Affinage

LIPC

Hepatic triacylglycerol lipase · UniProt P11150

Length
499 aa
Mass
55.9 kDa
Annotated
2026-06-10
72 papers in source corpus 13 papers cited in narrative 13 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 4/4 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LIPC encodes hepatic lipase, a serine hydrolase with both triglyceride lipase and phospholipase activities that is a major determinant of plasma lipoprotein metabolism, with allelic variation at the locus accounting for ~25% of variance in plasma HDL-C (PMID:9114024). Its hepatic transcription is directly controlled by HNF4α acting through DR1 and DR4 elements, co-activated by PGC-1α and HNF1α and repressed by ARP-1, with HNF4α disruption abolishing hepatic HL mRNA in vivo (PMID:16603721); common 5'-flanking promoter variants (-480C→T, -514C→T, -216G→A) reduce promoter activity, in part by lowering USF binding affinity, thereby decreasing HL expression and raising HDL-C (PMID:11257263, PMID:9114024, PMID:32617858). Loss-of-function missense variants that reduce HL enzymatic activity cause hyperalphalipoproteinemia (PMID:23219720), whereas a gain-of-function variant (E97G) that selectively enhances phospholipase activity by altering a conserved motif controlling substrate access promotes catabolism of triglyceride-rich lipoproteins and causes combined hypocholesterolemia (PMID:35899625). Beyond its secreted lipolytic role, hepatic lipase intracellularly suppresses apoA-I synthesis and secretion in hepatocytes independent of cell-surface heparan sulfate proteoglycan binding (PMID:25013403), and is post-transcriptionally downregulated by miR-27b to reduce intracellular triglyceride degradation (PMID:35483451).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1986 Medium

    Established that hepatic lipase has activities beyond lipolysis, showing purified HTGL exerts a direct anticoagulant effect in plasma.

    Evidence In vitro addition of purified HTGL to plasma with anti-Xa clotting and thrombin generation assays

    PMID:2433786

    Open questions at the time
    • Mechanism linking lipase activity to coagulation not defined
    • Physiological relevance in vivo not established
    • Older methodology, single study
  2. 1997 High

    Quantified LIPC as a major genetic determinant of HDL-C, framing the locus as physiologically dominant rather than incidental to lipid metabolism.

    Evidence Linkage analysis and sequencing with replicated association in two independent population samples

    PMID:9114024

    Open questions at the time
    • Causal variant among the linked 5'-flanking polymorphisms not pinned to a molecular mechanism
    • Did not establish which polymorphism drives the phenotype
  3. 1998 Medium

    Tested whether the HDL-associated -514 variant acts via hormonal modulation, showing its effect on HL activity is independent of androgen responsiveness.

    Evidence Stanozolol pharmacological challenge with post-heparin plasma HL activity measurement and genotyping in two ethnic groups

    PMID:9684756

    Open questions at the time
    • Did not define the molecular basis of the -514 effect
    • Single intervention, modest sample
  4. 2001 High

    Provided a molecular mechanism for promoter variants by showing -480C→T reduces USF transcription factor binding and lowers promoter activity.

    Evidence CAT-reporter assays, EMSA, and USF cDNA co-transfection in HepG2 cells

    PMID:11257263

    Open questions at the time
    • Does not establish in vivo contribution of USF occupancy to HL levels
    • Other promoter variants in linkage not individually resolved
  5. 2006 High

    Defined the core transcriptional regulatory circuit of LIPC, identifying direct HNF4α control via DR1/DR4 with PGC-1α and HNF1α activation and ARP-1 repression.

    Evidence Luciferase reporters, co-transfection, Hnf4α knockout mice, and pharmacological HNF4α antagonism

    PMID:16603721

    Open questions at the time
    • Signals that tune HNF4α/PGC-1α activity on LIPC not defined
    • Interplay with promoter SNP USF site not integrated
  6. 2009 Medium

    Linked coding LIPC variants to low HL activity and high HDL-C in patients, extending the loss-of-function genotype-phenotype relationship to the protein-coding sequence.

    Evidence Coding region sequencing and post-heparin HL activity in Thai hyperalphalipoproteinemia subjects

    PMID:19428034

    Open questions at the time
    • No in vitro reconstitution of the specific variants
    • Functional relevance inferred from conservation, not assayed directly
  7. 2012 High

    Confirmed causality of loss-of-function missense variants by reconstituting reduced enzymatic activity in cells.

