Affinage

LARP6

La-related protein 6 · UniProt Q9BRS8

Length
491 aa
Mass
54.7 kDa
Annotated
2026-06-10
37 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LARP6 is a sequence-specific RNA-binding protein that licenses the coordinated translation of fibrillar collagen mRNAs and, more broadly, sculpts the translation and splicing of hundreds of transcripts (PMID:19917293, PMID:41746718). It recognizes a conserved 5' stem-loop (5'SL) in the 5'UTR of type I and III collagen mRNAs (COL1A1, COL1A2, COL3A1) with low-nanomolar affinity through a bipartite La-module; the La domain is necessary and sufficient for 5'SL recognition via a three-residue RNK motif in a flexible loop, while the RRM stabilizes the complex, with interdomain dynamics and an N-terminal intrinsically disordered region restricting conformational flexibility to narrow binding selectivity [PMID:19917293, PMID:25488812, PMID:34896113, PMID:41714637, PMID:bio_10.1101_2025.05.22.652967]. Through a SEC61-contacting loop in its RRM, LARP6 directs collagen mRNAs to the ER membrane, where together with nonmuscle myosin filaments it partitions them for focal, coordinated translation; disrupting this targeting causes hypermodification, poor secretion, and cytosolic accumulation of collagen (PMID:25692237, PMID:25271881). LARP6 activity is governed by hierarchical phosphorylation: Akt phosphorylates S451 as a prerequisite for further modification, and mTORC1 phosphorylates S348/S409 to promote interaction with the accessory protein STRAP and release LARP6 from the ER, with phospho-deficient mutants acting dominant-negatively on collagen biosynthesis (PMID:26932461, PMID:28112218). Additional partners FKBP3, the ER-anchored CRTH2 (which routes collagen mRNA to degradation), and DNAAF6 (which co-condenses with LARP6 to support α-tubulin expression during ciliogenesis) modulate or extend these activities (PMID:23755290, PMID:34223653, PMID:38762183). Beyond collagen, LARP6 binds ZNF267 mRNA to perturb SGMS2-dependent sphingomyelin metabolism and autophagy in colorectal cancer, regulates >1000 alternative splicing events enriched in DNA repair and cell cycle genes, and its IDR-dependent RNA selectivity drives cancer cell viability and invasion (PMID:36691044, PMID:41714637, PMID:40050364). In development, LARP6 (Acheron) acts upstream of MyoD and integrin α7β1 during myogenesis and functions as a muscle survival factor in insects (PMID:19481601, PMID:19889961, PMID:32850788).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2009 High

    Established LARP6 as a sequence-specific regulator of collagen biosynthesis, answering whether a dedicated factor controls type I collagen mRNA translation.

    Evidence RNA binding/Kd measurement, gel shift, siRNA knockdown, polysome profiling and collagen-GFP reporter in cells

    PMID:19917293

    Open questions at the time
    • Structural basis of bipartite binding undefined
    • Mechanism coupling binding to focal ER synthesis not resolved
  2. 2009 Medium

    Independently identified LARP6 (Acheron) as a developmental regulator acting upstream of MyoD and integrin α7β1 in myogenesis, broadening its biological scope beyond collagen.

    Evidence C2C12 differentiation, dominant-negative/antisense, zebrafish morpholino, integrin expression and adhesion/migration assays

    PMID:19481601 PMID:19889961

    Open questions at the time
    • Molecular link between LARP6 RNA binding and MyoD regulation unknown
    • Direct target mRNAs in myogenesis not identified
  3. 2011 Medium

    Showed nuclear-localized Acheron/LARP6 promotes proliferation and invasion in breast cancer, implicating it in tumorigenesis.

    Evidence NLS/NES deletion mutants, proliferation/invasion assays, xenografts, MMP-9/VEGF Western blot

    PMID:21387291

    Open questions at the time
    • Nuclear molecular targets not defined
    • Relationship to cytoplasmic collagen-regulatory function unclear
  4. 2013 Medium

    Identified FKBP3 as a LARP6 partner required for collagen polypeptide translation, adding an accessory factor to the collagen translation machinery.

