Affinage

KCNB2

Potassium voltage-gated channel subfamily B member 2 · UniProt Q92953

Round 2 corrected
Length
911 aa
Mass
102.6 kDa
Annotated
2026-04-28
52 papers in source corpus 20 papers cited in narrative 20 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KCNB2 (Kv2.2) encodes a voltage-gated delayed-rectifier potassium channel that shapes neuronal excitability, endocrine secretion, and cardiac repolarization across diverse tissues. The channel conducts a slowly activating delayed-rectifier K+ current (~15 pS), is enhanced at the plasma membrane by the chaperone subunit mKvβ4 via its C-terminal domain, and is functionally tuned by PKC phosphorylation at S481/S488 (inhibiting current and shifting activation), PKA phosphorylation at S448 (downstream of PGE2-EP2/4 signaling), and non-genomic glucocorticoid-ERK1/2 signaling that increases open probability (PMID:8824288, PMID:34542799, PMID:40028769, PMID:38075025). In the nervous system, Kv2.2 localizes to axon initial segments and supports high-frequency firing in auditory brainstem neurons, with Kv2.2 knockout mice showing broader action potentials, impaired repetitive firing, and increased susceptibility to noise-induced hearing loss; in basal forebrain GABAergic neurons it regulates the sleep–wake cycle, as knockout prolongs consolidated wakefulness (PMID:23699522, PMID:24293758). In pancreatic islets, Kv2.2 is the dominant Kv channel in delta cells where it controls somatostatin secretion, physically interacts with Kv2.1 in beta cells to negatively regulate total Kv current and glucose-stimulated insulin secretion, and mediates PGE2-induced suppression of insulin release through EP2/4-PKA-dependent phosphorylation at S448 (PMID:23161216, PMID:23788641, PMID:40028769).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1996 High

    Identifying how Kv2.2 reaches the cell surface revealed that the accessory subunit mKvβ4 acts as a chaperone that increases Kv2.2 membrane expression up to 6-fold through the channel's C-terminal domain, establishing the first known regulatory mechanism for Kv2.2 surface density.

    Evidence Xenopus oocyte coexpression with chimeric channel analysis

    PMID:8824288

    Open questions at the time
    • Whether mKvβ4 acts on Kv2.2 trafficking in native neurons was not tested
    • Structural basis of C-terminus/mKvβ4 interaction unresolved
  2. 1998 High

    Cloning Kv2.2 from gastrointestinal smooth muscle and reconstituting its current in oocytes defined its biophysical identity as a slowly activating delayed rectifier (~15 pS) with a distinctive pharmacological profile (TEA-sensitive, charybdotoxin-insensitive), placing it as a contributor to delayed-rectifier currents outside the nervous system.

    Evidence Xenopus oocyte expression, single-channel patch clamp, pharmacological profiling

    PMID:9612272

    Open questions at the time
    • Relative contribution versus other Kv channels in native GI smooth muscle not quantified
  3. 1999 High

    Demonstrating that angiotensin II inhibits Kv2.2 current through the AT1 receptor in hypothalamic/brainstem neurons established the first GPCR-to-Kv2.2 signaling axis, linking the channel to cardiovascular autonomic regulation.

    Evidence Xenopus oocyte coexpression of Kv2.2 with AT1R plus native neuron recordings

    PMID:10024310

    Open questions at the time
    • Downstream second messengers mediating AT1R-to-Kv2.2 inhibition not identified
    • Phosphorylation site not mapped
  4. 2004 High

    Chimeric subunit experiments in Xenopus spinal neurons showed that the proximal C-terminal domain of Kv2.2 gates developmental regulation of Kv current density, distinguishing Kv2.2 from Kv2.1 in developmental channel scaling.

    Evidence Chimeric Kv2.1/Kv2.2 overexpression in Xenopus embryos with in vivo voltage clamp

    PMID:15306626

    Open questions at the time
    • Molecular interactors of the proxC domain remain unknown
    • Mammalian validation not performed
  5. 2006 High

    Showing that Kv2.2 interacts with syntaxin 1A but not the syntaxin 1A/SNAP-25 complex (unlike Kv2.1) revealed SNARE-selectivity differences between the two Kv2 paralogs and identified Kv2.2 as the dominant Kv channel in islet alpha and delta cells, predicting roles in glucagon and somatostatin secretion.

