Affinage

LIPC

Hepatic triacylglycerol lipase · UniProt P11150

Round 2 corrected
Length
499 aa
Mass
55.9 kDa
Annotated
2026-04-28
130 papers in source corpus 13 papers cited in narrative 13 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LIPC encodes hepatic lipase (HL), a liver-expressed serine lipase that hydrolyzes triglycerides and phospholipids in circulating lipoproteins (TG:PL activity ratio ~24:1) without requiring apolipoprotein C-II as a cofactor, and is a major determinant of plasma HDL-C levels (PMID:12032167, PMID:9114024). Its transcription is driven by HNF4α acting on DR1 and DR4 promoter elements, co-activated by PGC-1α, repressed by ARP-1, and further activated by HNF1α, while post-transcriptional regulation by miR-27b downregulates LIPC and its upstream activators HNF4α, PPARα, and Jun (PMID:16603721, PMID:35483451). Common promoter variants (notably −514C>T) reduce HL activity and raise HDL-C additively with BMI effects and independently of androgen signaling, while the rare gain-of-function E97G variant selectively hyperactivates phospholipase A1 activity through a substrate-access motif, causing combined hypocholesterolemia (PMID:9469601, PMID:35899625). Beyond extracellular lipoprotein remodeling, HL-mediated intracellular triglyceride degradation in hepatocytes impedes hepatitis C virus replication, and HL released into plasma enhances anti-Factor Xa anticoagulant activity (PMID:35483451, PMID:2433786).

Mechanistic history

Synthesis pass · year-by-year structured walk · 6 steps
  1. 1986 Medium

    Establishing that hepatic lipase has functions beyond lipid hydrolysis, purified HL was shown to enhance anti-Factor Xa activity and inhibit thrombin generation in plasma, revealing a direct anticoagulant role.

    Evidence Purified HTGL added to human plasma with in vitro anti-Xa and thrombin generation assays, plus in vivo release by pentosan polysulphate in volunteers

    PMID:2433786

    Open questions at the time
    • Anticoagulant mechanism not structurally resolved
    • No in vivo demonstration of physiological relevance of HL anticoagulant activity
    • Interaction partners in the coagulation cascade not identified
  2. 1997 High

    Linkage and association studies established LIPC as a major genetic determinant of plasma HDL-C, with promoter polymorphisms accounting for ~25% of interindividual HDL-C variation and the −514T allele linked to reduced HL activity and elevated HDL-C across ethnic groups.

    Evidence Family-based linkage analysis, LIPC 5′ flanking sequencing, replicated population association studies, and post-heparin HL activity assays in white and African American cohorts

    PMID:9114024 PMID:9469601

    Open questions at the time
    • Promoter variant effect on transcription factor binding not yet resolved at this time
    • Causal chain from reduced HL activity to HDL-C elevation not fully delineated
  3. 1998 Medium

    Pharmacological and anthropometric studies demonstrated that the −514C>T effect on HL activity is independent of androgen signaling and additive with BMI, clarifying that LIPC genotype and metabolic state regulate HL through separable pathways.

    Evidence Stanozolol challenge with post-heparin HL activity in men and women; multivariate analysis of BMI and genotype effects on HL activity

    PMID:9610782 PMID:9684756

    Open questions at the time
    • Molecular mechanism by which BMI increases HL activity unknown
    • Sex-hormone receptor interaction with the LIPC promoter not tested directly
  4. 2002 High

    Biochemical characterization placed HL's enzymatic specificity between LPL and endothelial lipase, defining its TG:PL ratio (~24:1), apoC-II independence, and salt resistance, establishing its unique niche in lipoprotein remodeling.

    Evidence Radiolabeled substrate assays with recombinant HL, LPL, and EL; apoC-II dependence and NaCl inhibition tests

    PMID:12032167

    Open questions at the time
    • No crystal structure available to explain substrate selectivity at atomic resolution
    • In vivo substrate preferences on native lipoproteins not quantified
  5. 2006 High

    The transcriptional regulation of LIPC was resolved: HNF4α drives transcription via DR1/DR4 elements with PGC-1α co-activation, ARP-1 displaces HNF4α for repression, and HNF1α provides additive activation — confirmed by Hnf4α liver-specific knockout abolishing HL expression.

