Affinage

KHSRP

Far upstream element-binding protein 2 · UniProt Q92945

Length
711 aa
Mass
73.1 kDa
Annotated
2026-06-10
100 papers in source corpus 41 papers cited in narrative 40 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KHSRP (KSRP) is a multifunctional single-strand nucleic-acid-binding protein with four KH domains that governs gene expression at the post-transcriptional level through three interlocking activities: ARE-directed mRNA decay, selective miRNA maturation, and pre-mRNA splicing control (PMID:15175153, PMID:19458619, PMID:27396342). As a decay factor, it binds AU-rich elements in target 3'-UTRs and recruits the exosome and the deadenylase PARN, with specific KH domains coupling RNA recognition to physical engagement of the degradation machinery; tethering KSRP to an mRNA is sufficient to trigger decay (PMID:15175153, PMID:16648466), and it extends this activity to translational silencing of ARE-containing transcripts (PMID:21795706). Domain-level structural work defines how it reads RNA: KH3 binds with highest affinity and recognizes G-rich sequences, while KH4 carries a conserved noncanonical element essential for ARE binding and decay (PMID:17437720, PMID:18684992), and a KH2–KH3 interdomain linker aligns the two central modules into a functional unit (PMID:20385598). The same G-rich recognition by KH3 underlies its second role as a component of both Drosha and Dicer complexes, where it binds the terminal loops of select pri/pre-miRNAs (e.g., let-7) to promote their maturation (PMID:19458619, PMID:23142982). In its third role it associates with hnRNP A1 and SF3B1 to direct alternative and constitutive splicing, including the founding c-src N1 exon enhancer activity and epithelial-type exon usage (PMID:9136930, PMID:39187547, PMID:26101706, PMID:28088441). These activities are toggled by an extensive regulatory layer: AKT phosphorylation of KH1 drives its unfolding, 14-3-3ζ binding, and nuclear sequestration away from cytoplasmic decay (PMID:17177604, PMID:19198587); p38 phosphorylation impairs ARE binding (PMID:16364914); SUMO1 modification at K87 blocks Drosha interaction and promotes nuclear export (PMID:29020972); and KLHL12-mediated ubiquitination, DDX1 competition, and SIRT7-opposed acetylation provide further control (PMID:27899653, PMID:24023901, PMID:38501452). Through these mechanisms KHSRP shapes diverse physiological programs including skeletal myogenesis, adipose biology, circadian/lipogenic control, axon regeneration, antiviral type I IFN responses, and tumorigenesis (PMID:21886180, PMID:24722250, PMID:25514904, PMID:35556128, PMID:21690298, PMID:39120596).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 1997 High

    Established KSRP as a sequence-specific splicing regulator, defining its founding biochemical activity and its four-KH-domain architecture before any decay role was known.

    Evidence Protein purification, cDNA cloning, and in vitro splicing assays with antibody inhibition rescued by purified protein at the c-src N1 intronic splicing enhancer

    PMID:9136930

    Open questions at the time
    • Did not define direct RNA contacts at residue resolution
    • Did not connect splicing role to subsequent decay or miRNA functions
  2. 2002 Medium

    Ortholog and degradation studies broadened the protein's recognized scope—RNA localization in oocytes and caspase cleavage—hinting at regulated turnover and developmental roles.

    Evidence Xenopus VgRBP71 RNA-binding and Prrp co-IP; in vitro caspase-3/-7 cleavage mapping of KSRP/FBP2

    PMID:12421702 PMID:12553859

    Open questions at the time
    • Functional consequence of caspase cleavage in cells not defined
    • Ortholog localization role not connected to mammalian decay function
  3. 2004 High

    Defined KSRP as an essential ARE-mediated decay factor that couples RNA binding to recruitment of the exosome and PARN, establishing its core post-transcriptional mechanism.

    Evidence In vitro mRNA decay assays, KH domain mutagenesis, and co-IP of KSRP with exosome and PARN

    PMID:15175153

    Open questions at the time
    • Did not resolve which KH domains contact ARE versus decay enzymes structurally
    • In vitro decay not yet linked to endogenous target half-lives
  4. 2005 High

    Showed signaling kinases gate decay activity and that KSRP competes with stabilizing factors, framing it as a regulated, antagonistic node in mRNA turnover.

    Evidence In vitro p38 kinase assay with ARE-binding comparison in myoblasts; iNOS ARE decay with HuR competition and TTP co-IP

    PMID:16126846 PMID:16364914

    Open questions at the time
    • p38 phosphorylation site(s) not mapped
    • Mechanism by which phospho-KSRP retains decay-enzyme binding but loses RNA binding unclear
  5. 2006 High

    Demonstrated that KSRP acts by recruiting decay machinery to transcripts and that AKT signaling inactivates this via 14-3-3, establishing a kinase-controlled decay switch.

    Evidence Rev-KSRP tethering decay assay; in vitro AKT kinase assay, 14-3-3 and exosome co-IP, and mRNA half-life measurements with phospho-site mutants

    PMID:16648466 PMID:17177604

    Open questions at the time
    • Tethering relied on heterologous RNA targeting
    • Single AKT serine not yet structurally explained
  6. 2007 High

    Resolved the structural logic of RNA recognition—KH3 highest-affinity G-rich binding, KH4 decay-critical element—and mapped the endogenous target repertoire.

    Evidence NMR structures of KH3/KH4 with ITC binding and mutagenesis; siRNA knockdown with IL-8 decay/deadenylation readouts and RNA pulldown-microarray

    PMID:17437720 PMID:17908789

    Open questions at the time
    • Full-length four-domain RNA complex not resolved
    • How individual domains combine on a single transcript not defined
  7. 2008 High

    Systematically defined the sequence selectivity of all four KH domains, explaining how one protein binds a broad but biased target range.

