Affinage

LTBP1

Latent-transforming growth factor beta-binding protein 1 · UniProt Q14766

Length
1721 aa
Mass
186.8 kDa
Annotated
2026-06-10
56 papers in source corpus 19 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LTBP1 is a large extracellular matrix glycoprotein that controls the latency, matrix sequestration, and activation of TGF-β by covalently tethering the latent cytokine to the ECM. Its third 8-Cys (TB3) domain forms a covalent disulfide-exchange bond with Cys33 of the TGF-β1 LAP propeptide — the first demonstrated case of an extracellular module exchanging cysteine disulfide bonds with a heterologous ligand — a reaction enabled by a TB3-specific two-residue insertion that exposes the exchangeable 2nd–6th cysteine bond (PMID:8617200, PMID:14607119). Multiple N-terminal and internal 8-Cys domains independently anchor LTBP1 to fibroblast matrix (PMID:11112702), and the protein co-localizes with fibrillin microfibrils, binding fibrillin-1 through a Ca²⁺-dependent C-terminal site shared with LTBP-2, thereby targeting latent TGF-β to the microfibrillar apparatus as a tissue repository (PMID:17293099, PMID:9764833). Beyond TGF-β sequestration, LTBP1 independently promotes incorporation of fibrillin-1 and fibrillin-2 into the ECM, a function differing between the LTBP-1S and LTBP-1L isoforms (PMID:35452817). Latent TGF-β is mobilized either by MT1-MMP (MMP-14) proteolysis of matrix-bound LTBP1 (PMID:18602101) or by integrin αvβ6 acting on a 24-residue hinge sequence whose activity requires fibronectin and the α5β1 receptor as matrix co-factors (PMID:16260650). LTBP1 abundance is further set post-translationally: AMPK-activated PTPS drives iNOS-mediated S-nitrosylation and proteasomal degradation under hypoxia (PMID:31628042), SMURF1-mediated ubiquitination targets it for degradation and is antagonized by MCCC2 (PMID:42251191), and KAT8-mediated lactylation at K752 promotes collagen production (PMID:39102921). Transcription is epigenetically repressed by AhR-recruited HDAC2 at the Ltbp-1 promoter (PMID:18508077), and the EGF repeats are O-glucosylated by POGLUT2/3 (PMID:34411563).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 1996 High

    Established the molecular basis by which LTBP1 captures latent TGF-β, showing the TB3 domain forms a covalent bond with the LAP propeptide rather than a non-covalent association.

    Evidence Co-expression of TGF-β1 and LTBP-1 fragments in mammalian cells with immunoblotting and mutagenesis of LAP Cys33

    PMID:8617200

    Open questions at the time
    • Did not resolve the structural feature making the TB3 bond exchangeable
    • Did not map the ECM-anchoring determinants beyond the N-terminal region
  2. 1999 Medium

    Resolved why LTBP1 exists in two forms by mapping independent cell-type-specific promoters generating LTBP-1L and LTBP-1S, and showed TGF-β1 induction is post-transcriptional.

    Evidence Genomic sequencing, reporter gene deletion constructs, Northern blotting, promoter mapping

    PMID:10551816

    Open questions at the time
    • Functional differences between isoforms not defined
    • Post-transcriptional mechanism of TGF-β induction not identified
  3. 2000 Medium

    Characterized post-translational modification of the TB3 region, identifying a conserved N-glycosylation site bearing complex/hybrid glycans.

    Evidence MALDI-TOF mass spectrometry and enzymatic glycan analysis in insect cell expression

    PMID:10677208

    Open questions at the time
    • Functional consequence of glycosylation for LAP binding untested
    • Insect-cell glycans may not reflect mammalian processing
  4. 2001 High

    Defined how LTBP1 is anchored in the matrix, showing three distinct 8-Cys domains independently and strongly bind fibroblast ECM.

