Affinage

KAT5

Histone acetyltransferase KAT5 · UniProt Q92993

Length
513 aa
Mass
58.6 kDa
Annotated
2026-04-28
100 papers in source corpus 45 papers cited in narrative 44 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KAT5 (Tip60) is a MYST-family lysine acetyltransferase that functions as the catalytic subunit of the NuA4/TIP60 complex to acetylate histones H4, H2A, and H2A.Z, thereby regulating transcription, DNA double-strand break repair, autophagy, cell fate specification, and chromosome segregation. KAT5 catalyzes acetylation via a ping-pong mechanism involving a self-acetylated cysteine intermediate, and its activity is stimulated by CDK9-mediated phosphorylation at Ser90 (enabling chromatin association) followed by GSK3-mediated phosphorylation at Ser86; the enzyme also possesses crotonyltransferase activity toward histones and EB1 (PMID:12368900, PMID:22539723, PMID:29335245, PMID:34608293). Beyond histones, KAT5 acetylates ATM (activating the DNA damage kinase through chromodomain engagement of H3K9me3), p53 at K120 (directing apoptosis over growth arrest), Aurora B at K215 (protecting activation-loop phosphorylation during mitosis), ULK1 (stimulating autophagy), cGAS (enhancing innate DNA sensing), and lipin 1 (promoting ER translocation for triacylglycerol synthesis) (PMID:17189186, PMID:20160506, PMID:26829474, PMID:32817552, PMID:29765047). De novo heterozygous missense variants in KAT5 that abolish acetyltransferase activity cause a neurodevelopmental syndrome (PMID:32822602).

Mechanistic history

Synthesis pass · year-by-year structured walk · 22 steps
  1. 2001 Medium

    Identification of a KAT5 splice variant (PLIP) interacting with cPLA2 established that Tip60 engages non-histone nuclear partners and can modulate lipid signaling and apoptosis.

    Evidence Co-IP plus functional assays in cPLA2+/+ vs. cPLA2−/− mesangial cells

    PMID:11416127

    Open questions at the time
    • Direct acetyltransferase activity toward cPLA2 not demonstrated
    • Physiological relevance of PLIP splice variant unclear
  2. 2002 High

    Demonstration that yeast Esa1 is recruited to DNA double-strand breaks and required for repair via NHEJ and replication-coupled pathways established KAT5/NuA4 as a direct chromatin modifier at damage sites, linking histone H4 acetylation to the DNA damage response.

    Evidence ChIP at induced DSBs, in vitro HAT assays with nucleosomal substrates, and genetic epistasis in S. cerevisiae

    PMID:12353039

    Open questions at the time
    • Human Tip60 recruitment mechanism to DSBs not yet shown at this stage
    • Identity of critical acetylation sites on H4 at breaks not resolved
  3. 2002 High

    Crystal structure of Esa1 revealed a ping-pong catalytic mechanism via a cysteine-acetyl intermediate, distinguishing the MYST family from GCN5/PCAF-type HATs and defining the enzymatic chemistry of KAT5.

    Evidence X-ray crystallography of Esa1-CoA complex with active-site mutagenesis and in vitro acetylation assays

    PMID:12368900

    Open questions at the time
    • Whether human KAT5 uses identical mechanism assumed but not structurally confirmed at this point
  4. 2003 High

    Reconstitution of the piccolo NuA4 subcomplex (Esa1-Epl1-Yng2) showed that Epl1 bridges and stimulates Esa1 catalytic activity and confers chromatin substrate preference, defining the minimal catalytic module within NuA4.

    Evidence Recombinant complex reconstitution, in vitro HAT assays comparing chromatin vs. free histones, genetic depletion

    PMID:12782659

    Open questions at the time
    • How piccolo NuA4 is integrated into the full NuA4 complex was unresolved
    • Human piccolo equivalent not yet characterized
  5. 2006 High

    Direct acetylation of p53 at K120 by KAT5 was shown to selectively drive apoptosis rather than growth arrest, establishing KAT5 as a cell-fate switch acting through non-histone substrate acetylation.

    Evidence In vitro acetyltransferase assay, K120R mutagenesis, apoptosis vs. growth-arrest readouts

    PMID:16601686 PMID:17189186

    Open questions at the time
    • How Tip60 is selectively activated toward p53 vs. histones after damage was unclear
    • In vivo physiological confirmation in animal models not yet done
  6. 2008 Medium

    The Esa1 chromodomain was found to adopt a knotted tudor fold that binds RNA, and RNA-binding mutations were lethal in yeast, revealing an unexpected essential RNA-binding function for KAT5.

    Evidence NMR solution structure, RNA-binding assays, systematic alanine-scanning mutagenesis with yeast viability readout

    PMID:18407291

    Open questions at the time
    • Identity of physiological RNA ligands unknown
    • Whether human KAT5 chromodomain retains RNA binding not tested
    • Single lab finding
  7. 2008 Medium

    ATF2/Cul3-mediated ubiquitin-dependent degradation of TIP60 was identified as a basal mechanism restraining HAT activity, with ionizing radiation relieving this degradation to enable ATM activation — establishing that TIP60 protein stability is a regulatory node in the DDR.

    Evidence siRNA, Co-IP, protein half-life measurements, ATM kinase assays

    PMID:18397884

    Open questions at the time
    • Direct ubiquitination sites on TIP60 not mapped
    • Cul3 adaptor protein not identified
  8. 2009 Medium

    Sirt1 was shown to deacetylate Tip60 autoacetylation and promote its proteasomal degradation, while HDAC3 deacetylates Tip60 but stabilizes it, revealing opposing deacetylase-dependent mechanisms that tune Tip60 levels and DNA damage-induced apoptosis.

