Affinage

LAMC1

Laminin subunit gamma-1 · UniProt P11047

Length
1609 aa
Mass
177.6 kDa
Annotated
2026-06-10
40 papers in source corpus 18 papers cited in narrative 19 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 4/5 claims corpus-supported (80%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LAMC1 encodes the laminin gamma1 subunit, an indispensable structural component of basement membranes that nucleates laminin heterotrimer assembly and organizes the broader extracellular matrix. In the absence of gamma1, secreted laminin and nidogen fail to incorporate into the ECM and collagen IV and perlecan remain disorganized, abolishing basement membrane formation; this defect is dispensable for the first (trophectodermal) epithelium but becomes essential for extra-embryonic endoderm differentiation, causing early embryonic lethality in LAMC1-null mice (PMID:9885251, PMID:9917858). A direct physical interaction between gamma1 and nidogen-1 (NID1) underlies its matrix-organizing role, and disruption of this contact is genetically linked to cerebellar developmental malformation (PMID:23674478). LAMC1 transcription is driven by Sp1 acting on GC-rich promoter elements (PMID:9403717), and its expression is further tuned in disease and developmental contexts by allele-specific binding of additional transcription factors to regulatory variants (PMID:35031421). Post-transcriptionally, LAMC1 is repressed by multiple 3'UTR-targeting miRNAs (miR-29a/b/c, miR-124, miR-506); alternative polyadenylation under NUDT21 control shortens the 3'UTR to remove these miRNA sites and elevate LAMC1 protein (PMID:24820027, PMID:37389756), while the LAMC1 transcript itself can act as a competing endogenous RNA sequestering miR-124 (PMID:28524360). Beyond its structural function, LAMC1 acts as a signaling ligand: it drives cell survival through FAK/PI3K/AKT signaling (PMID:38609046), promotes migration and Warburg metabolism via AKT-dependent PKM2 induction and AKT-NFκB-MMP9/14 activation in cancer (PMID:30755064, PMID:34218518), and preserves blood-brain barrier integrity by protecting the tight junction proteins ZO-1 and occludin from degradation (PMID:41534552).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1999 High

    Established that gamma1 is the obligate organizing subunit of basement membranes, answering whether a single laminin chain is required to polymerize laminin and assemble the entire ECM scaffold.

    Evidence Homologous-recombination knockout in mouse ES cells with embryoid body culture, ECM fractionation, and immunofluorescence

    PMID:9885251

    Open questions at the time
    • Does not resolve the domain-level mechanism of gamma1-driven laminin polymerization
    • Does not address gamma1 function in adult tissue homeostasis
  2. 1999 High

    Placed LAMC1-dependent basement membranes epistatically in development, showing they are dispensable for the first epithelium but essential for extra-embryonic endoderm differentiation.

    Evidence LAMC1 knockout mouse with staged histological analysis of embryos

    PMID:9885251 PMID:9917858

    Open questions at the time
    • Does not identify the cellular signal by which basement membrane loss blocks endoderm differentiation
  3. 1997 High

    Identified Sp1 as a direct transcriptional activator of LAMC1, answering how the gene's expression is driven at the promoter level.

    Evidence EMSA, DNase I hypersensitivity mapping, Sp1 overexpression in hepatocytes, and reconstitution reporter assays in Sp1-null SL2 cells

    PMID:9403717

    Open questions at the time
    • Does not define which signals modulate Sp1 occupancy at the LAMC1 promoter in vivo
    • An unidentified ~60 kDa CTC-binding factor remained uncharacterized
  4. 2013 Medium

    Linked the gamma1-nidogen-1 interaction to human disease, showing a LAMC1 missense mutation that disrupts the NID1-LAMC1 complex underlies cerebellar malformation.

    Evidence Whole-exome sequencing, interaction network analysis, and structural modeling of the NID1-LAMC1 complex in independent families

    PMID:23674478

    Open questions at the time
    • Disrupted interaction not validated biochemically in vitro
    • Tissue-specific consequence of complex disruption not directly tested
  5. 2015 Medium

    Defined a layered miRNA control circuit over LAMC1, showing androgen-receptor-suppressed miR-22/miR-29a directly target the 3'UTR to regulate prostate cancer invasion.

