Affinage

ITGAE

Integrin alpha-E · UniProt P38570

Length
1179 aa
Mass
130.2 kDa
Annotated
2026-04-28
100 papers in source corpus 15 papers cited in narrative 15 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ITGAE encodes the αE integrin subunit (CD103) that pairs with β7 to form the αEβ7 heterodimer, a key adhesion receptor on intraepithelial and tissue-resident memory (TRM) T cells that binds E-cadherin on epithelial cells to mediate lymphocyte retention within epithelial compartments (PMID:10978890, PMID:34861219). CD103 expression is transcriptionally induced by TGF-β signaling through Smad2/3 cooperating with NFAT-1 at the ITGAE promoter/enhancer, positively regulated by Runx3, and repressed by Gfi-1 binding at intron 1 and by Tcf1 binding at the Itgae locus (PMID:14688328, PMID:24477908, PMID:16034110, PMID:19188499, PMID:32268106). Upon E-cadherin engagement, the αE cytoplasmic tail recruits paxillin in an S1163-dependent manner, triggering Pyk2 phosphorylation, CCR5 polarization to the immunological synapse, and extracellular granzyme release that drives cytotoxic effector functions including epithelial cell shedding and tumor suppression (PMID:29021139, PMID:19638592, PMID:34861219, PMID:33515805). CD103+ TRM cells contribute to tissue immunosurveillance and, when dysregulated, to autoimmune tissue damage in organs such as salivary glands, where anti-CD103 blockade reduces glandular injury (PMID:38777379).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2000 Medium

    Establishing that αEβ7 integrin binds E-cadherin as its cognate ligand provided the molecular basis for how intraepithelial T cells are retained within epithelial tissues.

    Evidence Review synthesizing binding studies and adhesion assays characterizing αEβ7/E-cadherin interaction

    PMID:10978890

    Open questions at the time
    • Mechanistic details of how E-cadherin engagement triggers intracellular signaling were unknown
    • No structural model of the αEβ7/E-cadherin interface
  2. 2004 High

    Demonstrating that TGF-β signaling at peripheral tissue sites is the dominant inducer of CD103 on CD8+ effector T cells resolved how tissue microenvironmental cues program integrin expression after T cell entry.

    Evidence Adoptive transfer of CD8 T cells expressing dominant-negative TGF-β receptor into mouse renal allografts with flow cytometric analysis

    PMID:14688328

    Open questions at the time
    • Downstream transcription factors mediating TGF-β-driven CD103 induction not yet identified
    • Whether autocrine vs. paracrine TGF-β was responsible remained unclear
  3. 2005 High

    Identifying Runx3 as a transcription factor necessary for CD103 induction during thymic CD8 T cell development connected lineage-specific transcriptional programs to integrin αE expression.

    Evidence Runx3 knockout and transgenic overexpression mice with flow cytometric analysis of thymocyte CD103 expression

    PMID:16034110

    Open questions at the time
    • Whether Runx3 binds the Itgae locus directly was not shown
    • Relationship between Runx3-dependent thymic induction and peripheral TGF-β-driven induction was unclear
  4. 2009 High

    Two parallel advances resolved both a transcriptional repression mechanism and a functional consequence of CD103 ligation: Gfi-1 was shown to directly repress Cd103 via intron 1 binding with LSD1-mediated histone demethylation, while CD103/E-cadherin engagement was found to recruit CCR5 to the immunological synapse, explaining how CD103 promotes T cell retention by desensitizing cells to chemotactic gradients.

    Evidence Gfi-1 KO mice and ChIP for Gfi-1/LSD1 at Cd103 intron 1 with histone modification analysis; in vivo adoptive transfer into NOD/SCID mice bearing tumors with synapse imaging for CCR5 polarization

    PMID:19188499 PMID:19638592

    Open questions at the time
    • Whether CCR5 recruitment required cytoplasmic tail signaling or was adhesion-dependent remained unknown
    • Relative contribution of Gfi-1 repression vs. positive TGF-β induction in setting CD103 expression levels was not quantified
  5. 2014 High

    Mapping the human ITGAE promoter/enhancer and identifying cooperative Smad2/3-NFAT-1 transcription factor binding explained how TGF-β and TCR co-stimulation converge to activate CD103 transcription.

