Affinage

LIPG

Endothelial lipase · UniProt Q9Y5X9

Length
500 aa
Mass
56.8 kDa
Annotated
2026-04-28
92 papers in source corpus 9 papers cited in narrative 10 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LIPG (endothelial lipase) is a cell-surface serine phospholipase with predominant phospholipase A1 activity toward phosphatidylcholine in HDL that functions as a major determinant of plasma HDL cholesterol levels and, in cancer contexts, as a critical importer of extracellular lipid precursors that fuel intracellular lipid synthesis and cell proliferation. Genetic studies in mice and humans established LIPG as the quantitative trait locus gene controlling HDL-C, with regulatory variants in the LIPG promoter and 5' UTR modulating gene expression and circulating endothelial lipase levels (PMID:19436067, PMID:22174694). In triple-negative breast cancer, LIPG's catalytic phospholipase activity is required for tumor cell proliferation and cancer stem cell self-renewal, while a lipase-independent function promotes invasiveness and stemness; LIPG protein stability is maintained by the E3 ubiquitin ligase DTX3L, and oxidative stress induces LIPG via AMPK to drive protective lipid droplet accumulation (PMID:29350614, PMID:32488004, PMID:30653260). LIPG expression is transcriptionally controlled by FoxA1/FoxA2 in breast cancer and post-transcriptionally regulated through NCBP2-mediated m7G-cap binding that stabilizes LIPG mRNA and ZDHHC1/IGF2BP1-dependent m6A-mediated mRNA destabilization, with LIPG-driven lipid remodeling also supporting leukemia cell survival in hepatic microenvironments (PMID:27045898, PMID:41872454, PMID:39069526, PMID:33028621).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2009 Medium

    The identity of the gene underlying the HDL-C QTL on distal mouse chromosome 18 was unknown; quantitative complementation testing established Lipg as the causal gene controlling plasma HDL cholesterol levels, linking LIPG enzymatic function to systemic lipoprotein metabolism.

    Evidence QTL mapping, haplotype analysis, and quantitative complementation in mouse crosses

    PMID:19436067

    Open questions at the time
    • Single genetic approach in mouse; human causal variants not functionally validated at this stage
    • Mechanism by which LIPG enzymatic activity modulates HDL-C not dissected
  2. 2011 Medium

    How common genetic variation at LIPG affects HDL-C was unclear; functional reporter assays showed that a noncoding 5' UTR variant (rs34474737) reduces LIPG promoter activity and is in LD with the coding SNP rs2000813, explaining the association between this locus and elevated HDL-C via reduced endothelial lipase expression.

    Evidence Luciferase reporter assays, resequencing, LD analysis, and plasma EL protein quantification in human cohorts

    PMID:22174694

    Open questions at the time
    • Reporter assays in cell lines may not fully recapitulate in vivo regulatory context
    • Effect of rare coding variants on enzyme activity not tested
  3. 2016 High

    Whether LIPG had functions beyond lipoprotein metabolism was unknown; identification of FoxA1/2-driven LIPG transcription in breast cancer cells revealed that LIPG imports extracellular lipid precursors to support de novo intracellular lipid synthesis and tumor proliferation.

    Evidence siRNA knockdown, ChIP/reporter assays, lipid metabolomics, and proliferation assays in breast cancer cells

    PMID:27045898

    Open questions at the time
    • Specific lipid species imported by LIPG not fully resolved
    • Whether FoxA control of LIPG operates in non-breast cancer contexts untested
  4. 2018 High

    How LIPG protein levels are maintained in cancer and whether all LIPG tumor-promoting functions require catalytic activity were open questions; DTX3L was shown to stabilize LIPG protein by preventing proteasomal degradation, and separation-of-function experiments demonstrated a lipase-independent role for LIPG in invasiveness and stemness via the DTX3L–ISG15 (ISGylation) axis.

