Affinage

KCNB2

Potassium voltage-gated channel subfamily B member 2 · UniProt Q92953

Length
911 aa
Mass
102.6 kDa
Annotated
2026-06-10
22 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KCNB2 encodes Kv2.2, a voltage-gated delayed rectifier K+ channel that tunes neuronal excitability and endocrine secretion by shaping repolarization during sustained electrical activity (PMID:18511484, PMID:23699522). In auditory brainstem neurons it concentrates at the axon initial segment, where it contributes little to single spikes but hyperpolarizes interspike potentials during repetitive firing, promoting recovery of voltage-gated Na+ channels from inactivation and thereby sustaining high-frequency action potential firing (PMID:18511484, PMID:23699522). Its functional output is set by subunit context: Kv2.2 physically interacts with Kv2.1 and acts as a negative modulator of the resulting heteromeric current (PMID:23788641), co-assembles with the electrically-silent KvS subunit Kv6.4 at ER-PM junctions and supports Kv6.4 clustering [PMID:bio_10.1101_2025.06.04.657913], and binds the t-SNARE syntaxin 1A in a manner distinct from Kv2.1 (PMID:16754785), while the accessory subunit mKvbeta4 selectively boosts Kv2.2 surface expression through its C-terminus (PMID:8824288). Channel activity is further controlled by post-translational modification, being inhibited by PKC phosphorylation at S481/S488 (PMID:34542799) and by PKA phosphorylation at S448 downstream of PGE2/EP2-4 signaling (PMID:40028769), yet activated by a non-genomic membrane glucocorticoid receptor pathway acting through ERK1/2 (PMID:38075025). Beyond neurons, Kv2.2 governs hormone secretion in pancreatic islets, selectively restraining somatostatin release from delta-cells (PMID:23161216) and modulating glucose-stimulated insulin secretion via its interaction with Kv2.1 and the EP2/4-PKA axis (PMID:23788641, PMID:40028769). KCNB2 expression is itself regulated transcriptionally and post-transcriptionally, being a direct target of miR-1 (PMID:24386485) and repressed by EZH2-mediated H3K27me3 at its promoter (PMID:37645613).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 1996 Medium

    Established that Kv2.2 surface expression is governed by a dedicated accessory subunit, distinguishing its regulation from the paralog Kv2.1.

    Evidence Xenopus oocyte co-expression with mKvbeta4 and Kv2.1/Kv2.2 chimeric mapping

    PMID:8824288

    Open questions at the time
    • Chaperone-like mechanism inferred but not biochemically resolved
    • Physiological relevance in native neurons not tested
  2. 1999 Medium

    Showed Kv2.2 is a downstream effector of GPCR signaling, linking AT1 receptor activation to suppression of K+ current and increased neuronal firing.

    Evidence Patch-clamp of neuronal cocultures plus AT1/Kv2.2 co-expression in oocytes

    PMID:10024310

    Open questions at the time
    • Molecular mechanism of inhibition not defined
    • No phosphorylation site identified
  3. 2004 Medium

    Mapped a proximal C-terminal domain controlling developmental, stage-specific restriction of Kv2.2 functional density.

    Evidence Chimeric Kv2.1/Kv2.2 subunit expression in Xenopus embryos and oocytes

    PMID:15306626

    Open questions at the time
    • Binding partners mediating proxC restriction unknown
    • Restricted to amphibian development
  4. 2006 Medium

    Defined a paralog-specific SNARE interaction, showing Kv2.2 binds syntaxin 1A but is insensitive to the syntaxin/SNAP-25 complex, implying a distinct role in islet hormone secretion.

    Evidence Two-electrode voltage clamp with syntaxin 1A/SNAP-25 co-expression plus islet immunohistochemistry

    PMID:16754785

    Open questions at the time
    • Direct effect on glucagon/somatostatin secretion not measured here
    • C-terminal determinant of selectivity not mutationally mapped
  5. 2008 High

    Resolved the core neuronal function of Kv2.2: AIS-localized channels hyperpolarize interspike potentials to enable Nav recovery and high-frequency firing.

