Affinage

IL17RB

Interleukin-17 receptor B · UniProt Q9NRM6

Length
502 aa
Mass
55.9 kDa
Annotated
2026-04-28
100 papers in source corpus 17 papers cited in narrative 17 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IL-17RB is a type I transmembrane cytokine receptor that partners with IL-17RA to form the heteromeric signaling complex for IL-17E (IL-25) and IL-17B, transducing signals that drive type 2 immune responses, NF-κB activation, and downstream Th2 cytokine production (PMID:11058597, PMID:18768888, PMID:30770417). IL-17RB is selectively expressed on innate immune effectors including invariant NKT cells, basophils, and IL-4-producing myeloid cells, where IL-25 engagement promotes Th2 cytokine secretion, inhibits apoptosis, and enhances IgE-mediated degranulation (PMID:19342692, PMID:20545698, PMID:19828636). Beyond immunity, IL-17RB marks intestinal and colorectal cancer stem cells whose ablation suppresses tumor growth, and IL-17B/IL-17RB signaling in cancer cells activates ERK1/2- and NF-κB-dependent programs promoting invasion, survival, and metastasis (PMID:31182574, PMID:28715683, PMID:28993429). In the brain, IL-17RB cooperates with IL-17RA on cortical neurons to mediate IL-17E-dependent enhancement of social behavior (PMID:40199322).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2000 Medium

    Molecular cloning revealed that IL-17RB (EVI27) encodes a novel IL-17 receptor-family transmembrane protein with multiple isoforms including secreted soluble forms, establishing it as a candidate cytokine receptor expressed on immune cell lineages.

    Evidence Molecular cloning, Northern blot, and Western blot in T-cell, B-cell, and myeloid cell lines

    PMID:10815801

    Open questions at the time
    • No ligand identified at this stage
    • Functional signaling consequence unknown
    • Single-lab characterization
  2. 2001 High

    The ligand for IL-17RB was identified as IL-17E (IL-25), and receptor engagement was shown to activate NF-κB and induce IL-8, establishing IL-17RB as a functional signaling receptor.

    Evidence Ligand-receptor binding assay, NF-κB reporter assay, and IL-8 ELISA

    PMID:11058597

    Open questions at the time
    • Co-receptor requirements unknown
    • Downstream signaling intermediates not mapped
    • In vivo relevance not tested
  3. 2008 High

    Genetic and antibody-blocking experiments demonstrated that IL-25 signaling requires a heteromeric IL-17RB/IL-17RA complex, resolving the receptor architecture and explaining why neither subunit alone suffices for biological activity.

    Evidence IL-17RB−/− and IL-17RA−/− mice, antagonistic monoclonal antibodies, splenocyte cytokine assays, and intranasal IL-25 pulmonary inflammation model

    PMID:18768888

    Open questions at the time
    • Stoichiometry and structural basis of the heteromeric complex unresolved
    • Whether IL-17B also requires IL-17RA was not tested
  4. 2009 High

    Cell-type-specific expression studies revealed that IL-17RB marks a subset of CD4+ iNKT cells and IL-4-producing myeloid cells, identifying the key innate immune effector populations that drive IL-25-dependent Th2 responses and airway hyperreactivity.

    Evidence Flow cytometry, adoptive transfer into iNKT-deficient mice with AHR readout; cell sorting and 4get reporter mice with anti-SCF neutralization

    PMID:19342692 PMID:19828636

    Open questions at the time
    • Molecular basis for selective IL-17RB expression on these subsets unknown
    • Transcriptional regulation of IL-17RB in iNKT cells not defined
  5. 2010 Medium

    IL-17RB was shown to be expressed on basophils and upregulated by IL-3; IL-25 engagement inhibited basophil apoptosis and enhanced IgE-mediated degranulation, extending the receptor's functional scope to granulocyte biology.

    Evidence Flow cytometry, qRT-PCR, Annexin-V apoptosis assay, and β-hexosaminidase degranulation assay on basophils

    PMID:20545698

    Open questions at the time
    • Signaling intermediates downstream of IL-17RB in basophils not mapped
    • Single-lab finding
    • In vivo basophil-specific role not tested
  6. 2012 Medium

    In endothelial cells, IL-25 was found to signal through IL-17RB (but not IL-17RA) via a PI3K-dependent pathway to induce bFGF and angiogenesis, revealing a context where IL-17RB may signal independently of IL-17RA.

