Beta-arrestin-2 · UniProt P32121
ARRB2 (β-arrestin 2) is a multifunctional cytoplasmic scaffolding protein that assembles multi-protein complexes downstream of activated G protein-coupled receptors to both dampen and redirect signaling (PMID:32035036). Structurally, it couples to dimeric family C GPCRs through combined 'tail' and 'core' interactions, supporting receptor desensitization. As a negative regulator of inflammatory signaling, ARRB2 is recruited together with TRAF6 and PP2A to the DRD5 receptor via specific motifs, where it impairs TRAF6-mediated NF-κB activation and pro-inflammatory gene expression (PMID:32035036), and it binds the NLRP3 inflammasome to suppress its activation until competed away by SUMOylated TRPC1 (PMID:39921112). ARRB2 also sequesters JNK in the cytoplasm of sensory neurons to restrain mu-opioid receptor-driven JNK signaling in a ligand-specific manner (PMID:22491351), and participates in an AKT/ARRB2/PDE4 lipid-raft complex that degrades cAMP (PMID:26549736). Beyond suppression, ARRB2 directly binds and activates ERK1/2 and AKT to scaffold proliferative and pro-survival MAPK signaling across endothelial progenitor cells, prostate cancer, and GPR54/KISS1R-dependent neuroprotection (PMID:32863967, PMID:38341429, PMID:33989759). Physiologically, ARRB2 counterbalances GPCR signaling to control fluid homeostasis and blood pressure in salt-sensitive hypertension in an isoform-specific manner (PMID:36215165), and its loss hyperactivates Akt-mTOR signaling with impaired autophagy and mitochondrial function (PMID:36796753). ARRB2 expression is itself tightly controlled, being transcriptionally driven by STAT5B and Egr1 (the latter repressed via WDR4-DDX20) (PMID:38341429, PMID:37783676).
Establishing the physical genomic location of human ARRB2 anchored it as a discrete gene available for functional study.
Evidence FISH mapping to chromosome band 17p13
Resolved how ARRB2 shapes opioid receptor outputs by showing it spatially confines JNK signaling, explaining ligand-biased behavioral phenotypes.
Evidence β-arr2 knockout mice with JNK inhibitor epistasis and immunofluorescence in DRG neurons, plus morphine/fentanyl ligand controls
Identified ARRB2 as a structural component of a lipid-raft cAMP-degrading machine, linking it to control of NF-κB-driven cytokine production.
Evidence Co-IP of AKT/ARRB2/PDE4 complex, lipid raft fractionation, and miR-150 luciferase targeting assay
Defined a receptor-templated mechanism for ARRB2's anti-inflammatory role, showing DRD5 recruits ARRB2 and PP2A to inactivate TRAF6-NF-κB signaling.
Evidence Reciprocal Co-IP with EFD/IYX(X)I/L motif mutagenesis plus macrophage and in vivo sepsis/meningitis models
Showed ARRB2 acts as a positive scaffold for ERK1/2 and AKT, broadening its role from signaling brake to pro-proliferative/pro-survival driver across cell types.
Evidence Co-IP of ARRB2-ERK1/2 and ARRB2-AKT plus gain/loss-of-function in EPCs and KISS1R-dependent neuroprotection models in vivo
Demonstrated an isoform-specific physiological function for ARRB2 in counterbalancing GPCR signaling for fluid and blood pressure homeostasis.
Evidence Global Arrb2 and Arrb1 knockout mice with 2-bottle choice, telemetric BP, and DOCA-salt hypertension model
Connected ARRB2 levels to disease-relevant signaling rewiring, showing both that elevated ARRB2 drives pulmonary hypertension phenotypes and that ARRB2 loss deranges Akt-mTOR/autophagy in neurons.
Evidence BMPR2 KO + ARRB2 reduction genetic epistasis in mouse/human PASMC; Arrb2-/- mice with autophagy and mitochondrial readouts in hippocampus
Defined transcriptional control of ARRB2, identifying an Egr1-driven program repressed by a WDR4-DDX20 adaptor module.