    Evidence Reporter assays with ITGAE regulatory elements, Smad2/3 and NFAT-1 overexpression/knockdown in human CTL clones

    PMID:24477908

    Open questions at the time
    • Chromatin accessibility dynamics at the ITGAE locus during activation were not characterized
    • Whether additional co-activators participate in the Smad2/3-NFAT-1 complex was unknown
  6. 2017 High

    Identification of paxillin as a direct binding partner of the αE cytoplasmic tail, dependent on serine 1163, revealed the outside-in signaling pathway through which E-cadherin engagement drives T cell adhesion, spreading, and cytotoxic granule release.

    Evidence Co-immunoprecipitation of paxillin with αE tail, S1163 mutagenesis, shRNA knockdown of paxillin, functional assays in Jurkat cells and primary TILs

    PMID:29021139

    Open questions at the time
    • Kinase responsible for S1163 phosphorylation not identified
    • Whether paxillin recruitment is sufficient or requires additional adaptor proteins was not resolved
  7. 2019 Medium

    Discovery that CD103+ CTLs produce autocrine TGF-β1 to self-maintain CD103 expression showed that tissue-resident T cells can sustain their own residency program independently of stromal TGF-β sources.

    Evidence TGF-β1 blocking studies on TCR-matched CD103+ vs. CD103− cancer-specific CTL clones with functional cytotoxicity assays

    PMID:31771983

    Open questions at the time
    • Extent of autocrine vs. paracrine TGF-β contribution in vivo not quantified
    • Mechanism by which CD103 enhances TCR antigen sensitivity was not defined
  8. 2020 High

    Demonstrating that Tcf1 directly binds and represses the Itgae locus identified a second transcriptional repressor and established a reciprocal regulatory axis between Tcf1-dependent stemness and CD103-dependent tissue residency.

    Evidence ChIP for Tcf1 at Itgae locus, T-cell-specific Tcf7 conditional KO mice, flow cytometry for CD103 and TRM numbers

    PMID:32268106

    Open questions at the time
    • Whether Tcf1 and Gfi-1 act on the same or distinct regulatory elements was not compared
    • Epigenetic state changes upon Tcf1 loss at the Itgae locus were not characterized
  9. 2021 High

    Genetic and antibody blockade studies in the intestine established that CD103/E-cadherin interaction is functionally required for both γδ IEL-mediated epithelial cell shedding via perforin-independent granzyme release and IEL-dependent suppression of intestinal tumorigenesis.

    Evidence CD103 KO mice, anti-CD103 blocking antibody, intravital microscopy, granzyme ELISA from γδ IELs, APCmin tumor model with organoid co-culture

    PMID:33515805 PMID:34861219

    Open questions at the time
    • Molecular mechanism linking CD103 ligation to granzyme exocytosis (perforin-independent) was not elucidated
    • Whether CD103 signals differently in γδ vs. αβ IELs was not addressed
  10. 2022 High

    Linking NUDT1 to CD103+ TRM longevity through PARP1-TGFβR-dependent DNA damage resistance revealed a metabolic checkpoint that maintains TGF-β-Smad signaling and thereby sustains CD103 expression and tissue residency.

    Evidence NUDT1 conditional KO and overexpression in CD8+ T cells, PARP1 inhibition, adoptive co-transfer in murine cholangitis model

    PMID:35753523

    Open questions at the time
    • Whether NUDT1 acts on the Itgae locus directly or exclusively through TGFβR maintenance was not resolved
    • Generalizability beyond hepatic TRM was not tested
  11. 2023 High

    Two studies expanded understanding of upstream signals: retinoic acid during mesenteric lymph node priming was shown to license intestinal CD103+ TRM differentiation independently of gut homing, and 4-octyl itaconate was found to suppress CD103+ TRM induction by blocking RUNX3 DNA demethylation.

    Evidence Retinoic acid blockade and MLN vs. spleen priming comparison in mice; 4-OI treatment with RUNX3 methylation analysis in CD8 T cells and murine PSC models

    PMID:36809399 PMID:37505225

    Open questions at the time
    • Epigenetic regulation of Runx3 at the Itgae locus vs. Runx3 target genes was not distinguished
    • Whether retinoic acid acts on Itgae chromatin directly or indirectly through Runx3/Smad axis was not defined
  12. 2024 High

    Therapeutic blockade of CD103 in a Sjögren's disease model demonstrated that CD103+ TRM cells are pathogenic effectors in autoimmune glandular destruction, establishing CD103 as a potential therapeutic target in tissue-localized autoimmunity.

