Affinage

LARP6

La-related protein 6 · UniProt Q9BRS8

Length
491 aa
Mass
54.7 kDa
Annotated
2026-04-28
37 papers in source corpus 16 papers cited in narrative 16 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LARP6 is an RNA-binding protein that orchestrates collagen biosynthesis by sequence-specifically recognizing a conserved 5′ stem-loop (5′SL) in the 5′UTR of type I and type III collagen mRNAs and directing their coordinated translation at the ER membrane. High-affinity 5′SL recognition (~1.4 nM Kd) is conferred by an RNK motif within the La domain, with the adjacent RRM1 stabilizing the complex and an N-terminal intrinsically disordered region restricting RNA-binding selectivity; LARP6 targets collagen mRNAs to SEC61 translocons via its RRM loop 3 and cooperates with nonmuscle myosin filaments to partition these mRNAs at the ER independently of translation (PMID:19917293, PMID:25488812, PMID:34896113, PMID:25692237, PMID:25271881, PMID:41714637). LARP6 activity is tuned by hierarchical phosphorylation—Akt at S451 and mTORC1 at S348/S409—which regulates interaction with the accessory protein STRAP, ER membrane cycling, and proper collagen folding and secretion (PMID:26932461, PMID:28112218). Beyond collagen, LARP6 functions in ciliogenesis by binding α-tubulin mRNA within DNAAF6-containing biomolecular condensates in multiciliated cells, and genome-wide eCLIP/iCLIP studies reveal it interacts with hundreds of mRNAs, regulating translation and alternative splicing in contexts including hepatic stellate cell activation and cancer (PMID:38762183, PMID:41746718, PMID:40050364).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2009 High

    Establishing that LARP6 is a sequence-specific collagen mRNA-binding protein resolved how type I collagen mRNAs are distinguished from bulk mRNAs for specialized translational regulation at the ER.

    Evidence Biochemical binding assays (Kd ~1.4 nM), siRNA knockdown, polysome fractionation, and collagen-GFP reporter imaging in human fibroblasts

    PMID:19917293

    Open questions at the time
    • Structural basis of 5′SL recognition unknown
    • Mechanism coupling LARP6 binding to ER membrane targeting not addressed
    • Physiological relevance in vivo not tested
  2. 2013 Medium

    Identification of FKBP3 as a LARP6-interacting protein showed that accessory factors modulate collagen mRNA engagement, and that pharmacological disruption (FK506) of this interaction blocks fibrosis in vivo.

    Evidence Co-immunoprecipitation, RNA pull-down, and in vivo fibrosis model with FK506 treatment

    PMID:23755290

    Open questions at the time
    • Direct vs. bridged interaction between FKBP3 and LARP6 not resolved
    • Single-lab observation without independent replication
  3. 2014 High

    Structural and mutagenesis studies defined the bipartite La–RRM1 architecture required for 5′SL recognition and simultaneously revealed that LARP6 bridges collagen mRNAs to SEC61 translocons and the ER membrane via nonmuscle myosin filaments, establishing the mechanism of mRNA-to-translocon targeting.

    Evidence X-ray/NMR structures of LaM and RRM1, mutagenesis, gel-shift assays, dominant-negative SEC61-interaction-deficient mutant, subcellular fractionation, and myosin depolymerization in fibroblasts

    PMID:25271881 PMID:25488812 PMID:25692237

    Open questions at the time
    • No co-crystal structure of LARP6 bound to 5′SL RNA
    • Direct binding interface between LARP6 and SEC61 not mapped at residue level
    • Role of nonmuscle myosin remains correlative
  4. 2014 High

    Showing that IGF-1 stimulates collagen synthesis through PI3K/Akt-dependent increase in LARP6 expression and collagen mRNA loading placed LARP6 downstream of growth factor signaling.

    Evidence RIP-qPCR, 5′SL mutation and RNA decoy sequestration, PI3K/Akt pathway inhibitors in fibroblasts

    PMID:24469459

    Open questions at the time
    • Transcriptional vs. post-transcriptional regulation of LARP6 levels by IGF-1 not fully dissected
  5. 2016 High

    Mapping Akt phosphorylation of LARP6 at S451 as a hierarchical prerequisite for subsequent phosphorylation events established that post-translational modification directly controls collagen folding and secretion quality.

