physical interaction with Pygopus), reporter assays Proceedings of the National Academy of Sciences of the United States of America High 18451032
2017 In S. cerevisiae, oxidative stress triggers SCFGrr1-dependent ubiquitin-mediated degradation of Med13 via a degron in residues 742-844 of its intrinsically disordered region (IDR). Cyclin C-Cdk8 phosphorylation of Med13 primes this phosphodegron, and the CWI MAPK Slt2 phosphorylates cyclin C to release it from Med13 and subsequently modifies Med13 to stimulate SCFGrr1-mediated destruction, thereby releasing cyclin C into the cytoplasm to promote mitochondrial hyperfragmentation and cell death. Deletion mutagenesis mapping of degron, in vivo phosphorylation assays, genetic epistasis with SCFGrr1/Slt2 mutants, fluorescence microscopy of cyclin C localization, mitochondrial fragmentation assay Molecular biology of the cell High 29212878
2018 In S. cerevisiae, the AMP kinase Snf1 activates a second SCFGrr1-responsive degron in Med13 following oxidative stress. Deletion of Snf1 results in nuclear retention of cyclin C and failure to induce mitochondrial fragmentation, defining a second pathway (CWI MAPK pathway and Snf1 together) that cooperatively controls Med13 degradation and cyclin C release. Genetic deletion (snf1Δ), in vivo protein stability assays, fluorescence microscopy of cyclin C localization, heterologous degron fusion assay, mitochondrial fragmentation assay Microbial cell Medium 30175106
2014 Cardiac-specific overexpression of MED13 in transgenic mice confers a lean phenotype associated with increased lipid uptake, beta-oxidation, and mitochondrial content in white adipose tissue and liver. Parabiosis experiments reveal that circulating factor(s) from MED13cTg mice promote enhanced metabolism in wild-type partners, establishing that cardiac MED13 acts within the heart to regulate systemic energy homeostasis through a humoral signaling mechanism. Cardiac-specific transgenic overexpression, parabiosis experiments, metabolic phenotyping (indirect calorimetry, beta-oxidation assays), gene expression analysis EMBO molecular medicine High 25422356
2014 In Drosophila, heart/muscle-specific knockdown of MED13 increases susceptibility to obesity. Genetic epistasis experiments demonstrate that Wingless functions downstream of MED13 within a muscle-regulatory pathway controlling systemic energy homeostasis, establishing MED13 as an upstream regulator of Wingless signaling in striated muscle to control fat storage. Tissue-specific RNAi knockdown, RNAi genetic screen of 150 secreted protein genes, epistasis experiments (double knockdown), metabolic phenotyping (lipid storage) Proceedings of the National Academy of Sciences of the United States of America Medium 24979807
2016 Skeletal muscle-specific deletion of MED13 in mice activates a metabolic gene program enhancing muscle glucose uptake and glycogen storage, insulin-sensitizes skeletal muscle, and prevents hepatic lipid accumulation. MED13 suppresses glucose metabolism genes in skeletal muscle by inhibiting the nuclear receptor NURR1 and MEF2 transcription factor, revealing a tissue-specific transcriptional repressor function of MED13 distinct from its cardiac role. Skeletal muscle-specific conditional knockout (Cre-lox), RNA-seq gene expression profiling, metabolic phenotyping (glucose uptake, glycogen measurement, hepatic lipid staining), transcription factor interaction analysis Genes & development High 26883362
2018 MED13 is required for zygotic genome activation (ZGA) in mouse embryos and regulates expression of the embryo-specific chromatin remodeling complex esBAF. MED13's role in ZGA is mediated in part through interactions with E2F transcription factors. MED13's paralog MED13L partially compensates for MED13 loss during preimplantation but cannot rescue postimplantation development. siRNA knockdown, conditional knockout, embryo culture with developmental phenotyping, gene expression analysis, co-immunoprecipitation with E2F transcription factors Biology of reproduction Medium 29325037
2021 Loss of MED13 causes resistance to alkylating agents by upregulating cyclin D1 (CCND1). MED13 directly binds to CCND1 regulatory elements to suppress its expression, and MED13 KO cells have a shorter G1 phase. CDK8/19 inhibitor Senexin A stabilizes MED13 protein and in combination with alkylating agents reduces cancer cell viability. Genome-wide CRISPR-Cas9 screen, MED13 KO, transcriptome analysis, ChIP (MED13 binding to CCND1 regulatory elements), cell viability assays, CDK8/19 inhibitor treatment Nucleic acids research Medium 33444446