    Evidence Co-IP, FK506 perturbation, in vitro collagen synthesis assay

    PMID:23755290

    Open questions at the time
    • Mechanism of FKBP3 contribution to translation unresolved
    • Single lab, no reciprocal structural validation
  5. 2014 High

    Defined the structural and sequence determinants of 5'SL recognition and linked LARP6 to the SEC61 translocon, explaining how it couples mRNA binding to ER-targeted collagen synthesis.

    Evidence X-ray crystallography/NMR of La-module, mutagenesis, gel shift, Co-IP with SEC61, dominant-negative overexpression, ER fractionation with nonmuscle myosin perturbation

    PMID:25271881 PMID:25488812 PMID:25692237

    Open questions at the time
    • Atomic structure of the La-domain–5'SL complex still missing
    • How myosin filaments physically partition mRNAs unclear
  6. 2017 High

    Revealed hierarchical Akt and mTORC1 phosphorylation as the regulatory switch controlling LARP6 function and ER recycling via STRAP.

    Evidence MS phosphosite mapping, kinase inhibition, site-directed mutagenesis with dominant-negative readouts, Co-IP with STRAP, ER fractionation

    PMID:26932461 PMID:28112218

    Open questions at the time
    • Order and stoichiometry of all 8 phosphosites incomplete
    • STRAP's mechanistic role in coordinated translation undefined
  7. 2021 High

    Pinpointed the La-domain RNK motif as the necessary and sufficient determinant of 5'SL specificity and identified CRTH2 as an upstream negative regulator of collagen mRNA stability.

    Evidence Mutagenesis, UV crosslinking, domain deletion; reciprocal Co-IP, caveolin-1 KO, genetic epistasis with rescue

    PMID:34223653 PMID:34896113

    Open questions at the time
    • Structural detail of RNK–RNA contact not yet atomic
    • How CRTH2 routes bound mRNA to degradation unknown
  8. 2023 Medium

    Extended LARP6 targets beyond collagen to ZNF267 mRNA, linking it to sphingomyelin metabolism and autophagy in colorectal cancer.

    Evidence RIP-seq/RIP-qPCR, overexpression/knockdown, Western blot, autophagy assays

    PMID:36691044

    Open questions at the time
    • Direct vs indirect regulation of SGMS2 not separated
    • Whether 5'SL-like elements mediate ZNF267 binding unknown
  9. 2024 Medium

    Demonstrated that LARP6–DNAAF6 condensates drive α-tubulin mRNA expression for ciliogenesis, defining a distinct condensate-based function.

    Evidence Co-IP, live colocalization imaging, Xenopus morphant/rescue with binding-deficient DNAAF6 mutant

    PMID:38762183

    Open questions at the time
    • Whether condensate formation is required for translation control untested
    • Conservation in mammalian ciliogenesis not shown
  10. 2026 High

    Genome-wide profiling redefined LARP6 as a broad RNA regulator binding >300 mature mRNAs and over a thousand splicing events, with an IDR that narrows its RNA selectivity to support cancer phenotypes.

    Evidence eCLIP, ribosome profiling, IP-MS, iCLIP, iRIP-seq, mutagenesis, cancer cell viability/invasion and splicing assays

    PMID:40050364 PMID:41714637 PMID:41746718

    Open questions at the time
    • Functional consequence of most bound transcripts not validated
    • Coupling between IDR-restricted binding and specific splicing/translation outcomes incomplete
  11. 2025 High

    Solution structure and stability studies of the La domain–5'SL complex showed the La domain alone discriminates 5'SL with low-nanomolar affinity and is stabilized >50-fold upon binding.

    Evidence Solution NMR structure (preprint), CSP/PRE/NOEs, mutagenesis; limited proteolysis and stability assays with truncations

    PMID:40191362 PMID:bio_10.1101_2025.05.22.652967

    Open questions at the time
    • NMR structure awaits peer review
    • Role of full-length protein and RRM in vivo selectivity vs isolated La domain not reconciled

