Affinage

JAZF1

Juxtaposed with another zinc finger protein 1 · UniProt Q86VZ6

Length
243 aa
Mass
27.1 kDa
Annotated
2026-06-10
91 papers in source corpus 23 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

JAZF1 is a zinc-finger transcriptional co-repressor that couples nuclear-receptor regulation to chromatin modification, governing metabolic, developmental, and proliferative programs (PMID:15302918, PMID:33445503). It directly binds the ligand-binding domain of the orphan nuclear receptor TR4/TAK1 through a defined interaction domain, and crystallography shows it engages a non-canonical surface of the TR4 LBD—stabilizing a previously unobserved α13 helix that reinforces an autorepressed TR4 conformation and excludes coactivators such as SRC-1 and CREBBP, thereby blunting TR4-driven transcription (PMID:15302918, PMID:36651297). Independently, JAZF1 is a subunit of a p400/TIP60/NuA4 sub-complex (containing MBTD1, excluding ANP32E) that promotes H2A.Z acetylation at over a thousand regulatory sites and sustains expression of ribosome-biogenesis genes (PMID:33445503). Through these activities it acts as a master metabolic regulator: it drives ribosomal protein and rRNA synthesis required for insulin translation and β-cell survival (PMID:32640216, PMID:33555104), represses hepatic lipogenesis and cholesterol synthesis via SREBP-1c/LXRE, HMGCR/CREB, and AMPK axes (PMID:30154417, PMID:25499349), suppresses gluconeogenesis through PI3K/Akt signaling both hepatically and via central hypothalamic circuits (PMID:25614086, PMID:32275331), and sits upstream of the GH–IGF-1–HNF4α growth axis (PMID:36442127). In other lineages JAZF1 represses γ-globin (HBG) in adult erythroid cells (PMID:35322124) and safeguards endometrial stromal cell survival and decidualization by interacting with Purβ to repress G0S2 (PMID:37244968). The recurrent t(7;17) JAZF1-SUZ12 fusion in endometrial stromal sarcoma destabilizes EZH2 and EED, reduces PRC2 histone-methyltransferase activity and H3K27 trimethylation, and enhances proliferation (PMID:11371647, PMID:27845897).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2001 High

    Established JAZF1 as a recurrent fusion partner in endometrial stromal tumors, defining its first disease link before any functional role was known.

    Evidence Cytogenetics and RT-PCR of tumor RNA identifying the t(7;17) JAZF1-SUZ12 fusion transcript

    PMID:11371647

    Open questions at the time
    • Did not define the normal function of JAZF1
    • Did not explain how the fusion drives tumorigenesis
  2. 2004 High

    Identified the first molecular activity of JAZF1—repression of the nuclear receptor TR4/TAK1—answering what the protein does biochemically.

    Evidence Yeast/mammalian two-hybrid, GST pull-down, mutagenesis of the TID, and reporter assays in mammalian cells

    PMID:15302918

    Open questions at the time
    • Structural basis of the interaction unresolved
    • Did not identify target genes downstream of TR4 repression
  3. 2013 Medium

    Connected a JAZF1 diabetes-risk variant to allele-specific enhancer activity and PDX1 binding, linking genetic association to β-cell regulatory function.

    Evidence Open chromatin mapping, luciferase enhancer assays in insulinoma cells, and DNA affinity capture-mass spectrometry

    PMID:23328127

    Open questions at the time
    • Effect of the variant on endogenous JAZF1 expression in human islets not shown
    • Mechanism of PDX1 repressor complex assembly unresolved
  4. 2014 Medium

    Demonstrated JAZF1 controls lipid metabolism through both direct (HMGCR/CREB) and indirect (PPAR-mediated) transcriptional mechanisms.

    Evidence Adenoviral overexpression in ApoE-KO and 3T3-L1 systems, dual-luciferase reporters, ChIP, and pharmacological/siRNA dissection of PPARα/βδ

    PMID:24930994 PMID:25499349

    Open questions at the time
    • Whether JAZF1 acts directly or via cofactors at the HMGCR promoter not fully resolved
    • ChIP showed no direct JAZF1 binding at the visfatin PPRE
  5. 2015 Medium

    Showed JAZF1 improves systemic glucose handling by suppressing hepatic glucose production through PI3K/Akt and gluconeogenic enzyme repression.

    Evidence Transgenic and adenoviral overexpression in db/db mice, hyperinsulinemic-euglycemic clamps, and LY294002 inhibition

    PMID:25614086

    Open questions at the time
    • Direct transcriptional targets at PEPCK/G6Pase promoters not mapped
    • Relationship to TR4 repression in this context unclear
  6. 2018 Medium

    Extended JAZF1's hepatic role to lipogenesis suppression via SREBP-1c/LXRE and AMPK, positioning it as a protector against steatosis.