    Evidence RT-PCR, immunofluorescence, KO tissue Western blot, patch-clamp, and Hodgkin-Huxley modelling in MNTB neurons

    PMID:18511484

    Open questions at the time
    • Did not address heteromerization with Kv2.1 in this context
    • AIS targeting mechanism not defined
  6. 2008 Medium

    Demonstrated axonal localization of Kv2.2 distinct from somatodendritic Kv2.1, supporting divergent paralog roles.

    Evidence Specificity-controlled immunodetection and confocal imaging in Xenopus neurons

    PMID:18680201

    Open questions at the time
    • Trafficking determinants not identified
    • Tubulin colocalization mechanism unresolved
  7. 2010 Medium

    Identified a defined Kv2.2-expressing cell population, GABAergic basal forebrain neurons, anchoring later circuit-level studies.

    Evidence Immunolabeling combined with GAD67-GFP knockin reporter mice

    PMID:20853508

    Open questions at the time
    • Functional consequence in these neurons not tested here
  8. 2012 High

    Established a non-redundant endocrine role: Kv2.2 selectively controls somatostatin secretion from pancreatic delta-cells independent of Kv2.1.

    Evidence shRNA knockdown, GxTX-1E/RY796 pharmacology, and Kv2.1 KO islet/pancreas secretion assays

    PMID:23161216

    Open questions at the time
    • Coupling between channel activity and somatostatin exocytosis not mechanistically dissected
  9. 2013 High

    Connected Kv2.2 to auditory function, showing it maintains short APs and high-frequency firing and protects against noise-induced hearing loss.

    Evidence Dominant-negative viral transfer, Kv2.2 KO mice, patch-clamp, and auditory brainstem responses

    PMID:23699522

    Open questions at the time
    • Subunit composition of native VNTB currents not defined
  10. 2013 Medium

    Showed Kv2.2 is a direct miR-1 target, linking microRNA regulation of KCNB2 to atrial electrical remodeling.

    Evidence Luciferase reporter assay plus miR-1 overexpression/knockdown and electrophysiology

    PMID:24386485

    Open questions at the time
    • Cardiac Kv2.2 channel function not directly recorded
    • Relative contribution versus KCNE1 not separated
  11. 2013 Medium

    Demonstrated Kv2.2 physically interacts with Kv2.1 and negatively modulates the heteromeric current, integrating it into beta-cell metabolic control of insulin secretion.

    Evidence Co-immunoprecipitation, co-overexpression patch-clamp, and ICDc knockdown/rescue epistasis in islet beta-cells

    PMID:23788641

    Open questions at the time
    • Stoichiometry of Kv2.1/Kv2.2 heteromers undefined
    • Structural basis of negative modulation unknown
  12. 2013 Medium

    Linked Kv2.2 to behavioral physiology by showing its loss alters sleep-wake architecture via basal forebrain GABAergic neurons.

    Evidence Kv2.2 KO mice with EEG/EMG recordings and c-Fos activity mapping

    PMID:24293758

    Open questions at the time
    • Cell-autonomous channel contribution not isolated from network effects
  13. 2021 High

    Identified PKC phosphorylation sites S481/S488 as an inhibitory switch on Kv2.2 controlling cortical neuron firing.

    Evidence PKC activation in HEK293, S481A/S488A mutagenesis, phospho-antibodies, and native cortical neuron patch-clamp

    PMID:34542799

    Open questions at the time
    • Upstream receptor coupling to PKC not specified
    • Interaction with other phospho-regulation not tested
  14. 2021 Medium

    Defined a conserved inter-subunit W366-Y376 hydrogen bond required for K+ conductance, a structural determinant distinct from Shaker inactivation.

    Evidence Point mutagenesis and patch-clamp across Kv2.1, Kv2.2, and Kv1.2

    PMID:33803465

    Open questions at the time
    • No structural model of the bonded state
    • Single method, functional inference only
  15. 2023 Medium

    Revealed a rapid non-genomic glucocorticoid pathway that activates Kv2.2 via a membrane GR and ERK1/2, modulating neuronal firing and synaptic depression.