    Evidence Mass spectrometry phosphosite mapping, PI3K/Akt inhibitors, S451A dominant-negative mutant, pulse-chase secretion assay in lung fibroblasts

    PMID:26932461

    Open questions at the time
    • Identity of downstream kinases phosphorylating other serines (beyond mTORC1) not fully resolved
    • Phosphorylation-dependent structural changes in LARP6 not characterized
  6. 2017 High

    Demonstrating mTORC1-dependent phosphorylation at S348/S409 explained how LARP6 cycles between ER-bound collagen mRNA complexes and soluble forms, coupling nutrient sensing to collagen production.

    Evidence Rapamycin treatment, raptor knockdown, S348A/S409A dominant-negative mutant, co-IP with STRAP, subcellular fractionation

    PMID:28112218

    Open questions at the time
    • Temporal order of Akt vs. mTORC1 phosphorylation in a single translation cycle not resolved
    • STRAP's molecular role in translation coordination unclear
  7. 2021 High

    Pinpointing the RNK motif in the La domain as necessary and sufficient for 5′SL recognition refined the binding model and explained why other LARP family members cannot bind collagen mRNAs.

    Evidence UV-crosslinking mapping, domain deletion, mutagenesis, and RNA binding assays

    PMID:34896113

    Open questions at the time
    • Atomic-resolution structure of the RNK–5′SL interface not yet available from peer-reviewed work
  8. 2021 High

    Discovery that the prostaglandin D2 receptor CRTH2 binds LARP6's collagen mRNA recognition site and promotes collagen mRNA degradation identified an upstream negative regulator, with genetic epistasis confirming LARP6 as the downstream effector in fibrosis.

    Evidence Co-IP, CRTH2/LARP6 double depletion epistasis, caveolin-1-dependent trafficking, CRTH2 knockout mouse fibrosis model

    PMID:34223653

    Open questions at the time
    • Mechanism by which CRTH2 binding to LARP6 triggers mRNA degradation unresolved
    • Whether CRTH2–LARP6 interaction occurs on all collagen mRNA targets not tested
  9. 2023 Medium

    Identification of ZNF267 mRNA as a non-collagen LARP6 target in colorectal cancer demonstrated LARP6 regulates mRNA stability and translation beyond collagens, linking it to ceramide/sphingomyelin balance and autophagy.

    Evidence RIP-seq, RIP-qPCR, stable knockdown/overexpression, mRNA stability and autophagy assays in CRC cells

    PMID:36691044

    Open questions at the time
    • Whether LARP6 binds ZNF267 mRNA via a stem-loop analogous to collagen 5′SL is unknown
    • Single-lab finding not independently replicated
  10. 2024 Medium

    Showing that LARP6 localizes to DNAAF6-containing biomolecular condensates and binds α-tubulin mRNA in multiciliated cells extended LARP6 function to ciliogenesis, independent of collagen.

    Evidence Co-localization, co-IP, RNA binding assay, and DNAAF6 morphant rescue with binding-deficient mutant in Xenopus MCCs

    PMID:38762183

    Open questions at the time
    • RNA element in α-tubulin mRNA recognized by LARP6 not mapped
    • Whether LARP6 functions in mammalian ciliogenesis not tested
  11. 2025 High

    Demonstrating that the N-terminal IDR restricts LARP6 RNA-binding selectivity and is required for cancer cell viability and invasion established a regulatory mechanism that explains how LARP6 discriminates among potential mRNA targets.

    Evidence In-cell MS RNA interaction mapping, iCLIP, IDR deletion mutagenesis, cancer cell invasion/viability assays

    PMID:41714637

    Open questions at the time
    • Structural basis of IDR–La module interaction not resolved at atomic level
    • Whether IDR-mediated selectivity operates in normal (non-cancer) physiology not tested
  12. 2025 Medium

    iRIP-seq in breast cancer cells revealed LARP6 binds a CGACGAG motif on >1000 mRNAs and regulates alternative splicing, expanding its functional repertoire beyond translational control.