    Evidence Oocyte electrophysiology with SNARE coexpression, immunohistochemistry of pancreatic islets

    PMID:16754785

    Open questions at the time
    • Direct functional consequence of syntaxin 1A interaction on Kv2.2 gating in native cells not shown
  6. 2008 High

    Localization of Kv2.2 to the axon initial segment of MNTB auditory neurons and to axonal processes in Xenopus cultured neurons established its subcellular compartmentalization, with modeling showing it aids Nav channel recovery during high-frequency firing.

    Evidence Immunofluorescence with KO-validated antibodies, Hodgkin-Huxley modeling, confocal imaging

    PMID:18511484 PMID:18680201

    Open questions at the time
    • Whether axonal targeting signals reside in Kv2.2 sequence elements was not mapped
  7. 2012 High

    shRNA knockdown of Kv2.2 in islets selectively enhanced somatostatin but not insulin secretion, while a parallel study showed Kv2.2 physically interacts with Kv2.1 in beta cells to negatively regulate total Kv current and GSIS, delineating cell-type-specific roles for the two Kv2 paralogs in islet hormone secretion.

    Evidence Adenovirus-shRNA knockdown, Kv2.1 KO islets with guangxitoxin-1E, co-immunoprecipitation, rescue experiments

    PMID:23161216 PMID:23788641

    Open questions at the time
    • Stoichiometry of Kv2.1/Kv2.2 heteromers in native beta cells undetermined
    • Whether Kv2.2 forms homomeric channels in delta cells versus heteromers not resolved
  8. 2013 High

    Kv2.2 knockout mice demonstrated two major physiological roles: in auditory brainstem neurons, loss of Kv2.2 broadened APs and impaired high-frequency firing, increasing susceptibility to noise-induced hearing loss; in basal forebrain GABAergic neurons, loss prolonged consolidated wakefulness and reduced NREM delta power, establishing Kv2.2 in sleep–wake regulation.

    Evidence Kv2.2 KO mice with viral dominant-negative, ABR recordings, EEG/EMG sleep analysis, c-Fos immunostaining

    PMID:23699522 PMID:24293758

    Open questions at the time
    • Compensatory upregulation of other channels in KO not assessed
    • Circuit-level mechanism linking BF GABAergic activity to wake consolidation not delineated
  9. 2013 High

    Identification of KCNB2 as a direct target of miR-1 in atrial tachypacing-induced remodeling showed that miR-1-mediated downregulation of Kv2.2 shortens the atrial effective refractory period and increases IKs, linking the channel to atrial fibrillation substrate.

    Evidence Luciferase reporter assay, siRNA knockdown, lentiviral miR-1 overexpression, rabbit tachypacing model, patch clamp

    PMID:24386485

    Open questions at the time
    • Whether Kv2.2 restoration prevents AF in vivo not tested
    • Relative contribution of Kv2.2 versus other miR-1 targets to AERP shortening unclear
  10. 2021 High

    Mapping PKC phosphorylation sites to S481 and S488 on Kv2.2 showed that phosphorylation inhibits channel current and shifts activation, reducing firing frequency in cortical pyramidal neurons — the first direct phosphosite identification for Kv2.2 regulation of cortical excitability.

    Evidence Point mutagenesis, phospho-specific antibodies, patch clamp in HEK293 cells and acute cortical slices

    PMID:34542799

    Open questions at the time
    • Upstream activators of PKC targeting Kv2.2 in cortex not identified
    • Whether S481/S488 phosphorylation is constitutive or stimulus-dependent in vivo unknown
  11. 2021 Medium

    Demonstrating that EZH2-mediated H3K27me3 silences KCNB2 at its promoter in obstructed bladder smooth muscle placed Kv2.2 under epigenetic control and showed that EZH2 inhibition restores Kv2.2 expression, linking channel repression to smooth muscle pathology.

    Evidence ChIP-PCR for H3K27me3 at KCNB2 promoter, EZH2 inhibitor, siRNA knockdown, Western blot

    PMID:37645613

    Open questions at the time
    • Whether H3K27me3-mediated regulation of Kv2.2 occurs in other tissues not explored
    • Functional electrophysiological consequence in bladder smooth muscle not recorded
  12. 2023 High

    Glucocorticoids rapidly activate Kv2.2 via membrane-associated glucocorticoid receptors and ERK1/2 signaling (non-genomic), increasing single-channel open probability and suppressing neuronal firing, revealing a stress-hormone pathway that tunes Kv2.2 activity within seconds.

