Affinage

IL17B

Interleukin-17B · UniProt Q9UHF5

Length
180 aa
Mass
20.4 kDa
Annotated
2026-04-28
100 papers in source corpus 14 papers cited in narrative 14 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IL-17B is a secreted cytokine of the IL-17 family that signals through a receptor complex containing IL-17RB (and IL-17RA as co-receptor on immune cells) to activate ERK1/2, NF-κB, STAT3, Akt, p38 MAPK, and β-catenin pathways, driving pro-inflammatory cytokine and chemokine production in monocytes, epithelial cells, and mesenchymal stromal cells (PMID:10639155, PMID:28039016, PMID:28145881, PMID:30770417). In the immune system, IL-17B stimulates TNF-α and IL-1β release from monocytes, elicits type 2 cytokine secretion from innate lymphoid cells, NKT cells, and Th2 cells, and exacerbates inflammatory arthritis in vivo (PMID:10639155, PMID:17982105, PMID:30770417). In cancer, IL-17B–IL-17RB signaling promotes tumor invasion, chemoresistance via ERK-dependent upregulation of BCL-2 family proteins, and cancer stem cell self-renewal through TRAF6-mediated K63 ubiquitination of Beclin-1 and consequent autophagy activation (PMID:25732306, PMID:29371916, PMID:33649532). In the peripheral nervous system, Schwann cell–derived IL-17B acts in an autocrine manner to recruit macrophages to injured nerves, facilitating myelin clearance and axon regeneration (PMID:38341853).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2000 High

    Cloning of IL-17B established it as a distinct IL-17 family member that stimulates monocyte TNF-α/IL-1β production yet does not bind the canonical IL-17R, implying a separate receptor and a non-redundant pro-inflammatory function.

    Evidence Recombinant protein expression, FACS binding assay, and cytokine induction in THP-1 monocytic cells

    PMID:10639155

    Open questions at the time
    • Cognate receptor not yet identified
    • No in vivo functional data
    • Downstream signaling pathway undefined
  2. 2002 High

    Expression mapping revealed IL-17B is prominently produced by neurons in the CNS and peripheral ganglia, expanding its potential functional scope beyond classical immune tissues.

    Evidence Northern blot, in situ hybridization, and immunohistochemistry in human and mouse neural tissues

    PMID:11738356

    Open questions at the time
    • Neuronal function of IL-17B not tested
    • Receptor expression pattern in nervous system not characterized
  3. 2007 High

    In vivo studies demonstrated that IL-17B is a bona fide pro-inflammatory cytokine capable of exacerbating autoimmune arthritis, and that neutralizing IL-17B suppresses joint destruction, establishing disease relevance.

    Evidence Adoptive transfer of IL-17B-transduced CD4+ T cells and anti-IL-17B neutralizing antibody in the collagen-induced arthritis mouse model

    PMID:17982105

    Open questions at the time
    • Direct receptor identity still unknown
    • Mechanism of action in joint tissue not elucidated
  4. 2015 High

    Identification of IL-17RB as the signaling receptor and ERK1/2 as the key downstream pathway resolved how IL-17B promotes cancer cell invasion and metastasis via chemokine induction (CCL20, CXCL1, IL-8).

    Evidence IL-17B/IL-17RB overexpression, ERK pathway analysis, anti-IL-17RB antibody blockade in pancreatic cancer xenograft model

    PMID:25732306

    Open questions at the time
    • IL-17RA involvement as co-receptor not yet established
    • Structural basis of IL-17B–IL-17RB interaction unknown
  5. 2016 Medium

    IL-17B was shown to activate Akt, p38 MAPK, ERK, and NF-κB in bronchial epithelial cells to induce IL-8, broadening the pathway repertoire beyond ERK alone and demonstrating cell-type-specific responsiveness.

    Evidence Recombinant IL-17B treatment with pathway inhibitors and signaling readouts in human bronchial epithelial cells vs. fibroblasts

    PMID:28039016

    Open questions at the time
    • Single-lab finding without independent replication
    • Receptor complex composition on epithelial cells not defined
  6. 2017 High

    Two studies established that IL-17B–ERK signaling drives chemoresistance in breast cancer (via BCL-2 upregulation) and activates NF-κB/STAT3/β-catenin stemness programs in mesenchymal stromal cells, revealing roles in therapy resistance and tumor microenvironment remodeling.

