Affinage

ITGA9

Integrin alpha-9 · UniProt Q13797

Length
1035 aa
Mass
114.5 kDa
Annotated
2026-06-10
52 papers in source corpus 14 papers cited in narrative 14 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ITGA9 (integrin alpha-9) is a cell-surface adhesion receptor subunit that mediates cell-ECM and cell-cell interactions and transduces these into intracellular signaling that controls cell proliferation, migration, and tissue morphogenesis (PMID:21060781, PMID:41938137). Its canonical partner is the beta-1 integrin subunit, with which it participates in sperm-egg binding and fusion in mammalian gametes (PMID:19129508); in cells lacking beta-1, ITGA9 instead pairs with ITGB7 to form a functional ITGA9-ITGB7 heterodimer that binds the sperm protein ADAM2 (PMID:21060781). As a signaling receptor, ITGA9 drives the FAK-ERK1/2 axis to promote endothelial VEGFA expression and angiogenesis (PMID:41938137), serves as a receptor for the chemokine XCL1 in the spinal cord where XCL1-ITGA9 signaling is pronociceptive in neuropathic pain (PMID:36618360), and participates in a PIEZO1-ANGPT2-integrin alpha9beta1 mechanosensitive pathway in Schlemm's canal endothelium that regulates intraocular pressure, with its loss causing canal narrowing and glaucoma [PMID:bio_10.1101_2025.10.24.683742]. ITGA9 also negatively regulates endothelial proliferation and migration in a context-dependent manner (PMID:36573168) and delays cellular senescence downstream of METTL3-mediated m6A translational suppression (PMID:40153583). ITGA9 expression is tightly controlled: it is epigenetically silenced in breast cancer through CpG island methylation in its first intron (PMID:21975548) and post-transcriptionally repressed by multiple miRNAs including miR-148a and miR-194-5p, the latter acting in a CUL4B/miR-194-5p/ITGA9 axis that promotes macrophage migration and renal infiltration (PMID:31489579, PMID:37224018). A recurrent missense mutation in the ITGA9 beta-propeller domain has been linked to severe congenital chylothorax, implicating the gene in lymphatic development (PMID:18973153).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2008 Low

    Whether ITGA9 contributes to human developmental disease was unknown; identifying a recurrent coding mutation in chylothorax fetuses first linked ITGA9 to lymphatic development.

    Evidence candidate-gene sequencing and structural modeling in fetuses with congenital chylothorax

    PMID:18973153

    Open questions at the time
    • No functional rescue experiment performed
    • Inheritance pattern and mechanism of lymphatic defect not established
  2. 2009 Medium

    The receptors mediating gamete adhesion were incompletely defined; RNAi knockdown showed egg-surface ITGA9 contributes to sperm-egg binding and fusion.

    Evidence RNAi knockdown in mouse eggs with IVF binding/fusion assays and anti-ITGB1 antibody blockade

    PMID:19129508

    Open questions at the time
    • Partial (not complete) loss of fusion leaves redundant receptors unidentified
    • Direct ligand on sperm not defined in this study
  3. 2009 Medium

    Whether ITGA9 coding sequences can drive oncogenic phenotypes was untested; an MLH1-ITGA9 fusion conferred loss of contact inhibition, showing a gain-of-function effect from ITGA9 sequences.

    Evidence cloning and doxycycline-inducible expression of the fusion in murine fibroblasts with mismatch repair and contact-inhibition assays

    PMID:19188145

    Open questions at the time
    • Contribution of ITGA9 portion versus loss of MLH1 repair not fully dissected
    • Relevance to native ITGA9 signaling unclear
  4. 2010 Medium

    ITGA9 was assumed to require beta-1; demonstration of an ITGA9-ITGB7 heterodimer binding ADAM2 established beta-subunit plasticity and a defined ligand.

    Evidence anti-integrin antibody inhibition and ITGB7 siRNA in ADAM2 adhesion assays in RPMI 8866 cells

    PMID:21060781

    Open questions at the time
    • Physiological contexts where ITGA9-ITGB7 forms in vivo not defined
    • Single cell line
  5. 2011 Medium

    The basis of ITGA9 loss in cancer was unknown; pharmacological demethylation reactivated ITGA9, identifying CpG island methylation as the silencing mechanism.