    Evidence Co-IP, in vitro deacetylation assays, ubiquitination and half-life measurements, DNA repair foci analysis

    PMID:19895790 PMID:25301942

    Open questions at the time
    • How Sirt1 vs. HDAC3 are differentially recruited to Tip60 is unknown
    • In vivo validation of opposing stability regulation absent
  9. 2010 High

    The mechanism of ATM activation by KAT5 was elucidated: Tip60's chromodomain binds H3K9me3 at DSBs, stimulating its acetyltransferase activity and leading to direct acetylation and activation of the ATM kinase, with FOXO3a serving as a bridging factor and NOTCH1 as a competitive inhibitor.

    Evidence Chromodomain-H3K9me3 binding assays, ATM kinase activation assays, competition binding assays, Co-IP

    PMID:20160506 PMID:27524627

    Open questions at the time
    • Specific acetylation site(s) on ATM responsible for activation not fully resolved
    • Structural basis of Tip60-ATM interaction unknown
  10. 2012 High

    GSK3 phosphorylation of TIP60 at Ser86 was shown to activate its acetyltransferase activity toward ULK1, directly linking growth-factor deprivation and ER stress to autophagy induction via the GSK3–TIP60–ULK1 axis.

    Evidence In vitro kinase/acetyltransferase assays, Tip60 S86A knock-in mice, rescue in ULK1−/− MEFs, ER stress autophagy flux assays

    PMID:22539723 PMID:28032867

    Open questions at the time
    • Specific ULK1 acetylation sites driving autophagy not fully mapped
    • Whether other kinases contribute to Ser86 phosphorylation under different stresses unclear
  11. 2016 High

    CDK1-cyclin B phosphorylation of TIP60 at Ser90 was shown to trigger acetylation of Aurora B at K215, protecting its activation loop from PP2A dephosphorylation and ensuring accurate chromosome segregation — establishing a mitotic acetylation checkpoint role for KAT5.

    Evidence In vitro kinase/acetyltransferase assays, phospho-mimetic and acetylation-defective mutants, live-cell imaging

    PMID:26829474

    Open questions at the time
    • Whether other mitotic substrates are similarly regulated by phospho-TIP60 is unknown
  12. 2017 High

    KAT5 acetyltransferase activity was shown to be dispensable for ESC self-renewal but essential for mesoderm/endoderm differentiation and H2A.Z acetylation at lineage genes, separating catalytic from scaffold functions of KAT5 in stem cell biology.

    Evidence Catalytic-dead Tip60 mutant ESCs, gene expression profiling, chromatin accessibility, mouse embryo analysis

    PMID:28445719

    Open questions at the time
    • Non-catalytic molecular function in ESC self-renewal is undefined
    • Whether acetyltransferase-independent function involves complex scaffolding is speculative
  13. 2018 Medium

    CDK9 was identified as the kinase phosphorylating TIP60 at Ser90 that primes subsequent GSK3-mediated Ser86 phosphorylation, with Ser90 phosphorylation required for TIP60 chromatin association and H4 acetylation at target genes such as MYC.

    Evidence Kinase assays, Co-IP with chromatin components, ChIP at MYC locus, proliferation assays with phospho-deficient mutants

    PMID:29335245

    Open questions at the time
    • Whether CDK9 phosphorylation is cell-cycle regulated is unresolved
    • Generality of CDK9 priming across TIP60 substrates untested
  14. 2018 High

    Cryo-EM structures of the yeast NuA4 complex revealed that Tra1 and Eaf1 scaffold the multi-module architecture, with Eaf1 SANT domain bridging Tra1 and the actin/Arp4 module associating peripherally — providing the first structural framework for how the acetyltransferase module is organized within the holo-complex.

    Evidence Cryo-EM at 4.7–7.6 Å resolution of S. cerevisiae NuA4 assemblies

    PMID:29559617

    Open questions at the time
    • Human complex architecture not yet solved
    • Nucleosome engagement mechanism not captured
  15. 2018 High

    TIP60 acetylation of lipin 1 was shown to promote its ER translocation for triacylglycerol synthesis, with GSK3-phosphorylated Tip60 required in vivo — Tip60(SA/SA) knock-in mice had reduced body fat and impaired milk TAG, establishing a metabolic role for the GSK3–TIP60 axis.

    Evidence Knock-in mouse model, in vitro acetyltransferase assay, subcellular fractionation, Sirt1 deacetylation assay, yeast genetic validation

    PMID:29765047

    Open questions at the time
    • Specific lipin 1 acetylation sites and structural consequences not fully characterized
  16. 2019 High

    KAT5 acetylation of MARCKS at K165 was found to be prerequisite for PKC-mediated phosphorylation, with SIRT2 opposing this modification; disruption of this axis under diabetic conditions causes mitochondrial dysfunction and neural tube defects.

    Evidence In vitro acetyltransferase assay, MARCKS knock-in, SIRT2 rescue in developing neuroepithelium

    PMID:30655546

    Open questions at the time
    • Whether KAT5–MARCKS axis operates in non-diabetic neural tube closure is untested
  17. 2019 Medium

    Esa1/piccolo NuA4 was shown to be a bona fide histone crotonyltransferase, and structure-guided mutagenesis revealed that a Tudor-domain loop and Epl1 basic region are required for nucleosomal acetylation post-binding, refining understanding of substrate engagement.

    Evidence In vitro crotonyltransferase assay, mass spectrometry, mutagenesis with crosslinking/proximity assays

    PMID:23109429 PMID:31699900

    Open questions at the time
    • Physiological relevance of histone crotonylation vs. acetylation by KAT5 unclear
    • Whether human TIP60 complex has equivalent crotonyltransferase activity untested
  18. 2020 High

    KAT5 acetylation of cGAS N-terminal lysines was shown to enhance DNA binding and innate immune signaling, with Kat5-inactivated mice exhibiting increased susceptibility to DNA virus infection — extending KAT5's non-histone substrate repertoire to innate immunity.

    Evidence In vitro acetyltransferase assay, KO studies, DNA-binding assays, in vivo mouse infection model

    PMID:32817552

    Open questions at the time
    • Specific cGAS lysines acetylated and their individual contributions not fully dissected
  19. 2020 High

    De novo heterozygous KAT5 missense variants at the chromodomain and acetyl-CoA binding site were identified as causative for a neurodevelopmental syndrome, with purified mutant complexes failing to acetylate chromatin — directly linking loss of KAT5 acetyltransferase activity to human disease.