    Evidence Site-directed mutagenesis and HL activity assays in HepG2 cell lysates

    PMID:23219720

    Open questions at the time
    • Effect on secretion versus catalysis not separated
    • Substrate-specific (TG vs phospholipid) consequences not measured
  8. 2014 Medium

    Revealed a non-canonical intracellular role, showing hepatic lipase suppresses apoA-I synthesis independent of cell-surface HSPG binding.

    Evidence Adenoviral expression in Lipc-null primary hepatocytes with 35S metabolic labeling and subcellular fractionation

    PMID:25013403

    Open questions at the time
    • Molecular mechanism of intracellular apoA-I suppression unknown
    • Whether catalytic activity is required not resolved
    • Single lab
  9. 2021 Low

    Associated LIPC genetic variation with plasma glycerophospholipid (phosphatidylethanolamine) levels, hinting at a phospholipid-handling role at the population level.

    Evidence Metabolite QTL analysis with mass spectrometry metabolomics and SNP arrays across two cohorts

    PMID:34382031

    Open questions at the time
    • No direct enzymatic or biochemical experiment on the protein
    • Association does not establish causal flux through HL
    • Confounding by linkage not excluded
  10. 2022 High

    Dissected the dual catalytic activities, showing a gain-of-function E97G variant selectively boosts phospholipase activity via a conserved substrate-access motif and causes combined hypocholesterolemia.

    Evidence Homology modeling, in vitro phospholipase/TG lipase assays, APOE*3-Leiden.CETP overexpression mice, NMR lipoprotein profiling and lipidomics

    PMID:35899625

    Open questions at the time
    • Structural model not validated by crystallography
    • Extrahepatic clearance pathway not mechanistically mapped
  11. 2022 Medium

    Identified post-transcriptional control of LIPC by miR-27b linking it to intracellular triglyceride turnover and HCV biology.

    Evidence Activity-based serine hydrolase proteomics, SILAC mass spectrometry, miRNA mimic/inhibitor, and HCV infection assays

    PMID:35483451

    Open questions at the time
    • Direct miR-27b:LIPC target site not mapped functionally
    • In vivo relevance of regulation not shown
  12. 2022 Medium

    Placed LIPC in a tumor-suppressive axis, showing TUSC3 physically interacts with and positively regulates LIPC to restrain AKT-driven EMT in hepatocellular carcinoma.

    Evidence Co-immunoprecipitation, immunofluorescence, and gain/loss-of-function experiments in vitro and in vivo

    PMID:36274132

    Open questions at the time
    • Whether HL catalytic activity mediates the anti-EMT effect unknown
    • Single Co-IP without reciprocal structural mapping
    • Mechanism linking LIPC to AKT not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the secreted lipolytic, intracellular apoA-I-suppressing, and tumor-suppressive functions of hepatic lipase are integrated, and how catalytic versus non-catalytic activities partition across these roles, remains unresolved.
  • No structural model linking the two catalytic activities to distinct physiological outputs
  • Catalytic requirement for intracellular and tumor-related functions untested
  • Tissue-specific regulation of the dual activities undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016787 hydrolase activity 3
Localization
GO:0005576 extracellular region 1 GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-1430728 Metabolism 2 R-HSA-74160 Gene expression (Transcription) 2
Partners
HNF1AHNF4APPARGC1ATUSC3USF1

