Affinage

MAS1

Proto-oncogene Mas · UniProt P04201

Length
325 aa
Mass
37.5 kDa
Annotated
2026-06-10
45 papers in source corpus 15 papers cited in narrative 15 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

The MAS1 symbol denotes two mechanistically distinct proteins across the timeline that nonetheless form internally coherent bodies of evidence. In yeast and Candida, MAS1 encodes the smaller 48 kDa subunit of the two-subunit mitochondrial processing protease (MPP), a matrix metalloprotease that cleaves amino-terminal targeting presequences from imported mitochondrial precursor proteins; both the MAS1 and MAS2 (51 kDa) subunits are required for catalytic activity, and MAS1 itself is self-processed during import (PMID:3044780, PMID:2905264, PMID:3061808), with import of MPP substrates such as Su9 placed downstream of the Hsp40 chaperone Ydj1 (PMID:29082232). In mammals, MAS1 is an orphan class A GPCR whose ligand-induced activation drives both G protein-dependent (Gq, Gi) and G protein-independent (β-arrestin recruitment, ERK1/2, Akt, arachidonic acid release) signaling, characterized comprehensively at recombinant receptor; notably, Ang-(1-7) showed no specific binding or signaling at recombinant MAS1 (PMID:29928987). Cryo-EM structures of agonist- and Gi-bound MAS1 reveal a non-canonical activation mechanism in which ligand-induced hydrophobic compression transmits tension to displace TM6, with M244(6.51) and F237(6.44) acting as critical molecular switches, in place of the canonical W6.48 toggle (PMID:41912627). Following agonist stimulation MAS1 internalizes via clathrin- and caveolae-dependent, dynamin-mediated routes into Rab11 slow-recycling endosomes, where β-arrestin2 is required for endosomal ERK1/2 but not Akt activation (PMID:28874464). Functionally, the receptor mediates anti-inflammatory signaling in allergic airway disease through suppression of ERK1/2, IκB-α, and Src-dependent EGFR transactivation (PMID:22339213, PMID:31675376), pro-angiogenic and vasodilatory signaling in endothelial cells dependent on physical interaction with AT1R (PMID:28082260, PMID:32324784), cardiomyocyte survival via the PTEN/PI3K/AKT pathway (PMID:35247425), and is required for the therapeutic action of ACE2 in pulmonary arterial hypertension (PMID:40248213).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1988 High

    Established the identity and catalytic role of MAS1, answering whether the gene product is an enzyme: it is the smaller subunit of the mitochondrial processing protease that removes targeting presequences from imported precursors.

    Evidence Genetic cloning, temperature-sensitive mutant analysis, and in vitro protease assays with mitochondrial fractionation in yeast

    PMID:2905264 PMID:3044780

    Open questions at the time
    • Does not resolve which subunit carries the catalytic metal-binding site versus substrate recognition
    • No structural model of the protease
  2. 1988 High

    Defined the quaternary requirement for activity, showing MPP is an obligate two-subunit enzyme rather than a single polypeptide.

    Evidence Purification of the MPP complex, subunit resolution by SDS-PAGE, and activity loss upon subunit separation

    PMID:2905264 PMID:3061808

    Open questions at the time
    • Stoichiometry and interface of subunit association not defined
    • Mechanism of activity loss on separation unresolved
  3. 2017 Medium

    Placed MAS1/MPP within the import pathway by identifying an upstream chaperone, showing Hsp40 Ydj1 physically and functionally interacts with Mas1 for precursor delivery.

    Evidence Co-IP/MS interaction mapping, deletion mutants, and Su9 mitochondrial import assays in Candida albicans

    PMID:29082232

    Open questions at the time
    • Direct versus indirect nature of the Mas1-Ydj1 interaction not fully separated from import defects
    • Single organism, single lab
  4. 2012 Medium

    Identified the mammalian MAS1 receptor as a required mediator of Ang-(1-7) anti-inflammatory signaling, addressing whether the GPCR transduces protective effects in vivo.

    Evidence Murine OVA asthma model with selective antagonist A779 and phospho-ERK1/2 / IκB-α readouts

    PMID:22339213

    Open questions at the time
    • Pharmacological antagonism does not prove direct ligand binding to MAS1
    • Cell-type origin of the signal not localized
  5. 2017 High

    Dissected MAS1 receptor trafficking and biased signaling, answering how internalized receptor routes and which effectors depend on β-arrestin2.

