Affinage

MAP2

Microtubule-associated protein 2 · UniProt P11137

Length
1827 aa
Mass
199.5 kDa
Annotated
2026-06-10
100 papers in source corpus 39 papers cited in narrative 39 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MAP2 is a dendrite-enriched microtubule-associated protein that builds and stabilizes the dendritic cytoskeleton and serves as a phosphorylation-gated signaling scaffold during neuronal differentiation (PMID:1997209, PMID:12163474). Its C-terminal domain, comprising three imperfect 18-amino-acid repeats, constitutes the microtubule-binding region that copurifies with microtubules through repeated polymerization cycles, nucleates and stabilizes microtubules, and promotes their acetylation while preserving plus-end assembly (PMID:3142041, PMID:1487506, PMID:8421058). Through this domain MAP2 also cross-links microtubules to neurofilaments and binds G-actin/microfilaments, with microtubule-bound MAP2 showing reduced affinity for actin, and it imparts the stiffness and bundling that drive process outgrowth against cortical actin tension (PMID:3045269, PMID:8038171, PMID:8392463). The MAP2-specific N-terminal projection domain sets inter-microtubule spacing and process architecture across isoforms generated by alternative splicing, and prevents axonal entry by conferring tighter microtubule binding in the cell body and dendrites (PMID:8868472, PMID:2770869, PMID:7857650); dendritic localization depends both on a protein-intrinsic targeting signal and on selective dendritic transport of high-molecular-weight MAP2 mRNA in low-copy RNPs (PMID:8627364, PMID:3200318, PMID:21869818). MAP2 function is governed bidirectionally by phosphorylation: proline-directed and serine/threonine kinases (cdc2, GSK3β, MARK, ERK/MAPK, PKA, Rho-kinase) detach it from microtubules or shift it toward actin, while phosphatases PP2A and calcineurin (PP2B), acting downstream of metabotropic and NMDA glutamate receptors, restore microtubule binding (PMID:9376363, PMID:10542369, PMID:10826493, PMID:11029056, PMID:8789950, PMID:2169265, PMID:10640627, PMID:22403409). Beyond a structural role, MAP2 acts as an A-kinase anchoring protein that recruits PKA via the RII regulatory subunit to dendrites and L-type Ca2+ channels to sustain CREB signaling, binds the SH3 domains of Src, Grb2 and Fyn in a phosphorylation-regulated manner, and functions as a receptor for the neurosteroid pregnenolone to stimulate microtubule polymerization and neurite outgrowth (PMID:12163474, PMID:10514522, PMID:2254332, PMID:10781592, PMID:11546790, PMID:16537405). Hyperphosphorylation at Ser1782 in schizophrenia reduces microtubule binding and, in a phosphomimetic mouse, shrinks dendritic complexity and spine density while suppressing protein synthesis (PMID:33526823).

Mechanistic history

Synthesis pass · year-by-year structured walk · 23 steps
  1. 1988 High

    Localizing the microtubule-binding activity to a defined region answered which part of the large MAP2 molecule physically engages tubulin, and showed MAP2 simultaneously bridges microtubules to neurofilaments.

    Evidence In vitro translation of subcloned fragments with microtubule copurification, plus immunoelectron microscopy and reconstitution with purified neurofilament L and tubulin

    PMID:3045269 PMID:3142041

    Open questions at the time
    • Repeat-level stoichiometry of microtubule binding not resolved
    • Whether the same repeats mediate neurofilament cross-bridging untested
  2. 1988 High

    Demonstrating that MAP2 mRNA is selectively dendritic while tubulin mRNA stays in the soma established subcellular mRNA targeting as a candidate mechanism for MAP2 compartmentalization.

    Evidence In situ hybridization with specific cDNA probes in developing brain

    PMID:3200318

    Open questions at the time
    • cis-element directing dendritic mRNA transport not mapped
    • Whether mRNA targeting is necessary for protein localization unresolved at this stage
  3. 1989 High

    Resolving that high-MW MAP2 and MAP2c arise by alternative splicing from one gene clarified that the dendritic mRNA targeting signal is isoform-specific to the high-MW form.

    Evidence cDNA cloning, sequence comparison, and isoform-specific in situ hybridization

    PMID:2770869

    Open questions at the time
    • Functional consequence of the 1342-residue sidearm in vivo not directly tested here
  4. 1992 High

    Loss-of-function showed MAP2 is required for neurite extension and cell-cycle exit, moving it from a structural marker to a driver of differentiation; concurrent gain-of-function showed MAPs directly stabilize microtubules and promote tubulin acetylation.

    Evidence Antisense RNA in differentiating embryonal carcinoma cells, and MAP2c/tau cDNA transfection into fibroblasts with drug-resistance and acetylated-tubulin readouts

    PMID:1487506 PMID:1997209

    Open questions at the time
    • Mechanistic link between microtubule stabilization and cell-cycle withdrawal unestablished
    • Whether acetylation is cause or consequence of stabilization unresolved
  5. 1992 High

    Heterologous expression established MAP2c as sufficient to nucleate MTOC-independent, stiff, stable, bundled microtubules and to build processes against cortical actin, defining its architectural function.

    Evidence cDNA transfection in non-neuronal cells with EM, cytochalasin B treatment, time-lapse imaging, and tubulin exchange/photoactivation assays

    PMID:1338311 PMID:8392463 PMID:8421058

    Open questions at the time
    • Molecular basis of MTOC-independent nucleation not defined
    • How bundling tension translates to neurite initiation in neurons untested
  6. 1990 High

    Demonstrating NMDA-receptor-driven rapid MAP2 dephosphorylation tied cytoskeletal regulation to glutamatergic synaptic activity via a calcineurin-like phosphatase.

    Evidence 32P labeling of hippocampal slices with NMDA-receptor antagonist dissection

    PMID:2169265

    Open questions at the time
    • Phosphatase identity inferred pharmacologically, not biochemically confirmed here
    • Phosphosites not mapped
  7. 1994 High

    Reconstitution and site mapping established that MAP2 binds both microtubules and actin in mutually constraining fashion, and that proline-directed kinases phosphorylate a defined Ser-Pro site, beginning the phospho-code for MAP2 binding.

