Affinage

IL17RB

Interleukin-17 receptor B · UniProt Q9NRM6

Length
502 aa
Mass
55.9 kDa
Annotated
2026-06-10
100 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IL17RB is a transmembrane cytokine receptor subunit that serves as the primary high-affinity binding chain for IL-25 (IL-17E) and IL-17B, signaling through a heteromeric complex with IL-17RA to drive type 2 immune responses (PMID:11058597, PMID:18768888, PMID:30770417). Ligand engagement activates NF-κB with downstream induction of proinflammatory chemokines (PMID:11058597), and the IL-25/IL-17RB axis requires both IL-17RB and IL-17RA to elicit IL-5/IL-13 production, pulmonary inflammation, and airway hyperresponsiveness in vivo (PMID:18768888). IL-17RB marks and functions on diverse effector populations—IL-25-responsive iNKT cells, IL-4-producing myeloid cells, and basophils whose survival and IgE-mediated degranulation it enhances—thereby orchestrating Th2-type immunity (PMID:19342692, PMID:19828636, PMID:20545698); its expression is itself dynamically controlled, being upregulated by IL-3 and suppressed by COX-2-derived prostaglandins through a PKA-dependent mechanism (PMID:20545698, PMID:23449692). Beyond immunity, IL-17RB activates distinct downstream effectors in a context-specific manner: PI3K signaling to induce bFGF-driven angiogenesis (PMID:23106660), ERK1/2 signaling to upregulate MMP-9 and promote cancer cell invasion (PMID:28715683), and NF-κB activation supporting HTLV-1 Tax-induced T-cell immortalization through a feed-forward loop with IL-9 as a downstream proliferative target (PMID:25340344). In epithelial cancers, IL-17RB is upregulated by Treg-derived TGF-β1 via Smad2/3/4 in breast cancer and marks tuft-cell-like cancer stem cells whose ablation suppresses tumor growth (PMID:28993429, PMID:31182574). A non-immune neuromodulatory role has also been defined, in which neuronal IL-17E acting on IL-17RB-expressing cortical neurons promotes social interaction (PMID:40199322).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2000 Medium

    Establishing the molecular identity of the receptor was the first step: cloning EVI27/IL-17RB defined a novel IL-17-receptor-family transmembrane protein with multiple isoforms and a proviral-integration link to surface overexpression.

    Evidence cDNA cloning, Northern/Western blot, chromosomal mapping, and retroviral integration site analysis

    PMID:10815801

    Open questions at the time
    • No ligand identified at this stage
    • Functional consequences of soluble isoforms not resolved
    • Signaling output unknown
  2. 2001 High

    Identifying IL-25 (IL-17E) as the ligand and demonstrating NF-κB activation and IL-8 induction assigned the receptor a concrete signaling function.

    Evidence Ligand-receptor binding assay with NF-κB and IL-8 production readouts

    PMID:11058597

    Open questions at the time
    • Co-receptor requirement not yet defined
    • In vivo physiological role untested
    • Proximal signaling adaptors not mapped
  3. 2008 High

    Genetic dissection showed IL-25 requires both IL-17RB and IL-17RA, establishing that signaling occurs through a heteromeric receptor complex driving Th2 cytokines and airway inflammation in vivo.

    Evidence IL-17RB and IL-17RA knockout mice, blocking antibodies, and intranasal IL-25 challenge

    PMID:18768888

    Open questions at the time
    • Stoichiometry and structural basis of the complex not resolved
    • Cell type executing the in vivo response not pinned down
  4. 2009 High

    Defining the responder cells, IL-17RB was shown to mark IL-25-responsive iNKT cells and IL-4-producing myeloid cells, linking receptor expression to specific Th2 effector outputs.

    Evidence Flow cytometry, cell sorting, adoptive transfer into iNKT-deficient mice, and 4get reporter mice with anti-SCF neutralization

    PMID:19342692 PMID:19828636

    Open questions at the time
    • Transcriptional control of cell-type-restricted IL-17RB expression unclear
    • Relative contribution of each cell type in disease not quantified
  5. 2010 Medium

    Demonstrating that IL-25/IL-17RB inhibits basophil apoptosis and enhances degranulation, and that IL-3 upregulates the receptor, connected the receptor to effector-cell survival and allergic effector function.

