Affinage

ITGB6

Integrin beta-6 · UniProt P18564

Length
788 aa
Mass
85.9 kDa
Annotated
2026-06-10
42 papers in source corpus 21 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ITGB6 encodes the β6 subunit of the epithelial integrin αvβ6, which binds and activates latent TGFβ1 at the cell surface and thereby couples cell-matrix engagement to TGFβ/Smad signaling (PMID:34621667). Its own transcription is driven by TGFβ1 through canonical Smad3/Smad4 binding to a single Smad element at promoter position -798, establishing an autocrine amplification loop in which αvβ6-mediated TGFβ1 activation sustains basal ITGB6 expression (PMID:27494713); SMAD4-dependent induction is recapitulated in pancreatic cancer, and ETS1 provides an alternative route to ITGB6 transcription in an acidic microenvironment (PMID:41424019, PMID:38316250). Downstream of ligand engagement, ITGB6 activates FAK/PI3K/AKT signaling to confer anoikis resistance and JAK/STAT3 signaling to drive EMT, migration, and invasion, with ITGB6 placed genetically upstream of these cascades by rescue and epistasis experiments (PMID:41022988, PMID:34268416, PMID:27508097). ITGB6 additionally shapes the tumor microenvironment: it activates fibroblasts and hepatic stellate cells to remodel the ECM and build a pro-metastatic niche (PMID:38205211, PMID:41424019), and regulates CX3CL1-mediated recruitment of macrophages that suppress CD8+ T-cell activity and limit immunotherapy response (PMID:39152118). The β6 subunit physically engages additional partners including PD-L1 (activating ITGB6/FAK signaling) and STC1 (activating PI3K signaling), and acts downstream of LAMC2 to relay ODAPH-driven TGFβ1/ALP signaling in ameloblast-lineage cells (PMID:30808674, PMID:35392966, PMID:40680053). Loss-of-function mutations in ITGB6 cause autosomal recessive amelogenesis imperfecta, reflecting a requirement for ITGB6-mediated cell-matrix interactions during ameloblast maturation (PMID:24305999, PMID:24319098).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1994 Medium

    Establishing the genomic position of ITGB6 within the integrin gene cluster anchored it physically next to its heterodimer partner ITGAV.

    Evidence FISH with GTG-banding and double-labeling FISH on human chromosomes

    PMID:7959743

    Open questions at the time
    • Mapping alone establishes no function
    • Does not address regulation or protein partners
  2. 2013 High

    Linking ITGB6 mutations to a Mendelian disease answered whether ITGB6 has a non-redundant physiological role, showing it is required for ameloblast-driven enamel formation.

    Evidence Whole-exome/Sanger sequencing of amelogenesis imperfecta families plus immunohistochemistry of mouse incisors, replicated across two papers

    PMID:24305999 PMID:24319098

    Open questions at the time
    • Does not define the matrix ligand engaged during amelogenesis
    • Mechanism connecting ITGB6 loss to enamel defect not fully resolved at the signaling level
  3. 2014 Medium

    Revealing that ITGB6 protein is undetectable in resting muscle despite mRNA presence and is induced post-transcriptionally upon injury established that ITGB6 is a context-induced, not constitutive, protein.

    Evidence Matched qRT-PCR, western blot, and IHC in injured vs uninjured mouse skeletal muscle with temporal kinetics

    PMID:24488487

    Open questions at the time
    • Mechanism of post-transcriptional control not identified
    • Functional consequence in muscle repair not tested
  4. 2016 High

    Defining how ITGB6 transcription is controlled answered whether the integrin's TGFβ-activating output feeds back on its own expression, establishing a Smad3/Smad4 autocrine amplification loop.

    Evidence ChIP, promoter reporter with Smad-site mutation, dominant-negative Smad3/4, and adenoviral TGFβ1 mouse model; plus miRNA-driven TGFβR2/SARA epistasis placing ITGB6 downstream of TGFβ/Smad2-3

    PMID:27494713 PMID:27508097

    Open questions at the time
    • Single Smad site characterized; other regulatory inputs not mapped
    • Loop kinetics and thresholds for amplification not defined
  5. 2021 Medium

    Demonstrating that ITGB6 binds and activates latent TGFβ1 to trigger Smad3-driven EMT connected the integrin's matrix-binding role to a defined invasion-promoting transcriptional program.