    Evidence 5-aza-dC and Trichostatin A treatment with methylation analysis and qRT-PCR in MCF7 cells

    PMID:21975548

    Open questions at the time
    • Functional consequence of reactivated ITGA9 not assessed here
    • Methylation status across tumor types not surveyed
  6. 2019 Medium

    Post-transcriptional control of ITGA9 was poorly defined; multiple miRNAs were shown to directly repress ITGA9 to limit malignant phenotypes, with rescue restoring them.

    Evidence dual-luciferase 3'UTR reporter, miRNA overexpression and ITGA9 restoration with invasion/xenograft assays (miR-125b, miR-148a)

    PMID:26596831 PMID:31489579

    Open questions at the time
    • Downstream effector pathways of ITGA9 in these tumors not mapped
    • Whether the same miRNAs operate in normal tissue unclear
  7. 2022 Medium

    An immune/neural ligand for ITGA9 was unknown; functional blockade established ITGA9 as a spinal XCL1 receptor driving neuropathic hypersensitivity.

    Evidence intrathecal anti-ITGA9 (YA4) neutralization with behavioral pain testing in a CCI mouse model

    PMID:36618360

    Open questions at the time
    • Downstream neuronal signaling from XCL1-ITGA9 not defined
    • Cell type expressing ITGA9 in spinal cord not pinpointed
  8. 2022 Low

    ITGA9's role in endothelial behavior was ambiguous; overexpression showed it suppresses endothelial proliferation and migration, with miR-146a-3p relieving this restraint.

    Evidence ITGA9 overexpression and miR-146a-3p mimics with proliferation/migration assays and signaling Western blots in HMEC-1

    PMID:36573168

    Open questions at the time
    • No direct mechanistic validation linking ITGA9 to the listed signaling markers
    • Apparent opposite (anti-migratory) role versus pro-angiogenic findings unresolved
  9. 2023 Medium

    How ITGA9 is regulated in disease-associated macrophages was unclear; a CUL4B/miR-194-5p/ITGA9 axis was shown to drive macrophage migration and renal infiltration.

    Evidence myeloid-specific CUL4B knockout in two diabetic kidney disease mouse models with in vitro migration/adhesion assays

    PMID:37224018

    Open questions at the time
    • Direct adhesion ligand engaged by ITGA9 in renal infiltration not identified
    • Downstream signaling in macrophages not mapped
  10. 2025 Medium

    Whether m6A controls ITGA9 and links it to aging was untested; MeRIP-seq and rescue experiments placed ITGA9 downstream of METTL3 as a senescence brake.

    Evidence MeRIP-seq, METTL3 knockdown/overexpression, ITGA9 loss/gain epistasis, and a METTL3 transgenic mouse with senescence assays

    PMID:40153583

    Open questions at the time
    • Reader protein mediating translational suppression not identified
    • Mechanism by which ITGA9 delays senescence not defined
  11. 2025 Medium

    Cell-type specificity of ITGA9 in human testis was unknown; ITGA9 was validated as a surface marker distinguishing peritubular myoid cells from Leydig cells.

    Evidence scRNA-seq reanalysis, immunofluorescence, and FACS isolation using ITGA9/NGFR with in vitro culture

    PMID:40450328

    Open questions at the time
    • Functional role of ITGA9 within PTMs not tested
    • Adhesive ligand in the testicular niche not defined
  12. 2025 Medium

    How mechanical flow regulates Schlemm's canal was incompletely understood; ITGA9 was placed in a PIEZO1-ANGPT2-integrin alpha9beta1 mechanosensitive pathway controlling IOP and glaucoma.

    Evidence endothelial-specific Itga9 conditional knockout mice with IOP/SC morphology readouts and in vitro PIEZO1 activation (preprint)

    PMID:bio_10.1101_2025.10.24.683742

    Open questions at the time
    • Preprint not yet peer-reviewed
    • Direct integrin alpha9beta1 ligand mediating proliferation not defined
  13. 2026 Medium

    The signaling output of ITGA9 in angiogenesis was undefined; knockdown identified ITGA9-FAK-ERK1/2 as the axis driving VEGFA and endothelial angiogenesis.