    Evidence Receptor-blocking antibodies, siRNA, PI3K inhibitor LY294002, in vitro angiogenesis assay

    PMID:23106660

    Open questions at the time
    • Apparent IL-17RA-independence conflicts with KO data; residual IL-17RA expression not excluded
    • Single lab, in vitro only
    • PI3K engagement mechanism not defined
  7. 2013 Medium

    Prostaglandins PGD2 and PGE2 were shown to suppress Th9 differentiation by downregulating IL-17RB expression via protein kinase A, revealing transcriptional regulation of the receptor as a control point for T-helper subset balance.

    Evidence COX-2 KO mice, synthetic prostaglandins, PKA inhibitors, siRNA, flow cytometry

    PMID:23449692

    Open questions at the time
    • Direct PKA target elements in the IL17RB promoter not identified
    • Whether this applies to other IL-17RB-expressing cell types unknown
  8. 2014 High

    IL-17RB was implicated in viral oncogenesis: HTLV-1 Tax induces IL-17RB via NF-κB, and IL-17RB is required for Tax-driven NF-κB activation and T-cell immortalization through an IL-9-dependent autocrine loop, placing IL-17RB in a positive feedback circuit in adult T-cell leukemia.

    Evidence RNA-seq, siRNA knockdown, NF-κB reporter, T-cell immortalization assay, ATL patient sample analysis

    PMID:25340344

    Open questions at the time
    • Mechanism by which IL-17RB feeds back to activate NF-κB is unclear
    • Whether IL-17RB is targetable therapeutically in ATL not tested
  9. 2014 Medium

    IL-17RB knockout mice showed reduced Th2-driven immunopathology during RSV infection with a reciprocal increase in Th17 responses, demonstrating that IL-17RB tips the Th2/Th17 balance during respiratory viral infection.

    Evidence IL-17RB−/− mice, RSV infection and asthma exacerbation model, cytokine measurement, AHR assay

    PMID:24407884

    Open questions at the time
    • Whether the Th17 shift is a direct consequence of lost IL-17RB signaling or secondary compensation is unresolved
    • Single lab
  10. 2017 Medium

    Multiple studies demonstrated cancer-promoting roles: TGF-β1/Smad signaling upregulates IL-17RB in breast tumors to promote metastasis, and IL-17B/IL-17RB activates ERK1/2-MMP-9 in thyroid cancer to drive invasion, establishing IL-17RB as a signaling hub for tumor progression across cancer types.

    Evidence Syngeneic and xenograft tumor models, Smad and ERK inhibitors, IL-17RB knockdown, invasion/migration assays, clinical samples

    PMID:28715683 PMID:28993429

    Open questions at the time
    • Whether IL-17RA is required for IL-17B signaling in these cancer contexts was not always addressed
    • Therapeutic targeting of IL-17RB in tumors not validated
  11. 2019 High

    Genetic lineage tracing and cell ablation showed IL-17RB marks intestinal tumor stem cells and human colorectal cancer stem cells; ablation of IL-17RB+ cells strongly suppressed tumor growth, establishing IL-17RB as a functional cancer stem cell marker.

    Evidence Il17rb-CreERT2 lineage-tracing mice, CRISPR knockin organoids, xenograft tumor growth with in vivo ablation

    PMID:31182574

    Open questions at the time
    • Whether IL-17RB signaling is required for stemness or is merely a marker is not fully dissected
    • Upstream signals maintaining IL-17RB in CSCs beyond IL-13 are unknown
  12. 2019 Medium

    IL-17B was confirmed to signal through the IL-17RA/IL-17RB heteromeric complex (not IL-17RB alone) in human innate type 2 lymphocytes, NKT cells, and Th2 cells, resolving a longstanding question about whether IL-17B shares the same receptor architecture as IL-25.

    Evidence Receptor-blocking antibodies against IL-17RA and IL-17RB on primary human lymphocytes, cytokine ELISA

    PMID:30770417

    Open questions at the time
    • Whether IL-17B and IL-25 compete for binding or engage distinct sites on the complex is unknown
    • Structural basis for dual ligand recognition not determined
  13. 2025 Medium

    IL-17RB was found to be expressed in cortical neurons and, together with IL-17RA, to mediate IL-17E-dependent enhancement of social behavior, extending the receptor's functional role beyond immunity into the central nervous system.