    Evidence Scaffold-independent NMR/ITC binding analysis of all four KH domains with selectivity assays

    PMID:18684992

    Open questions at the time
    • Selectivity measured per isolated domain, not in full-length context
    • In vivo target preference not directly tested here
  8. 2009 High

    Expanded KSRP from a decay factor into a miRNA biogenesis factor, showing it is part of Drosha and Dicer complexes and selectively promotes maturation of G-rich-loop precursors.

    Evidence Reciprocal co-IP with Drosha/Dicer, RIP, in vitro processing assays, KSRP knockdown miRNA profiling, and NMR binding

    PMID:19458619

    Open questions at the time
    • How the same protein partitions between decay and processing complexes not resolved
    • Determinants of precursor selectivity awaited later structural work
  9. 2009 High

    Provided the structural mechanism of AKT-driven nuclear sequestration, showing KH1 phosphorylation triggers unfolding and 14-3-3ζ-dependent relocalization, and confirmed exosome dependence for additional endoribonucleolytic targets.

    Evidence NMR of phospho/unphospho KH1 with 14-3-3ζ binding and localization assays; KSRP/PMR1/exosome co-IP and siRNA for PTH mRNA cleavage

    PMID:19198587 PMID:19775426

    Open questions at the time
    • Kinetics of nuclear-cytoplasmic shuttling in vivo not quantified
    • PMR1-KSRP findings from single lab
  10. 2010 High

    Established antagonistic and architectural controls on KSRP function: hnRNP A1 competes for let-7 terminal loops while the KH2–KH3 linker organizes the central RNA-binding unit, and KSRP destabilizes beta-catenin mRNA downstream of Dishevelled.

    Evidence In vitro Drosha processing with binding competition; NMR interdomain orientation analysis; Dvl affinity-MS, co-IP, and beta-catenin mRNA stability assays

    PMID:20332102 PMID:20385598 PMID:20639884

    Open questions at the time
    • How signaling redirects KSRP versus hnRNP A1 occupancy not fully defined
    • Dvl-KSRP interaction from a single study
  11. 2011 High

    Genetic and functional studies tied KSRP to antiviral IFN control, translational silencing, and a dual decay/miRNA switch in myogenesis, revealing how one protein executes opposing post-transcriptional outcomes.

    Evidence Ksrp-/- MEFs with viral infection and IFN mRNA decay; polysome profiling for IL-6/IL-1α silencing; C2C12 and Ksrp-/- mice with PI3K/AKT manipulation of decay versus miRNA maturation

    PMID:21690298 PMID:21795706 PMID:21886180

    Open questions at the time
    • Molecular basis distinguishing decay-competent from processing-competent KSRP pools not resolved
    • Translational silencing mechanism vs. decay not separated mechanistically
  12. 2012 High

    Defined the structural basis of let-7 precursor selectivity and showed signaling transducers (R-SMADs) and partner complexes (HuR) physically reconfigure KSRP activity in differentiation.

    Evidence NMR of KH3 bound to pre-let-7 G-rich loop with mutagenesis; phospho-SMAD/phospho-KSRP co-IP and SMAD knockdown rescue; HuR-KSRP-PARN-exosome co-IP for NPM mRNA

    PMID:23142982 PMID:23177623 PMID:24969639

    Open questions at the time
    • SMAD and HuR studies each from single labs
    • How phosphorylation enables SMAD binding to KSRP not mapped
  13. 2013 High

    Extended KSRP decay control to neuronal, circadian/metabolic, and muscle physiology and identified DDX1 as a competing localization regulator, establishing broad in vivo phenotypes.

    Evidence Ksrp-/- neurons and embryos with GAP-43/HuD competition and axon length; Ksrp-/- liver with Per2 decay and circadian/lipogenic readouts; utrophin A p38/ARE in mdx muscle; DDX1 affinity-MS, co-IP, and fractionation

    PMID:23575223 PMID:24023901 PMID:24244461 PMID:25514904

    Open questions at the time
    • Several metabolic and muscle studies from single labs
    • How DDX1 and 14-3-3 mutually exclusive binding is regulated unclear
  14. 2014 Medium

    Identified the H19 lncRNA as a scaffold for an AKT-regulated post-transcriptional switch and established direct KSRP→miRNA→target axes controlling adipose biology.

    Evidence RIP and in vitro binding for H19 scaffold with AKT-dependent dismissal in C2C12; Ksrp-/- adipose with miR-150→PRDM16/PPARGC1A and miR-145→FOXO1/CGI58 processing, reporter validation, and mimic rescue

    PMID:24722250 PMID:24732799 PMID:25385579

    Open questions at the time
    • H19 scaffolding mechanism from single lab
    • Whether scaffolding generalizes beyond myogenic context unknown
  15. 2016 High

    Revealed ubiquitin and miRNA-mediated control of KSRP and its role as a negative ITAF in IRES translation and an EMT-associated splicing/miRNA regulator.

    Evidence KLHL12 ubiquitination at K109/K121/K122 with site mutagenesis and IRES reporters; miR-27b-3p silencing of KHSRP with RNA-seq, hnRNPA1 co-IP, and splicing of Cd44/Fgfr2

    PMID:27396342 PMID:27899653

    Open questions at the time
    • Consequence of K109/121/122 ubiquitination on stability versus activity not fully separated
    • EMT splicing study from single lab
  16. 2017 High

    Showed SUMOylation directs KSRP localization and miRNA processing capacity and uncovered a non-RNA-decay role suppressing RIG-I innate immune sensing.

    Evidence SUMO1 modification at K87 with mutagenesis, fractionation, RIP, and miRNA-seq plus xenografts; co-IP of KHSRP with RIG-I regulatory domain and antiviral signaling assays

    PMID:28248290 PMID:29020972

    Open questions at the time
    • Interplay between SUMO, AKT-phospho, and ubiquitin marks not integrated
    • RIG-I suppression mechanism from single lab
  17. 2022 High

    Established axonal local translation and decay of KSRP targets as a brake on nerve regeneration and revealed direct chromatin occupancy linking KSRP to transcriptional control.