    Evidence Solid-phase binding assays with purified microtubules/actin, phosphatidylinositol vesicle binding, and Ser136 mutagenesis with kinase-specificity assays and microinjection

    PMID:7525290 PMID:8025110 PMID:8038171

    Open questions at the time
    • Functional relevance of Ser136 phosphorylation unclear (microtubule reorganization was independent of it)
    • Physiological role of MAP2 phosphatidylinositol binding untested
  8. 1995 High

    Domain-swap analysis showed the N-terminal projection domain excludes MAP2 from the axon and the microtubule-binding domain confers compartment-specific affinity, explaining dendritic enrichment at the protein level.

    Evidence Transfection of tagged tau/MAP2/MAP2C and chimeric/deletion mutants into primary neurons

    PMID:7857650

    Open questions at the time
    • The proposed phosphorylation control of compartmental binding not directly demonstrated here
  9. 1996 High

    Transgenic sorting of MAP2c protein to dendrites despite somatic mRNA proved a protein-intrinsic dendritic targeting signal independent of mRNA transport; isoform comparison showed MAP2 isoforms dictate distinct microtubule spacing and process geometry.

    Evidence Transgenic mouse overexpression with mRNA/protein localization, and baculovirus isoform expression in Sf9 cells with EM cross-sections

    PMID:8627364 PMID:8868472

    Open questions at the time
    • Sequence of the protein targeting signal not identified
    • Receptor/machinery reading the targeting signal unknown
  10. 1996 High

    Comparing PKA versus cdc2 phosphorylation in vitro separated MAP2's two activities—cdc2 (microtubule-binding domain) abolishes both stabilization and nucleation, PKA (projection region) reduces only nucleation—and a co-purified MAP2 kinase was shown to release MAP2 and restore motor-driven motility.

    Evidence In vitro kinase reactions with purified PKA/cdc2 and dark-field single-microtubule observation, plus in vitro motility rescue with a co-purified MAP2 kinase

    PMID:7759496 PMID:9376363

    Open questions at the time
    • Identity of the co-purified embryonic MAP2 kinase not established
    • In vivo relevance of each phosphosite-specific effect untested
  11. 1999 Medium

    Identifying MAP2c as a MARK substrate whose microtubule-binding-domain phosphorylation detaches it from microtubules linked a specific kinase to MAP2 dynamic regulation.

    Evidence Inducible MARK1/2 expression in CHO cells with immunofluorescence and viability assays

    PMID:10542369

    Open questions at the time
    • Single-lab cell-line system; neuronal relevance not shown
    • Direct in vitro phosphorylation site not mapped here
  12. 1999 High

    Showing MAP2B directly binds the L-type Ca2+ channel alpha1 subunit and brings PKA into the channel complex extended MAP2's AKAP role to postsynaptic signaling microdomains.

    Evidence Reciprocal co-IP from brain, RIIbeta overlay binding, and in vitro direct binding

    PMID:10514522

    Open questions at the time
    • Functional effect of channel-anchored PKA on channel gating not measured
    • Microtubule-independent localization mechanism unresolved
  13. 2000 High

    PKA phosphorylation of KXGS-motif serines was shown to be sufficient to release MAP2c from microtubules and redirect it to actin-rich ruffles, mechanistically coupling the phospho-code to a microtubule-versus-actin switch.

    Evidence Live-cell imaging, detergent extraction, and Glu-substitution mutagenesis in HeLa cells

    PMID:11029056

    Open questions at the time
    • Endogenous neuronal stimulus driving this switch not identified here
    • Actin-binding interface not mapped
  14. 2000 Medium

    MAP2 was established as a multi-kinase signaling scaffold by demonstrating direct SH3-domain binding to c-Src and Grb2 via the microtubule-binding domain, with ERK2 phosphorylation disrupting the interaction; GSK3beta phosphorylation was shown to reduce microtubule binding, and PP2A identified as the major MAP2 phosphatase.

    Evidence GST-SH3 pulldowns and brain co-IP, GSK3beta co-transfection with fractionation, and okadaic-acid/cyclosporin dissection in brain slices

    PMID:10640627 PMID:10781592 PMID:10826493

    Open questions at the time
    • Downstream consequence of Src/Grb2 scaffolding on signaling output untested
    • GSK3beta and PP2A studies are single-lab
  15. 2001 High

    Mapping a discrete RTPPKSP SH3-binding motif for Fyn, with ERK2 threonine phosphorylation abolishing binding, defined a phosphorylation switch governing MAP2's recruitment of a tyrosine kinase that in turn phosphorylates MAP2.

    Evidence GST-SH3 pulldown, co-IP from human fetal brain, ELISA, and co-transfection kinase assays

    PMID:11546790

    Open questions at the time
    • Functional role of MAP2 tyrosine phosphorylation by Fyn unknown
    • Competition with other SH3 partners at the same motif not addressed here
  16. 2002 High

    The MAP2 knockout mouse proved MAP2 is required in vivo for dendritic PKA anchoring and downstream CREB signaling, as well as for microtubule density and dendrite length, consolidating its dual structural/AKAP function.

    Evidence MAP2 KO mouse with immunofluorescence, PKA-subunit Western blots, and forskolin-induced pCREB assays in cultured neurons

    PMID:12163474

    Open questions at the time
    • Transcriptional targets downstream of reduced CREB signaling not defined
    • Contribution of AKAP versus structural roles to phenotype not separated
  17. 2003 Medium

    Identifying Rho-kinase phosphorylation at Ser1796 with myosin phosphatase as its counteracting phosphatase placed MAP2 in the Rho-kinase/myosin phosphatase axis, and co-IP with the NMDA receptor complex tied MAP2 physically to its activity-dependent regulator.