    Evidence Primary human basophil assays: qRT-PCR, beta-hexosaminidase release, and Annexin-V apoptosis

    PMID:20545698

    Open questions at the time
    • Anti-apoptotic signaling mechanism not delineated
    • Human-to-mouse generalizability untested
  6. 2012 Medium

    Showing IL-25 induces endothelial bFGF and angiogenesis specifically through IL-17RB (not IL-17RA) via PI3K revealed receptor-subunit-specific, non-Th2 signaling outputs.

    Evidence Receptor-blocking antibodies, PI3K inhibitor, siRNA, and in vitro angiogenesis assay

    PMID:23106660

    Open questions at the time
    • How IL-17RB signals independently of IL-17RA mechanistically unclear
    • In vivo angiogenic relevance not established
  7. 2013 Medium

    Identifying COX-2/prostaglandin-PKA suppression of IL-17RB expression established negative regulatory control of the receptor that restrains Th9 differentiation.

    Evidence COX-2 knockout mice, COX-2 inhibitor, synthetic prostaglandins, PKA inhibitor, and siRNA

    PMID:23449692

    Open questions at the time
    • Transcription factors mediating PKA-dependent repression not identified
    • Generalizability beyond lung inflammation untested
  8. 2014 Medium

    Two studies extended IL-17RB into disease pathways: HTLV-1 Tax induces IL-17RB via IKK/NF-κB to support T-cell immortalization through an IL-9-driven loop, and IL-17RB shapes the Th2/Th17 balance and inflammation during RSV infection.

    Evidence RNA-seq, loss-of-function and NF-κB reporter assays, T-cell immortalization assays, and IL-17RB knockout mice with RSV challenge

    PMID:24407884 PMID:25340344

    Open questions at the time
    • Direct biochemical link between IL-17RB and IKK not resolved
    • Ligand dependence of the HTLV-1 loop unclear
  9. 2017 Medium

    Cancer studies defined upstream control and downstream effectors: Treg-derived TGF-β1 upregulates IL-17RB via Smad2/3/4 in breast cancer, and IL-17B/IL-17RB activates ERK1/2-MMP-9 to drive thyroid cancer invasion, plus a role in hepatic progenitor growth.

    Evidence Syngeneic tumor models with TGF-β1 neutralization and Treg depletion, siRNA with invasion/metastasis assays and ERK1/2 inhibition, and liver regeneration models with extracellular vesicles

    PMID:27925343 PMID:28715683 PMID:28993429

    Open questions at the time
    • Whether IL-17B vs IL-25 drives each effect not always disentangled
    • Hepatic progenitor mechanism is correlative (Low confidence)
  10. 2019 Medium

    IL-17RB was shown to mark functional tuft-cell-like cancer stem cells whose ablation suppresses tumor growth, and IL-17B was confirmed to signal through an IL-17RA/IL-17RB heterocomplex on primary human type 2 lymphocytes.

    Evidence Il17rb lineage-tracing mice, CRISPR knockin organoids, in vivo CSC ablation, and receptor-blocking antibodies on primary human lymphocytes

    PMID:30770417 PMID:31182574

    Open questions at the time
    • Signaling driving CSC maintenance downstream of IL-17RB not mapped
    • POU2F3-IL17RB regulatory relationship not mechanistically resolved
  11. 2025 Medium

    Discovery of cortical neuronal IL-17RB driving social behavior in response to neuron-derived IL-17E revealed a wholly non-immune, neuromodulatory function of the receptor.

    Evidence Brain-wide receptor expression mapping, conditional loss-of-function, and social interaction behavioral assays

    PMID:40199322

    Open questions at the time
    • Neuronal signaling pathway downstream of IL-17RB unknown
    • Whether IL-17RA is the obligate co-receptor in neurons not fully resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • The proximal signaling machinery (adaptors, structural basis of the IL-17RA/IL-17RB heterocomplex) and the rules governing IL-25- versus IL-17B-specific and IL-17RA-independent outputs remain unresolved.
  • No structural model of the ligand-bound heteroreceptor
  • Adaptor proteins linking IL-17RB to NF-κB/ERK/PI3K not identified in the corpus
  • Determinants of subunit-specific signaling unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 3 GO:0048018 receptor ligand activity 1
Localization
GO:0005886 plasma membrane 2
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 3
Partners
IL17BIL17RAIL25
Complex memberships
IL-17RA/IL-17RB heteromeric receptor