    Evidence Axoplasm proteomics, Ksrp-/- nerve injury with regeneration phenotype, axonal RIP/decay for Gap43/Snap25/Fubp1; ChIP-seq/RNA-seq/CLIP-seq in CD34+ monocytic differentiation

    PMID:35556128 PMID:36518592

    Open questions at the time
    • Mechanism of KSRP genomic recruitment to promoters/enhancers not defined
    • Direct versus indirect transcriptional effects not fully separated
  18. 2024 Medium

    Identified new molecular modalities—m6A reading, SF3B1-dependent branch-site splicing enhancement, and SIRT7-opposed acetylation—linking KHSRP to cancer and tissue injury.

    Evidence m6A-RIP and stability assays for MET/ITGAV/ITGB1 with FAK signaling in PDAC; KHSRP-SF3B1 co-IP with intron-retention RNA-seq in liver failure; SIRT7-KHSRP co-IP with DDR mRNA decay in prostate cancer

    PMID:38501452 PMID:39120596 PMID:39187547

    Open questions at the time
    • m6A-reader activity not structurally defined relative to KH domains
    • How acetylation, SUMO, and phosphorylation are coordinated unresolved
    • Each modality from a single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the dense network of post-translational modifications and competing partners is integrated to partition a single KHSRP molecule among decay, miRNA processing, splicing, m6A reading, and chromatin functions remains unresolved.
  • No unified model linking PTM combinations to functional outcome
  • No full-length structure showing domain coordination on physiological targets
  • Hierarchy and crosstalk among AKT, p38, SUMO, ubiquitin, and acetylation marks undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 6 GO:0060090 molecular adaptor activity 3 GO:0045182 translation regulator activity 2 GO:0140098 catalytic activity, acting on RNA 2
Localization
GO:0005829 cytosol 4 GO:0005634 nucleus 3
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-8953854 Metabolism of RNA 3 R-HSA-168256 Immune System 2
Partners
14-3-3 (YWHAZ)DDX1HNRNP A1HUR (ELAVL1)KLHL12PARNRIG-I (DDX58)SF3B1
Complex memberships
Dicer complexDrosha/DGCR8 microprocessorexosome