    Evidence Luciferase 3'UTR reporters, siRNA knockdown, ChIP-seq for AR, and Transwell assays

    PMID:24820027 PMID:26052614

    Open questions at the time
    • Single-lab functional data
    • Relative contribution of each miRNA to endogenous LAMC1 levels not quantified
  6. 2017 Medium

    Showed LAMC1 mRNA functions as a competing endogenous RNA, sequestering miR-124 to de-repress CD151 and promote HCC migration.

    Evidence Dual 3'UTR luciferase reporter, miR-124 gain/loss, Western blot, and clinical tissue correlation

    PMID:28524360

    Open questions at the time
    • ceRNA stoichiometry under physiological miRNA abundance not established
    • Single lab
  7. 2023 Medium

    Connected 3'UTR processing to LAMC1 dosage, showing NUDT21-controlled alternative polyadenylation shortens the 3'UTR to remove miR-124/506 sites and elevate LAMC1-driven glioma migration.

    Evidence PAC-seq, qRT-PCR, Western blot, and siRNA co-depletion rescue with Transwell assays

    PMID:37389756

    Open questions at the time
    • Generality of APA control across other LAMC1-expressing tissues untested
    • Single lab
  8. 2019 Medium

    Identified a metabolic output of LAMC1 signaling, showing it promotes the Warburg effect by inducing PKM2 through the PTEN/PI3K/AKT axis.

    Evidence siRNA knockdown, PI3K inhibitor epistasis (LY294002), PKM2 rescue, glucose/lactate measurement, and Western blot in HCC cells

    PMID:30755064

    Open questions at the time
    • Whether the effect requires secreted LAMC1 or an intracellular pool unresolved
    • Receptor coupling LAMC1 to PTEN/AKT not identified
  9. 2021 Medium

    Mapped a TGFβ1-induced LAMC1 pro-tumor program, showing SMAD4/SP1 drive LAMC1 to activate AKT-NFκB-MMP9/14 and CXCL1-mediated fibroblast reprogramming.

    Evidence RNA microarray, ChIP for SMAD4/SP1, knockdown/overexpression, ELISA, and co-culture in esophageal squamous carcinoma

    PMID:34218518

    Open questions at the time
    • Direct receptor for LAMC1 in tumor and fibroblast compartments not defined
    • Single lab
  10. 2022 Medium

    Revealed a secreted, niche-forming role for LAMC1, showing autocrine LAMC1 drives preadipocyte differentiation and free-fatty-acid release within a STAT3/miR-193a-3p feedforward loop promoting peritoneal metastasis.

    Evidence Co-culture, luciferase reporter, RIP, ChIP, single-molecule magnetic tweezers, and single-cell sequencing in gastric cancer

    PMID:35541892

    Open questions at the time
    • Mechanism by which secreted LAMC1 engages preadipocytes not defined
    • Single lab
  11. 2024 Medium

    Demonstrated cytoprotective LAMC1 signaling in CNS injury, showing recombinant LAMC1 suppresses neuronal apoptosis via FAK/PI3K/AKT and preserves the blood-brain barrier by protecting ZO-1 and occludin.

    Evidence Rat SAH and mouse ICH models with rLAMC1/AAV gain-of-function, siRNA loss-of-function, FAK/PI3K inhibitor epistasis, and neurobehavioral testing

    PMID:38609046 PMID:41534552

    Open questions at the time
    • Receptor mediating LAMC1 neuroprotection not identified
    • Mechanism of tight-junction protein protection (degradation pathway) not resolved
  12. 2025 Medium

    Quantified context-dependent matrix dynamics, showing endogenous Lamc1 is stable in fin fold but more mobile in myoseptal basement membranes in vivo.