    Evidence In vitro kinase assay with MS site mapping and MBS interaction, plus co-IP from hippocampal slices with pharmacological dissection of NMDA/calpain/calcium

    PMID:12834896 PMID:14535960

    Open questions at the time
    • Functional effect of Ser1796 phosphorylation on microtubule binding not measured
    • Both findings are single-lab
  18. 2005 Medium

    Linking amyloid-beta oligomers to calpain-mediated cleavage of all MAP2 isoforms via Ca2+ dysregulation and ROS connected MAP2 destruction to a disease-relevant insult.

    Evidence Abeta treatment of neurons with calpain/caspase inhibitors, antioxidants, and Western blot

    PMID:16234245

    Open questions at the time
    • Single-lab pharmacological dissection
    • In vivo relevance to Alzheimer pathology not established here
  19. 2006 Medium

    Identifying MAP2 as the receptor for the neurosteroid pregnenolone, mediating its stimulation of microtubule polymerization and neurite outgrowth, added a ligand-driven mode of MAP2 regulation.

    Evidence Binding and polymerization assays with RNAi knockdown in PC12 cells and neurite measurement

    PMID:16537405

    Open questions at the time
    • Pregnenolone-binding site on MAP2 not mapped
    • Single-lab; physiological neurosteroid concentrations not addressed
  20. 2011 Medium

    Single-molecule imaging refined the mRNA-targeting model by showing MAP2 transcripts travel in low-copy RNPs whose composition is dynamically tuned by synaptic activity and Staufen 2.

    Evidence smFISH, live imaging, Staufen 2 knockdown, and synaptic-activity manipulation

    PMID:21869818

    Open questions at the time
    • Local translation rate from these RNPs not quantified
    • Relationship to the protein-intrinsic targeting signal not reconciled
  21. 2012 Medium

    Defining PP2A/Balpha as a direct MAP2 phosphatase whose binding site overlaps the Fyn RTPPKSP motif—with Fyn and tau acting as competitors—revealed an integrated competition node coordinating phosphorylation, kinase scaffolding, and phosphatase access; concurrent work identified L1CAM as a direct MAP2c partner regulating expression via MAPK.

    Evidence Co-purification/co-IP from brain with peptide binding and competition assays, plus ELISA, co-IP, L1-knockout Westerns, and neurite outgrowth assays

    PMID:22403409 PMID:22503709

    Open questions at the time
    • In vivo significance of tau/MAP2 competition for PP2A unresolved
    • L1CAM-MAP2c structural interface not defined
  22. 2020 Medium

    Placing MAP2 in an NCAM2/14-3-3 complex required for microtubule stability and dendritic architecture extended its scaffolding role to a cell-adhesion-linked cytoskeletal module.

    Evidence Co-IP, proteomics, hippocampal-neuron knockdown with morphology, and in vivo cortical migration assay

    PMID:32043120

    Open questions at the time
    • Directness of MAP2-NCAM2 binding versus 14-3-3-bridged not resolved
    • Single-lab
  23. 2021 High

    Demonstrating that disease-associated Ser1782 hyperphosphorylation reduces microtubule binding and, as a phosphomimetic mouse, shrinks dendrites and spines while suppressing translation linked the MAP2 phospho-code directly to schizophrenia pathophysiology and a new translational-regulation function.

    Evidence Phosphoproteomics, computational modeling, S1782E transgenic mouse, co-IP/MS interactome, and protein-synthesis assays

    PMID:33526823

    Open questions at the time
    • Mechanism by which MAP2 suppresses protein synthesis not defined
    • Causal kinase for Ser1782 hyperphosphorylation in disease not identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • The molecular identity of the protein-intrinsic dendritic targeting signal and the machinery that reads it, and how the convergent kinase/phosphatase/ligand inputs are integrated in vivo to time dendritic remodeling, remain unresolved.
  • No defined sequence/receptor for protein-based dendritic targeting
  • No integrated quantitative model of competing phospho-inputs in neurons
  • Mechanism coupling MAP2 to translational control unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 6 GO:0060090 molecular adaptor activity 5 GO:0098772 molecular function regulator activity 3 GO:0008289 lipid binding 1 GO:0140299 molecular sensor activity 1
Localization
GO:0005856 cytoskeleton 5 GO:0005886 plasma membrane 2 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-112316 Neuronal System 3 R-HSA-1266738 Developmental Biology 3 R-HSA-1643685 Disease 2
Partners
CACNA1CFYNGRB2L1CAMNCAM2PPP2R2APRKAR2BSRC
Complex memberships
L-type Ca2+ channel (class C) complexNCAM2/14-3-3 complexNMDA receptor complexPKA holoenzyme (AKAP-anchored)