    Evidence Promoter-reporter assays, EMSA, Medica 16 HNF4α antagonist treatment, Hnf4α liver-specific knockout mice

    PMID:16603721

    Open questions at the time
    • Chromatin-level regulation (histone modifications, enhancer contacts) not addressed
    • How the −514C>T variant intersects with HNF4α/DR1 binding not directly tested
  6. 2022 High

    Two studies expanded LIPC biology: miR-27b was identified as a post-transcriptional suppressor of LIPC (also targeting its activators HNF4α, PPARα, Jun), and intracellular HL-mediated triglyceride degradation was shown to impede HCV replication; separately, the E97G gain-of-function variant was shown to selectively hyperactivate phospholipase A1 activity via a substrate-access motif, causing combined hypocholesterolemia in humans and mice.

    Evidence Activity-based serine hydrolase proteomics, miRNA mimics/inhibitors, LIPC knockdown/overexpression with HCV infection assays; protein homology modeling, in vitro lipase/phospholipase assays, human carrier lipidomics, APOE*3.Leiden.CETP mouse overexpression

    PMID:35483451 PMID:35899625

    Open questions at the time
    • Structural basis of E97G phospholipase selectivity not confirmed by crystal structure
    • Whether miR-27b regulation of LIPC is relevant in non-HCV hepatic contexts is untested
    • Intracellular HL trafficking and compartmentalization poorly defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • No high-resolution structure of hepatic lipase exists; the structural basis for differential TG vs. phospholipase substrate selectivity, the mechanism by which intracellular HL accesses lipid droplet triglycerides, and the physiological significance of HL's anticoagulant activity remain unresolved.
  • No crystal or cryo-EM structure
  • Intracellular lipid droplet access mechanism unknown
  • In vivo relevance of HL anticoagulant function not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016787 hydrolase activity 3 GO:0008289 lipid binding 2
Localization
GO:0005576 extracellular region 2 GO:0005829 cytosol 1
Pathway
R-HSA-1430728 Metabolism 4 R-HSA-109582 Hemostasis 1
Partners
HNF1AHNF4ANR2F2PPARGC1A