    Evidence CRISPR knock-in fluorescent tagging and FRAP in developing zebrafish (preprint)

    Open questions at the time
    • Preprint, single lab
    • Molecular basis of differential turnover between tissues not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • The cell-surface receptor(s) that transduce LAMC1's pro-survival, migratory, and metabolic signals remain unidentified, leaving the link between extracellular LAMC1 and the FAK/PI3K/AKT and NFκB cascades mechanistically incomplete.
  • No direct LAMC1 receptor characterized in the corpus
  • Whether structural and signaling functions use the same molecular pool is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0003723 RNA binding 1
Localization
GO:0005576 extracellular region 2 GO:0031012 extracellular matrix 2
Pathway
R-HSA-1266738 Developmental Biology 2 R-HSA-1474244 Extracellular matrix organization 2 R-HSA-162582 Signal Transduction 2
Partners
NID1
Complex memberships
basement membranelaminin heterotrimer

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 Laminin gamma1 (LAMC1) is required for laminin trimer assembly; knockout of LAMC1 in mouse embryonic stem cells results in absence of basement membranes, disorganized extracellular deposits of collagen IV and perlecan, and failure of nidogen deposition. Secreted nidogen and truncated laminin alpha1 were not incorporated into ECM without gamma1, demonstrating that gamma1 is essential for polymerizing laminin and for organizing other basement membrane components. Homologous recombination knockout in mouse ES cells; embryoid body culture; immunofluorescence/ECM fractionation The Journal of cell biology High 9885251
1999 Basement membranes are not required for formation of the first epithelium (trophectodermal) during embryogenesis, but LAMC1-dependent basement membranes become essential for extra-embryonic endoderm differentiation (parietal yolk sac formation); homozygous LAMC1-null embryos die at E5.5 due to failure of primitive endoderm to differentiate into visceral and parietal endoderm. LAMC1 knockout mouse; histological analysis of embryos at multiple developmental timepoints The Journal of cell biology High 9885251 9917858
1997 Transcription factor Sp1 directly transactivates the LAMC1 promoter via GC-rich elements; Sp1 overexpression in normal hepatocytes increases laminin-gamma1 mRNA, and co-transfection of LAMC1 promoter fragments with Sp1 in Drosophila SL2 cells (which lack endogenous Sp1) confirmed direct Sp1-mediated activation. Gel-shift (EMSA), DNase I hypersensitivity mapping, Sp1 overexpression, co-transfection/reporter assay in SL2 cells, in situ hybridization The American journal of pathology High 9403717
1996 Regulatory elements for LAMC1 expression in hepatocytes reside between -594 bp and -94 bp of the murine promoter, containing GC- and CTC-motifs; a ~60 kDa polypeptide binds the CTC-rich sequence and is implicated in transcriptional activation; the pattern of nuclear factor binding differs between freshly isolated hepatocytes and cultured hepatocytes/hepatoma cells, corresponding to LAMC1 transcriptional status. Transfection of deletion mutants, gel-shift assay, Southwestern analysis, affinity chromatography, actinomycin D/cycloheximide treatment The Biochemical journal Medium 8611150