Evidence

Reading pass · 39 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1988 The C-terminal 185 amino acids of MAP2, containing three imperfect 18-amino-acid repeats, constitute the microtubule-binding domain. A subcloned fragment spanning the first two repeats copurified with microtubules through two successive cycles of polymerization/depolymerization, while a control polypeptide from the N-terminal region completely failed to copurify. In vitro translation of subcloned fragments followed by microtubule copurification assay Science High 3142041
1988 MAP2 is a component of crossbridges between microtubules and neurofilaments in the neuronal cytoskeleton. MAP2 bound isolated neurofilament L protein in vitro, and when tubulin was added and polymerized, neurofilaments were crosslinked with microtubules via MAP2 bridges. Quick-freeze deep-etch immunoelectron microscopy with anti-MAP2 antibody decoration, plus in vitro reconstitution with purified neurofilament L protein and tubulin The Journal of neuroscience High 3045269
1988 MAP2 mRNA is selectively localized in dendrites of developing neurons, whereas tubulin mRNA is restricted to neuronal cell bodies, establishing a dendritic targeting signal for MAP2 transcript. In situ hybridization with specific cDNA probes in developing brain tissue Nature High 3200318
1992 Expression of MAP2 is necessary for both neurite extension and cessation of cell division during neuronal differentiation; stable transfectants with MAP2 antisense RNA showed reduced MAP2 protein, failed normal morphological differentiation, and failed to withdraw from the cell cycle. Stable antisense RNA transfection in embryonal carcinoma cells with retinoic acid-induced differentiation Cell High 1997209
1992 Transfection of MAP2c or tau cDNA into fibroblasts stabilizes microtubules against depolymerizing reagents and enriches microtubules in acetylated alpha-tubulin, demonstrating that these MAPs induce post-translational modification of tubulin. cDNA transfection into fibroblasts, drug-resistance assay, immunofluorescence with anti-acetylated tubulin antibody Journal of cell science High 1487506
2002 MAP2 anchors the regulatory subunit II of cAMP-dependent protein kinase (PKA) in dendrites. MAP2-deficient mice show reduced microtubule density and dendritic length, significant reduction of PKA subunits in dendrites and total PKA, and markedly reduced phosphorylated CREB induction after forskolin stimulation. MAP2 knockout mouse analysis: immunofluorescence, Western blot for PKA subunits, pCREB induction assay in cultured neurons The Journal of cell biology High 12163474
1989 High-molecular-weight MAP2 and low-molecular-weight MAP2c are generated by alternative splicing from a single gene and share the C-terminal tubulin-binding domain and a short N-terminal sequence. MAP2c lacks 1,342 amino acids of the filamentous sidearm domain present in high-MW MAP2, and MAP2c mRNA is not present in dendrites, indicating the dendritic targeting signal is specific to the high-MW isoform. cDNA cloning, sequence comparison, in situ hybridization for mRNA localization Nature High 2770869
1995 MAP2 is prevented from entering the axon by its N-terminal projection domain. Microtubule binding of MAP2/MAP2C is tighter in the cell body and dendrites than in the axon, a property determined by the microtubule-binding domain and suggested to be regulated by phosphorylation. Transfection of tagged tau, MAP2, MAP2C, and chimeric/deletion mutants into primary cultured neurons Neuron High 7857650
1990 NMDA receptor activation induces rapid (~70%) dephosphorylation of MAP2 in hippocampal slices, blocked by competitive and noncompetitive NMDA antagonists but not non-NMDA receptor antagonists, suggesting NMDA-stimulated protein phosphatase (possibly calcineurin) dephosphorylates MAP2. 32P-orthophosphate labeling of hippocampal slices, pharmacological dissection with receptor antagonists Neuron High 2169265
1996 Glutamate produces bidirectional regulation of MAP2 phosphorylation in neurons: a rapid transient increase via metabotropic receptors (attenuated by CaMK and PKC inhibitors) followed by persistent dephosphorylation via NMDA receptor activation of calcineurin (PP2B). The phosphorylation state of MAP2 determines its interaction with microtubules and actin. 32P metabolic labeling of neurons, pharmacological dissection with receptor antagonists and kinase/phosphatase inhibitors Neuron High 8789950
1999 MAP2B (a well-established AKAP) directly binds the alpha1 subunit of class C L-type Ca2+ channels in neurons; this association is independent of microtubules. PKA is an integral part of the immunoisolated class C channel complex, and MAP2B mediates recruitment of PKA to postsynaptic sites. Co-immunoprecipitation from rat brain extracts, protein overlay binding assay with 32P-labeled RIIβ, immunoblotting, in vitro direct binding assay The Journal of biological chemistry High 10514522
1999 MARK kinases phosphorylate MAP2c on its microtubule-binding domain in transfected CHO cells, leading to detachment of MAP2c from microtubules and increased microtubule dynamic instability; prolonged MARK2 expression causes microtubule disruption and cell death. Inducible expression of MARK1/MARK2 in transfected CHO cells, immunofluorescence, cell viability assay Cell motility and the cytoskeleton Medium 10542369
2000 GSK3β phosphorylates MAP2C in co-transfected COS-1 cells, and this phosphorylation prevents microtubule bundle formation. Phosphorylated MAP2C species are enriched in cytoskeleton-unbound fractions, indicating that GSK3β-mediated phosphorylation reduces MAP2 binding to microtubules. Co-transfection of MAP2C and GSK3β (wild-type or mutant) in COS-1 cells, immunofluorescence for microtubule bundles, cytoskeletal fractionation, lithium chloride rescue European journal of cell biology Medium 10826493