    Evidence Recombinant fragment binding to fibroblast matrices, competitive inhibition, deoxycholate-resistance assays

    PMID:11112702

    Open questions at the time
    • Specific ECM ligands of each domain not identified
    • Nature of the deoxycholate-resistant bond not biochemically defined
  5. 2002 Medium

    Revealed a non-covalent mode of TGF-β family modulation, showing LTBP-1 potentiates activin/nodal in development without requiring covalent binding.

    Evidence Xenopus animal cap assays, in situ hybridization, conditioned medium experiments

    PMID:12142025

    Open questions at the time
    • Mechanism of non-covalent potentiation unknown
    • Relevance to mammalian LTBP1 not established
  6. 2003 High

    Explained at atomic resolution why TB3 alone among LTBP1 8-Cys domains exchanges disulfides, attributing it to a two-residue insertion exposing the 2nd–6th cysteine bond.

    Evidence NMR solution structure with site-directed mutagenesis and homology modelling

    PMID:14607119

    Open questions at the time
    • Structure of the TB3-LAP covalent complex not solved
    • Role of the surrounding charged ring in ligand selection untested
  7. 2005 High

    Identified the activation determinant, showing a 24-aa hinge sequence mediates integrin αvβ6 activation of latent TGF-β and requires fibronectin as a matrix co-factor.

    Evidence Peptide binding, fibronectin-null and α5β1-deficient cell activation and matrix incorporation assays

    PMID:16260650

    Open questions at the time
    • Mechanical vs conformational mode of integrin activation not resolved
    • How fibronectin physically positions the hinge unclear
  8. 2006 Medium

    Linked LTBP1 to proteolytic activation pathways, showing its knockdown reduces active TGF-β1 via plasmin, elastase, thrombospondin-1, and MMP-2 activities.

    Evidence siRNA knockdown in mouse embryonic fibroblasts with protease activity assays and inhibitors

    PMID:16187295

    Open questions at the time
    • Direct vs indirect coupling to each protease not distinguished
    • Mechanism by which LTBP1 modulates protease activity unknown
  9. 2007 Medium

    Mapped the LTBP1-fibrillin interaction, locating the major fibrillin-1 binding site near the LTBP1 C-terminus and showing LTBP-1 and LTBP-2 compete for an overlapping site.

    Evidence Solid phase and competitive binding assays with recombinant fragments and Ca²⁺/EDTA manipulation

    PMID:17293099

    Open questions at the time
    • Single-lab in vitro binding without cellular confirmation
    • Functional consequence of LTBP-1/LTBP-2 competition in vivo unknown
  10. 2008 High

    Identified a protease that releases matrix-bound latent TGF-β, showing MT1-MMP processing of LTBP-1 via PKC/ERK signaling mediates release from subendothelial matrix.

    Evidence shRNA silencing of MT1-MMP, TIMP and uPA/plasmin inhibitors, endothelial PMA activation assays

    PMID:18602101

    Open questions at the time
    • Exact MT1-MMP cleavage sites in LTBP-1 not mapped
    • In vivo relevance beyond endothelial cells untested
  11. 2008 High

    Defined transcriptional control of LTBP1, showing AhR represses Ltbp-1 by recruiting HDAC2 and blocking pCREB1 binding at the promoter.

    Evidence ChIP, RNAi, reporter assays, AhR overexpression, promoter mutagenesis

    PMID:18508077

    Open questions at the time
    • Physiological signals driving AhR occupancy not defined
    • Downstream consequences for TGF-β output not quantified
  12. 2014 Medium

    Provided a dynamic structural picture, showing the LTBP1 C-terminal domains are connected by flexible linkers unlike rigid fibrillin, a 'knotted rope' architecture.

    Evidence NMR spectroscopy with 15N relaxation on overlapping C-terminal fragments

    PMID:24489852

    Open questions at the time
    • Functional role of flexibility in ECM binding inferred, not demonstrated
    • Full-length conformation not determined
  13. 2019 High

    Uncovered hypoxic post-translational regulation, showing AMPK-phosphorylated PTPS drives iNOS-mediated S-nitrosylation and proteasomal degradation of LTBP1 to limit TGF-β secretion.