    Evidence ERK inhibitor and anti-IL-17RB antibody rescue of paclitaxel resistance in vivo; recombinant IL-17B treatment of MSCs with pathway and conditioned-medium assays

    PMID:28145881 PMID:29371916

    Open questions at the time
    • Relative contribution of each pathway branch to chemoresistance not dissected
    • In vivo MSC–tumor interaction not validated with genetic models
  7. 2019 High

    Definition of IL-17RA–IL-17RB as the heterodimeric receptor complex on immune cells and demonstration that IL-17B elicits type 2 cytokine responses from ILC2s, NKT, and Th2 cells resolved how IL-17B engages adaptive and innate immunity.

    Evidence Blocking antibodies against IL-17RA and IL-17RB subunits, cytokine secretion assays from multiple human lymphocyte subsets

    PMID:30770417

    Open questions at the time
    • Signaling adaptors downstream of IL-17RA/RB in lymphocytes not identified
    • Physiological contexts triggering IL-17B release in immunity unclear
  8. 2021 High

    Mechanistic dissection showed IL-17B promotes gastric cancer stem cell self-renewal through TRAF6-mediated K63-linked ubiquitination of Beclin-1 and autophagy activation, linking IL-17B signaling to the autophagy machinery for the first time.

    Evidence Co-immunoprecipitation, ubiquitination assay, ATG7 siRNA knockdown, sphere formation, and xenograft validation

    PMID:33649532

    Open questions at the time
    • Whether TRAF6-Beclin-1 axis operates in non-cancer contexts unknown
    • Direct recruitment mechanism of TRAF6 to IL-17RB not defined
  9. 2021 Medium

    Tumor-derived IL-17B carried in extracellular vesicles was shown to reprogram pancreatic stellate cell metabolism toward oxidative phosphorylation, revealing a paracrine metabolic coupling between tumor and stroma through EV-mediated IL-17B delivery.

    Evidence EV isolation, IL-17RB modulation in stellate cells, metabolic flux analysis, co-injection xenograft

    PMID:34771503

    Open questions at the time
    • EV-loading mechanism for IL-17B not characterized
    • In vivo metabolic reprogramming not confirmed by isotope tracing
  10. 2024 High

    Conditional knockout studies established that Schwann cell–derived IL-17B acts in an autocrine loop through IL-17RB to recruit macrophages after peripheral nerve injury, linking IL-17B to nerve repair and myelin clearance.

    Evidence Global and Schwann-cell-specific IL-17B knockout mice, peripheral nerve crush model with macrophage infiltration and axon regeneration quantification

    PMID:38341853

    Open questions at the time
    • Downstream chemokines mediating macrophage recruitment by Schwann cells not fully defined
    • Whether IL-17B plays analogous roles in CNS demyelination untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • No structural model of the IL-17B–IL-17RB–IL-17RA ternary complex exists, and the proximal signaling adaptors linking the receptor to TRAF6, ERK, and NF-κB remain incompletely mapped; a unified model integrating IL-17B's immunological, neural, and oncogenic functions is lacking.
  • No crystal or cryo-EM structure of IL-17B or its receptor complex
  • Adaptor molecules connecting IL-17RB to TRAF6 and MAPK cascades not identified
  • Physiological triggers controlling IL-17B secretion in non-cancer settings unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 4
Localization
GO:0005576 extracellular region 4
Pathway
R-HSA-162582 Signal Transduction 6 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 3 R-HSA-9612973 Autophagy 1
Partners
BECN1IL17RAIL17RBTRAF6