    Evidence Transgenic HFD mice, LXRE luciferase reporters, AMPK phospho-blots, and Compound C rescue

    PMID:30154417

    Open questions at the time
    • Direct vs. indirect action at the LXRE not definitively separated
    • Upstream activator of AMPK by JAZF1 unidentified
  7. 2020 High

    Defined a unifying nuclear function—JAZF1 drives ribosome biogenesis—linking its metabolic phenotypes to a defect in the protein-synthesis machinery, and added a hypothalamic axis for glucose control.

    Evidence Jazf1-KO mice with ribosome-biogenesis and ER-stress assays, human islet validation, and MBH viral overexpression with clamps and vagotomy

    PMID:32275331 PMID:32640216

    Open questions at the time
    • Direct genomic targets among ribosomal/rRNA processing genes not enumerated
    • How metabolic stress excludes JAZF1 from the nucleus is unknown
  8. 2021 High

    Placed JAZF1 within the p400/TIP60/NuA4 complex as an H2A.Z acetylation regulator, providing the chromatin-level mechanism underlying its ribosome-biogenesis transcriptional control.

    Evidence Mass spectrometry of H2A.Z chaperone complexes, genome-wide H2A.Z-acetyl ChIP-seq, and RNA-seq after JAZF1 depletion

    PMID:33445503

    Open questions at the time
    • How JAZF1 targets the complex to specific enhancers is unresolved
    • Relationship between this complex and TR4 corepression not addressed
  9. 2021 Medium

    Tied JAZF1 to β-cell specification and proliferation through cyclin A2, integrating its diabetes-associated role into cell differentiation.

    Evidence Jazf1-KO iPSC β-cell differentiation, MIN6 gain/loss-of-function, and Jazf1+/- mouse glucose-homeostasis studies

    PMID:33555104

    Open questions at the time
    • Direct transcriptional targets governing β-cell maturation not mapped
    • Mechanism of cyclin A2 modulation unresolved
  10. 2022 Medium

    Identified JAZF1 as an upstream regulator of the GH–IGF-1–HNF4α growth axis, broadening its role from glucose/lipid metabolism to organismal growth.

    Evidence Jazf1-KO mice with body composition, clamps, plasma IGF-1, liver transcriptome GSEA, and GH-stimulated human hepatocyte knockdown

    PMID:36442127

    Open questions at the time
    • Whether JAZF1 directly regulates HNF4α transcription not established
    • Mechanistic step linking JAZF1 to GH-induced IGF-1 unknown
  11. 2022 Medium

    Mechanistically dissected the oncogenic fusion: JAZF1-SUZ12 disrupts PRC2 integrity and H3K27me3, and the fusion itself can be RNA-induced, illuminating both its activity and origin.

    Evidence Reconstituted PRC2 HMT assays on nucleosome arrays, patient-tissue immunostaining, Suz12-/- rescue, plus chimeric-RNA induction with hormone inhibition

    PMID:27845897 PMID:34928964

    Open questions at the time
    • Genome-wide target genes derepressed by the fusion not catalogued
    • In vivo relevance of RNA-driven fusion formation unconfirmed
  12. 2023 High

    Resolved the structural basis of JAZF1-mediated repression, showing it stabilizes a novel α13 helix to lock TR4 in an autorepressed, coactivator-excluding state.

    Evidence X-ray crystallography of TR4LBD-JAZF1 complex with cancer-mutation mutagenesis and transcription assays

    PMID:36651297

    Open questions at the time
    • Structure of full-length JAZF1 and its zinc fingers not determined
    • How this mode relates to JAZF1's chromatin-complex activity unknown
  13. 2023 Medium

    Showed JAZF1 protects endometrial stromal cells via Purβ-dependent G0S2 repression, defining a survival/decidualization function with disease relevance to recurrent abortion.

    Evidence siRNA knockdown in hESCs, decidualization and apoptosis assays, JAZF1-Purβ Co-IP, G0S2 promoter ChIP/reporter, and patient tissue

    PMID:37244968

    Open questions at the time
    • Whether JAZF1 binds the G0S2 promoter directly or only via Purβ not resolved
    • Reciprocal interaction validation beyond single Co-IP not shown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How JAZF1's two characterized activities—TR4 LBD corepression and p400/TIP60-mediated H2A.Z acetylation—are coordinated at specific loci to produce its tissue-specific metabolic, developmental, and oncogenic outputs remains unresolved.
  • No unified model integrating nuclear-receptor corepression with chromatin-modifying complex membership
  • Direct genome-wide JAZF1 binding map across tissues not established
  • Determinants of context-specific activation versus repression unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 9 GO:0003677 DNA binding 2 GO:0098772 molecular function regulator activity 2 GO:0042393 histone binding 1
Localization
GO:0005634 nucleus 2 GO:0000228 nuclear chromosome 1
Pathway
R-HSA-1430728 Metabolism 5 R-HSA-74160 Gene expression (Transcription) 5 R-HSA-1643685 Disease 2 R-HSA-4839726 Chromatin organization 2 R-HSA-8953854 Metabolism of RNA 1
Partners
MBTD1PDX1PURΒSUZ12TIP60TR4/TAK1
Complex memberships
PRC2 (via JAZF1-SUZ12 fusion)p400/TIP60/NuA4 complex