2013 A missense mutation in LAMC1 (encoding a NID1-binding partner) disrupts the NID1-LAMC1 protein interaction as shown by structural modeling of the complex; this interaction is required for normal cerebellar development, and its loss is associated with autosomal dominant Dandy-Walker malformation and occipital cephaloceles. Whole-exome sequencing, protein interaction network analysis, structural modeling of NID1-LAMC1 complex Human mutation Medium 23674478
2014 miR-29s (miR-29a/b/c) directly target the 3'UTR of LAMC1 as shown by luciferase reporter assays; silencing LAMC1 inhibits prostate cancer cell migration and invasion, placing LAMC1 downstream of miR-29s in the focal adhesion pathway. Luciferase reporter assay, siRNA knockdown, Transwell migration/invasion assay International journal of oncology Medium 24820027
2015 Androgen receptor (AR) directly binds the genomic loci of miR-22 and miR-29a (ChIP-seq), which in turn target LAMC1 (luciferase reporter), establishing an AR→miR-22/miR-29a→LAMC1 regulatory axis in prostate cancer; AR activity suppresses miR-22/29a, thereby disinhibiting LAMC1. ChIP-seq, microarray expression profiling, luciferase reporter assay, miRNA mimic transfection Molecular endocrinology Medium 26052614
2019 LAMC1 promotes the Warburg effect in hepatocellular carcinoma cells by upregulating PKM2 expression through the PTEN/PI3K/AKT pathway; LAMC1 knockdown decreased glucose consumption, lactate production, GLUT1, and LDHA expression alongside increased PTEN and decreased AKT phosphorylation, and these effects were rescued by PKM2 overexpression or blocked by PI3K inhibition. siRNA knockdown, PI3K inhibitor (LY294002), Western blot, glucose/lactate measurement, cell viability assay Cancer biology & therapy Medium 30755064
2021 TGFβ1 upregulates LAMC1 in esophageal squamous cell carcinoma cells via synergistic activation by SMAD4 and SP1; LAMC1 then promotes tumor cell proliferation and migration via AKT-NFκB-MMP9/14 signaling and stimulates CXCL1 secretion, which induces formation of inflammatory cancer-associated fibroblasts (iCAF) through CXCR2-pSTAT3 signaling. RNA microarray, ChIP, siRNA/overexpression, Transwell migration, ELISA, co-culture experiments Molecular oncology Medium 34218518
2017 LAMC1 mRNA acts as a competing endogenous RNA (ceRNA) by sequestering miR-124 through two binding sites in its 3'UTR, thereby relieving miR-124-mediated repression of CD151 and promoting HCC cell migration and invasion in a miR-124-dependent manner. Luciferase reporter (3'UTR), miR-124 overexpression/inhibition, Western blot, Transwell migration/invasion assay, clinical tissue correlation IUBMB life Medium 28524360
2023 NUDT21 knockdown causes 3'UTR shortening of LAMC1 via preferential usage of a proximal polyadenylation signal, removing miR-124/506 binding sites, thereby relieving miRNA repression and increasing LAMC1 protein levels; this LAMC1 upregulation drives glioma cell migration, as co-depletion of LAMC1 with NUDT21 abolishes the migratory phenotype. PAC-seq, qRT-PCR, Western blot, siRNA co-depletion, Transwell migration assay Journal of neuro-oncology Medium 37389756
2024 Exogenous recombinant LAMC1 (rLAMC1) attenuates neuronal apoptosis after subarachnoid hemorrhage by activating the FAK/PI3K/AKT pathway, increasing Bcl-XL and Bcl-2 and decreasing Bax and cleaved caspase-3; the protective effects were abolished by FAK inhibitor Y15 and PI3K inhibitor LY294002, and LAMC1 knockdown worsened neurological outcomes. Rat SAH model, intranasal rLAMC1 administration, siRNA knockdown, pharmacological inhibitors (Y15, LY294002), Western blot, TUNEL staining, immunofluorescence, behavioral testing Experimental neurology Medium 38609046