Evidence

Reading pass · 40 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 KSRP was purified and cloned as a component of a multiprotein complex binding to an intronic splicing enhancer downstream of the neuron-specific c-src N1 exon; antibodies to KSRP inhibited N1 exon splicing in vitro, and this inhibition was rescued by addition of purified KSRP; KSRP contains four KH RNA-binding domains and induces assembly of five other proteins including hnRNP F onto the splicing enhancer. Protein purification, cDNA cloning, in vitro splicing assay with antibody inhibition and rescue by purified protein, co-purification of multiprotein complex Genes & development High 9136930
2004 KSRP is an essential factor for ARE-directed mRNA decay; specific KH domains directly mediate RNA binding, mRNA decay, and physical interactions with the exosome and poly(A) ribonuclease (PARN); the ability of KH motifs to promote mRNA decay correlates with their ability to bind the ARE and associate with RNA-degrading enzymes. In vitro mRNA decay assays, domain mutagenesis, co-immunoprecipitation of KSRP with exosome and PARN, ARE-binding assays Molecular cell High 15175153
2005 p38α and p38β MAP kinase phosphorylates KSRP during muscle differentiation; p38-phosphorylated KSRP displays compromised binding to ARE-containing myogenic transcripts and fails to promote their rapid decay, although it retains ability to interact with mRNA degradation machinery; this stabilizes critical myogenic mRNAs and is required for proper myoblast-to-myocyte conversion. In vitro kinase assay (p38 phosphorylation of KSRP), RNA-binding assays with phosphorylated vs. unphosphorylated KSRP, KSRP overexpression in myoblasts with transcriptional and post-transcriptional readouts Molecular cell High 16364914
2005 KSRP binds the 3'-UTR ARE of human iNOS mRNA and promotes its decay by recruiting the exosome; KSRP competes with the stabilizing factor HuR for the same ARE binding site; KSRP also co-immunoprecipitates with tristetraprolin (TTP); a non-binding KSRP mutant fails to reduce iNOS expression, confirming the requirement for ARE binding. Immunodepletion in vitro degradation assays, overexpression of wild-type and non-binding mutant KSRP, co-immunoprecipitation with exosome and TTP, competition binding assay with HuR Nucleic acids research High 16126846
2006 AKT phosphorylates KSRP at a unique serine residue; this induces KSRP association with 14-3-3 proteins and prevents KSRP interaction with the exosome, impairing its ability to promote rapid mRNA decay; this mechanism stabilizes beta-catenin mRNA downstream of PI3K-AKT and Wnt signaling. In vitro AKT kinase assay, co-immunoprecipitation of KSRP with 14-3-3 and exosome under PI3K-AKT activation/inhibition, mRNA half-life measurements, mutagenesis of phosphorylation site PLoS biology High 17177604
2006 Tethering KSRP to mRNAs via fusion with sequence-specific RNA-binding proteins elicits mRNA decay in a manner dependent on known mRNA decay enzymes; this demonstrates that KSRP functions by recruiting mRNA decay machinery to target transcripts. Tethering assay using Rev-KSRP fusion protein targeting HIV-1 RRE; mRNA stability measurements; viral replication assays Molecular and cellular biology Medium 16648466
2007 The KH3 and KH4 domains of KSRP behave as independent RNA-binding modules recognizing different regions of AU-rich RNA targets; KH4 binds AREs with lower affinity than KH3; mRNA binding and mRNA degradation activities of KSRP are closely associated with a conserved structural element unique to KH4. NMR structure determination of KH3 and KH4, RNA-binding affinity measurements (ITC/NMR), mutagenesis of KH4 structural element Structure High 17437720
2007 KSRP knockdown by siRNA stabilizes IL-8 mRNA and impairs its rapid deadenylation; KSRP interacts with both domains of the bipartite IL-8 ARE; IL-1 treatment impairs the interaction of KSRP with the IL-8 ARE in a p38-dependent but MK2-independent manner; microarray pulldown identified ~100 mRNAs controlled by KSRP. siRNA knockdown, mRNA half-life and deadenylation assays, RNA pulldown with KSRP followed by microarray, co-immunoprecipitation, pharmacological inhibition of p38/MK2 Molecular and cellular biology High 17908789
2008 Among the four KH domains of KSRP, KH3 binds RNA with the highest affinity and specifically recognizes G-rich sequences; the other KH domains display different sequence preferences explaining the broad target range; KSRP shows strong negative selectivity for sequences with multiple adjacent cytosines. Scaffold-independent RNA-binding analysis of all four KH domains using NMR and ITC; systematic sequence selectivity assays Nucleic acids research High 18684992
2009 KSRP is a component of both Drosha and Dicer complexes; KSRP binds with high affinity to the terminal loop of target miRNA precursors and promotes their maturation; this function is required for specific changes in target mRNA expression affecting proliferation, apoptosis, and differentiation. Co-immunoprecipitation of KSRP with Drosha and Dicer complexes, RNA immunoprecipitation, in vitro processing assays, KSRP knockdown with miRNA profiling, NMR binding studies Nature High 19458619
2009 AKT-mediated phosphorylation of KSRP's KH1 domain causes KH1 unfolding (KH1 is structurally atypical and unstable), creating a binding site for 14-3-3ζ; 14-3-3ζ binding discriminates phosphorylated from unphosphorylated KH1 and drives nuclear localization of KSRP, sequestering it from cytoplasmic mRNA decay activity. NMR structure of KH1 (phosphorylated and unphosphorylated), 14-3-3ζ binding assays, localization studies, mRNA decay assays in cells with phosphomimetic/phosphodead mutants Nature structural & molecular biology High 19198587
2009 KSRP co-immunoprecipitates with PTH mRNA, the exosome, and the endoribonuclease PMR1; KSRP and exosome knockdown by siRNA prevents PMR1-mediated cleavage of PTH mRNA, establishing that PTH mRNA decay by PMR1 is dependent on both KSRP and the exosome. Co-immunoprecipitation of KSRP, PMR1, and exosome; siRNA knockdown of KSRP and exosome subunits; in vitro RNA cleavage assays BMC cell biology Medium 19775426
2010 hnRNP A1 binds the terminal loop of pri-let-7a-1 and inhibits Drosha processing; hnRNP A1 binding to let-7a interferes with KSRP binding to the same terminal loop, establishing antagonistic roles for hnRNP A1 (negative regulator) and KSRP (positive regulator) in let-7a biogenesis. RNA-protein binding competition assays, in vitro Drosha processing assays, cell-based depletion/overexpression of hnRNP A1 and KSRP with miRNA quantification Nature structural & molecular biology High 20639884
2010 KSRP interacts with Dishevelled (Dvl) proteins; KSRP negatively regulates Wnt/beta-catenin signaling by promoting post-transcriptional destabilization of CTNNB1 (beta-catenin) mRNA; identified by affinity purification coupled to ion-trap mass spectrometry. Affinity purification followed by mass spectrometry identification of KSRP as Dvl-binding protein; mRNA stability assays for beta-catenin mRNA; co-immunoprecipitation Journal of cell science Medium 20332102