    Evidence Reciprocal co-immunoprecipitation, proteasome inhibitor assays, lipase-dead mutant rescue, and in vivo tumorigenicity in TNBC models

    PMID:29350614

    Open questions at the time
    • Structural basis of the LIPG–DTX3L interaction undefined
    • Whether ISGylation directly modifies LIPG or acts through intermediaries not resolved
  5. 2019 Medium

    The connection between metabolic stress and LIPG-dependent lipid storage was unexplored; AMPK activation under severe oxidative stress was shown to upregulate LIPG, driving lipid droplet accumulation that protects breast cancer cells from oxidative death.

    Evidence AMPK activator/inhibitor treatments, LIPG knockdown, lipid droplet staining, and cell viability assays in breast cancer cells

    PMID:30653260

    Open questions at the time
    • Single-lab study; AMPK–LIPG transcriptional link not mapped to a specific promoter element
    • Whether lipid droplet-mediated protection is specific to breast cancer or generalizable unknown
  6. 2020 High

    Whether LIPG's catalytic activity was strictly required for its tumor-promoting functions and whether pharmacological inhibition could target it were unanswered; XEN445, a selective phospholipase inhibitor, suppressed LIPG-expressing TNBC cell growth and tumor sphere formation in vitro and tumor formation in vivo, confirming phospholipase A1 activity as essential for proliferation. Separately, LIPG expression induced by the hepatic microenvironment promoted leukemia cell proliferation via PUFA-mediated pathways.

    Evidence Cell-based LIPG enzymatic assays, XEN445 pharmacological inhibition with IC50, in vivo tumor formation (TNBC); co-culture with liver stroma, lipidomics, and in vivo leukemia models (leukemia)

    PMID:32488004 PMID:33028621

    Open questions at the time
    • XEN445 selectivity in vivo not fully characterized
    • Identity of PUFA species driving leukemia survival not pinpointed
    • Whether LIPG inhibition spares normal hematopoietic cells unclear
  7. 2024 Medium

    Post-transcriptional regulation of LIPG mRNA was poorly understood; ZDHHC1 was shown to palmitoylate IGF2BP1 at Cys337, causing IGF2BP1 to destabilize LIPG mRNA via m6A modification, thereby suppressing LIPG expression and inhibiting colorectal cancer proliferation.

    Evidence S-palmitoylation assay, site-directed mutagenesis of IGF2BP1-C337, m6A modification and mRNA stability assays, KD/OE in CRC cells in vitro and in vivo

    PMID:39069526

    Open questions at the time
    • Single-lab study; palmitoylation–m6A link not confirmed by independent group
    • Specific m6A reader/writer machinery acting on LIPG mRNA not fully delineated
  8. 2026 Medium

    A second, independent post-transcriptional mechanism controlling LIPG was identified: NCBP2 directly binds the m7G cap of LIPG mRNA, stabilizing it and increasing LIPG protein expression, which drives lipid droplet accumulation and CRC tumor growth.

    Evidence RNA immunoprecipitation showing direct NCBP2–LIPG mRNA binding, mRNA stability assays, KD/OE with in vivo tumor models, lipid droplet quantification in CRC cells

    PMID:41872454

    Open questions at the time
    • Relationship between NCBP2 cap-binding and the IGF2BP1/m6A decay pathway for LIPG mRNA not integrated
    • Whether NCBP2 regulation of LIPG is CRC-specific or general unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of LIPG's dual catalytic and non-catalytic functions, the integration of multiple post-transcriptional regulatory layers (m6A decay vs. m7G cap stabilization) in physiological contexts, and whether LIPG-dependent transendothelial lipoprotein transport contributes to its tumor-promoting roles.
  • No crystal structure of full-length LIPG available
  • Transendothelial lipoprotein transport function (preprint) not yet peer-reviewed or tested in cancer models
  • In vivo therapeutic window for LIPG inhibition in cancer vs. HDL metabolism not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016787 hydrolase activity 3 GO:0008289 lipid binding 2
Localization
GO:0005811 lipid droplet 2 GO:0005886 plasma membrane 2
Pathway
R-HSA-1430728 Metabolism 4 R-HSA-1643685 Disease 4
Partners
DTX3LFOXA1FOXA2IGF2BP1NCBP2SCARB1