    Evidence Anti-CD103 monoclonal antibody intraglandular administration in ESS mouse model with functional salivary flow measurement, scRNAseq, granzyme B/IFN-γ immunostaining

    PMID:38777379

    Open questions at the time
    • Whether CD103 blockade depletes TRM cells or merely disrupts retention was not mechanistically distinguished
    • Long-term consequences of CD103 blockade on mucosal immunity were not assessed

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the structural basis of the αEβ7/E-cadherin interface, the kinase(s) responsible for S1163 phosphorylation on the αE cytoplasmic tail, how CD103 ligation triggers perforin-independent granzyme release, and the integrated epigenetic logic governing Runx3/Gfi-1/Tcf1 at the Itgae locus.
  • No crystal structure of αEβ7/E-cadherin complex
  • Kinase for S1163 phosphorylation unidentified
  • Mechanism of perforin-independent granzyme release downstream of CD103 unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098631 cell adhesion mediator activity 5
Localization
GO:0005886 plasma membrane 5
Pathway
R-HSA-1500931 Cell-Cell communication 4 R-HSA-162582 Signal Transduction 4 R-HSA-168256 Immune System 4
Partners
CCR5CDH1ITGB7NFATC2PTK2BPXNSMAD2SMAD3
Complex memberships
αEβ7 integrin heterodimer