    Evidence Single-channel recording, membrane-impermeable BSA-dexamethasone, ERK inhibitor U0126, cortical and brainstem slices

    PMID:38075025

    Open questions at the time
    • Specific phosphorylation site(s) mediating ERK1/2 activation of Kv2.2 not mapped
    • Whether this pathway operates in non-neuronal tissues unknown
  13. 2025 High

    PGE2 was shown to inhibit Kv2.2 through EP2/4-PKA-dependent phosphorylation at S448, suppressing beta-cell firing and GSIS; Kcnb2 KO mice were resistant to PGE2-induced glucose intolerance, establishing the complete receptor-to-channel signaling axis for prostaglandin-mediated insulin secretion impairment.

    Evidence S448 point mutagenesis, EP receptor agonists/antagonists, Kcnb2 KO mice, glucose tolerance tests, islet perifusion, patch clamp

    PMID:40028769

    Open questions at the time
    • Whether S448 phosphorylation intersects with PKC-mediated S481/S488 phosphorylation not tested
    • Role of Kv2.2 in inflammatory settings where PGE2 is elevated not examined in vivo

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major open questions include the high-resolution structure of Kv2.2, the full phosphorylation landscape integrating PKA, PKC, and ERK inputs, the stoichiometry and functional properties of native Kv2.1/Kv2.2 and Kv2.2/Kv6.4 heteromers, and the mechanisms governing Kv2.2's axonal versus somatic targeting in different neuronal populations.
  • No high-resolution structure of Kv2.2 available
  • Phosphosite cross-talk between PKA, PKC, and ERK not mapped
  • Native heteromer stoichiometry unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 7
Localization
GO:0005886 plasma membrane 5 GO:0005783 endoplasmic reticulum 1 GO:0005829 cytosol 1
Pathway
R-HSA-112316 Neuronal System 6 R-HSA-382551 Transport of small molecules 5 R-HSA-162582 Signal Transduction 4
Partners
KCNAB3KCNB1KCNG4STX1A