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 JAZF1 (TIP27) physically interacts with the ligand-binding domain (LBD) of nuclear orphan receptor TAK1/TR4 through a defined TAK1-interaction domain (TID, residues Asp39–Lys79) on JAZF1, and the TAK1-LBD from helix 3 to the C-terminus is required for optimal interaction. This interaction represses DR1-dependent transcriptional activation by TAK1, without inhibiting TAK1 homodimerization or DNA binding, likely by affecting co-activator recruitment. JAZF1 and TAK1 co-localize in the nucleus. Yeast two-hybrid, mammalian two-hybrid, GST pull-down assay, confocal microscopy co-localization, transcriptional reporter assays Nucleic acids research High 15302918
2001 A chromosomal translocation t(7;17)(p15;q21) fuses JAZF1 (chromosome 7p15) with JJAZ1/SUZ12 (chromosome 17q21) in endometrial stromal tumors, producing a JAZF1-JJAZ1 (JAZF1-SUZ12) fusion transcript detected by RT-PCR in tumor RNA. Cytogenetic analysis, RT-PCR of tumor RNA, breakpoint cloning Proceedings of the National Academy of Sciences of the United States of America High 11371647
2017 The JAZF1-SUZ12 fusion protein disrupts the PRC2 complex: it destabilizes EZH2 and EED components, reduces histone methyltransferase (HMT) activity of reconstituted PRC2 on nucleosome array substrates, decreases H3K27 trimethylation in ESS tissue harboring t(7;17) (but not H3K9 methylation), decreases PRC2 binding affinity to target chromatin loci, and fails to rescue neuronal differentiation in Suz12-/- ES cells while enhancing cell proliferation. Co-transfection assays, in vitro reconstituted PRC2 HMT assay with nucleosome arrays, chromatin binding assays, H3K27me3/H3K9me3 immunostaining in patient tissue, rescue experiments in Suz12-/- ES cells Oncotarget High 27845897
2023 Crystal structures of the TR4LBD–JAZF1 complex reveal that JAZF1 binds to an unidentified surface of the TR4 LBD (distinct from the classical AF-2 coactivator surface) and stabilizes an α13 helix not previously reported in the nuclear receptor family. This binding reinforces an autorepressed conformation of TR4 and suppresses coactivator (SRC-1, CREBBP) binding, thereby inhibiting TR4 transcriptional activation. Cancer-associated mutations at this interface impair these interactions and reduce TR4 transcriptional repression in vitro and in vivo. X-ray crystallography (high-resolution crystal structures of TR4DBD, TR4DBD-DNA, and TR4LBD-JAZF1 complexes), in vitro transcriptional activation assays, mutagenesis of cancer-associated residues Nucleic acids research High 36651297
2021 JAZF1 is a member of the p400/TIP60/NuA4 chromatin-modifying complex, specifically associating with a p400 sub-complex containing MBTD1 but excluding ANP32E. JAZF1 depletion reduces H2A.Z acetylation levels at >1000 regulatory sites genome-wide (ChIP-seq) without affecting H2A.Z nucleosome positioning, and causes transcriptome changes including downregulation of ribosome biogenesis genes. JAZF1 associates with the histone acetyltransferase TIP60, whose depletion causes correlated H2A.Z deacetylation at JAZF1-targeted enhancer regions. Mass spectrometry identification of H2A.Z chaperone complexes, ChIP-seq (H2A.Z acetylation genome-wide), RNA-seq (transcriptome after JAZF1 depletion), Co-IP/complex association assays International journal of molecular sciences High 33445503
2020 JAZF1 is a transcriptional regulator of ribosome biogenesis. Genetic deletion of Jazf1 in mice causes global impairment of protein and insulin synthesis mediated by defects in ribosomal protein synthesis, ribosomal RNA processing, and aminoacyl-tRNA synthetase expression, leading to ER stress and increased β-cell susceptibility to apoptosis. JAZF1 is excluded from the nucleus under metabolic stress and its expression is reduced in diabetic islets. Jazf1 knockout mice, islet isolation, ribosome biogenesis assays, protein synthesis measurements, ER stress markers, subcellular fractionation/localization, gene expression profiling in murine T2D and human islets under metabolic stress Cell reports High 32640216
2018 JAZF1 suppresses hepatic SREBP-1c expression through inhibition of transcriptional activity at liver X receptor response elements (LXREs) in the SREBP-1c promoter, and increases AMPK phosphorylation in hepatocytes. Overexpression of JAZF1 in transgenic mice reduces lipogenesis gene expression and protects against HFD-induced hepatic steatosis; these effects are partially blocked by the AMPK inhibitor Compound C. JAZF1 transgenic mice (HFD model), hepatocyte overexpression/knockdown, LXRE luciferase reporter assay, AMPK phosphorylation western blot, gene expression analysis Cell death & disease Medium 30154417