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 IL-17B was cloned and found to stimulate TNF-alpha and IL-1beta release from the monocytic cell line THP-1, while failing to bind the IL-17 receptor extracellular domain or induce IL-6 from fibroblasts, establishing it as a distinct IL-17 family member with a separate receptor. Recombinant protein expression, FACS binding assay, cytokine induction assay in THP-1 cells Proceedings of the National Academy of Sciences of the United States of America High 10639155
2002 IL-17B mRNA and protein are primarily expressed by neurons in spinal cord, dorsal root ganglia, and brain (neuronal cell bodies and axons), as determined by Northern analysis, in situ hybridization, and immunohistochemistry. Northern blot, in situ hybridization, immunohistochemistry Neuromuscular disorders : NMD High 11738356
2007 IL-17B and IL-17C stimulate TNF-alpha production from mouse peritoneal exudate cells in vitro, and adoptive transfer of IL-17B-transduced CD4+ T cells exacerbates collagen-induced arthritis in vivo; neutralization of IL-17B significantly suppressed arthritis progression and bone destruction. In vitro cytokine induction assay, adoptive T cell transfer, bone marrow chimeric mice, anti-IL-17B neutralizing antibody treatment in CIA model Journal of immunology (Baltimore, Md. : 1950) High 17982105
2007 IL-17B and IL-17C are expressed in cartilage and chondrocytes during fracture healing and in the epiphyseal growth plate, with localization paralleling that of IL-17R and IL-17RL, suggesting a role in endochondral differentiation. Immunolocalization (immunohistochemistry) in fracture callus and growth plate The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society Low 17827167
2015 IL-17B–IL-17RB signaling activates the ERK1/2 pathway to upregulate CCL20, CXCL1, IL-8, and TFF1 chemokines, promoting pancreatic cancer cell invasion, macrophage and endothelial cell recruitment, and cancer cell survival at distant sites; anti-IL-17RB antibody blocked tumor metastasis in a xenograft model. Ex vivo experiments with IL-17B/IL-17RB overexpression, ERK1/2 pathway analysis, xenograft mouse model, monoclonal antibody blockade The Journal of experimental medicine High 25732306
2017 IL-17B induces resistance to paclitaxel in breast tumors through activation of the ERK1/2 pathway, leading to upregulation of anti-apoptotic BCL-2 family proteins; pharmacological blockade of ERK (PD98059) or anti-IL-17RB antibody abolished this chemoresistance in vivo. In vitro ERK1/2 signaling analysis, in vivo paclitaxel resistance model, anti-IL-17RB neutralizing antibody, MEK inhibitor PD98059 Oncotarget High 29371916
2017 IL-17B activates NF-κB, STAT3, and β-catenin pathways in mesenchymal stem cells, inducing stemness-related genes (Nanog, Sox2, Oct4) and causing MSCs to secrete soluble factors that promote gastric cancer cell proliferation and migration. Recombinant IL-17B treatment of MSCs, Western blot for pathway activation, conditioned medium experiments, proliferation and migration assays Oncotarget Medium 28145881
2018 IL-17RB overexpression in lung cancer cells induces ERK phosphorylation, GSK3β inactivation, and β-catenin upregulation; IL-17RB also participates in IL-17B synthesis via ERK, forming a positive feedback loop that enhances invasion and metastasis. IL-17RB overexpression, in vitro invasion/migration assays, ERK/GSK3β/β-catenin pathway analysis, in vivo metastasis model Cancer letters Medium 29496538
2019 IL-17B signals through a receptor complex composed of IL-17RA and IL-17RB to elicit type 2 cytokine secretion from innate type 2 lymphocytes, NKT, and CD4+ CRTH2+ Th2 cells in the human immune system, and can augment IL-33-driven type 2 responses. Receptor subunit requirement experiments with blocking antibodies, cytokine secretion assays from human lymphocyte subsets Journal of immunology (Baltimore, Md. : 1950) High 30770417
2021 IL-17B/IL-17RB signaling promotes self-renewal and tumorigenesis of gastric cancer stem cells by inducing TRAF6-mediated K63-linked ubiquitination of Beclin-1, thereby activating autophagy; ATG7 knockdown reversed IL-17B-induced CSC self-renewal. Sphere-formation assay, xenograft mouse model, co-immunoprecipitation of TRAF6-Beclin-1, ubiquitination assay, ATG7 siRNA knockdown, LC3 autophagy markers Oncogene High 33649532
2021 Tumor-derived IL-17B carried in extracellular vesicles activates pancreatic stellate cells (PSCs) and induces IL-17RB expression in PSCs; IL-17B/IL-17RB signaling increases oxidative phosphorylation and reduces mitochondrial turnover in PSCs, which then activate tumor cells via a feedback loop involving IL-6, increasing tumor oxidative phosphorylation and decreasing glycolysis. Extracellular vesicle isolation, IL-17RB overexpression in PSCs, co-injection xenograft model, metabolic flux analysis Cancers Medium 34771503
2024 Schwann-cell-secreted IL-17B acts in an autocrine manner by binding to IL-17RB on Schwann cells to promote macrophage recruitment to injured peripheral nerves; global or Schwann-cell-specific IL-17B deletion reduces macrophage infiltration, myelin clearance, and axon regeneration after peripheral nerve injury. Mlkl-/- and Sarm1-/- mouse models, global and conditional (Schwann-cell-specific) IL-17B knockout mice, peripheral nerve injury model, macrophage infiltration and myelin clearance quantification Cell reports High 38341853
2016 IL-17B induces IL-8 gene and protein expression in human bronchial epithelial cells (but not lung fibroblasts) through activation of Akt, p38 MAPK, ERK, and NF-κB signaling pathways. Recombinant IL-17B treatment, RT-PCR, ELISA, Western blot for signaling pathway components in bronchial epithelial cells Clinical immunology (Orlando, Fla.) Medium 28039016
2010 Recombinant human IL-17B inhibits endothelial cell-matrix adhesion and migration, and at higher concentrations substantially reduces tubule formation in a Matrigel assay, suggesting an anti-angiogenic function. In vitro cell adhesion assay, migration assay, Matrigel tubule formation assay with HECV endothelial cells Journal of oncology Low 20467469