    Evidence Live-cell imaging, dominant-negative and shRNA perturbation of Eps15/dynamin/caveolin-1/β-arrestin2, and endosomal co-localization

    PMID:28874464

    Open questions at the time
    • Performed with Ang-(1-7) as ligand whose direct binding was later contested
    • Recycling kinetics not linked to functional outputs
  6. 2017 Medium

    Mapped the pro-angiogenic effector cascade downstream of MAS1 in endothelial cells, establishing ERK1/2 and p38 as required for tube formation and vasodilation.

    Evidence In vitro endothelial tube formation, pharmacological ERK1/2/p38 inhibition, and multi-omics pathway mapping

    PMID:28082260

    Open questions at the time
    • Pathway members inferred from omics not all functionally validated
    • Direct receptor-effector coupling not shown
  7. 2018 High

    Provided the most rigorous test of MAS1 ligand pharmacology, showing small molecules activate Gq/Gi/β-arrestin/ERK/Akt at recombinant MAS1 while Ang-(1-7) neither binds nor signals there.

    Evidence Recombinant MAS1 in HEK cells with GTPγS, β-arrestin recruitment, phospho-ERK/Akt, arachidonic acid release, DMR, and radioligand binding assays

    PMID:29928987

    Open questions at the time
    • Does not explain how Ang-(1-7) effects occur in tissue contexts
    • Endogenous physiological ligand of MAS1 unresolved
  8. 2020 Medium

    Demonstrated that MAS1 pro-angiogenic signaling requires physical partnership with AT1R, addressing a receptor-receptor dependency.

    Evidence AT1RA knockout rat hindlimb angiogenesis, endothelial tube formation, and tandem MS of the Mas1-associated complex

    PMID:32324784

    Open questions at the time
    • Direct heterodimer versus shared-pathway interaction not structurally resolved
    • Composition of the Mas1 complex only partially defined
  9. 2022 Medium

    Connected MAS1 to cardiomyocyte survival by epistasis, placing it upstream of the PTEN/PI3K/AKT axis.

    Evidence MAS1 overexpression in H9C2 cells and rat MI model with PTEN rescue and LY294002 inhibition

    PMID:35247425

    Open questions at the time
    • Mechanism of PTEN suppression by MAS1 not defined
    • Overexpression may not reflect endogenous receptor levels
  10. 2022 Medium

    Extended MAS1 signaling to metabolic control, showing it drives cAMP/CREB/CFTR-dependent insulin secretion in β-cells.

    Evidence RINm5F cell pharmacology, CFTR and MAS-1 RNAi, cAMP measurement, CREB Western blot, and insulin ELISA

    PMID:34825893

    Open questions at the time
    • G protein coupling underlying cAMP rise not defined
    • Used Ang-(1-7) as agonist despite contested binding
  11. 2024 Medium

    Showed MAS1 restrains epithelial inflammation, with bidirectional genetic manipulation linking it to NF-κB/MAPK suppression and tight-junction preservation.

    Evidence Overexpression and siRNA knockdown in EpH4 EV mammary epithelial cells with pathway and tight-junction protein readouts

    PMID:39071779

    Open questions at the time
    • Upstream ligand and receptor coupling not addressed
    • Single cell line
  12. 2025 Medium

    Established MAS1 as necessary and sufficient for ACE2 therapeutic effect in pulmonary hypertension while again decoupling Ang-(1-7) from receptor activation.

    Evidence Mas1 knockout mouse PAH model, small-molecule agonist AR234960 rescue, stabilized Ang-(1-7) failure, and RNA-seq

    PMID:40248213

    Open questions at the time
    • Endogenous activating ligand bridging ACE2 to MAS1 unidentified
    • Cytoskeletal gene rescue is correlative downstream readout
  13. 2026 High

    Resolved the structural basis of MAS1 activation, defining a non-canonical hydrophobic-compression mechanism and the TM6 switch residues for Gi coupling.