Evidence

Reading pass · 13 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 The LIPC gene promoter is directly regulated by hepatocyte nuclear factor 4α (HNF4α) via two newly identified direct repeat elements (DR1 and DR4); PGC-1α co-activates HNF4α-dependent LIPC transcription; ARP-1 displaces HNF4α from DR1 and represses transcription; HNF1α activates LIPC through its own binding site and additively with HNF4α. Disruption of Hnf4α in mice abolishes hepatic HL mRNA expression, confirming in vivo relevance. Promoter-reporter luciferase assays, electrophoretic mobility shift assays, HNF4α antagonist (Medica 16) treatment of cells, and Hnf4α liver-specific knockout mice Journal of lipid research High 16603721
2022 A gain-of-function variant LIPC-E97G specifically increases the phospholipase A1 activity of hepatic lipase (without changing triglyceride lipase activity) by modifying an evolutionarily conserved motif that controls substrate access to the catalytic site, causing combined hypocholesterolemia (very low LDL-C and HDL-C) and increased lysophospholipid/phospholipid ratio in plasma. Mice overexpressing LIPC-E97G recapitulate the hypocholesterolemic phenotype and show increased catabolism of triglyceride-rich lipoproteins by extrahepatic tissues. Protein homology modeling, in vitro triglyceride lipase and phospholipase activity assays in cell culture, lipidomics/NMR lipoprotein profiling in human carriers, APOE*3.Leiden.CETP transgenic mouse overexpression model Circulation High 35899625
1997 Genetic variation at the LIPC locus accounts for approximately 25% of interindividual variation in plasma HDL-C levels in American white families; four novel 5′-flanking polymorphisms in complete linkage disequilibrium define a rare LIPC allele associated with elevated plasma HDL-C and apolipoprotein AI in men, with the effect more pronounced in homozygotes. Linkage analysis in nuclear families, DNA sequencing of the LIPC 5′ flanking region, population association studies replicated in an independent cohort Proceedings of the National Academy of Sciences of the United States of America High 9114024
1998 The LIPC -514T allele is associated with decreased post-heparin plasma hepatic lipase activity in both African American and white American men; this allele is approximately 3-fold more frequent in African Americans, contributing to their higher plasma HDL-C concentrations. Post-heparin plasma hepatic lipase activity assay, genotyping of the -514C>T promoter polymorphism, population comparison study Journal of lipid research Medium 9469601
1998 The LIPC -514 polymorphism does not influence the androgenic stimulation of hepatic lipase activity: homozygous -514T and -514C men showed similar increases in hepatic lipase activity in response to anabolic steroid (stanozolol) treatment, and the effect of the polymorphism on HL activity was quantitatively similar in both sexes, indicating its impact is independent of androgen signaling. Pharmacological androgen challenge (stanozolol administration), post-heparin hepatic lipase activity measurement, LIPC genotyping in men and premenopausal women Journal of lipid research Medium 9684756
1998 Body mass index (BMI) and the LIPC -514C>T polymorphism independently and additively determine post-heparin hepatic lipase activity; higher BMI leads to increased HL activity, and this effect is additive to—not synergistic with—the effect of the -514 allele. Post-heparin hepatic lipase activity assay, LIPC genotyping, multivariate analysis in white and African American men Journal of lipid research Medium 9610782