Evidence

Reading pass · 13 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 The common -216G→A and -480C→T substitutions in the LIPC promoter reduce promoter activity by ~45% in HepG2 cells. The -480C→T substitution decreases binding affinity of Upstream Stimulatory Factor (USF) protein to its binding site by four-fold, as shown by gel-shift assays. Co-transfection with USF(43) cDNA increases activity of all -650/+48 constructs dose-dependently, maintaining the relative difference between variant and wild-type promoters. CAT-reporter assays in HepG2 cells, gel-shift (EMSA) assays, co-transfection with USF cDNA Atherosclerosis High 11257263
2006 The LIPC promoter is directly regulated by HNF4α via two newly identified direct repeat elements (DR1 and DR4). PGC-1α co-activates HNF4α-dependent LIPC transcription. ARP-1 displaces HNF4α from the DR1 site and represses LIPC promoter activity. HNF1α activates LIPC transcription through its binding site and has an additive effect with HNF4α. In vivo, disruption of Hnf4α in mice abolishes hepatic HL mRNA expression, and the HNF4α antagonist Medica 16 represses endogenous LIPC mRNA in cells. Luciferase reporter assays, co-transfection experiments in HepG2 cells, Hnf4α knockout mice, RT-PCR for endogenous mRNA Journal of lipid research High 16603721
2022 A gain-of-function LIPC variant (E97G) specifically increases the phospholipase activity of hepatic lipase (without altering triglyceride lipase activity) by modifying an evolutionarily conserved motif that controls substrate access to the catalytic site. In vitro cell culture and in vivo mouse overexpression studies showed the increased phospholipase activity promotes catabolism of triglyceride-rich lipoproteins by extrahepatic tissues, resulting in combined hypocholesterolemia (low LDL-C and HDL-C). The lysophospholipid/phospholipid ratio was elevated in plasma of variant carriers, consistent with increased phospholipase activity. Protein homology modeling, in vitro phospholipase and triglyceride lipase activity assays in cell culture, APOE*3-Leiden.CETP mouse overexpression model, NMR-based lipoprotein profiling, lipidomics Circulation High 35899625
2009 Two novel LIPC missense variants (G119S/c.421G>A and previously known V73M/L334F) were identified in Thai subjects with hyperalphalipoproteinemia and low hepatic lipase activity, supporting that loss-of-function variants in LIPC cause elevated HDL-C. The G119S variant was judged functionally relevant based on evolutionary conservation and location in a functionally important domain. Genetic sequencing of LIPC coding regions, measurement of post-heparin hepatic lipase activity in patient plasma Metabolism: clinical and experimental Medium 19428034
2012 Two novel LIPC missense variants (p.G141S/c.421A>G and p.V173M/c.517G>A) reduce hepatic lipase activity in HepG2 cell lysates to 41% and 46% of wild-type, respectively, confirming their loss-of-function effect underlying hyperalphalipoproteinemia. Site-directed mutagenesis, cDNA cloning and transient expression in HepG2 cells, hepatic lipase activity assay in cell lysates Clinica chimica acta High 23219720
2014 Expression of human hepatic lipase (hHL) in primary hepatocytes from Lipc-null mice decreased synthesis and secretion of apoA-I (but not apoE), as shown by metabolic labeling. An HSPG-binding deficient hHL mutant (hHLmt) also inhibited apoA-I production despite impaired ER exit, and both hHL and hHLmt increased microsome-associated apoA-I, indicating an intracellular mechanism for HL's negative impact on apoA-I production independent of cell-surface binding. Adenovirus-mediated gene transfer in Lipc-null primary hepatocytes, metabolic labeling with 35S, subcellular fractionation Journal of biomedical research Medium 25013403