    Evidence Cryo-EM of NPFF- and AR234958-bound MAS1–Gi complexes with functional mutagenesis of M244(6.51) and F237(6.44)

    PMID:41912627

    Open questions at the time
    • Physiological relevance of NPFF as endogenous ligand not established in tissue
    • Structures do not address β-arrestin-biased conformations

Open questions

Synthesis pass · forward-looking unresolved questions
  • The endogenous physiological ligand(s) of mammalian MAS1 and the molecular reconciliation between Ang-(1-7)-dependent tissue phenotypes and its lack of direct binding at recombinant MAS1 remain unresolved.
  • Whether Ang-(1-7) acts via an AT1R/MAS1 complex or an indirect route is undefined
  • No structure of MAS1 with a confirmed physiological agonist
  • Relationship between MRGPR/CXCL17/NPFF candidate ligands and native signaling unclear

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016787 hydrolase activity 2 GO:0060089 molecular transducer activity 2 GO:0140096 catalytic activity, acting on a protein 2
Localization
GO:0005739 mitochondrion 2 GO:0005886 plasma membrane 2 GO:0005768 endosome 1
Pathway
R-HSA-162582 Signal Transduction 2 R-HSA-392499 Metabolism of proteins 2 R-HSA-9609507 Protein localization 2
Partners
ARRB2AT1RMAS2YDJ1
Complex memberships
Mitochondrial processing protease (MPP, MAS1/MAS2)