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 αE(CD103)β7 integrin binds E-cadherin on epithelial cells, mediating T cell localization to epithelial compartments; this interaction was characterized as the key adhesive mechanism for intraepithelial T cell retention. Review synthesizing binding studies and adhesion assays Current opinion in cell biology Medium 10978890
2004 TGF-β signaling at the graft site is the dominant factor driving CD103 upregulation on CD8+ effector T cells after migration into renal allografts; CD8 cells expressing dominant-negative TGF-β receptor showed markedly deficient CD103 expression. Nonvascularized mouse renal allograft model, adoptive transfer of TCR-transgenic CD8 T cells expressing dominant-negative TGF-β receptor, three-color flow cytometry Journal of immunology High 14688328
2005 The transcription factor Runx3 is necessary for CD103 (integrin αE) induction during development of CD8 single-positive thymocytes; Runx3 deletion reduces CD103 expression, and Runx3 overexpression upregulates CD103 on CD4 SP T cells. Runx3 knockout mice, Runx3 transgenic overexpression mice, flow cytometry analysis of thymocyte subsets Journal of immunology High 16034110
2009 Intratumoral co-engagement of TCR and TGF-β1 receptor triggers CD103 expression on CD8+ T cells, and CD103/E-cadherin interaction recruits CCR5 to the immunological synapse, inhibiting T cell sensitivity to CCL5 chemotactic gradient and promoting T cell retention at the tumor site. Adoptive transfer of PBL clone into NOD/SCID mice bearing cognate tumor, flow cytometry for CD103 induction, immunological synapse analysis for CCR5 recruitment Cancer research High 19638592
2009 TGF-β represses the transcriptional repressor Gfi-1, and Gfi-1 directly binds intron 1 of Cd103 to repress its expression; loss of Gfi-1 allows histone H3K4me3 marks at the Cd103 locus and promotes CD103+ iTreg differentiation. Gfi-1 knockout mice, ChIP showing Gfi-1-LSD1 complex binding to Cd103 intron 1, histone modification analysis, enforced Gfi-1 expression The Journal of experimental medicine High 19188499
2014 The transcription factors Smad2/3 and NFAT-1 cooperatively regulate ITGAE (CD103) gene transcription in human CD8 T cells; promoter and enhancer elements of the human ITGAE gene responsive to TGF-β1/TCR co-stimulation were identified. Human CTL clone model, reporter assays with ITGAE promoter/enhancer elements, Smad2/3 and NFAT-1 overexpression/knockdown Journal of immunology High 24477908
2017 Paxillin (Pxn) binds the cytoplasmic tail of the αE/CD103 subunit upon engagement with E-cadherin; this triggers phosphorylation of Pxn and Pyk2, and serine residue S1163 of the αE chain intracellular domain is required for CD103 polarization and lysosome/Pxn recruitment at the contact zone, driving CD8+ T cell adhesion, spreading, and cytotoxic effector functions. Co-immunoprecipitation of Pxn with αE/CD103 cytoplasmic tail, shRNA knockdown of Pxn, Src inhibitor saracatinib, mutagenesis of S1163, Jurkat T cell model with rE-cadherin-Fc-coated beads, freshly isolated tumor-infiltrating lymphocytes Cancer research High 29021139
2020 T cell factor 1 (Tcf1) directly binds the Itgae (CD103) locus and inhibits TGF-β-induced CD103 expression; T-cell-specific Tcf7 ablation enhances CD103 protein expression in TRM cells and increases TRM cell numbers, demonstrating reciprocal regulation between Tcf1 and CD103 in tissue residency programming. ChIP showing Tcf1 binding to Itgae locus, T-cell-specific Tcf7 conditional knockout mice, TGF-β signaling abrogation experiments, flow cytometry for CD103 expression Cell reports High 32268106
2019 CD103+ cancer-specific CTLs express and secrete active TGF-β1 in an autocrine manner to continuously self-regulate CD103 expression, without relying on external TGF-β1-producing cells; CD103 expression on CTLs improves TCR antigen sensitivity enabling faster cancer recognition. TCR-matched CD103+ and CD103- cancer-specific CTL clones, in vitro TGF-β1 blocking, functional cytotoxicity assays, migration assays Cancer immunology research Medium 31771983
2021 CD103 engagement by E-cadherin on enterocytes is required for γδ intraepithelial lymphocyte-mediated apoptotic cell shedding; CD103 ligation triggers extracellular granzyme A and B release from γδ IELs (without requiring perforin), and CD103 knockout or blockade significantly reduces LPS-induced epithelial cell shedding. Intravital microscopy in GFP γδ T cell reporter mice, CD103 knockout mice, anti-CD103 blocking antibody, granzyme A/B ELISA from ex vivo-stimulated γδ IELs, immunostaining for cleaved caspase-3 Gastroenterology High 34861219
2021 Intraepithelial lymphocytes suppress intestinal tumor growth through CD103/E-cadherin-dependent cell-to-cell contact; genetic deletion of CD103 decreased IEL-epithelial cell interaction frequency and increased small intestinal tumor numbers, and wild-type IELs reduced viability of tumor organoids in a CD103-dependent manner. DPE-GFP × APCmin mice, CD103 knockout mice, in vivo live-imaging system, in vitro co-culture with intestinal tumor organoids, tumor counting Cellular and molecular gastroenterology and hepatology High 33515805
2022 NUDT1 promotes CD103+ TRM cell accumulation and longevity through PARP1-TGFβR axis-dependent DNA damage resistance; NUDT1-dependent signaling maintains TGF-β-Smad signaling required for tissue residency programming, and pharmacological blockade or genetic deletion of NUDT1 eliminates CD103+ TRM cells and alleviates cholangitis in mice. NUDT1 conditional knockout mice, NUDT1 overexpression in CD8+ T cells, PARP1 inhibition, 2OA-BSA murine immunization model, adoptive co-transfer, in vitro organoid co-culture cytotoxicity assay Journal of hepatology High 35753523
2023 4-octyl itaconate (4-OI) inhibits CD103+ TRM induction and effector functions by blocking DNA demethylation of RUNX3 in CD8+ T cells, thereby suppressing tissue-residency programming; 4-OI administration reduced intrahepatic CD103+ TRM and ameliorated liver injury in murine PSC models. In vitro 4-OI treatment of CD8+ T cells with RUNX3 methylation analysis, murine PSC models with 4-OI administration and IRG1-deficient mice, flow cytometry, immunofluorescence Hepatology Medium 37505225
2023 Retinoic acid signaling during T cell priming in mesenteric lymph nodes licenses intestinal CD103+ TRM cell differentiation in situ, independently of CCR9 expression/gut homing; T cells primed in the spleen are impaired in CD103+ TRM differentiation even after entering the intestine. Mesenteric lymph node vs. spleen priming comparison in mice, retinoic acid signaling blockade, CCR9 genetic studies, in vivo intestinal TRM differentiation assays The Journal of experimental medicine High 36809399
2024 CD103+ CD8+ TRM cells in primary Sjögren's disease salivary glands produce granzyme B and IFN-γ contributing to tissue damage; intraglandular blockade of CD103 with monoclonal antibody in an experimental SS mouse model reduced TRM accumulation, reduced glandular damage and improved salivary flow. Anti-CD103 monoclonal antibody intraglandular blockade in ESS mouse model, flow cytometry, scRNAseq of salivary gland T cells, immunostaining for granzyme B/IFN-γ Annals of the rheumatic diseases High 38777379