    Evidence Anti-ITGB6 blocking, dual-luciferase reporter, ELISA, and EMT marker western blots in ovarian cancer 3D spheroids; SMYD3 positive feedback loop

    PMID:34621667

    Open questions at the time
    • Single lab; structural basis of latent TGFβ1 engagement not resolved
    • In vivo confirmation limited
  6. 2021 Medium

    Genetic and epistasis experiments placed ITGB6 upstream of distinct effector cascades — PODXL2, JAK/STAT3, and STAT1 — and downstream of TGFβ, defining the signaling architecture around the integrin.

    Evidence CRISPR KO with RNA-seq (PODXL2) in cholangiocarcinoma; siRNA plus JAK/STAT3 activator rescue in cervical carcinoma; intestinal epithelial ITGB6 transgenic mouse with STAT1 readout in DSS colitis

    PMID:33491282 PMID:34208313 PMID:34268416

    Open questions at the time
    • Each link shown in a single tumor/tissue context
    • Direct physical coupling between ITGB6 and these kinases not demonstrated
  7. 2022 Medium

    Identifying STC1 as a direct ITGB6 partner activating PI3K, and HAX1-driven translational upregulation of ITGB6, expanded the inputs that elevate ITGB6 activity beyond transcription.

    Evidence Co-IP (STC1/ITGB6) with functional assays in ovarian cancer; ribosome profiling and EV transfer with in vivo angiogenesis/metastasis models for HAX1

    PMID:35392966 PMID:35524442

    Open questions at the time
    • Reciprocal validation of STC1/ITGB6 binding limited
    • Translational control mechanism by HAX1 not molecularly resolved
  8. 2023 Medium

    Showing that exosomal ITGB6 transferred to fibroblasts converts them into cancer-associated fibroblasts established a non-cell-autonomous, microenvironment-remodeling function for the integrin.

    Evidence Exosome isolation/transfer, recipient fibroblast RNA-seq, exosomal proteomics, and CAF activation assays in lung adenocarcinoma

    PMID:38205211

    Open questions at the time
    • Mechanism of ITGB6 packaging into exosomes unknown
    • KLF10 feedback loop dissection incomplete
  9. 2024 Medium

    Linking ITGB6 to CX3CL1-driven macrophage recruitment and CD8+ T-cell suppression connected the integrin to immune evasion and immunotherapy resistance.

    Evidence scRNA-seq, ITGB6 KO immunocompetent mouse models, and CX3CL1-CX3CR1 axis inhibition restoring anti-CD276/anti-PD1 sensitivity

    PMID:39152118

    Open questions at the time
    • How ITGB6 regulates CX3CL1 transcriptionally not defined
    • Single lab; human relevance from mouse models not confirmed
  10. 2025 Medium

    Multiple 2025 studies consolidated ITGB6's roles in FAK/PI3K/AKT-mediated anoikis resistance, SMAD4-dependent transcription with a stellate-cell pro-fibrotic niche, and as an obligate LAMC2-to-TGFβ1 mediator in ameloblasts.

    Evidence RNA-seq/in vivo metastasis models (FAK/PI3K/AKT anoikis); ChIP-qPCR, reporter, and therapeutic monoclonal antibody xenograft (SMAD4/HSC niche); Co-IP and CWHM-12 integrin-inhibitor rescue (LAMC2/ODAPH/TGFβ1/ALP)

    PMID:40680053 PMID:41022988 PMID:41424019

    Open questions at the time
    • Each mechanism shown in a single model system
    • Therapeutic antibody efficacy not extended beyond mouse models

Open questions

Synthesis pass · forward-looking unresolved questions
  • Whether the diverse downstream cascades (FAK/PI3K/AKT, JAK/STAT3, STAT1) and physical partners (PD-L1, STC1, LAMC2) reflect a single unified ITGB6 signaling mechanism or context-specific outputs remains unresolved.
  • No structural model of ITGB6 partner-binding interfaces
  • No cross-context comparison of which effectors dominate in which tissue
  • Mechanism converting matrix engagement into distinct kinase outputs unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 3 GO:0098631 cell adhesion mediator activity 2 GO:0098772 molecular function regulator activity 1
Localization
GO:0005886 plasma membrane 2
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1474244 Extracellular matrix organization 2 R-HSA-168256 Immune System 2 R-HSA-1643685 Disease 1
Partners
ITGAVLAMC2PD-L1STC1TGFB1
Complex memberships
αvβ6 integrin