2003 Atorvastatin dose-dependently decreases hepatic lipase activity in type 2 diabetes (−11% at 10 mg, −22% at 80 mg); the magnitude of this reduction is independent of sex and the LIPC C→T promoter variant, demonstrating a statin effect on HL that is separable from genotype-driven variation. Double-blind, randomized, placebo-controlled trial with post-heparin hepatic lipase activity measurement and LIPC genotyping Diabetes care Medium 12547874
2001 Interaction between the LIPC -514C>T and APOC3 -482C>T promoter variants influences glucose tolerance: carriers of at least one rare allele of both genes showed the highest peak glucose and area-under-the-curve for glucose and insulin during oral glucose tolerance testing, as well as highest diastolic blood pressure, revealing a gene–gene interaction affecting insulin sensitivity. Oral glucose tolerance testing, post-heparin lipase activity, genotyping for LIPC and APOC3 promoter variants in 714 young healthy males (EARS-II cohort) Annals of human genetics Medium 11427182
1986 Subcutaneous pentosan polysulphate (heparin analogue) releases hepatic triglyceride lipase (HTGL/HL) into plasma; purified HTGL added to plasma markedly enhances anti-Factor Xa clotting activity and inhibits lipid peroxide-induced thrombin generation by ~70%, demonstrating a direct anticoagulant function of HL beyond its lipase activity. In vivo administration to normal volunteers, post-heparin plasma lipase activity measurement, in vitro addition of purified HTGL to plasma, anti-Xa and thrombin generation assays Thrombosis and haemostasis Medium 2433786
2002 Hepatic lipase (HL) has a triglyceride lipase to phospholipase activity ratio of 24.1, placing it between lipoprotein lipase (ratio ~140) and endothelial lipase (ratio ~0.65); HL does not require apolipoprotein C-II for activation and efficiently hydrolyzes triglyceride-rich lipoproteins (chylomicrons, VLDL, IDL); unlike LPL, HL activity is not inhibited by 1 M NaCl. Radiolabeled lipid substrate assays (triglyceride and phospholipase activities) using conditioned medium from cells expressing recombinant HL, LPL, and EL; apoC-II dependence and salt inhibition tests; isolated lipoprotein fraction hydrolysis assays Journal of lipid research High 12032167
2022 The microRNA miR-27b directly downregulates LIPC expression in hepatic cells; miR-27b also regulates the LIPC transcriptional activators HNF4α, PPARα, and Jun. LIPC knockdown increases intracellular triglyceride levels and facilitates HCV replication, while LIPC overexpression reduces intracellular triglycerides, demonstrating that LIPC-mediated triglyceride degradation impedes the HCV life cycle. Activity-based protein profiling with serine hydrolase probe, stable isotope labeling and mass spectrometry, miRNA mimic/inhibitor transfection, LIPC knockdown and overexpression, HCV infection assays, intracellular triglyceride quantification The Journal of biological chemistry High 35483451
2009 A novel heterozygous LIPC missense mutation G119S was identified in a Thai subject with hyperalphalipoproteinemia and low hepatic lipase activity; the mutation occurs in a functionally important domain, is evolutionarily conserved, and is predicted damaging, consistent with loss-of-function causing elevated HDL-C. Post-heparin hepatic lipase activity measurement, sequencing of all LIPC coding regions and exon-intron junctions, evolutionary conservation analysis, computational functional prediction Metabolism: clinical and experimental Low 19428034
2021 LIPC promoter SNPs (particularly rs10468017) are associated with plasma levels of specific phosphatidylethanolamine glycerophospholipid metabolites, supporting a role for LIPC in glycerophospholipid metabolism relevant to AMD pathogenesis. Metabolite quantitative trait loci (met-QTL) analysis combining SNP genotyping and mass spectrometry-based metabolomics in AMD patients and controls; linear regression with meta-analysis Ophthalmology science Low 34382031