Evidence Co-IP of WDR4-DDX20-Egr1, fractionation, Egr1-ARRB2 luciferase reporter in bladder cancer cells
Linked an upstream transcription factor to ARRB2's pro-tumorigenic MAPK scaffolding, showing STAT5B drives ARRB2 to potentiate ERK1/2.
Evidence ChIP-qPCR and luciferase for STAT5B-ARRB2 promoter binding plus ARRB2-ERK1/2 Co-IP and prostate cancer in vivo assays
Refined the structural basis for ARRB2 coupling to family C GPCRs and its competitive displacement at the inflammasome.
Evidence Cryo-EM/smFRET/MD of mGluR-β-arrestin megacomplexes (preprint); Co-IP and domain mapping of TRPC1-ARRB2 versus NLRP3-ARRB2 in stroke models
Expanded ARRB2's reach into post-transcriptional and metabolic regulation, with m6A-dependent control of ARRB2 and ARRB2-mediated effects on lipid and bile acid metabolism and immune cell function.
Evidence m6A assays, RIP, METTL3/IGF2BP1 manipulation, AMPK pathway readouts, metabolomics, and Treg adoptive transfer across multiple disease models
PMID:33871024 PMID:40119070 PMID:41107955 PMID:41986296
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 2020 | Dopamine receptor DRD5, via EFD and IYX(X)I/L motifs in its C-terminal and IC3 loop, directly recruits both TRAF6 and ARRB2 to form a multi-protein complex also containing TAK1, IKKs, and PP2A. Within this complex, ARRB2 acts as a negative regulator of TRAF6, and the DA-DRD5-ARRB2-PP2A signaling axis impairs TRAF6-mediated activation of NF-κB and expression of pro-inflammatory genes. | Co-immunoprecipitation, domain-mapping mutagenesis (EFD and IYX(X)I/L motif mutations), in vivo mouse models (S. aureus sepsis and meningitis), macrophage knockdown/overexpression experiments | Molecular cell | High | 32035036 |
| 2015 | ARRB2 directly participates in an AKT/ARRB2/PDE4 trimeric complex that is recruited into the lipid raft to degrade cAMP. miR-150 represses ARRB2 (and PDE4) expression and prevents this complex from entering the lipid raft, thereby interrupting cAMP degradation and inhibiting IL-2 and TNF production via the NF-κB pathway. | miRNA overexpression with western blot, RT-PCR; lipid raft fractionation; co-immunoprecipitation of AKT/ARRB2/PDE4 complex; luciferase reporter assay for miR-150 targeting of ARRB2 | Immunology letters | Medium | 26549736 |
| 2023 | Loss of BMPR2 in pulmonary artery smooth muscle cells (PASMC) causes upregulation of ARRB2 via a pERK1/2-pP38-pSMAD2/3 cascade. Elevated ARRB2 in turn activates pAKT-mediated inactivation of GSK3-beta, drives CTNNB1 (β-catenin) nuclear translocation, and reduces RHOA and RAC1, producing a hypocontractile, hyperproliferative phenotype. Genetic reduction of ARRB2 in BMPR2-deficient PASMC restores normal signaling and contractility and prevents persistent pulmonary hypertension in mice with inducible SMC-specific BMPR2 loss. | SMC-specific Bmpr2 knockout mice, siRNA knockdown in human PASMC, PASMC from PAH patients with BMPR2 mutation, western blot for pERK1/2, pP38, pSMAD2/3, ARRB2, pAKT, GSK3β, β-catenin, RHOA, RAC1; echocardiography, RVSP measurement, proliferation/contractility assays | Circulation research | High | 36744494 |
| 2012 | β-arrestin 2 (ARRB2/β-arr2) sequesters JNK in the cytoplasm of dorsal root ganglion neurons; deletion of β-arr2 results in altered intracellular distribution of JNK and phospho-cJun, and unmasks morphine-specific (but not fentanyl-specific) activation of the JNK cascade. JNK inhibitors reverse the enhanced analgesia, reduced locomotion, and enhanced sensitization phenotypes of β-arr2-/- mice to wild-type levels, placing ARRB2 as a negative regulator of JNK signaling downstream of mu-opioid receptor activation. | β-arr2 knockout mice, pharmacological JNK inhibitors (two compounds), immunofluorescence for phospho-cJun nuclear localization in DRG neurons, behavioral assays (analgesia, locomotion, sensitization), PKC inhibitor comparison | Neuropsychopharmacology | High | 22491351 |