    Evidence Co-IP, S-nitrosylation assays, AMPK kinase assays, proteasome inhibition under hypoxia

    PMID:31628042

    Open questions at the time
    • S-nitrosylation site(s) on LTBP1 not mapped
    • Which E3 ligase executes degradation not identified
  14. 2021 Medium

    Identified enzymes modifying LTBP1 EGF repeats, showing POGLUT2/3 O-glucosylate over half its EGF repeats and distinguish folded from unfolded domains.

    Evidence Mass spectrometry of O-glucosylation sites and POGLUT2/3 knockout HEK293T secretion assays

    PMID:34411563

    Open questions at the time
    • LTBP1 secretion phenotype shown for FBN1, not directly for LTBP1
    • Effect of O-glucosylation on TGF-β sequestration untested
  15. 2022 Medium

    Established a TGF-β-independent role, showing LTBP1 promotes fibrillin-1/2 incorporation into the ECM with isoform-specific activity.

    Evidence In vitro fibrillin incorporation assays comparing LTBP-1S vs LTBP-1L, ECM fractionation

    PMID:35452817

    Open questions at the time
    • Molecular basis of isoform difference not defined
    • In vivo contribution to microfibril assembly not confirmed
  16. 2024 Medium

    Revealed metabolic regulation by lactylation, showing lactate uptake via MCT1 drives KAT8-mediated LTBP1 K752 lactylation that increases collagen I/III.

    Evidence Western blotting, lactylation site mapping, KAT8 inhibition, MCT1 assays, PLLA treatment in vitro and in aged mouse skin

    PMID:39102921

    Open questions at the time
    • Mechanistic link between K752 lactylation and collagen induction unclear
    • Single-lab study without independent confirmation
  17. 2025 Medium

    Identified nuclear post-transcriptional control, showing LTA4H phosphorylates HNRNPA1 to inhibit Ltbp1 mRNA processing, with LTA4H loss raising LTBP1 and TGF-β to drive macrophage polarization.

    Evidence Co-IP of LTA4H/HNRNPA1, phosphorylation and nuclear mRNA processing assays, TGF-β and macrophage polarization assays

    PMID:40056904

    Open questions at the time
    • Direct HNRNPA1 binding sites on Ltbp1 pre-mRNA not mapped
    • Single-lab study
  18. 2026 Medium

    Identified a stabilizer of LTBP1, showing MCCC2 directly binds LTBP1 and competitively blocks SMURF1-mediated ubiquitination to activate TGF-β and promote prostate cancer bone metastasis.

    Evidence LC-MS, reciprocal Co-IP, GST pulldown, ubiquitination assays, migration/invasion and in vivo bone metastasis models

    PMID:42251191

    Open questions at the time
    • SMURF1 ubiquitination sites on LTBP1 not mapped
    • Single-lab study

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how the many post-translational and transcriptional inputs (S-nitrosylation, ubiquitination, lactylation, O-glucosylation, AhR/HDAC2 repression) are integrated to set LTBP1 levels and tune TGF-β bioavailability in specific tissues.
  • No unified quantitative model of LTBP1 regulation
  • Tissue-specific hierarchy among regulators undefined
  • Structure of the LTBP1-latent TGF-β-fibrillin matrix complex not solved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0140313 molecular sequestering activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0031012 extracellular matrix 3 GO:0005576 extracellular region 2
Pathway
R-HSA-1474244 Extracellular matrix organization 3 R-HSA-162582 Signal Transduction 3
Partners
FBN1FN1ITGB6LTBP2MCCC2MMP14SMURF1TGFB1
Complex memberships
PTPS/iNOS/LTBP1 complexfibrillin microfibrilslarge latent TGF-β complex

