Affinage

INHBB

Inhibin beta B chain · UniProt P09529

Round 2 corrected
Length
407 aa
Mass
45.1 kDa
Annotated
2026-04-28
46 papers in source corpus 16 papers cited in narrative 16 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

INHBB encodes the inhibin βB subunit, which homodimerizes to form activin B or heterodimerizes with βA to form activin AB; these TGF-β superfamily ligands signal through type II activin receptors (ActRIIA/ActRIIB) and type I receptors ALK4/ALK7 to activate Smad2/3, or, in hepatic contexts, ALK3 to activate Smad1/5/8 (PMID:2575216, PMID:15196700, PMID:22611157). Activin B circulates as an endocrine factor and acts as a potent regulator of FSH secretion, skeletal muscle mass (via ActRIIB/atrogene induction), inflammation-induced hepcidin expression, and testis cell composition (PMID:18927237, PMID:24378873, PMID:22611157, PMID:35022746). In paracrine settings, INHBB-derived activin B produced by injured epithelial cells activates fibroblasts and stellate cells through Smad signaling to promote renal and hepatic fibrosis, and drives EMT and metastasis in colorectal and hepatocellular carcinoma models (PMID:34543458, PMID:33246092, PMID:41380489). Transcription of INHBB is positively regulated by Sox9 via direct enhancer binding and repressed by Menin through Akt/Ezh2-mediated H3K27me3 deposition (PMID:33246092, PMID:28215965).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1986 High

    Identification of INHBB as a distinct inhibin β subunit gene established that inhibin exists in two forms (βA and βB) sharing a common alpha chain, laying the molecular foundation for understanding activin/inhibin diversity.

    Evidence cDNA cloning and sequencing of the human βB subunit from ovarian cDNA libraries

    PMID:3754442

    Open questions at the time
    • No functional assay for the βB subunit alone
    • Dimerization partners and receptor not yet identified
  2. 1989 High

    Reconstitution of activin B from cloned INHBB cDNA demonstrated that the βB subunit homodimerizes to form a bioactive ligand indistinguishable from activin A in stimulating FSH release and erythroid differentiation, establishing activin B as a functional TGF-β superfamily member.

    Evidence Transfection/secretion in mammalian cells, pituitary FSH bioassay, K562 hemoglobin induction assay

    PMID:2575216

    Open questions at the time
    • Receptor identity unknown
    • In vivo relevance not tested
  3. 1991 High

    Demonstration that activin B binds a cloned transmembrane serine/threonine kinase receptor with subnanomolar affinity and competes with activin A resolved how both activin isoforms converge on a shared receptor system.

    Evidence Radioligand binding and competition assay in COS cells expressing cloned activin receptor

    PMID:1646080

    Open questions at the time
    • Type I receptor specificity not defined
    • Intracellular signaling cascade downstream of binding unknown
  4. 2000 High

    A knock-in replacing Inhba coding sequence with Inhbb showed that activin B can rescue activin A-dependent craniofacial development but cannot fully substitute in testicular, genital, and hair phenotypes, establishing both overlapping and distinct biological activities for the two activin isoforms in vivo.

    Evidence Gene targeting knock-in in mice, systematic phenotypic analysis

    PMID:10932194

    Open questions at the time
    • Molecular basis of differential bioactivity not resolved
    • Whether differences reflect receptor affinity or tissue availability unclear
  5. 2004 High

    Identification of ALK7 as a preferential type I receptor for activin B (versus ALK4 for activin A) and demonstration that activin B stimulates insulin secretion through ALK7/ActRIIA provided a mechanistic basis for isoform-specific signaling.

    Evidence Receptor binding assays, reporter gene assays, and insulin secretion assays in MIN6 pancreatic β-cells

    PMID:15196700

    Open questions at the time
    • Structural basis for ALK7 selectivity not determined
    • In vivo relevance of ALK7-mediated insulin secretion not confirmed
  6. 2008 High

    Affinity-purification of activin B from native human and mouse serum confirmed its status as a circulating endocrine factor and revealed that it, like myostatin, inhibits myoblast differentiation, expanding its role beyond reproductive endocrinology to muscle biology.