    Evidence In vitro HAT assay with purified variant NuA4/TIP60 complexes, transcriptomics of patient fibroblasts, three independent patients

    PMID:32822602

    Open questions at the time
    • Neuropathological mechanism downstream of lost acetylation not defined
    • Whether haploinsufficiency or dominant-negative effect is primary is unresolved
  20. 2021 High

    TIP60 was shown to crotonylate EB1 at K66, linking microtubule plus-end dynamics to cortical force generation for spindle positioning during mitosis — extending KAT5's acyltransferase activities to non-histone cytoskeletal regulators.

    Evidence In vitro crotonylation assay, genetically encoded crotonylated EB1, live-cell imaging of spindle orientation

    PMID:34608293

    Open questions at the time
    • Physiological crotonyl-CoA concentrations in mitotic cells not assessed
    • Whether crotonylation occurs in the NuA4 complex context unknown
  21. 2022 High

    KAT5-dependent acetylation of H2A.Z was shown to be required for H3K4me3 deposition and activation of bivalent chromatin-marked genes during neuronal differentiation, defining the epigenetic mechanism through which KAT5 specifies neuronal fate.

    Evidence Tip60 KO, H2A.Z acetylation-defective mutants, ChIP-seq for H3K4me3, direct neuronal conversion assays

    PMID:36417913

    Open questions at the time
    • Whether KAT5 directly acetylates H2A.Z or requires additional factors in this context unclear
    • Mechanism linking acH2A.Z to H3K4me3 deposition not molecularly defined
  22. 2024 High

    Cryo-EM structures of the human NuA4/TIP60 complex revealed EP400 as the central scaffold integrating motor, ARP, and TRRAP modules in a three-lobed architecture; TRRAP loss caused genomic redistribution of H2A.Z and its acetylation, establishing TRRAP as the chromatin-targeting subunit.

    Evidence Cryo-EM at 3.2 Å resolution of human TIP60-EP400 complex, TRRAP KO with ChIP-seq, histone exchange assays

    PMID:39088653 PMID:39154037 PMID:39260417

    Open questions at the time
    • Mechanism of nucleosome engagement and histone exchange by the intact complex not yet captured structurally
    • How TIP60 catalytic activity is regulated within the holo-complex architecture is unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major open questions include: how the full human NuA4/TIP60 complex engages and remodels nucleosomes at atomic resolution; what distinguishes KAT5's selection among its many non-histone substrates in different signaling contexts; and what the neuropathological mechanism is downstream of disease-causing KAT5 variants.
  • No structure of TIP60 complex engaged with a nucleosome substrate
  • Substrate selection mechanism across diverse non-histone targets unresolved
  • Neural circuit or cell-type basis of KAT5 neurodevelopmental syndrome undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 9 GO:0016740 transferase activity 8 GO:0042393 histone binding 4 GO:0140110 transcription regulator activity 4 GO:0003723 RNA binding 1
Localization
GO:0005634 nucleus 5 GO:0005694 chromosome 5
Pathway
R-HSA-4839726 Chromatin organization 6 R-HSA-73894 DNA Repair 5 R-HSA-74160 Gene expression (Transcription) 5 R-HSA-1266738 Developmental Biology 3 R-HSA-1640170 Cell Cycle 2 R-HSA-5357801 Programmed Cell Death 2 R-HSA-9612973 Autophagy 2 R-HSA-1430728 Metabolism 1 R-HSA-1643685 Disease 1 R-HSA-168256 Immune System 1
Partners
ACTL6AATMEP400EPC1FANCD2RUVBL1TRRAPULK1
Complex memberships
NuA4/TIP60 complexpiccolo NuA4 (Esa1-Epl1-Yng2)