2000 PKA activity disrupts the MAP2-microtubule interaction in living HeLa cells and promotes MAP2c localization to peripheral actin-rich membrane ruffles. PKA phosphorylates serines within KXGS motifs in each tubulin-binding repeat; single-site glutamic acid substitution was sufficient to disrupt microtubule binding, and double/triple mutations promoted MAP2c-actin colocalization. Live-cell imaging, detergent extraction assay, site-directed mutagenesis (Glu substitutions), immunofluorescence colocalization in HeLa cells Molecular biology of the cell High 11029056
2000 All three neuronal MAP2 isoforms bind specifically to the SH3 domains of c-Src and Grb2 via the microtubule-binding domain (not a PXXP motif). Endogenous MAP2-Src and MAP2-Grb2 interactions were confirmed by co-immunoprecipitation from brain lysate. ERK2 phosphorylation of MAP2c inhibits the MAP2-SH3 interaction. GST-SH3 pulldown assay, co-immunoprecipitation from brain lysate, in vitro kinase assay with ERK2 The Journal of biological chemistry High 10781592
2001 MAP2c binds Fyn kinase through the RTPPKSP SH3-binding motif. Fyn phosphorylates MAP2c on tyrosine. ERK2-mediated threonine phosphorylation of the RTPPKSP motif abolishes the MAP2c-Fyn interaction. Co-immunoprecipitation of Fyn and MAP2c from human fetal brain confirmed the in vivo interaction. GST-SH3 pulldown, co-immunoprecipitation from human fetal brain homogenate, ELISA binding assay, co-transfection in COS7 cells with kinase assay The Journal of biological chemistry High 11546790
1997 cdc2 kinase phosphorylation of MAP2 (>60% of phosphates in the microtubule-binding region) abolishes both microtubule-stabilizing and microtubule-nucleating activities. PKA phosphorylation (~70% in the projection region) reduces only microtubule-nucleating activity, not stabilization. These distinct effects were demonstrated by direct observation of individual microtubules. In vitro phosphorylation by purified PKA or cdc2 kinase, dark-field microscopy observation of individual microtubules, spontaneous polymerization assay Biochemistry High 9376363
2003 Rho-kinase phosphorylates MAP2 at Ser1796, and myosin phosphatase (MBS subunit) binds MAP2 and can dephosphorylate it. These were identified as novel substrates of the Rho-kinase/myosin phosphatase pathway. In vitro kinase assay, phosphorylation site mapping by mass spectrometry/sequencing, interaction assay with MBS subunit Journal of neurochemistry Medium 14535960
2000 PP2A, but not PP2B, regulates MAP2 phosphorylation at multiple sites in rat brain slices; inhibition of PP2A with okadaic acid induced phosphorylation of MAP2 and impaired its microtubule-binding activity, establishing PP2A as the major phosphatase regulating MAP2. Metabolically competent rat brain slices treated with okadaic acid (PP2A inhibitor) or cyclosporin A (PP2B inhibitor), Western blot with phospho-specific antibodies, microtubule-binding assay Brain research Medium 10640627
2012 PP2A/Bα directly binds MAP2 and dephosphorylates it. The binding site is within the microtubule-binding domain and upstream proline-rich region of MAP2c, overlapping with the RTPPKSP motif also recognized by Fyn kinase. Fyn inhibits the PP2A/Bα-MAP2 interaction; tau and MAP2 compete for binding to PP2A/Bα. Co-purification from bovine brain, co-immunoprecipitation, in vitro binding assay with peptides, competition assay, immunofluorescence colocalization The Journal of biological chemistry High 22403409
1990 The MAP2-binding and P75-binding domain in the PKA regulatory subunit RIIβ is located within its N-terminal 50 amino acids. Fusion proteins containing RIIβ amino acids 1–50 bound MAP2 and P75 immobilized on nitrocellulose; deletion of residues 1–25 or 25–96 abolished binding. Expression of truncated RIIβ-fusion proteins in E. coli, overlay binding assay on nitrocellulose filters The Journal of biological chemistry Medium 2254332
2006 MAP2 functions as a receptor for the neurosteroid pregnenolone (PREG) and its analog MePREG. PREG and MePREG bind MAP2 and stimulate microtubule polymerization. RNA interference knockdown of MAP2 prevents the stimulatory effects of PREG/MePREG on neurite extension but does not affect progesterone action. Binding assay, microtubule polymerization assay, RNA interference knockdown in PC12 cells, neurite outgrowth measurement Proceedings of the National Academy of Sciences Medium 16537405
1993 MAP2c-transfected non-neuronal cells form microtubule-containing processes specifically upon actin depolymerization with cytochalasin B. This effect is specific to MAP2c (not taxol-stabilized microtubules), suggesting MAP2c confers stability, bundling, and stiffness on microtubules enabling process outgrowth against cortical actin tension. cDNA transfection into non-neuronal cells, cytochalasin B treatment, video time-lapse microscopy Development Medium 8392463
1993 MAP2C-bundled microtubules in transfected fibroblasts are extremely stable (less than 10% tubulin exchange within 1 hour) but still incorporate exogenously introduced tubulin rapidly at distal ends, demonstrating that MAP2C stabilizes microtubule bundles while preserving plus-end assembly. Microinjection of biotin-labeled tubulin, photoactivation of caged fluorescein-labeled tubulin, immunofluorescence The Journal of cell biology High 8421058
1992 MAP2c expression in non-neuronal cells induces MTOC-independent microtubule polymerization and bundling. At higher expression levels, increasing proportions of microtubules form independently of the MTOC; MAP2c imparts both stability and stiffness to microtubules. cDNA transfection in non-neuronal cell lines, immunofluorescence, comparison with taxol and DMSO stabilization Development Medium 1338311
1994 MAP2 (but not MAP2C or tau) binds phosphatidylinositol vesicles with high affinity (Kd ~51 nM), approximately 30-fold higher than MAP2C (~1.4 µM). This high affinity requires two sites: a low-affinity site in the C-terminal domain (shared with MAP2C/tau) and a high-affinity site (~221 nM) within the MAP2-specific projection domain (absent from MAP2C due to alternative splicing). Vesicle binding assay with purified proteins, thrombin digestion of MAP2C to map binding domains Biochemistry Medium 8025110