    Evidence iRIP-seq with motif discovery, RNA-seq, RT-qPCR in MDA-MB-231 cells

    PMID:40050364

    Open questions at the time
    • Mechanism by which an RNA-binding protein regulates splicing not elucidated
    • Overlap between iRIP-seq and eCLIP targets from other studies not assessed
  13. 2026 High

    Genome-wide eCLIP and ribosome profiling in activated hepatic stellate cells showed LARP6 interacts with >300 mRNAs and controls their translation, confirming broad translational regulatory scope in a disease-relevant fibrotic context.

    Evidence eCLIP, ribosome profiling, IP-mass spectrometry, snRNA-seq, ATAC-seq, HSC-specific siRNA knockdown

    PMID:41746718

    Open questions at the time
    • Rules distinguishing translationally regulated from non-regulated LARP6-bound mRNAs unknown
    • Contribution of individual non-collagen targets to fibrosis phenotype not dissected

Open questions

Synthesis pass · forward-looking unresolved questions
  • A peer-reviewed atomic-resolution structure of the LARP6 La domain bound to 5′SL RNA and the mechanism by which LARP6 regulates alternative splicing remain to be established.
  • No peer-reviewed co-structure of LARP6–5′SL complex
  • Splicing regulatory mechanism entirely uncharacterized
  • How LARP6 selectivity for collagen vs. non-collagen targets is determined genome-wide is unclear

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 9 GO:0098772 molecular function regulator activity 4
Localization
GO:0005783 endoplasmic reticulum 3 GO:0005829 cytosol 2
Pathway
R-HSA-392499 Metabolism of proteins 5 R-HSA-1474244 Extracellular matrix organization 3 R-HSA-162582 Signal Transduction 3 R-HSA-8953854 Metabolism of RNA 2 R-HSA-1852241 Organelle biogenesis and maintenance 1
Partners
CRTH2DNAAF6FKBP3MYH9SEC61A1STRAP