| 1994 | The human ARRB2 gene was chromosomally mapped to band 17p13 by fluorescence in situ hybridization (FISH), establishing its physical genomic location. | Fluorescence in situ hybridization (FISH) on human chromosomes | Genomics | Medium | 7695743 |
| 2021 | In endothelial progenitor cells (EPCs), ARRB2 physically interacts with and activates ERK1/2 and AKT signaling pathways, promoting EPC proliferation, migration, adhesion, tube formation, and protection from hypoxia-induced apoptosis. ARRB2-overexpressing EPCs transplanted into ischemic hind-limb mice showed significantly improved blood flow restoration and capillary density. | Lentivirus-mediated overexpression and knockdown of Arrb2 in EPCs, Co-IP for ARRB2-ERK1/2 and ARRB2-AKT interaction, proliferation/migration/tube formation assays, Arrb2-deficient mice with hind-limb ischemia model, laser Doppler measurements, histology | Theranostics | Medium | 32863967 |
| 2021 | ARRB2 induces hepatic lipid metabolism disorders and lipid accumulation through the AMPK pathway in alcoholic fatty liver, increasing both fatty acid and cholesterol synthesis; knockdown of Arrb2 in mouse liver in vivo and in AML-12 cells in vitro reversed lipid accumulation, and LC-MS metabolomics identified primary bile acids as the most significantly altered hepatic lipid metabolites. | In vivo Arrb2 knockdown in AFL mice, siRNA and pEX3-Arrb2 overexpression in AML-12 cells, western blot for AMPK pathway proteins, LC-MS metabolomics | Clinical science | Medium | 33871024 |
| 2021 | ARRB2 promotes colorectal cancer cell growth, motility, and apoptosis resistance by regulating the expression of Wilms tumor 1 associated protein (WTAP); knockdown of ARRB2 decreased WTAP expression and attenuated cancer pathway activation. | ARRB2 knockdown in CRC cell lines, western blot, AOM/DSS mouse model, cell proliferation/migration/apoptosis assays | Acta biochimica et biophysica Sinica | Low | 33367479 |
| 2021 | GPR54 (KISS1R) requires ARRB2 as a functional adaptor to mediate neuroprotective effects of kisspeptin-54 (KP54); ARRB2 siRNA knockout offsets the neuroprotective effects of KP54, and the pathway operates through ARRB2/AKT/GSK3β to reduce oxidative stress and neuronal apoptosis after subarachnoid hemorrhage. | ARRB2 siRNA intracerebroventricular administration in rats, GPR54 antagonist (KP234), western blot, immunofluorescence, behavioral tests, TUNEL/Fluoro-Jade C staining in SAH rat model | Free radical biology & medicine | Medium | 33989759 |
| 2025 | SUMOylated TRPC1 in microglia facilitates interaction between TRPC1 and ARRB2; normally ARRB2 binds to NLRP3 to suppress inflammasome activation. SUMOylation of TRPC1 disrupts the NLRP3/ARRB2 complex by competing for ARRB2 binding (ARRB2 binds residues 46–61 of TRPC1 N-terminus), thereby activating NLRP3 signaling and exacerbating neuroinflammation after stroke. | Co-IP for TRPC1-ARRB2 and NLRP3-ARRB2 interaction, TRPC1 SUMOylation-deficient mice, MCAO/R model, oxygen-glucose deprivation/regeneration in vitro, domain mapping (TRPC1 residues 46–61), western blot, behavior and infarct volume measurements | Neurobiology of disease | Medium | 39921112 |
| 2023 | WDR4 acts as an adaptor that promotes nuclear localization of DDX20 and bridges DDX20 with transcription factor Egr1, thereby inhibiting Egr1-promoted transcriptional expression of ARRB2. This WDR4-mediated transcriptional suppression of ARRB2 contributes to bladder cancer progression and lymph node metastasis. | Co-IP for WDR4-DDX20-Egr1 complex, subcellular fractionation for DDX20 nuclear localization, luciferase reporter for Egr1-driven ARRB2 transcription, WDR4 knockdown/overexpression in bladder cancer cells, in vivo metastasis models, IHC | Oncogenesis | Medium | 37783676 |