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 A novel beta subunit, mKvbeta4, specifically associates with Kv2.2 (CDRK) to enhance its expression level up to 6-fold without changing elementary conductance or kinetics. Chimeric channel experiments showed the C-terminal end of Kv2.2 is essential for mKvbeta4 sensitivity. mKvbeta4 acts as a chaperone-like factor to permit integration of more Kv2.2 channels at the plasma membrane, and does not affect the closely related Kv2.1. Xenopus oocyte coexpression, chimeric channel analysis, co-localization of transcripts The Journal of biological chemistry High 8824288
1998 Kv2.2 was isolated from human and canine gastrointestinal smooth muscle and shown to mediate a slowly activating delayed rectifier K+ current (15 pS single channels) when expressed in Xenopus oocytes, inhibited by TEA (IC50 2.6 mM), 4-AP (IC50 1.5 mM), and quinine (IC50 13.7 µM), and insensitive to charybdotoxin, establishing it as a component of delayed rectifier current in GI smooth muscle. Xenopus oocyte expression, single-channel patch clamp, pharmacological characterization, RT-PCR The American journal of physiology High 9612272
1999 Angiotensin II inhibits Kv2.2 current via AT1 receptor signaling in hypothalamic/brainstem neurons. Coexpression of Kv2.2 with AT1 receptor in Xenopus oocytes confirmed AT1 receptor-mediated inhibition of Kv2.2 current, contributing to increased neuronal firing rate. Xenopus oocyte coexpression, whole-cell patch clamp, pharmacological dissection, RT-PCR, Western blot Circulation research High 10024310
2004 The proximal C-terminal domain (proxC) of Kv2.2 mediates developmental and subunit-specific regulation of voltage-gated K+ current density in Xenopus spinal neurons. Chimeric Kv2.1/Kv2.2 subunits showed that loss of proxC allows Kv2.2-like subunits to increase current density in mature neurons, identifying a novel function for this domain in developmental regulation of channel expression. Chimeric channel overexpression in Xenopus embryos, two-electrode voltage clamp, in vivo current-density measurements Journal of neurophysiology High 15306626
2006 Kv2.2 interacts specifically with syntaxin 1A but not with the syntaxin 1A/SNAP-25 complex, in contrast to Kv2.1 which interacts with both. This differential SNARE regulation is attributable to differences in the C-termini of Kv2.1 and Kv2.2. Kv2.2 is the dominant Kv channel in pancreatic alpha and delta cells, where it would regulate glucagon and somatostatin secretion. Two-electrode voltage clamp in Xenopus oocytes, immunohistochemistry, comparative electrophysiology Molecular pharmacology High 16754785
2008 Kv2.2 is highly expressed at axon initial segments of MNTB neurons, where Hodgkin-Huxley modelling and current-clamp recordings showed it plays a minor role during single APs but assists recovery of Nav channels from inactivation by hyperpolarizing interspike potentials during repetitive high-frequency AP firing. Quantitative RT-PCR, immunofluorescence/confocal imaging, Western blot with Kv2.2 KO control, Hodgkin-Huxley modelling, whole-cell current clamp The Journal of physiology High 18511484
2008 In Xenopus laevis neurons, Kv2.2 protein localizes to long axonal-like processes (distinct from Kv2.1 which is somatodendritic) and co-localizes intracellularly with alpha-tubulin in association with neuronal tracts, establishing a subcellular distribution consistent with roles in axonal signaling. Immunodetection with Kv2.2-specific antibody (validated against Kv2.1), confocal imaging of cultured neurons and tissue sections The Journal of comparative neurology Medium 18680201
2010 Kv2.2 is abundantly expressed in a large subpopulation (~60%) of GABAergic neurons in the magnocellular preoptic nucleus and horizontal limb of the diagonal band of Broca of the basal forebrain, identified using GFP-knockin GABAergic reporter mice and specific immunolabeling. Immunolabeling, knockin GFP reporter mice (GABAergic neurons), confocal imaging The Journal of comparative neurology Medium 20853508
2012 Kv2.2 specifically regulates somatostatin secretion in pancreatic delta cells, while Kv2.1 regulates insulin secretion in beta cells. adenovirus-shRNA knockdown of Kv2.2 in mouse islets selectively enhanced somatostatin but not insulin secretion, and pharmacological inhibition of Kv2 channels (guangxitoxin-1E) enhanced somatostatin release in Kv2.1-/- islets. Adenovirus-shRNA knockdown in mouse islets, selective pharmacological inhibitors, Kv2.1 KO mice, islet perifusion The Journal of pharmacology and experimental therapeutics High 23161216
2013 In VNTB brainstem neurons of the medial olivocochlear system, Kv2.2 maintains short action potentials and enables high-frequency firing. Dominant-negative Kv2.2 viral gene transfer and Kv2.2 KO mice both showed increased AP half-width and reduced repetitive firing. In vivo, Kv2.2 KO mice were more susceptible to noise-induced hearing loss, demonstrating that Kv2.2 is required for efferent auditory protection. Viral dominant-negative gene transfer, Kv2.2 KO mice, whole-cell patch clamp, in vivo auditory brainstem response recordings The Journal of neuroscience High 23699522