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 The third 8-Cys (TB3) repeat of LTBP-1 binds covalently to the LAP region of TGF-β1 via disulfide bond exchange; specifically, Cys33 of β1-LAP is required for the covalent association. The N-terminal region (first ~400 aa) of LTBP-1 associates covalently with the ECM. This was the first demonstration of an extracellular protein module capable of exchanging cysteine disulfide bonds with a heterologous ligand. Co-expression of TGF-β1 and LTBP-1 fragments in mammalian cells with signal peptide constructs, immunoblotting of secreted fusion protein complexes, site-directed mutagenesis of LAP Cys33 The EMBO journal High 8617200
2003 NMR solution structure of TB3 from LTBP-1 reveals that a two-residue insertion (absent in fibrillin-1 TB domains) increases solvent accessibility of the disulfide bond linking the 2nd and 6th cysteines, making it the exchangeable bond responsible for covalent LAP association. Site-directed mutagenesis confirmed this is the only disulfide that can be removed without perturbing the TB domain fold. A ring of negatively charged residues surrounds this disulfide. NMR solution structure determination, site-directed mutagenesis, homology modelling of TB3 isoforms Journal of molecular biology High 14607119
2001 LTBP-1 contains three distinct ECM-interacting domains: regions containing the first (hybrid) 8-Cys domain, the second 8-Cys domain, and the fourth 8-Cys domain each independently bind fibroblast ECM. N-terminal fragments bind more readily. Each fragment can competitively inhibit association of native LTBP-1 with the ECM, and binding resists sodium deoxycholate treatment suggesting strong/covalent interactions. Recombinant fragment production in mammalian expression system, binding assays to cultured fibroblast ECM and isolated matrices, competitive inhibition assays, sodium deoxycholate resistance assay Journal of cell science High 11112702
2005 A 24 amino acid sequence in the hinge domain of LTBP-1 is required for integrin αvβ6-mediated activation of latent TGF-β. This hinge region associates with fibronectin. Fibronectin-null cells minimally activate latent TGF-β and poorly incorporate the active hinge sequence into their matrix. Cells lacking the fibronectin receptor α5β1 also exhibit defective αvβ6-mediated latent TGF-β activation and decreased matrix incorporation of LTBP-1. Peptide binding assays, cell-based activation assays using fibronectin-null cells and α5β1-deficient cells, matrix incorporation assays FASEB journal High 16260650
2008 MT1-MMP (MMP-14) proteolytically processes ECM-bound LTBP-1 to release latent TGF-β complexes from the subendothelial matrix. This process requires PKC and ERK1/2 signaling and is coupled to PMA-induced MT1-MMP expression upregulation. Neither secreted MMPs nor the uPA/plasmin system contributed to LTBP-1 release. Lentiviral shRNA gene silencing of MT1-MMP, metalloproteinase inhibitors (TIMP-2, TIMP-3, TIMP-1), uPA/plasmin inhibitors, endothelial cell PMA activation assays Experimental cell research High 18602101
2007 LTBP-1 and LTBP-2 compete for binding to the same or closely adjacent site on the amino-terminal region of fibrillin-1. The major fibrillin-1 binding site on LTBP-1 resides near its C-terminus. The interaction is Ca²⁺-dependent (abolished by EDTA). A C-terminal fragment of LTBP-2 blocked LTBP-1 binding to fibrillin-1 and vice versa, indicating overlapping binding sites. Solid phase binding assays, overlay blotting, competitive binding assays with recombinant C-terminal fragments, EDTA/Ca²⁺ manipulation Matrix biology Medium 17293099