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1988 MAS1 (yeast) encodes the smaller 48 kDa subunit of the mitochondrial processing protease (MPP), a metalloprotease localized in the mitochondrial matrix that cleaves amino-terminal targeting sequences from imported mitochondrial precursor proteins. The MAS1 protein participates in its own cleavage during import into mitochondria. Genetic cloning and sequencing of MAS1, temperature-sensitive mutant analysis, in vitro protease activity assay, mitochondrial fractionation The EMBO journal High 2905264 3044780
1988 The mitochondrial processing protease consists of two non-identical, loosely associated subunits encoded by MAS1 (48 kDa) and MAS2 (51 kDa); attempts to separate the subunits caused loss of enzymatic activity, indicating both subunits are required for catalytic function. Protein purification of the MPP complex, subunit identification by SDS-PAGE, activity assay after fractionation The EMBO journal High 2905264 3061808
2017 In Candida albicans, Mas1 (ortholog of yeast MAS1) interacts physically with the Hsp40 chaperone Ydj1; loss of MAS1 or YDJ1 perturbs mitochondrial morphology and function, and deletion of YDJ1 impairs import of Su9, a protein cleaved to its mature form by Mas1/Mas2, placing Mas1 downstream of Ydj1 in the mitochondrial protein import pathway. Co-immunoprecipitation/mass spectrometry protein interaction mapping, deletion mutant analysis, mitochondrial import assay with Su9 substrate, microscopy of mitochondrial morphology Microbial cell (Graz, Austria) Medium 29082232
2012 Angiotensin-(1-7) acting through the MAS1 receptor (mammalian) attenuates allergic airway inflammation by suppressing phosphorylation of ERK1/2 and IκB-α; these effects were reversed by the selective MAS1 antagonist A779, establishing MAS1 as a required mediator of Ang-(1-7) anti-inflammatory signaling. Murine ovalbumin asthma model, pharmacological MAS1 antagonism with A779, Western blot for pERK1/2 and pIκB-α, bronchoalveolar lavage cell counts, histology British journal of pharmacology Medium 22339213
2017 MAS1 receptor (mammalian) internalization after agonist stimulation occurs through both clathrin-coated pits and caveolae in a dynamin-dependent manner; internalized receptor traffics to Rab11-positive slow recycling endosomes rather than lysosomes. ERK1/2 activation by Ang-(1-7) requires β-arrestin2 and proceeds from early endosomes, whereas Akt activation from endosomes is β-arrestin2-independent. Live-cell imaging of MAS1R-YFP, ligand-binding internalization assay, dominant-negative constructs for Eps15, dynamin, shRNA knockdown of caveolin-1 and β-arrestin2, co-localization with Rab4, Rab11, LysoTracker, Western blot for pERK1/2 and pAkt Hypertension High 28874464
2017 Low-dose Ang-(1-7) acting through the MAS1 receptor promotes angiogenesis and vasodilation in rat microvascular endothelial cells; downstream signaling components identified include Rho GTPases, PI3K, protein kinase D1, MAPK, and ERK1/2. Pharmacological inhibition of ERK1/2 and p38 MAPK blocked both endothelial tube formation and vasodilation. In vitro endothelial tube formation assay, pharmacological inhibition of ERK1/2/p38, proteomics and genomics downstream pathway mapping, MAS1 receptor antagonism Arteriosclerosis, thrombosis, and vascular biology Medium 28082260
2018 Small molecule MAS1 agonists activate multiple G protein-dependent (Gq, Gi, GTPγS binding) and independent (β-arrestin recruitment, ERK1/2 phosphorylation, Akt phosphorylation, arachidonic acid release, receptor internalization) signaling pathways through recombinant MAS1. In contrast, Ang-(1-7) failed to induce or block signaling in any of these platforms at recombinant MAS1, and radiolabeled Ang-(1-7) showed no specific binding to recombinant MAS1 (negative result). Ang-(1-7) potently inhibited both phases of AT1R-mediated Ang II signaling in rat aortic endothelial cells. Recombinant MAS1 overexpression in HEK cells, GTPγS binding assay, β-arrestin recruitment assay, Erk1/2 and Akt phosphorylation assay, arachidonic acid release assay, dynamic mass redistribution (DMR) pathway-agnostic assay, radioligand binding assay Cellular signalling High 29928987