Evidence

Reading pass · 10 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 LIPG (endothelial lipase) is transcriptionally controlled by FoxA1 or FoxA2 in breast cancer cells, and LIPG expression enables the import of extracellular lipid precursors that support intracellular lipid synthesis and breast cancer cell proliferation; knockdown of either LIPG or FoxA reduces proliferation and impairs intracellular lipid synthesis. siRNA knockdown, lipid metabolomics, proliferation assays, ChIP/reporter assays Nature Communications High 27045898
2018 LIPG possesses a lipase-dependent function supporting cancer cell proliferation and a lipase-independent function promoting invasiveness and stemness in triple-negative breast cancer (TNBC). Mechanistically, DTX3L (an E3-ubiquitin ligase) stabilizes LIPG protein by inhibiting proteasome-mediated degradation, and LIPG participates in DTX3L-ISG15 signaling (ISGylation pathway) to drive TNBC malignancy. siRNA/shRNA knockdown, proteasome inhibitor assays, co-immunoprecipitation, lipase-dead mutant rescue experiments, in vivo tumorigenicity assays eLife High 29350614
2019 Severe oxidative stress activates AMPK, which triggers LIPG upregulation in breast cancer cells, leading to intracellular lipid droplet accumulation that protects cells from oxidative stress-induced death; neutralizing oxidative stress abrogates both LIPG upregulation and the concomitant lipid storage. AMPK activation/inhibition, LIPG knockdown, lipid droplet staining, cell viability assays International Journal of Cancer Medium 30653260
2020 LIPG expression is induced by the hepatic microenvironment in leukemia cells, stimulating tumor cell proliferation through polyunsaturated fatty acid (PUFA)-mediated pathways and promoting survival by stabilizing antiapoptotic proteins. Co-culture with liver stromal cells, LIPG knockdown/overexpression, lipidomics, apoptosis assays, in vivo leukemia models Cancer Discovery Medium 33028621
2020 LIPG functions as a cell-surface phospholipase A1 active toward phosphatidylcholine in HDL; its phospholipase catalytic activity is required for LIPG-mediated support of TNBC cell proliferation and tumor formation, as demonstrated by the specific phospholipase inhibitor XEN445 selectively suppressing LIPG-expressing TNBC cell growth and cancer stem cell self-renewal in vitro and tumor formation in vivo. Cell-based LIPG enzymatic assay, XEN445 pharmacological inhibition, IC50 determination, proliferation assays, tumor sphere assays, in vivo tumor formation Scientific Reports High 32488004
2024 ZDHHC1 palmitoylates IGF2BP1 at Cys337, causing IGF2BP1 to destabilize LIPG mRNA via m6A modification, thereby downregulating LIPG expression and inhibiting colorectal cancer cell proliferation and invasion. S-palmitoylation assay, site-directed mutagenesis (IGF2BP1-C337), m6A modification assay, LIPG mRNA stability assay, KD/OE in vitro and in vivo Cancer Gene Therapy Medium 39069526
2009 Quantitative complementation testing and haplotype analysis in mouse crosses identified Lipg as the QTL gene controlling plasma HDL cholesterol levels on distal chromosome 18. QTL analysis, haplotype analysis, quantitative complementation testing, expression analysis, sequencing Journal of Lipid Research Medium 19436067
2011 Rare regulatory variants in the LIPG promoter and 5' UTR alter LIPG gene expression (measured by luciferase reporter assay), and a common noncoding variant (rs34474737) in the 5' UTR that decreases LIPG promoter activity is in linkage disequilibrium with the coding SNP rs2000813, explaining the association of rs2000813 with reduced plasma endothelial lipase levels and increased HDL-C. Luciferase reporter assays, resequencing, LD analysis, plasma EL protein quantification PLoS Genetics Medium 22174694
2025 Endothelial lipase (EL/LIPG) promotes binding, uptake, and transcytosis of both LDL and HDL across primary human aortic endothelial cells, with its catalytic activity being essential for lipoprotein transport (but not surface association); ANGPTL3 selectively inhibits EL-mediated transendothelial LDL transport but not HDL transport; EL and scavenger receptor BI (SR-BI) act sequentially to mediate LDL uptake but independently for HDL uptake. Lipoprotein transcytosis assays in primary HAEC, catalytic mutant EL, ANGPTL3 inhibition, SR-BI co-functional studies, ex vivo bovine aorta LDL accumulation bioRxivpreprint Medium
2026 NCBP2 stabilizes LIPG mRNA by directly binding the m7G motif in the 5'-cap structure of LIPG mRNA, increasing LIPG expression and promoting LIPG-dependent lipid droplet accumulation in colorectal cancer cells, which drives CRC proliferation, migration, and tumor invasion. RNA immunoprecipitation (RIP), LIPG mRNA stability assay, KD/OE in vitro and in vivo, lipid droplet quantification Communications Biology Medium 41872454