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 IL-17E (IL-25) is a ligand for IL-17RB (EVI27/IL-17Rh1); binding of IL-17E to IL-17RB induces activation of NF-κB and stimulates production of the proinflammatory chemokine IL-8. Ligand-receptor binding assay, NF-κB activation assay, IL-8 production assay The Journal of biological chemistry High 11058597
2000 IL-17RB (EVI27) encodes a novel transmembrane protein with homology to the IL-17 receptor; it is expressed as multiple isoforms including putative secreted soluble forms generated by intron incorporation or proteolytic cleavage; proviral integration at the Evi27 locus increases surface expression of the protein. Northern blot, Western blot, cDNA cloning, chromosomal mapping, retroviral integration site analysis Oncogene Medium 10815801
2008 IL-25-mediated biological activities (IL-5 and IL-13 production, pulmonary inflammation, airway hyperresponsiveness) require both IL-17RB and IL-17RA, demonstrating that IL-25 signals through a heteromeric receptor complex composed of IL-17RB and IL-17RA. Knockout mice (IL-17RB KO and IL-17RA KO), antagonistic monoclonal antibodies, in vitro splenocyte stimulation, in vivo intranasal IL-25 administration Journal of immunology High 18768888
2009 IL-17RB is highly expressed on a subset of invariant NKT (iNKT) cells but not on activated conventional T cells; IL-17RB+ iNKT cells produce large amounts of Th2 cytokines upon IL-25 stimulation and are sufficient to restore airway hyperreactivity (AHR) in iNKT-deficient mice, whereas IL-17RB− iNKT cells cannot. Flow cytometry, cell sorting, adoptive transfer reconstitution experiments in iNKT-deficient mice, intranasal IL-25 challenge Journal of immunology High 19342692
2009 IL-17RB is expressed on IL-4-producing CD11b+GR1+ myeloid cells in lung and bone marrow during chronic allergen challenge; SCF-dependent signaling from c-kit+ eosinophils drives IL-25 production, which then acts on IL-17RB+ myeloid cells to stimulate Th2 cytokine production. Cell sorting, 4get reporter mice (IL-4-IRES-eGFP), anti-SCF neutralization, flow cytometry Journal of immunology Medium 19828636
2010 IL-3 upregulates both mRNA and protein expression of IL-17RB on basophils; IL-25 acting through IL-17RB inhibits apoptosis of basophils and enhances IgE-mediated degranulation. Flow cytometry, quantitative RT-PCR, beta-hexosaminidase release assay, Annexin-V apoptosis assay, allergen challenge of PBMCs Clinical and experimental allergy Medium 20545698
2012 IL-25 (IL-17E) promotes bFGF expression by human endothelial cells through IL-17RB but not IL-17RA; this IL-17RB-mediated bFGF production involves PI3K signaling and drives angiogenesis; blocking IL-17RB (not IL-17RA) abrogates IL-25-induced angiogenesis. Receptor-blocking antibodies, PCR, ELISA, in vitro angiogenesis assay, PI3K inhibitor (LY294002), siRNA knockdown Clinical and experimental allergy Medium 23106660
2013 COX-2-derived prostaglandins PGD2 and PGE2 suppress IL-17RB expression in T cells via a protein kinase A-dependent mechanism, thereby inhibiting Th9 cell differentiation during allergic lung inflammation. COX-2 knockout mice, COX-2 inhibitor treatment, synthetic prostaglandins, siRNA knockdown, flow cytometry, real-time PCR, immunoblotting, PKA inhibitor American journal of respiratory and critical care medicine Medium 23449692
2014 IL-17RB is aberrantly overexpressed in HTLV-1 immortalized T cells; HTLV-1 Tax induces IL-17RB expression via IKK/NF-κB-dependent mechanism; IL-17RB expression is required for Tax-induced canonical NF-κB activation, HTLV-1-induced immortalization of primary T cells, and survival of HTLV-1 transformed cells; IL-9 is an important downstream target gene of the IL-17RB pathway driving proliferation. RNA sequencing, knockdown/knockout experiments, NF-κB reporter assays, T-cell immortalization assays, IKK inhibitors, cytokine measurements PLoS pathogens Medium 25340344