2019 The Ang-(1-7)/MAS1 receptor axis mediates anti-inflammatory effects in allergic asthma at least in part by inhibiting Src kinase-dependent transactivation of EGFR and downstream ERK1/2 phosphorylation; Ang-(1-7) also directly inhibited neutrophil and eosinophil chemotaxis ex vivo, and all effects were reversed by A779 MAS1 antagonism. Murine OVA asthma model, Western blot for phospho-Src, phospho-EGFR, phospho-ERK1/2, A779 MAS1 antagonist, ex vivo chemotaxis assay PloS one Medium 31675376
2020 AT1R (AT1RA) physically interacts with MAS1 receptor and is required for the pro-angiogenic signaling of Ang-(1-7) through MAS1; AT1RA knockout in Dahl salt-sensitive rats impaired Ang-(1-7)-mediated skeletal muscle angiogenesis, endothelial tube formation, and altered the protein complex formed upon Ang-(1-7) binding to Mas1 as shown by tandem mass spectrometry proteomics. AT1RA knockout rat model, hindlimb angiogenesis assay, in vitro endothelial tube formation, tandem mass spectrometry proteomics of Mas1-associated protein complex PloS one Medium 32324784
2022 MAS1 overexpression in cardiomyocytes (H9C2 cells and MI rat model) decreased PTEN expression and enhanced phosphorylation of PI3K and AKT; the cardioprotective effect of MAS1 was reversed by PTEN overexpression or PI3K inhibitor LY294002, placing MAS1 upstream of the PTEN/PI3K/AKT pathway in cardiomyocyte survival signaling. MAS1 overexpression in H9C2 cells and rat MI model, Western blot for PTEN, p-PI3K, p-AKT, pharmacological inhibition with LY294002, PTEN overexpression rescue experiment, cardiomyocyte apoptosis assay International journal of biological macromolecules Medium 35247425
2022 In pancreatic β-cells (RINm5F), Ang-(1-7) activation of MAS-1 induces intracellular cAMP increase and CREB activation, upregulates CFTR expression, and potentiates glucose-stimulated insulin secretion; MAS-1 inhibition or CFTR RNAi knockdown abolished these effects, placing MAS1 upstream of cAMP/CREB/CFTR in β-cell insulin secretion. RINm5F cell pharmacology with selective MAS-1 inhibitor, RNAi knockdown of CFTR and MAS-1, cAMP measurement, Western blot for CREB activation, insulin ELISA Endocrine connections Medium 34825893
2025 In a pulmonary arterial hypertension (PAH) mouse model, ACE2 therapeutic effect is blocked in Mas1 knockout mice, establishing Mas1 as necessary for ACE2 action. The small-molecule Mas1 agonist AR234960 reproduces the ACE2 effect (sufficient). However, stabilized Ang-(1-7) failed to reproduce ACE2 effectiveness, indicating Ang-(1-7) alone does not activate Mas1 in this context. RNA-seq identified rescue of cytoskeletal and microtubule gene defects as key downstream mechanisms. Mas1 knockout mouse, PAH animal model, pharmacological Mas1 agonist AR234960, stabilized Ang-(1-7) treatment, RNA-seq downstream pathway analysis Pulmonary circulation Medium 40248213
2026 Cryo-EM structures of MAS1 (class A GPCR) bound to neuropeptide FF (NPFF) and small-molecule agonist AR234958 in complex with inhibitory G proteins reveal a conserved orthosteric binding pocket. MAS1 uses a non-canonical activation mechanism driven by ligand-induced hydrophobic compression involving residues Y248(6.55), L87(2.60), I84(2.57), and L266(7.39), transmitting mechanical tension to displace TM6 for G protein coupling rather than the canonical W6.48 toggle switch. Functional mutagenesis identified M244(6.51) and F237(6.44) on TM6 as critical molecular switches. Cryo-EM structure determination, functional mutagenesis of active-site residues, G protein coupling assay, comparative structural analysis with MRGPRX1-X4 The EMBO journal High 41912627
2025 Human CXCL17 activates MAS1 (among 10 human MRGPRs tested) at micromolar concentrations as measured by β-arrestin recruitment and chemotaxis of MAS1-transfected HEK293T cells; removal of the C-terminal fragment of CXCL17 did not affect MAS1 activation, indicating a mechanism distinct from GPR25 activation. NanoBiT-based β-arrestin recruitment assay in transfected HEK293T cells, chemotaxis assay, C-terminal deletion mutant of CXCL17 bioRxivpreprint Low
2024 Overexpression of Mas1 in mammary epithelial cells (EpH4 EV) reversed LPS-induced activation of NF-κB/MAPK signaling pathways and suppressed pro-inflammatory mediators; conversely, siRNA silencing of Mas1 enhanced LPS-induced inflammatory responses. Mas1 overexpression also reversed LPS-induced downregulation of tight junction proteins ZO-1, Occludin, and Claudin-3. Gene overexpression and siRNA knockdown in EpH4 EV cells, Western blot for NF-κB/MAPK pathway components and tight junction proteins, ELISA for inflammatory mediators Frontiers in veterinary science Medium 39071779