2019 Under hypoxia, AMPK phosphorylates PTPS at Thr58, which promotes PTPS binding to LTBP1 and drives iNOS-mediated S-nitrosylation of LTBP1 within a PTPS/iNOS/LTBP1 complex. LTBP1 S-nitrosylation leads to proteasome-dependent LTBP1 protein degradation, impairing TGF-β secretion and thereby maintaining tumor cell growth. Co-immunoprecipitation to identify PTPS-LTBP1 complex, S-nitrosylation assays, proteasome inhibitor experiments, AMPK kinase assays, LTBP1 stability assays under hypoxia Molecular cell High 31628042
2000 The third 8-Cys (CR3) domain of LTBP-1 contains a conserved N-glycosylation site that is modified with complex and hybrid glycans. Glycosylation status was characterized by MALDI-TOF mass spectrometry and enzymatic analysis in insect cell expression systems. MALDI-TOF mass spectrometry, enzymatic glycan analysis, recombinant protein expression in Sf9 and High-Five insect cells Biochemistry Medium 10677208
2006 LTBP-1 contributes to TGF-β1 activation in mouse embryonic fibroblasts by influencing the activities of plasminogen activator/plasmin, elastase, and thrombospondin-1, and by modulating MMP-2 activity. siRNA knockdown of LTBP-1 reduced active TGF-β1 levels and reduced PA/plasmin and elastase activities without significantly affecting their mRNA levels. siRNA knockdown of LTBP-1, TGF-β1 neutralizing antibody, recombinant TGF-β1 addition, protease activity assays, protease-specific inhibitors Journal of cellular biochemistry Medium 16187295
2008 AhR (dioxin receptor) represses Ltbp-1 transcription by recruiting HDAC2 to the Ltbp-1 promoter, which maintains histone deacetylation and prevents pCREB1(Ser133) binding. In AhR-null cells, absence of HDAC2 at the promoter and increased pCREB1 binding leads to Ltbp-1 overexpression. HDAC2 siRNA increased Ltbp-1 expression and histone acetylation in AhR-expressing cells. Chromatin immunoprecipitation (ChIP), RNA interference (RNAi/siRNA), reporter gene assays, AhR overexpression, site-directed mutagenesis of promoter elements Journal of molecular biology High 18508077
2021 POGLUT2 and POGLUT3 O-glucosylate over half of the EGF repeats on LTBP1 (as well as fibrillin-1 and -2). These enzymes can distinguish folded versus unfolded EGF repeats. O-glucosylation by POGLUT2/3 plays a role in secretion of fibrillin-1; reduced secretion was observed in single and double knockout cells. Mass spectrometry analysis of O-glucosylation sites, POGLUT2/POGLUT3 single and double knockout HEK293T cells, in vitro secretion assays The Journal of biological chemistry Medium 34411563
2022 LTBP1 promotes the incorporation of fibrillin-1 and fibrillin-2 into the extracellular matrix in vitro. This function is differentially exerted by the two isoforms (LTBP-1S and LTBP-1L), revealing a TGF-β-independent function of LTBP1 in ECM assembly. In vitro cell culture assays of fibrillin incorporation, comparison of LTBP1S vs LTBP1L isoform activities, ECM fractionation Matrix biology Medium 35452817
2014 NMR spectroscopic analysis of the LTBP1 C-terminus reveals that the four canonical domains (cbEGF14, TB3, EGF3, cbEGF15) adopt canonical folds but largely lack the rigid interdomain interactions seen in fibrillin; three interdomain regions act as flexible linkers allowing wide motion. The EGF3-cbEGF15 pair has a well-defined interdomain interface. This 'knotted rope' flexibility may facilitate ECM interactions and accessibility to proteases. NMR spectroscopy of overlapping C-terminal LTBP1 fragments, 15N relaxation studies for domain dynamics PloS one Medium 24489852