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 TGFβ1 upregulates ITGB6 gene transcription via canonical Smad3/Smad4 signaling: ChIP demonstrated direct binding of Smad3 and Smad4 to the ITGB6 promoter at a single Smad binding site at position -798, and dominant-negative Smad3/4 constructs abolished TGFβ1-induced ITGB6 transcriptional activity. A homeostatic autocrine loop exists where αvβ6-mediated TGFβ1 activation drives basal ITGB6 expression, which can be amplified by exogenous TGFβ1. In vivo, Smad3 was required for TGFβ1-induced αvβ6 integrin expression in alveolar epithelium. Dominant-negative Smad3/4 constructs, ITGB6 promoter reporter assays with Smad-binding-site mutation, chromatin immunoprecipitation (ChIP), adenoviral TGFβ1 overexpression mouse model PloS one High 27494713
2013 Loss-of-function mutations in ITGB6 (missense and nonsense variants in the βI-domain and elsewhere) cause autosomal recessive amelogenesis imperfecta. Immunohistochemistry localized ITGB6 protein to the distal membrane of differentiating ameloblasts/pre-ameloblasts, with internalization in secretory-stage ameloblasts and strongest expression at the maturation stage, indicating that ITGB6-mediated cell-matrix interactions are required at multiple stages of amelogenesis. Whole-exome sequencing, Sanger sequencing, immunohistochemistry of mouse mandibular incisors Human molecular genetics High 24305999 24319098
2019 PD-L1 directly interacts with integrin β6 (ITGB6) and activates the ITGB6/FAK signaling pathway. RORC negatively regulates PD-L1 expression by binding to its promoter, thereby suppressing PD-L1/ITGB6 signaling and preventing nuclear translocation of STAT3 in bladder cancer cells. Co-immunoprecipitation (PD-L1/ITGB6 interaction), chromatin immunoprecipitation (RORC on PD-L1 promoter), western blotting, in vitro and in vivo functional assays Cancer research Medium 30808674
2021 In ovarian cancer spheroids, ITGB6 binds latent TGFβ1 (confirmed by anti-ITGB6 antibody inhibition and dual-luciferase reporter assays), activates it, and triggers downstream TGFβ1/Smad3 signaling to induce EMT markers (N-cadherin, Snail, Vimentin upregulation; E-cadherin downregulation). SMYD3 promotes ITGB6 expression and TGFβ1 release from spheroids, and TGFβ1 feeds back to upregulate SMYD3 and ITGB6, forming a positive feedback loop that drives invasion and adhesion. Anti-ITGB6 antibody blocking assays, dual-luciferase reporter assays, ELISA, western blotting, Transwell invasion/adhesion assays, 3D spheroid models Frontiers in oncology Medium 34621667
2022 STC1 (Stanniocalcin 1) directly binds to ITGB6 to activate the PI3K signaling pathway, promoting metastasis, lipid metabolism, and cisplatin chemoresistance in ovarian cancer. STC1 is transcriptionally regulated by FOXC2, placing ITGB6 downstream in the FOXC2/STC1/ITGB6/PI3K axis. Co-immunoprecipitation (STC1/ITGB6 direct binding), in vitro and in vivo functional assays, western blotting Journal of experimental & clinical cancer research : CR Medium 35392966
2022 HAX1, delivered via extracellular vesicles (EVs) to endothelial cells, enhances the translational efficiency of ITGB6 mRNA (identified by ribosome profiling), increasing ITGB6 protein levels and activating the FAK pathway, thereby promoting angiogenesis and NPC metastasis. Ribosome profiling, in vitro EV uptake assays, in vivo angiogenesis and metastasis models, western blotting Journal of extracellular vesicles Medium 35524442