2010 The inter-domain linker between KH2 and KH3 orients the two central KH domains of KSRP with their RNA-binding surfaces aligned, creating a two-domain unit; this interdomain arrangement is functionally important for interaction with KSRP's RNA targets. NMR structural analysis of interdomain linker and relative domain orientation; RNA binding assays comparing wild-type and linker-mutated constructs Nucleic acids research High 20385598
2011 KSRP is required for ARE-mediated decay of Ifna4 and Ifnb mRNAs; KSRP knockout mouse embryonic fibroblasts produce higher levels of type I IFN mRNAs following viral infection due to decreased mRNA decay; increased IFN expression renders Ksrp-/- cells refractory to HSV-1 and VSV infection. Ksrp knockout mouse MEFs, viral infection, mRNA half-life measurements, RNA immunoprecipitation, antiviral protection assays Molecular and cellular biology High 21690298
2011 KSRP participates in ARE-mediated translational silencing in addition to mRNA decay; KSRP depletion increases polysome association of IL-6 and IL-1α mRNAs; silencing depends on the 3'-UTR ARE of IL-6 mRNA; IL-1 reverses KSRP-dependent translational silencing. Polysome profiling after siRNA-mediated KSRP depletion, luciferase reporter assays with IL-6 3'UTR, KSRP-RNA interaction mapping The Journal of biological chemistry Medium 21795706
2011 PI3K/AKT activation regulates two distinct KSRP functions in opposite directions during skeletal myogenesis: it inhibits KSRP's ability to promote decay of myogenin mRNA while simultaneously activating its ability to favor maturation of myogenic miRNAs; this dynamic switch is required for the myogenic program as demonstrated in C2C12 cells and Ksrp knockout mice. C2C12 myoblast differentiation, Ksrp-/- mouse analysis, PI3K/AKT inhibition/activation, miRNA processing assays, mRNA stability measurements Cell death and differentiation High 21886180
2012 KSRP KH3 domain recognizes a G-rich sequence in the pre-let-7 terminal loop via a noncanonical KH-RNA interaction mode; the KH3-RNA complex structure reveals how this noncanonical binding governs KSRP selectivity for let-7 precursors; this selectivity is crucial for the functional interaction between KSRP and let-7 biogenesis. NMR structure of KH3 bound to pre-let-7 terminal loop G-rich sequence, mutagenesis of KH3 and RNA, functional processing assays Nature structural & molecular biology High 23142982
2012 HuR promotes myogenesis by associating with the decay factor KSRP and ribonucleases PARN and the exosome to destabilize nucleophosmin (NPM) mRNA; the C terminus of HuR mediates formation of the HuR-KSRP complex; this HuR-KSRP-PARN-exosome complex reduces NPM mRNA levels required for muscle cell commitment. Co-immunoprecipitation of HuR-KSRP complex, mRNA stability assays, domain deletion analysis of HuR, siRNA knockdown of HuR, overexpression studies Nature communications Medium 24969639
2012 Phosphorylated R-SMAD proteins (transducers of BMP2 signaling) associate with phosphorylated KSRP and block its interaction with primary myogenic miRNAs (myomiRs), preventing KSRP-dependent myomiR maturation; silencing SMAD4, SMAD5, and SMAD9 rescues KSRP function; this SMAD-mediated KSRP blockade is required for BMP2-induced osteoblastic differentiation. Co-immunoprecipitation of phospho-SMAD with phospho-KSRP, RNA immunoprecipitation, siRNA knockdown of SMADs, miRNA processing assays, cell differentiation readouts Cell reports Medium 23177623
2013 KSRP destabilizes GAP-43 mRNA by binding its ARE, a process requiring its KH4 domain; KSRP competes with the stabilizing factor HuD for binding to GAP-43 ARE sequences; KSRP overexpression hinders axonal outgrowth in primary hippocampal neurons, while KSRP knockdown increases GAP-43 mRNA and dramatically increases axonal length in both cultured neurons and Ksrp+/- and Ksrp-/- embryos. RNA-binding assays (KH domain deletion mutants), competition assays with HuD, overexpression/knockdown in primary hippocampal neurons, Ksrp knockout mouse neurons, axonal length measurements PloS one High 24244461
2013 KSRP promotes decay of Per2 mRNA via AU-rich elements in Per2's 3' UTR, and KSRP ablation increases Per2 expression causing a phase delay in circadian clock gene oscillations and reduced expression of de novo lipogenic genes, leading to reduced hepatic triglyceride accumulation. Ksrp-/- mouse liver analysis, heterologous mRNA reporter assays with Per2 3'UTR, mRNA half-life measurements in primary hepatocytes, circadian gene profiling Journal of lipid research Medium 25514904
2013 p38 activation increases utrophin A mRNA stability through AU-rich elements by reducing the functional availability of KSRP; KSRP directly binds AREs in the utrophin A 3'UTR; electroporation-mediated knockdown of KSRP increases utrophin A in wild-type and mdx mouse muscles. In vitro and in vivo KSRP-RNA binding studies, mRNA half-life assays, electroporation knockdown in mouse muscle, p38 activation with heparin in mdx mice Human molecular genetics Medium 23575223
2013 The RNA helicase DDX1 interacts with KSRP and regulates its subcellular localization; DDX1 knockdown elevates cytoplasmic levels of KSRP and facilitates ARE-mediated mRNA decay; KSRP associates with DDX1 or 14-3-3 proteins in a mutually exclusive manner, indicating competing interactions that regulate KSRP's cytoplasmic availability. Affinity purification and mass spectrometry identification of DDX1, co-immunoprecipitation, DDX1 siRNA knockdown, subcellular fractionation, mRNA decay assays PloS one Medium 24023901
2014 KSRP directly binds the H19 lncRNA in the cytoplasm of undifferentiated C2C12 cells, and this interaction facilitates KSRP-mediated destabilization of labile transcripts including myogenin mRNA; AKT activation induces KSRP dismissal from H19; upon dismissal, KSRP is repurposed to promote maturation of myogenic miRNAs; H19 thus acts as a molecular scaffold that optimizes an AKT-regulated post-transcriptional switch. RNA immunoprecipitation, in vitro RNA-protein binding assays, AKT activation/inhibition, mRNA stability assays, miRNA processing assays in C2C12 cells Proceedings of the National Academy of Sciences of the United States of America Medium 25385579
2014 KSRP ablation causes a reduction in body adiposity; in Ksrp-/- inguinal WAT, expression of miR-150 is decreased due to impaired primary miR-150 processing; miR-150 directly targets PRDM16 and PPARGC1A; forced miR-150 expression attenuates elevated brown fat gene expression caused by KSRP deletion, establishing a pathway KSRP → miR-150 → PRDM16/PPARGC1A controlling brown-like transformation of white fat. Ksrp-/- mouse analysis, miRNA processing assays, miRNA mimic rescue experiments, miR-150 target validation by luciferase assay Diabetes Medium 24722250