Source papers

Stage 0 corpus · 92 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1995 Molecular analysis of the plasmid-encoded hemolysin of Escherichia coli O157:H7 strain EDL 933. Infection and immunity 536 7868227
2006 Contractile properties of EDL and soleus muscles of myostatin-deficient mice. Journal of applied physiology (Bethesda, Md. : 1985) 126 16709649
1998 Differential myogenicity of satellite cells isolated from extensor digitorum longus (EDL) and soleus rat muscles revealed in vitro. Cell and tissue research 88 9477302
2005 Soleus and EDL muscle contractility across the lifespan of female C57BL/6 mice. Experimental gerontology 78 16243468
2003 KATP channels depress force by reducing action potential amplitude in mouse EDL and soleus muscle. American journal of physiology. Cell physiology 67 12917105
2001 Persistence of botulinum neurotoxin A demonstrated by sequential administration of serotypes A and E in rat EDL muscle. Toxicon : official journal of the International Society on Toxinology 64 10978741
2010 Diabetes induces compositional, structural and functional alterations on rat skeletal soleus muscle revealed by FTIR spectroscopy: a comparative study with EDL muscle. The Analyst 59 20967384
2004 Association between single-nucleotide polymorphisms in the endothelial lipase (LIPG) gene and high-density lipoprotein cholesterol levels. Biochimica et biophysica acta 59 14984737
2008 A gene for speed: contractile properties of isolated whole EDL muscle from an alpha-actinin-3 knockout mouse. American journal of physiology. Cell physiology 57 18650267
2016 FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth. Nature communications 55 27045898
2017 Mouse soleus (slow) muscle shows greater intramyocellular lipid droplet accumulation than EDL (fast) muscle: fiber type-specific analysis. Journal of muscle research and cell motility 51 28281032
2016 The effect of obesity on the contractile performance of isolated mouse soleus, EDL, and diaphragm muscles. Journal of applied physiology (Bethesda, Md. : 1985) 49 27856719
2019 LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer. International journal of cancer 46 30653260
2005 Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans. Atherosclerosis 46 16023652
2018 LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer. eLife 43 29350614
2010 Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT. Atherosclerosis 34 20466371
2010 Grip force, EDL contractile properties, and voluntary wheel running after postdevelopmental myostatin depletion in mice. Journal of applied physiology (Bethesda, Md. : 1985) 33 20595537
2020 Comparative analysis of the transcriptomes of EDL, psoas, and soleus muscles from mice. BMC genomics 32 33213377
2016 Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms. Molecular psychiatry 32 27431295
2003 Ca2+ uptake and cellular integrity in rat EDL muscle exposed to electrostimulation, electroporation, or A23187. American journal of physiology. Regulatory, integrative and comparative physiology 32 12623773
2018 Single EDL Myofiber Isolation for Analyses of Quiescent and Activated Muscle Stem Cells. Methods in molecular biology (Clifton, N.J.) 31 29030819
2011 Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol. PLoS genetics 31 22174694
2012 Comparative analysis of semaphorin 3A in soleus and EDL muscle satellite cells in vitro toward understanding its role in modulating myogenin expression. The international journal of biochemistry & cell biology 28 23085379
2009 Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene. Journal of lipid research 27 19436067