Evidence

Reading pass · 44 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 Tip60 (KAT5) directly acetylates p53 at lysine 120 (K120) within the DNA-binding domain; this modification is specifically required for p53-dependent apoptosis but dispensable for p53-mediated growth arrest, demonstrating that Tip60-dependent acetylation of p53 at K120 modulates cell fate decisions between arrest and apoptosis. In vitro acetyltransferase assay, site-directed mutagenesis (K120R), reporter assays, cell-based apoptosis and growth-arrest readouts Molecular cell High 17189186
2002 Yeast Esa1 (ortholog of human KAT5/Tip60) is required for histone H4 acetylation and DNA double-strand break repair via both nonhomologous end joining and replication-coupled repair; Arp4 (part of the Esa1-containing NuA4 HAT complex) is recruited specifically to DSBs in vivo, and the purified Esa1-Arp4 HAT complex preferentially acetylates nucleosomes near break sites. Genetic mutant analysis, in vitro HAT assay with nucleosomal arrays, ChIP at induced DSBs Nature High 12353039
2002 Yeast Esa1 (KAT5 ortholog) catalyzes histone acetylation via a self-acetylated cysteine intermediate (ping-pong mechanism), distinct from the direct nucleophilic attack mechanism of GCN5/PCAF; the catalytic cysteine is strictly conserved across the MYST subfamily, suggesting a common MYST catalytic mechanism. Crystal structure of Esa1-CoA complex, active-site mutagenesis, in vitro acetylation assays Nature structural biology High 12368900
2012 GSK3 phosphorylates TIP60 at Ser86 upon growth factor deprivation, activating TIP60's acetyltransferase activity; activated TIP60 then directly acetylates ULK1 to stimulate autophagy. A TIP60(S86A) phosphorylation-defective mutant cannot undergo serum-deprivation-induced autophagy, and an acetylation-defective ULK1 mutant fails to rescue autophagy in ULK1-/- MEFs. In vitro kinase/acetyltransferase assays, phosphorylation-deficient knock-in mice, rescue experiments in ULK1-/- MEFs Science High 22539723
2016 CDK1-cyclin B phosphorylates TIP60 at Ser90, which triggers TIP60-dependent acetylation of Aurora B at Lys215 during mitosis; this acetylation protects Aurora B's activation loop from PP2A-mediated dephosphorylation, ensuring accurate chromosome segregation. In vitro kinase/acetyltransferase assays, phospho-mimetic and acetylation-defective mutants, live-cell imaging of chromosome segregation Nature chemical biology High 26829474
2021 TIP60 directly crotonylates EB1 at Lys66; this modification forms a dynamic link between astral microtubule attachment to the lateral cell cortex (via NuMA-LGN) and accurate spindle positioning during mitosis. Cells expressing genetically encoded acetylation-defective EB1 showed spindle misorientation. In vitro crotonylation assay, genetically encoded crotonylated EB1, live-cell imaging of chromosome movements Nature chemical biology High 34608293
2018 The NuA4/TIP60 complex architecture was resolved by cryo-EM at 4.7 Å (TEEAA assembly) and 7.6 Å (with piccolo); Tra1 and Eaf1 form the assembly scaffold, Eaf1 SANT domain binds Tra1 LBE and FATC domains by ionic interactions, and actin/Arp4 peripherally associate with Eaf1 HSA domain. Cryo-electron microscopy structure determination of S. cerevisiae NuA4 assemblies Nature communications High 29559617
2024 Cryo-EM structures of the human NuA4/TIP60 complex show EP400 as the scaffold integrating motor, ARP, and TRRAP modules; TRRAP loss leads to mislocalization of NuA4/TIP60 and redistribution of H2A.Z and its acetylation across the genome, demonstrating TRRAP's role in chromatin targeting. Cryo-EM structure determination, TRRAP knockout with ChIP-seq for H2A.Z and acetyl-H2A.Z Science High 39088653
2024 Cryo-EM structure of endogenous human TIP60-C (TIP60-EP400 complex) reveals a three-lobed architecture; EP400 contains the ATPase motor, traverses the SWR1-like/NuA4-like junction twice, and TRRAP is flexibly tethered to NuA4L with a fixed actin module, diverging from yeast SWR1. Cryo-EM structure of endogenous human TIP60-EP400 complex, functional histone exchange activity assays Nature High 39260417
2024 Cryo-EM structures of human TIP60 core subcomplex show EP400 as a backbone integrating motor, ARP, and TRRAP modules; RUVBL1-RUVBL2 hexamer serves as a rigid core; ACTL6A-ACTB heterodimer plus extra ACTL6A make hydrophobic contacts with EP400 HSA helix, and the nucleosome is found in an unengaged state between the core and TRRAP module. Cryo-EM at 3.2-Å resolution of human TIP60 complex Nature communications High 39154037
2003 Yeast Epl1 (ortholog of human EPC1/EPC2), a NuA4 subunit, forms the piccolo NuA4 complex (Esa1-Epl1-Yng2) that preferentially acetylates chromatin over free histones; Epl1 N-terminal domain bridges Esa1 and Yng2 together, directly stimulating Esa1 catalytic activity. Complex reconstitution, in vitro HAT assays with chromatin vs. free histones, genetic depletion with cell-cycle phenotype analysis Genes & development High 12782659
2020 KAT5 acetylates cGAS at multiple lysine residues in its N-terminal domain, promoting cGAS's DNA-binding ability and enhancing innate immune signaling in response to cytosolic DNA; Kat5-inactivated mice showed lower serum cytokines, higher viral titers, and increased susceptibility to DNA-virus-induced death. Overexpression and KO studies, in vitro acetyltransferase assay, DNA-binding assays, in vivo mouse infection model PNAS High 32817552
2010 Tip60 (KAT5) binds ATM and activates its kinase activity; Tip60's chromodomain interacts with histone H3 trimethylated at Lys9 (H3K9me3) at DSBs, which stimulates Tip60 acetyltransferase activity and leads to acetylation and activation of ATM. NOTCH1 was shown to prevent FOXO3a and KAT5/Tip60 binding to ATM by competing with FOXO3a. Co-immunoprecipitation, chromodomain-H3K9me3 binding assays, ATM kinase activation assays, reporter assays Cell cycle High 20160506 27524627
2018 Tip60 acetylation of lipin 1 promotes its translocation to the endoplasmic reticulum, where it functions as a phosphatidic acid phosphatase to generate diacylglycerol for triacylglycerol synthesis; Tip60(SA/SA) knock-in mice show reduced body fat and impaired milk TAG production. GSK3-mediated phosphorylation of Tip60 at Ser86 is required for this function; Sirt1 deacetylates lipin 1 to repress this pathway. Knock-in mouse model, in vitro acetyltransferase assay for lipin 1, subcellular fractionation/ER translocation, Sirt1 deacetylation assay, S. cerevisiae genetic validation Nature communications High 29765047
2009 Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX; Sirt1 deacetylates acetylated Tip60 and promotes proteasome-dependent Tip60 degradation, thereby suppressing excessive DNA damage response and Rad51-mediated homologous recombination repair. Co-immunoprecipitation, in vitro deacetylation assay, RNAi knockdown with DNA repair foci analysis Biochemical and biophysical research communications Medium 19895790