    Evidence Soluble ActRII/ActRIIB affinity purification from serum, mass spectrometry, myoblast differentiation assay

    PMID:18927237

    Open questions at the time
    • In vivo muscle mass effects not yet demonstrated
    • Relative contribution versus myostatin unknown
  7. 2012 High

    Activin B was shown to induce hepcidin via Smad1/5/8 phosphorylation through ALK3 in hepatocytes, synergizing with IL-6/STAT3, establishing a non-canonical BMP-like signaling mode for activin B in inflammatory iron regulation.

    Evidence LPS challenge in mice, Smad1/5/8 phosphorylation assays, ALK3 inhibitor studies, primary hepatocyte assays

    PMID:22611157

    Open questions at the time
    • Whether ALK3 engagement is direct or requires co-receptors not resolved
    • Contribution relative to BMP6 in hepcidin induction in vivo unclear
  8. 2013 High

    In vivo overexpression of activin B in muscle demonstrated that it is a potent inducer of atrophy through ActRIIB-mediated upregulation of atrogenes and suppression of Akt/mTOR protein synthesis, confirming a direct catabolic role in skeletal muscle.

    Evidence rAAV6-mediated overexpression in mouse muscle, ubiquitin ligase and Akt/mTOR pathway analysis

    PMID:24378873

    Open questions at the time
    • Endogenous activin B contribution to cachexia not proven by loss-of-function
    • Relative potency versus activin A in muscle wasting not quantified
  9. 2017 Medium

    Epigenetic regulation of INHBB transcription was resolved: Menin recruits Ezh2 via Akt-dependent phosphorylation to deposit H3K27me3 repressive marks at the Inhbb locus, and Menin loss de-represses activin B in insulinoma, linking tumor suppressor pathways to activin B expression.

    Evidence ChIP for H3K27me3 and Ezh2, Menin-knockout cell lines, Akt inhibitor experiments, in vivo insulinoma models

    PMID:28215965

    Open questions at the time
    • Whether Menin-Ezh2 regulation of INHBB operates outside pancreatic neuroendocrine tissue not established
    • Direct versus indirect Akt-Ezh2 link not fully dissected
  10. 2020 Medium

    Sox9 was identified as a direct transcriptional activator of INHBB via enhancer binding, and secreted activin B was shown to activate hepatic stellate cells through Smad signaling to promote fibrosis and metastasis, establishing a Sox9-INHBB-Smad paracrine axis in the liver tumor microenvironment.

    Evidence ChIP for Sox9 at INHBB enhancer, orthotopic HCC model, Smad signaling inhibition

    PMID:33246092

    Open questions at the time
    • Whether Sox9 regulation of INHBB is tissue-general or liver-specific not determined
    • Identity of specific Smad pathway (Smad2/3 vs Smad1/5/8) in stellate cell activation not resolved
  11. 2021 Medium

    Extension of the paracrine fibrosis paradigm to kidney showed that tubular epithelial INHBB activates interstitial fibroblasts through activin B/Smad signaling, with INHBB inhibition ameliorating renal fibrosis, generalizing the injured-epithelium-to-fibroblast paracrine mechanism.

    Evidence In vivo INHBB overexpression and inhibition in UUO and ischemia-reperfusion injury mouse models, Smad signaling assays

    PMID:34543458

    Open questions at the time
    • Specific Smad isoform usage in renal fibroblasts not determined
    • Whether follistatin or other endogenous antagonists modulate this axis in vivo not tested
  12. 2022 Medium

    A missense INHBB variant that selectively disrupts activin B (but not inhibin B) biosynthesis increased Sertoli and spermatid cell numbers in knock-in mice without affecting fertility, disentangling activin B from inhibin B function and demonstrating a specific role for activin B in testis cell composition.