| 2024 | STAT5B acts as a transcription factor that directly drives ARRB2 transcription downstream of PRL/PRLR signaling; ARRB2 in turn physically binds ERK1/2, enhancing phosphorylation of ERK1/2 and activating the MAPK pathway to promote prostate cancer progression. | ChIP-qPCR and luciferase reporter gene assay for STAT5B binding to ARRB2 promoter; Co-IP for ARRB2-ERK1/2 interaction; STAT5B and ARRB2 knockdown in VCaP and 22Rv1 cells; in vitro and in vivo tumor assays; IHC for pSTAT5B, ARRB2, pERK1/2 | Cell death & disease | Medium | 38341429 |
| 2022 | ARRB2 deficiency (global knockout) in mice causes elevated saline intake at baseline and exacerbated fluid intake and pressor response under DOCA-salt hypertension, indicating that ARRB2 counterbalances canonical GPCR signaling to regulate fluid homeostasis and blood pressure in salt-sensitive hypertension. ARRB1 knockout did not produce the same saline intake phenotype, indicating ARRB2 specificity. | Global Arrb2 knockout and Arrb1 knockout mice, 2-bottle choice paradigm, telemetric blood pressure measurement, DOCA-salt hypertension model, plasma sodium measurement | Hypertension | Medium | 36215165 |
| 2023 | Deletion of Arrb2 in mice causes hyperactivation of Akt-mTOR signaling in the hippocampus, resulting in decreased autophagy (reduced LC3B), and mitochondrial dysfunction characterized by reduced membrane potential and ATP production and increased ROS in hippocampal neurons. | Arrb2-/- mice, western blot for LC3B, Akt, mTOR and downstream targets, mitochondrial membrane potential assay, ATP measurement, ROS detection in hippocampal neurons | Neuroscience | Medium | 36796753 |
| 2025 | REG3A functions as an exocytosis protein that binds to GPR54, increasing membrane localization of GPR54, which then engages ARRB2 as a scaffolding molecule to activate ERK1/2 signaling and suppress gemcitabine-induced apoptosis in pancreatic cancer cells. | RNA-seq, PPI analysis, Co-IP for REG3A-GPR54 and GPR54-ARRB2 interactions, ARRB2 siRNA, GPR54 antagonist KP234, Reg3g knockout mice, in vitro and in vivo gemcitabine resistance assays | Biochemical pharmacology | Medium | 40935160 |
| 2022 | ARRB2 is the direct target of miR-361, and the lncRNA GATA3-AS1 acts as a ceRNA to sequester miR-361, thereby indirectly upregulating ARRB2. ARRB2 activates the Src/Akt pathway in endometrial carcinoma cells, promoting invasion and migration. | Dual-luciferase reporter assay and RNA immunoprecipitation (RIP) for miR-361/ARRB2 interaction and GATA3-AS1/miR-361 interaction; western blot for Src/Akt; ARRB2 overexpression/knockdown; in vivo xenograft assays | Journal of molecular medicine | Low | 35788718 |
| 2025 | ARRB2 stabilizes CDC25A mRNA through IGF2BP1 in an m6A-dependent manner; CDC25A in turn promotes FOXO3 phosphorylation and cytoplasmic retention, enabling Snail1 transcription and EMT, thereby facilitating cervical cancer proliferation and metastasis. | RNA immunoprecipitation (RIP) for ARRB2-IGF2BP1-CDC25A mRNA complex, m6A methylation assay, ARRB2 and CDC25A knockdown/overexpression, western blot, in vivo tumor models | NPJ precision oncology | Low | 40119070 |
| 2025 | METTL3-dependent m6A methylation of ARRB2 mRNA upregulates ARRB2 protein expression in intrahepatic cholangiocarcinoma; elevated ARRB2 then promotes YAP nuclear translocation and activates the Raf-MEK-ERK signaling axis to drive ICC malignant progression and resistance to pemigatinib. | m6A methylation assay, METTL3 overexpression/knockdown, ARRB2 knockdown, YAP nuclear fractionation, western blot for Raf-MEK-ERK, pemigatinib resistance assays in vitro and in vivo | Cell death & disease | Low | 41986296 |