1994 MAP2 binds to both microtubules/tubulin dimers and microfilaments/G-actin in a concentration-dependent manner. Microtubule-bound MAP2 shows diminished ability to bind microfilaments/G-actin, while microfilament-bound MAP2 efficiently binds microtubules and tubulin, suggesting an asymmetric cross-linking interaction. Solid-phase immunoassay on 96-well microtiter plates with purified proteins Biochemistry Medium 8038171
2005 Soluble amyloid-β oligomers induce proteolysis of MAP2a, MAP2b, and MAP2c through calpain activation (triggered by Ca2+ dysregulation and ROS), which on its own is sufficient to cleave all MAP2 isoforms. Antioxidants prevent MAP2 proteolysis, linking ROS to calpain-mediated MAP2 degradation. In vitro Aβ treatment of neurons, calpain inhibitor experiments, caspase-3 inhibitor experiments, Western blot The Journal of biological chemistry Medium 16234245
1994 MAP2 phosphorylation at Ser136, a Ser-Pro motif, occurs in vivo and in vitro specifically by proline-directed kinases (MAP kinase, GSK-3, cdk family members) but not by PKA, PKC, or CaMKII. After microinjection into cell lines, dephosphorylated MAP2 becomes phosphorylated at Ser136; microtubule reorganization by injected MAP2 is independent of Ser136 phosphorylation. In vitro kinase assays, site-directed mutagenesis of Ser136, monoclonal antibody epitope mapping, microinjection into cell lines European journal of cell biology High 7525290
1983 MAP2 is present in dendritic spines and colocalizes with actin at the filamentous compartment of spines, endomembranes of the spine apparatus, smooth endoplasmic reticulum, and postsynaptic density, indicating MAP2 is an actin-associated protein in dendritic spines. Immunogold electron microscopy with double-labeling using anti-MAP2 and anti-actin antibodies Proceedings of the National Academy of Sciences Medium 6572937
1995 A MAP2-associated kinase (embryonic MAP2 kinase, Mr=100,000) co-purified with chicken embryonic MAP2 phosphorylates MAP2 at serine residues and releases MAP2 from microtubules, restoring kinesin- and dynein-driven microtubule motility that is otherwise inhibited by MAP2. This kinase is cAMP-independent and distinct from cdc2 kinase, MAPK, and NIMA kinase in its ability to alter MAP2-microtubule affinity. In vitro motility assay, kinase co-purification, in vitro phosphorylation with multiple kinase comparisons The Journal of biological chemistry Medium 7759496
2003 MAP2 physically associates with the NMDA receptor complex in hippocampal neurons, demonstrated by co-immunoprecipitation. NMDA receptor activation is a prominent trigger for MAP2 breakdown; calcium influx through the NMDA receptor channel and calcium release from mitochondria trigger MAP2 degradation limited by calpain activity. Co-immunoprecipitation from hippocampal slice lysates, pharmacological dissection with NMDA receptor antagonists, calpain inhibitors, calcium chelators Brain research Medium 12834896
2011 MAP2 mRNA localizes to dendrites in distinct RNPs containing very few RNA molecules (low copy number). The number of MAP2 molecules per RNP particle is affected by synaptic activity and Staufen 2, indicating that RNP composition is dynamically regulated. Single-molecule fluorescence in situ hybridization (smFISH), live-cell imaging, Staufen 2 knockdown, synaptic activity manipulation EMBO reports Medium 21869818
2012 L1CAM (L1) directly binds MAP2c (but not MAP2a/b) through its intracellular domain, as shown by ELISA. L1 upregulates MAP2a/b/c expression in hippocampal neurons via the MAPK pathway. Deficiency in both L1 and MAP2 reduces neurite outgrowth in vitro. ELISA binding assay, co-immunoprecipitation, Western blot from L1-deficient transgenic mice, MAPK pathway inhibition, neurite outgrowth assay Molecular and cellular neurosciences Medium 22503709
2021 Hyperphosphorylation of MAP2 at Ser1782 (pS1782) in schizophrenia reduces MAP2 binding to microtubules, as confirmed by computational modeling and experimental validation. A phosphomimetic S1782E transgenic mouse shows reduced basilar dendritic length, complexity, and spine density. Overexpression of wild-type and phosphomimetic MAP2 reduces protein synthesis in vitro, and the MAP2 interactome is enriched for proteins involved in protein translation. Unbiased phosphoproteomics, computational modeling, phosphomimetic transgenic mouse (S1782E), co-immunoprecipitation/mass spectrometry for interactome, protein synthesis assay Molecular psychiatry High 33526823
1996 Juvenile MAP2c and mature MAP2 induce distinct microtubule spacing and process morphologies when expressed in Sf9 cells. MAP2c induces multiple short thin processes with variable, close microtubule spacing; mature MAP2 induces fewer, thicker processes with a proximo-distal taper in microtubule number and wider spacing, demonstrating that MAP2 isoforms serve as architectural elements establishing specific microtubule arrangements. Baculovirus-mediated expression in Sf9 cells, electron microscopy of process cross-sections Molecular biology of the cell Medium 8868472
1996 Transgenic MAP2c protein in adult mouse neurons is sorted to dendrites but not axons despite its mRNA being restricted to cell bodies, demonstrating that dendritic targeting of MAP2c depends on a signal in the protein itself, not on mRNA transport. Transgenic mouse overexpression of MAP2c, in situ hybridization for mRNA localization, immunofluorescence for protein localization The Journal of neuroscience High 8627364
1983 MAP2 binds to the Sau96.1 restriction fragment of mouse satellite DNA containing poly(dA/dT) sequences; DNase protection assay showed MAP2 protects poly(dA)4/poly(dT)4 sequences from digestion. DNA-binding assay, DNase protection experiment with MAP2-DNA complex The EMBO journal Low 10872313
2020 NCAM2 forms a protein complex with MAP2 and 14-3-3γ/ζ in neurons; NCAM2 depletion results in destabilization of the microtubular network and reduced MAP2 signal, establishing MAP2 as part of an NCAM2-dependent cytoskeletal regulatory complex for dendritic architecture. Co-immunoprecipitation, proteomic analysis, knockdown in hippocampal neurons with morphological readout, in vivo cortical migration assay Cerebral cortex Medium 32043120