    Evidence CRISPR/Cas9 knock-in mice, in vitro biosynthesis assay, serum hormone analysis, histomorphometry

    PMID:35022746

    Open questions at the time
    • Mechanism by which reduced activin B increases Sertoli cell number not identified
    • Whether this variant affects activin AB heterodimerization not tested
  13. 2023 Medium

    INHBB was linked to endometrial decidualization through an ADCY1/cAMP axis, where INHBB knockdown suppressed cAMP production and downstream decidualization markers, connecting activin B to non-Smad signaling in reproductive biology.

    Evidence siRNA knockdown in human endometrial stromal cells, RNA-seq, cAMP analogue rescue

    PMID:36913138

    Open questions at the time
    • Whether activin B directly upregulates ADCY1 transcription or acts indirectly not resolved
    • Receptor and Smad-independence of this pathway not formally tested
  14. 2025 Medium

    INHBB was shown to promote colorectal cancer metastasis by sustaining Smad2/3/Smad4 phosphorylation, EMT, and anoikis resistance, extending the pro-metastatic role of activin B signaling beyond HCC to additional gastrointestinal cancers.

    Evidence siRNA knockdown in CRC cell lines, Smad phosphorylation and EMT marker analysis, splenic injection xenograft hepatic metastasis model

    PMID:41380489

    Open questions at the time
    • Whether the effect is autocrine or paracrine in the metastatic niche not distinguished
    • Activin B-specific versus pan-activin contribution not dissected

Open questions

Synthesis pass · forward-looking unresolved questions
  • The structural basis for activin B's selective engagement of ALK7 versus ALK4, the relative in vivo contribution of activin B versus other ActRIIB ligands (myostatin, GDF11) in muscle wasting, and the mechanism linking activin B to ADCY1/cAMP signaling independently of canonical Smad pathways remain unresolved.
  • No crystal structure of activin B in complex with ALK7
  • No conditional Inhbb knockout dissecting endogenous activin B roles across tissues
  • Smad-independent signaling mechanisms of activin B poorly characterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 6 GO:0098772 molecular function regulator activity 2
Localization
GO:0005576 extracellular region 5
Pathway
R-HSA-162582 Signal Transduction 7 R-HSA-1643685 Disease 3 R-HSA-1266738 Developmental Biology 2 R-HSA-1474165 Reproduction 2 GO:0048018 receptor ligand activity 1
Partners
ACVR1BACVR1CACVR2AACVR2BINHAINHBAMEN1SOX9
Complex memberships
Activin AB heterodimer (βA-βB)Activin B homodimer (βB-βB)Inhibin B heterodimer (α-βB)