2014 HDAC3 interacts with Tip60 and deacetylates its autoacetylation sites (six identified lysine residues); unlike Sirt1, HDAC3 stabilizes rather than degrades Tip60 and co-localizes with it in nucleus and cytoplasm. Both Sirt1 and HDAC3 deacetylation of Tip60 reduces DNA-damage-induced apoptosis. Co-immunoprecipitation, mutagenesis of autoacetylation sites, ubiquitination assays, half-life measurements Journal of Biological Chemistry Medium 25301942
2008 ATF2, in cooperation with Cul3 ubiquitin ligase, promotes proteasomal degradation of TIP60 under non-stressed conditions, attenuating its HAT activity; ionizing radiation decreases ATF2 association with TIP60 on chromatin, stabilizing TIP60 and increasing ATM activation. siRNA knockdown, co-immunoprecipitation, protein half-life measurements, ATM kinase activity assays Journal of Biological Chemistry Medium 18397884
2015 ATF3 directly binds TIP60 adjacent to its catalytic domain, promoting TIP60 acetyltransferase activity and stabilizing TIP60 by promoting USP7-mediated deubiquitination; ATF3 knockdown reduces TIP60 expression and suppresses ATM signaling. Co-immunoprecipitation, in vitro HAT activity assay, deubiquitination assay with USP7, siRNA knockdown with DNA damage readouts Nature communications Medium 25865756
2016 ER stress activates GSK3β which phosphorylates TIP60, triggering TIP60-mediated acetylation of ULK1 to induce autophagy; inhibition of either GSK3β or TIP60 significantly attenuates ER-stress-induced autophagy, and TIP60 overexpression reduces ER-stress-induced CHOP and cell death. Pharmacological inhibition of GSK3β, dominant-negative and phosphorylation-defective TIP60 mutants, autophagy flux assays Cell death & disease Medium 28032867
2019 Tip60 acetylates MARCKS at lysine 165, which is a prerequisite for subsequent MARCKS phosphorylation by PKC; SIRT2 deacetylates MARCKS to counteract this. Phosphorylated MARCKS dissociates from organelles, leading to mitochondrial dysfunction and ER stress causing neural tube defects under diabetic conditions. In vitro acetyltransferase assay, phosphorylation-dead MARCKS knock-in, SIRT2 overexpression in developing neuroepithelium, organelle stress measurements Nature communications High 30655546
2015 KAT5 (Tip60) acetyltransferase is responsible for acetylation and activation of ATM in response to formaldehyde-induced chromatin damage during S-phase; this KAT5-ATM axis is specifically important for the intra-S-phase checkpoint and recovery from low-dose formaldehyde-induced DNA-protein crosslinks. siRNA knockdown of KAT5, ATM acetylation assays, intra-S-phase checkpoint readouts, cell recovery assays Nucleic acids research Medium 26420831
2008 Tip60 directly interacts with the Fanconi anemia protein FANCD2 (confirmed by yeast two-hybrid, co-immunoprecipitation, and co-localization); Tip60 depletion reduces cellular survival after DNA interstrand cross-link damage; Tip60 depletion does not reduce FANCD2 monoubiquitination or nuclear focus formation, placing Tip60 downstream or in a parallel branch of the Fanconi anemia repair pathway. Yeast two-hybrid, co-immunoprecipitation, co-localization, siRNA knockdown with mitomycin C sensitivity assay Journal of Biological Chemistry Medium 18263878
2001 PLIP, a splice variant of KAT5/Tip60, physically interacts with the N-terminal region of cPLA2 and co-localizes with cPLA2 in the nucleus; PLIP expression potentiates cPLA2-mediated prostaglandin E2 production and apoptosis in mesangial cells in a cPLA2-dependent manner. Co-immunoprecipitation, co-localization by fluorescence microscopy, adenoviral gene transfer in cPLA2+/+ vs. cPLA2-/- cells Molecular and cellular biology Medium 11416127
2018 KAT5 acts as an adaptor to recruit TRIB3, which then recruits KAT5 to SMAD3 to induce phosphorylation-dependent acetylation of SMAD3 at K333, sustaining SMAD3 transcriptional activity and TRIB3 expression; metformin disrupts this KAT5/SMAD3 interaction to suppress the feedback loop. Co-immunoprecipitation, in vitro acetyltransferase assay, mutagenesis of K333, luciferase reporter for SMAD3 activity, in vivo mouse tumor models Oncogene Medium 29520103
2018 KAT5 promotes HIV-1 latency by acetylating H4 at the proviral LTR; elevated AcH4 recruits Brd4, which suppresses Tat-SEC interaction required for productive HIV transcription. KAT5 antagonism removes AcH4 and Brd4 from the LTR and reverses latency, validated in primary CD4+ T cell latency models. ChIP for AcH4 and Brd4 at HIV LTR, KAT5 KO/OE, primary cell latency model, patient ART-treated cells PLoS pathogens Medium 29684085
2017 TIP60 acetylates Sp1 at K639, inhibiting Sp1 binding to the TERT promoter and repressing TERT transcription; this mechanism underlies TIP60-mediated growth suppression in HPV-infected cervical cancer cells. ChIP, in vitro acetyltransferase assay for Sp1, mass spectrometry identification of K639 acetylation, expression analysis PLoS pathogens Medium 29045464
2021 Tip60 deletion in hematopoietic stem cells (HSCs) impairs self-renewal and maintenance in a manner dependent on its acetyltransferase activity; Tip60 co-localizes with c-Myc and is required for expression of Myc target genes, associated with H2A.Z acetylation at active chromatin loci. Conditional knockout mouse model, genome-wide ChIP-seq for acH2A.Z, RNA-seq, acetyltransferase-dead rescue experiments Blood High 32542325
2017 KAT-independent function of Tip60 is sufficient for ESC self-renewal and maintenance, while KAT-dependent function is required for differentiation into mesoderm and endoderm; KAT-deficient ESCs show minimal transcriptional or chromatin accessibility changes at Tip60-binding sites but exhibit post-implantation developmental defects in vivo. Catalytic-dead Tip60 mutant in ESCs, Tip60 depletion, gene expression profiling, chromatin accessibility assays, mouse embryo analysis Cell reports High 28445719
2022 Tip60 acetyltransferase activity is essential for neuronal fate specification via acetylation of H2A.Z; loss of Tip60 or acetyl-H2A.Z impairs H3K4me3 deposition and activation of bivalent chromatin-marked lineage-restricted genes, demonstrating that acetyl-H2A.Z regulates epigenetic competence for bivalent gene activation during neuronal differentiation. Proteomics to identify Tip60 in neuronal fate induction, Tip60 KO and H2A.Z acetylation-defective mutants, ChIP-seq for H3K4me3 and chromatin accessibility, direct neuronal conversion assays Molecular cell High 36417913