2015 JAZF1 (TIP27) overexpression in transgenic mice and db/db mice reduces hepatic glucose production and improves insulin sensitivity through a PI3-kinase/Akt-dependent mechanism: overexpression increases phosphorylation of insulin receptor, IRS-1, AMPK, and Akt in liver, decreases expression of gluconeogenic enzymes PEPCK and G6Pase, and these effects are abolished by the PI3-kinase inhibitor LY294002. TIP27-Tg mice and adenovirus-mediated overexpression in db/db mice, hyperinsulinemic-euglycemic clamp, western blot for insulin signaling molecules, RT-qPCR, pharmacological inhibition with LY294002 International journal of obesity Medium 25614086
2014 JAZF1 overexpression inhibits hepatic cholesterol de novo synthesis by repressing HMGCR transcriptional activity through a CREB-dependent mechanism (inhibiting CRE activity in the HMGCR promoter), demonstrated by dual-luciferase reporter assay. In ApoE KO mice, JAZF1 overexpression decreases serum cholesterol and reduces atherosclerotic plaque area. Adenovirus-mediated JAZF1 overexpression in ApoE KO mice, dual-luciferase reporter assay for HMGCR promoter CREB activity, [14C]-acetate cholesterol synthesis measurement, hyperinsulinemic-euglycemic clamp, histological plaque quantification International journal of cardiology Medium 25499349
2020 Central (mediobasal hypothalamus) JAZF1 activation in HFD-fed rats reduces hepatic glucose production (HGP) by increasing hypothalamic insulin receptor (InsR)-PI3K-Akt signaling and decreasing AMPK phosphorylation. This effect requires intact KATP channels and the hepatic branch of the vagus nerve (disrupted by vagotomy), and is blocked by central AMPK activation (AICAR). JAZF1 also elevates InsR and Akt phosphorylation in SH-SY5Y neuronal cells upon insulin stimulation. MBH adenovirus-mediated JAZF1 overexpression in rats, pancreatic-euglycemic clamp to measure HGP, KATP channel inhibition, hepatic vagotomy, central AICAR infusion, western blot for signaling molecules, cell line experiments FASEB journal Medium 32275331
2022 Deletion of Jazf1 in mice results in reduced plasma IGF-1, early growth retardation (shorter stature in young KO mice), and late-onset muscle insulin resistance exacerbated by HFD. Gene set enrichment analysis in KO liver identified decreased hepatocyte nuclear factor 4α (HNF4α), and JAZF1 knockdown in human hepatocytes inhibited GH-induced IGF-1 expression, placing JAZF1 upstream of the GH–IGF-1 axis and HNF4α in growth and metabolic regulation. Jazf1 knockout mice, 1H-NMR body composition, hyperinsulinemic-euglycemic clamp, IGF-1/GH plasma measurements, gene set enrichment analysis of liver transcriptome, JAZF1 knockdown in human hepatocytes with GH stimulation Proceedings of the National Academy of Sciences of the United States of America Medium 36442127
2023 JAZF1 safeguards human endometrial stromal cell (hESC) survival and decidualization by transcriptionally repressing G0S2. JAZF1 interacts with G0S2 transcriptional activator Purβ to restrict G0S2 expression; JAZF1 depletion in hESCs increases G0S2, causing apoptosis and defective decidualization. This mechanism was validated in decidual tissue from recurrent spontaneous abortion patients showing low JAZF1, high G0S2, and excess apoptosis. JAZF1 siRNA knockdown in hESCs, decidualization assays, apoptosis assays, Co-IP to demonstrate JAZF1–Purβ interaction, ChIP/reporter assays for G0S2 promoter, patient tissue validation (RSA vs. controls) Communications biology Medium 37244968
2022 JAZF1 (ZNF802) functions as a transcriptional repressor of the γ-globin (HBG) gene in adult erythroid cells. shRNA-mediated knockdown of ZNF802/JAZF1 in β0-thalassemia/HbE erythroblasts increased HBG transcription and translation, raising HbF levels to 35%, without affecting erythroblast proliferation or differentiation. Lentiviral shRNA knockdown of ZNF802/JAZF1 in β0-thalassemia/HbE erythroblasts, RT-qPCR for HBG mRNA, HPLC/western blot for HbF protein, flow cytometry for erythroblast differentiation Scientific reports Medium 35322124
2018 Jazf1 promotes multiciliated cell (MCC) differentiation in mouse airway epithelium. Overexpression of Jazf1 in mouse embryonic tracheal explants promoted MCC differentiation, including cooperative effects with the canonical MCC transcription factor Foxj1. Knockdown of Jazf1 in adult mouse airway epithelial cultures impaired ciliated cell differentiation. Jazf1 likely functions downstream of IL-6 signaling and upstream of Foxj1 in the MCC differentiation pathway. Overexpression in mouse embryonic tracheal explants, siRNA knockdown in adult mouse airway epithelial cultures, Foxj1 co-expression epistasis experiments, IL-6 pathway genetic placement Biology open Medium 29661797
2017 Jazf1 promotes prostate cancer cell proliferation, colony formation, migration, and invasion via activation of the JNK/c-Jun phosphorylation pathway leading to upregulation of Slug and epithelial-mesenchymal transition (EMT; increased vimentin, decreased E-cadherin). In xenograft models, Jazf1-overexpressing tumors were larger and Jazf1-knockdown tumors were smaller. Jazf1 overexpression and knockdown in DU145 and LNCaP prostate cancer cell lines, transwell migration/invasion assays, microarray for Slug identification, western blot for JNK/c-Jun phosphorylation and EMT markers, xenograft mouse model Oncotarget Medium 29416651