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1989 The INHBB gene encodes a 407-amino acid precursor with a prepro region of 292 amino acids followed by the mature 115-amino acid C-terminal domain. Mammalian cells transfected with a βB-subunit expression plasmid secreted an activin B homodimer (~22 kDa). Co-expression of βA and βB subunits produced all three activin isoforms (A, AB, and B). Purified activin B stimulated FSH release in vitro and induced hemoglobin accumulation in K562 cells with potency (ED50 ~2 ng/ml) indistinguishable from activin A. cDNA/genomic cloning, transfection and secretion assay, in vitro pituitary FSH assay, K562 cell differentiation assay Molecular endocrinology High 2575216
1986 Human ovarian inhibin consists of two forms sharing a common alpha subunit covalently linked to one of two distinct beta subunits (βA or βB). The βB subunit sequence (INHBB) is highly conserved with its porcine equivalent, differing at only one of 232 positions. cDNA cloning and nucleotide sequencing Biochemical and biophysical research communications High 3754442
1991 Activin B (the INHBB homodimer) binds to the cloned activin receptor (a predicted transmembrane serine/threonine kinase) expressed in COS cells with an affinity of 180 pM, and can compete with activin A for receptor binding. Expression cloning, 125I-activin A binding competition assay in COS cell transfectants Cell High 1646080
2000 Replacement of the mature protein-coding region of Inhba with Inhbb (creating the InhbaBK knock-in allele) rescued Inhba-null craniofacial phenotypes (whisker, palate, tooth defects), demonstrating functional compensation between activin A and activin B within the TGF-β superfamily when expressed from the same locus. However, novel somatic, testicular, genital, and hair growth phenotypes emerged, indicating distinct dosage and bioactivity differences between the two ligands. Gene targeting (knock-in), mouse genetics, phenotypic analysis Nature genetics High 10932194
2000 Activin βC subunit (encoded by a related gene) can form heterodimers with activin βA and βB subunits in vitro (activin AC and BC), but cannot dimerize with the inhibin alpha subunit. This establishes that INHBB (βB) is capable of forming novel heterodimeric activin complexes beyond the canonical activin B homodimer. In vitro dimerization assay, antibody localization, co-immunoprecipitation The Journal of clinical endocrinology and metabolism Medium 11134153
2004 Activin B (INHBB homodimer) and activin AB signal through the type I receptor serine/threonine kinase ALK7, in combination with ActRIIA, to mediate insulin secretion from pancreatic β-cells. This receptor preference distinguishes activin B from activin A (which preferentially uses ALK4). The differential signaling depends on the homo- or heterodimeric assembly of activin isoforms. Receptor binding assay, reporter gene assay, pancreatic β-cell (MIN6) insulin secretion assay, receptor co-expression experiments Molecular and cellular endocrinology High 15196700
2008 Activin B (INHBB homodimer) was identified in human and mouse serum by affinity purification using soluble ActRII and ActRIIB, confirming it circulates as an endocrine factor. Activin B bound both ActRII and ActRIIB and, like myostatin, inhibited myoblast-to-myotube differentiation in vitro. Affinity purification from serum, mass spectrometry proteomics, in vitro binding assay, myoblast differentiation assay Molecular endocrinology High 18927237
2012 Activin B (encoded by Inhbb) induces phosphorylation of Smad1/5/8 in human hepatoma-derived cells and, synergistically with IL-6/STAT-3 signaling, up-regulates hepcidin expression. The effect on hepcidin is mediated through BMP signaling, most likely via activin receptor-like kinase 3 (ALK3). Inhbb mRNA is dramatically induced in mouse liver after LPS challenge, preceding Smad1/5/8 phosphorylation and hepcidin (Hamp) mRNA increases. In vivo LPS challenge, Smad1/5/8 phosphorylation assay, qPCR, ALK3 inhibitor treatment, primary hepatocyte assay Blood High 22611157