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2873 20686565
2013 Discovery and refinement of loci associated with lipid levels. Nature genetics 2409 24097068
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
1999 Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nature genetics 1381 10391209
2008 Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nature genetics 1310 18193043
2014 An atlas of genetic influences on human blood metabolites. Nature genetics 1209 24816252
2008 Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nature genetics 1130 18193044
2008 Common variants at 30 loci contribute to polygenic dyslipidemia. Nature genetics 1113 19060906
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2008 Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nature genetics 695 19060911
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2013 Seven new loci associated with age-related macular degeneration. Nature genetics 649 23455636
2008 Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nature genetics 569 19060910
2008 Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS genetics 532 19043545
2008 Polymorphisms associated with cholesterol and risk of cardiovascular events. The New England journal of medicine 530 18354102
2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nature genetics 436 22286219
2010 Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America 433 20385819
2010 Genome-wide association study of hematological and biochemical traits in a Japanese population. Nature genetics 406 20139978
2010 Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proceedings of the National Academy of Sciences of the United States of America 375 20385826
2010 Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arteriosclerosis, thrombosis, and vascular biology 351 20864672
2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. PloS one 312 23251661
2001 Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Proceedings of the National Academy of Sciences of the United States of America 300 11752456
2009 Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS genetics 284 19936222
1995 Peroxynitrite-induced apoptosis in HL-60 cells. The Journal of biological chemistry 278 7622447
2012 Seventy-five genetic loci influencing the human red blood cell. Nature 266 23222517
2011 Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS genetics 258 21347282
2002 Characterization of the lipolytic activity of endothelial lipase. Journal of lipid research 228 12032167
1997 A hepatic lipase (LIPC) allele associated with high plasma concentrations of high density lipoprotein cholesterol. Proceedings of the National Academy of Sciences of the United States of America 220 9114024
2011 Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Human molecular genetics 208 21665990
2011 Toward an understanding of the protein interaction network of the human liver. Molecular systems biology 207 21988832
2011 A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes 205 21386085
1991 Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells. Biochemistry 205 2007135
2010 Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. Diabetes 196 20682687
1975 HL-A system and diabetes mellitus. Diabetes 187 48487
1998 Hepatic lipase activity is lower in African American men than in white American men: effects of 5' flanking polymorphism in the hepatic lipase gene (LIPC). Journal of lipid research 125 9469601
1999 Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. The Journal of biological chemistry 91 9933590
1984 Modulation of c-myc expression in the HL-60 cell line. Biochemical and biophysical research communications 90 6424665
1998 Actinobacillus actinomycetemcomitans leukotoxin induces apoptosis in HL-60 cells. Infection and immunity 89 9712803
1995 The three genes lipB, lipC, and lipD involved in the extracellular secretion of the Serratia marcescens lipase which lacks an N-terminal signal peptide. Journal of bacteriology 79 7592412
1993 Induction of functional lipoxin A4 receptors in HL-60 cells. Blood 77 8389617
1989 Reactivity of anti-neutrophil cytoplasmic autoantibodies with HL-60 cells. Clinical immunology and immunopathology 76 2551551
2002 Selenite and selenomethionine promote HL-60 cell cycle progression. The Journal of nutrition 74 11925459
1999 Effect of citrus flavonoids on HL-60 cell differentiation. Anticancer research 65 10368686
2002 Induction and mechanism of apoptotic cell death by propofol in HL-60 cells. Acta anaesthesiologica Scandinavica 61 12366500
1976 Genetic association of multiple sclerosis and HL-A determinants. Neurology 61 54888
2010 Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration. Molecular vision 56 21139980
2018 Resveratrol induces autophagy-dependent apoptosis in HL-60 cells. BMC cancer 55 29788929
1990 Expression of IMP dehydrogenase in differentiating HL-60 cells. Blood 55 1967537
1998 Overexpression of prothymosin alpha accelerates proliferation and retards differentiation in HL-60 cells. The Biochemical journal 54 9560301
2012 Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt. Molecular biology reports 53 22555976
1991 Expression of c-jun during macrophage differentiation of HL-60 cells. Blood 53 1904283