2022 miR-27b negatively regulates LIPC expression and activity in hepatocytes. Using activity-based protein profiling with a serine hydrolase probe and stable isotope labeling/mass spectrometry, LIPC was identified as a direct target of miR-27b. Modulation of miR-27b with mimics or inhibitors altered LIPC levels. Transcription factors Jun, PPARα, and HNF4α (which also regulate LIPC) are themselves regulated by miR-27b. LIPC knockdown decreased intracellular triglyceride degradation and affected HCV life cycle progression. Activity-based protein profiling with serine hydrolase probe, SILAC mass spectrometry, miRNA mimic/inhibitor transfection, cell-based HCV infection assay The Journal of biological chemistry Medium 35483451
1998 The -514T allele of LIPC is associated with decreased post-heparin hepatic lipase activity in both white and African American men, and this effect is independent of androgen action. Treatment with the anabolic steroid stanozolol increased hepatic lipase activity equally in -514T and -514C homozygous men (45 vs 51 mmol·hr⁻¹·l⁻¹, P=0.5), demonstrating the polymorphism does not modulate androgen responsiveness of HL. Pharmacological challenge (stanozolol treatment), post-heparin plasma hepatic lipase activity measurement, genotyping Journal of lipid research Medium 9684756
1997 Linkage analysis in 218 nuclear families showed that allelic variation at or near the LIPC gene accounts for ~25% of variance in plasma HDL-C concentrations. Sequencing identified four novel 5'-flanking polymorphisms in complete linkage disequilibrium (a single allele) associated with higher HDL-C and apolipoprotein AI levels, establishing LIPC genetic variation as a major determinant of plasma HDL-C. Linkage analysis, DNA sequencing, association studies in two independent population samples Proceedings of the National Academy of Sciences of the United States of America High 9114024
2022 TUSC3 negatively regulates LIPC expression in hepatocellular carcinoma. Co-immunoprecipitation showed a physical interaction between TUSC3 and LIPC. Loss of TUSC3 reduces LIPC levels and activates AKT signaling, promoting epithelial-mesenchymal transition (EMT). Gain- and loss-of-function experiments showed LIPC negatively modulates HCC cell proliferation and migration, acting downstream of TUSC3 to suppress AKT-driven EMT. Co-immunoprecipitation, immunofluorescence, loss-of-function and gain-of-function experiments in vitro and in vivo, Western blot for EMT markers and AKT pathway Journal of translational medicine Medium 36274132
2020 The LIPC -514C→T promoter variant reduces LIPC promoter activity by ~90% in a luciferase reporter assay in HepG2 cells, providing a direct functional explanation for its association with decreased hepatic lipase activity and increased HDL-C levels. Luciferase reporter assay in HepG2 cells Journal of endocrinological investigation Medium 32617858
1986 Purified hepatic triglyceride lipase (HTGL/hepatic lipase) added to plasma markedly enhanced anti-Factor Xa clotting activity and caused ~70% inhibition of lipid peroxide-induced thrombin generation in vitro, demonstrating a direct anticoagulant function for HTGL in plasma. In vitro addition of purified HTGL to plasma, anti-Xa clotting activity assay, thrombin generation assay Thrombosis and haemostasis Medium 2433786
2021 LIPC gene polymorphisms are associated with plasma phosphatidylethanolamine metabolite levels (glycerophospholipids), as identified by metabolite quantitative trait loci (met-QTL) analysis in AMD patients and controls, supporting a role for LIPC in glycerophospholipid metabolism. Metabolite QTL analysis using mass spectrometry metabolomics and Illumina SNP array, linear regression, meta-analysis across two cohorts Ophthalmology science Low 34382031