2013 Elevated activin B (among other activins) reduces skeletal muscle mass and function by stimulating the ActRIIB pathway, leading to increased transcription of atrophy-related ubiquitin ligases and decreased Akt/mTOR-mediated protein synthesis. Activin B was identified as one of the most potent negative regulators of muscle mass, and the resulting muscle wasting is fully reversible. rAAV6-mediated overexpression in mice, ActRIIB signaling assays, ubiquitin ligase expression assays, Akt/mTOR pathway analysis FASEB journal High 24378873
2015 RNAi-mediated knockdown of INHBB in mouse granulosa cells arrests cells in G1 phase, increases apoptosis, and decreases estradiol and progesterone production. Mechanistically, INHBB knockdown downregulated Cyclin D1, Cyclin E, and Bcl2 protein expression while upregulating Bax, and reduced mRNA levels of CYP19A1 and CYP11A1, placing INHBB as a regulator of cell cycle progression and steroidogenesis in granulosa cells. RNAi knockdown, flow cytometry, Western blot, ELISA, qRT-PCR The Journal of reproduction and development Medium 26063610
2017 Menin represses Inhbb expression by facilitating recruitment of Ezh2 to the Inhbb promoter via an indirect mechanism involving Akt phosphorylation, resulting in H3K27me3 repressive marks at the Inhbb locus. Loss of Menin leads to reduced H3K27me3 at the Inhbb locus and increased activin B expression both in vitro and in vivo in insulinoma models. ChIP assay, H3K27me3 chromatin immunoprecipitation, Menin knockout cell lines and animal models, Akt inhibitor experiments Biochimica et biophysica acta. Gene regulatory mechanisms Medium 28215965
2020 Sox9 directly binds to the INHBB enhancer and induces INHBB expression in hepatoma cells, promoting secretion of activin B. Secreted activin B in turn activates surrounding hepatic stellate cells through activin B/Smad signaling, promoting liver fibrosis and HCC metastasis. Inhibition of activin B/Smad signaling attenuated peri-tumoral fibrosis and metastasis. Gain- and loss-of-function experiments, ChIP assay (Sox9 binding to INHBB enhancer), orthotopic HCC tumor model, Smad signaling inhibition Cancer letters Medium 33246092
2021 Tubular epithelial cell-derived INHBB (activin B) promotes renal fibrosis by activating surrounding interstitial fibroblasts in a paracrine manner through activin B/Smad signaling. Ectopic expression of INHBB in tubular cells initiates interstitial fibrosis in vivo, while INHBB inhibition blocks fibroblast activation and ameliorates fibrosis from ureteral obstruction or ischemia-reperfusion injury. Upregulation of INHBB in injured tubular cells depends on transcription factor Sox9. In vivo INHBB inhibition and ectopic overexpression in mouse fibrosis models, in vitro overexpression in tubular cells, Smad signaling assays The Journal of pathology Medium 34543458
2022 A missense variant in INHBB (p.Met360Thr/p.Met364Thr in mice) disrupts activin B biosynthesis in vitro without affecting inhibin B production, reducing circulating activin B levels. In knock-in mice, this variant increased testis size, Sertoli cell number, and round spermatid number without affecting fertility, demonstrating that activin B specifically regulates testis cell composition independent of FSH. CRISPR/Cas9 knock-in mouse model, in vitro biosynthesis assay, serum hormone analysis, histomorphometry Endocrinology Medium 35022746
2023 INHBB knockdown in human endometrial stromal cells suppresses ADCY1-mediated cAMP production and downstream cAMP signaling, thereby attenuating decidualization. RNA-seq identified INHBB-ADCY1 as a mechanistic axis, and a positive correlation between INHBB and ADCY1 expression was confirmed in endometria from recurrent implantation failure patients. siRNA knockdown, RNA-seq, cAMP analogue rescue experiment, qRT-PCR, Pearson correlation analysis Journal of assisted reproduction and genetics Medium 36913138
2025 INHBB knockdown in colorectal cancer cells reduces migration, invasion, and hepatic metastasis in vivo by attenuating TGF-β/Smad2/3/Smad4 signaling (decreased Smad2/3 phosphorylation), reversing EMT (E-cadherin upregulation, N-cadherin and vimentin downregulation), and sensitizing cells to anoikis. siRNA knockdown in HCT116/Caco-2 cells, Western blot for Smad phosphorylation, EMT markers and anoikis assay, in vivo spleen injection xenograft model Tissue & cell Medium 41380489