Open questions

Synthesis pass · forward-looking unresolved questions
  • How LARP6's discrete activities—ER-coupled collagen translation, condensate-based ciliogenesis, nuclear pro-tumorigenic signaling, and genome-wide splicing—are integrated under a single regulatory logic remains unresolved.
  • No unifying model linking phosphorylation state to target choice
  • Functional significance of most non-collagen targets unvalidated
  • Mammalian relevance of model-organism developmental roles untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 8 GO:0045182 translation regulator activity 3 GO:0060090 molecular adaptor activity 2
Localization
GO:0005783 endoplasmic reticulum 4 GO:0005829 cytosol 2 GO:0005634 nucleus 1
Pathway
R-HSA-392499 Metabolism of proteins 4 R-HSA-1266738 Developmental Biology 3 R-HSA-1474244 Extracellular matrix organization 3 R-HSA-8953854 Metabolism of RNA 2
Partners
BBH1CRTH2DNAAF6FKBP3SEC61STRAP
Complex memberships
dynein axonemal particle (LARP6–DNAAF6 condensate)

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2009 LARP6 binds the conserved 5' stem-loop (5'SL) in the 5'UTR of type I collagen mRNAs (COL1A1 and COL1A2) in a sequence-specific manner with Kd of 1.4 nM, using a bipartite RNA binding domain (La motif + RRM). LARP6 does not associate with polysomes; overexpression blocks ribosomal loading on collagen mRNAs, while knockdown also decreases polysomal loading. LARP6 activity is required for focal (discrete ER-localized) synthesis of collagen polypeptides. RNA binding assay (Kd measurement), gel mobility shift, siRNA knockdown, polysome profiling, collagen-GFP reporter in cells Journal of molecular biology High 19917293
2014 Structure of the La motif (LaM) and RRM1 of human LARP6 was solved, revealing considerable structural variation from the prototypic La protein. RNA recognition requires synergy between LaM, RRM1, and the interdomain linker. Mutagenesis guided by the structure showed that the interdomain linker and tandem domain dynamics are required for substrate selectivity toward the collagen 5'SL. X-ray crystallography, mutagenesis, NMR Nucleic acids research High 25488812
2014 Five specific nucleotides within the single-stranded regions of the 5'SL are required for high-affinity LARP6 binding; mutation of individual nucleotides abolishes binding. LARP6 requires both the La domain (T133 critical for folding) and the RRM (loop 3 critical for 5'SL binding). Loop 3 of the RRM also mediates interaction with the protein translocation channel SEC61, and a LARP6 mutant that binds 5'SL but cannot interact with SEC61 suppresses collagen synthesis in a dominant-negative manner. Gel mobility shift assay, mutagenesis, Co-IP (LARP6–SEC61 interaction), dominant-negative overexpression RNA biology High 25692237
2014 LARP6 associates with ER membranes and, together with nonmuscle myosin filaments, partitions collagen mRNAs to the ER membrane prior to signal peptide synthesis. Knockdown of LARP6 or depolymerization of nonmuscle myosin releases collagen mRNAs from the ER membrane and causes hypermodification, poor secretion, and cytosolic accumulation of collagen polypeptides, indicating loss of coordinated translation. ER membrane fractionation, siRNA knockdown, nonmuscle myosin depolymerization, Western blot, microscopy PloS one High 25271881
2013 FKBP3 (FKBP25) interacts with LARP6 and co-immunoprecipitates collagen mRNAs. FK506 (tacrolimus) weakens the FKBP3–LARP6 interaction, reducing pull-down of collagen mRNAs by FKBP3 and inhibiting translation of collagen α1(I) polypeptide without affecting collagen mRNA levels. Co-IP, Western blot, FK506 pharmacological treatment, in vitro collagen synthesis assay PloS one Medium 23755290
2016 LARP6 is phosphorylated at 8 serines in lung fibroblasts; phosphorylation follows a hierarchical order with S451 as a prerequisite for other phosphorylations. PI3K/Akt pathway (specifically Akt kinase) phosphorylates S451. S451A mutant has a dominant-negative effect on collagen biosynthesis, drastically reducing collagen secretion and inducing hypermodification of collagen α2(I) polypeptides. Mass spectrometry phosphosite mapping, PI3K/Akt inhibition, site-directed mutagenesis (S451A dominant negative), collagen secretion assay Scientific reports High 26932461