    Evidence Brain-wide receptor expression mapping, genetic manipulation, and social interaction behavioral assays in mice

    PMID:40199322

    Open questions at the time
    • Downstream signaling pathway in neurons not characterized
    • Whether neuronal IL-17RB signals through the same pathways as in immune cells is unknown
    • Single study

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of the IL-17RA/IL-17RB heteromeric complex, how dual ligands (IL-25 and IL-17B) are discriminated, the intracellular signaling adaptors that connect the receptor to NF-κB/ERK/PI3K cascades, and whether IL-17RB signaling in cancer stem cells is a driver of stemness or a bystander marker.
  • No crystal structure of IL-17RA/IL-17RB complex
  • Intracellular adaptor recruitment mechanism undefined
  • Cancer stem cell role could be correlative

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 3
Localization
GO:0005886 plasma membrane 5 GO:0005576 extracellular region 1
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-168256 Immune System 5 R-HSA-1643685 Disease 4
Partners
IL17BIL17RAIL25
Complex memberships
IL-17RA/IL-17RB heteromeric receptor complex

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 IL-17RB (IL-17Rh1/EVI27) was identified as a receptor for the cytokine IL-17E (IL-25), and this interaction induces NF-κB activation and IL-8 production. Ligand-receptor binding assay, NF-κB reporter assay, IL-8 ELISA The Journal of biological chemistry High 11058597
2000 IL-17RB (EVI27) encodes a novel transmembrane protein with homology to the IL-17 receptor; multiple isoforms exist including secreted soluble forms produced by intron incorporation or proteolytic cleavage, and it is expressed on selected T-cell, B-cell and myeloid cell lines. Molecular cloning, Northern blot, Western blot, isoform characterization Oncogene Medium 10815801
2008 IL-25-mediated biological activities (including IL-5/IL-13 production and pulmonary inflammation) require both IL-17RB and IL-17RA as a heteromeric receptor complex; neither subunit alone is sufficient. Knockout mice (IL-17RB KO and IL-17RA KO), antagonistic monoclonal antibodies, in vitro splenocyte cytokine assay, in vivo intranasal IL-25 model Journal of immunology High 18768888
2009 IL-17RB is highly expressed on a subset of CD4+ invariant NKT (iNKT) cells but not on activated conventional T cells; IL-17RB+ iNKT cells produce large amounts of Th2 cytokines upon IL-25 stimulation and are necessary and sufficient to restore airway hyperreactivity (AHR) in iNKT-deficient mice. Flow cytometry, adoptive transfer into iNKT-deficient mice, intranasal IL-25 AHR model, cytokine assays Journal of immunology High 19342692
2009 IL-17RB (IL-25R) is expressed on IL-4-producing CD11b+GR1+ myeloid cells in the lung and bone marrow during chronic allergen challenge; SCF-stimulated c-kit+ eosinophils produce IL-25, and Th2 cytokine production from IL-17RB+ myeloid cells is dependent on SCF. Cell sorting, 4get reporter mice, flow cytometry, anti-SCF neutralization, cytokine measurement Journal of immunology Medium 19828636
2010 IL-17RB is expressed on basophils; IL-3 upregulates IL-17RB mRNA and protein on basophils; IL-25 activation of IL-17RB inhibits basophil apoptosis and enhances IgE-mediated degranulation. Flow cytometry, qRT-PCR, apoptosis assay (Annexin-V), beta-hexosaminidase degranulation assay, ELISA Clinical and experimental allergy Medium 20545698
2012 IL-25 promotes basic fibroblast growth factor (bFGF) expression and angiogenesis in human endothelial cells through IL-17RB but not IL-17RA, via a PI3K-dependent signaling pathway. Receptor-blocking antibodies, siRNA knockdown, PI3K inhibitor (LY294002), ELISA, in vitro angiogenesis assay, PCR Clinical and experimental allergy Medium 23106660