2014 ITGB6 protein expression in skeletal muscle is post-transcriptionally regulated: uninjured muscle expresses Itgb6 mRNA but no detectable ITGB6 protein; muscle injury rapidly induces ITGB6 protein accumulation in myofibers adjacent to the injury site, persisting in newly formed fibers through at least 15 days post-injury. qRT-PCR, western blotting, immunohistochemistry in injured and uninjured mouse skeletal muscle Journal of molecular histology Medium 24488487
2021 ITGB6 knockout in cholangiocarcinoma (HuCCT1) cells using CRISPR/Cas9 significantly inhibited cell migration, invasion, wound healing, colony formation, and caused cell cycle dysregulation. RNA sequencing identified a marked decrease in PODXL2 (podocalyxin-like protein 2) expression in ITGB6-KO cells, and co-localization of ITGB6 and PODXL2 was observed by immunofluorescence, placing PODXL2 downstream of ITGB6. CRISPR/Cas9 knockout, RNA sequencing, flow cytometry, immunofluorescence co-localization, migration/invasion assays International journal of molecular sciences Medium 34208313
2021 Silencing of ITGB6 in cervical carcinoma cells suppresses JAK1, JAK2, and STAT3 phosphorylation, reduces EMT marker expression (Snail, Vimentin, N-cadherin), and increases E-cadherin. Reactivation of the JAK/STAT3 pathway with an activator (RO8191) reversed the effects of ITGB6 silencing on proliferation, migration, invasion, and EMT markers, placing ITGB6 upstream of JAK/STAT3 signaling. siRNA knockdown, western blotting, JAK/STAT3 pathway activator rescue experiment, Transwell and wound-healing assays Annals of translational medicine Medium 34268416
2021 Transgenic overexpression of ITGB6 specifically in intestinal epithelial cells exacerbated DSS-induced colitis in mice, associated with increased macrophage infiltration, pro-inflammatory cytokine secretion, increased integrin ligand expression, and activation of the STAT1 signaling pathway. Intestinal epithelial cell-specific ITGB6 transgenic mouse model, DSS colitis induction, histopathology, cytokine measurement, western blotting Journal of cellular and molecular medicine Medium 33491282
2016 miR-17 and miR-20a target TGFβR2 and SARA (components of the TGFβ pathway), reducing Smad2/3 phosphorylation and thereby decreasing ITGB6 expression, which impedes ESCC cell migration and invasion. This epistasis places ITGB6 as a downstream effector of TGFβ/Smad2-3 signaling in ESCC motility. miRNA overexpression, luciferase reporter assays (for TGFBR2 and SARA as targets), TGFβ treatment/rescue experiments, in vitro migration/invasion assays, in vivo pulmonary arrest model American journal of cancer research Medium 27508097
2023 Exosomal ITGB6 from dormant lung adenocarcinoma cells is transferred into fibroblasts, where it activates a KLF10 positive feedback loop and the TGFβ pathway, converting normal fibroblasts into cancer-associated fibroblasts (CAFs) and promoting ECM remodeling. Exosome isolation and transfer assays, RNA-seq of recipient fibroblasts, exosomal proteomics, functional CAF activation assays Translational lung cancer research Medium 38205211
2024 ITGB6 regulates tumor-associated chemokine CX3CL1 expression in head and neck squamous cell carcinoma; ITGB6-expressing tumors recruit PF4+ macrophages expressing high CX3CR1 via CX3CL1. These macrophages secrete CXCL16 to suppress CXCR6+ CD8+ T cell activity. Inhibition of CX3CL1-CX3CR1 axis or ITGB6 knockout restored sensitivity to anti-CD276 and anti-PD1 therapies. Single-cell RNA sequencing, ITGB6 gene-knockout mouse models, chemically-induced and orthotopic carcinogenesis models, CX3CL1-CX3CR1 axis inhibition Nature communications Medium 39152118