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. Nature immunology 1090 24162776
2016 Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition. Immunity 985 27096321
2016 Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma. Cancer cell 818 27424807
2018 Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors. Nature communications 730 30006565
2009 The origin and development of nonlymphoid tissue CD103+ DCs. The Journal of experimental medicine 604 20008528
2012 Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells. Immunity 572 22795876
2005 Essential role for CD103 in the T cell-mediated regulation of experimental colitis. The Journal of experimental medicine 392 16216886
2018 TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer. Cancer cell 323 29316433
2010 Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction. Gut 288 20427394
2020 Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells. Immunity 282 32610077
2011 CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen. The Journal of experimental medicine 253 21859845
2010 Development and functional specialization of CD103+ dendritic cells. Immunological reviews 215 20193025
2019 Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals. Science immunology 210 31278120
2019 CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: role of remote MiR-19b-3p. Molecular cancer 187 30975145
2014 Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow. Blood 181 25100743
2012 Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. Mucosal immunology 168 22643849
2014 CCR2(+)CD103(-) intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells. Mucosal immunology 135 25138666
2018 The Emerging Role of CD8+ Tissue Resident Memory T (TRM) Cells in Antitumor Immunity: A Unique Functional Contribution of the CD103 Integrin. Frontiers in immunology 130 30158938
2022 Blocking CD47 promotes antitumour immunity through CD103+ dendritic cell-NK cell axis in murine hepatocellular carcinoma model. Journal of hepatology 129 35367532
2000 T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines. Current opinion in cell biology 123 10978890
2009 Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells. The Journal of experimental medicine 120 19188499
2017 Interleukin-12 from CD103+ Batf3-Dependent Dendritic Cells Required for NK-Cell Suppression of Metastasis. Cancer immunology research 112 29070650
2019 Recruitment of CD103+ dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy. Science advances 111 31844672
2019 CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells. Nature immunology 108 31591568
2020 TRM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection. Proceedings of the National Academy of Sciences of the United States of America 107 32439709
2005 Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. Journal of immunology (Baltimore, Md. : 1950) 107 16034110
2019 FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation. Nature communications 103 30683885
2011 Mouse lung CD103+ and CD11bhigh dendritic cells preferentially induce distinct CD4+ T-cell responses. American journal of respiratory cell and molecular biology 92 21908266
2020 Vaccine efficacy against primary and metastatic cancer with in vitro-generated CD103+ conventional dendritic cells. Journal for immunotherapy of cancer 90 32273347
2017 TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine. Nature communications 89 28931816
2011 GM-CSF increases cross-presentation and CD103 expression by mouse CD8⁺ spleen dendritic cells. European journal of immunology 86 21660938
2015 CD103(+) Dendritic Cells Control Th17 Cell Function in the Lung. Cell reports 83 26365185
2009 Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer research 78 19638592
2023 CD103+ regulatory T cells underlie resistance to radio-immunotherapy and impair CD8+ T cell activation in glioblastoma. Nature cancer 72 37081259
2023 Tertiary Lymphoid Structure-Associated B Cells Enhance CXCL13+CD103+CD8+ Tissue-Resident Memory T-Cell Response to Programmed Cell Death Protein 1 Blockade in Cancer Immunotherapy. Gastroenterology 65 38445519
2020 T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development. Cell reports 65 32268106
2014 Smad and NFAT pathways cooperate to induce CD103 expression in human CD8 T lymphocytes. Journal of immunology (Baltimore, Md. : 1950) 65 24477908
2021 The Clinical Significance of Hepatic CD69+ CD103+ CD8+ Resident-Memory T Cells in Autoimmune Hepatitis. Hepatology (Baltimore, Md.) 60 33554350