2013 COX-2-derived prostaglandins PGD2 and PGE2 suppress Th9 cell differentiation by downregulating IL-17RB expression via a protein kinase A-dependent mechanism. COX-2 KO mice, synthetic prostaglandins, selective inhibitors, siRNA, flow cytometry, real-time PCR, immunoblotting American journal of respiratory and critical care medicine Medium 23449692
2014 IL-17RB is aberrantly overexpressed in HTLV-1 immortalized T cells; Tax induces IL-17RB expression in an IKK/NF-κB-dependent manner; IL-17RB is required for Tax-induced canonical NF-κB activation, HTLV-1-induced immortalization of primary T cells, and survival of HTLV-1 transformed cells via an IL-9-dependent autocrine loop. RNA sequencing, siRNA knockdown, NF-κB reporter assay, T-cell immortalization assay, cytokine measurement, ATL patient sample analysis PLoS pathogens High 25340344
2014 IL-25 (IL-17E) and IL-17RB promote immunopathology during RSV infection; IL-17RB-/- mice show decreased Th2 and increased Th17 cytokine production along with reduced lung inflammation during RSV infection and RSV-driven asthma exacerbation. IL-17RB knockout mice, RSV infection model, neutralizing antibodies, cytokine measurement, AHR assay Journal of leukocyte biology Medium 24407884
2017 TGF-β1 secreted by Tregs in tumor-draining lymph nodes upregulates IL-17RB in breast tumor cells via Smad2/3/4 signaling, and IL-17RB upregulation contributes to increased tumor malignancy and distant metastasis. Syngeneic mouse mammary tumor model, TGF-β1 neutralization, Treg depletion, Smad pathway inhibition, xenograft tumor assay, clinical sample analysis EMBO molecular medicine Medium 28993429
2017 IL-17B activates IL-17RB in thyroid cancer cells to promote invasion and metastasis via ERK1/2 pathway-mediated MMP-9 upregulation; knockdown of IL-17RB attenuates IL-17B-induced invasion, and ERK1/2 inhibition blocks MMP-9 expression and invasion. IL-17RB knockdown, in vitro invasion/migration assays, in vivo xenograft, Western blot, ERK1/2 inhibitor Molecular immunology Medium 28715683
2019 IL-17RB marks intestinal tumor stem cells (TSCs) in mouse intestinal adenomas in an IL-13-dependent manner, and marks cancer stem cells (CSCs) in a subset of human colorectal cancers (hCRCs) that expand independently of IL-13; long-term ablation of IL-17RB-expressing CSCs strongly suppresses tumor growth in vivo. Il17rb-CreERT2 lineage-tracing mice, CRISPR-Cas9 IL17RB-CreERT2 knockin organoids, xenograft tumors, in vivo cell ablation Proceedings of the National Academy of Sciences of the United States of America High 31182574
2019 IL-17B signals through a heteromeric receptor complex composed of IL-17RA and IL-17RB (not IL-17RB alone) to induce type 2 cytokine secretion from innate type 2 lymphocytes, NKT cells, and CD4+CRTH2+ Th2 cells in humans; IL-17B can augment IL-33-driven type 2 responses. Primary human lymphocyte cultures, receptor-blocking antibodies, cytokine ELISA, flow cytometry Journal of immunology Medium 30770417
2025 IL-17RB is expressed in the cortex and, together with IL-17RA, mediates the enhancing effect of neuronal IL-17E on social interaction; IL-17E expressed in cortical neurons acts on IL-17RA- and IL-17RB-expressing neurons to enhance social behavior. Brain-wide receptor expression mapping, genetic manipulation, behavioral assays (social interaction) Cell Medium 40199322
2017 IL17RB/IL17B signaling in breast cancer cells activates NF-κB and upregulates Bcl-2; simultaneous IL17RB siRNA knockdown and doxorubicin treatment induces apoptosis and inhibits migration. siRNA knockdown, NF-κB and Bcl-2 gene expression assay, Annexin-V apoptosis assay, wound healing migration assay Biomedicine & pharmacotherapy Low 27372407
2017 IL17RB promotes liver regeneration by enhancing the growth of small hepatocyte-like progenitor cells (SHPCs); Thy1+ cell-derived extracellular vesicles induce IL17RB expression in SHPCs, and IL17B stimulates the proliferation of small hepatocytes via IL17RB signaling. GeneChip analysis, cell transplantation model, extracellular vesicle treatment, in vitro growth assay Stem cells Low 27925343