2022 LAMC1 secreted by gastric cancer cells in an autocrine manner promotes preadipocyte differentiation and rupture, releasing free fatty acids into the peritoneal microenvironment to form pre-metastatic niches; differentiated adipocyte-derived palmitic acid activates STAT3, which inhibits miR-193a-3p, and miR-193a-3p in turn post-translationally regulates LAMC1, forming a feedforward loop promoting peritoneal metastasis. Co-culture model, luciferase reporter, RNA immunoprecipitation (RIP), ChIP, single-molecular magnetic tweezers, immunohistochemistry, single-cell sequencing International journal of biological sciences Medium 35541892
2024 LAMC1 overexpression in astrocytes/endothelial cells preserves blood-brain barrier integrity after intracerebral hemorrhage by inhibiting degradation of tight junction proteins ZO-1 and occludin; AAV-mediated LAMC1 overexpression in vivo reduced brain edema and improved neuromotor function. Mouse ICH model, AAV-mediated overexpression, Evans Blue extravasation, brain edema measurement, Western blot, neurobehavioral testing, multi-omics (TWAS/PWAS) + single-cell eQTL for gene identification Journal of advanced research Medium 41534552
2006 A SNP (rs10911193) in the LAMC1 promoter disrupts a binding site for transcription factor NFIL3, which is co-expressed with LAMC1 in vaginal tissue; the rare T variant segregates with early-onset pelvic organ prolapse in a three-generation family, suggesting NFIL3-mediated regulation of LAMC1 expression is relevant to connective tissue integrity. Genome-wide linkage scan, SNP sequencing, RT-PCR for co-expression, transcription factor binding site analysis Human genetics Low 17021862
2022 The LAMC1 intronic SNP rs3768617 shows allele-specific binding of transcription factor GFI1B to the risk allele 'G' but not the protective allele 'A', validated by EMSA and ChIP assay; GFI1B expression is reduced ~0.63-fold in Fuchs endothelial corneal dystrophy (FECD)-affected corneal endothelium, linking GFI1B-dependent LAMC1 regulation to FECD pathogenesis. EMSA, ChIP assay, luciferase reporter assay, immunofluorescence, genetic association study Gene Medium 35031421
2024 LAMC1 promotes osteogenic differentiation and inhibits adipogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs); Lamc1 knockdown inhibited both adipogenic and osteogenic differentiation, and cell communication analysis identified two receptors interacting with LAMC1 in this context. Single-cell RNA-seq analysis, qPCR validation, siRNA knockdown, transcriptomic dataset analysis Scientific reports Low 39179716
2024 LAMC1 knockdown decreased platelet-endothelium interaction in hyperglycemic HUVECs and did not potentiate the effects of PDI inhibitors, placing LAMC1 downstream of endothelial pecPDI in a pathway regulating platelet adhesion; LAMC1 was identified as one of 8 proteins secreted in a PDI-dependent manner by hyperglycemic endothelial cells. Secretomics (proteomics), siRNA knockdown, immunofluorescence, transendothelial electrical resistance, atomic force microscopy, Amplex Red H2O2 assay Journal of thrombosis and haemostasis Low 39128656
2025 LAMC1 is a stable ECM component in fin fold matrix but more dynamic (higher FRAP recovery) in myoseptal matrix of developing zebrafish, demonstrating tissue context-dependent stability of LAMC1 within basement membranes in vivo. CRISPR knock-in fluorescent tagging of endogenous Lamc1, live imaging, FRAP analysis in zebrafish bioRxivpreprint Medium