| 2025 | In Treg cells, β2-AR agonist terbutaline increases ARRB2 expression and phospho-ERK1/2 levels; ARRB2 gene silencing reduces this pERK1/2 increase and impairs TGF-β and IL-10 production, while ARRB2 overexpression enhances these effects. Adoptive transfer of ARRB2-overexpressing Treg cells into CIA mice reduces joint inflammation and Th17 cytokine production, placing the β2-AR/ARRB2/ERK1/2 axis as a non-canonical signaling pathway that enhances Treg suppressive function. | ARRB2 siRNA and overexpression in iTreg cells, western blot for pERK1/2, ELISA for TGF-β and IL-10, Teff proliferation suppression assay, adoptive transfer into CIA mice, clinical arthritis scoring, cytokine measurement | Arthritis research & therapy | Medium | 41107955 |
| 2025 | Cryo-EM structures of mGluR8 with β-arr1 and molecular dynamics simulations reveal that β-arrestin (including β-arr2 as part of mGluR/β-arr1/β-arr2 megacomplexes identified by combinatorial mutagenesis) couples to dimeric family C GPCRs with 2:1 or 2:2 stoichiometry via 'tail' and 'core' interactions, and that β-arr-bound mGluR8 adopts a transducer-specific active state; steric interaction with both subunits and lipid bilayer supports a desensitization mechanism. | Cryo-EM structural determination, single-molecule pulldown stoichiometry assay, single-molecule FRET, molecular dynamics simulations, combinatorial mutagenesis | bioRxivpreprint | Medium | |
| 2026 | In hepatocytes, Arrb2 remodels bile acid metabolism by upregulating Cyp7a1, increasing levels of the bile acid metabolite 6-ketoLCA; 6-ketoLCA in turn activates TGR5 on macrophages to promote M2 polarization, thereby attenuating hepatic ischemia-reperfusion injury. The drug dutasteride was identified as an enhancer of the Arrb2 promoter that upregulates Arrb2 expression. | Hepatocyte-specific and global Arrb2 models, 70% hepatic I/R mouse model, bile acid profiling, macrophage polarization assays (M1/M2 markers), TGR5 functional experiments, dutasteride promoter activity assay | Hepatology communications | Low | 42043875 |
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2020 | Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation. | Molecular cell | 77 | 32035036 |
| 2003 | Epidemiology of rifampin ADP-ribosyltransferase (arr-2) and metallo-beta-lactamase (blaIMP-4) gene cassettes in class 1 integrons in Acinetobacter strains isolated from blood cultures in 1997 to 2000. | Antimicrobial agents and chemotherapy | 58 | 12654674 |
| 2015 | MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway. | Immunology letters | 54 | 26549736 |
| 2023 | Dysregulated Smooth Muscle Cell BMPR2-ARRB2 Axis Causes Pulmonary Hypertension. | Circulation research | 44 | 36744494 |
| 1994 | Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes. | Genomics | 41 | 7695743 |
| 2021 | Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3β signaling pathway. | Free radical biology & medicine | 36 | 33989759 |
| 2012 | Evidence that behavioral phenotypes of morphine in β-arr2-/- mice are due to the unmasking of JNK signaling. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology | 28 | 22491351 |
| 2008 | The coding-synonymous polymorphism rs1045280 (Ser280Ser) in beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia. | European journal of neurology | 22 | 19049562 |
| 2021 | miRNAs through β-ARR2/p-ERK1/2 pathway regulate the VSMC proliferation and migration. | Life sciences | 21 | 34111458 |
| 2021 | ARRB2 promotes colorectal cancer growth through triggering WTAP. | Acta biochimica et biophysica Sinica | 20 | 33367479 |
| 2014 | The genetic variation of ARRB2 is associated with late-onset Alzheimer's disease in Han Chinese. | Current Alzheimer research | 20 | 24635845 |
| 2021 | Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver. | Clinical science (London, England : 1979) | 16 | 33871024 |
| 2020 | Arrb2 promotes endothelial progenitor cell-mediated postischemic neovascularization. | Theranostics | 13 | 32863967 |