2014 In Ksrp-/- epididymal WAT, miR-145 expression is decreased due to impaired primary miR-145 processing; miR-145 directly targets and represses FOXO1 and CGI58, activators of lipolysis; forced miR-145 expression attenuates enhanced lipolysis in KSRP-deficient adipose tissue, establishing a KSRP → miR-145 → FOXO1/CGI58 pathway controlling adipose lipolysis. Ksrp-/- mouse WAT analysis, miRNA processing assays, miR-145 target validation by luciferase assay, miR-145 mimic rescue in primary adipocytes Molecular and cellular biology Medium 24732799
2016 KHSRP is ubiquitinated at Lys109, Lys121, and Lys122 by the Kelch domain of KLHL12 interacting with KHSRP's C-terminal domain; mutations at these sites abolish KHSRP's inhibitory effect on enterovirus IRES-driven translation; ubiquitination of KHSRP (a negative ITAF) thus controls IRES-dependent translation by limiting competition against positive ITAFs. In vivo and in vitro SUMOylation/ubiquitination assays, site-directed mutagenesis of ubiquitination sites, Ni2+-NTA pulldown, co-immunoprecipitation of KLHL12-KHSRP, IRES-luciferase reporter assays Nucleic acids research High 27899653
2016 miR-27b-3p-mediated silencing of KHSRP is required for TGF-β-induced EMT in mammary gland cells; KHSRP controls levels of mature miR-192-5p (targeting EMT factors) and promotes epithelial-type alternative splicing of pre-mRNAs including Cd44 and Fgfr2; KHSRP and hnRNPA1 cooperate in a ribonucleoprotein complex to promote epithelial exon usage. miR-27b-3p overexpression/knockdown, KHSRP knockdown/overexpression, genome-wide RNA-seq and miRNA-seq, co-immunoprecipitation of KHSRP-hnRNPA1 complex, splicing assays Cell reports Medium 27396342
2017 KHSRP is modified by SUMO1 at the major site K87; this modification inhibits KHSRP's interaction with pri-miRNA/Drosha-DGCR8 complex and promotes KHSRP translocation from nucleus to cytoplasm; SUMOylation consequently impairs processing of pre-miRNAs from pri-miRNAs with G-rich terminal loops (TL-G-Rich miRNAs including let-7 family), leading to tumorigenesis. In vivo and in vitro SUMOylation assays, site-directed mutagenesis (K87), nuclear/cytosol fractionation, immunofluorescence, RIP, high-throughput miRNA sequencing, xenograft tumor models Molecular cancer High 29020972
2017 KHSRP associates with the regulatory domain of RIG-I to maintain the receptor in an inactive state and attenuate its sensing of viral RNA; KHSRP knockdown enhances RIG-I antiviral signaling and reduces viral replication both in vitro and in vivo. RNAi screens integrated with interactome data, co-immunoprecipitation of KHSRP with RIG-I regulatory domain, RIG-I signaling assays upon KHSRP knockdown, in vitro and in vivo viral infection models Nature microbiology Medium 28248290
2002 Xenopus KSRP homolog VgRBP71 binds to mRNAs localized to either vegetal or animal hemispheres in oocytes but does not accumulate at the vegetal cortex with the mRNA; VgRBP71 interacts with Prrp (another Vg1 localization element-binding protein) in a manner that does not require Vg1 mRNA. Xenopus oocyte expression library screen, in vivo RNA-protein binding assays, co-immunoprecipitation of VgRBP71-Prrp interaction, localization studies Development Medium 12421702
2002 KSRP/FBP2 is cleaved by caspase-3 and caspase-7 at two sites: after Asp102 and after Asp183; the second cleavage site is only recognized in protein produced in cells (not in vitro translated protein), indicating that cellular context beyond primary sequence affects caspase recognition. In vitro caspase cleavage of KSRP with caspase-3 and -7, comparison of cellular vs. in vitro translated KSRP, site identification by mass spectrometry Protein and peptide letters Medium 12553859
2022 Khsrp mRNA localizes into peripheral nerve axons and is locally translated following axon injury; axonal KSRP levels rapidly increase after sciatic nerve injury and remain elevated; KHSRP binds to mRNAs with 3'UTR AU-rich elements (Gap43, Snap25, Fubp1) and targets them to the cytoplasmic exosome for degradation; Ksrp-/- mice show increased axonal levels of these target mRNAs and accelerated nerve regeneration in vivo. Targeted proteomics of axoplasm, Ksrp-/- mouse nerve injury model, local translation assay with axon ligation, RNA immunoprecipitation, mRNA stability measurements in axons, in vivo nerve regeneration assay Nucleic acids research High 35556128
2022 KHSRP regulates monocytic differentiation through both transcriptional and post-transcriptional mechanisms; KHSRP occupies specific genomic sites at promoter and enhancer regions to regulate hematopoietic gene transcription, and binds to pre-mRNA intronic regions to modulate alternative splicing; KHSRP has co-regulatory effects at both transcriptional and post-transcriptional levels on MOGOH and ADARB1. ChIP-seq, RNA-seq, CLIP-seq in CD34+ cells during monocytic differentiation, functional knockdown studies Blood science Medium 36518592
2024 KHSRP directly interacts with SF3B1 (splicing factor 3b subunit 1) and enhances SF3B1 binding to intronic branch sites, thereby promoting pre-mRNA splicing; KHSRP knockdown causes intron retention and exacerbates liver injury in acute liver failure models. Co-immunoprecipitation of KHSRP-SF3B1 interaction, RNA-seq analysis of splicing defects in KHSRP-knockdown cells and murine ALF models, splicing inhibitor experiments in vivo, proteomic and transcriptomic analyses Cell death & disease Medium 39187547
2024 KHSRP functions as an m6A-binding protein; KHSRP recognizes m6A modifications and stabilizes FAK pathway mRNAs including MET, ITGAV, and ITGB1 in an m6A-dependent manner, leading to activation of downstream FAK signaling and promotion of pancreatic ductal adenocarcinoma progression. m6A-RIP, RNA immunoprecipitation, KHSRP knockdown/overexpression with mRNA stability assays, FAK pathway activity assays, in vivo xenograft models, PROTAC-mediated KHSRP degradation Cancer research Medium 39120596
2024 SIRT7 is a deacetylase of KHSRP; androgen stimulation impairs SIRT7 interaction with KHSRP, leading to increased KHSRP acetylation; acetylated KHSRP has impaired mRNA decay activity for DDR-related mRNAs, promoting prostate cancer tumorigenesis. Co-immunoprecipitation of SIRT7-KHSRP interaction, acetylation assays under androgen stimulation, RNA-seq and GSEA for DDR gene changes, xenograft tumor growth with acetylation-site mutants Molecular oncology Medium 38501452
2015 KHSRP and hnRNPA1 form a ribonucleoprotein complex and cooperate to promote epithelial-type exon usage during splicing; combined silencing of both prevents RESV-dependent inclusion of epithelial-type exons in Cd44 pre-mRNA; hnRNP A1 also tethers KSRP to an exonic splicing silencer (ESS16) and KSRP binding to ESS16 requires hnRNP A1. Co-immunoprecipitation of KHSRP-hnRNPA1 complex, combined siRNA knockdown, splicing assays, 2D gel and mass spectrometry identification in erythroleukemia cells American journal of cancer research / Biochimica et biophysica acta Medium 26101706 28088441