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2009 LARP6 binds the conserved 5' stem-loop (5'SL) in the 5'UTR of type I collagen mRNAs (COL1A1 and COL1A2) in a sequence-specific manner with Kd ~1.4 nM, using a bipartite RNA binding domain (La motif + RRM) that contacts two single-stranded regions of the stem-loop. In the cytoplasm, LARP6 does not associate with polysomes; overexpression blocks ribosomal loading on collagen mRNAs, while knockdown also decreases polysomal loading. LARP6 activity is required for focal synthesis of collagen polypeptides at discrete ER regions. Cloning and biochemical binding assays (Kd determination), siRNA knockdown, polysome fractionation, collagen-GFP reporter imaging Journal of molecular biology High 19917293
2014 LARP6 requires synergy between its La motif (LaM) and RRM1, as well as the interdomain linker, for sequence-specific recognition of the collagen 5'SL RNA. Crystal/NMR structures of the LaM and RRM1 of human LARP6 revealed considerable structural variation from the prototypic La protein and an unprecedented fold for the RRM1; mutagenesis guided by the structures confirmed that neither domain alone is sufficient. X-ray crystallography/NMR structure determination, mutagenesis, RNA binding assays Nucleic acids research High 25488812
2014 Five specific nucleotides within the single-stranded regions of the collagen 5'SL are critical for high-affinity LARP6 binding (mutation of individual nucleotides abolishes binding). T133 in the La domain is critical for protein folding, and loop 3 in the RRM is critical for 5'SL binding. Loop 3 also mediates interaction of LARP6 with the protein translocation channel SEC61; a LARP6 mutant that binds 5'SL but cannot interact with SEC61 acts as a dominant negative suppressor of collagen synthesis, indicating LARP6 targets collagen mRNAs to SEC61 translocons for coordinated translation. Gel mobility shift assay, mutagenesis, co-immunoprecipitation, dominant-negative overexpression RNA biology High 25692237
2014 LARP6 associates with collagen mRNAs at the ER membrane independently of translation (collagen mRNAs remain ER-associated even when translation is inhibited). Knockdown of LARP6 or depolymerization of nonmuscle myosin filaments releases collagen mRNAs from the ER membrane and causes hypermodification, poor secretion, and cytosolic accumulation of collagen polypeptides, indicating LARP6 and nonmuscle myosin cooperate to partition collagen mRNAs to the ER membrane prior to signal peptide synthesis for coordinated translation initiation. Subcellular fractionation, siRNA knockdown, nonmuscle myosin depolymerization, pulse-chase secretion assay PloS one High 25271881
2013 FKBP3 (FK506 binding protein 3, also called FKBP25) interacts with LARP6 and co-precipitates collagen mRNAs. FK506 (tacrolimus) weakens the FKBP3–LARP6 interaction and reduces pull-down of collagen mRNAs with FKBP3, leading to aberrant translation of collagen mRNAs and prevention of collagen synthesis and fibrosis in vivo. Co-immunoprecipitation, pull-down of RNA, in vivo fibrosis model PloS one Medium 23755290
2016 LARP6 is phosphorylated at S451 by the PI3K/Akt pathway in lung fibroblasts, and this phosphorylation is a prerequisite for phosphorylation at other serines (hierarchical order). S451A dominant-negative mutant drastically reduces collagen secretion and induces hypermodification of collagen α2(I) polypeptides, establishing Akt-mediated phosphorylation of LARP6 as critical for regulating translation and folding of collagen polypeptides. Mass spectrometry phosphorylation mapping, PI3K/Akt pathway inhibitors, dominant-negative overexpression, pulse-chase secretion assay, mutagenesis Scientific reports High 26932461
2017 mTORC1 phosphorylates LARP6 on S348 and S409. The S348A/S409A double mutant acts as a dominant negative in collagen biosynthesis, retards secretion, and causes excessive posttranslational modifications. mTORC1 phosphorylation of LARP6 promotes its interaction with the accessory protein STRAP (needed for coordinated translation of collagen mRNAs) and releases LARP6 from the ER membrane, enabling a new round of translation. mTORC1 inhibitor (rapamycin), raptor knockdown, dominant-negative overexpression, co-immunoprecipitation with STRAP, subcellular fractionation Scientific reports High 28112218
2014 IGF-1 increases LARP6 expression and the level of COL1A1 and COL1A2 mRNA bound to LARP6 via PI3K/Akt/p70S6k signaling. Mutation of the 5'SL of Col1a1 mRNA (which inhibits LARP6 binding) or sequestration of LARP6 with a decoy RNA abolishes IGF-1-stimulated collagen type I synthesis, confirming that LARP6 binding to collagen mRNAs is essential for IGF-1's effect on collagen production. RNA immunoprecipitation (RIP) + qPCR, 5'SL mutation, RNA decoy sequestration, PI3K/Akt pathway inhibitors The Journal of biological chemistry High 24469459