2014 JAZF1 promotes visfatin expression in adipocytes indirectly through upregulation of PPARα and PPARβ/δ, which then activate the visfatin promoter via PPRE elements. Luciferase reporter assays confirmed JAZF1 activates visfatin transcription; ChIP assays showed JAZF1 does not directly bind the visfatin PPRE. The visfatin induction was abolished by PPARα antagonist GW6471 and PPARβ/δ antagonist GSK3787, and confirmed with siRNA knockdown of PPARα and PPARβ/δ. JAZF1 simultaneously inhibits TAK1 and PPARγ expression. JAZF1 overexpression vector and siRNA in 3T3-L1 adipocytes, luciferase reporter assay for visfatin promoter, ChIP assay for JAZF1–visfatin PPRE binding, pharmacological antagonists and siRNA for PPARα/PPARβ/δ, western blot and RT-qPCR Metabolism: clinical and experimental Medium 24930994
2013 rs1635852 in JAZF1 intron 1 displays allele-specific enhancer activity in pancreatic insulinoma cells: the T (risk) allele shows lower transcriptional activity than the C allele, and the T allele preferentially binds PDX1 (pancreatic master regulator) as part of a repressor complex identified by DNA affinity capture and mass spectrometry. Open chromatin mapping to prioritize variants, luciferase enhancer assays in 832/13 and MIN6 cells, DNA affinity capture with mass spectrometry to identify PDX1 as the T-allele-preferential binding factor Diabetes Medium 23328127
2021 JAZF1 regulates β-cell differentiation and glucose homeostasis: Jazf1-KO iPSC-derived β-cells show reduced expression of β-cell specification/maturation genes and lower insulin/C-peptide secretion. Jazf1 heterozygous KO mice have lower serum insulin, reduced pancreatic insulin expression, smaller β-cell size, and impaired glucose homeostasis. JAZF1 modulates cyclin A2 levels in this context. Jazf1-KO iPSC differentiation to β-cells, MIN6 gain/loss-of-function, Jazf1+/- mice glucose tolerance and insulin measurements, teratoma assays for proliferation markers The FEBS journal Medium 33555104
2019 JAZF1 directly regulates vimentin and E-cadherin expression (EMT markers) in gastric cancer cells: JAZF1 was validated as a direct target of miR-1275 by luciferase assay, and overexpression of JAZF1 upregulated vimentin and downregulated E-cadherin, promoting migration and invasion in vitro and in vivo. ChIP analysis confirmed JAZF1 directly regulates vimentin transcription. Luciferase reporter assay (miR-1275 targeting of JAZF1), western blot, RT-qPCR, transwell migration/invasion, xenograft, ChIP assay for JAZF1 at vimentin promoter BMC cancer Medium 31357957
2019 JAZF1 overexpression suppresses cell proliferation, induces G0/G1 arrest, and promotes apoptosis in papillary thyroid carcinoma BCPAP cells by suppressing the TAK1/NF-κB signaling pathway: JAZF1 overexpression decreased TAK1 and NF-κB p-p65 protein levels and decreased Bcl-2 while increasing Bax, without affecting NF-κB p65 mRNA/protein expression levels. Adenovirus-mediated JAZF1 overexpression in BCPAP cells, cell proliferation/colony assays, cell cycle analysis, apoptosis flow cytometry, western blot for TAK1, NF-κB p65, p-p65, Bcl-2, Bax OncoTargets and therapy Low 31819531
2018 miRNA-31-5p targets JAZF1 directly (validated by dual-luciferase assay) in human spermatogonial stem cells (SSCs); JAZF1 silencing reduces SSC proliferation, DNA synthesis, and increases apoptosis, and decreases cyclin A2 but not cyclin D1 or cyclin E1 levels, placing JAZF1 in a PAK1–JAZF1–cyclin A2 pathway controlling SSC fate. Dual-luciferase reporter assay for miR-31-5p targeting of JAZF1, CCK-8/EDU proliferation assays, Annexin V/PI apoptosis, JAZF1 siRNA knockdown, western blot for cyclins Molecular therapy. Nucleic acids Low 30583099
2015 JAZF1 overexpression in C2C12 myoblasts promotes cell proliferation and transcriptionally represses MEF2C and MRF4 (and their downstream genes including AMPD1), thereby retarding myogenic differentiation. JAZF1-mediated repression of Ampd1 acts through MEF2-binding sites and E-box elements in the Ampd1 proximal regulatory region rather than through TR4/JAZF1 complex binding sites. JAZF1 overexpression and AMPD1 overexpression or JAZF1 downregulation both impaired AMPK phosphorylation. JAZF1 overexpression in C2C12 cells, gene array analysis, promoter activity assays with MEF2-site and E-box mutations, RT-qPCR, western blot for AMPK phosphorylation Experimental cell research Low 26101156
2021 RNA-driven formation of the JAZF1-SUZ12 fusion gene can be induced in human endometrial stromal cells by expressing designed antisense (but not sense) chimeric RNAs in a sequence-dependent manner; this process is inhibited by estrogen or progesterone. The induced fusion gene was validated at both RNA and genomic DNA levels. Transfection of designed chimeric RNAs in human endometrial stromal cells, RT-PCR and genomic PCR validation of JAZF1-SUZ12 fusion, sense vs. antisense chimeric RNA comparison, hormone inhibition experiments PLoS genetics Medium 34928964