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature 543 19458619
2004 A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. Molecular cell 375 15175153
1997 A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. Genes & development 300 9136930
2010 Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis. Nature structural & molecular biology 225 20639884
2005 p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Molecular cell 207 16364914
2005 Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR. Nucleic acids research 175 16126846
2016 Control of the negative IRES trans-acting factor KHSRP by ubiquitination. Nucleic acids research 129 27899653
2007 Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets. Molecular and cellular biology 128 17908789
2006 The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling. PLoS biology 119 17177604
2014 H19 long noncoding RNA controls the mRNA decay promoting function of KSRP. Proceedings of the National Academy of Sciences of the United States of America 107 25385579
2007 The structure of the C-terminal KH domains of KSRP reveals a noncanonical motif important for mRNA degradation. Structure (London, England : 1993) 101 17437720
2006 Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay. Molecular and cellular biology 101 16648466
2005 IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR. International journal of cancer 94 15514971
2009 Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding. Nature structural & molecular biology 90 19198587
2018 Long Noncoding RNA AB074169 Inhibits Cell Proliferation via Modulation of KHSRP-Mediated CDKN1a Expression in Papillary Thyroid Carcinoma. Cancer research 88 29735546
2012 miR-27b targets KSRP to coordinate TLR4-mediated epithelial defense against Cryptosporidium parvum infection. PLoS pathogens 85 22615562
2019 RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer. Journal of experimental & clinical cancer research : CR 83 31775888
2015 Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease. Wiley interdisciplinary reviews. RNA 81 26708421
2011 Posttranscriptional control of type I interferon genes by KSRP in the innate immune response against viral infection. Molecular and cellular biology 80 21690298
2011 PI3K/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis. Cell death and differentiation 70 21886180
2012 Functional and molecular insights into KSRP function in mRNA decay. Biochimica et biophysica acta 65 23178464
2023 Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner. International journal of biological sciences 63 37564198
2002 A homolog of FBP2/KSRP binds to localized mRNAs in Xenopus oocytes. Development (Cambridge, England) 63 12421702
2016 miRNA-Mediated KHSRP Silencing Rewires Distinct Post-transcriptional Programs during TGF-β-Induced Epithelial-to-Mesenchymal Transition. Cell reports 61 27396342
2014 Destabilization of nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fibre formation. Nature communications 60 24969639
2010 The role of KSRP in mRNA decay and microRNA precursor maturation. Wiley interdisciplinary reviews. RNA 60 21935887
2007 Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling. BMC molecular biology 55 17437629
2008 The sequence selectivity of KSRP explains its flexibility in the recognition of the RNA targets. Nucleic acids research 53 18684992
2021 Hypoxia-induced ebv-circLMP2A promotes angiogenesis in EBV-associated gastric carcinoma through the KHSRP/VHL/HIF1α/VEGFA pathway. Cancer letters 51 34863886
2014 KSRP ablation enhances brown fat gene program in white adipose tissue through reduced miR-150 expression. Diabetes 51 24722250
2011 Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type splicing regulatory protein (KSRP)-dependent translational silencing mechanism. The Journal of biological chemistry 49 21795706
2011 KSRP, many functions for a single protein. Frontiers in bioscience (Landmark edition) 48 21196264
2014 KSRP and MicroRNA 145 are negative regulators of lipolysis in white adipose tissue. Molecular and cellular biology 47 24732799
2014 KSRP controls pleiotropic cellular functions. Seminars in cell & developmental biology 47 24845017
2012 Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis. Nature structural & molecular biology 46 23142982
2012 KSRP: a checkpoint for inflammatory cytokine production in astrocytes. Glia 43 22847996
2017 KSRP suppresses cell invasion and metastasis through miR-23a-mediated EGR3 mRNA degradation in non-small cell lung cancer. Biochimica et biophysica acta. Gene regulatory mechanisms 41 28847731
2017 SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis. Molecular cancer 41 29020972
2013 Activation of p38 signaling increases utrophin A expression in skeletal muscle via the RNA-binding protein KSRP and inhibition of AU-rich element-mediated mRNA decay: implications for novel DMD therapeutics. Human molecular genetics 41 23575223
2010 Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of beta-catenin mRNA. Journal of cell science 41 20332102
2022 m6A transferase METTL3 regulates endothelial-mesenchymal transition in diabetic retinopathy via lncRNA SNHG7/KHSRP/MKL1 axis. Genomics 40 36174881
2013 KSRP modulation of GAP-43 mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons. PloS one 40 24244461
2021 LncRNA LINC01305 promotes cervical cancer progression through KHSRP and exosome-mediated transfer. Aging 38 33638945
2013 Regulation of miR-155 biogenesis in cystic fibrosis lung epithelial cells: antagonistic role of two mRNA-destabilizing proteins, KSRP and TTP. Biochemical and biophysical research communications 38 23524258
2010 Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets. Nucleic acids research 37 20385598
2016 KH-type splicing regulatory protein (KHSRP) contributes to tumorigenesis by promoting miR-26a maturation in small cell lung cancer. Molecular and cellular biochemistry 35 27644194
2011 Autoregulatory circuit of human rpL3 expression requires hnRNP H1, NPM and KHSRP. Nucleic acids research 34 21705779
2017 Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation. Nature microbiology 32 28248290
2022 Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs. Nucleic acids research 31 35556128
2017 KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nature communications 29 29127290
2022 The Role of KH-Type Splicing Regulatory Protein (KSRP) for Immune Functions and Tumorigenesis. Cells 28 35563788
2010 BRCA1 modulates the expression of hnRNPA2B1 and KHSRP. Cell cycle (Georgetown, Tex.) 28 21099359
2012 Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS genetics 27 22844247
2019 Inhibition of KHSRP sensitizes colorectal cancer to 5-fluoruracil through miR-501-5p-mediated ERRFI1 mRNA degradation. Journal of cellular physiology 26 31313286