1986 Establishment of eosinophilic sublines from human promyelocytic leukemia (HL-60) cells: demonstration of multipotentiality and single-lineage commitment of HL-60 stem cells. Blood 52 3486011
1975 Increased frequency of HL-A8 in Sjogren's syndrome. Tissue antigens 50 1216249
1999 Absence of association between genetic variation in the LIPC gene promoter and plasma lipoproteins in three Canadian populations. Atherosclerosis 49 10487498
1991 Differentiation of HL-60 cells into cells with the osteoclast phenotype. Endocrinology 49 1649744
1982 Dexamethasone synergistically induces chemotactic peptide receptor expression in HL-60 cells. Blood 49 6277411
1998 Body mass index and hepatic lipase gene (LIPC) polymorphism jointly influence postheparin plasma hepatic lipase activity. Journal of lipid research 48 9610782
1990 Expression of transcobalamin II receptors by human leukemia K562 and HL-60 cells. Blood 48 2169922
2006 Influence of galangin on HL-60 cell proliferation and survival. Cancer letters 47 16413113
2009 Chemotaxis in neutrophil-like HL-60 cells. Methods in molecular biology (Clifton, N.J.) 44 19763966
2011 LipC (Rv0220) is an immunogenic cell surface esterase of Mycobacterium tuberculosis. Infection and immunity 43 22038913
2015 CETP/LPL/LIPC gene polymorphisms and susceptibility to age-related macular degeneration. Scientific reports 42 26503844
2010 Lipase LipC affects motility, biofilm formation and rhamnolipid production in Pseudomonas aeruginosa. FEMS microbiology letters 42 20546309
2008 Isoliquiritigenin induces monocytic differentiation of HL-60 cells. Free radical biology & medicine 40 19110051
2006 Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter. Journal of lipid research 40 16603721
2003 Atorvastatin dose-dependently decreases hepatic lipase activity in type 2 diabetes: effect of sex and the LIPC promoter variant. Diabetes care 40 12547874
2012 Association studies of several cholesterol-related genes (ABCA1, CETP and LIPC) with serum lipids and risk of Alzheimer's disease. Lipids in health and disease 39 23181436
1990 Cardiovascular effects of forskolin (HL 362) in patients with idiopathic congestive cardiomyopathy--a comparative study with dobutamine and sodium nitroprusside. Journal of cardiovascular pharmacology 39 1696672
2015 cAMP induces hypertrophy and alters DNA methylation in HL-1 cardiomyocytes. American journal of physiology. Cell physiology 38 26224577
2001 Erianin induces apoptosis in human leukemia HL-60 cells. Acta pharmacologica Sinica 38 11749794
1997 Paracetamol inhibits cell cycling and induces apoptosis in HL-60 cells. Pharmacology & toxicology 38 9444671
2011 GADD45α and annexin A1 are involved in the apoptosis of HL-60 induced by resveratrol. Phytomedicine : international journal of phytotherapy and phytopharmacology 36 21277758
1999 Translational control of specific genes during differentiation of HL-60 cells. The Journal of biological chemistry 36 10318851
2008 Aldosterone induces cardiotrophin-1 expression in HL-1 adult cardiomyocytes. Endocrinology 35 18566129
1996 Cell cycle-dependence of HL-60 cell deformability. Biophysical journal 35 8785361
1983 Control of cell differentiation during proliferation. I. Monocytic differentiation of HL-60 promyelocytes. Experimental cell research 35 6574926
2006 Apoptosis of HL-60 cells induced by extracts from Narcissus tazetta var. chinensis. Cancer letters 33 16427186
1999 LipC, a second lipase of Pseudomonas aeruginosa, is LipB and Xcp dependent and is transcriptionally regulated by pilus biogenesis components. Molecular microbiology 29 10564475
1998 Coordinate expression of OPN and associated receptors during monocyte/macrophage differentiation of HL-60 cells. Journal of cellular physiology 29 9525482
1975 Prolonged survival in bronchogenic carcinoma associated with HL-A antigens W-19 and HL-A5: a preliminary report. Journal of the National Cancer Institute 29 1133845
2017 Environmentally Persistent Free Radicals Cause Apoptosis in HL-1 Cardiomyocytes. Cardiovascular toxicology 28 27052339
2011 Physical activity modifies the effect of LPL, LIPC, and CETP polymorphisms on HDL-C levels and the risk of myocardial infarction in women of European ancestry. Circulation. Cardiovascular genetics 28 21252145
1975 HL-A antigen, gene, and haplotype frequencies in Denmark. Tissue antigens 28 1179408
2005 Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs). Journal of cellular biochemistry 27 15578578
2004 Antiproliferation effects of oridonin on HL-60 cells. Annals of hematology 26 15322762
2001 Interaction of the common apolipoprotein C-III (APOC3 -482C > T) and hepatic lipase (LIPC -514C > T) promoter variants affects glucose tolerance in young adults. European Atherosclerosis Research Study II (EARS-II). Annals of human genetics 26 11427182
1987 HL-60-1E3, a novel phorbol diester-resistant HL-60 cell line. Cancer research 26 3028607
2022 H and HL synergistically regulate jasmonate-triggered trichome formation in tomato. Horticulture research 24 35048113
2002 The diabetes-prone NZO/Hl strain. II. Pancreatic immunopathology. Laboratory investigation; a journal of technical methods and pathology 24 12118086
2012 Toosendanin induces apoptosis through suppression of JNK signaling pathway in HL-60 cells. Toxicology in vitro : an international journal published in association with BIBRA 23 23111283