2014 IL-17E (IL-25) and IL-17RB are increased following RSV infection; IL-17RB knockout mice show decreased Th2 and increased Th17 cytokine production during RSV infection and significantly reduced inflammation in a model of RSV-driven asthma exacerbation. IL-17RB knockout mice, antibody neutralization, cytokine measurements, airway hyperresponsiveness assays Journal of leukocyte biology Medium 24407884
2017 TGF-β1 secreted from regulatory T cells (Tregs) in tumor-draining lymph nodes upregulates IL-17RB in breast cancer cells via downstream Smad2/3/4 signaling, and elevated IL-17RB contributes to increased malignancy and distant metastasis. Syngeneic mouse mammary tumor model, lymph node removal, TGF-β1 neutralization, Treg depletion, Smad2/3/4 signaling analysis, xenograft assay EMBO molecular medicine Medium 28993429
2017 IL-17B acting through IL-17RB activates ERK1/2 signaling and increases MMP-9 expression in thyroid cancer cells, thereby promoting invasion and metastasis; ERK1/2 pathway inhibition blocks IL-17RB-mediated invasion and MMP-9 upregulation. siRNA knockdown of IL-17RB, in vitro invasion/migration assays, in vivo metastasis experiments, western blot for ERK1/2 phosphorylation and MMP-9, ERK1/2 inhibitor Molecular immunology Medium 28715683
2016 Co-delivery of IL17RB siRNA with doxorubicin in breast cancer cells causes significant silencing of NF-κB and Bcl-2 expression, induces apoptosis, and inhibits migration, consistent with IL17RB/IL17B signaling promoting cell growth and migration through NF-κB and Bcl-2 upregulation. siRNA knockdown, nanoparticle co-delivery, Annexin-V apoptosis assay, wound healing assay, qRT-PCR for NF-κB and Bcl-2 Biomedicine & pharmacotherapy Low 27372407
2019 IL-17RB marks intestinal tumor stem cells (TSCs) in mouse intestinal adenomas in an IL-13-dependent manner; in human colorectal cancers, IL17RB-expressing cancer stem cells expand independently of IL-13 with upregulation of POU2F3, a master regulator of tuft cell differentiation; long-term ablation of IL17RB-expressing CSCs strongly suppresses tumor growth in vivo. Il17rb-CreERT2-IRES-EGFP lineage tracing mice, CRISPR-Cas9 knockin organoids, xenograft tumors, in vivo CSC ablation Proceedings of the National Academy of Sciences of the United States of America Medium 31182574
2019 IL-17B signals through a heteromeric receptor complex composed of IL-17RA and IL-17RB to induce type 2 cytokine secretion from human innate type 2 lymphocytes, NKT cells, and CD4+ CRTH2+ Th2 cells; IL-17B can augment IL-33-driven type 2 responses. Primary human lymphocyte stimulation, receptor-blocking antibodies against IL-17RA and IL-17RB, cytokine ELISA Journal of immunology Medium 30770417
2017 IL-17RB expression on Thy1+ cell-derived extracellular vesicle-stimulated small hepatocyte-like progenitor cells (SHPCs) is upregulated by IL17B (from sinusoidal endothelial cells) and IL25 (from Kupffer cells); IL-17B stimulation of IL-17RB promotes growth of hepatocytic progenitor cells and enhances liver regeneration. GeneChip analysis, extracellular vesicle isolation and administration, in vitro small hepatocyte culture with IL-17B stimulation, in vivo liver regeneration model (retrorsine/partial hepatectomy) Stem cells Low 27925343
2025 IL-17RB is expressed in cortical neurons in the brain; IL-17E expressed in cortical neurons enhances social interaction by acting on IL-17RA- and IL-17RB-expressing neurons; IL-17RB (but not IL-17RC) plays a role in social behaviors through its cortical expression. Brain-wide receptor expression mapping, conditional loss-of-function, behavioral assays (social interaction) Cell Medium 40199322