2025 ITGB6 promotes anoikis resistance in daughter cells of polyploid giant cancer cells (PGCCs) in HNSCC by activating the FAK/PI3K/AKT signaling pathway, facilitating tumor recurrence and metastasis. In vitro and in vivo experiments confirmed that ITGB6 upregulation in these daughter cells suppresses anoikis via this pathway. RNA-seq, in vitro anoikis assays, in vivo metastasis models, western blotting for FAK/PI3K/AKT pathway markers Scientific reports Medium 41022988
2025 TGFβ upregulates ITGB6 expression through a SMAD4-dependent pathway (confirmed by ChIP-qPCR and dual-luciferase reporter assays). Elevated ITGB6 promotes pancreatic cancer cell migration/invasion and activates hepatic stellate cells (HSCs) to create a pro-fibrotic metastatic niche. An ITGB6 monoclonal antibody significantly attenuated HSC activation and suppressed liver metastasis formation in mouse models. ChIP-qPCR, dual-luciferase reporter assay, subcutaneous and liver metastasis xenograft models, ELISA, western blotting, monoclonal antibody intervention Chinese medical journal Medium 41424019
2025 ODAPH interacts directly with Lamininγ2 (LAMC2), confirmed by co-immunoprecipitation. ODAPH overexpression enhances the LAMC2/ITGB6/TGFβ1/ALP signaling pathway in ameloblast-lineage cells. ITGB6 activates the TGFβ1/ALP cascade, and inhibition of integrin with CWHM-12 abrogates ODAPH-mediated TGFβ1/ALP induction, placing ITGB6 as an obligate mediator between LAMC2 and TGFβ1 signaling in ameloblast adhesion and mineralization. Co-immunoprecipitation (ODAPH-LAMC2), overexpression in ameloblast-lineage cells, integrin inhibitor (CWHM-12) rescue experiment, western blotting PloS one Medium 40680053
2024 ETS1 transcription factor directly binds the ITGB6 promoter and promotes its transcription in an acidic tumor microenvironment. ChIP-qPCR demonstrated ETS1 enrichment at the ITGB6 promoter, and dual-luciferase reporter assays confirmed ETS1-mediated transcriptional activation of ITGB6. Acidity-induced ITGB6 expression then activates EMT and focal adhesion signaling pathways to promote NSCLC cell migration and invasion. ChIP-qPCR, dual-luciferase reporter assay, ITGB6 knockdown rescue experiments, migration/invasion assays Experimental cell research Medium 38316250
1994 The human ITGB6 gene was regionally localized to chromosome 2q24-q31 by fluorescence in situ hybridization (FISH) with GTG-banding. Double-labeling FISH showed ITGB6 is located proximal to ITGAV on this integrin gene cluster. Fluorescence in situ hybridization (FISH) with GTG-banding, double-labeling FISH Genomics Medium 7959743
2024 CRISPR/Cas9 knockout of ITGB6 in human OSCC cells (HN cell line) significantly reduced cell migration and proliferation, establishing ITGB6 as required for these behaviors in oral squamous cell carcinoma. CRISPR/Cas9 knockout, MTT proliferation assay, scratch migration assay, Sanger sequencing, FACS verification Head & face medicine Low 38890650
2025 ITGB6 knockout in porcine intestinal epithelial cells (IPEC-J2) significantly reduced DON-induced reactive oxygen species levels and cell apoptosis. Transcriptomic analysis of ITGB6-KO cells after DON treatment showed differential gene enrichment in the PI3K/AKT signaling pathway, implicating ITGB6 in PI3K/AKT-mediated cell survival/apoptosis under toxin exposure. CRISPR/Cas9 knockout, ROS measurement, flow cytometry apoptosis assay, transcriptomic analysis Toxicology Low 41161376