2005 Ionic mechanisms of excitation-induced regulation of Na+-K+-ATPase mRNA expression in isolated rat EDL muscle. American journal of physiology. Regulatory, integrative and comparative physiology 26 16357096
2003 EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed. Development (Cambridge, England) 26 12874129
1986 Fast to slow transition induced by experimental myotonia in rat EDL muscle. Pflugers Archiv : European journal of physiology 26 2938075
2020 The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG. Cancer discovery 25 33028621
2018 LipG a bifunctional phospholipase/thioesterase involved in mycobacterial envelope remodeling. Bioscience reports 24 30487163
2000 Differential effects of NT-3 on reinnervation of the fast extensor digitorum longus (EDL) and the slow soleus muscle of rat. The European journal of neuroscience 24 10762316
2006 Molecular impact of clenbuterol and isometric strength training on rat EDL muscles. Pflugers Archiv : European journal of physiology 23 17093970
2002 Temperature dependency of force loss and Ca(2+) homeostasis in mouse EDL muscle after eccentric contractions. American journal of physiology. Regulatory, integrative and comparative physiology 22 11893617
1991 Sodium current and membrane potential in EDL muscle fibers from normal and dystrophic (mdx) mice. The American journal of physiology 21 1928332
2006 Targeted functional imaging of estrogen receptors with 99mTc-GAP-EDL. European journal of nuclear medicine and molecular imaging 19 17021817
2001 Acute exposure to AICAR increases glucose transport in mouse EDL and soleus muscle. Biochemical and biophysical research communications 19 11352652
2024 ZDHHC1 downregulates LIPG and inhibits colorectal cancer growth via IGF2BP1 Palmitoylation. Cancer gene therapy 18 39069526
2000 Differential expression of FGF receptors and of myogenic regulatory factors in primary cultures of satellite cells originating from fast (EDL) and slow (Soleus) twitch rat muscles. Cellular and molecular biology (Noisy-le-Grand, France) 18 11075953
1998 Expression of sarcoplasmic/endoplasmic reticulum Ca2+ ATPases in the rat extensor digitorum longus (EDL) muscle regenerating from notexin-induced necrosis. Journal of muscle research and cell motility 18 9836148
2010 Association of the LIPG 584C > T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids in health and disease 17 20923576
2020 Inhibition of LIPG phospholipase activity suppresses tumor formation of human basal-like triple-negative breast cancer. Scientific reports 15 32488004
2020 LIPG: an inflammation and cancer modulator. Cancer gene therapy 15 32572177
2010 Photodegradation of crystal violet in TiO(2) suspensions using UV-vis irradiation from two microwave-powered electrodeless discharge lamps (EDL(-2)): products, mechanism and feasibility. Journal of hazardous materials 15 21095059
2012 Resequencing CETP, LIPC and LIPG genes in Thai subjects with hyperalphalipoproteinemia. The American journal of cardiology 13 22464213
2011 Interactions of the LIPG 584C>T polymorphism and alcohol consumption on serum lipid levels. Alcohol (Fayetteville, N.Y.) 12 21816559
2001 Denervation enhances the physiological effects of the K(ATP) channel during fatigue in EDL and soleus muscle. American journal of physiology. Regulatory, integrative and comparative physiology 11 11404279
2021 Abundant Synthesis of Netrin-1 in Satellite Cell-Derived Myoblasts Isolated from EDL Rather Than Soleus Muscle Regulates Fast-Type Myotube Formation. International journal of molecular sciences 9 33925862