2021 The La domain of LARP6 alone is necessary and sufficient for sequence-specific recognition of the collagen 5'SL RNA. A three-amino-acid RNK motif in the flexible loop connecting the second α-helix to the β-sheet of the La domain is critical for binding; mutation of any of these three residues abolishes binding. The RRM increases stability of the La domain–5'SL complex but does not make extensive contacts with 5'SL. The RNK motif is absent from other LARPs that cannot bind 5'SL. Mutagenesis, UV-crosslinking mapping, RNA binding assays, domain-deletion analysis Journal of molecular biology High 34896113
2021 CRTH2 (a prostaglandin D2 receptor), trafficked to the ER membrane in fibroblasts in a caveolin-1-dependent manner, binds the collagen mRNA recognition motif of LARP6 and promotes degradation of collagen mRNA. CRTH2 deficiency increases collagen biosynthesis and exacerbates fibrosis in mice, which is rescued by LARP6 depletion, placing CRTH2 as an upstream negative regulator of LARP6 function. Co-immunoprecipitation, caveolin-1-dependent trafficking assay, CRTH2 and LARP6 knockdown/knockout mouse models, epistasis The EMBO journal High 34223653
2024 In Xenopus multiciliated cells (MCCs), LARP6 co-localizes with DNAAF6 in biomolecular condensates (dynein axonemal particles) and the two proteins synergize to control ciliogenesis. LARP6 binds tubulin alpha 1c-like mRNA encoding α-tubulin, a major ciliary axoneme component; a DNAAF6 mutant that cannot bind LARP6 fails to restore α-tubulin protein expression at the apical side of MCCs, demonstrating that the LARP6–DNAAF6 interaction in condensates regulates α-tubulin production during ciliogenesis. Co-localization in Xenopus embryo MCCs, co-immunoprecipitation, RNA binding assay, DNAAF6 morphant rescue with wild-type vs. binding-deficient mutant The Journal of biological chemistry Medium 38762183
2025 An intrinsically disordered N-terminal IDR of LARP6 restricts conformational flexibility of the adjacent La-module and forms auxiliary contacts with RNA, thereby narrowing RNA-binding selectivity. Deletion of the N-terminal IDR broadens LARP6 RNA footprints (iCLIP). This IDR-mediated selectivity is required for LARP6-driven cancer cell viability and invasion, as shown by mutagenesis and cellular functional assays. Mass spectrometry-based RNA interaction mapping in living cells, iCLIP, mutagenesis, cancer cell invasion/viability assays Nature communications High 41714637
2026 LARP6 is upregulated in activated hepatic stellate cells (HSCs) in MASH/MetALD by JUNB transcriptional activation. eCLIP-ribosome profiling integration shows LARP6 interacts with >300 mature mRNAs including structural elements in COL1A1, COL1A2, and COL3A1 to regulate their translation. IP-mass spectrometry identified LARP6 protein-protein interactions with mRNA translation components and the actin cytoskeleton. eCLIP, ribosome profiling, IP-mass spectrometry, snRNA-seq, ATAC-seq, HSC-specific siRNA knockdown The Journal of clinical investigation High 41746718
2025 Solution NMR structure of the La domain of human LARP6 in the RNA-bound state reveals a non-canonical binding interface integrating electrostatic and hydrophobic contacts with shape complementarity for 5'SL recognition. Chemical shift perturbation, solvent paramagnetic relaxation enhancement, intermolecular NOEs, and targeted mutagenesis identify this interface; the La domain alone discriminates 5'SL from homopolymeric or purely helical hairpin RNAs with low-nanomolar affinity, overturning the view that the RRM is required for recognition. Solution NMR structure determination, chemical shift perturbation, solvent PRE, intermolecular NOEs, mutagenesis, RNA binding assays bioRxivpreprint Medium bio_10.1101_2025.05.22.652967
2023 LARP6 binds ZNF267 mRNA and regulates its stability and translation in colorectal cancer cells. Reduced ZNF267 by LARP6 inhibits downstream SGMS2 expression, causing ceramide/sphingomyelin imbalance and enhanced autophagy, thereby suppressing CRC progression. RIP-seq, RIP-qPCR, stable overexpression/knockdown, mRNA stability assay, autophagy assay Journal of experimental & clinical cancer research Medium 36691044
2025 In MDA-MB-231 triple-negative breast cancer cells, LARP6 directly binds mRNAs (iRIP-seq identifies CGACGAG binding motif) and regulates alternative splicing of >1000 events, with regulated genes enriched in DNA repair and cell cycle pathways, promoting cancer cell proliferation and invasion. iRIP-seq, RNA-seq, RT-qPCR, RIP-qPCR Scientific reports Medium 40050364