2013 Converging pathways involving microRNA-206 and the RNA-binding protein KSRP control post-transcriptionally utrophin A expression in skeletal muscle. Nucleic acids research 26 24371285
2021 LncRNA HOTTIP facilitates cell proliferation, invasion, and migration in osteosarcoma by interaction with PTBP1 to promote KHSRP level. Cell cycle (Georgetown, Tex.) 25 33475442
2020 KHSRP-bound small nucleolar RNAs associate with promotion of cell invasiveness and metastasis of pancreatic cancer. Oncotarget 25 32010427
2012 Bone morphogenetic protein/SMAD signaling orients cell fate decision by impairing KSRP-dependent microRNA maturation. Cell reports 24 23177623
2019 Oxymatrine ameliorates insulin resistance in rats with type 2 diabetes by regulating the expression of KSRP, PETN, and AKT in the liver. Journal of cellular biochemistry 23 31087709
2017 K-homology splicing regulatory protein (KSRP) promotes post-transcriptional destabilization of Spry4 transcripts in non-small cell lung cancer. The Journal of biological chemistry 23 28275056
2020 Upregulation of KSRP by miR-27b attenuates schistosomiasis-induced hepatic fibrosis by targeting TGF-β1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22 31953889
2014 KHSRP participates in manganese-induced neurotoxicity in rat striatum and PC12 cells. Journal of molecular neuroscience : MN 21 25027559
2014 Role of KSRP in control of type I interferon and cytokine expression. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20 24697204
2021 A new KSRP-binding compound suppresses distant metastasis of colorectal cancer by targeting the oncogenic KITENIN complex. Molecular cancer 19 34039363
2017 Resveratrol limits epithelial to mesenchymal transition through modulation of KHSRP/hnRNPA1-dependent alternative splicing in mammary gland cells. Biochimica et biophysica acta. Gene regulatory mechanisms 19 28088441
2014 KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression. Journal of lipid research 18 25514904
2011 KSRP Promotes the Maturation of a Group of miRNA Precuresors. Advances in experimental medicine and biology 18 21755471
2010 KSRP promotes the maturation of a group of miRNA precursors. Advances in experimental medicine and biology 18 21627028
2009 KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells. BMC cell biology 18 19775426
2023 The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase. Journal of biomedical science 17 37580757
2022 KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization. Communications biology 17 35798971
2019 The RNA-Binding Protein KSRP Modulates Cytokine Expression of CD4+ T Cells. Journal of immunology research 17 31511826
2010 KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue. ACS medicinal chemistry letters 17 24900207
2021 Fangchinoline suppresses conjunctival melanoma by directly binding FUBP2 and inhibiting the homologous recombination pathway. Cell death & disease 14 33828201
2020 FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells. Communications biology 14 33005010
2016 Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth. Nucleic acids research 14 27207882
2016 The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells. Biochimica et biophysica acta 14 27478153
2024 KHSRP Stabilizes m6A-Modified Transcripts to Activate FAK Signaling and Promote Pancreatic Ductal Adenocarcinoma Progression. Cancer research 13 39120596
2019 KSRP modulates melanoma growth and efficacy of vemurafenib. Biochimica et biophysica acta. Gene regulatory mechanisms 13 31269460
2017 Inactivation of the KSRP gene modifies collagen antibody induced arthritis. Molecular immunology 13 28511090
2024 KHSRP has oncogenic functions and regulates the expression and alternative splicing of DNA repair genes in breast cancer MDA-MB-231 cells. Scientific reports 12 38926398
2022 KHSRP modulated cell proliferation and cell cycle via regulating PPP2CA and p27 expression in Wilms tumor. Cellular signalling 12 36029941
2022 Blockage of KHSRP-NLRP3 by MCC950 Can Reverse the Effect of Manganese-Induced Neuroinflammation in N2a Cells and Rat Brain. International journal of molecular sciences 12 36362011
2022 KHSRP combines transcriptional and posttranscriptional mechanisms to regulate monocytic differentiation. Blood science (Baltimore, Md.) 12 36518592
2015 Upregulation of KSRP by miR-27b provides IFN-γ-induced post-transcriptional regulation of CX3CL1 in liver epithelial cells. Scientific reports 12 26631623
2019 The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally. The Biochemical journal 11 30578289
2013 DEAD box protein DDX1 regulates cytoplasmic localization of KSRP. PloS one 11 24023901
2011 ATM signals miRNA biogenesis through KSRP. Molecular cell 11 21329874
2024 LncRNA lnc-SPRR2G-2 contributes to keratinocyte hyperproliferation and inflammation in psoriasis by activating the STAT3 pathway and downregulating KHSRP. Molecular and cellular probes 10 38942130
2013 Spatiotemporal expression of KHSRP modulates Schwann cells and neuronal differentiation after sciatic nerve injury. The international journal of biochemistry & cell biology 9 24368152
1999 Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17. Genomics 9 10087204
2013 KSRP silencing favors neural differentiation of P19 teratocarcinoma cells. Biochimica et biophysica acta 8 23462617
2024 The mRNA-Binding Protein KSRP Limits the Inflammatory Response of Macrophages. International journal of molecular sciences 7 38612694
2024 Emodin disrupts the KITENIN oncogenic complex by binding ErbB4 and suppresses colorectal cancer progression in dual blockade with KSRP-binding compound. Phytomedicine : international journal of phytotherapy and phytopharmacology 7 39586126
2020 Generation of multiple iPSC clones from a male schizophrenia patient carrying de novo mutations in genes KHSRP, LRRC7, and KIR2DL1, and his parents. Stem cell research 7 33503521
2002 Biochemical characterization of apoptotic cleavage of KH-type splicing regulatory protein (KSRP)/far upstream element-binding protein 2 (FBP2). Protein and peptide letters 7 12553859
2025 A novel taxane SB-T-101141 triggers a noncanonical ferroptosis to overcome Paclitaxel resistance of breast cancer via iron homeostasis-related KHSRP. Cell death & disease 6 40389408
2024 Acetylated KHSRP impairs DNA-damage-response-related mRNA decay and facilitates prostate cancer tumorigenesis. Molecular oncology 6 38501452
2024 KHSRP ameliorates acute liver failure by regulating pre-mRNA splicing through its interaction with SF3B1. Cell death & disease 5 39187547
2015 HnRNP A1 tethers KSRP to an exon splicing silencer that inhibits an erythroid-specific splicing event in PU.1-induced erythroleukemia. American journal of cancer research 5 26101706

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