    Evidence Single-channel patch-clamp in HEK293, U0126 inhibition, membrane-impermeable agonist, and brain slice recordings

    PMID:38075025

    Open questions at the time
    • Direct ERK1/2 phosphorylation site on Kv2.2 not mapped
    • Membrane GR identity not molecularly defined
  16. 2023 Medium

    Established epigenetic repression of KCNB2 by EZH2-mediated H3K27me3, linking matrix conditions to channel downregulation in bladder smooth muscle.

    Evidence ChIP for H3K27me3 at the KCNB2 promoter, EZH2 inhibition, and KCNB2 siRNA

    PMID:37645613

    Open questions at the time
    • Smooth muscle Kv2.2 channel function not electrophysiologically characterized
    • Direct EZH2-KCNB2 causality versus broader program not fully separated
  17. 2025 High

    Identified PKA phosphorylation at S448 as the molecular basis for PGE2/EP2-4 inhibition of Kv2.2, with in vivo consequences for glucose homeostasis.

    Evidence S448A mutagenesis, EP receptor pharmacology, INS-1 electrophysiology, and Kcnb2 KO glucose tolerance/GSIS

    PMID:40028769

    Open questions at the time
    • Cell-type specificity of the EP2/4-PKA-Kv2.2 axis beyond beta-cells not resolved
  18. 2025 Medium

    Showed Kv2.2 co-assembles with Kv6.4 and clusters with Kv2.1 at ER-PM junctions, supporting localization of silent subunits and auxiliary AMIGO-1.

    Evidence Immunofluorescence colocalization with Kv2.1 S590A and Kv2.1/Kv2.2 KO mice plus super-resolution microscopy (preprint)

    PMID:bio_10.1101_2025.06.04.657913

    Open questions at the time
    • Functional output of Kv2.2/Kv6.4 heteromers not recorded
    • Preprint, not yet peer-reviewed

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the multiple regulatory inputs (PKC, PKA, ERK1/2, subunit composition) are integrated to set Kv2.2 output in a given cell type, and the structural basis of its negative modulation of Kv2.1, remain unresolved.
  • No integrated model of competing phospho-regulation
  • Heteromer structure and stoichiometry undefined
  • Native channel composition across neuronal and endocrine cell types incompletely mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 3
Localization
GO:0005886 plasma membrane 3 GO:0005783 endoplasmic reticulum 1 GO:0005856 cytoskeleton 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-112316 Neuronal System 2
Partners
AMIGO1KCNAB4KCNB1KCNG4STX1A
Complex memberships
ER-PM junction Kv2 clusterKv2.1/Kv2.2 heteromeric channelKv2.2/Kv6.4 heteromeric channel