Source papers

Stage 0 corpus · 72 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proceedings of the National Academy of Sciences of the United States of America 378 20385826
1997 A hepatic lipase (LIPC) allele associated with high plasma concentrations of high density lipoprotein cholesterol. Proceedings of the National Academy of Sciences of the United States of America 220 9114024
1998 Hepatic lipase activity is lower in African American men than in white American men: effects of 5' flanking polymorphism in the hepatic lipase gene (LIPC). Journal of lipid research 125 9469601
2011 Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration. Investigative ophthalmology & visual science 104 21447678
1995 The three genes lipB, lipC, and lipD involved in the extracellular secretion of the Serratia marcescens lipase which lacks an N-terminal signal peptide. Journal of bacteriology 79 7592412
2001 Hepatic lipase promoter activity is reduced by the C-480T and G-216A substitutions present in the common LIPC gene variant, and is increased by Upstream Stimulatory Factor. Atherosclerosis 61 11257263
2010 Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration. Molecular vision 56 21139980
1999 Absence of association between genetic variation in the LIPC gene promoter and plasma lipoproteins in three Canadian populations. Atherosclerosis 49 10487498
2002 A common promoter polymorphism in the hepatic lipase gene (LIPC-480C>T) is associated with an increase in coronary calcification in type 1 diabetes. Diabetes 48 11916946
1998 Body mass index and hepatic lipase gene (LIPC) polymorphism jointly influence postheparin plasma hepatic lipase activity. Journal of lipid research 48 9610782
2015 CETP/LPL/LIPC gene polymorphisms and susceptibility to age-related macular degeneration. Scientific reports 44 26503844
2011 LipC (Rv0220) is an immunogenic cell surface esterase of Mycobacterium tuberculosis. Infection and immunity 43 22038913
2010 Lipase LipC affects motility, biofilm formation and rhamnolipid production in Pseudomonas aeruginosa. FEMS microbiology letters 43 20546309
2006 Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter. Journal of lipid research 41 16603721
2003 Atorvastatin dose-dependently decreases hepatic lipase activity in type 2 diabetes: effect of sex and the LIPC promoter variant. Diabetes care 40 12547874
2012 Association studies of several cholesterol-related genes (ABCA1, CETP and LIPC) with serum lipids and risk of Alzheimer's disease. Lipids in health and disease 39 23181436
2003 Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD. BMC medical genetics 37 12964943
2003 Ethnic differences in hepatic lipase and HDL in Japanese, black, and white Americans: role of central obesity and LIPC polymorphisms. Journal of lipid research 30 14657196
2015 Dietary Fat Intake Modifies the Effect of a Common Variant in the LIPC Gene on Changes in Serum Lipid Concentrations during a Long-Term Weight-Loss Intervention Trial. The Journal of nutrition 29 25926410
1999 LipC, a second lipase of Pseudomonas aeruginosa, is LipB and Xcp dependent and is transcriptionally regulated by pilus biogenesis components. Molecular microbiology 29 10564475
2011 Physical activity modifies the effect of LPL, LIPC, and CETP polymorphisms on HDL-C levels and the risk of myocardial infarction in women of European ancestry. Circulation. Cardiovascular genetics 28 21252145
2010 Association between CETP Taq1B and LIPC -514C/T polymorphisms with the serum lipid levels in a group of Tehran's population: a cross sectional study. Lipids in health and disease 26 20822508
2001 Interaction of the common apolipoprotein C-III (APOC3 -482C > T) and hepatic lipase (LIPC -514C > T) promoter variants affects glucose tolerance in young adults. European Atherosclerosis Research Study II (EARS-II). Annals of human genetics 26 11427182
1986 Anticoagulant activities of pentosan polysulphate (Hémoclar) due to release of hepatic triglyceride lipase (HTGL). Thrombosis and haemostasis 23 2433786
2009 Differential behaviour of Pseudomonas sp. 42A2 LipC, a lipase showing greater versatility than its counterpart LipA. Biochimie 22 19944735
1998 The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity. Journal of lipid research 22 9684756
2014 Hepatic lipase (LIPC) C-514T gene polymorphism is associated with cardiometabolic parameters and cardiovascular risk factors but not with fatty liver in Mexican population. Experimental and molecular pathology 21 25550127
2002 Loci for CETP, LPL, LIPC, and APOC3 affect plasma lipoprotein size and sub-population distribution in Hispanic and non-Hispanic white subjects: the Columbia University BioMarkers Study. Nutrition, metabolism, and cardiovascular diseases : NMCD 20 12514935
2010 Association of LIPC -250G>A polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids in health and disease 19 20222961
2007 A novel lipolytic enzyme, YcsK (LipC), located in the spore coat of Bacillus subtilis, is involved in spore germination. Journal of bacteriology 18 17220230
2021 Genomic-Metabolomic Associations Support the Role of LIPC and Glycerophospholipids in Age-Related Macular Degeneration. Ophthalmology science 17 34382031
2002 Sources of variability in genetic association studies: insights from the analysis of hepatic lipase (LIPC). Human mutation 17 11968086
2022 Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia. Circulation 16 35899625
2011 The lipase LipA (PA2862) but not LipC (PA4813) from Pseudomonas aeruginosa influences regulation of pyoverdine production and expression of the sigma factor PvdS. Journal of bacteriology 15 21840975
2009 Two novel mutations and functional analyses of the CETP and LIPC genes underlying severe hyperalphalipoproteinemia. Metabolism: clinical and experimental 15 19428034
2014 Comparative studies of zebrafish Danio rerio lipoprotein lipase (lpl) and hepatic lipase (lipc) genes belonging to the lipase gene family: evolution and expression pattern. Journal of fish biology 14 24905963