    Evidence ITGA9 knockdown in HUVECs with tube formation, FAK/ERK1/2 Western blots, VEGFA measurement, and a subcutaneous implantation model

    PMID:41938137

    Open questions at the time
    • ECM ligand triggering ITGA9-FAK signaling not isolated
    • Reconciliation with anti-proliferative endothelial role unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • The native ECM ligands engaged by ITGA9-beta1 across its diverse tissue contexts, and how a single receptor reconciles pro- versus anti-proliferative/migratory outputs, remain unresolved.
  • No unifying structural/ligand model across endothelial, immune, and reproductive contexts
  • m6A reader and downstream senescence effectors unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 3 GO:0098631 cell adhesion mediator activity 2 GO:0001618 virus receptor activity 1
Localization
GO:0005886 plasma membrane 3
Pathway
R-HSA-162582 Signal Transduction 2 R-HSA-168256 Immune System 2 R-HSA-1474244 Extracellular matrix organization 1 R-HSA-8953854 Metabolism of RNA 1
Partners
ADAM2ANGPT2ITGB1ITGB7XCL1
Complex memberships
integrin alpha9-beta7integrin alpha9beta1

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2009 ITGA9 protein on mouse and human eggs participates in sperm-egg binding and fusion. RNA interference-mediated knockdown of Itga9 in mouse eggs reduced surface ITGA9 protein and resulted in reduced (but not complete loss of) sperm-egg binding and fusion in IVF assays at specific sperm:egg ratios, demonstrating ITGA9 and its likely beta partner ITGB1 are involved in gamete interactions. RNAi knockdown of Itga9 in mouse eggs, surface protein detection, IVF binding/fusion assays, function-blocking anti-ITGB1 antibody Biology of reproduction Medium 19129508
2010 ITGA9 forms a heterodimer with ITGB1 as its canonical beta partner, but in RPMI 8866 cells lacking detectable ITGB1, ITGA9 pairs with ITGB7 to form a novel ITGA9-ITGB7 integrin that functions as a binding partner for ADAM2. Anti-ITGA9 antibody and siRNA against ITGB7 both inhibited RPMI 8866 cell adhesion to ADAM2. Anti-integrin antibody inhibition, siRNA knockdown, cell adhesion assays to ADAM2, integrin subunit expression analysis PloS one Medium 21060781
2008 A recurrent heterozygous missense mutation in the beta-propeller domain of ITGA9 (c.1210G>A, p.G404S) was identified in human fetuses with severe congenital chylothorax who failed to respond to OK-432 pleurodesis treatment, suggesting ITGA9 function in lymphatic development. Computer modeling supported the deleterious nature of this substitution. Family analysis indicated autosomal recessive inheritance. Genotyping of candidate genes, Sanger sequencing, computer structural modeling, family analysis Prenatal diagnosis Low 18973153
2009 An interstitial deletion at 3p21.3 creates an in-frame fusion of MLH1 (exons 1-11) with ITGA9 (exons 17-28). The resulting MLH1*ITGA9 fusion protein lacks DNA mismatch repair capability, as shown by mismatch repair assays. Murine fibroblasts expressing the fusion gene exhibit loss-of-contact inhibition, demonstrating a gain-of-function oncogenic effect from the ITGA9 coding sequences. PCR, gene cloning, transfection studies, Western blot, mismatch repair functional assays, doxycycline-inducible expression in murine fibroblasts Clinical cancer research Medium 19188145
2015 miR-125b directly targets ITGA9 mRNA to suppress its expression, and ITGA9 upregulation in response to decreased miR-125b promotes melanoma cell migration and invasion. Restoration of miR-125b repressed ITGA9 expression and inhibited malignant phenotypes both in vitro and in vivo, while ITGA9 restoration reversed these effects. miRNA overexpression, ITGA9 knockdown and overexpression, in vitro invasion/migration assays, in vivo xenograft, luciferase reporter (implied by targeting), Western blot Tumour biology Low 26596831
2019 miR-148a directly targets ITGA9 as confirmed by dual-luciferase reporter gene assay. Overexpression of miR-148a decreased proliferation, migration, and invasiveness of glioblastoma cells and inhibited xenograft tumor growth; restoration of ITGA9 reversed these effects, placing ITGA9 downstream of miR-148a in glioblastoma progression. Dual-luciferase reporter assay, miRNA overexpression, ITGA9 knockdown and restoration, cell viability/migration/invasion assays, xenograft Human cell Medium 31489579