2018 CDK9 phosphorylates TIP60 at Ser90, which is required for TIP60 interaction with chromatin, histone H3, and RNA Pol II; phosphorylation-deficient TIP60(S90A) shows reduced association with the MYC gene, reduced H4 acetylation, and decreased cell proliferation. Separately, GSK3-mediated Ser86 phosphorylation (primed by S90-p) regulates HAT activity specifically. Kinase assays, Co-IP of TIP60 with chromatin components, ChIP at MYC gene, proliferation assays with phospho-deficient mutants EMBO reports Medium 29335245
2016 NOTCH1 prevents FOXO3a and KAT5/Tip60 from binding to ATM by competing with FOXO3a for ATM binding; loss of FOXO3a binding to ATM leads to loss of KAT5/Tip60 association with ATM and impaired ATM activation. Expression of NOTCH1 or depletion of ATM impairs the FOXO3a-KAT5/Tip60 protein complex. Co-immunoprecipitation, competition binding assays, cell-death assays with pharmacological FOXO3a nuclear induction Cell reports Medium 27524627
2006 Tip60 and p400 (both in the Tip60 complex) are required for UV-induced apoptosis; p400 represses p21 expression in unstressed cells by inhibiting Tip60 function, a property abolished following DNA damage; Tip60 favors expression of proapoptotic p53 target genes by stimulating p53 DNA-binding activity. siRNA knockdown of Tip60 and p400, reporter assays for p53 target genes, cell-cycle and apoptosis analysis EMBO journal Medium 16601686
2019 Yeast Esa1 (KAT5 ortholog) and Gcn5 function as bona fide histone crotonyltransferases; the Esa1-Yng2-Epl1 (piccolo NuA4) complex crotonylates H4 lysines in vitro, and crotonylation selectively affects gene transcription in vivo in an Esa1-dependent manner. In vitro crotonyltransferase assay with piccolo NuA4, mass spectrometry identification of crotonylation sites, in vivo transcriptional analysis in esa1 mutants Journal of Biological Chemistry Medium 31699900
2012 Tip60 functions as an androgen receptor (AR) coactivator by acetylating lysine residues within the KLKK motif of the AR hinge region, promoting AR nuclear localization; Tip60 knockdown induces AR translocation to the cytoplasm, and acetylation-mimicking mutations in the AR NLS caused nuclear localization even without androgen. Luciferase reporter assay, Western blotting, fluorescence microscopy, siRNA knockdown, cell proliferation and cell-cycle analysis The Prostate / PLoS one Medium 19938016 23056207
2019 O-GlcNAcylation of KAT5 (promoted by PCK1 depletion) suppresses KAT5 ubiquitination, stabilizing KAT5; stabilized KAT5 epigenetically activates TWIST1 via H4 acetylation and enhances MMP9/MMP14 expression via c-Myc acetylation, promoting EMT and HCC metastasis. Gain/loss-of-function studies, co-immunoprecipitation, in vitro acetyltransferase assay, ubiquitination assays, ChIP, in vivo lung metastasis model Oncogene Medium 34650217
2011 GPR50 physically interacts with TIP60 (identified by yeast two-hybrid, confirmed by Co-IP and co-localization); co-expression with TIP60 increases perinuclear localization of GPR50 and enables nuclear translocation of GPR50 cytoplasmic tail; GPR50 enhances TIP60 co-activation of glucocorticoid receptor signaling, demonstrated in vivo in Gpr50-/- mice. Yeast two-hybrid, Co-IP, co-localization microscopy, glucocorticoid receptor reporter assay, Gpr50 knockout mouse PLoS one Medium 21858214
2007 Rev-erbbeta recruits Tip60 to the apoCIII promoter; Tip60 acetylates Rev-erbbeta, relieving its transcriptional repression of apoCIII. This de-repression depends specifically on acetylation of the RXKK motif of Rev-erbbeta. HDAC1 is also recruited by Rev-erbbeta to antagonize Tip60 activity at this promoter. Co-immunoprecipitation, ChIP, in vitro acetyltransferase assay, reporter assay with acetylation-site mutants Biochimica et biophysica acta Medium 17996965
2013 ZNF668 promotes Tip60-H2AX interaction in response to ionizing radiation, enabling IR-induced H2AX hyperacetylation and chromatin relaxation; ZNF668 knockdown reduces Tip60-H2AX interaction, impairs homologous recombination repair, and decreases cell survival after IR. Co-immunoprecipitation of Tip60 and H2AX in ZNF668-depleted cells, DNA repair foci analysis, HR repair assay Cell cycle Medium 23777805
2021 LINC00839 lncRNA recruits RUVBL1 to the Tip60 complex and increases its acetyltransferase activity; LINC00839 guides the complex to the NRF1 promoter, promoting acetylation of H4K5 and H4K8, thereby upregulating NRF1 expression and mitochondrial metabolism in colorectal cancer. Co-immunoprecipitation, ChIP for H4 acetylation at NRF1 promoter, in vitro and in vivo CRC proliferation/invasion assays EMBO reports Medium 35876654
2020 De novo heterozygous missense variants in KAT5 (at chromodomain p.Arg53His, and acetyl-CoA binding site p.Cys369Ser, p.Ser413Ala) cause a neurodevelopmental syndrome; purified variant KAT5 proteins fail to support NuA4/TIP60 complex acetylation of histone H4 in chromatin, demonstrating that loss of acetyltransferase activity drives the disease phenotype. In vitro histone acetylation assay with purified variant complexes, transcriptomic analysis of patient fibroblasts, PER1 expression analysis American journal of human genetics High 32822602
2008 The Esa1 chromodomain has an unusual knotted tudor domain structure (NMR solution structure); this knotted tudor domain binds poly(U) RNA, and mutations in the RNA-binding region are lethal in yeast, indicating that RNA binding via this domain is essential for Esa1 function in vivo. NMR structure determination, RNA binding assays, systematic alanine-scanning mutagenesis in yeast Journal of molecular biology Medium 18407291
2016 Tip60 knockdown in glioblastoma cells promotes MT1-MMP transcription and invasion via NF-κB activation; Tip60 thus suppresses NF-κB-mediated MT1-MMP expression to inhibit glioblastoma cell adhesion and invasion. siRNA knockdown, qRT-PCR, invasion assays, NF-κB inhibitor rescue Clinical & experimental metastasis Low 26464124
2019 In Piccolo NuA4, a loop within the Esa1 Tudor domain and a short basic region at the N-terminus of Epl1 EPcA domain are necessary for acetylation of nucleosomal histones but not for nucleosome binding; the Tudor loop is near nucleosomal DNA and the Epl1 basic region contacts the H2A tail and globular H4, suggesting they function post-binding to disengage substrate histone tails. Mutagenesis, crosslinking/proximity assays, nucleosome binding vs. acetylation assays with piccolo NuA4 Molecular and cellular biology Medium 23109429
2021 In Drosophila, the Tip60 complex and its interaction partner Myc regulate genes required for neuroblast maintenance; knockdown of Tip60 complex members results in loss of cortical polarity, symmetric neuroblast division, and premature differentiation via nuclear entry of Prospero; aPKC is the key target gene co-regulated by Myc and the Tip60 complex subunit Domino. RNAi knockdown, transcriptome analysis, live-cell imaging of neuroblast divisions, genetic rescue with aPKC overexpression EMBO journal Medium 29997178