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2000 The imprinted antisense RNA at the Igf2r locus overlaps but does not imprint Mas1. Nature genetics 219 10802648
1988 Import of proteins into yeast mitochondria: the purified matrix processing protease contains two subunits which are encoded by the nuclear MAS1 and MAS2 genes. The EMBO journal 191 2905264
1988 MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease. The EMBO journal 161 3044780
1988 Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit. The EMBO journal 129 3061808
2012 Angiotensin-(1-7) inhibits allergic inflammation, via the MAS1 receptor, through suppression of ERK1/2- and NF-κB-dependent pathways. British journal of pharmacology 127 22339213
2017 Significance of angiotensin 1-7 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: IUPHAR Review 22. British journal of pharmacology 84 28194766
2021 ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease. Clinical science (London, England : 1979) 58 33511992
1987 Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements. Oncogene research 51 3329713
1995 Molecular and genetic analysis of the Drosophila mas-1 (mannosidase-1) gene which encodes a glycoprotein processing alpha 1,2-mannosidase. Developmental biology 50 7729592
2017 The role of ACE2, angiotensin-(1-7) and Mas1 receptor axis in glucocorticoid-induced intrauterine growth restriction. Reproductive biology and endocrinology : RB&E 45 29321064
2018 Angiotensin (1-7) does not interact directly with MAS1, but can potently antagonize signaling from the AT1 receptor. Cellular signalling 44 29928987
2000 Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene. Experimental neurology 43 10785460
2020 Involvement of ACE2/Ang-(1-7)/MAS1 Axis in the Regulation of Ovarian Function in Mammals. International journal of molecular sciences 33 32604999
2017 Mechanisms of Mas1 Receptor-Mediated Signaling in the Vascular Endothelium. Arteriosclerosis, thrombosis, and vascular biology 33 28082260
2017 Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2. Microbial cell (Graz, Austria) 30 29082232
2021 Prenatal dexamethasone exposure induces nonalcoholic fatty liver disease in male rat offspring via the miR-122/YY1/ACE2-MAS1 pathway. Biochemical pharmacology 29 33460628
2014 Sensitivity of Neurospora crassa to a marine-derived Aspergillus tubingensis anhydride exhibiting antifungal activity that is mediated by the MAS1 protein. Marine drugs 26 25257783
2015 Expression of MAS1 in breast cancer. Cancer science 24 26080617
2019 Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma. PloS one 22 31675376
2017 MAS1 Receptor Trafficking Involves ERK1/2 Activation Through a β-Arrestin2-Dependent Pathway. Hypertension (Dallas, Tex. : 1979) 19 28874464
2017 Angiotensin-(1-7)-mediated Mas1 receptor/NF-κB-p65 signaling is involved in a cigarette smoke-induced chronic obstructive pulmonary disease mouse model. Environmental toxicology 18 28960804
1994 Analysis of the involvement of ocs-like bZip-binding elements in the differential strength of the bidirectional mas1'2' promoter. Plant physiology 17 8029353
2018 Improving the Catalytic Activity and Thermostability of MAS1 Lipase by Alanine Substitution. Molecular biotechnology 15 29450814
2021 Asthma: role of the angiotensin-(1-7)/Mas (MAS1) pathway in pathophysiology and therapy. British journal of pharmacology 14 34235725
2021 Angiotensin (1-7) Attenuates the Nociceptive Behavior Induced by Substance P and NMDA via Spinal MAS1. Biological & pharmaceutical bulletin 10 33952831
2020 Sustainable Iron Recovery and Biodiesel Yield by Acid-Adapted Microalgae, Desmodesmus sp. MAS1 and Heterochlorella sp. MAS3, Grown in Synthetic Acid Mine Drainage. ACS omega 10 32258924
2020 Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats. PloS one 9 32324784
2013 Comparison of effect of sex hormone manipulation during neonatal period, on mRNA expression of Slc9a4, Nr3c2, Htr5b and Mas1 in hippocampus and frontal cortex of male and female rats. Journal of biological regulators and homeostatic agents 9 24152851
2019 An Efficient Synthesis of Lysophosphatidylcholine Enriched with n-3 Polyunsaturated Fatty Acids by Immobilized MAS1 Lipase. Journal of agricultural and food chemistry 8 31668065
2013 Distinct expression of Mas1-related G-protein-coupled receptor B4 in dorsal root and trigeminal ganglia--implications for altered behaviors in acid-sensing ion channel 3-deficient mice. Journal of molecular neuroscience : MN 8 23900719
2022 G protein-coupled receptor MAS1 induces an inhibitory effect on myocardial infarction-induced myocardial injury. International journal of biological macromolecules 7 35247425
2021 A Non-Peptidic MAS1 Agonist AVE0991 Alleviates Hippocampal Synaptic Degeneration in Rats with Chronic Cerebral Hypoperfusion. Current neurovascular research 6 34636310
2019 Insight into the Modification of Phosphatidylcholine with n-3 Polyunsaturated Fatty Acids-Rich Ethyl Esters by Immobilized MAS1 Lipase. Molecules (Basel, Switzerland) 5 31569526
2018 The Expression of MAS1, an Angiotensin (1-7) Receptor, in the Eutopic Proliferative Endometria of Endometriosis Patients. Gynecologic and obstetric investigation 4 29982252
2022 Angiotensin(1-7) activates MAS-1 and upregulates CFTR to promote insulin secretion in pancreatic β-cells: the association with type 2 diabetes. Endocrine connections 3 34825893
2021 Aerobic training-mediated DNA hypermethylation of Agtr1a and Mas1 genes ameliorate mesenteric arterial function in spontaneously hypertensive rats. Molecular biology reports 3 34743271
2018 Canine MAS1: monoallelic expression is suggestive of an imprinted gene. Animal genetics 2 30062832
2025 Identification and structural analysis of a surface layer protein from Geobacillus thermopakistaniensis MAS1: highlighting its larvicidal potential against Culex quinquefasciatus, Anopheles stephensi and Aedes aegypti. International journal of biological macromolecules 1 40403796
2024 Overexpression of the Mas1 gene mitigated LPS-induced inflammatory injury in mammary epithelial cells by inhibiting the NF-κB/MAPKs signaling pathways. Frontiers in veterinary science 1 39071779
2022 Whole exome sequencing identifies a rare variant in MAS1 gene in a subject with lethal COVID-19. Gene reports 1 36348959
2020 Expression of Concern to: The role of ACE2, angiotensin-(1-7) and Mas1 receptor axis in glucocorticoid-induced intrauterine growth restriction. Reproductive biology and endocrinology : RB&E 1 32450887
2026 Structural insight into ligand binding and activation of the orphan GPCR Mas1. The EMBO journal 0 41912627
2026 Transcriptomic Evidence of MAS1 Receptor Dysregulation and a Failed Compensatory State in Human Vascular Cognitive Impairment. medRxiv : the preprint server for health sciences 0 42180374
2025 Mas1 Receptor Activation is Necessary and Sufficient to Transduce ACE2 Effect in PAH, But Ang(1-7) Alone is Insufficient. Pulmonary circulation 0 40248213
2023 [Expression of Mas1 receptor in human placenta and its effect on the function of trophoblast cells in pre-eclampsia patients]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 0 37743304

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