2013 miR-1 directly targets KCNB2 (confirmed by luciferase assay) and downregulates its expression in atrial tachypacing, contributing to shortening of the atrial effective refractory period. siRNA knockdown of KCNB2 alone was sufficient to shorten AERP and increase IKs in atrial cells. Luciferase reporter assay, siRNA knockdown, lentiviral miR-1 overexpression, whole-cell patch clamp, in vivo rabbit model PloS one High 24386485
2013 Pyruvate-isocitrate cycling (via ICDc) regulates Kv2.2 expression in pancreatic beta-cells. Kv2.2 acts as a negative regulator of total Kv channel activity through physical interaction with Kv2.1 (demonstrated by immunoprecipitation); co-overexpression of Kv2.1 and Kv2.2 reduced outward K+ current compared with Kv2.1 alone. ICDc knockdown phenocopied Kv2.2 knockdown in impairing GSIS, and was rescued by Kv2.2 re-expression. siRNA knockdown, immunoprecipitation (Kv2.1-Kv2.2 interaction), selective Kv2.1 inhibitor stromatoxin-1, rescue by re-expression, GSIS assays The Journal of biological chemistry High 23788641
2013 Kv2.2-expressing basal forebrain GABAergic neurons regulate the sleep-wake cycle. Kv2.2 KO mice showed longer consolidated wake bouts, decreased delta-frequency EEG during NREM sleep, and augmented c-Fos in BF GABAergic neurons, indicating Kv2.2-expressing neurons are active during wakefulness and their dysfunction prolongs waking. EEG/EMG recordings, Kv2.2 KO mice, c-Fos immunostaining, sleep deprivation protocol Sleep High 24293758
2018 Kv2.2 is expressed in Fañanas cells (a distinct astrocytic subtype) of the cerebellar Purkinje cell layer, identified as a marker protein using antibody-based immunocytochemistry. Immunocytochemistry with multiple labeling methods, confocal imaging Glia Low 30151916
2021 PKC phosphorylates Kv2.2 at S481 and S488, inhibiting Kv2.2 currents and shifting steady-state activation, thereby reducing action potential firing frequency in cortical layer II pyramidal neurons. Point mutations at these residues abolished PKC-dependent modulation. PKC activation in HEK293 cells and cortical slices, point mutagenesis, phospho-specific antibodies, whole-cell patch clamp, current clamp in brain slices Neuroscience bulletin High 34542799
2021 An inter-subunit hydrogen bond formed by W366 and Y376 (Kv2.1 numbering; conserved in Kv2.2) is essential for K+ conductance; mutations breaking this bond result in complete loss of K+ conductance in Kv2.1, Kv2.2, and Kv1.2 channels, distinct from the W434-D447/T439-Y445 bonds controlling slow inactivation in Shaker. Point mutagenesis, patch-clamp recording in mammalian expression system Membranes Medium 33803465
2021 EZH2-mediated H3K27me3 represses KCNB2 expression in bladder smooth muscle cells during obstruction; EZH2 inhibition restored Kv2.2 expression and partially restored smooth muscle cell phenotype, placing Kv2.2 downstream of EZH2 epigenetic regulation in a disease context. ChIP/PCR for H3K27me3 at KCNB2 promoter, EZH2 inhibitor (UNC1999), siRNA against KCNB2, Western blot, immunostaining, RT-qPCR American journal of clinical and experimental urology Medium 37645613
2023 Glucocorticoids (cortisol) rapidly activate Kv2.2 channels via membrane-associated glucocorticoid receptors and ERK1/2 kinase signaling (non-genomic), increasing single-channel open probability. This suppresses action potential firing frequency in cortical pyramidal neurons and calyx of Held synapses and increases activity-dependent synaptic depression. BSA-conjugated dexamethasone (membrane-impermeable) mimicked the effect; U0126 (ERK inhibitor) blocked it. Single-channel recording, HEK293 cell overexpression, acute cortical and brainstem slices, membrane-impermeable agonist, ERK inhibitor, patch clamp Neurobiology of stress High 38075025
2025 PGE2 inhibits Kv2.2 channels via PKA-dependent phosphorylation at S448 through EP2/4 receptors, reducing action potential firing in pancreatic beta-cells and impairing glucose-stimulated insulin secretion (GSIS). Kcnb2 knockout mice showed reduced GSIS and were resistant to PGE2-induced glucose intolerance, confirming the EP2/4-Kv2.2 pathway as the mechanistic basis for PGE2 inhibition of GSIS. Point mutagenesis (S448), HEK293T overexpression, EP receptor agonists/antagonists, siRNA knockdown in INS-1 cells, Kcnb2 KO mice, glucose tolerance test, islet perifusion, patch clamp eLife High 40028769
2025 Kv2.2 subunits co-cluster with Kv2.1 and Kv6.4 at ER-plasma membrane junctions beneath C-bouton synapses in spinal motor neurons. Clustering of Kv6.4 (and AMIGO-1) was severely reduced in Kv2.1 KO and moderately reduced in Kv2.2 KO mice, indicating Kv6.4 localization depends on co-assembly with Kv2 subunits. In Kv2.1 S590A mice (unable to bind ER VAP proteins), Kv2.1 and Kv6.4 clustering at ER-PM junctions was severely reduced. Immunofluorescence co-localization, Kv2.1 KO and Kv2.2 KO mice, Kv2.1 S590A knock-in mice, confocal imaging bioRxivpreprint Medium bio_10.1101_2025.06.04.657913