Source papers

Stage 0 corpus · 91 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proceedings of the National Academy of Sciences of the United States of America 288 11371647
2006 Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma. Cancer research 183 16397222
2008 Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes. Diabetes 121 18567820
2004 Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity. The American journal of surgical pathology 87 15043312
2004 TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4. Nucleic acids research 85 15302918
2008 Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis. Human molecular genetics 83 18952825
2007 Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. The American journal of surgical pathology 82 17197920
2009 Uterine tumors resembling ovarian sex cord tumors (UTROSCT) lack the JAZF1-JJAZ1 translocation frequently seen in endometrial stromal tumors. The American journal of surgical pathology 69 19542872
2005 JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue. The Journal of molecular diagnostics : JMD 67 16049311
2003 Cytogenetic and molecular genetic analyses of endometrial stromal sarcoma: nonrandom involvement of chromosome arms 6p and 7p and confirmation of JAZF1/JJAZ1 gene fusion in t(7;17). Cancer genetics and cytogenetics 67 12850374
2007 High frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal tumors with smooth muscle differentiation by interphase FISH detection. The American journal of surgical pathology 64 17667554
2017 The JAZF1-SUZ12 fusion protein disrupts PRC2 complexes and impairs chromatin repression during human endometrial stromal tumorogenesis. Oncotarget 54 27845897
2010 The role of JAZF1 on lipid metabolism and related genes in vitro. Metabolism: clinical and experimental 54 20580384
2018 JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism. Cell death & disease 47 30154417
2021 Nobiletin promotes the pyroptosis of breast cancer via regulation of miR-200b/JAZF1 axis. The Kaohsiung journal of medical sciences 43 33728753
2020 The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress. Cell reports 43 32640216
2017 Identification of PTPN22, ST6GAL1 and JAZF1 as psoriasis risk genes demonstrates shared pathogenesis between psoriasis and diabetes. Experimental dermatology 42 28603863
2016 JAZF1/SUZ12 gene fusion in endometrial stromal sarcomas. Orphanet journal of rare diseases 42 26879382
2018 miRNA-31-5p Mediates the Proliferation and Apoptosis of Human Spermatogonial Stem Cells via Targeting JAZF1 and Cyclin A2. Molecular therapy. Nucleic acids 41 30583099
2010 HNF1B and JAZF1 genes, diabetes, and prostate cancer risk. The Prostate 41 19998368
2013 Allele-specific transcriptional activity at type 2 diabetes-associated single nucleotide polymorphisms in regions of pancreatic islet open chromatin at the JAZF1 locus. Diabetes 40 23328127
2013 Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet. Biochemical and biophysical research communications 38 24380856
2008 An endometrial stromal sarcoma cell line with the JAZF1/PHF1 chimera. Cancer genetics and cytogenetics 35 18722875
2017 A recurrent endometrial stromal sarcoma harbors the novel fusion JAZF1-BCORL1. Gynecologic oncology reports 34 28331900
2012 Endometrial sarcomas: an immunohistochemical and JAZF1 re-arrangement study in low-grade and undifferentiated tumors. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 33 22918161
2014 JAZF1 can regulate the expression of lipid metabolic genes and inhibit lipid accumulation in adipocytes. Biochemical and biophysical research communications 32 24583129
2019 JAZF1, a relevant metabolic regulator in type 2 diabetes. Diabetes/metabolism research and reviews 31 30838734
2015 Transcription factor TIP27 regulates glucose homeostasis and insulin sensitivity in a PI3-kinase/Akt-dependent manner in mice. International journal of obesity (2005) 31 25614086
2021 TSC2-mutant uterine sarcomas with JAZF1-SUZ12 fusions demonstrate hybrid features of endometrial stromal sarcoma and PEComa and are responsive to mTOR inhibition. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 30 34561551
2019 MicroRNA-1275 inhibits cell migration and invasion in gastric cancer by regulating vimentin and E-cadherin via JAZF1. BMC cancer 28 31357957
2018 JAZF1 Inhibits Adipose Tissue Macrophages and Adipose Tissue Inflammation in Diet-Induced Diabetic Mice. BioMed research international 28 29765984
2013 JAZF1 rearrangement in a mesenchymal tumor of nonendometrial stromal origin: report of an unusual ossifying sarcoma of the heart demonstrating JAZF1/PHF1 fusion. The American journal of surgical pathology 28 23629446