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.). British journal of haematology 522 24328678
2016 Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase. Nature 471 26909574
2001 IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. The Journal of biological chemistry 312 11058597
2008 Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. Journal of immunology (Baltimore, Md. : 1950) 277 18768888
2010 Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell 273 20178741
2014 Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus. Cancer cell 204 25026211
2010 Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. Molecular cell 202 21035370
2011 Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase. Genes & development 193 21828267
2015 Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4. Blood cancer journal 188 26430725
2010 CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Molecular cell 188 20932472
2013 Prediction of late disease recurrence and extended adjuvant letrozole benefit by the HOXB13/IL17BR biomarker. Journal of the National Cancer Institute 167 23812955
2017 pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase. Nature communications 141 28530236
2010 CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis. Molecular cell 138 20129063
2021 CRL4AMBRA1 is a master regulator of D-type cyclins. Nature 131 33854235
2011 Control of Drosophila endocycles by E2F and CRL4(CDT2). Nature 129 22037307
2018 Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity. Blood 106 30042095
2013 CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science (New York, N.Y.) 102 24357321
2011 SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. The Journal of cell biology 101 21220508
2007 HOXB13-to-IL17BR expression ratio is related with tumor aggressiveness and response to tamoxifen of recurrent breast cancer: a retrospective study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 99 17308270
2019 Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15. Cell reports 92 31693891
2014 CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases. Molecular cell 88 25557551
2009 Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. Journal of immunology (Baltimore, Md. : 1950) 84 19342692
2022 Targeting CRL4 suppresses chemoresistant ovarian cancer growth by inducing mitophagy. Signal transduction and targeted therapy 83 36481655
2018 Vpr Targets TET2 for Degradation by CRL4VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication. Molecular cell 81 29883611
2020 ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells. Nature chemical biology 75 32958952
2013 Ubiquitin E3 ligase CRL4(CDT2/DCAF2) as a potential chemotherapeutic target for ovarian surface epithelial cancer. The Journal of biological chemistry 75 23995842
2013 Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase. Molecular cell 70 23478441
2013 The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells. Nucleic acids research 69 23677613
2009 Pulmonary IL-17E (IL-25) production and IL-17RB+ myeloid cell-derived Th2 cytokine production are dependent upon stem cell factor-induced responses during chronic allergic pulmonary disease. Journal of immunology (Baltimore, Md. : 1950) 67 19828636
2015 CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation. Nature communications 66 26281983
2012 Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease. Frontiers in oncology 64 22649780
2016 Co-delivery of IL17RB siRNA and doxorubicin by chitosan-based nanoparticles for enhanced anticancer efficacy in breast cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 62 27372407
2020 PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network. Molecular cell 61 31973889
2016 Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma. EBioMedicine 60 27333051
2012 CRL4(CDT2) targets CHK1 for PCNA-independent destruction. Molecular and cellular biology 58 23109433
2017 The role of IL17B-IL17RB signaling pathway in breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 57 28160754
2017 Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1. Journal of medicinal chemistry 57 28358507
2010 Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 56 20545698
2019 Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America 54 31182574
2018 Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase. Nature communications 52 29691401
2000 Evi27 encodes a novel membrane protein with homology to the IL17 receptor. Oncogene 50 10815801
2013 A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase. The Journal of biological chemistry 49 23913683
2017 TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB. EMBO molecular medicine 48 28993429
2011 Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best! FEBS letters 48 21550341
2014 Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death. Proceedings of the National Academy of Sciences of the United States of America 47 25349427
2007 Exploring the two-gene ratio in breast cancer--independent roles for HOXB13 and IL17BR in prediction of clinical outcome. Breast cancer research and treatment 47 17453342
2022 MYB43 as a novel substrate for CRL4PRL1 E3 ligases negatively regulates cadmium tolerance through transcriptional inhibition of HMAs in Arabidopsis. The New phytologist 46 35129221
2021 USP15 antagonizes CRL4CRBN-mediated ubiquitylation of glutamine synthetase and neosubstrates. Proceedings of the National Academy of Sciences of the United States of America 42 34583995
2019 The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation. Cellular and molecular life sciences : CMLS 42 31492966
2015 The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications. Oncotarget 42 26460955
2023 Glucose-induced CRL4COP1-p53 axis amplifies glycometabolism to drive tumorigenesis. Molecular cell 41 37390815
2012 CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10. Nucleic acids research 41 22570418
2024 Transcription-coupled DNA-protein crosslink repair by CSB and CRL4CSA-mediated degradation. Nature cell biology 40 38600236