2017 Hypertrophy Stimulation at the Onset of Type I Diabetes Maintains the Soleus but Not the EDL Muscle Mass in Wistar Rats. Frontiers in physiology 9 29123487
2014 EDL-360: A Potential Novel Antiglioma Agent. Journal of cancer science & therapy 9 25574358
2007 Plasma and cerebrospinal fluid pharmacokinetics of the novel tetrahydroisoquinoline EDL-155 in rats. Cancer chemotherapy and pharmacology 9 17768626
2005 Controlled intermittent shortening contractions of a muscle-tendon complex: muscle fibre damage and effects on force transmission from a single head of rat EDL. Journal of muscle research and cell motility 9 16322914
2020 Complementary behaviour of EDL and HER activity in functionalized graphene nanoplatelets. Nanoscale 8 31895391
2016 Higher insulin sensitivity in EDL muscle of rats fed a low-protein, high-carbohydrate diet inhibits the caspase-3 and ubiquitin-proteasome proteolytic systems but does not increase protein synthesis. The Journal of nutritional biochemistry 8 27239756
2020 Atherosclerotic cardiovascular disease in hyperalphalipoproteinemia due to LIPG variants. Journal of clinical lipidology 7 33414088
2012 Population-Based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels. Frontiers in genetics 7 22723803
2008 Giant cell tumor of the EDL tendon sheath: an unusual cause of hallux valgus. Foot & ankle international 7 18510911
2007 Functional imaging of estrogen receptors with radiolabeled-GAP-EDL in rabbit endometriosis model. Academic radiology 7 17707312
2019 Association between the LIPG polymorphisms and serum lipid levels in the Maonan and Han populations. The journal of gene medicine 6 30657227
2017 Fine Mapping of a Degenerated Abdominal Legs Mutant (Edl) in Silkworm, Bombyx mori. PloS one 6 28081147
2017 Effects of beta-hydroxy-beta-methylbutyrate (HMB) on the expression of ubiquitin ligases, protein synthesis pathways and contractile function in extensor digitorum longus (EDL) of fed and fasting rats. The journal of physiological sciences : JPS 6 28083734
2021 JNK activation in TA and EDL muscle is load-dependent in rats receiving identical excitation patterns. Scientific reports 5 34385505
2019 LIPG SNPs, their haplotypes and gene-environment interactions on serum lipid levels. Lipids in health and disease 5 30621702
2013 The effects of endothelial lipase gene (LIPG) variants on inflammation marker levels and atherosclerosis development. Molecular biology reports 5 23673478
2009 Fast and sensitive liquid chromatography/electrospray mass spectrometry method to study ocular penetration of EDL-155, a novel antitumor agent for retinoblastoma in rats. Journal of mass spectrometry : JMS 5 19160451
1995 Creatine kinase release from isolated EDL muscles in chronic ethanol-treated rats. Alcohol (Fayetteville, N.Y.) 5 7772266
2023 Integrated analysis of DNA methylome and transcriptome reveals SFRP1 and LIPG as potential drivers of ovarian cancer metastasis. Journal of gynecologic oncology 4 37417299
2022 The effect of muscle length on post-tetanic potentiation of C57BL/6 and skMLCK-/- mouse EDL muscles. Journal of muscle research and cell motility 4 35771335
2012 EDL-291, a novel isoquinoline, presents antiglioblastoma effects in vitro and in vivo. Anti-cancer drugs 4 22391460
2001 Diversity of myosin heavy chain expression in satellite cells from mouse soleus and EDL muscles. Folia histochemica et cytobiologica 4 11766762
1994 Effects of orchiectomy on EDL muscle ultrastructure and energy-supplying enzymes in growing male guinea pigs. The American journal of physiology 4 7508185
2021 Angiotensin 1-7 prevents the excessive force loss resulting from 14- and 28-day denervation in mouse EDL and soleus muscle. The Journal of general physiology 3 34739541