2024 Lactate released from PLLA is taken up by fibroblasts via MCT1, leading to KAT8-mediated lactylation of LTBP1 at lysine 752 (K752), which increases collagen I and collagen III protein levels in fibroblasts. Western blotting, immunofluorescence, lactylation site mapping, KAT8 inhibition, MCT1 transporter assays, PLLA treatment of fibroblasts and aged mouse skin International journal of biological macromolecules Medium 39102921
2002 Xenopus LTBP-1 (xLTBP-1) is expressed in the Spemann organizer and potentiates the activity of activin and nodal in animal cap assays. The potentiation did not require covalent association with activin, as conditioned medium containing both activin and LTBP-1 enhanced activin's effect, suggesting LTBP-1 can non-covalently modulate TGF-β family member activity. Xenopus animal cap assay, in situ hybridization for spatial expression, conditioned medium experiments Developmental biology Medium 12142025
2026 MCCC2 directly interacts with LTBP1 (identified by LC-MS, validated by Co-IP and GST pulldown). MCCC2 competitively inhibits SMURF1-mediated ubiquitination and degradation of LTBP1, thereby stabilizing LTBP1 and activating TGF-β signaling to promote prostate cancer bone metastasis. Liquid chromatography-mass spectrometry, co-immunoprecipitation, GST pulldown assay, ubiquitination assay, in vitro migration/invasion assays, in vivo bone metastasis models Oncogene Medium 42251191
1998 LTBP-1 co-localizes with fibrillin-containing microfibrils in normal human skin and localizes to these structures even during early de novo formation of the microfibrillar apparatus in skin regenerating from keratinocyte autografts. This establishes LTBP-1 as a component of fibrillin microfibrils and shows it targets latent TGF-β1 to the cutaneous microfibrillar apparatus as a repository. Immunohistochemistry and immunofluorescence localization in normal and regenerating human skin, co-localization with fibrillin antibodies The Journal of investigative dermatology Medium 9764833
2025 LTA4H induces HNRNPA1 phosphorylation, enhancing LTA4H-HNRNPA1 interaction and functionally inhibiting HNRNPA1's role in regulating Ltbp1 mRNA maturation and processing in the nucleus. LTA4H deficiency upregulates LTBP1 expression and downstream TGF-β secretion/activation, promoting CD206+ macrophage polarization. Co-immunoprecipitation of LTA4H and HNRNPA1, phosphorylation assays, nuclear mRNA processing assays, TGF-β secretion/activation assays, macrophage polarization assays Cell reports. Medicine Medium 40056904
2024 In IPF lung tissue, fibulin-1 co-localizes with both OPG and LTBP1; proximity ligation assays confirmed close proximity of fibulin-1 to LTBP1 but NOT of OPG directly to LTBP1, suggesting fibulin-1 bridges OPG and LTBP1 in a trimeric ECM complex in interstitial lung tissue. Immunofluorescence co-localization, proximity ligation assay in IPF and control lung tissue, fibulin-1 knockout mouse tissue analysis bioRxivpreprint Low
1999 Two LTBP-1 isoforms (LTBP-1L and LTBP-1S) are transcribed from independent functional promoters in a cell type-specific manner. LTBP-1L uses an upstream promoter while LTBP-1S uses a downstream one; LTBP-1L transcript is alternatively spliced into an internal splice acceptor inside exon 1 of LTBP-1S. TGF-β1 induction of LTBP-1 isoforms appears to occur by post-transcriptional mechanisms, since TGF-β1 failed to stimulate LTBP-1 reporter gene constructs. Genomic sequencing, reporter gene analysis with deletion constructs, Northern blotting, promoter mapping The Journal of biological chemistry Medium 10551816