2023 CUL4B in macrophages represses expression of miR-194-5p, which leads to elevated ITGA9, promoting macrophage migration and adhesion, and renal infiltration in diabetic kidney disease. Loss of CUL4B in myeloid cells suppressed macrophage migration, adhesion, and renal infiltration via the CUL4B/miR-194-5p/ITGA9 axis, as demonstrated in two mouse DKD models. Myeloid-specific CUL4B knockout mouse models, in vitro migration and adhesion assays, miR-194-5p/ITGA9 expression analyses, in vivo/in vitro mechanistic studies Cell reports Medium 37224018
2022 ITGA9 functions as a receptor for the chemokine XCL1 in the spinal cord. Intrathecal neutralization of ITGA9 (using YA4 antibody) reversed XCL1-induced hypersensitivity in naive mice and reduced thermal and mechanical hypersensitivity after nerve injury. Neutralization of ITGA9 enhanced morphine and buprenorphine analgesia, demonstrating that XCL1-ITGA9 signaling is pronociceptive in neuropathic pain. Intrathecal injection of neutralizing antibodies (YA4 anti-ITGA9), von Frey and cold plate behavioral tests, RT-qPCR, Western blot, ELISA, immunofluorescence in CCI mouse model Frontiers in immunology Medium 36618360
2011 ITGA9 expression is epigenetically silenced in breast cancer via CpG island methylation in the first intron of the gene. Treatment with the demethylating agent 5-aza-dC restored ITGA9 expression in ITGA9-negative MCF7 cells; combined treatment with 5-aza-dC and Trichostatin A doubled ITGA9 reactivation, while TSA alone had no effect, identifying CpG methylation as the primary epigenetic mechanism of ITGA9 silencing. 5-aza-dC and Trichostatin A pharmacological treatment, qRT-PCR, methylation analysis of CpG island Cell adhesion & migration Medium 21975548
2022 Overexpression of ITGA9 in human microvascular endothelial cells (HMEC-1) inhibited cell proliferation and migration, while increasing expression of cdc42, ki67, FAK, Src, RAC1, and RhoA. miR-146a-3p targeted ITGA9 to lower its expression, resulting in increased HMEC-1 proliferation and migration, establishing ITGA9 as a negative regulator of endothelial cell proliferation and migration in psoriasis. ITGA9 overexpression, miR-146a-3p mimic transfection, CCK-8, EdU proliferation, annexin V apoptosis, wound healing, transwell assay, Western blot Clinical, cosmetic and investigational dermatology Low 36573168
2025 METTL3-mediated m6A modification negatively regulates ITGA9 expression through translational suppression. High-throughput MeRIP sequencing identified ITGA9 as a critical downstream m6A target. Loss-of-function and gain-of-function experiments showed that ITGA9 delays cellular senescence, and ITGA9 inhibition reversed the anti-senescence effect of METTL3 silencing, while ITGA9 overexpression counteracted METTL3-driven senescence acceleration. MeRIP sequencing, METTL3 knockdown/overexpression, ITGA9 loss/gain-of-function, METTL3 transgenic mouse model, β-galactosidase assay, p16 expression, cell proliferation assays Aging and disease Medium 40153583
2026 ITGA9 mediates pro-angiogenic signaling via the FAK-ERK1/2 pathway in endothelial cells. A decellularized extracellular matrix/GelMA composite hydrogel upregulated ITGA9 expression in HUVECs, activating FAK-ERK1/2 and enhancing VEGFA expression and angiogenesis. Knockdown of ITGA9 abolished these pro-angiogenic effects, confirming ITGA9-FAK-ERK1/2 as the operative signaling axis. ITGA9 knockdown, HUVEC viability/migration/tube formation assays, Western blot for FAK/ERK1/2, VEGFA measurement, mouse subcutaneous implantation model Materials today. Bio Medium 41938137
2025 ITGA9 in Schlemm's canal (SC) endothelium participates in a mechanosensitive ANGPT2-integrin α9β1 signaling pathway regulating intraocular pressure (IOP). PIEZO1 activation triggers ANGPT2 secretion and promotes cell-surface clustering of integrin α9β1. Deletion of SC-expressed Itga9 in mice caused SC narrowing, impaired flow-mediated SC endothelial proliferation, IOP elevation, and glaucoma. Endothelial-specific Itga9 conditional knockout mice, IOP measurement, SC morphology analysis, in vitro PIEZO1 activation assays, ANGPT2 blockade bioRxivpreprint Medium bio_10.1101_2025.10.24.683742
2025 ITGA9 expression identifies human testicular peritubular myoid cells (PTMs): ITGA9+/NGFR+ cells are positive for PTM markers (SMA, CNN1) and negative for Leydig cell markers (HSD3B, STAR), and can form tubular and spheroid structures in vitro. ITGA9−/NGFR+ cells represent adult Leydig cells. This establishes ITGA9 as a cell-surface marker enabling FACS-based isolation of PTMs from human testes. Single-cell RNA-seq reanalysis, immunofluorescence staining, FACS isolation using ITGA9/NGFR surface markers, in vitro culture and functional characterization Reproductive biology and endocrinology Medium 40450328