2020 CRL4DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development. Science advances 39 33355139
2018 CRL4DCAF2 negatively regulates IL-23 production in dendritic cells and limits the development of psoriasis. The Journal of experimental medicine 39 30018073
2018 Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase. The Journal of biological chemistry 39 30442713
2008 Association of IL-17RB gene polymorphism with asthma. Chest 39 19118269
2019 Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability. EMBO reports 38 31267705
2013 VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases. BMC molecular biology 38 24028781
2013 Cyclooxygenase-2 inhibits T helper cell type 9 differentiation during allergic lung inflammation via down-regulation of IL-17RB. American journal of respiratory and critical care medicine 37 23449692
2016 Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. Molecular cell 36 27203177
2019 Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer. The Journal of pathology 35 30945288
2016 CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. Nature communications 35 27098497
2014 IL-17E (IL-25) and IL-17RB promote respiratory syncytial virus-induced pulmonary disease. Journal of leukocyte biology 35 24407884
2011 The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1. Biochemistry 34 21226479
2014 A critical role for IL-17RB signaling in HTLV-1 tax-induced NF-κB activation and T-cell transformation. PLoS pathogens 33 25340344
2020 CRL4Cdt2: Coupling Genome Stability to Ubiquitination. Trends in cell biology 32 32044173
2012 Interleukin-25 promotes basic fibroblast growth factor expression by human endothelial cells through interaction with IL-17RB, but not IL-17RA. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 32 23106660
2010 Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4(Cdt2) -mediated proteolysis. Genes to cells : devoted to molecular & cellular mechanisms 32 21143559
2020 The RepID-CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation. Nature communications 31 31911655
2017 IL-17RB enhances thyroid cancer cell invasion and metastasis via ERK1/2 pathway-mediated MMP-9 expression. Molecular immunology 31 28715683
2017 CRL4DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver. Cell reports 30 28178526
2013 HOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease. Breast cancer research : BCR 29 23497539
2023 Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex. Nature communications 28 37353483
2021 IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion. Nature communications 28 33911083
2020 CRL4DCAF8 dependent opposing stability control over the chromatin remodeler LSH orchestrates epigenetic dynamics in ferroptosis. Cell death and differentiation 28 33288900
2025 Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB. Cell 27 40199322
2022 Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences of the United States of America 27 35105802
2018 CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory. PLoS genetics 27 29370161
2020 The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer. International journal of biological sciences 26 32140074
2019 Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes. Journal of immunology (Baltimore, Md. : 1950) 26 30770417
2016 CRL4(WDR23)-Mediated SLBP Ubiquitylation Ensures Histone Supply during DNA Replication. Molecular cell 26 27203182
2017 Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly. Journal of virology 25 28202763
2011 The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex. BMC pulmonary medicine 25 21473777
2015 CRL4(RBBP7) is required for efficient CENP-A deposition at centromeres. Journal of cell science 24 25795299
2022 CRL4CRBN E3 Ligase Complex as a Therapeutic Target in Multiple Myeloma. Cancers 23 36139651
2019 Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism. Current biology : CB 23 31155351
2017 HIV-1 Vpr protein directly loads helicase-like transcription factor (HLTF) onto the CRL4-DCAF1 E3 ubiquitin ligase. The Journal of biological chemistry 23 29079575
2014 CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing. Proceedings of the National Academy of Sciences of the United States of America 23 24449894
2022 Hypoxia-inducible CircPFKFB4 Promotes Breast Cancer Progression by Facilitating the CRL4DDB2 E3 Ubiquitin Ligase-mediated p27 Degradation. International journal of biological sciences 22 35813480
2021 CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation. International journal of molecular sciences 21 34065512
2011 Upregulation of IL17RB during natural allergen exposure in patients with seasonal allergic rhinitis. Allergology international : official journal of the Japanese Society of Allergology 21 21252617
2017 Transplantation of Thy1+ Cells Accelerates Liver Regeneration by Enhancing the Growth of Small Hepatocyte-Like Progenitor Cells via IL17RB Signaling. Stem cells (Dayton, Ohio) 20 27925343
2014 C/EBPα regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint. Cell cycle (Georgetown, Tex.) 20 25483090
2020 Inflammation and DNA Methylation-Dependent Down-Regulation of miR-34b-5p Mediates c-MYC Expression and CRL4DCAF4 E3 Ligase Activity in Colitis-Associated Cancer. The American journal of pathology 19 31972160
2019 Characteristic Pattern of IL-17RA, IL-17RB, and IL-17RC in Monocytes/Macrophages and Mast Cells From Patients With Bullous Pemphigoid. Frontiers in immunology 19 31572359
2023 Recognition of the CCT5 di-Glu degron by CRL4DCAF12 is dependent on TRiC assembly. The EMBO journal 18 36715408
2023 A Degron Blocking Strategy Towards Improved CRL4CRBN Recruiting PROTAC Selectivity. Chembiochem : a European journal of chemical biology 18 37418539
2017 SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. The FEBS journal 18 28886238
2013 Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2. Cell cycle (Georgetown, Tex.) 18 23892434