2017 mTORC1 phosphorylates LARP6 on S348 and S409. The S348A/S409A mutant acts as a dominant-negative in collagen biosynthesis, retarding secretion and causing excessive posttranslational modifications. S348A/S409A weakly interacts with accessory protein STRAP (needed for coordinated translation); mTORC1 inhibitor rapamycin or raptor knockdown attenuates this interaction. Loss of S348/S409 phosphorylation also sequesters LARP6 at the ER membrane. Site-directed mutagenesis, rapamycin treatment, raptor siRNA knockdown, Co-IP (LARP6–STRAP), collagen secretion assay, ER fractionation Scientific reports High 28112218
2021 The La domain of LARP6 is necessary and sufficient for sequence-specific recognition of the 5'SL RNA. A three-amino-acid RNK motif in the flexible loop connecting the second α-helix to the β-sheet of the La domain is critical for binding; mutation of any of these three residues abolishes binding. The RRM domain stabilizes the La domain–5'SL complex but does not make extensive contacts with 5'SL. The major UV crosslinking site of LARP6 to 5'SL RNA maps to this RNK motif. The RNK motif is absent in other LARPs, which cannot bind 5'SL. Mutagenesis, gel mobility shift, UV crosslinking, domain deletion analysis Journal of molecular biology High 34896113
2021 ER-anchored CRTH2 (trafficked to ER membrane in a caveolin-1-dependent manner) binds the collagen mRNA recognition motif of LARP6, promoting degradation of collagen mRNA in fibroblasts. CRTH2 deficiency increases collagen biosynthesis, and this effect is rescued by LARP6 depletion, placing CRTH2 upstream of LARP6 in collagen mRNA regulation. Co-IP (CRTH2–LARP6 interaction), caveolin-1 KO (trafficking), genetic epistasis (CRTH2 KO + LARP6 KD rescue), collagen mRNA stability assay The EMBO journal High 34223653
2023 LARP6 binds ZNF267 mRNA and regulates its stability and translation. This leads to inhibition of SGMS2 (a downstream target of ZNF267), causing ceramide/sphingomyelin imbalance in colorectal cancer cells. LARP6 also enhances autophagy activity in CRC cells, at least partially through inhibition of SGMS2-mediated sphingomyelin synthesis. RIP-seq, RIP-qPCR, LARP6 overexpression/knockdown, Western blot, autophagy assays Journal of experimental & clinical cancer research Medium 36691044
2024 In Xenopus multiciliated cells, LARP6 and DNAAF6 colocalize in biomolecular condensates (dynein axonemal particles). LARP6 binds tubulin alpha 1c-like mRNA encoding α-tubulin (a major component of ciliary axoneme). DNAAF6 is required for high α-tubulin protein expression near the apical side during ciliogenesis, and a DNAAF6 mutant that cannot bind LARP6 fails to restore apical α-tubulin expression, demonstrating that the LARP6–DNAAF6 interaction is required for ciliogenesis. Co-IP (LARP6–DNAAF6), live imaging/colocalization in condensates, Xenopus morphant/rescue experiments, mutagenesis of DNAAF6 binding interface The Journal of biological chemistry Medium 38762183
2026 eCLIP and ribosome profiling in human hepatic stellate cells showed that LARP6 interacts with mature mRNAs of >300 genes, binding RNA structural elements within COL1A1, COL1A2, and COL3A1 to regulate mRNA expression and translation. IP-mass spectrometry identified LARP6 protein-protein interactions with mRNA translation components and the actin cytoskeleton. JUNB transcription factor upregulates LARP6 expression in activated HSCs. eCLIP, ribosome profiling, IP-mass spectrometry, snRNA-seq, ATAC-seq, siRNA knockdown The Journal of clinical investigation High 41746718
2026 The N-terminal intrinsically disordered region (IDR) of LARP6 restricts the conformational flexibility of the adjacent La-module and forms auxiliary contacts with RNA, thereby narrowing LARP6 RNA-binding selectivity. Deletion of the N-terminal IDR broadens LARP6 RNA footprints (detected by iCLIP). IDR-mediated RNA-binding selectivity is critical for LARP6-driven cancer cell viability and invasion. The La-module (not IDRs) is essential for RNA binding per se. Mass spectrometry-based RNA interaction mapping in living cells, iCLIP, mutagenesis/deletion analysis, cancer cell viability and invasion assays Nature communications High 41714637