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 A novel beta subunit, mKvbeta4, specifically associates with Kv2.2 (CDRK/KCNB2) but not the closely related Kv2.1, enhancing Kv2.2 expression level up to 6-fold at the plasma membrane without changing its elementary conductance or kinetics. The C-terminal end of Kv2.2 is essential for mKvbeta4 sensitivity. The effect is proposed to be chaperone-like, permitting integration of more channels at the plasma membrane. Xenopus oocyte co-expression, chimeric channel analysis between Kv2.1 and Kv2.2, co-localization of transcripts in brain The Journal of biological chemistry Medium 8824288
1999 Angiotensin II, acting through AT1 receptors, inhibits Kv2.2 currents in hypothalamic/brainstem neurons. Co-expression of Kv2.2 and the AT1 receptor in Xenopus oocytes confirmed Ang II-induced inhibition of Kv2.2 current. This inhibition contributes to increased neuronal firing rate relevant to cardiovascular regulation. Patch-clamp electrophysiology of neuronal cocultures, Xenopus oocyte co-expression, RT-PCR, Western blot, pharmacological dissection Circulation research Medium 10024310
2004 The proximal carboxyl terminus (proxC domain) of Kv2.2 mediates a developmental, subunit-specific regulation of channel density in Xenopus spinal neurons. Kv2.2 overexpression increases IKv density in young but not mature neurons; chimeric Kv2 subunits lacking the proxC domain of Kv2.2 rescued current density increase in mature neurons, identifying proxC as responsible for restricting functional expression at mature stages. Chimeric Kv2.1/Kv2.2 subunit expression in Xenopus embryos, heterologous expression in oocytes, in vivo current measurements Journal of neurophysiology Medium 15306626
2006 Kv2.2 interacts with syntaxin 1A (a t-SNARE) but, unlike Kv2.1, does not interact with the syntaxin 1A/SNAP-25 complex and is therefore insensitive to the assembly/disassembly state of this SNARE complex. This distinct regulation is attributed to differences in the C-termini of Kv2.1 and Kv2.2. Immunohistochemistry showed Kv2.2 is the dominant Kv channel in pancreatic alpha and delta cells (not beta cells), suggesting SNARE-Kv2.2 interactions regulate glucagon and somatostatin secretion. Two-electrode voltage clamp in Xenopus oocytes, immunohistochemistry, comparative functional analysis of Kv2.1 vs Kv2.2 with syntaxin 1A and SNAP-25 co-expression Molecular pharmacology Medium 16754785
2008 Kv2.2 channels are highly expressed at the axon initial segment of MNTB neurons. Hodgkin-Huxley modelling and current-clamp recordings demonstrated that Kv2.2 plays a minor role during single action potentials but hyperpolarizes interspike potentials during repetitive firing, thereby assisting recovery of voltage-gated sodium channels from inactivation and maintaining action potential amplitude at high frequencies. Quantitative RT-PCR, immunofluorescence confocal imaging, Western blot (including Kv2.2 knockout tissue), patch-clamp electrophysiology, Hodgkin-Huxley modelling The Journal of physiology High 18511484
2008 In Xenopus laevis neurons, Kv2.2 protein localizes to long axonal-like processes and colocalizes with alpha-tubulin intracellularly, contrasting with Kv2.1 which is somatodendritic. This differential subcellular localization supports distinct functional roles for the two paralogs during development. Antibody development and immunodetection in Xenopus embryos and cultured neurons, Western blot specificity confirmation (Kv2.2 vs Kv2.1), confocal imaging The Journal of comparative neurology Medium 18680201
2010 Kv2.2 is abundantly expressed in a large subpopulation (~60%) of GABAergic neurons in the magnocellular preoptic nucleus (MCPO) and horizontal limb of the diagonal band of Broca (HDB) of the basal forebrain, identified using specific immunolabeling and GFP-knockin mice expressing GFP in GABAergic neurons. Immunolabeling, GFP-knockin reporter mice (GAD67-GFP), confocal microscopy The Journal of comparative neurology Medium 20853508
2012 Kv2.2 specifically regulates somatostatin release from pancreatic delta-cells. shRNA-mediated knockdown of Kv2.2 in mouse islets selectively enhanced somatostatin secretion without affecting insulin secretion. Pharmacological inhibition with GxTX-1E (which blocks both Kv2.1 and Kv2.2) also enhanced somatostatin release, including in Kv2.1 knockout mice, confirming a Kv2.2-dependent mechanism in delta-cells. Adenovirus-delivered shRNA knockdown, selective peptide (GxTX-1E) and small molecule (RY796) inhibitors, Kv2.1 knockout mice, isolated islet secretion assays, perfused pancreata The Journal of pharmacology and experimental therapeutics High 23161216
2013 Kv2.2 regulates neuronal excitability in VNTB neurons of the medial olivocochlear system by maintaining short action potentials and enabling high-frequency firing. Viral dominant-negative Kv2.2 gene transfer suppressed outward K+ currents, increased AP half-width, and reduced repetitive firing. Kv2.2 knockout mice showed the same AP duration increase and were more susceptible to noise-induced hearing loss. Viral gene transfer of dominant-negative Kv2.2, Kv2.2 knockout mice, patch-clamp electrophysiology, in vivo auditory brainstem response recordings The Journal of neuroscience High 23699522