Source papers

Stage 0 corpus · 52 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1987 Cloning and characterization of mammalian myosin regulatory light chain (RLC) cDNA: the RLC gene is expressed in smooth, sarcomeric, and nonmuscle tissues. The Journal of cell biology 80 3584239
2013 Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in disease. The Journal of biological chemistry 72 23530050
2009 A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma. Journal of human genetics 67 19478819
2006 Prolonged Ca2+ and force transients in myosin RLC transgenic mouse fibers expressing malignant and benign FHC mutations. Journal of molecular biology 54 16837010
2005 The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice. Journal of cell science 52 16076902
2008 A recurrent ITGA9 missense mutation in human fetuses with severe chylothorax: possible correlation with poor response to fetal therapy. Prenatal diagnosis 47 18973153
2012 The effect of myosin RLC phosphorylation in normal and cardiomyopathic mouse hearts. Journal of cellular and molecular medicine 44 21696541
1974 Regulation of phosphoenolpyruvate carboxykinase and tyrosine transaminase in hepatoma cell cultures. 3. Comparative studies in H35, HTC, MH1C1 and RLC cells. The Journal of cell biology 42 4148931
1985 Phosphorylation of regulatory light chain a (RLC-a) in smooth muscle myosin of scallop, Patinopecten yessoensis. Journal of biochemistry 41 3840802
2011 Integrin alpha9 (ITGA9) expression and epigenetic silencing in human breast tumors. Cell adhesion & migration 39 21975548
1979 Comparative studies of glucose metabolism in HTC, RLC, MH1C1, and Reuber H35 rat hepatoma cells. Cancer research 37 427745
2015 MicroRNA-125b suppresses the epithelial-mesenchymal transition and cell invasion by targeting ITGA9 in melanoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 29 26596831
2019 MiR-148a inhibits the proliferation and migration of glioblastoma by targeting ITGA9. Human cell 28 31489579
2009 Reduction of mouse egg surface integrin alpha9 subunit (ITGA9) reduces the egg's ability to support sperm-egg binding and fusion. Biology of reproduction 27 19129508
1988 A cAMP-dependent regulatory protein for RLC-a myosin kinase catalyzing the phosphorylation of scallop smooth muscle myosin light chain. Journal of biochemistry 27 2839466
2008 [Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer]. Molekuliarnaia biologiia 25 19140316
1986 Purification of a protein kinase phosphorylating myosin regulatory light chain-a (RLC-a) from smooth muscle of scallop, Patinopecten yessoensis. Journal of biochemistry 25 3102465
2021 Long Non-Coding RNA HOXA11-AS Modulates Proliferation, Apoptosis, Metastasis and EMT in Cutaneous Melanoma Cells Partly via miR-152-3p/ITGA9 Axis. Cancer management and research 24 33564267
2014 Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells. Nucleic acids research 24 24561616
2023 Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis. Cell reports 23 37224018
2010 ADAM2 interactions with mouse eggs and cell lines expressing α4/α9 (ITGA4/ITGA9) integrins: implications for integrin-based adhesion and fertilization. PloS one 23 21060781
2022 New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions - evidence from animal studies. Frontiers in immunology 19 36618360
2019 Therapeutic potential of AAV9-S15D-RLC gene delivery in humanized MYL2 mouse model of HCM. Journal of molecular medicine (Berlin, Germany) 19 31101927
1975 The effects of a glucocorticoid on the cell surface of RLC-GAI cells. Journal of cellular physiology 18 1202032
2020 Long Noncoding RNA CCAT1 Functions as a Competing Endogenous RNA to Upregulate ITGA9 by Sponging MiR-296-3p in Melanoma. Cancer management and research 15 32606961
2020 Traumatic brain injury in mice induces changes in the expression of the XCL1/XCR1 and XCL1/ITGA9 axes. Pharmacological reports : PR 15 33185818
2009 An interstitial deletion at 3p21.3 results in the genetic fusion of MLH1 and ITGA9 in a Lynch syndrome family. Clinical cancer research : an official journal of the American Association for Cancer Research 15 19188145
1999 Dynamic modulation of the regulatory domain of myosin heads by pH, ionic strength, and RLC phosphorylation in synthetic myosin filaments. Biochemistry 15 10074367