2024 In S. cerevisiae, Med13 translocates from the nucleus to the cytoplasm following nitrogen starvation, where it colocalizes with P-bodies and promotes recruitment of the decapping activator Edc3 into P-bodies. Med13 also orchestrates the autophagic degradation of Edc3 through a selective cargo-hitchhiking autophagy pathway using Ksp1 as the autophagic receptor protein, revealing a transcription-independent cytoplasmic function of Med13 in P-body assembly and mRNA regulation. Fluorescence microscopy (colocalization of Med13 with P-body markers), deletion mutant analysis, autophagic degradation assays, genetic epistasis Molecular biology of the cell Medium 39320938
2024 In S. cerevisiae, Ksp1 (a casein II-like kinase) acts as an autophagic receptor protein for Ssn2/Med13, mediating its selective vacuolar degradation via Snx4-assisted autophagy following nitrogen starvation. Ksp1 directly associates with Atg8 through an AIM/LIR motif, and mutating the LDS site in Atg8 prevents Ksp1 autophagic degradation. Ksp1 is recruited early to phagophore assembly sites by Atg29. Yeast two-hybrid, mutational analysis of AIM/LIR and LDS sites, fluorescence microscopy of phagophore assembly sites, autophagic degradation assays, genetic epistasis Autophagy Medium 37733395
2001 Loss of the Drosophila Med13 homolog (kohtalo/skuld) causes eye disc cells to maintain inappropriate expression of decapentaplegic and atonal and fail to differentiate, while antennal disc cells lose Distal-less expression. These phenotypes are identical to those of Med12 (blind spot) loss, are not rescued by activation of Hedgehog or Notch pathways, and occur without loss of cell proliferation or survival, indicating Med12 and Med13 act together to mediate a specific developmental signal. Genetic loss-of-function (mutant clonal analysis), epistasis with Hedgehog and Notch pathway activation, immunostaining for cell fate markers Development Medium 11171343
2019 Med13 represses thyroid hormone receptor (TR) response genes in the heart. Cardiomyocyte-specific deletion of Med13 exacerbates cardiac dysfunction in hypothyroid mice (PTU-treated), and unbiased RNA-seq defined TH-dependent gene expression changes regulated by Med13, establishing Med13 as a transcriptional repressor in the cardiac thyroid hormone signaling pathway. Cardiomyocyte-specific conditional knockout (Med13cKO), RNA-seq transcriptome analysis, echocardiography, PTU-induced hypothyroidism model, T3 rescue experiment Journal of molecular and cellular cardiology Medium 30769017
2024 In Drosophila, Med13 cooperates with Med12 but not with Cdk8 or CycC (the enzymatic subunits) to support SAYP/Bap170-dependent enhancer-driven transcription at transgene promoters and endogenous loci. Med12 and Med13 do not form sufficiently stable interactions with SAYP/Bap170 in extract; their cooperation is local at regulatory elements, with SAYP/Bap170 presence required for stable recruitment of Med12/Med13 to loci. Transgene reporter assays, genetic knockdown/mutants, ChIP at endogenous loci, co-immunoprecipitation attempts (negative for stable complex) International journal of molecular sciences Medium 39684492
2026 Knockdown of Med13 in cortical neurons via in-utero electroporation impairs radial migration, callosal (contralateral) projection, and dendritic complexity. Mass spectrometry of MED13-deleted SH-SY5Y cells identified PLXNA4 as a downstream dysregulated protein; overexpression of PlxnA4 rescues impaired radial migration and callosal projection (but not dendritic complexity) in Med13-knockdown neurons, placing Med13 upstream of PlxnA4 in cortical development. In-utero electroporation knockdown, immunofluorescence/confocal imaging, mass spectrometry proteomics, rescue overexpression of PlxnA4 Communications biology Medium 41663567
2022 In Drosophila, Skd/Med13 and glycolytic enzymes are co-upregulated in response to alpha-synuclein-associated neurodegeneration. Co-expression of skd/Med13 RNAi with alpha-synuclein synergistically increases the ratio of oxidized-to-reduced glutathione, worsening neurodegeneration. This neurodegeneration can be suppressed by overexpression of a glycolytic enzyme or treatment with deferoxamine, and the functional relationship between alpha-synuclein, MED13, and glycolytic enzymes is conserved in mice. Drosophila genetic screen (3471 mutant chromosomes), RNAi co-expression, glutathione oxidation assay, pharmacological rescue (deferoxamine), cross-species validation in mice Cell reports Medium 36543134

Source papers

Stage 0 corpus · 35 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Missense mutations and gene interruption in PROSIT240, a novel TRAP240-like gene, in patients with congenital heart defect (transposition of the great arteries). Circulation 135 14638541
2008 Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13. Proceedings of the National Academy of Sciences of the United States of America 107 18451032