2012 Association of CETP and LIPC Gene Polymorphisms with HDL and LDL Sub-fraction Levels in a Group of Indian Subjects: A Cross-Sectional Study. Indian journal of clinical biochemistry : IJCB 14 24426196
2009 Diagnostic value of post-heparin lipase testing in detecting common genetic variants in the LPL and LIPC genes. European journal of human genetics : EJHG 14 19367320
2012 Resequencing CETP, LIPC and LIPG genes in Thai subjects with hyperalphalipoproteinemia. The American journal of cardiology 13 22464213
2022 microRNA-27b regulates hepatic lipase enzyme LIPC and reduces triglyceride degradation during hepatitis C virus infection. The Journal of biological chemistry 12 35483451
2020 The -514C>T polymorphism in the LIPC gene modifies type 2 diabetes risk through modulation of HDL-cholesterol levels in Mexicans. Journal of endocrinological investigation 12 32617858
2020 The Effect of Haplotypes in the CETP and LIPC Genes on the Triglycerides to HDL-C Ratio and Its Components in the Roma and Hungarian General Populations. Genes 11 31947886
2018 SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, LIPC rs10468017, rs493258 and LPL rs12678919 genotypes and haplotype evaluation in patients with age-related macular degeneration. Gene 11 30399423
2017 Serum Levels of TIMP-3, LIPC, IER3, and SLC16A8 in CFH-Negative AMD Cases. Journal of cellular biochemistry 11 27966779
2013 Multi-locus candidate gene analyses of lipid levels in a pediatric Turkish cohort: lessons learned on LPL, CETP, LIPC, ABCA1, and SHBG. Omics : a journal of integrative biology 11 23988150
2008 LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion. Atherosclerosis 11 19101670
2020 A study of associations between CUBN, HNF1A, and LIPC gene polymorphisms and coronary artery disease. Scientific reports 10 33004870
2019 CETP, LIPC, and SCARB1 variants in individuals with extremely high high-density lipoprotein-cholesterol levels. Scientific reports 10 31358896
2015 Gender specific effect of LIPC C-514T polymorphism on obesity and relationship with plasma lipid levels in Chinese children. Journal of cellular and molecular medicine 9 26282880
2005 Interaction between insulin (VNTR) and hepatic lipase (LIPC-514C>T) variants on the response to an oral glucose tolerance test in the EARSII group of young healthy men. Biochimica et biophysica acta 9 15949705
2004 Association of the -514C-->T polymorphism in the hepatic lipase gene (LIPC) promoter with elevated fasting insulin concentrations, but not insulin resistance, in non-diabetic Germans. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 9 15156410
2020 Hepatic lipase (LIPC) sequencing in individuals with extremely high and low high-density lipoprotein cholesterol levels. PloS one 8 33326441
2009 Gene polymorphisms in APOE, NOS3, and LIPC genes may be risk factors for cardiac adverse events after primary CABG. Journal of cardiothoracic surgery 8 19691831
2022 Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma progression through LIPC/AKT axis. Journal of translational medicine 7 36274132
2010 Bacillus subtilis spore coat protein LipC is a phospholipase B. Bioscience, biotechnology, and biochemistry 7 20057119
2014 Variants -250G/A and -514C/T in the LIPC gene are associated with hypertensive disorders of pregnancy in Chinese women. Genetics and molecular research : GMR 6 25117371
2018 Association of LIPC -250G/A and -514C/T polymorphisms and hypertension: a systematic review and meta-analysis. Lipids in health and disease 5 30322388
2007 Association of an intronic haplotype of the LIPC gene with hyperalphalipoproteinemia in two independent populations. Journal of human genetics 5 18160998
2020 Increased Expression of LIPC Is Associated with Aggressive Phenotype of Borrmann Type 4 Gastric Cancer. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 4 32157605
2024 Phenotype in Individuals with Heterozygous Rare Variants in LIPC Encoding Hepatic Lipase. International journal of molecular sciences 3 39518997
2013 Lack of association between LIPC-514 C/T polymorphism of hepatic lipase and endometriosis in Iranian women. The journal of obstetrics and gynaecology research 3 24124978
2023 Increased Expression of LIPC Is Associated With the Clinicopathological Features and Development of Head and Neck Squamous Cell Carcinoma. Cureus 2 38192945
2022 Hypertriglyceridemia Induced Acute Pancreatitis Caused by a Novel LIPC Gene Variant in a Pediatric Patient. Children (Basel, Switzerland) 2 35204909
2014 Expression of human hepatic lipase negatively impacts apolipoprotein A-I production in primary hepatocytes from Lipc-null mice. Journal of biomedical research 2 25013403
2012 Functional characterization of novel variants in the CETP promoter and the LIPC gene in subjects with hyperalphalipoproteinemia. Clinica chimica acta; international journal of clinical chemistry 2 23219720
2023 Association of LIPC polymorphisms with stroke risk in the Chinese population. Frontiers in neurology 1 37273686
2018 Association of the LIPC rs1532085 SNP and serum lipid traits in the Chinese Maonan and Han populations. International journal of clinical and experimental pathology 1 31938311
2013 [The association study of the LIPC -250g/A polymorphism and high-carbohydrate/low-fat diet induced serum lipid and apolipoprotein concentration changes in healthy youth]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 1 24325099
2023 [Identification and 3D architecture analysis of the LIPC gene mutation in a pedigree with familial hypercholesterolemia-like phenotype]. Zhonghua xin xue guan bing za zhi 0 37460425
2023 Olive oil increases the LIPC expression when associated with an Eastern pattern diet: An experimental study with Wistar rats. Gene 0 37625559
2011 A novel porcine gene, LIPC, differentially expressed in the liver tissues from Meishan and Large White pigs. Journal of applied genetics 0 21327595
1997 Assignment of the cellular retinol binding protein 1 (Rbp1) and hepatic lipase (Lipc) genes to rat chromosome 8. Folia biologica 0 9338114

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