Source papers

Stage 0 corpus · 37 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen. Journal of molecular biology 91 19917293
2014 Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA. The Journal of biological chemistry 83 24469459
2016 LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression. International journal of molecular sciences 77 27011170
2014 Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module. Nucleic acids research 55 25488812
2019 Discovery and evaluation of inhibitor of LARP6 as specific antifibrotic compound. Scientific reports 38 30674965
2014 Characterization of binding of LARP6 to the 5' stem-loop of collagen mRNAs: implications for synthesis of type I collagen. RNA biology 36 25692237
2007 Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta. Gene 34 17383118
2016 Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen. Scientific reports 31 26932461
2021 ER-anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6. The EMBO journal 28 34223653
2017 Insulin-like growth factor-1 promotes osteogenic differentiation and collagen I alpha 2 synthesis via induction of mRNA-binding protein LARP6 expression. Development, growth & differentiation 28 28211947
2014 Role of LARP6 and nonmuscle myosin in partitioning of collagen mRNAs to the ER membrane. PloS one 26 25271881
2011 The novel lupus antigen related protein acheron enhances the development of human breast cancer. International journal of cancer 24 21387291
2013 Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis. PloS one 23 23755290
2023 LARP6 suppresses colorectal cancer progression through ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis. Journal of experimental & clinical cancer research : CR 21 36691044
2017 mTORC1 phosphorylates LARP6 to stimulate type I collagen expression. Scientific reports 21 28112218
2020 Maternal Larp6 controls oocyte development, chorion formation and elevation. Development (Cambridge, England) 17 32054660
2009 Regulation of muscle differentiation and survival by Acheron. Mechanisms of development 17 19481601
2022 LARP6 Regulates Keloid Fibroblast Proliferation, Invasion, and Ability to Synthesize Collagen. The Journal of investigative dermatology 15 35176288
2009 Acheron, a Lupus antigen family member, regulates integrin expression, adhesion, and motility in differentiating myoblasts. American journal of physiology. Cell physiology 15 19889961
2020 Acheron/Larp6 Is a Survival Protein That Protects Skeletal Muscle From Programmed Cell Death During Development. Frontiers in cell and developmental biology 10 32850788
2011 Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing. Cell biochemistry and function 10 22139627
2021 Characterization of Sequence-Specific Binding of LARP6 to the 5' Stem-Loop of Type I Collagen mRNAs and Implications for Rational Design of Antifibrotic Drugs. Journal of molecular biology 9 34896113
2017 Recombinant expression and purification of the RNA-binding LARP6 proteins from fish genetic model organisms. Protein expression and purification 6 28400296
2015 (1)H, (15)N and (13)C chemical shift assignments of the La motif and RRM1 from human LARP6. Biomolecular NMR assignments 5 25896032
2025 A Robust Expression and Purification Protocol for the Production of the La Domain of Human LARP6. ACS omega 4 40191362
2011 [Regulation of proliferation and apoptosis of human vascular endothelial cell by Acheron]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 4 21651853
2025 Cardiomyocyte-specific LARP6 overexpression prevents angiotensin II-induced myocardial dysfunction and interstitial fibrosis. American journal of physiology. Heart and circulatory physiology 3 40824882
2021 LARP6 proteins in plants. Biochemical Society transactions 3 34709399
2019 Technology for Discovery of Antifibrotic Drugs: Phenotypic Screening for LARP6 Inhibitors Using Inverted Yeast Three Hybrid System. Assay and drug development technologies 3 30901265
2024 The binding of LARP6 and DNAAF6 in biomolecular condensates influences ciliogenesis of multiciliated cells. The Journal of biological chemistry 2 38762183
2025 LARP6 regulates the mRNA translation of fibrogenic genes in liver fibrosis. bioRxiv : the preprint server for biology 1 39868246
2025 The RNA-binding protein LARP6 regulates the alternative splicing of related genes in MDA-MB-231 cells. Scientific reports 1 40050364
2025 The LARP6 La module from Tetrabaena socialis reveals structural and functional differences from plant and animal LARP6 homologues. RNA biology 1 40181506
2026 An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6. Nature communications 0 41714637
2026 RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis. The Journal of clinical investigation 0 41746718
2025 A Robust Expression and Purification Protocol for the Production of the La Domain of Human LARP6. bioRxiv : the preprint server for biology 0 38915490
2025 IGF-1 regulates LARP6-mediated collagen metabolism in vaginal fibroblasts of POP patients via the PI3K/AKT pathway. Scientific reports 0 40593278