2021 microRNA-19b-3p-containing extracellular vesicles derived from macrophages promote the development of atherosclerosis by targeting JAZF1. Journal of cellular and molecular medicine 27 34910364
2011 JAZF1 and JJAZ1 gene fusion in primary extrauterine endometrial stromal sarcoma. Human pathology 27 21316079
2014 Overexpression of JAZF1 protected ApoE-deficient mice from atherosclerosis by inhibiting hepatic cholesterol synthesis via CREB-dependent mechanisms. International journal of cardiology 26 25499349
2011 Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study. Journal of human genetics 25 22113416
2024 Exosomes Derived from Adipose Stem Cells Enhance Angiogenesis in Diabetic Wound Via miR-146a-5p/JAZF1 Axis. Stem cell reviews and reports 24 38393667
2021 JAZF1, A Novel p400/TIP60/NuA4 Complex Member, Regulates H2A.Z Acetylation at Regulatory Regions. International journal of molecular sciences 24 33445503
2010 Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 24 20406958
2016 Molecular Cytogenetic Analysis of JAZF1, PHF1, and YWHAE in Endometrial Stromal Tumors: Discovery of Genetic Complexity by Fluorescence in Situ Hybridization. The Journal of molecular diagnostics : JMD 23 27154512
2020 Effect of central JAZF1 on glucose production is regulated by the PI3K-Akt-AMPK pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22 32275331
2017 Expression of JAZF1, ABCC8, KCNJ11and Notch2 genes and vitamin D receptor polymorphisms in type 2 diabetes, and their association with microvascular complications. Therapeutic advances in endocrinology and metabolism 22 28794851
2017 Jazf1 promotes prostate cancer progression by activating JNK/Slug. Oncotarget 22 29416651
2014 JAZF1 regulates visfatin expression in adipocytes via PPARα and PPARβ/δ signaling. Metabolism: clinical and experimental 22 24930994
2007 Extrauterine endometrial stromal sarcoma with JAZF1/JJAZ1 fusion confirmed by RT-PCR and interphase FISH presenting as an inguinal tumor. Virchows Archiv : an international journal of pathology 22 17235569
2019 Over-expression of JAZF1 promotes cardiac microvascular endothelial cell proliferation and angiogenesis via activation of the Akt signaling pathway in rats with myocardial ischemia-reperfusion. Cell cycle (Georgetown, Tex.) 20 31177938
2015 Association of JAZF1 and TSPAN8/LGR5 variants in relation to type 2 diabetes mellitus in a Saudi population. Diabetology & metabolic syndrome 20 26500707
2019 JAZF1 Suppresses Papillary Thyroid Carcinoma Cell Proliferation and Facilitates Apoptosis via Regulating TAK1/NF-κB Pathways. OncoTargets and therapy 17 31819531
2018 Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium. Biology open 16 29661797
2011 Overexpression of Jazf1 induces cardiac malformation through the upregulation of pro-apoptotic genes in mice. Transgenic research 15 21221781
2018 Low-grade Endometrioid Stromal Sarcoma of the Paratestis: A Novel Report With Molecular Confirmation of JAZF1/SUZ12 Translocation. The American journal of surgical pathology 13 29394168
2015 JAZF1 promotes proliferation of C2C12 cells, but retards their myogenic differentiation through transcriptional repression of MEF2C and MRF4-Implications for the role of Jazf1 variants in oncogenesis and type 2 diabetes. Experimental cell research 13 26101156
2021 Jazf1 acts as a regulator of insulin-producing β-cell differentiation in induced pluripotent stem cells and glucose homeostasis in mice. The FEBS journal 11 33555104
2021 ADCY5, CAPN10 and JAZF1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes. Life (Basel, Switzerland) 11 34440550
2019 Di(2-ethylhexyl)phthalate induces reproductive toxicity via JAZF1/TR4 pathway and oxidative stress in pubertal male rats. Toxicology and industrial health 11 30755103
2009 Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study. BMC proceedings 11 20018066
2023 JAZF1 safeguards human endometrial stromal cells survival and decidualization by repressing the transcription of G0S2. Communications biology 10 37244968
2020 Effects of Adenovirus-Mediated Overexpression of JAZF1 on Chronic Inflammation: An In Vitro and In Vivo Study. Medical science monitor basic research 10 32655126
2014 Gene-environment interactions between JAZF1 and occupational and household lead exposure in prostate cancer among African American men. Cancer causes & control : CCC 10 24801046
2022 Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice. Proceedings of the National Academy of Sciences of the United States of America 9 36442127
2022 New insights into the suppression of inflammation and lipid accumulation by JAZF1. Genes & diseases 9 37554201
2023 Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation. Nucleic acids research 8 36651297