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1988 Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature 1005 2842685
1988 Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites. Nature 499 3200318
1988 Microtubule-associated protein MAP2 shares a microtubule binding motif with tau protein. Science (New York, N.Y.) 463 3142041
2000 Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function. Progress in neurobiology 410 10704996
1991 Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases. Genes & development 334 1899230
1987 MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: an immunocytochemical study of cultured rat cerebrum. The Journal of neuroscience : the official journal of the Society for Neuroscience 318 2444675
1992 The role of microtubule-associated protein 2 (MAP-2) in neuronal growth, plasticity, and degeneration. Journal of neuroscience research 313 1484385
1992 Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B, MAP2 or tau. Journal of cell science 292 1487506
2002 MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction. The Journal of cell biology 287 12163474
1991 Molecular characterization of microtubule-associated proteins tau and MAP2. Trends in neurosciences 286 1713721
1991 Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America 211 1961755
1991 MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways. Nature 204 1702881
1991 Inhibition of MAP2 expression affects both morphological and cell division phenotypes of neuronal differentiation. Cell 204 1997209
1990 Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2. Neuron 202 2169265
1987 MAP2 expression and neuritic outgrowth and branching are coregulated through region-specific neuro-astroglial interactions. The Journal of neuroscience : the official journal of the Society for Neuroscience 199 2444676
1992 Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease. FEBS letters 191 1323485
1980 Microtubule-associated proteins: a monoclonal antibody to MAP2 binds to differentiated neurons. Proceedings of the National Academy of Sciences of the United States of America 189 7001466
1983 Immunocytochemical localization of actin and microtubule-associated protein MAP2 in dendritic spines. Proceedings of the National Academy of Sciences of the United States of America 186 6572937
1994 DLX-2, MASH-1, and MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrain. The Journal of neuroscience : the official journal of the Society for Neuroscience 185 7965042
1988 MAP2 is a component of crossbridges between microtubules and neurofilaments in the neuronal cytoskeleton: quick-freeze, deep-etch immunoelectron microscopy and reconstitution studies. The Journal of neuroscience : the official journal of the Society for Neuroscience 172 3045269
1989 Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau. Brain research. Developmental brain research 149 2509111
1991 ERKs, extracellular signal-regulated MAP-2 kinases. Current opinion in cell biology 142 1667578
2022 More than a marker: potential pathogenic functions of MAP2. Frontiers in molecular neuroscience 131 36187353
1990 Stimulation of MAP-2 kinase activity in T lymphocytes by anti-CD3 or anti-Ti monoclonal antibody is partially dependent on protein kinase C. Journal of immunology (Baltimore, Md. : 1950) 130 2156931
1999 Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells. Cell motility and the cytoskeleton 127 10542369
1999 The A-kinase anchor protein MAP2B and cAMP-dependent protein kinase are associated with class C L-type calcium channels in neurons. The Journal of biological chemistry 122 10514522
1996 Postsynaptic mechanisms for bidirectional control of MAP2 phosphorylation by glutamate receptors. Neuron 117 8789950
1989 Embryonic MAP2 lacks the cross-linking sidearm sequences and dendritic targeting signal of adult MAP2. Nature 116 2770869
1995 Sorting mechanisms of tau and MAP2 in neurons: suppressed axonal transit of MAP2 and locally regulated microtubule binding. Neuron 115 7857650
2005 Altered expression of MAP-2, GAP-43, and synaptophysin in the hippocampus of rats with chronic cerebral hypoperfusion correlates with cognitive impairment. Brain research. Molecular brain research 111 15964096
1993 Actin depolymerisation induces process formation on MAP2-transfected non-neuronal cells. Development (Cambridge, England) 110 8392463
2000 Phosphorylation-dependent localization of microtubule-associated protein MAP2c to the actin cytoskeleton. Molecular biology of the cell 106 11029056
1997 Expression of microtubule-associated proteins MAP2 and tau in cultured rat brain oligodendrocytes. Cell and tissue research 106 9082959
1988 A 70-kilodalton microtubule-associated protein (MAP2c), related to MAP2. Journal of neurochemistry 104 3121794
2005 Microtubule-associated protein MAP1A, MAP1B, and MAP2 proteolysis during soluble amyloid beta-peptide-induced neuronal apoptosis. Synergistic involvement of calpain and caspase-3. The Journal of biological chemistry 103 16234245
2003 Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase. Journal of neurochemistry 102 14535960
1992 Reorganisation of the microtubular cytoskeleton by embryonic microtubule-associated protein 2 (MAP2c). Development (Cambridge, England) 102 1338311
2019 Proteomics in cerebrospinal fluid and spinal cord suggests UCHL1, MAP2 and GPNMB as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis. Acta neuropathologica 95 31701227
2006 Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor. Proceedings of the National Academy of Sciences of the United States of America 93 16537405
1989 Distribution of MAP2 in dendritic spines and its colocalization with actin. An immunogold electron-microscope study. Cell and tissue research 90 2743390
2011 Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers. EMBO reports 87 21869818
1993 An isoform of microtubule-associated protein 2 (MAP2) containing four repeats of the tubulin-binding motif. Journal of cell science 87 8282767
1986 Brain-specific expression of MAP2 detected using a cloned cDNA probe. The Journal of cell biology 87 2423532
1986 Expression and distribution of microtubule-associated protein 2 (MAP2) in neuroblastoma and primary neuronal cells. Brain research 87 3512042
2000 GSK3beta-mediated phosphorylation of the microtubule-associated protein 2C (MAP2C) prevents microtubule bundling. European journal of cell biology 78 10826493
1996 Diminished microtubule-associated protein 2 (MAP2) immunoreactivity following cortical impact brain injury. Journal of neurotrauma 76 8965322
1998 Making sense of the multiple MAP-2 transcripts and their role in the neuron. Molecular neurobiology 74 9588626
2000 Regulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: evidence for MAP2 as a scaffolding protein. The Journal of biological chemistry 73 10781592
1997 Phosphorylation states of microtubule-associated protein 2 (MAP2) determine the regulatory role of MAP2 in microtubule dynamics. Biochemistry 72 9376363
1994 Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. Neuroscience letters 70 7891887
2000 Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. Brain research 68 10640627
2012 The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. The Journal of biological chemistry 66 22403409