2013 The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. Genes & development 100 23322298
2003 TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution. Proceedings of the National Academy of Sciences of the United States of America 98 12738880
2001 Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development. Development (Cambridge, England) 96 11171343
2014 MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver. EMBO molecular medicine 85 25422356
2018 De novo mutations in MED13, a component of the Mediator complex, are associated with a novel neurodevelopmental disorder. Human genetics 64 29740699
2014 Heart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila. Proceedings of the National Academy of Sciences of the United States of America 52 24979807
2016 A MED13-dependent skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism. Genes & development 40 26883362
2018 MicroRNA-499-5p regulates skeletal myofiber specification via NFATc1/MEF2C pathway and Thrap1/MEF2C axis. Life sciences 34 30419283
2017 A complex molecular switch directs stress-induced cyclin C nuclear release through SCFGrr1-mediated degradation of Med13. Molecular biology of the cell 34 29212878
2018 Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse. Biology of reproduction 30 29325037
2011 An 800  kb deletion at 17q23.2 including the MED13 (THRAP1) gene, revealed by aCGH in a patient with a SMC 17p. American journal of medical genetics. Part A 21 22162340
2018 Snf1 cooperates with the CWI MAPK pathway to mediate the degradation of Med13 following oxidative stress. Microbial cell (Graz, Austria) 18 30175106
2022 MED13 mutation: A novel cause of developmental and epileptic encephalopathy with infantile spasms. Seizure 17 36087421
2022 MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration. Cell reports 17 36543134
2020 Dexmedetomidine protects H9C2 against hypoxia/reoxygenation injury through miR-208b-3p/Med13/Wnt signaling pathway axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 17 32070878
2016 Frameshift Mutations of HSPA4 and MED13 in Gastric and Colorectal Cancers. Pathology oncology research : POR 15 27129500
2018 Exercise training prevents obesity-associated disorders: Role of miRNA-208a and MED13. Molecular and cellular endocrinology 14 29746886
2020 Could the MED13 mutations manifest as a Kabuki-like syndrome? American journal of medical genetics. Part A 10 33258286
2019 Regulation of cardiac transcription by thyroid hormone and Med13. Journal of molecular and cellular cardiology 10 30769017
2024 Expanding phenotype of MED13-associated syndrome presenting novel de novo missense variant in a patient with multiple congenital anomalies. BMC medical genomics 6 38745205
2021 Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation. Nucleic acids research 6 33444446
2024 Ksp1 is an autophagic receptor protein for the Snx4-assisted autophagy of Ssn2/Med13. Autophagy 5 37733395
2024 MED13 Gene Mutation Related to Autism Spectrum Disorder: A Case Report. Cureus 5 38854223
2024 Med13 is required for efficient P-body recruitment and autophagic degradation of Edc3 following nitrogen starvation. Molecular biology of the cell 5 39320938
2015 Deletion of the MED13 and CDK8 subunits of the Mediator improves the phenotype of a long-lived respiratory deficient mutant of Podospora anserina. Fungal genetics and biology : FG & B 4 26231682
2024 A de novo frameshift variant in MED13 gene in a patient with autism spectrum disorder and magnetic resonance imaging abnormalities mimicking tuberous sclerosis. American journal of medical genetics. Part A 2 38528425
2025 A novel frameshift variant in the MED13 gene causing intellectual developmental disorder-61 in a Chinese family. Frontiers in pediatrics 1 41195223
2024 An intrinsically disordered region in MED13 turns Mediator on/off on cue. Molecular cell 1 39178836
2024 Subunits Med12 and Med13 of Mediator Cooperate with Subunits SAYP and Bap170 of SWI/SNF in Active Transcription in Drosophila. International journal of molecular sciences 1 39684492
2026 miR-4326 predicts adverse outcomes of triple-negative breast cancer and regulates cell growth and motility through modulating MED13. World journal of surgical oncology 0 41593703
2026 Med13 is involved in the radial migration and contralateral projection of cortical neurons via PlxnA4. Communications biology 0 41663567
2026 Med12 and Med13 prevent tumorigenic dedifferentiation of intermediate neural progenitors and premature loss of neural stem cells. bioRxiv : the preprint server for biology 0 41959135
2025 Quitting Your Day Job in Response to Stress: Cell Survival and Cell Death Require Secondary Cytoplasmic Roles of Cyclin C and Med13. Cells 0 40358161

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