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. Journal of immunology (Baltimore, Md. : 1950) 422 17277128
2009 IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not. Journal of molecular medicine (Berlin, Germany) 352 19330474
2001 Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. Journal of immunology (Baltimore, Md. : 1950) 339 11564763
2014 The IL-20 subfamily of cytokines--from host defence to tissue homeostasis. Nature reviews. Immunology 311 25421700
2000 Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. Proceedings of the National Academy of Sciences of the United States of America 276 10639155
2008 The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29. The Journal of allergy and clinical immunology 256 18405958
2006 Interleukin (IL)-19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs. Experimental dermatology 204 17083366
2007 IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis. Journal of immunology (Baltimore, Md. : 1950) 163 17982105
2004 Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. Journal of immunology (Baltimore, Md. : 1950) 145 14764663
2009 The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. European journal of immunology 144 19830738
2015 Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. The Journal of experimental medicine 139 25732306
2008 Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes. Journal of leukocyte biology 131 18281438
2006 Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26. European journal of immunology 123 16365913
2013 Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus. Nature immunology 106 23793061
2007 IL-19 and IL-20: two novel cytokines with importance in inflammatory diseases. Expert opinion on therapeutic targets 98 17465720
2004 Bystander activity of Ad-mda7: human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism. Molecular therapy : the journal of the American Society of Gene Therapy 93 15564140
2007 The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy. Cytokine 92 18061474
2005 Detection of IL-20 and its receptors on psoriatic skin. Clinical immunology (Orlando, Fla.) 91 16043414
2009 IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression. European journal of immunology 85 19731362
2006 Prominent production of IL-20 by CD68+/CD11c+ myeloid-derived cells in psoriasis: Gene regulation and cellular effects. The Journal of investigative dermatology 84 16645593
2006 IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Arteriosclerosis, thrombosis, and vascular biology 78 16778121
2010 IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis. Journal of immunology (Baltimore, Md. : 1950) 76 20061404
2017 IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice. PloS one 73 28125663
2003 IL-10 subfamily members: IL-19, IL-20, IL-22, IL-24 and IL-26. Immunology letters 72 12941475
2011 Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. The Journal of experimental medicine 71 21844205
2006 IL-20: biological functions and clinical implications. Journal of biomedical science 69 16703417
2017 IL-17B: A new area of study in the IL-17 family. Molecular immunology 68 28704706
2014 IL-20 and IL-20R1 antibodies protect against liver fibrosis. Hepatology (Baltimore, Md.) 65 24763901
2012 Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models. Journal of immunology (Baltimore, Md. : 1950) 65 22238453
2020 The Emerging Role of the IL-17B/IL-17RB Pathway in Cancer. Frontiers in immunology 63 32373132
2009 IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke. Journal of immunology (Baltimore, Md. : 1950) 63 19342680
2018 IL-20 receptor cytokines in autoimmune diseases. Journal of leukocyte biology 62 30260500
2005 mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer. Molecular therapy : the journal of the American Society of Gene Therapy 60 15851011
2020 IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models. Nature communications 59 32929072
2018 The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis. Frontiers in immunology 57 30319661
2017 The role of IL17B-IL17RB signaling pathway in breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 57 28160754
2007 IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs. Proceedings of the National Academy of Sciences of the United States of America 55 17878297
2006 Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10. Cancer immunology, immunotherapy : CII 55 16710719