| 2024 | PRL-mediated STAT5B/ARRB2 pathway promotes the progression of prostate cancer through the activation of MAPK signaling. | Cell death & disease | 11 | 38341429 |
| 2022 | ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation. | Hypertension (Dallas, Tex. : 1979) | 11 | 36215165 |
| 2012 | Association study of the β-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population. | Psychiatric genetics | 10 | 22472784 |
| 2020 | Repeated social defeat promotes persistent inflammatory changes in splenic myeloid cells; decreased expression of β-arrestin-2 (ARRB2) and increased expression of interleukin-6 (IL-6). | BMC neuroscience | 9 | 32471349 |
| 2021 | β-Arrestin 2 (ARRB2) Polymorphism is Associated With Adverse Consequences of Chronic Heroin Use. | The American journal on addictions | 8 | 33783060 |
| 2025 | Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2. | Neurobiology of disease | 7 | 39921112 |
| 2023 | WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2. | Oncogenesis | 7 | 37783676 |
| 2022 | LncRNA GATA3-AS1 promoted invasion and migration in human endometrial carcinoma by regulating the miR-361/ARRB2 axis. | Journal of molecular medicine (Berlin, Germany) | 7 | 35788718 |
| 2025 | Treg cells mitigate inflammatory responses and symptoms via β2-AR/β-Arr2/ERK signaling in an experimental rheumatoid arthritis. | Arthritis research & therapy | 6 | 41107955 |
| 2022 | The Comprehensive Analysis of Hub Gene ARRB2 in Prostate Cancer. | Disease markers | 5 | 36284990 |
| 2023 | Deletion of Arrb2 Down-regulates Autophagy in the Mouse Hippocampus via Akt-mTOR Pathway Activation. | Neuroscience | 4 | 36796753 |
| 2025 | REG3A promotes gemcitabine resistance in pancreatic cancer via the GPR54/ARRB2/ERK1/2 ligand-directed signaling pathway. | Biochemical pharmacology | 3 | 40935160 |
| 2024 | MiR-483-3p promotes dental pulp stem cells osteogenic differentiation via the MAPK signaling pathway by targeting ARRB2. | In vitro cellular & developmental biology. Animal | 3 | 38833209 |
| 2025 | Dissemination of arr-2 and arr-3 is associated with class 1 integrons in Klebsiella pneumoniae clinical isolates from Portugal. | Medical microbiology and immunology | 2 | 39775075 |
| 2025 | ARRB2 promotes cervical cancer progression via stabilizing CDC25A mRNA through m6A-IGF2BP1-dependent manner. | NPJ precision oncology | 2 | 40119070 |
| 2025 | Systems Genetics Reveals the Gene Regulatory Mechanisms of Arrb2 in the Development of Autism Spectrum Disorders. | Genes | 2 | 40428426 |
| 2024 | Interactive effects of ARRB2 and CHRNA5 genetic polymorphisms on cognitive function in Chinese male methamphetamine use disorder patients. | The American journal on addictions | 1 | 39545854 |
| 2023 | Exploring the Binding Affinity of the ARR2 GARP DNA Binding Domain via Comparative Methods. | Genes | 1 | 37628689 |
| 2026 | N6-methyladenosine-mediated up-regulation of ARRB2 regulates intrahepatic cholangiocarcinoma malignant progression and pemigatinib resistance through MAPK and Hippo signaling pathways. | Cell death & disease | 0 | 41986296 |
| 2026 | Arrb2 in hepatocytes promotes M2 macrophage polarization, ameliorates hepatic ischemia-reperfusion injury through upregulating metabolite 6-ketoLCA. | Hepatology communications | 0 | 42043875 |
| 2025 | A Preliminary Prospective Study on the Association of Polymorphisms in BDNF, ARRB2 and KCNJ6 and Response to Fentanyl for Pain Management in Advanced Cancer. | Cancer control : journal of the Moffitt Cancer Center | 0 | 40973140 |
| 2025 | An explainable predictive machine learning model reveals ARRB2 as a key gene in post-traumatic stress disorder: A GEO database study. | Journal of psychiatric research | 0 | 41418454 |
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