Source papers

Stage 0 corpus · 42 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2019 Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer. Cancer research 112 30808674
2022 Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer. Journal of experimental & clinical cancer research : CR 78 35392966
2013 ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta. Human molecular genetics 56 24305999
2013 A missense mutation in ITGB6 causes pitted hypomineralized amelogenesis imperfecta. Human molecular genetics 48 24319098
2016 Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis. PloS one 41 27494713
2022 Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation. Journal of extracellular vesicles 38 35524442
2019 The ITGB6 gene: its role in experimental and clinical biology. Gene: X 37 32550552
2019 The ITGB6 gene: its role in experimental and clinical biology. Gene 37 34493369
2021 Silencing of ITGB6 inhibits the progression of cervical carcinoma via regulating JAK/STAT3 signaling pathway. Annals of translational medicine 33 34268416
2024 ITGB6 modulates resistance to anti-CD276 therapy in head and neck cancer by promoting PF4+ macrophage infiltration. Nature communications 30 39152118
2023 Exploring the role of ITGB6: fibrosis, cancer, and other diseases. Apoptosis : an international journal on programmed cell death 25 38127283
2010 Severe pulmonary emphysema in a girl with interstitial deletion of 2q24.2q24.3 including ITGB6. American journal of medical genetics. Part A 24 20358620
2016 MicroRNA-17/20a impedes migration and invasion via TGF-β/ITGB6 pathway in esophageal squamous cell carcinoma. American journal of cancer research 23 27508097
2023 Exosomal ITGB6 from dormant lung adenocarcinoma cells activates cancer-associated fibroblasts by KLF10 positive feedback loop and the TGF-β pathway. Translational lung cancer research 22 38205211
2022 Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells. Cancer biology & therapy 17 35188070
2021 A SMYD3/ITGB6/TGFβ1 Positive Feedback Loop Promotes the Invasion and Adhesion of Ovarian Cancer Spheroids. Frontiers in oncology 17 34621667
2015 Genetic variants in the ITGB6 gene is associated with the risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 14 26449830
1994 Regional localization of the human integrin beta 6 gene (ITGB6) to chromosome 2q24-q31. Genomics 13 7959743
2021 ITGB6-Knockout Suppresses Cholangiocarcinoma Cell Migration and Invasion with Declining PODXL2 Expression. International journal of molecular sciences 12 34208313
2014 Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscle. Journal of molecular histology 12 24488487
2025 Jiawei yanghe decoction alleviates osteoporotic osteoarthritis by promoting MSC osteogenic differentiation and homing via ITGB6/TGF-β/CXCR4 pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology 11 40929885
2014 Development of a tetra-primer ARMS PCR-based assay for detection of a novel single-nucleotide polymorphism in the 5' untranslated region of the bovine ITGB6 receptor gene associated with foot-and-mouth disease susceptibility in cattle. Archives of virology 11 25078391
2023 Novel ITGB6 variants cause hypoplastic-hypomineralized amelogenesis imperfecta and taurodontism: characterization of tooth phenotype and review of literature. BDJ open 9 37041139
2021 Transgenic overexpression of ITGB6 in intestinal epithelial cells exacerbates dextran sulfate sodium-induced colitis in mice. Journal of cellular and molecular medicine 9 33491282
2015 Novel ITGB6 mutation in autosomal recessive amelogenesis imperfecta. Oral diseases 7 25431241
2021 ITGB6 may promote proliferation and invasion in pancreatic cancer. Archives of medical science : AMS 6 38414469
2024 Acidity-induced ITGB6 promote migration and invasion of lung cancer cells by epithelial-mesenchymal transition and focal adhesion. Experimental cell research 5 38316250
2021 ITGB6 inhibits the proliferation of porcine skeletal muscle satellite cells. Cell biology international 5 34519117
2025 ITGB6 promotes tumor recurrence and metastasis by mediating the resistance of daughter cells of PGCCs to anoikis : ITGB6 promotes tumor recurrence and metastasis via Anoikis resistance. Scientific reports 4 41022988
2015 Heterozygosity at the SNP (rs136500299) of ITGB6 receptor gene possibly influences the susceptibility among crossbred bull to foot and mouth disease infection. Virusdisease 4 26436121
2024 ITGB6 promotes pancreatic fibrosis and aggravates the malignant process of pancreatic cancer via JAK2/STAT3 signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology 3 38418753
2025 Odontogenesis-associated phosphoprotein (ODAPH) Promotes Ameloblast adhesion and alkaline phosphatase (ALP) expression via LAMC2/ ITGB6/TGF-β1 signaling pathway. PloS one 2 40680053
2024 CRISPR/Cas9-mediated knock out of ITGB6 in human OSCC cells reduced migration and proliferation ability. Head & face medicine 2 38890650
2015 Single tube tetraplex PCR based screening of a SNP at exon 14 region of bovine ITGB6 among different Zebu breeds. Meta gene 2 25685717
2024 LncRNA SSTR5-AS1 promotes esophageal carcinoma through regulating ITGB6/JAK1/STAT3 signaling. Epigenomics 1 39234955
2023 Upregulation of ITGB6 in primary palmar hyperhidrosis. Advances in clinical and experimental medicine : official organ Wroclaw Medical University 1 37212774
2026 Novel ITGB6 Mutations Causing Amelogenesis Imperfecta. Genes 0 42074549
2025 SPP1 + macrophages facilitate pancreatic cancer progression via ITGB6-mediated interactions: evidence from integrated multi-omics analysis and experimental validation. Immunologic research 0 40719841
2025 Analysis of the expression and function of ITGB6 in porcine intestinal epithelial cells upon deoxynivalenol exposure. Toxicology 0 41161376
2025 The cuproptosis-related gene ITGB6 and LTBP1 may be associated with diabetic kidney disease progression and immune cell infiltration. PeerJ 0 41244197
2025 Effect of TGFβ-ITGB6 feedback loop on liver metastasis in SMAD4 wild-type pancreatic cancer. Chinese medical journal 0 41424019
2025 Inhibition of ITGB6 stimulates potent anti-tumor responses in immunocompetent mouse models of head and neck squamous cell carcinoma and pancreatic adenocarcinoma. American journal of cancer research 0 41523261

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