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.). British journal of haematology 524 24328678
2016 Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase. Nature 481 26909574
2001 IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. The Journal of biological chemistry 313 11058597
2008 Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. Journal of immunology (Baltimore, Md. : 1950) 279 18768888
2010 Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell 273 20178741
2014 Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus. Cancer cell 205 25026211
2010 Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. Molecular cell 204 21035370
2011 Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase. Genes & development 195 21828267
2015 Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4. Blood cancer journal 189 26430725
2010 CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Molecular cell 188 20932472
2013 Prediction of late disease recurrence and extended adjuvant letrozole benefit by the HOXB13/IL17BR biomarker. Journal of the National Cancer Institute 169 23812955
2017 pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase. Nature communications 145 28530236
2021 CRL4AMBRA1 is a master regulator of D-type cyclins. Nature 140 33854235
2010 CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis. Molecular cell 140 20129063
2011 Control of Drosophila endocycles by E2F and CRL4(CDT2). Nature 130 22037307
2018 Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity. Blood 109 30042095
2013 CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science (New York, N.Y.) 103 24357321
2011 SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. The Journal of cell biology 101 21220508
2007 HOXB13-to-IL17BR expression ratio is related with tumor aggressiveness and response to tamoxifen of recurrent breast cancer: a retrospective study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 99 17308270
2019 Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15. Cell reports 93 31693891
2014 CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases. Molecular cell 89 25557551
2022 Targeting CRL4 suppresses chemoresistant ovarian cancer growth by inducing mitophagy. Signal transduction and targeted therapy 87 36481655
2009 Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. Journal of immunology (Baltimore, Md. : 1950) 85 19342692
2018 Vpr Targets TET2 for Degradation by CRL4VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication. Molecular cell 83 29883611
2020 ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells. Nature chemical biology 75 32958952
2013 Ubiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancer. The Journal of biological chemistry 75 23995842
2013 Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase. Molecular cell 70 23478441
2013 The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells. Nucleic acids research 69 23677613
2015 CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation. Nature communications 68 26281983
2009 Pulmonary IL-17E (IL-25) production and IL-17RB+ myeloid cell-derived Th2 cytokine production are dependent upon stem cell factor-induced responses during chronic allergic pulmonary disease. Journal of immunology (Baltimore, Md. : 1950) 67 19828636
2012 Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease. Frontiers in oncology 65 22649780
2020 PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network. Molecular cell 64 31973889
2016 Co-delivery of IL17RB siRNA and doxorubicin by chitosan-based nanoparticles for enhanced anticancer efficacy in breast cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 64 27372407
2016 Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma. EBioMedicine 61 27333051
2017 The role of IL17B-IL17RB signaling pathway in breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 59 28160754
2012 CRL4(CDT2) targets CHK1 for PCNA-independent destruction. Molecular and cellular biology 59 23109433
2017 Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1. Journal of medicinal chemistry 57 28358507
2010 Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 57 20545698
2019 Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America 54 31182574
2018 Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase. Nature communications 52 29691401
2013 A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase. The Journal of biological chemistry 50 23913683
2011 Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best! FEBS letters 50 21550341
2000 Evi27 encodes a novel membrane protein with homology to the IL17 receptor. Oncogene 50 10815801
2007 Exploring the two-gene ratio in breast cancer--independent roles for HOXB13 and IL17BR in prediction of clinical outcome. Breast cancer research and treatment 49 17453342
2017 TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB. EMBO molecular medicine 48 28993429
2014 Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death. Proceedings of the National Academy of Sciences of the United States of America 48 25349427
2019 The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation. Cellular and molecular life sciences : CMLS 44 31492966
2023 Glucose-induced CRL4COP1-p53 axis amplifies glycometabolism to drive tumorigenesis. Molecular cell 43 37390815
2021 USP15 antagonizes CRL4CRBN-mediated ubiquitylation of glutamine synthetase and neosubstrates. Proceedings of the National Academy of Sciences of the United States of America 43 34583995
2015 The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications. Oncotarget 43 26460955
2024 Transcription-coupled DNA-protein crosslink repair by CSB and CRL4CSA-mediated degradation. Nature cell biology 42 38600236
2020 CRL4DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development. Science advances 42 33355139
2012 CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10. Nucleic acids research 41 22570418