1990 Identification of the MAP2- and P75-binding domain in the regulatory subunit (RII beta) of type II cAMP-dependent protein kinase. Cloning and expression of the cDNA for bovine brain RII beta. The Journal of biological chemistry 65 2254332
1991 MAP2: a sensitive cross-linker and adjustable spacer in dendritic architecture. FEBS letters 64 1765166
1995 Changes of MAP2 phosphorylation during brain development. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 62 8537643
1993 Dynamics of microtubules bundled by microtubule associated protein 2C (MAP2C). The Journal of cell biology 61 8421058
2003 Microtubule-associated protein 2 (MAP2) associates with the NMDA receptor and is spatially redistributed within rat hippocampal neurons after oxygen-glucose deprivation. Brain research 60 12834896
1986 Ontogenesis of microtubule-associated protein 2 (MAP2) in embryonic mouse cortex. Brain research 58 3524754
1994 Phosphorylation of microtubule-associated proteins MAP2a,b and MAP2c at Ser136 by proline-directed kinases in vivo and in vitro. European journal of cell biology 57 7525290
2017 The role of MAP2 kinases and p38 kinase in acute murine liver injury models. Cell death & disease 56 28661486
2007 Calcium-dependent NMDA-induced dendritic injury and MAP2 loss in acute hippocampal slices. Neuroscience 52 17239543
1992 Domain structure and antiparallel dimers of microtubule-associated protein 2 (MAP2). Journal of structural biology 50 1373291
2019 Structure and Functions of Microtubule Associated Proteins Tau and MAP2c: Similarities and Differences. Biomolecules 49 30884818
2016 Spatiotemporal profile of Map2 and microglial changes in the hippocampal CA1 region following pilocarpine-induced status epilepticus. Scientific reports 48 27143585
2004 Neuronal-associated microtubule proteins class III beta-tubulin and MAP2c in neuroblastoma: role in resistance to microtubule-targeted drugs. Molecular cancer therapeutics 48 15367708
1988 Phylogenetic conservation of brain microtubule-associated proteins MAP2 and tau. Neuroscience 48 3143928
1983 Microtubule-associated protein MAP2 preferentially binds to a dA/dT sequence present in mouse satellite DNA. The EMBO journal 48 10872313
1995 Microtubule-associated proteins in developing oligodendrocytes: transient expression of a MAP2c isoform in oligodendrocyte precursors. Journal of neuroscience research 47 8847742
2001 Distribution of map2 in hippocampus and cerebellum of young and old rats by quantitative immunohistochemistry. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 46 11457938
1986 Microtubule-associated protein 2 (MAP2) is present in astrocytes of the optic nerve but absent from astrocytes of the optic tract. The Journal of neuroscience : the official journal of the Society for Neuroscience 46 3712008
2003 Chromosome 2 deletion encompassing the MAP2 gene in a patient with autism and Rett-like features. Clinical genetics 45 14986829
1993 Platelet-activating factor triggers the phosphorylation and activation of MAP-2 kinase and S6 peptide kinase activity in human B cell lines. Journal of immunology (Baltimore, Md. : 1950) 45 7688385
1996 MAP2a, an alternatively spliced variant of microtubule-associated protein 2. Journal of neurochemistry 44 8769894
1991 Regulation of microtubule associated protein 2 (MAP2) expression by nerve growth factor in PC12 cells. Experimental cell research 44 2026175
2001 Binding of Fyn to MAP-2c through an SH3 binding domain. Regulation of the interaction by ERK2. The Journal of biological chemistry 43 11546790
1995 Developmental regulation of MAP2 variants during neuronal differentiation in vitro. Brain research. Developmental brain research 42 8612323
2000 Increased dendritic MAP2 expression in the hippocampus in schizophrenia. Schizophrenia research 41 10708340
1997 Experience-dependent modifications in MAP2 phosphorylation in rat olfactory bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience 40 9391014
2010 Chronic restraint stress alters the expression and distribution of phosphorylated tau and MAP2 in cortex and hippocampus of rat brain. Brain research 39 20513368
2005 Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli. Cellular signalling 39 16014325
1997 Neuronal damage and MAP2 changes induced by the glutamate transport inhibitor dihydrokainate and by kainate in rat hippocampus in vivo. Experimental brain research 39 9372295
1993 Acute anoxia-induced alterations in MAP2 immunoreactivity and neuronal morphology in rat hippocampus. Brain research 39 8369956
2024 Diagnostic Performance of GFAP, UCH-L1, and MAP-2 Within 30 and 60 Minutes of Traumatic Brain Injury. JAMA network open 38 39230905
2012 L1CAM increases MAP2 expression via the MAPK pathway to promote neurite outgrowth. Molecular and cellular neurosciences 38 22503709
1996 Juvenile and mature MAP2 isoforms induce distinct patterns of process outgrowth. Molecular biology of the cell 38 8868472
1997 Age-dependent organotypic expression of microtubule-associated proteins (MAP1, MAP2, and MAP5) in rat brain. Neurochemical research 37 9178955
1994 The difference in the binding of phosphatidylinositol distinguishes MAP2 from MAP2C and Tau. Biochemistry 36 8025110
1994 Interactions of microtubule-associated protein MAP2 with unpolymerized and polymerized tubulin and actin using a 96-well microtiter plate solid-phase immunoassay. Biochemistry 36 8038171
2006 Changes in microtubule-associated protein-2 (MAP2) expression during development and after status epilepticus in the immature rat hippocampus. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 35 17229541
2010 Compression alters kinase and phosphatase activity and tau and MAP2 phosphorylation transiently while inducing the fast adaptive dendritic remodeling of underlying cortical neurons. Journal of neurotrauma 34 20568963
2005 Microtubule-associated protein 2 (MAP2)--a promising approach to diagnosis of forensic types of hypoxia-ischemia. Acta neuropathologica 34 16328528
1995 A microtubule-associated protein (MAP2) kinase restores microtubule motility in embryonic brain. The Journal of biological chemistry 34 7759496
2000 MAP2 and neurogranin as markers for dendritic lesions in CNS injury. An immunohistochemical study in the rat. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 33 10737454
2009 Oncogenic BRAFV600E induces expression of neuronal differentiation marker MAP2 in melanoma cells by promoter demethylation and down-regulation of transcription repressor HES1. The Journal of biological chemistry 32 19880519
2006 Transcriptional regulation of human MAP2 gene in melanoma: role of neuronal bHLH factors and Notch1 signaling. Nucleic acids research 32 16916793
1996 Transgenic expression of embryonic MAP2 in adult mouse brain: implications for neuronal polarization. The Journal of neuroscience : the official journal of the Society for Neuroscience 32 8627364
2023 Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology. Scientific reports 31 37258650
2021 MAP2 is differentially phosphorylated in schizophrenia, altering its function. Molecular psychiatry 31 33526823
2020 NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3. Cerebral cortex (New York, N.Y. : 1991) 31 32043120
2018 miR-484/MAP2/c-Myc-positive regulatory loop in glioma promotes tumor-initiating properties through ERK1/2 signaling. Journal of molecular histology 31 29480405

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