2022 Down-regulation of the transcriptional repressor ZNF802 (JAZF1) reactivates fetal hemoglobin in β0-thalassemia/HbE. Scientific reports 8 35322124
2019 JAZF1-SUZ12 endometrial stromal sarcoma forming subserosal masses with extraordinary uptake of fluorodeoxyglucose on positron emission tomography: a case report. Diagnostic pathology 8 31615558
2023 Differential diagnosis of uterine adenosarcoma: identification of JAZF1-BCORL1 rearrangement by comprehensive cancer genomic profiling. Diagnostic pathology 7 36639698
2022 A novel CDKN1A-JAZF1 gene fusion in low-grade endometrial stromal sarcoma arising from endometriosis in abdominal wall cesarean section scar: A case report and literature review. Taiwanese journal of obstetrics & gynecology 7 36427980
2021 JAZF1 heterozygous knockout mice show altered adipose development and metabolism. Cell & bioscience 7 34407873
2021 RNA-driven JAZF1-SUZ12 gene fusion in human endometrial stromal cells. PLoS genetics 7 34928964
2023 JAZF1: A metabolic actor subunit of the NuA4/TIP60 chromatin modifying complex. Frontiers in cell and developmental biology 6 37091973
2021 Low-grade endometrial stromal sarcoma-like tumors in male with JAZF1 gene fusions. Genes, chromosomes & cancer 6 34651371
2022 JAZF1, YWHAE and BCOR gene translocation in primary extrauterine low-grade and high-grade endometrial stromal sarcomas. Histopathology 5 34843125
2022 Preparation of a JAZF1 protein polyclonal antibody and its potential role in broiler ascites syndrome. International journal of biological macromolecules 5 35245575
2016 [Endometrial stromal sarcoma: morphologic features and detection of JAZF1-SUZ12 and YWHAE FAM22 fusion genes]. Zhonghua bing li xue za zhi = Chinese journal of pathology 5 27142911
2014 Colonic low-grade endometrial stromal sarcoma and orthotopic endometrial stromal tumor with limited infiltration sharing the JAZF1-SUZ12 gene fusion. Pathology international 5 24750188
2010 Absence of the JAZF1/SUZ12 chimeric transcript in the immortalized non-neoplastic endometrial stromal cell line T HESCs. Oncology letters 5 22870092
2022 An Unusual Benign Uterine Stromal Spindle Cell Tumor Harboring JAZF1::BCORL1. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 4 35838627
2014 Prostate Cancer Related JAZF1 Gene is Associated with Schizophrenia. Journal of schizophrenia research 4 27570842
2023 Variants in JAZF1 are associated with asthma, type 2 diabetes, and height in the United Kingdom biobank population. Frontiers in genetics 3 37377600
2022 Cis-regulation of antisense non-coding RNA at the JAZF1 locus in type 2 diabetes. The journal of gene medicine 3 34978128
2021 Low-grade Endometrial Stromal Sarcoma With Sex Cord-like Differentiation and PHF1-JAZF1 Fusion With Deletions: A Diagnostic Pitfall of JAZF1 FISH. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 3 34074959
2020 Association of the JAZF1 Variant in Adults With a Parental History of Type 2 Diabetes Mellitus In Pakistan. Cureus 3 33425511
2016 [Effect of JAZF1 over-expression on high-fat diet-induced non-alcoholic fatty liver disease]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 3 27788707
2014 Association between KIAA0319L, PXK and JAZF1 gene polymorphisms and unexplained recurrent pregnancy loss in Chinese Han couples. Reproductive biomedicine online 3 25596907
2024 Identification of JAZF1, KNOP1, and PLEKHA1 as causally associated genes and drug targets for Alzheimer's disease: a summary data-based Mendelian randomization study. Inflammopharmacology 2 39455528
2023 JAZF1: A Metabolic Regulator of Sensitivity to a Polyamine-Targeted Therapy. Molecular cancer research : MCR 2 36166196
2015 [Effects of JAZF1 overexpression on proinflammatory cytokines in hepatocytes induced by palmitic acid]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2 26739470
2025 Spindle Cell Sarcoma With Novel JAZF1::NUDT5 Gene Fusion: Report of a Previously Undescribed Neoplasm. Genes, chromosomes & cancer 1 39873241
2017 [Values of JAZF1 gene rearrangement detected by fluorescence in-situ hybridization in diagnosis of endometrial stromal tumours]. Zhonghua bing li xue za zhi = Chinese journal of pathology 1 29136690
2025 Incidentally Discovered Intra-Abdominal Low-Grade Endometrioid Stromal Sarcoma Confirmed by JAZF1 Rearrangement Study. International journal of surgical pathology 0 40767152
2025 The study of JAZF1-mediated apoptosis of decidual stromal cells by activating the NF-κB signaling pathway in spontaneous preterm birth. BMC pregnancy and childbirth 0 40866818
2024 CircRNA ITCH Inhibits Epithelial-Mesenchymal Transformation and Promotes Apoptosis in Papillary Thyroid Carcinoma via miR-106a-5p/JAZF1 Axis. Biochemical genetics 0 38358587

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