2013 VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases. BMC molecular biology 40 24028781
2019 Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability. EMBO reports 39 31267705
2018 CRL4DCAF2 negatively regulates IL-23 production in dendritic cells and limits the development of psoriasis. The Journal of experimental medicine 39 30018073
2018 Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase. The Journal of biological chemistry 39 30442713
2008 Association of IL-17RB gene polymorphism with asthma. Chest 39 19118269
2019 Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer. The Journal of pathology 37 30945288
2013 Cyclooxygenase-2 inhibits T helper cell type 9 differentiation during allergic lung inflammation via down-regulation of IL-17RB. American journal of respiratory and critical care medicine 37 23449692
2016 Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. Molecular cell 36 27203177
2014 IL-17E (IL-25) and IL-17RB promote respiratory syncytial virus-induced pulmonary disease. Journal of leukocyte biology 36 24407884
2016 CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nature communications 35 27098497
2011 The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1. Biochemistry 34 21226479
2014 A critical role for IL-17RB signaling in HTLV-1 tax-induced NF-κB activation and T-cell transformation. PLoS pathogens 33 25340344
2025 Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB. Cell 32 40199322
2020 The RepID-CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation. Nature communications 32 31911655
2020 CRL4Cdt2: Coupling Genome Stability to Ubiquitination. Trends in cell biology 32 32044173
2012 Interleukin-25 promotes basic fibroblast growth factor expression by human endothelial cells through interaction with IL-17RB, but not IL-17RA. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 32 23106660
2010 Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4(Cdt2) -mediated proteolysis. Genes to cells : devoted to molecular & cellular mechanisms 32 21143559
2017 CRL4DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver. Cell reports 31 28178526
2017 IL-17RB enhances thyroid cancer cell invasion and metastasis via ERK1/2 pathway-mediated MMP-9 expression. Molecular immunology 31 28715683
2013 HOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease. Breast cancer research : BCR 30 23497539
2023 Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex. Nature communications 29 37353483
2022 Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences of the United States of America 29 35105802
2021 IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion. Nature communications 28 33911083
2020 The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer. International journal of biological sciences 28 32140074
2020 CRL4DCAF8 dependent opposing stability control over the chromatin remodeler LSH orchestrates epigenetic dynamics in ferroptosis. Cell death and differentiation 28 33288900
2018 CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory. PLoS genetics 27 29370161
2019 Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes. Journal of immunology (Baltimore, Md. : 1950) 26 30770417
2016 CRL4(WDR23)-Mediated SLBP Ubiquitylation Ensures Histone Supply during DNA Replication. Molecular cell 26 27203182
2017 Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly. Journal of virology 25 28202763
2011 The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex. BMC pulmonary medicine 25 21473777
2022 CRL4CRBN E3 Ligase Complex as a Therapeutic Target in Multiple Myeloma. Cancers 24 36139651
2015 CRL4(RBBP7) is required for efficient CENP-A deposition at centromeres. Journal of cell science 24 25795299
2014 CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing. Proceedings of the National Academy of Sciences of the United States of America 24 24449894
2022 Hypoxia-inducible CircPFKFB4 Promotes Breast Cancer Progression by Facilitating the CRL4DDB2 E3 Ubiquitin Ligase-mediated p27 Degradation. International journal of biological sciences 23 35813480
2019 Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism. Current biology : CB 23 31155351
2017 HIV-1 Vpr protein directly loads helicase-like transcription factor (HLTF) onto the CRL4-DCAF1 E3 ubiquitin ligase. The Journal of biological chemistry 23 29079575
2021 CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation. International journal of molecular sciences 21 34065512
2020 Inflammation and DNA Methylation-Dependent Down-Regulation of miR-34b-5p Mediates c-MYC Expression and CRL4DCAF4 E3 Ligase Activity in Colitis-Associated Cancer. The American journal of pathology 21 31972160
2011 Upregulation of IL17RB during natural allergen exposure in patients with seasonal allergic rhinitis. Allergology international : official journal of the Japanese Society of Allergology 21 21252617
2018 CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. The EMBO journal 20 30166453
2017 Transplantation of Thy1+ Cells Accelerates Liver Regeneration by Enhancing the Growth of Small Hepatocyte-Like Progenitor Cells via IL17RB Signaling. Stem cells (Dayton, Ohio) 20 27925343
2014 C/EBPα regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint. Cell cycle (Georgetown, Tex.) 20 25483090
2023 Recognition of the CCT5 di-Glu degron by CRL4DCAF12 is dependent on TRiC assembly. The EMBO journal 19 36715408
2023 A Degron Blocking Strategy Towards Improved CRL4CRBN Recruiting PROTAC Selectivity. Chembiochem : a European journal of chemical biology 19 37418539
2019 Characteristic Pattern of IL-17RA, IL-17RB, and IL-17RC in Monocytes/Macrophages and Mast Cells From Patients With Bullous Pemphigoid. Frontiers in immunology 19 31572359
2017 SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. The FEBS journal 19 28886238
2013 Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2. Cell cycle (Georgetown, Tex.) 18 23892434

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