2009 Acheron/LARP6 acts upstream of the muscle-specific transcription factor MyoD in C2C12 myoblasts. Forced expression of ectopic Acheron results in larger myotubes and reserve cell death; dominant-negative or antisense Acheron blocks myotube formation. In zebrafish, antisense morpholino reduction of Acheron leads to muscle fiber loss, while ectopic Acheron enhances muscle fiber formation. C2C12 myoblast differentiation assay, ectopic expression, dominant-negative expression, antisense knockdown, zebrafish morpholino Mechanisms of development Medium 19481601
2009 Acheron/LARP6 controls expression of the laminin receptor integrin α7β1 during myoblast differentiation; loss of Acheron (via antisense or deletion mutant) blocks laminin receptor expression and reduces substrate adhesion and migration on laminin but not fibronectin, linking Acheron to integrin-mediated extracellular matrix interactions during myogenesis. Ectopic expression, antisense/dominant-negative deletion mutant, integrin expression (Western blot/flow cytometry), adhesion and migration assays American journal of physiology. Cell physiology Medium 19889961
2011 In human breast cancer MDA-MB-231 cells, Acheron/LARP6 enhances cell proliferation, lamellipodia formation, invasive activity, and drives elevated expression of MMP-9 and VEGF. Nuclear localization is required: AchnNLS (lacking NLS) did not enhance these activities, while AchnNES (lacking NES, thus retained in nucleus) did, indicating that nuclear localization is necessary for Acheron's pro-tumorigenic activity. Stable expression of GFP-tagged Acheron variants (WT, ΔNLS, ΔNES), proliferation assay, invasion assay, in vivo xenograft (SCID/Beige mice), Western blot for MMP-9/VEGF International journal of cancer Medium 21387291
2020 In Manduca sexta ISMs, Acheron/LARP6 functions as a survival protein protecting muscles until eclosion; at eclosion it becomes phosphorylated and degraded in response to Eclosion Hormone (EH). Acheron binds a novel BH3-only protein BBH1 (BAD/BNIP3 homology 1); BBH1 accumulates when muscles commit to die and is presumably liberated upon Acheron degradation, correlated with cytochrome c release and cell death. RNAi in Drosophila confirmed loss of Acheron causes precocious muscle death. Co-IP (Acheron–BBH1), phosphorylation assay (EH-stimulated), RNAi in Drosophila, cytochrome c release assay Frontiers in cell and developmental biology Medium 32850788
2025 De novo solution NMR structure of the La domain of human LARP6 in complex with 5'SL RNA reveals a non-canonical binding interface integrating electrostatic and hydrophobic contacts with shape complementarity. Chemical shift perturbation, solvent paramagnetic relaxation enhancement, intermolecular NOEs, and targeted mutagenesis converge on this interface. The La domain alone discriminates 5'SL from homopolymeric or purely helical hairpin RNAs with low-nanomolar affinity, overturning the view that the RRM is required for recognition. Solution NMR structure determination, chemical shift perturbation, paramagnetic relaxation enhancement, intermolecular NOEs, mutagenesis, RNA binding affinity measurements bioRxivpreprint High bio_10.1101_2025.05.22.652967
2025 The La domain of LARP6 is stabilized >50-fold when in complex with its cognate 5'SL RNA compared to the unbound (aggregation-prone) state. C-terminal truncations greatly impair protein stability while N-terminal truncations have little effect on aggregation or RNA binding. Recombinant protein expression, limited proteolysis, stability assays, RNA binding assays ACS omega Medium 40191362
2025 LARP6 regulates alternative splicing of >1000 events in MDA-MB-231 TNBC cells and tends to bind the CGACGAG motif. iRIP-seq identified 16 genes where LARP6 directly binds and regulates alternative splicing, with enrichment in DNA repair and cell cycle pathways. RNA-seq, iRIP-seq, RT-qPCR, RIP-qPCR Scientific reports Medium 40050364