Source papers

Stage 0 corpus · 40 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1999 Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation. The Journal of cell biology 433 9885251
2014 Tumor-suppressive microRNA-29s inhibit cancer cell migration and invasion via targeting LAMC1 in prostate cancer. International journal of oncology 94 24820027
2015 miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer. Molecular endocrinology (Baltimore, Md.) 69 26052614
2006 Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse. Human genetics 62 17021862
2017 A functional polymorphism located at transcription factor binding sites, rs6695837 near LAMC1 gene, confers risk of colorectal cancer in Chinese populations. Carcinogenesis 61 28039327
2019 Lamc1 promotes the Warburg effect in hepatocellular carcinoma cells by regulating PKM2 expression through AKT pathway. Cancer biology & therapy 57 30755064
2021 LAMC1 upregulation via TGFβ induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-κB-CXCL1-STAT3. Molecular oncology 52 34218518
1998 The targeted deletion of the LAMC1 gene. Annals of the New York Academy of Sciences 44 9917858
2022 LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis. International journal of biological sciences 41 35541892
1997 Sp1-mediated transactivation of LamC1 promoter and coordinated expression of laminin-gamma1 and Sp1 in human hepatocellular carcinomas. The American journal of pathology 41 9403717
2013 Mutations in extracellular matrix genes NID1 and LAMC1 cause autosomal dominant Dandy-Walker malformation and occipital cephaloceles. Human mutation 39 23674478
1996 Isolation of a novel gene from the DiGeorge syndrome critical region with homology to Drosophila gdl and to human LAMC1 genes. Human molecular genetics 39 8733130
2021 LncRNA SNHG6 promotes breast cancer progression and epithelial-mesenchymal transition via miR-543/LAMC1 axis. Breast cancer research and treatment 27 33782812
2022 PSMA3-AS1 induced by transcription factor PAX5 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-376a-3p to up-regulate LAMC1. Aging 24 35022330
2012 LAMC1 gene is associated with premature ovarian failure. Maturitas 24 22321639
2016 MicroRNA-506 Inhibits Malignancy of Colorectal Carcinoma Cells by Targeting LAMC1. Annals of clinical and laboratory science 23 27993882
2022 The Endoplasmic Reticulum-Stressed Head and Neck Squamous Cell Carcinoma Cells Induced Exosomal miR-424-5p Inhibits Angiogenesis and Migration of Humanumbilical Vein Endothelial Cells Through LAMC1-Mediated Wnt/β-Catenin Signaling Pathway. Cell transplantation 21 35315295
2012 Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse. American journal of obstetrics and gynecology 18 22342894
2017 LAMC1 mRNA promotes malignancy of hepatocellular carcinoma cells by competing for MicroRNA-124 binding with CD151. IUBMB life 17 28524360
2024 LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage. Experimental neurology 15 38609046
2019 miR-506 contributes to malignancy of cutaneous squamous cell carcinoma via targeting of P65 and LAMC1. Cell cycle (Georgetown, Tex.) 12 30646812
1996 Expression of laminin gamma 1 cultured hepatocytes involves repeated CTC and GC elements in the LAMC1 promoter. The Biochemical journal 9 8611150
2023 NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1. Journal of neuro-oncology 8 37389756
2020 Common variants in LAMC1 confer risk for pelvic organ prolapse in Chinese population. Hereditas 8 32635941
2020 MiR-183 impeded embryo implantation by regulating Hbegf and Lamc1 in mouse uterus. Theriogenology 8 32980684
2022 LncRNA TM4SF19-AS1 exacerbates cell proliferation, migration, invasion, and EMT in head and neck squamous cell carcinoma via enhancing LAMC1 expression. Cancer biology & therapy 7 36411963
2024 Ginsenoside Rg1 Regulates the Activation of Astrocytes Through lncRNA-Malat1/miR-124-3p/Lamc1 Axis Driving PI3K/AKT Signaling Pathway, Promoting the Repair of Spinal Cord Injury. CNS neuroscience & therapeutics 6 39491316
2022 The long non-coding RNA ASMTL-AS1 promotes hepatocellular carcinoma progression by sponging miR-1343-3p that suppresses LAMC1 (laminin subunit gamma 1). Bioengineered 6 34859735
2022 Association of miRNA targetome variants in LAMC1 and GNB3 genes with colorectal cancer and obesity. Cancer medicine 6 35373932
2024 Lamc1 promotes osteogenic differentiation and inhibits adipogenic differentiation of bone marrow-derived mesenchymal stem cells. Scientific reports 5 39179716
2025 Serum Exosomal miR-216a Contributes to Acute Pancreatitis-Associated Acute Lung Injury by Enhancing Endothelial Cell Vascular Permeability Through Downregulating LAMC1. Pancreas 4 39937877
2024 Endothelial protein disulfide isomerase A1 enhances membrane stiffness and platelet-endothelium interaction in hyperglycemia via SLC3A2 and LAMC1. Journal of thrombosis and haemostasis : JTH 3 39128656
2023 Circ_0124208 Promotes the Progression of Hepatocellular Carcinoma by Regulating the miR-338-3p/LAMC1 Axis. Molecular biotechnology 3 36780058
2023 Hsa_circ_0005085 may suppress cutaneous squamous cell carcinoma growth and metastasis through targeting the miR-186-5p/LAMC1 axis. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 3 37357644
2022 Fuchs Endothelial Corneal Dystrophy associated risk variant, rs3768617 in LAMC1 shows allele specific binding of GFI1B. Gene 3 35031421
2022 Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux. PloS one 3 36417404
2023 A novel missense variant in LAMC1 identified in a POI family by whole exome sequencing. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2 37839437
2026 Astrocyte-derived LAMC1 protects against intracerebral hemorrhage: A novel genetic mechanism maintaining neurovascular integrity. Journal of advanced research 0 41534552
2025 Data-independent Acquisition Mass Spectrometry Reveals Exosomal LAMC1 as a Key Determinant of Lung Adenocarcinoma Radiosensitivity, Independent of EGFR Mutation. Current pharmaceutical design 0 40326033
2025 LAMC1 aggravates diabetic retinopathy through PI3K/AKT signaling-regulated epithelial-mesenchymal transition in retinal pigment epithelial cells. The journal of physiological sciences : JPS 0 41092639

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