Source papers

Stage 0 corpus · 46 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
1991 Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 710 1646080
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature genetics 657 23263486
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2002 Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. Molecular & cellular proteomics : MCP 621 12543931
2003 Serum anti-Müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3. Human reproduction (Oxford, England) 465 12571168
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
1986 Structure of two human ovarian inhibins. Biochemical and biophysical research communications 324 3754442
2008 Anti-mullerian hormone and inhibin B in the definition of ovarian aging and the menopause transition. The Journal of clinical endocrinology and metabolism 260 18593767
2007 Symptoms associated with menopausal transition and reproductive hormones in midlife women. Obstetrics and gynecology 235 17666595
2011 Toward an understanding of the protein interaction network of the human liver. Molecular systems biology 207 21988832
2016 Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. European urology 169 27423503
2013 Elevated expression of activins promotes muscle wasting and cachexia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 164 24378873
2000 Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nature genetics 162 10932194
2012 Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood 141 22611157
2011 A genome-wide association study on obesity and obesity-related traits. PloS one 135 21552555
1989 Activin B: precursor sequences, genomic structure and in vitro activities. Molecular endocrinology (Baltimore, Md.) 125 2575216
2004 Activin isoforms signal through type I receptor serine/threonine kinase ALK7. Molecular and cellular endocrinology 121 15196700
2008 Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators. Molecular endocrinology (Baltimore, Md.) 116 18927237
2013 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. PloS one 107 23326517
2010 A large-scale candidate gene association study of age at menarche and age at natural menopause. Human genetics 106 20734064
2000 Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit. The Journal of clinical endocrinology and metabolism 92 11134153
2010 Family-based analysis of candidate genes for polycystic ovary syndrome. The Journal of clinical endocrinology and metabolism 91 20200332
1997 Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells. Endocrinology 89 9202237
2012 Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene. PloS one 86 22432041
1989 Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice. Genomics 85 2767687
2009 Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin beta subunits, and anti-Müllerian hormone in human granulosa cells. Fertility and sterility 83 19539911
1988 Inhibin: definition and nomenclature, including related substances. Endocrinology 81 3345731
1999 A novel role of activin in inflammation and repair. The Journal of endocrinology 80 10320815
1989 Characterization and regulation of testicular inhibin beta-subunit mRNA. Molecular endocrinology (Baltimore, Md.) 70 2739657
2015 RNAi-mediated knockdown of INHBB increases apoptosis and inhibits steroidogenesis in mouse granulosa cells. The Journal of reproduction and development 43 26063610
2020 Sox9/INHBB axis-mediated crosstalk between the hepatoma and hepatic stellate cells promotes the metastasis of hepatocellular carcinoma. Cancer letters 39 33246092
2021 Tubule-derived INHBB promotes interstitial fibroblast activation and renal fibrosis. The Journal of pathology 25 34543458
2017 Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification. Biochimica et biophysica acta. Gene regulatory mechanisms 16 28215965
2020 KLF10 is upregulated in osteoarthritis and inhibits chondrocyte proliferation and migration by upregulating Acvr1 and suppressing inhbb expression. Acta histochemica 13 32156482
2024 Circular RNA circRPS19 promotes chicken granulosa cell proliferation and steroid hormone synthesis by interrupting the miR-218-5p/INHBB axis. Theriogenology 7 38422566
2022 Human INHBB Gene Variant (c.1079T>C:p.Met360Thr) Alters Testis Germ Cell Content, but Does Not Impact Fertility in Mice. Endocrinology 7 35022746
2024 Inhibin subunit beta B (INHBB): an emerging role in tumor progression. Journal of physiology and biochemistry 6 39183219
2021 Effect of Mouse Ovarian Vitrification on Promoter Methylation of Inhba and Inhbb in Granulosa Cells of Follicles. Cryo letters 5 33970982
2023 Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway. Journal of assisted reproduction and genetics 4 36913138
2023 INHBB promotes tumor aggressiveness and stemness of glioblastoma via activating EGFR signaling. Pathology, research and practice 4 37116368
2000 Linkage mapping of the ovine alpha-inhibin (INHA) beta(A)-inhibin/activin (INHBA) and beta(B)-inhibin/activin (INHBB) genes. The Journal of heredity 4 10912684
1990 BamHI RFLP of the inhibin beta B (INHBB) chain gene on chromosome 2. Nucleic acids research 2 1979678
2021 Identification of Novel Nucleotide Changes in INHBB Gene by Mutation Screening in Females with Ovarian Dysgenesis: A Case Report. Journal of reproduction & infertility 1 34987992
2025 INHBB promotes liver metastasis of colorectal cancer via regulation of TGF-β/Smad signaling, EMT and anoikis resistance. Tissue & cell 0 41380489