Source papers

Stage 0 corpus · 37 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen. Journal of molecular biology 92 19917293
2014 Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA. The Journal of biological chemistry 84 24469459
2016 LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression. International journal of molecular sciences 77 27011170
2014 Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module. Nucleic acids research 56 25488812
2019 Discovery and evaluation of inhibitor of LARP6 as specific antifibrotic compound. Scientific reports 40 30674965
2014 Characterization of binding of LARP6 to the 5' stem-loop of collagen mRNAs: implications for synthesis of type I collagen. RNA biology 37 25692237
2007 Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta. Gene 34 17383118
2016 Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen. Scientific reports 31 26932461
2021 ER-anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6. The EMBO journal 30 34223653
2017 Insulin-like growth factor-1 promotes osteogenic differentiation and collagen I alpha 2 synthesis via induction of mRNA-binding protein LARP6 expression. Development, growth & differentiation 29 28211947
2014 Role of LARP6 and nonmuscle myosin in partitioning of collagen mRNAs to the ER membrane. PloS one 27 25271881
2011 The novel lupus antigen related protein acheron enhances the development of human breast cancer. International journal of cancer 24 21387291
2013 Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis. PloS one 23 23755290
2023 LARP6 suppresses colorectal cancer progression through ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis. Journal of experimental & clinical cancer research : CR 21 36691044
2017 mTORC1 phosphorylates LARP6 to stimulate type I collagen expression. Scientific reports 21 28112218
2020 Maternal Larp6 controls oocyte development, chorion formation and elevation. Development (Cambridge, England) 17 32054660
2009 Regulation of muscle differentiation and survival by Acheron. Mechanisms of development 17 19481601
2022 LARP6 Regulates Keloid Fibroblast Proliferation, Invasion, and Ability to Synthesize Collagen. The Journal of investigative dermatology 16 35176288
2009 Acheron, a Lupus antigen family member, regulates integrin expression, adhesion, and motility in differentiating myoblasts. American journal of physiology. Cell physiology 15 19889961
2020 Acheron/Larp6 Is a Survival Protein That Protects Skeletal Muscle From Programmed Cell Death During Development. Frontiers in cell and developmental biology 10 32850788
2011 Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing. Cell biochemistry and function 10 22139627
2021 Characterization of Sequence-Specific Binding of LARP6 to the 5' Stem-Loop of Type I Collagen mRNAs and Implications for Rational Design of Antifibrotic Drugs. Journal of molecular biology 9 34896113
2017 Recombinant expression and purification of the RNA-binding LARP6 proteins from fish genetic model organisms. Protein expression and purification 6 28400296
2015 (1)H, (15)N and (13)C chemical shift assignments of the La motif and RRM1 from human LARP6. Biomolecular NMR assignments 5 25896032
2025 A Robust Expression and Purification Protocol for the Production of the La Domain of Human LARP6. ACS omega 4 40191362
2025 Cardiomyocyte-specific LARP6 overexpression prevents angiotensin II-induced myocardial dysfunction and interstitial fibrosis. American journal of physiology. Heart and circulatory physiology 4 40824882
2011 [Regulation of proliferation and apoptosis of human vascular endothelial cell by Acheron]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 4 21651853
2021 LARP6 proteins in plants. Biochemical Society transactions 3 34709399
2019 Technology for Discovery of Antifibrotic Drugs: Phenotypic Screening for LARP6 Inhibitors Using Inverted Yeast Three Hybrid System. Assay and drug development technologies 3 30901265
2024 The binding of LARP6 and DNAAF6 in biomolecular condensates influences ciliogenesis of multiciliated cells. The Journal of biological chemistry 2 38762183
2026 RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis. The Journal of clinical investigation 1 41746718
2025 LARP6 regulates the mRNA translation of fibrogenic genes in liver fibrosis. bioRxiv : the preprint server for biology 1 39868246
2025 The RNA-binding protein LARP6 regulates the alternative splicing of related genes in MDA-MB-231 cells. Scientific reports 1 40050364
2025 The LARP6 La module from Tetrabaena socialis reveals structural and functional differences from plant and animal LARP6 homologues. RNA biology 1 40181506
2026 An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6. Nature communications 0 41714637
2025 A Robust Expression and Purification Protocol for the Production of the La Domain of Human LARP6. bioRxiv : the preprint server for biology 0 38915490
2025 IGF-1 regulates LARP6-mediated collagen metabolism in vaginal fibroblasts of POP patients via the PI3K/AKT pathway. Scientific reports 0 40593278

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