Source papers

Stage 0 corpus · 52 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2005 International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacological reviews 721 16382104
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2008 Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Human molecular genetics 366 19010793
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2018 An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nature communications 201 29568061
2019 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Nature cell biology 137 31871319
2012 A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. PLoS genetics 117 22412388
2020 FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts. The EMBO journal 113 33124732
1996 Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. The EMBO journal 109 8670833
2010 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Molecular medicine (Cambridge, Mass.) 108 20379614
2008 Initial segment Kv2.2 channels mediate a slow delayed rectifier and maintain high frequency action potential firing in medial nucleus of the trapezoid body neurons. The Journal of physiology 99 18511484
2021 SARS-CoV-2-host proteome interactions for antiviral drug discovery. Molecular systems biology 86 34709727
1996 A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression. The Journal of biological chemistry 84 8824288
2004 Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes 83 14988243
2007 Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. BMC medical genetics 82 17903301
2019 Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons. eLife 81 31663850
2010 Common genetic variation and performance on standardized cognitive tests. European journal of human genetics : EJHG 78 20125193
2008 A high-density association screen of 155 ion transport genes for involvement with common migraine. Human molecular genetics 72 18676988
2013 MicroRNA-1 accelerates the shortening of atrial effective refractory period by regulating KCNE1 and KCNB2 expression: an atrial tachypacing rabbit model. PloS one 68 24386485
2007 Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Proteomics 66 17474147
2012 The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. The Journal of pharmacology and experimental therapeutics 60 23161216
2014 Disease-targeted sequencing of ion channel genes identifies de novo mutations in patients with non-familial Brugada syndrome. Scientific reports 56 25339316
1998 Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. The American journal of physiology 46 9612272
2023 Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders. Cell genomics 38 36950384
2017 Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction. Diabetes 38 28607108
2021 RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy. eLife 36 34702444
2013 Genome-wide association studies of maximum number of drinks. Journal of psychiatric research 36 23953852
2010 Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice. The Journal of comparative neurology 36 20853508
1999 Angiotensin II type 1 receptor-mediated inhibition of K+ channel subunit kv2.2 in brain stem and hypothalamic neurons. Circulation research 32 10024310
2013 Protection from noise-induced hearing loss by Kv2.2 potassium currents in the central medial olivocochlear system. The Journal of neuroscience : the official journal of the Society for Neuroscience 30 23699522
2016 Pore size matters for potassium channel conductance. The Journal of general physiology 29 27619418
2020 SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Journal of immunology (Baltimore, Md. : 1950) 27 32393512
2013 Kv2.2: a novel molecular target to study the role of basal forebrain GABAergic neurons in the sleep-wake cycle. Sleep 23 24293758
2013 Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion. The Journal of biological chemistry 21 23788641
2008 Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. The Journal of biological chemistry 18 19074135
2020 PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential. iScience 17 32062451
2012 Expression and function of K(V)2-containing channels in human urinary bladder smooth muscle. American journal of physiology. Cell physiology 17 22422395
2006 Target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (t-SNAREs) differently regulate activation and inactivation gating of Kv2.2 and Kv2.1: Implications on pancreatic islet cell Kv channels. Molecular pharmacology 16 16754785
2018 Fañanas cells-the forgotten cerebellar glia cell type: Immunocytochemistry reveals two potassium channel-related polypeptides, Kv2.2 and Calsenilin (KChIP3) as potential marker proteins. Glia 12 30151916
2021 Protein Kinase C Controls the Excitability of Cortical Pyramidal Neurons by Regulating Kv2.2 Channel Activity. Neuroscience bulletin 10 34542799
2016 The contribution of Kv2.2-mediated currents decreases during the postnatal development of mouse dorsal root ganglion neurons. Physiological reports 10 27033450
2008 Localization of Kv2.2 protein in Xenopus laevis embryos and tadpoles. The Journal of comparative neurology 9 18680201
2002 The Kv2.2 alpha subunit contributes to delayed rectifier K(+) currents in myocytes from rabbit corpus cavernosum. Journal of andrology 9 12399537
2004 Carboxyl tail region of the Kv2.2 subunit mediates novel developmental regulation of channel density. Journal of neurophysiology 8 15306626
2021 Regulation of K+ Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels. Membranes 6 33803465
2023 Glucocorticoids modulate neural activity via a rapid non-genomic effect on Kv2.2 channels in the central nervous system. Neurobiology of stress 5 38075025
2025 The Kv2.2 channel mediates the inhibition of prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells. eLife 2 40028769
2024 The KCNB2 gene and its role in neurodevelopmental disorders: Implications for genetics and therapeutic advances. Clinica chimica acta; international journal of clinical chemistry 2 39577484
2023 EZH2 and matrix co-regulate phenotype and KCNB2 expression in bladder smooth muscle cells. American journal of clinical and experimental urology 1 37645613
2025 Taking the "lazy" way identifies KCNB2 as a regulator of SHH-MB maintenance. Developmental cell 0 40494277