2020 Mesenchymal stem cells alleviate rat diabetic nephropathy by suppressing CD103+ DCs-mediated CD8+ T cell responses. Journal of cellular and molecular medicine 59 32283569
2014 Osteopontin expression by CD103- dendritic cells drives intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America 58 24550510
2022 CD103 fate mapping reveals that intestinal CD103- tissue-resident memory T cells are the primary responders to secondary infection. Science immunology 55 36332012
2017 Mesenteric lymph node CD11b- CD103+ PD-L1High dendritic cells highly induce regulatory T cells. Immunology 55 28423181
2020 Characterization of CD103+ CD8+ tissue-resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti-PD-1 blockade. Cancer immunology, immunotherapy : CII 51 32285170
2020 KLRG1 and CD103 Expressions Define Distinct Intestinal Tissue-Resident Memory CD8 T Cell Subsets Modulated in Crohn's Disease. Frontiers in immunology 51 32477365
2006 Expression of CD103 identifies human regulatory T-cell subsets. The Journal of allergy and clinical immunology 51 17137867
2005 Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population. Journal of immunology (Baltimore, Md. : 1950) 51 16177076
2004 Regulation of CD103 expression by CD8+ T cells responding to renal allografts. Journal of immunology (Baltimore, Md. : 1950) 51 14688328
2019 Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma. Cancer research 49 30674537
2017 Microbiota-activated CD103+ DCs stemming from microbiota adaptation specifically drive γδT17 proliferation and activation. Microbiome 49 28438184
2023 Retinoic acid signaling during priming licenses intestinal CD103+ CD8 TRM cell differentiation. The Journal of experimental medicine 46 36809399
2022 NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis. Journal of hepatology 46 35753523
2017 Paxillin Binding to the Cytoplasmic Domain of CD103 Promotes Cell Adhesion and Effector Functions for CD8+ Resident Memory T Cells in Tumors. Cancer research 46 29021139
2013 Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses. PloS one 44 23691170
2021 TGF-β: Many Paths to CD103+ CD8 T Cell Residency. Cells 43 33922441
2019 Self-Maintaining CD103+ Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses. Cancer immunology research 42 31771983
2018 Aging impacts CD103+ CD8+ T cell presence and induction by dendritic cells in the genital tract. Aging cell 41 29455474
2018 Analysis of tumor-infiltrating CD103 resident memory T-cell content in recurrent laryngeal squamous cell carcinoma. Cancer immunology, immunotherapy : CII 41 30361882
2022 Cancer stem-like cells evade CD8+CD103+ tumor-resident memory T (TRM) lymphocytes by initiating an epithelial-to-mesenchymal transition program in a human lung tumor model. Journal for immunotherapy of cancer 38 35418483
2022 Secondary infections rejuvenate the intestinal CD103+ tissue-resident memory T cell pool. Science immunology 38 36332011
2020 CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function. Nature communications 38 33268774
2021 Systematic analysis of CD39, CD103, CD137, and PD-1 as biomarkers for naturally occurring tumor antigen-specific TILs. European journal of immunology 37 34505280
2021 γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release. Gastroenterology 37 34861219
2017 A Yin and Yang in Epithelial Immunology: The Roles of the αE(CD103)β7 Integrin in T Cells. The Journal of investigative dermatology 37 28941625
2015 Liver-resident CD103+ dendritic cells prime antiviral CD8+ T cells in situ. Journal of immunology (Baltimore, Md. : 1950) 36 25712214
2008 Alloantigen-induced regulatory CD8+CD103+ T cells. Human immunology 36 18822329
2021 Implication of CD69+ CD103+ tissue-resident-like CD8+ T cells as a potential immunotherapeutic target for cholangiocarcinoma. Liver international : official journal of the International Association for the Study of the Liver 35 33548061
2020 CD103+ tumor-resident CD8+ T cell numbers underlie improved patient survival in oropharyngeal squamous cell carcinoma. Journal for immunotherapy of cancer 35 32527931
2019 CD8+CD103+ iTregs Inhibit Chronic Graft-versus-Host Disease with Lupus Nephritis by the Increased Expression of CD39. Molecular therapy : the journal of the American Society of Gene Therapy 35 31402273
2015 Pulmonary CD103 expression regulates airway inflammation in asthma. American journal of physiology. Lung cellular and molecular physiology 35 25681437