Source papers

Stage 0 corpus · 56 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1996 Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1. The EMBO journal 187 8617200
2005 Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 144 16260650
2008 MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1. Experimental cell research 126 18602101
2007 LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein. Matrix biology : journal of the International Society for Matrix Biology 113 17293099
2001 Latent TGF-beta binding protein LTBP-1 contains three potential extracellular matrix interacting domains. Journal of cell science 87 11112702
1998 The cutaneous microfibrillar apparatus contains latent transforming growth factor-beta binding protein-1 (LTBP-1) and is a repository for latent TGF-beta1. The Journal of investigative dermatology 68 9764833
2019 PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia. Molecular cell 46 31628042
1999 Independent promoters regulate the expression of two amino terminally distinct forms of latent transforming growth factor-beta binding protein-1 (LTBP-1) in a cell type-specific manner. The Journal of biological chemistry 46 10551816
2014 Marek's disease virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-β signaling pathway. Virology 45 25528440
2003 Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta. Journal of molecular biology 45 14607119
2004 Overexpression of latent transforming growth factor-beta binding protein 1 (LTBP-1) in dioxin receptor-null mouse embryo fibroblasts. Journal of cell science 44 14762110
1999 Vitamin D3 metabolites regulate LTBP1 and latent TGF-beta1 expression and latent TGF-beta1 incorporation in the extracellular matrix of chondrocytes. Journal of cellular biochemistry 43 10025676
2024 Lactate triggers KAT8-mediated LTBP1 lactylation at lysine 752 to promote skin rejuvenation by inducing collagen synthesis in fibroblasts. International journal of biological macromolecules 35 39102921
2020 LTBP1 promotes esophageal squamous cell carcinoma progression through epithelial-mesenchymal transition and cancer-associated fibroblasts transformation. Journal of translational medicine 35 32216815
2008 Recruitment of CREB1 and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its constitutive expression in a dioxin receptor-dependent manner. Journal of molecular biology 33 18508077
2006 LTBP-1 blockade in dioxin receptor-null mouse embryo fibroblasts decreases TGF-beta activity: Role of extracellular proteases plasmin and elastase. Journal of cellular biochemistry 31 16187295
2000 Hybrid and complex glycans are linked to the conserved N-glycosylation site of the third eight-cysteine domain of LTBP-1 in insect cells. Biochemistry 30 10677208
2001 Overexpression of latent transforming growth factor-beta 1 (TGF-beta 1) binding protein 1 (LTBP-1) in association with TGF-beta 1 in ovarian carcinoma. Japanese journal of cancer research : Gann 28 11376559
2010 Tgfbeta2 and 3 are coexpressed with their extracellular regulator Ltbp1 in the early limb bud and modulate mesodermal outgrowth and BMP signaling in chicken embryos. BMC developmental biology 27 20565961
2002 The latent-TGFbeta-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signaling. Developmental biology 24 12142025
2021 POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1. The Journal of biological chemistry 23 34411563
2003 Immunohistochemical study of chondrolipoma: possible importance of transforming growth factor (TGF)-betas, latent TGF-beta binding protein-1 (LTBP-1), and bone morphogenetic protein (BMP) for chondrogenesis in lipoma. The Journal of dermatology 23 12692354
2000 [Latent TGF-beta 1 binding protein (LTBP-1); a new marker for intra-and extraocular PEX deposits]. Klinische Monatsblatter fur Augenheilkunde 22 10919121
2020 LTBP1 plays a potential bridge between depressive disorder and glioblastoma. Journal of translational medicine 20 33059753
2003 Molecular cloning of the mouse Ltbp-1 gene reveals tissue specific expression of alternatively spliced forms. Gene 18 12711388
1999 Immunolocalization of latent transforming growth factor-beta binding protein-1 (LTBP1) during mouse development: possible roles in epithelial and mesenchymal cytodifferentiation. Cell and tissue research 18 9931372
2022 LTBP1 promotes fibrillin incorporation into the extracellular matrix. Matrix biology : journal of the International Society for Matrix Biology 17 35452817
2025 LTA4H improves the tumor microenvironment and prevents HCC progression via targeting the HNRNPA1/LTBP1/TGF-β axis. Cell reports. Medicine 16 40056904
2022 Circ-LTBP1 is involved in doxorubicin-induced intracellular toxicity in cardiomyocytes via miR-107/ADCY1 signal. Molecular and cellular biochemistry 16 35076816