2010 IL-20: biological functions mediated through two types of receptor complexes. Cytokine & growth factor reviews 54 20864382
2005 Possible relations between the polymorphisms of the cytokines IL-19, IL-20 and IL-24 and plaque-type psoriasis. Genes and immunity 53 15889129
2011 Research in practice: IL-22 and IL-20: significance for epithelial homeostasis and psoriasis pathogenesis. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 52 21251229
2009 IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses. Journal of immunology (Baltimore, Md. : 1950) 52 19124723
2012 Identification of pro-inflammatory cytokines associated with muscle invasive bladder cancer; the roles of IL-5, IL-20, and IL-28A. PloS one 51 22962576
2012 IL-10-- and IL-20--expressing epithelial and inflammatory cells are increased in patients with ulcerative colitis. Journal of clinical immunology 50 23207823
2010 IL-19, IL-20 and IL-24: potential therapeutic targets for autoimmune diseases. Expert opinion on therapeutic targets 50 21073280
2007 Immunolocalization of IL-17A, IL-17B, and their receptors in chondrocytes during fracture healing. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 45 17827167
2008 IL-20 may contribute to the pathogenesis of human intervertebral disc herniation. Spine 42 18758357
2002 Expression of IL-17B in neurons and evaluation of its possible role in the chromosome 5q-linked form of Charcot-Marie-Tooth disease. Neuromuscular disorders : NMD 42 11738356
2018 IL-19 and Other IL-20 Family Member Cytokines in Vascular Inflammatory Diseases. Frontiers in immunology 41 29681905
2017 The IL-17B-IL-17 receptor B pathway promotes resistance to paclitaxel in breast tumors through activation of the ERK1/2 pathway. Oncotarget 41 29371916
2019 Interleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 Pathway. International journal of molecular sciences 40 31311100
2009 Cloning of a novel interleukin (IL)-20-like gene in rainbow trout Oncorhynchus mykiss gives an insight into the evolution of the IL-10 family. Developmental and comparative immunology 40 19755128
2003 Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20. Blood 38 12855566
2022 IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis. Gut 35 35613844
2018 A positive feedback loop of IL-17B-IL-17RB activates ERK/β-catenin to promote lung cancer metastasis. Cancer letters 35 29496538
2017 IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells. Oncotarget 35 28145881
2016 IL-20 promotes epithelial healing of the injured mouse cornea. Experimental eye research 35 27818315
2011 IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF. European journal of cancer (Oxford, England : 1990) 35 21565488
2005 IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression. Biochemical and biophysical research communications 35 15950941
2021 IL-17B/IL-17RB signaling cascade contributes to self-renewal and tumorigenesis of cancer stem cells by regulating Beclin-1 ubiquitination. Oncogene 34 33649532
2006 Leukocyte infiltration and mRNA expression of IL-20, IL-8 and TNF-R P60 in psoriatic skin is driven by TNF-alpha. International journal of immunopathology and pharmacology 34 16831294
2012 Anti-IL-20 monoclonal antibody alleviates inflammation in oral cancer and suppresses tumor growth. Molecular cancer research : MCR 32 23002091
2009 IL-20 activates human lymphatic endothelial cells causing cell signalling and tube formation. Microvascular research 31 19281830
2013 IL-20, IL-21 and p40: potential biomarkers of treatment response for ustekinumab. Acta dermato-venereologica 30 22930279
2012 Etanercept suppresses regenerative hyperplasia in psoriasis by acutely downregulating epidermal expression of interleukin (IL)-19, IL-20 and IL-24. The British journal of dermatology 30 22458549
2024 Schwann cell promotes macrophage recruitment through IL-17B/IL-17RB pathway in injured peripheral nerves. Cell reports 29 38341853
2020 IL-20 in Acute Kidney Injury: Role in Pathogenesis and Potential as a Therapeutic Target. International journal of molecular sciences 28 32028746
2016 Diabetic Wounds Exhibit Decreased Ym1 and Arginase Expression with Increased Expression of IL-17 and IL-20. Advances in wound care 27 27867753
2019 Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes. Journal of immunology (Baltimore, Md. : 1950) 26 30770417
