KPNA5
Importin subunit alpha-6 · UniProt O15131
- Length
- 539 aa
- Mass
- 60.7 kDa
- Annotated
- 2026-06-13
21 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 21 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2014 | Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1. | Cell host & microbe | 187 | 25121748 |
| 2007 | An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury. | Cell | 133 | 17889653 |
| 2012 | Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers. | Genes, chromosomes & cancer | 63 | 22302350 |
| 2015 | Lloviu virus VP24 and VP35 proteins function as innate immune antagonists in human and bat cells. | Virology | 40 | 26255028 |
| 2017 | Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5. | Organic & biomolecular chemistry | 39 | 28574091 |
| 2017 | VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability. | Journal of virology | 33 | 27974555 |
| 2016 | Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses. | Scientific reports | 28 | 27009368 |
| 2022 | Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins. | Communications biology | 24 | 35022507 |
| 2015 | BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells. | PloS one | 23 | 26052702 |
| 2021 | Molecular profiling of nucleocytoplasmic transport factor genes in breast cancer. | Heliyon | 12 | 33553736 |
| 2023 | LncRNA SNHG6 Upregulates KPNA5 to Overcome Gemcitabine Resistance in Pancreatic Cancer via Sponging miR-944. | Pharmaceuticals (Basel, Switzerland) | 11 | 37259332 |
| 2021 | Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive Patients. | Viruses | 9 | 34696514 |
| 2017 | An all-atom molecular dynamics study of the anti-interferon signaling of Ebola virus: interaction mechanisms of EBOV VP24 binding to Karyopherin alpha5. | Molecular bioSystems | 9 | 28418440 |
| 2017 | Investigating Ebola virus pathogenicity using molecular dynamics. | BMC genomics | 8 | 28812539 |
| 2018 | Ebolavirus interferon antagonists-protein interaction perspectives to combat pathogenesis. | Briefings in functional genomics | 7 | 29140409 |
| 2025 | Mesenchymal Stem Cell-Derived Exosome miR-153-3 Induced M2-Type Polarization of Macrophages to Improve the Healing Effect of Burn Wounds. | Applied biochemistry and biotechnology | 5 | 40053206 |
| 2002 | Physical map of the chromosome 6q22 region containing the oculodentodigital dysplasia locus: analysis of thirteen candidate genes and identification of novel ESTs and DNA polymorphisms. | Cytogenetic and genome research | 5 | 12584438 |
| 2025 | MiR-153 Prevents NRF2 Nuclear Translocation to Drive Hypoperfusion-Related Cognitive Deficits by Targeting KPNA5. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 4 | 40816766 |
| 2025 | KPNA5 Suppresses Malignant Progression of Ovarian Cancer Through Importing the PTPN4 Into the Nucleus. | Cancer medicine | 2 | 40145330 |
| 2025 | The Biophysical Basis for Karyopherin-Dependent Ebola Virus VP24 Nuclear Transport. | Viruses | 1 | 40872766 |
| 2026 | Genome-wide association analysis for resistance against iridovirus disease in large yellow croaker (Larimichthys crocea) from a natural outbreak population. | Fish & shellfish immunology | 0 | 42235722 |
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