1994 Assignment of the gene encoding the latent TGF-beta 1-binding protein (LTBP1) to human chromosome 2, region p12-->q22. Cytogenetics and cell genetics 15 8287682
2021 Suppression of latent transforming growth factor-β (TGF-β)-binding protein 1 (LTBP1) inhibits natural killer/ T cell lymphoma progression by inactivating the TGF-β/Smad and p38MAPK pathways. Experimental cell research 14 34418460
2005 Parathyroid hormone stimulation and PKA signaling of latent transforming growth factor-beta binding protein-1 (LTBP-1) mRNA expression in osteoblastic cells. Journal of cellular biochemistry 13 15880704
2012 Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking. PloS one 12 22295116
2003 The murine latent transforming growth factor-beta binding protein (Ltbp-1) is alternatively spliced, and maps to a region syntenic to human chromosome 2p21-22. Gene 11 12711389
2003 Expression of latent TGF-beta binding protein LTBP-1 is hormonally regulated in normal and transformed human lung fibroblasts. Growth factors (Chur, Switzerland) 11 14626352
2014 NMR spectroscopic and bioinformatic analyses of the LTBP1 C-terminus reveal a highly dynamic domain organisation. PloS one 9 24489852
2024 Targeted Mass Spectrometry of Longitudinal Patient Sera Reveals LTBP1 as a Potential Surveillance Biomarker for High-Grade Serous Ovarian Carcinoma. Journal of proteome research 8 38266179
2024 Ischemic-Preconditioning Induced Serum Exosomal miR-133a-3p Improved Post-Myocardial Infarction Repair via Targeting LTBP1 and PPP2CA. International journal of nanomedicine 6 39253060
2023 Efficient Treatment of Pulpitis via Transplantation of Human Pluripotent Stem Cell-Derived Pericytes Partially through LTBP1-Mediated T Cell Suppression. Biomedicines 6 38137420
2015 Latent transforming growth factor-β binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization. Oral diseases 6 25858550
2003 PDGF-BB induces expression of LTBP-1 but not TGF-beta1 in a rat cirrhotic fat storing cell line. Growth factors (Chur, Switzerland) 6 14708940
2019 Evaluation of the LTBP1 and Smad6 Genes Expression in Lung Tissue of Sulfur Mustard-exposed Individuals with Long-term Pulmonary Complications. Iranian journal of allergy, asthma, and immunology 5 32245290
2002 Molecular cloning and expression study of Xenopus latent TGF-beta binding protein-1 (LTBP-1). Gene 5 12062801
2018 Response to crizotinib in a non-small-cell lung cancer patient harboring an EML4-ALK fusion with an atypical LTBP1 insertion. OncoTargets and therapy 4 29535536
2021 Identification of triple gene fusion ALK-LRRN2, LTBP1-ALK, and HIP1-ALK in advanced lung adenocarcinoma and response to alectinib: A case report. Medicine 3 34941039
2013 Backbone ¹H, ¹³C and ¹⁵N resonance assignment of the C-terminal EGF-cbEGF pair of LTBP1 and flanking residues. Biomolecular NMR assignments 3 23494870
2025 CREM-activated LTBP1 transcription promotes radioresistance and immune escape in triple-negative breast cancer. Biochemical pharmacology 1 40675224
2026 Aflatoxin B1 accelerates diabetic nephropathy progression via ITGA11/LTBP1-dependent oxidative and fibrotic pathways: Evidence from multi-omics and molecular simulations. Chemico-biological interactions 0 41722833
2026 Latent transforming growth factor beta binding protein 1 (LTBP1): roles as a multifunctional extracellular matrix regulator in human disease - from molecular mechanisms to clinical translation prospects. Folia histochemica et cytobiologica 0 41811083
2026 Suppression of LTBP1 enhances the sensitivity of bladder cancer to cisplatin. Scientific reports 0 41820429
2026 Screening and Validation of LTBP1 as a Key Target of Oxymatrine in Inhibiting Cardiac Fibroblast Differentiation Under High Glucose Conditions: In Vitro and Bioinformatic Studies. International journal of molecular sciences 0 42074126
2026 MCCC2 stabilizes LTBP1 via suppressing SMURF1-dependent ubiquitination to drive bone metastasis in prostate cancer. Oncogene 0 42251191
2025 PDPN+LTBP1+ cancer-associated fibroblasts induce a liver pre-metastatic niche in gastric cancer via PDPN/YAP/LTBP1 and CCL11/CCR3 axis. Cell communication and signaling : CCS 0 41029689
2025 LTBP1 inhibits severe pneumonia caused by Staphylococcus aureus following cytomegalovirus reactivation via regulation of TGF-β1/Smad signaling pathway. Journal of infection in developing countries 0 41187191
2025 The cuproptosis-related gene ITGB6 and LTBP1 may be associated with diabetic kidney disease progression and immune cell infiltration. PeerJ 0 41244197
2025 Latent-Transforming growth factor - β Binding protein 1 (LTBP1) in corneal stroma. Matrix biology plus 0 41321407

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