2013 miR-1 targets KCNB2 (and KCNE1) directly, as confirmed by luciferase activity assay. Upregulation of miR-1 during atrial tachypacing downregulates KCNB2, contributing to shortening of atrial effective refractory period and increased IKs. Luciferase reporter assay (direct target confirmation), lentiviral miR-1 overexpression, siRNA knockdown, patch-clamp, in vivo AERP measurement PloS one Medium 24386485
2013 Pyruvate-isocitrate cycling (via cytosolic NADP-dependent isocitrate dehydrogenase, ICDc) regulates Kv2.2 expression in islet beta-cells. Immunoprecipitation demonstrated physical interaction between Kv2.1 and Kv2.2. Co-overexpression of Kv2.1 and Kv2.2 reduced outward K+ current compared with Kv2.1 alone, supporting Kv2.2 as a negative modulator of Kv channel activity. Kv2.2 knockdown rescued the GSIS defect caused by ICDc knockdown. siRNA knockdown, adenoviral re-expression, co-immunoprecipitation, patch-clamp electrophysiology, selective inhibitor stromatoxin1 The Journal of biological chemistry Medium 23788641
2013 Kv2.2-expressing GABAergic neurons in the basal forebrain are preferentially active during waking (c-Fos labeling) and regulate the sleep-wake cycle. Kv2.2 knockout mice exhibited longer consolidated wake bouts and reduced delta-frequency EEG activity during NREM sleep. Basal forebrain GABAergic neurons showed augmented c-Fos expression in Kv2.2 knockout mice. Kv2.2 knockout mice, EEG/EMG sleep recordings, c-Fos immunostaining, sleep deprivation protocol Sleep Medium 24293758
2021 Protein kinase C (PKC) phosphorylates Kv2.2 at residues S481 and S488, inhibiting Kv2.2 currents and altering steady-state activation. Point mutations at S481 and S488 abolished PKC-dependent modulation. In cortical layer II pyramidal neurons, PKC activation similarly inhibited native Kv2.2 channels and reduced action potential firing frequency. PKC activation in HEK293 cells expressing Kv2.2, point mutagenesis (S481A, S488A), phospho-specific antibodies, patch-clamp in native cortical neurons Neuroscience bulletin High 34542799
2021 An inter-subunit hydrogen bond formed by W366 and Y376 (Kv2.1 numbering; conserved in Kv2.2) is essential for K+ conductance. Mutations disrupting this H-bond caused complete loss of K+ conductance in Kv2.1, Kv2.2, and Kv1.2 channels, differing from the Shaker inactivation mechanism. Point mutagenesis, patch-clamp recording in cells expressing Kv2.2 and related channels Membranes Medium 33803465
2023 Cortisol (glucocorticoid) rapidly increases Kv2.2 currents by increasing single-channel open probability through activation of a membrane-associated glucocorticoid receptor, independent of genomic signaling. This effect is mediated through the ERK1/2 kinase pathway (blocked by U0126). A membrane-impermeable glucocorticoid receptor agonist (BSA-dexamethasone) mimicked the effect. In cortical pyramidal neurons and calyx of Held synapses, cortisol suppressed AP firing frequency and increased activity-dependent synaptic depression via Kv2.2 activation. Single-channel patch-clamp in HEK293 cells expressing Kv2.2, pharmacological inhibition (U0126, EP receptor antagonists), membrane-impermeable agonist, patch-clamp in acute brain slices Neurobiology of stress Medium 38075025
2023 EZH2-mediated H3K27me3 histone trimethylation at the KCNB2 promoter (CpG island and upstream region) represses KCNB2 expression in bladder smooth muscle cells during obstruction. EZH2 inhibition (UNC1999) restored KCNB2 expression and partially restored smooth muscle cell phenotype. Matrix conditions regulate EZH2 and H3K27me3 levels affecting KCNB2 expression. ChIP/PCR for H3K27me3 at KCNB2 promoter in obstruction tissue, EZH2 inhibitor treatment, siRNA knockdown of KCNB2, Western blotting, immunostaining American journal of clinical and experimental urology Medium 37645613
2025 PGE2 inhibits Kv2.2 channels via PKA-dependent phosphorylation at residue S448, acting through EP2/4 receptors. Point mutation of S448 blocked the PKA-dependent PGE2 inhibition. In INS-1 beta-cells, PGE2 inhibited voltage-gated K+ currents and electrical activity through EP2/4 receptors and Kv2.2. Kcnb2 knockout mice showed abrogated PGE2-induced glucose intolerance, and Kv2.2 knockdown alleviated PGE2 inhibition of GSIS. HEK293T overexpression, point mutagenesis (S448A), PKA pathway manipulation, EP receptor antagonists/agonists, INS-1 beta-cell electrophysiology, Kcnb2 knockout mice, glucose tolerance testing, islet GSIS assays eLife High 40028769
2025 Kv2.2 co-assembles with the electrically-silent subunit Kv6.4 and co-clusters with Kv2.1 at endoplasmic reticulum-plasma membrane (ER-PM) junctions beneath C-bouton synapses in spinal motor neurons. In Kv2.2 knockout mice, Kv6.4 clustering at ER-PM junctions is moderately reduced, indicating that Kv2.2 contributes to the localization and expression of Kv6.4 through co-assembly. AMIGO-1 auxiliary subunit clustering is also moderately reduced in Kv2.2 KO mice. Immunofluorescence co-localization, Kv2.1 S590A mutant mice, Kv2.1 and Kv2.2 knockout mice, confocal and super-resolution microscopy bioRxivpreprint Medium bio_10.1101_2025.06.04.657913