2022 ITGA9: Potential Biomarkers and Therapeutic Targets in Different Tumors. Current pharmaceutical design 13 35490433
2014 Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on β-myosin cross-bridge mechanics. Journal of applied physiology (Bethesda, Md. : 1985) 12 25324513
2006 E22K mutation of RLC that causes familial hypertrophic cardiomyopathy in heterozygous mouse myocardium: effect on cross-bridge kinetics. American journal of physiology. Heart and circulatory physiology 12 16751284
2023 RLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice. The Journal of general physiology 8 36715675
2016 A post-MI power struggle: adaptations in cardiac power occur at the sarcomere level alongside MyBP-C and RLC phosphorylation. American journal of physiology. Heart and circulatory physiology 7 27233767
2022 ITGA9 Inhibits Proliferation and Migration of Dermal Microvascular Endothelial Cells in Psoriasis. Clinical, cosmetic and investigational dermatology 6 36573168
1991 Recombinant DNA approaches to study the role of the regulatory light chains (RLC) using scallop myosin as a test system. Journal of cell science. Supplement 6 1885660
2024 Polymorphisms of ITGA9 Gene and Their Correlation with Milk Quality Traits in Yak (Bos grunniens). Foods (Basel, Switzerland) 4 38890842
2017 Cardiac contractility, motor function, and cross-bridge kinetics in N47K-RLC mutant mice. The FEBS journal 4 28467684
2002 Possible involvement of phospholipase C and protein kinase C in stimulatory actions of L-leucine and its keto acid, alpha-ketoisocaproic acid, on protein synthesis in RLC-16 hepatocytes. Cytotechnology 3 19003115
2025 The Flip Side of the Coin: METTL3 Serves as a Novel Cellular Senescence Accelerator via Negative Regulation of ITGA9. Aging and disease 2 40153583
2025 Identification and isolation of human testicular peritubular myoid cells and Leydig cells by a combination of ITGA9 and NGFR. Reproductive biology and endocrinology : RB&E 2 40450328
2023 ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and recruiting HNRNPU to affect the proliferation and apoptosis of non-small cell lung cancer cells. Cellular and molecular biology (Noisy-le-Grand, France) 2 38279497
2021 RLC score (R status, lymphovascular invasion, C-reactive protein) predicts survival following radical cystectomy for muscle-invasive bladder cancer. Aktuelle Urologie 2 33445183
2020 Carbon tetrachloride suppresses ER-Golgi transport by inhibiting COPII vesicle formation on the ER membrane in the RLC-16 hepatocyte cell line. Cell biology international 2 33247607
2019 Clinical relationships between the rs2212020 and rs189897 polymorphisms of the ITGA9 gene and epithelial ovarian cancer. Journal of genetics 2 30945681
1999 Expression of chicken gizzard RLC complements the cytokinesis and developmental defects of Dictyostelium RLC null cells. Journal of muscle research and cell motility 2 10412089
1975 [The importance of the substrate for the induction of tyrosine-alpha-ketoglutarate-transaminase in RLC-cells (author's transl)]. Zeitschrift fur Naturforschung. Section C, Biosciences 2 240238
2021 PHY, MAC, and RLC Layer Based Estimation of Optimal Cyclic Prefix Length. Sensors (Basel, Switzerland) 1 34300536
2011 [Association of ITGA9 gene rs189897 and rs2212020 genotypes and its haplotype with cerebral infarction]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 1 21764681
2026 Hepatic cavernous hemangioma decellularized extracellular matrix/GelMA composite hydrogel promotes angiogenesis via the ITGA9-FAK-ERK1/2 axis. Materials today. Bio 0 41938137
2026 RCLARITY: A Prospective Phase II Study of Rituximab Combined With Lenalidomide and Chidamide (RLC) for the Treatment of Relapsed/Refractory Angioimmunoblastic T-Cell Lymphoma. American journal of hematology 0 42124356
2021 Association study of hypertension susceptibility genes ITGA9, MOV10, and CACNB2 with preeclampsia in Chinese Han population. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 0 33491517
2021 Long Noncoding RNA CCAT1 Functions as a Competing Endogenous RNA to Upregulate ITGA9 by Sponging MiR-296-3p in Melanoma [Retraction]. Cancer management and research 0 34916849

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