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1993 cPLA2 is phosphorylated and activated by MAP kinase. Cell 1728 8381049
2015 PLIP: fully automated protein-ligand interaction profiler. Nucleic acids research 1418 25873628
2006 Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Molecular cell 607 17189186
2002 Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair. Nature 456 12353039
2012 GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science (New York, N.Y.) 285 22539723
2006 Tip60 in DNA damage response and growth control: many tricks in one HAT. Trends in cell biology 266 16904321
2005 Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature 264 15829968
2000 Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase. Molecular cell 239 11163204
2006 Cellular functions of TIP60. The international journal of biochemistry & cell biology 221 16698308
2010 Tip60: connecting chromatin to DNA damage signaling. Cell cycle (Georgetown, Tex.) 187 20160506
2003 Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Genes & development 177 12782659
2019 Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell 168 31813625
2019 PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma. Autophagy 142 31238788
2002 The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate. Nature structural biology 135 12368900
2003 Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for arachidonic acid release. The Journal of biological chemistry 121 12676927
2012 Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PloS one 114 23056207
2016 Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation. Nature chemical biology 95 26829474
2014 Rational design and validation of a Tip60 histone acetyltransferase inhibitor. Scientific reports 90 24947938
2009 NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5. Molecular and cellular biology 90 19822662
2020 KAT5 acetylates cGAS to promote innate immune response to DNA virus. Proceedings of the National Academy of Sciences of the United States of America 88 32817552
2006 p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress. Molecular and cellular biology 86 16705183
2021 Inhibition of PLA2G4E/cPLA2 promotes survival of random skin flaps by alleviating Lysosomal membrane permeabilization-Induced necroptosis. Autophagy 85 34872436
2010 Tip60 promotes prostate cancer cell proliferation by translocation of androgen receptor into the nucleus. The Prostate 82 19938016
2012 Novel fusion of MYST/Esa1-associated factor 6 and PHF1 in endometrial stromal sarcoma. PloS one 81 22761769
2006 Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression. The EMBO journal 79 16601686
2019 Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription. The Journal of biological chemistry 76 31699900
2025 PLIP 2025: introducing protein-protein interactions to the protein-ligand interaction profiler. Nucleic acids research 70 40347107
2021 Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex. Immunity 68 34107298
2016 Regulation of ER stress-induced autophagy by GSK3β-TIP60-ULK1 pathway. Cell death & disease 67 28032867
2022 Resveratrol Attenuate Myocardial Injury by Inhibiting Ferroptosis Via Inducing KAT5/GPX4 in Myocardial Infarction. Frontiers in pharmacology 65 35685642
2021 Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis. Nature chemical biology 61 34608293
2021 Ketamine suppresses proliferation and induces ferroptosis and apoptosis of breast cancer cells by targeting KAT5/GPX4 axis. Biochemical and biophysical research communications 59 34800882
2018 Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nature communications 59 29765047
2015 A bivalent role of TIP60 histone acetyl transferase in human cancer. Epigenomics 59 26638912
2009 Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX. Biochemical and biophysical research communications 59 19895790
2018 Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex. Nature communications 56 29559617
2016 The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair. Cell death and differentiation 56 26915295
1996 Lipocortin 1 and the control of cPLA2 activity in A549 cells. Glucocorticoids block EGF stimulation of cPLA2 phosphorylation. Biochemical pharmacology 55 8694860
2014 Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1. Molecular & cellular proteomics : MCP 54 25381059
2012 Role of Tip60 in human melanoma cell migration, metastasis, and patient survival. The Journal of investigative dermatology 54 22673729
2008 Bisubstrate Inhibitors of the MYST HATs Esa1 and Tip60. Bioorganic & medicinal chemistry 54 19114310
2001 PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production. Molecular and cellular biology 54 11416127
2016 NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex. Cell reports 52 27524627
2018 Metformin suppresses melanoma progression by inhibiting KAT5-mediated SMAD3 acetylation, transcriptional activity and TRIB3 expression. Oncogene 51 29520103
2021 O-GlcNAc modified-TIP60/KAT5 is required for PCK1 deficiency-induced HCC metastasis. Oncogene 49 34650217
2018 The KAT5-Acetyl-Histone4-Brd4 axis silences HIV-1 transcription and promotes viral latency. PLoS pathogens 49 29684085
2008 Regulation of TIP60 by ATF2 modulates ATM activation. The Journal of biological chemistry 49 18397884
2001 Tip60 is a cell-type-specific transcriptional regulator. Journal of biochemistry 47 11275565
2005 X-ray reflectivity studies of cPLA2{alpha}-C2 domains adsorbed onto Langmuir monolayers of SOPC. Biophysical journal 44 15994899
2022 LINC00839 promotes colorectal cancer progression by recruiting RUVBL1/Tip60 complexes to activate NRF1. EMBO reports 43 35876654
2015 The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60. Nature communications 39 25865756
1996 Cytosolic phospholipase A2 (cPLA2) and lipid mediator release in the brain. Journal of lipid mediators and cell signalling 39 8906538