2020 Chronic Undernutrition Differentially Changes Muscle Fiber Types Organization and Distribution in the EDL Muscle Fascicles. Frontiers in physiology 3 32848813
2019 Molecular characterization and immunogenic function of ML1899 (LipG) of Mycobacterium leprae. Journal of medical microbiology 3 31553301
2016 Association of the CETP Taq1B and LIPG Thr111Ile Polymorphisms with Glycated Hemoglobin and Blood Lipids in Newly Diagnosed Hyperlipidemic Patients. Canadian journal of diabetes 3 27590083
2001 Partial ischemia reduces the efficiency of sarcoplasmic reticulum Ca2+ transport in rat EDL. Molecular and cellular biochemistry 3 11693204
2025 Differential regulation of MMP activity by TGFβ1 in fast- and slow- twitch muscle repair: insights from EDL and soleus muscle-derived myoblasts. Frontiers in cell and developmental biology 2 40535569
2023 Glutamine supplementation accelerates functional recovery of EDL muscles after injury by modulating the expression of S100 calcium-binding proteins. Histochemistry and cell biology 2 37179509
2022 Loss of α-actinin-3 confers protection from eccentric contraction damage in fast-twitch EDL muscles from aged mdx dystrophic mice by reducing pathological fibre branching. Human molecular genetics 2 34761268
2021 LIPG endothelial lipase and breast cancer risk by subtypes. Scientific reports 2 34001944
2011 [Oxidative stress in soleus and extensor digitorum longus (EDL) muscles of spontaneously hypertensive rats]. Investigacion clinica 2 21950195
2025 LIPG-mediated regulation of lipid deposition and proliferation in goat intramuscular preadipocytes involves the PPARα signaling pathway. PloS one 1 39946436
2025 IDP-EDL: enhancing intrinsically disordered protein prediction by combining protein language model and ensemble deep learning. Briefings in bioinformatics 1 40254833
2024 Sucrose-induced metabolic syndrome differentially affects energy metabolism and fiber phenotype of EDL and soleus muscles during exercise in the rat. Physiological reports 1 39001594
2022 Short communication: Leucine, but not muscle contractions, stimulates protein synthesis in isolated EDL muscles from golden geckos. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 1 35351650
2011 Solving EDL configuration near a dissimilarly charged protrusions surface model using perturbation method. Colloids and surfaces. B, Biointerfaces 1 21565471
2001 Sequencing and chromosomal assignment of the rat endothelial-derived lipase gene (Lipg). DNA sequence : the journal of DNA sequencing and mapping 1 11924532
1990 Regenerated EDL muscle of rats requires innervation to maintain AChE molecular forms. Muscle & nerve 1 2385257
2026 NCBP2 drives colorectal cancer growth and metastasis through LIPG-mediated lipid droplet accumulation. Communications biology 0 41872454
2023 Exploration of Charge Storage Behavior of Binder-Free EDL Capacitors in Aqueous Electrolytes. ACS omega 0 36687114
2021 Case-Control Study and Meta-Analysis of the Association Between LIPG rs9958947 SNP and Stroke Risk. Journal of molecular neuroscience : MN 0 33479916
2011 Possible mechanisms for the effect of protein sensitization on functional properties of the isolated m. soleus and m. EDL from mice. Bulletin of experimental biology and medicine 0 21240338
2011 EDL configuration on a dissimilarly charged protrusion array via double Fourier series and perturbation method. Colloids and surfaces. B, Biointerfaces 0 21778040
2007 Isoproterenol hydrochloride augments collagen proliferation and ATPase activity in mice soleus and EDL muscles. Acta physiologica Hungarica 0 17853774