2015 Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103- and XCR1+CD103+ dendritic cells. Oncoimmunology 35 26405572
2023 Intratumoral CD103+ CD8+ T cells predict response to neoadjuvant chemoimmunotherapy in advanced head and neck squamous cell carcinoma. Cancer communications (London, England) 34 37658605
2017 Toll-like receptor 3 in nasal CD103+ dendritic cells is involved in immunoglobulin A production. Mucosal immunology 34 28612840
2009 Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics. American journal of clinical pathology 34 19289595
2018 Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut. JCI insight 32 29515025
2012 Reduced frequencies and heightened CD103 expression among virus-induced CD8(+) T cells in the respiratory tract airways of vitamin A-deficient mice. Clinical and vaccine immunology : CVI 32 22398245
2022 CD103+CD8+ tissue-resident memory T cell infiltration predicts clinical outcome and adjuvant therapeutic benefit in muscle-invasive bladder cancer. British journal of cancer 31 35165401
2016 The transcription factor NR4A3 controls CD103+ dendritic cell migration. The Journal of clinical investigation 31 27820700
2021 Circulating CD103+ γδ and CD8+ T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease. Mucosal immunology 30 33654213
2018 Sex-based differences in CD103+ dendritic cells promote female-predominant Th2 cytokine production during allergic asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 29 29288569
2014 Intrinsically de-sialylated CD103(+) CD8 T cells mediate beneficial anti-glioma immune responses. Cancer immunology, immunotherapy : CII 27 24893855
2005 Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo. Journal of immunology (Baltimore, Md. : 1950) 27 16116203
2022 The tissue-resident marker CD103 on peripheral blood T cells predicts responses to anti-PD-1 therapy in gastric cancer. Cancer immunology, immunotherapy : CII 26 35776160
2021 Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal. Cellular and molecular gastroenterology and hepatology 25 33515805
2021 Integrin αE(CD103)β7 in Epithelial Cancer. Cancers 24 34944831
2019 Flt3 inhibition alleviates chronic kidney disease by suppressing CD103+ dendritic cell-mediated T cell activation. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 24 30590794
2023 CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden. Journal for immunotherapy of cancer 23 36792124
2020 Intratumoral CD103+CD4+ T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patients. Oncoimmunology 22 33312758
2022 TIGIT blockade enhances tumor response to radiotherapy via a CD103 + dendritic cell-dependent mechanism. Cancer immunology, immunotherapy : CII 21 35794399
2017 Diminished CD103 (αEβ7) Expression on Resident T Cells from the Female Genital Tract of HIV-Positive Women. Pathogens & immunity 21 28164171
2012 Diagnostic value of CD103 expression in bronchoalveolar lymphocytes in sarcoidosis. Respiratory medicine 21 22537923
2018 Reactive glia promote development of CD103+ CD69+ CD8+ T-cells through programmed cell death-ligand 1 (PD-L1). Immunity, inflammation and disease 20 29602245
2024 CD8+ tissue-resident memory T cells are expanded in primary Sjögren's disease and can be therapeutically targeted by CD103 blockade. Annals of the rheumatic diseases 19 38777379
2021 Distribution, phenotype, functional and clinical relevance of CD8+CD103+ tissue-resident memory T cells in human gastric cancer. Cancer immunology, immunotherapy : CII 19 34767045
2018 CD103+CD8+ T lymphocytes in non-small cell lung cancer are phenotypically and functionally primed to respond to PD-1 blockade. Cellular immunology 19 29448979
2023 PD-1 and TIGIT coexpressing CD8 + CD103 + tissue-resident memory cells in endometrial cancer as potential targets for immunotherapy. International immunopharmacology 18 38150880
2020 STAT3 Inhibits CD103+ cDC1 Vaccine Efficacy in Murine Breast Cancer. Cancers 18 31947933
2016 Batf3-dependent CD103(+) dendritic cell accumulation is dispensable for mucosal and systemic antifungal host defense. Virulence 18 27191829
2021 CD103 integrin identifies a high IL-10-producing FoxP3+ regulatory T-cell population suppressing allergic airway inflammation. Allergy 17 34658046
2016 Distinct recirculation potential of CD69+CD103- and CD103+ thymic memory CD8+ T cells. Immunology and cell biology 17 27328704
2023 Itaconate inhibits CD103 + T RM cells and alleviates hepatobiliary injury in mouse models of primary sclerosing cholangitis. Hepatology (Baltimore, Md.) 16 37505225