2009 LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. PloS one 37 19718435
2017 KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency. Cell reports 36 28445719
2008 Novel structural and functional mode of a knot essential for RNA binding activity of the Esa1 presumed chromodomain. Journal of molecular biology 35 18407291
2019 Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy. Nature communications 34 30655546
2018 Tip60: updates. Journal of applied genetics 34 29549519
2010 cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis. The Journal of biological chemistry 34 20452986
2023 Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization. Journal of neuroinflammation 33 36609266
2020 Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance. Blood 33 32542325
1995 Recent insights into the structure, function and biology of cPLA2. Agents and actions. Supplements 33 7610992
2016 RhoA/Rho Kinase Mediates Neuronal Death Through Regulating cPLA2 Activation. Molecular neurobiology 32 27771900
2022 Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation. Molecular cell 31 36417913
2020 FosB recruits KAT5 to potentiate the growth and metastasis of papillary thyroid cancer in a DPP4-dependent manner. Life sciences 31 32891613
2018 Myc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity in Drosophila. The EMBO journal 31 29997178
2009 Collaboration between the essential Esa1 acetyltransferase and the Rpd3 deacetylase is mediated by H4K12 histone acetylation in Saccharomyces cerevisiae. Genetics 31 19596907
2008 Catalytic-site mutations in the MYST family histone Acetyltransferase Esa1. Genetics 31 18245364
2018 Elevation of androgen receptor promotes prostate cancer metastasis by induction of epithelial-mesenchymal transition and reduction of KAT5. Cancer science 30 30142696
2024 The ERK-cPLA2-ACSL4 axis mediating M2 macrophages ferroptosis impedes mucosal healing in ulcerative colitis. Free radical biology & medicine 29 38367927
2015 ATM and KAT5 safeguard replicating chromatin against formaldehyde damage. Nucleic acids research 28 26420831
2024 Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Science (New York, N.Y.) 27 39088653
2014 Regulation of histone acetyltransferase TIP60 function by histone deacetylase 3. The Journal of biological chemistry 27 25301942
2013 KAT5 and KAT6B are in positive regulation on cell proliferation of prostate cancer through PI3K-AKT signaling. International journal of clinical and experimental pathology 27 24294372
2019 KAT5 promotes invasion and metastasis through C-MYC stabilization in ATC. Endocrine-related cancer 26 30400007
2017 TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter. PLoS pathogens 26 29045464
2011 GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling. PloS one 26 21858214
2010 Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage. Genes & development 26 20810648
2008 Tip60 is required for DNA interstrand cross-link repair in the Fanconi anemia pathway. The Journal of biological chemistry 26 18263878
2020 De Novo KAT5 Variants Cause a Syndrome with Recognizable Facial Dysmorphisms, Cerebellar Atrophy, Sleep Disturbance, and Epilepsy. American journal of human genetics 25 32822602
2020 TIP60 in aging and neurodegeneration. Ageing research reviews 25 33091598
2016 MDR1 mediated chemoresistance: BMI1 and TIP60 in action. Biochimica et biophysica acta 25 27295567
2012 Piccolo NuA4-catalyzed acetylation of nucleosomal histones: critical roles of an Esa1 Tudor/chromo barrel loop and an Epl1 enhancer of polycomb A (EPcA) basic region. Molecular and cellular biology 25 23109429
2024 Structure of the human TIP60 complex. Nature communications 24 39154037
2024 Structure of the human TIP60-C histone exchange and acetyltransferase complex. Nature 24 39260417
2021 Role of histone acetyltransferases MOF and Tip60 in genome stability. DNA repair 24 34399315
2021 JAZF1, A Novel p400/TIP60/NuA4 Complex Member, Regulates H2A.Z Acetylation at Regulatory Regions. International journal of molecular sciences 23 33445503
2014 Urocortin affects migration of hepatic cancer cell lines via differential regulation of cPLA2 and iPLA2. Cellular signalling 23 24518041
2011 PLU1 histone demethylase decreases the expression of KAT5 and enhances the invasive activity of the cells. The Biochemical journal 23 21574959
2021 ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4. Nucleic acids research 22 34417612
2020 Metabolic Roles of Androgen Receptor and Tip60 in Androgen-Dependent Prostate Cancer. International journal of molecular sciences 22 32927797
2018 Tip60 Suppresses Cholangiocarcinoma Proliferation and Metastasis via PI3k-AKT. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 22 30308494
2022 HDAC5 Loss Enhances Phospholipid-Derived Arachidonic Acid Generation and Confers Sensitivity to cPLA2 Inhibition in Pancreatic Cancer. Cancer research 21 36102738
2019 Quantifying Tip60 (Kat5) stratifies breast cancer. Scientific reports 21 30846725
2018 Modulation of Nuclear Receptor Function by Chromatin Modifying Factor TIP60. Endocrinology 21 29420715
2016 Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-κB pathway. Clinical & experimental metastasis 21 26464124
2013 Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage. Cell cycle (Georgetown, Tex.) 21 23777805
2018 Tip60 complex promotes expression of a differentiation factor to regulate germline differentiation in female Drosophila. Molecular biology of the cell 20 30230973
2007 The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter. Biochimica et biophysica acta 20 17996965
2018 CDK9-mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery. EMBO reports 19 29335245
2017 Chromatin Regulation by the NuA4 Acetyltransferase Complex Is Mediated by Essential Interactions Between Enhancer of Polycomb (Epl1) and Esa1. Genetics 19 28108589