2000 Effect of coumarins on HL-60 cell differentiation. Anticancer research 23 10953319
1986 Anticoagulant activities of pentosan polysulphate (Hémoclar) due to release of hepatic triglyceride lipase (HTGL). Thrombosis and haemostasis 23 2433786
2014 AKT1 and AKT2 induce distinct phosphorylation patterns in HL-1 cardiac myocytes. Journal of proteome research 22 25162660
2009 Differential behaviour of Pseudomonas sp. 42A2 LipC, a lipase showing greater versatility than its counterpart LipA. Biochimie 22 19944735
2001 Nuclear changes in necrotic HL-60 cells. Journal of cellular biochemistry. Supplement 22 11455567
1998 The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity. Journal of lipid research 22 9684756
1997 Stimulation of osteopontin mRNA expression in HL-60 cells is independent of differentiation. Archives of biochemistry and biophysics 22 9224725
1990 DMSO and retinoic acid induce HL-60 differentiation by different but converging pathways. Experimental cell research 22 2201551
1989 Isolation and characterization of an unprocessed extracellular myeloperoxidase in HL-60 cell cultures. The Journal of biological chemistry 22 2542279
2021 Kaempferol and Its Glycoside Derivatives as Modulators of Etoposide Activity in HL-60 Cells. International journal of molecular sciences 21 33805363
2014 Hepatic lipase (LIPC) C-514T gene polymorphism is associated with cardiometabolic parameters and cardiovascular risk factors but not with fatty liver in Mexican population. Experimental and molecular pathology 20 25550127
2003 Targeting myeloperoxidase to azurophilic granules in HL-60 cells. Journal of leukocyte biology 20 12960244
2002 The loss of IAP expression during HL-60 cell differentiation is caspase-independent. Journal of leukocyte biology 20 11818445
1975 Exclusion gene mapping utilizing patients with chromosome imbalance: the HL-A system as a prototype. Humangenetik 20 1150239
2010 Association of LIPC -250G>A polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids in health and disease 19 20222961
2018 Melatonin Can Strengthen the Effect of Retinoic Acid in HL-60 Cells. International journal of molecular sciences 18 30248940
2007 A novel lipolytic enzyme, YcsK (LipC), located in the spore coat of Bacillus subtilis, is involved in spore germination. Journal of bacteriology 18 17220230
1993 Suppression of HL-60 cell proliferation by deferoxamine: changes in c-myc expression. Anticancer research 18 8517655
2021 CTSB Knockdown Inhibits Proliferation and Tumorigenesis in HL-60 Cells. International journal of medical sciences 17 33628106
2021 Genomic-Metabolomic Associations Support the Role of LIPC and Glycerophospholipids in Age-Related Macular Degeneration. Ophthalmology science 17 34382031
2012 Dimethylsulfoxide exposure modulates HL-60 cell rolling interactions. Bioscience reports 16 22494057
1998 3-Hydroxy-3-methylglutaryl-CoA lyase (HL): gene targeting causes prenatal lethality in HL-deficient mice. Human molecular genetics 16 9817922
2017 Effect of YAP Inhibition on Human Leukemia HL-60 Cells. International journal of medical sciences 15 28824329
2011 The lipase LipA (PA2862) but not LipC (PA4813) from Pseudomonas aeruginosa influences regulation of pyoverdine production and expression of the sigma factor PvdS. Journal of bacteriology 15 21840975
2006 Molecular response of leukemia HL-60 cells to genistein treatment, a proteomics study. Leukemia research 15 16616778
1993 The effects of benzene and hydroquinone on myeloid differentiation of HL-60 promyelocytic leukemia cells. Leukemia & lymphoma 15 8124204
1975 A study on HL-A system in Japanese. Tissue antigens 15 50632
2022 Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia. Circulation 14 35899625
2017 Transcriptomes reflect the phenotypes of undifferentiated, granulocyte and macrophage forms of HL-60/S4 cells. Nucleus (Austin, Tex.) 14 28152343
2015 Maintenance of HL-1 cardiomyocyte functional activity in PEGylated fibrin gels. Biotechnology and bioengineering 14 25657056
2014 NLS-RARα promotes proliferation and inhibits differentiation in HL-60 cells. International journal of medical sciences 14 24516348
2009 Diagnostic value of post-heparin lipase testing in detecting common genetic variants in the LPL and LIPC genes. European journal of human genetics : EJHG 14 19367320
2009 Cytotoxic activity of acridin-3,6-diyl dithiourea hydrochlorides in human leukemia line HL-60 and resistant subline HL-60/ADR. International journal of biological macromolecules 14 19414028
2009 Two novel mutations and functional analyses of the CETP and LIPC genes underlying severe hyperalphalipoproteinemia. Metabolism: clinical and experimental 14 19428034
1977 Cytoplasmic and HL-A antigens in the human epidermis. The British journal of dermatology 14 326294
2012 Resequencing CETP, LIPC and LIPG genes in Thai subjects with hyperalphalipoproteinemia. The American journal of cardiology 13 22464213
2022 microRNA-27b regulates hepatic lipase enzyme LIPC and reduces triglyceride degradation during hepatitis C virus infection. The Journal of biological chemistry 12 35483451
2017 Synergistic Effect of Baicalin and Adriamycin in Resistant HL-60/ADM Leukaemia Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 12 28869936
1990 Retinoic acid induced differentiation and commitment in HL-60 cells. Environmental health perspectives 12 2272312