2017 Increased interleukin (IL)-20 and IL-24 target osteoblasts and synovial monocytes in spondyloarthritis. Clinical and experimental immunology 26 28369789
2020 Anti-IL-20 antibody improved motor function and reduced glial scar formation after traumatic spinal cord injury in rats. Journal of neuroinflammation 25 32408881
2017 Anti-IL-20 monoclonal antibody inhibited inflammation and protected against cartilage destruction in murine models of osteoarthritis. PloS one 24 28426699
2006 The murine liver is a potential target organ for IL-19, IL-20 and IL-24: Type I Interferons and LPS regulate the expression of IL-20R2. Journal of hepatology 24 17069926
2024 IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling. Gut 23 37884352
2005 Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1. Tissue antigens 23 15713213
2018 The roles of IL-19 and IL-20 in the inflammation of degenerative lumbar spondylolisthesis. Journal of inflammation (London, England) 22 30250404
2016 A Broad Blockade of Signaling from the IL-20 Family of Cytokines Potently Attenuates Collagen-Induced Arthritis. Journal of immunology (Baltimore, Md. : 1950) 22 27619991
2016 Regulation of IL-20 Expression by Estradiol through KMT2B-Mediated Epigenetic Modification. PloS one 22 27806114
2021 IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation. Immunology 21 34403503
2012 Expression of IL-20 in synovium and lesional skin of patients with psoriatic arthritis: differential response to alefacept treatment. Arthritis research & therapy 21 23006144
2015 IL-20 in rheumatoid arthritis. Drug discovery today 20 26297177
2020 Effects of IL-1β, IL-20, and BMP-2 on Intervertebral Disc Inflammation under Hypoxia. Journal of clinical medicine 19 31947928
2017 IL-20 Signaling in Activated Human Neutrophils Inhibits Neutrophil Migration and Function. Journal of immunology (Baltimore, Md. : 1950) 19 28424238
2006 Human fetal membrane expression of IL-19 and IL-20 and its differential effect on inflammatory cytokine production. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 19 16854693
2015 Anti-IL-20 Monoclonal Antibody Suppresses Prostate Cancer Growth and Bone Osteolysis in Murine Models. PloS one 18 26440411
2003 IL-20: a new target for the treatment of inflammatory skin disease. Expert opinion on therapeutic targets 18 12667095
2004 Bacterial endotoxin induces IL-20 expression in the glial cells. Brain research. Molecular brain research 17 15519673
2019 IL-20-Receptor Signaling Delimits IL-17 Production in Psoriatic Inflammation. The Journal of investigative dermatology 16 31252033
2016 The Role of the IL-20 Subfamily in Glaucoma. Mediators of inflammation 16 26903709
2015 AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic Skin. The Journal of investigative dermatology 16 26176762
2022 IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 15 35486004
2021 Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation. Frontiers in cellular neuroscience 15 34557075
2020 IL-20 promotes hypoxia/reoxygenation-induced mitochondrial dysfunction and apoptosis in cardiomyocytes by upregulating oxidative stress by activating the PKC/NADPH oxidase pathway. Biochimica et biophysica acta. Molecular basis of disease 15 31953216
2016 IL-17B is elevated in patients with pneumonia and mediates IL-8 production in bronchial epithelial cells. Clinical immunology (Orlando, Fla.) 15 28039016
2010 IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis. Journal of oncology 15 20467469
2018 Modulation of Th1/Tc1 and Th17/Tc17 responses in pulmonary tuberculosis by IL-20 subfamily of cytokines. Cytokine 14 29684756
2012 Combination of IL-1 receptor antagonist, IL-20 and CD40 ligand for the prediction of acute cellular renal allograft rejection. Journal of clinical immunology 14 22948742
2021 IL-17B/RB Activation in Pancreatic Stellate Cells Promotes Pancreatic Cancer Metabolism and Growth. Cancers 13 34771503
2020 A single-center observational study on the expression of circulating interleukin-20 levels and predicting outcomes in human chronic heart failure: A 2-year follow-up cohort study: Higher IL-20 levels suggest poorer outcomes in CHF patients. Clinica chimica acta; international journal of clinical chemistry 13 32622964
2012 Genetic polymorphisms of interleukin 20 (IL-20) in patients with ulcerative colitis. Immunology letters 12 23183096