Source papers

Stage 0 corpus · 22 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 Initial segment Kv2.2 channels mediate a slow delayed rectifier and maintain high frequency action potential firing in medial nucleus of the trapezoid body neurons. The Journal of physiology 99 18511484
1996 A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression. The Journal of biological chemistry 84 8824288
2013 MicroRNA-1 accelerates the shortening of atrial effective refractory period by regulating KCNE1 and KCNB2 expression: an atrial tachypacing rabbit model. PloS one 70 24386485
2012 The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. The Journal of pharmacology and experimental therapeutics 61 23161216
2010 Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice. The Journal of comparative neurology 36 20853508
1999 Angiotensin II type 1 receptor-mediated inhibition of K+ channel subunit kv2.2 in brain stem and hypothalamic neurons. Circulation research 32 10024310
2013 Protection from noise-induced hearing loss by Kv2.2 potassium currents in the central medial olivocochlear system. The Journal of neuroscience : the official journal of the Society for Neuroscience 30 23699522
2013 Kv2.2: a novel molecular target to study the role of basal forebrain GABAergic neurons in the sleep-wake cycle. Sleep 23 24293758
2013 Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion. The Journal of biological chemistry 22 23788641
2006 Target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (t-SNAREs) differently regulate activation and inactivation gating of Kv2.2 and Kv2.1: Implications on pancreatic islet cell Kv channels. Molecular pharmacology 17 16754785
2018 Fañanas cells-the forgotten cerebellar glia cell type: Immunocytochemistry reveals two potassium channel-related polypeptides, Kv2.2 and Calsenilin (KChIP3) as potential marker proteins. Glia 13 30151916
2021 Protein Kinase C Controls the Excitability of Cortical Pyramidal Neurons by Regulating Kv2.2 Channel Activity. Neuroscience bulletin 11 34542799
2016 The contribution of Kv2.2-mediated currents decreases during the postnatal development of mouse dorsal root ganglion neurons. Physiological reports 10 27033450
2008 Localization of Kv2.2 protein in Xenopus laevis embryos and tadpoles. The Journal of comparative neurology 9 18680201
2002 The Kv2.2 alpha subunit contributes to delayed rectifier K(+) currents in myocytes from rabbit corpus cavernosum. Journal of andrology 9 12399537
2004 Carboxyl tail region of the Kv2.2 subunit mediates novel developmental regulation of channel density. Journal of neurophysiology 8 15306626
2023 Glucocorticoids modulate neural activity via a rapid non-genomic effect on Kv2.2 channels in the central nervous system. Neurobiology of stress 6 38075025
2021 Regulation of K+ Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels. Membranes 6 33803465
2025 The Kv2.2 channel mediates the inhibition of prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells. eLife 3 40028769
2024 The KCNB2 gene and its role in neurodevelopmental disorders: Implications for genetics and therapeutic advances. Clinica chimica acta; international journal of clinical chemistry 2 39577484
2023 EZH2 and matrix co-regulate phenotype and KCNB2 expression in bladder smooth muscle cells. American journal of clinical and experimental urology 1 37645613
2025 Taking the "lazy" way identifies KCNB2 as a regulator of SHH-MB maintenance. Developmental cell 0 40494277

Missed literature

Know a paper Affinage missed for KCNB2? Flag it for the maintainers and the community.

No submissions yet.